Tirofiban as Treatment for Acute Retinal Artery Occlusion following Internal Carotid Artery Flow Diverter Implantation

Abstract

Purpose

To report a favorable outcome of branch retinal artery occlusion (BRAO) treated by means of early administration of tirofiban, a glycoprotein IIb-IIIa platelet receptor inhibitor.

Methods

Case report.

Results

A 65-year-old woman developed dramatic visual impairment in her left eye secondary to BRAO after left internal carotid artery endovascular reconstruction with flow diverter stent implant; visual acuity was hand motion. A dose of intravenous tirofiban was injected 10 minutes after symptoms onset. Fourteen hours after drug infusion, retinal fluorescein angiography revealed a well-perfused macula with a partial reperfusion of the inferior temporal branch of the central retinal artery; visual acuity was 20/20 in both eyes.

Conclusions

This case supports the effectiveness of tirofiban in secondary BRAO in neurosurgery and may open its usage to further research.

Keywords

Carotid aneurysm Glycoprotein IIb-IIIa inhibitors Retinal artery occlusion Tirofiban

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