Article Commentary: Dolutegravir Monotherapy: When Should Clinical Practice be Clinical Research?

Oldenbuettel C. , Wolf E. , Ritter A. Dolutegravir monotherapy as treatment de-escalation in HIV-infected adults with virological control: DoluMono cohort results. Antivir Ther 2016; doi: 10.3851/IMP3082.

Rojas J. , Blanco J.L. , Marcos M.A. Dolutegravir monotherapy in HIV-infected patients with sustained viral suppression. J Antimicrob Chemother 2016; 71: 1975–1981.

Katlama C. , Soulié C. , Caby F. Dolutegravir as monotherapy in HIV-1-infected individuals with suppressed HIV viraemia. J Antimicrob Chemother 2016; 71: 2646–2650.

Gubavu C. , Prazuck T. , Niang M. Dolutegravir-based monotherapy or dual therapy maintains a high proporition of viral suppression even in highly-experience HIV-1-infected patients. J Antimicrob Chemother 2016; 71: 1046–1050.

Rojas J. , Blanco J.L. , Lonca M. Dolutegravir monotherapy in HIV-infected patients with sustained viral suppression: a 24-week pilot study. 15th European AIDS Conference. 21–24 October 2015, Barcelona, Spain. Abstract LBPS4/2.

Cahn P. , Rolon M.J. , Figueroa M.I. , Gun A. , Patterson P. , Sued O. Dolutegravir-lamivudine as initial therapy in HIV-infected, ARV naive patients: 48 week results of the PADDLE trial. 21st International AIDS Conference. 18–22 July 2016, Durban, South Africa. Abstract FRAB004LB.

Figueroa M.I. , Sued O. , Patterson P. , Gun A. , Rolon M.J. , Cahn P. Dolutegravir-lamivudine as initial therapy in HIV-infected, ARV naive patients: first results of the PADDLE trial. 15th European AIDS Conference. 21–24 October 2015, Barcelona, Spain. Abstract LBPS4/1.

Günthard H.F. , Saag M.S. , Benson C.A. Antiretroviral drugs for treatment and prevention of HIV infection in adults: 2016 recommendations of the International Antiviral Society-USA Panel. JAMA 2016; 316: 191–210.

Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Department of Health and Human Services. (Accessed 15 September 2016.) Available from http://www.aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdf.