Electrical Stimulation in Restricted Area of Abdominal Skin Increased Glucose Level via the Pancreatic Branch of the Vagal Nerve in the Rat

Abstract

Electrical stimulation (5 V, 50 Hz, 10 min.) of the middle upper abdominal area (Chuin acupuncture point) increased the blood sugar level in rats anesthetized with chloralose (60 mg/kg) and urethane (0.6 g/kg). Stimulation of both sides of middle abdominal skin area also increased the blood sugar level. However, electrical stimulation of other areas of the abdominal skin or the front paw. lower leg or thigh did not alter blood sugar level. Electrical stimulation of the middle upper abdomen inhibited spontaneous firing of the vagal nerve that innervates the pancreas, and enhanced neuronal discharges elicited in those fibers by intravenous glucose injection.

Keywords

Acupuncture stimulation glucose level neural discharge vagal nerve rat

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References

Kaufman

Sato

. Reflex changes in heart rate after mechanical and thermal stimulation of skin at various segmental levels in cats. Neuroscience, Vol.2, 103–109, 1977.

Sato

Shimada

, Varying changes in heart rate produced by nociceptive stimulation of the skin in rats at different temperatures. Brain Res, Vol.110, 301–311, 1976.

Sato

and Schmidt

R.F.

Changes in blood pressure and heart rate 1 nduced by movements of normal and Inflamed knee Joints. Neuroscl. Lett., Vol.52, 55–66 1984.

Koizumi

Sato

and Terui

Role of somatic afferents in autonomic system control of the Intestinal motility. Brain Res, Vol.182, 85–97, 1980.

Yazawa

and Nishijo

The mechanism of autonomic nervous system in acupuncture-stimulated bradycardia. J. Jpn. Soc. Acununct., Vol.34, 201–206, 1985.

Takeshige

Mechanism of acupuncture analgesia based on animal experiments. In Pomeranz

and Stux G (Eds.) Scientific bases, of acupuncture. Springer-Verlag, Berlin, Heidelberg New York London Paris Tokyo, 53–78, 1989

Terasawa

Yamagwa

Yuasa

et. al., Acupuncture therapy for diabetes mellltus: (2) Change of serum insulin-concerning blood insulin and blood sugar value of diabetes patients through acupuncture. J. Jpn. Acupunct. Moxibustion. Snc., Vol.30, 147–152, 1981.

Hasegawa

Terasawa

and Yuasa

Acupuncture therapy for diabetes mellltus: (IV) Influence of several kinds of acupuncture stimulations on insulin secretion. Bull. Meiji Coll. Oriental Med., Vol.1, 89–94, 1985.

Vatsujl

Yoshida

Terasawa

., Does acupuncture to “Quehl” promote the insulin secretion. Bull. Meiji Coll. Oriental Med., Vol.3, 9–14, 1987

10.

Klyofune

Kajiyama

Ishizuka

., The effect of acupuncture stimulation on Insulin secretion in rats using the bilateral Quchi (LI, 11) points. Bull. Meiji Coll. Oriental Med., Vol.7, 43–48, 1990.

11.

Niijima

Neuronal control of pancreatic hormone secretion. Taisha, Vol.22, 1123–1134, 1985.

12.

Ikeda

Kawatani

and Takeshige

Increase of blood sugar with electrical stimulation of the upper abdominal skin via inhibition of pancreatic vagus activity. Jpn. J. Physiol. Vol.41 1991 (in press)

13.

Asamoto

and Takeshige

Activation of the satiety center by auricular acupuncture point stimulation. Jpn. J. Phvs1ol. Vol.41 1991 (in press)