Measurements of inspiratory capacity (IC) and vital capacity (VC) are used to recognize dynamic hyperinflation, but appropriate reference values are required to achieve accurate clinical interpretations. Altitude above sea level is a potential determining factor for lung volumes, including IC and VC.
OBJECTIVE:
To describe IC and VC for healthy people who live in Mexico City at an altitude of 2,240 m above sea level.
METHODS:
Healthy subjects ages 9–81 y completed slow spirometry by following 2005 American Thoracic Society/European Respiratory Society standards. Once associations were explored, linear regression models were constructed and values were compared with those from previously published equations.
RESULTS:
A total of 441 healthy subjects (55.1% women) participated. The mean age was 32 y (minimum age, 9 y; maximum age, 81 y). IC and VC measurements were associated with sex, age, height, and weight. An accelerated increase in IC and VC was evident from 9 to 20 y of age, followed by a gradual decrease in both sexes. In general, IC was higher in our population than predicted by previously published reference equations.
CONCLUSIONS:
IC in healthy people at 2,240 m above sea level was higher than that of previous reports about European and Latin-American subjects of the same height, sex, and age who were at sea level. The present study provided robust reference values for persons who lived at a moderate altitude.
WangerJ, ClausenJL, CoatesA, PedersenOF, BrusascoV, BurgosF, et al. Standardisation of the measurement of lung volumes. Eur Respir J, 2005; 26(3):511–22.
2.
StocksJ, QuanjerPH. ATS Workshop on Lung Volume Measurements. Official Statement of The European Respiratory Society. Reference values for residual volume, functional residual capacity and total lung capacity. Eur Respir J, 1995; 8(3):492–506.
3.
TantucciC, PinelliV, CossiS, GueriniM, DonatoF, GrassiV. SARA Study Group. Reference values and repeatability of inspiratory capacity for men and women aged 65–85. Respir Med, 2006; 100(5):871–877.
4.
CasanovaC, CoteC, de TorresJP, Aguirre-JaimeA, MarinJM, Pinto-PlataV, et al. Inspiratory to total lung capacity ratio predicts mortality in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 2005; 171(6):591–597.
5.
PellegrinoR, ViegiG, BrusascoV, CrapoRO, BurgosF, CasaburiR, et al. Interpretative strategies for lung function tests. Eur Respir J, 2005; 26(5):948–968.
6.
TantucciC, DonatiP, NicosiaF, BertellaE, RedolfiS, De VecchiM, et al. Inspiratory capacity predicts mortality in patients with chronic obstructive pulmonary disease. Respir Med, 2008; 102(4):613–619.
7.
MillerMR, HankinsonJ, BrusascoV, BurgosF, CasaburiR, CoatesA, et al. ATS/ERS Task Force. Standardisation of spirometry. Eur Respir J, 2005; 26(2):319–338.
8.
BarrosAR, PiresMB, RaposoNM. Importance of slow vital capacity in the detection of airway obstruction. J Bras Pneumol, 2013; 39(3):317–322.
9.
YuanW, HeX, XuQF, WangH-Y, CasaburiR. Increased difference between slow and forced vital capacity is associated with reduced exercise tolerance in COPD patients. BMC Pulm Med, 2014; 14:16.
10.
EnrightPL, KronmalRA, HigginsM, SchenkerM, HaponikEF. Spirometry reference values for women and men 65 to 85 years of age. Cardiovascular health study. Am Rev Respir Dis, 1993; 147(1):125–133.
Pérez-PadillaR. Population distribution residing at different altitudes: implications for hypoxemia. Arch Med Res, 2002; 33(2):162–166.
13.
Pérez-PadillaJR, Regalado-PinedaJ, Vázquez-GarcíaJC. Reproducibility of spirometry in Mexican workers and international reference values. Salud Publica Mex, 2001; 43(2):113–121.
14.
FrisanchoAR. Developmental functional adaptation to high altitude: review. Am J Hum Biol, 2013; 25(2):151–168.
15.
WilliamsJHJr, BencowitzHZ. Differences in plethysmographic lung volumes. Effects of linked vs unlinked spirometry. Chest, 1989; 95(1):117–123.
16.
HankinsonJL, OdencrantzJR, FedanKB. Spirometric reference values from a sample of the general U.S. population. Am J Respir Crit Care Med, 1999; 159(1):179–187.
17.
RocaJ, BurgosF, BarberàJA, SunyerJ, Rodriguez-RoisinR, CastellsaguéJ, et al. Prediction equations for plethysmographic lung volumes. Respir Med, 1998; 92(3):454–460.
18.
NederJA, AndreoniS, Castelo-FilhoA, NeryLE. Reference values for lung function tests. I. Static volumes. Braz J Med Biol Res, 1999; 32(6):703–717.
19.
LisboaC, LeivaA, PinochetR, RepettoP, BorzoneG, DíazO. Reference values for inspiratory capacity in healthy nonsmokers over age 50 years. Arch Bronconeumol, 2007; 43(9):485–489.
