Extracapillary Glomerulonephritis Overlaid on Primary Amyloidosis AL: Case Report

Amyloidosis is a disease characterized by the deposition of extracellular protein called amyloid. There are two types of amiloidosis: primary AL and secondary AA. Renal involvement is frequent and it occasionally presents as renal failure progressive sustained by extracapillary glomerulonephritis. The rare cases reported in the literature are related to amyloidosis secondary to rheumatoid arthritis.

We report case of a 46 year old woman, smoker with autoimmune hypothyroidism, came to our observation for nephrotic syndrome, hypertension, anemia, acute renal failure. Renal biopsy showed extracapillary glomerulonephritis overlaid on primary amyloidosis AL.

Despite the early start of drug therapy, the patient died after about six months.