FeeleyTW, Du MoulinGC, Hedley-WhyteJ, BushnellLS, GilbertJP, FeingoldDS. Aerosol polymyxin and pneumonia in seriously ill patients. N Engl J Med, 1975; 293(10):471-475.
2.
WongFJ, DudneyT, DhandR. Aerosolized antibiotics for treatment of pneumonia in mechanically ventilated subjects. Respir Care, 2019; 64(8):962-979.
3.
Solé-LleonartC, RoubyJ-J, BlotS, PoulakouG, ChastreJ, PalmerLB, et al. Nebulization of anti-infective agents in invasively mechanically ventilated adults: a systematic review and meta-analysis. Anesthesiology, 2017; 126(5):890-908.
4.
PalmerLB. Ventilator-associated infection: the role for inhaled antibiotics. Curr Opin Pulm Med, 2015; 21(3):239-242.
5.
PalmerLB. Inhaled antibiotics for ventilator-associated infections. Infect Dis Clin North Am, 2017; 31(3):577-591.
6.
DhandR. The rationale and evidence for use of inhaled antibiotics to control Pseudomonas aeruginosa infection in non-cystic fibrosis bronchiectasis. J Aerosol Med Pulm Drug Deliv, 2018; 31(3):121-138.
7.
LuytC-E, HékimianG, BréchotN, ChastreJ. Aerosol therapy for pneumonia in the intensive care unit. Clin Chest Med, 2018; 39(4):823-836.
8.
PalmerLB. Aerosolized antibiotics in the intensive care unit. Clin Chest Med, 2011; 32(3):559-574.
9.
NiedermanMS, AlderJ, BassettiM, BoatengF, CaoB, CorkeryK, et al. Inhaled amikacin adjunctive to intravenous standard-of-care antibiotics in mechanically ventilated patients with Gram-negative pneumonia (INHALE): a double-blind, randomized, placebo-controlled, phase 3 superiority trial. Lancet Infect Dis, 2020; 20(3):330-340.
10.
KollefMH, RicardJD, RouxD, FrancoisB, IschakiE, RozgonyiZ, et al. A randomized trial of the amikacin fosfomycin inhalation system for the adjunctive therapy of Gram-negative ventilator-associated pneumonia. IASIS Trial. Chest, 2017; 151(6):1239-1246.
11.
KalilAC, MeterskyML, KlompasM, MuscedereJ, SweeneyDA, PalmerLB, et al. Management of adults with hospital-acquired and ventilator-associated pneumonia: 2016 clinical practice guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Clin Infect Dis, 2016; 63(5):e61-e111.
12.
DroegeCA, ErnstNE, FoertschMJ, BradshawPG, GlobkeAE, GomaaD, et al. Assessment of detectable serum tobramycin concentrations in patients receiving inhaled tobramycin for ventilator-associated pneumonia. Respir Care, 2021; 67(1):16-23.
13.
de VeldeF, EmontsM, VerbruggenS, van der SijsH. High tobramycin serum concentrations after tobramycin inhalation in a child with renal failure. J Antimicrob Chemother, 2014; 69(11):3163-3164.
14.
GauthierT, WaskoJ, UngerN, AbboL, FernandezM, AragonL, et al. Cost reduction of inhaled tobramycin by use of preservative-free intravenous tobramycin given via inhalation. Antibiotics (Basel), 2015; 5(1):2.
15.
AlothmanGA, AlsaadiMM, HoBL, HoSL, DupuisA, CoreyM, CoatesAL. Evaluation of bronchial constriction in children with cystic fibrosis after inhaling two different preparations of tobramycin. Chest, 2002; 122(3):930-934.
16.
DrobnicME, SuñéP, MontoroJB, FerrerA, OrriolsR. Inhaled tobramycin in non-cystic fibrosis patients with bronchiectasis and chronic bronchial infection with Pseudomonas aeruginosa. Ann Pharmacother, 2005; 39(1):39-44.
17.
DhandR. The role of aerosolized antimicrobials in the treatment of ventilator-associated pneumonia. Respir Care, 2007; 52(7):866-884.
18.
RelloJ, Solé-LleonartC, RoubyJJ, ChastreJ, BlotS, PoulakouG, et al. Use of nebulized antimicrobials for the treatment of respiratory infections in invasively mechanically ventilated adults: a position paper from the European Society of Clinical Microbiology and Infectious Diseases. Clin Microbiol Infect, 2017; 23(9):629-639.
19.
RelloJ, RoubyJJ, Solé-LleonartC, ChastreJ, BlotS, LuytCE, et al. Key considerations on nebulization of antimicrobial agents to mechanically ventilated patients. Clin Microbiol Infect, 2017; 23(9):640-646.
20.
DhandR. How should aerosols be delivered during invasive mechanical ventilation?. Respir Care, 2017; 62(10):1343-1367.
21.
AriA, AtalayOT, HarwoodR, SheardMM, AljamhanEA, FinkJB. Influence of nebulizer type, position, and bias flow on aerosol drug delivery in simulated pediatric and adult lung models during mechanical ventilation. Respir Care, 2010; 55(7):845-851.
