Diurnal Variation of the Tear Osmolarity in Normal Subjects Measured by a New Microchip System

Abstract

Purpose

To show the diurnal variation of tear osmolarity in normal subjects.

Methods

Thirty volunteers were recruited. Tear osmolarity was measured with TearLab osmolarity system at 3-hour regular intervals between 8:00 AM and 5:00 PM. One-way analysis of variance test was used for statistical analysis.

Results

Thirty healthy volunteers (all men) with a mean age of 29.6±4.3 years (range 18-45) were recruited. The difference between measurements at 8:00 AM and 11:00 AM, 8:00 AM and 2:00 PM, 8:00 AM and 5:00 PM, 11:00 AM and 2:00 PM, 11:00 AM and 5:00 PM, and 2:00 PM and 5:00 PM were not statistically significant (one-way analysis of variance test, p>0.05).

Conclusions

In normal subjects, tear osmolarity seems to have a stable profile during the daytime.

Keywords

Diurnal variation Dry eye Osmolarity

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