20.
Garcia-RioF, DorghamA, PinoJM, VillasanteC, Garcia-QueroC, Alvarez-SalaR. Lung volume reference values for women and men 65 to 85 years of age. Am J Respir Crit Care Med, 2009; 180(11):1083–1091.
21.
MarshS, AldingtonS, WilliamsM, WeatherallM, ShirtcliffeP, McNaughtonA, et al. Complete reference ranges for pulmonary function tests from a single New Zealand population. N Z Med J, 2006; 119(1244):U2281.
22.
CaussadeS, PulgarD, Vega-BricenoL, VivianiP, DiazC, ContrerasI, SanchezI. Plethysmographic lung volumes in normal Chilean children and adolescents. Pediatr Pulmonol, 2008; 43(9):866–873.
23.
CorderoPJ, MoralesP, BenllochE, MiravetL, CebrianJ. Static lung volumes: reference values from a Latin population of Spanish descent. Respiration, 1999; 66(3):242–250.
24.
QuanjerPH, StanojevicS, ColeTJ, BaurX, HallGL, CulverBH, et al. ERS Global Lung Function Initiative. Multi-ethnic reference values for spirometry for the 3–95-yr age range: the global lung function 2012 equations. Eur Respir J, 2012; 40(6):1324–1343.
25.
SchoeneRB. Limits of human lung function at high altitude. J Exp Biol, 2001; 204(Pt 18):3121–3127.
26.
CogoA. The lung at high altitude. Multidiscip Respir Med, 2011; 6(1):14–15.
27.
KiyamuM, BighamA, ParraE, León-VelardeF, Rivera-ChiraM, BrutsaertTD. Developmental and genetic components explain enhanced pulmonary volumes of female peruvian quechua. Am J Phys Anthropol, 2012; 148(4):534–542.
28.
LlapurCJ, MartínezMR, CaramMM, BonillaF, CabanaC, YuZ, TepperRS. Increased lung volume in infants and toddlers at high compared to low altitude. Pediatr Pulmonol, 2013; 48(12):1224–1230.
29.
BrodyJS, LahiriS, SimpserM, MotoyamaEK, VelasquezT. Lung elasticity and airway dynamics in Peruvian natives to high altitude. J Appl Physiol, 1977; 42(2):245–251.
30.
PataO, AtişS, Utku OzA, YaziciG, TokE, PataC, et al. The effects of hormone replacement therapy type on pulmonary functions in postmenopausal women. Maturitas, 2003; 46(3):213–218.
JanssensJP, PacheJC, NicodLP. Physiological changes in respiratory function associated with ageing. Eur Respir J, 1999; 13(1):197–205.
33.
LumS, StocksJ, StanojevicS, WadeA, RobinsonP, GustafssonP, et al. Age and height dependence of lung clearance index and functional residual capacity. Eur Respir J, 2013; 41(6):1371–1377.
34.
VerbanckS, ThompsonBR, SchuermansD, KalsiH, BiddiscombeM, Stuart-AndrewsC, et al. Ventilation heterogeneity in the acinar and conductive zones of the normal ageing lung. Thorax, 2012; 67(9):789–795.
35.
O'DonnellDE, GuenetteJA, MaltaisF, WebbKA. Decline of resting inspiratory capacity in COPD: the impact on breathing pattern, dyspnea, and ventilatory capacity during exercise. Chest, 2012; 141(3):753–762.
36.
GuenetteJA, ChinRC, CoryJM, WebbKA, O'DonnellDE. Inspiratory Capacity during Exercise: Measurement, Analysis, and Interpretation. Pulm Med, 2013; 2013:95608.
TrigoMJM, Sánchez-Barón. Valoración funcional del paciente con EPOC [Functional assessment of the patient with COPD]. Arch Bronconeumol, 2005; 41:18–23.
39.
Di MarcoF, Milic-EmiliJ, BoveriB, CarlucciP, SantusP, CasanovaF, et al. Effect of inhaled bronchodilators on inspiratory capacity and dyspnea at rest in COPD. Eur Respir J, 2003; 21(1):86–94.
40.
RichterMJ, TiedeH, MortyRE, VoswinckelR, SeegerW, SchulzR, et al. The prognostic significance of inspiratory capacity in pulmonary arterial hypertension. Respiration, 2014; 88(1):24–30.
41.
TorénK, OlinAC, LindbergA, VikgrenJ, SchiölerL, BrandbergJ, et al. Vital capacity and COPD: the Swedish CArdioPulmonary bioImage Study (SCAPIS). Int J Chron Obstruct Pulmon Dis, 2016; 11:927–933.
42.
Martínez-BriseñoD, Fernández-PlataR, Gochicoa-RangelL, Torre-BouscouletL, Rojas-MartínezR, MendozaL, et al. Longitudinal lung function growth of Mexican children compared with international studies. PLoS One, 2013; 8(10):e77403.
