The c-fos proto-oncogene encodes a nuclear phosphoprotein, Fos which has been proposed to be a “third messenger” coupling short terra extracellular signals to long term alteration in cell function. Using double labeling immunocytochemistry, the present work demonstrated the co-localization of Fos protein and serotonin in the nucleus raphe dorsalis, nucleus raphe centralis superior and rostral ventromedial medulla. The results pose an interesting problem, the possible relation of Fos protein to the biosynthesis of serotonin, awaiting further investigation.
BullittE.Expression of c-fos like protein as a marker for neuronal activity following noxious stimulation in the rat. J. Comp. Neurol., 296:517–530, 1990.
2.
ChengK. L.WeiC. P.LinY.M.ChouL. H.LoC. L. and ChangT. C.Effect of stimulation of midbrain raphe nuclei on discharge of pain sensitive cells in nucleus parafascicularlis of thalamus and its significance in acupuncture analgesia. Acta physiol. sin., 31:209–218, 1979.
3.
CurranT., and MorganJ.T.Superinduction of c-fos by nerve growth factor in the presence of peripherally active benzodiazepines. Science, 229:1265–1268, 1985.
4.
DuH. J.ShenE.DongX.W., JiangZ.H., MaW.X., FuY.F., JinG.S., ZhangZ.D. and HanY.F., Effect on acupuncture analgesia by 5, 6-dihydroxytryptamine in cat, a neurophysiological, neurochemical and fluorescence histochemical study. Acta zool. sin., 24:11–20, 1978.
5.
HeL.Involvement of endogeneous opioid peptides in acupuncture analgesia. Pain, 31:99–121, 1987.
6.
HeL.ZhouJ. X.GaoΜ., DuJ. and DaC., Expression of c-fos protein in the rat central nervous system in response to electroacupuncture. Chinese J. Physiol. Sci., 1992, in press.
7.
HuntS.P.PiniA. and EvanG.Induction of c-fos-like protein in spinal cord neurons following sensory stimulation. Nature, 328:632–634, 1987.
8.
JacobowitzD.M. and Palkovits, Miklos, Topographic atlas of catecholamine and acetylcholinesterase contzining neurons in the rat brain, II. Hindbrain (mesencephalon, rhombencephalon) J. Comp. Neurol., 157:29–42, 1974.
9.
NoguchiK.KowalskiK.TraubR.SolodkinA.ladarola, Μ. J. and Puda, Μ.A., Dynorphin expression and Fos-like immuno-reactivity following inflammation induced hyperalgesia are co-localized in spinal cord neurons. Mol. Brain Res., 10:227–223, 1991.
10.
SambucettiL. C. and CurranT.The Fos protein complex is associated with DNA in isolated nuclei and binds to DNA cellulose. Science, 234:1417–1419, 1986.
