Virological Outcomes of EVG/COBI/FTC/TDF and EVG/COBI/FTC/TAF in Antiretroviral-Naive HIV-1-Infected Participants with Baseline HIV-1 RNA ≥1,000,000 Copies/ml: A Post Hoc Analysis of Phase III Clinical Trials
Free accessLetterFirst published online January, 2018
Virological Outcomes of EVG/COBI/FTC/TDF and EVG/COBI/FTC/TAF in Antiretroviral-Naive HIV-1-Infected Participants with Baseline HIV-1 RNA ≥1,000,000 Copies/ml: A Post Hoc Analysis of Phase III Clinical Trials
AdamsJ.L., ByrneD., PepeR., GrayA., BaxterJ.D.Virological failure in two patients with HIV-1 RNA viral loads >1,000,000 copies/ml initiated on elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate.Antivir Ther2016; 21: 175–180.
2.
SaxP.E., DeJesusE., MillsA.Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir versus co-formulated efavirenz, emtricitabine, and tenofovir for initial treatment of HIV-1 infection: a randomised, double-blind, Phase 3 trial, analysis of results after 48 weeks.Lancet2012; 379: 2439–2448.
3.
ZolopaA., SaxP.E., DeJesusE.A randomized double-blind comparison of coformulated elvitegravir/cobicistat/ emtricitabine/tenofovir disoproxil fumarate versus efavirenz/emtricitabine/tenofovir disoproxil fumarate for initial treatment of HIV-1 infection: analysis of week 96 results.J Acquir Immune Defic Syndr2013; 63: 96–100.
4.
WohlD.A., CohenC., GallantJ.E.A randomized, double-blind comparison of single-tablet regimen elvitegravir/cobicistat/emtricitabine/tenofovir DF versus single-tablet regimen efavirenz/emtricitabine/tenofovir DF for initial treatment of HIV-1 infection: analysis of week 144 results.J Acquir Immune Defic Syndr2014; 65: e118–121.
5.
DeJesusE., RockstrohJ., HenryK.Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate versus ritonavir-boosted atazanavir plus co-formulated emtricitabine and tenofovir disoproxil fumarate for initial treatment of HIV-1 infection: a randomised, double-blind, Phase 3, non-inferiority trial.Lancet2012; 379: 2429–2438.
6.
RockstrohJ.K., DeJesusE., HenryK.Randomized, double-blind comparison of coformulated elvitegravir/ cobicistat/emtricitabine/tenofovir DF vs ritonavir-boosted atazanavir plus coformulated emtricitabine and tenofovir DF for initial treatment of HIV-1 infection: analysis of week 96 results.J Acquir Immune Defic Syndr2013; 62: 483–486.
7.
ClumeckN., MolinaJ.M., HenryK.A randomized, double-blind comparison of single-tablet regimen elvitegravir/cobicistat/emtricitabine/tenofovir DF vs ritonavir-boosted atazanavir plus emtricitabine/tenofovir DF for initial treatment of HIV-1 infection: analysis of week 144 results.J Acquir Immune Defic Syndr2014; 65: e121–124.
8.
SaxP.E., WohlD., YinM.T.Tenofovir alafenamide versus tenofovir disoproxil fumarate, coformulated with elvitegravir, cobicistat, and emtricitabine, for initial treatment of HIV-1 infection: two randomised, double-blind, Phase 3, non-inferiority trials.Lancet2015; 385: 2606–2615.
9.
WohlD., OkaS., ClumeckN.Brief report: a randomized, double-blind comparison of tenofovir alafenamide versus tenofovir disoproxil fumarate, each coformulated with elvitegravir, cobicistat, and emtricitabine for initial HIV-1 treatment: week 96 results.J Acquir Immune Defic Syndr2016; 72: 58–64.
10.
SquiresK., KityoC., HodderS.Integrase inhibitor versus protease inhibitor based regimen for HIV-1 infected women (WAVES): a randomised, controlled, double-blind, Phase 3 study.Lancet HIV2016; 3: e410–e420.
11.
WhiteK.L., RaffF., MillerM.D.Resistance analyses of integrase strand transfer inhibitors within Phase 3 clinical trials of treatment-naive patients.Viruses2014; 6: 2858–2879.
12.
ChaoC., TangB., HurleyL.Risk factors for short-term virologic outcomes among HIV-infected patients undergoing regimen switch of combination antiretroviral therapy.AIDS Res Hum Retroviruses2012; 28: 1630–1636.
13.
Panel on Antiretroviral Guidelines for Adults and Adolescents.Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents. Developed by the DHHS Panel on Antiretroviral Guidelines for Adults and Adolescents – A Working Group of the Office of AIDS Research Advisory Council (OARAC). (Updated 14 July 2016. Accessed 14 July 2016.) Available from http://aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdf.
14.
LepikK.J., HarriganP.R., YipB.Emergent drug resistance with integrase strand transfer inhibitor-based regimens.AIDS2017; 31: 1425–1434.
15.
KrawczykC.S., FunkhouserE., KilbyJ.M., VermundS.H.Delayed access to HIV diagnosis and care: special concerns for the southern United States.AIDS Care2006; 18Suppl 2: S35–S44.
16.
MbuagbawL., SivaramalingamB., NavarroT.Interventions for enhancing adherence to antiretroviral therapy (ART): a systematic review of high quality studies.AIDS Patient Care STDS2015; 29: 248–266.