Abstract
Background:
The purpose of this study is to identify variables associated with extubation success in extremely preterm neonates weaned from volume-targeted ventilation.
Methods:
We retrospectively evaluated 84 neonates ≤28 weeks’ gestational age, on their first elective extubation. Logistic regression was used to determine variables associated with successful extubation, defined as non-reintubation within seven days.
Results:
Twenty-six (31%) neonates who failed, compared to 58 (69%) who succeeded extubation, were predominantly males and of lower birth weight; before extubation, they had lower weight, higher mean airway pressure (MAP), and lower pH. They also had higher rates of patent ductus arteriosus and bronchopulmonary dysplasia. Female sex (OR 1.15, 95%CI 1.01-9.10), higher pre-extubation weight (OR 1.29, 95%CI 1.05-1.59), lower pre-extubation MAP (OR 0.49, 95%CI 0.33-0.73), and higher pre-extubation pH (OR 2.54, 95%CI 1.54-4.19) were associated with successful extubation.
Conclusions:
In preterm neonates, female sex, higher pre-extubation weight, lower pre-extubation MAP, and higher pre-extubation pH were predictors of successful extubation.
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