To compare retinal nerve fiber layer thickness (RNFLT) measurements by Stratus and Cirrus optical coherence tomography (OCT) and to evaluate agreement between the 2 instruments in retrobulbar optic neuritis (RON), nonarteritic ischemic optic neuropathy (NAION), and healthy controls.
Methods
A total of 89 eyes with RON, 92 with NAION (6 to 12 months after diagnosis of acute disease), and 159 control eyes were studied. Average RNFLT was measured by Stratus and Cirrus OCTs. Comparisons among groups were performed by analysis of variance. Agreement between the 2 instruments was assessed using intraclass correlation coefficient (ICC) with 95% confidence interval (CI) and Bland-Altman analysis. Statistical significance was set at p≤0.05.
Results
Average RNFLT was lower in NAION eyes than in RON and control ones using both OCT devices (60.0 ± 1.2, 69.9 ± 1.2, and 97.4 ± 0.9 μm, p<0.001 by Cirrus; 49.7 ± 1.5, 65.9 ± 1.9, and 99.2 ± 1.3 μm, p<0.001 by Stratus). The RNFLT values were higher with Cirrus than with Stratus in NAION (+10.30 μm, confidence interval [CI] 7.82-12.79 μm) and RON (+4.01 μm, CI 1.32-6.70 μm) eyes, and slightly lower in control ones (-1.75 μm, CI -3.51 to 0.01 μm). A stronger agreement between the 2 instruments was found in control and RON eyes than in NAION ones (ICC 0.682, CI 0.566-0.771; 0.635, CI 0.467-0.758; 0.321, CI 0.132-0.472, respectively).
Conclusions
Both Stratus and Cirrus OCT can identify RNFLT reduction in previous RON and NAION. Absolute RNFLT values differ between the 2 instruments; hence they are not to be considered interchangeable.
GarciaTTourbahASetroukÉDucasseAArndtC[Optical coherence tomography in neuro-ophthalmology].J Fr Ophtalmol2012;35 (6):454–466
2.
ContrerasINovalSRebolledaGMuñoz-NegreteFJFollow-up of nonarteritic anterior ischemic optic neuropathy with optical coherence tomography.Ophthalmology2007;114 (12):2338–2344
3.
FrohmanEMFujimotoJGFrohmanTCCalabresiPACutterGBalcerLJOptical coherence tomography: a window into the mechanisms of multiple sclerosis.Nat Clin Pract Neurol2008;4 (12):664–675
4.
AlasilTTanOLuATHuangDSadunAACorrelation of Fourier domain optical coherence tomography retinal nerve fiber layer maps with visual fields in nonarteritic ischemic optic neuropathy.Ophthalmic Surg Lasers Imaging2008;394 SupplS71–S79
5.
SubeiAMEggenbergerEROptical coherence tomography: another useful tool in a neuro-ophthalmologist's armamentarium.Curr Opin Ophthalmol2009;20 (6):462–466
6.
PetzoldAde BoerJFSchipplingS et al. Optical coherence tomography in multiple sclerosis: a systematic review and meta-analysis.Lancet Neurol2010;9 (9):921–932
7.
LamirelCNewmanNJBiousseVOptical coherence tomography (OCT) in optic neuritis and multiple sclerosis.Rev Neurol (Paris)2010;166 (12):978–986
8.
WarnerCVSycSBStankiewiczAM et al. The impact of utilizing different optical coherence tomography devices for clinical purposes and in multiple sclerosis trials.PLoS One2011;6 (8): e22947
9.
CostelloFEKlistornerAKardonROptical coherence tomography in the diagnosis and management of optic neuritis and multiple sclerosis.Ophthalmic Surg Lasers Imaging201142SupplS28–S40
10.
KernstockCFriebeKTonagelF[Applications of optical coherence tomography (OCT) in neuro-ophthalmology].Klin Monbl Augenheilkd2013;230 (11):1097–1105
11.
BalcerLJClinical trials to clinical use: using vision as a model for multiple sclerosis and beyond.J Neuroophthalmol2014;34SupplS18–S23
12.
BalkLJPetzoldACurrent and future potential of retinal optical coherence tomography in multiple sclerosis with and without optic neuritis.Neurodegener Dis Manag2014;4 (2):165–176
13.
RebolledaGDiez-AlvarezLCasadoA et al. OCT: New perspectives in neuro-ophthalmology.Saudi J Ophthalmol2015;29 (1): 9–25
14.
KostanyanTWollsteinGSchumanJSNew developments in optical coherence tomography.Curr Opin Ophthalmol201526 (2):110–115
15.
VizzeriGWeinrebRNGonzalez-GarciaAO et al. Agreement between spectral-domain and time-domain OCT for measuring RNFL thickness.Br J Ophthalmol2009;93 (6):775–781
16.
SungKRKimDYParkSBKookMSComparison of retinal nerve fiber layer thickness measured by Cirrus HD and Stratus optical coherence tomography.Ophthalmology2009;116 (7):1264–1270, 1270.e1
17.
KnightOJChangRTFeuerWJBudenzDLComparison of retinal nerve fiber layer measurements using time domain and spectral domain optical coherent tomography.Ophthalmology2009;116 (7):1271–1277
18.
ParkSBSungKRKangSYKimKRKookMSComparison of glaucoma diagnostic Capabilities of Cirrus HD and Stratus optical coherence tomography.Arch Ophthalmol2009;127 (12):1603–1609
19.
Moreno-MontañésJOlmoNAlvarezAGarcíaNZarranz-VenturaJCirrus high-definition optical coherence tomography compared with Stratus optical coherence tomography in glaucoma diagnosis.Invest Ophthalmol Vis Sci2010;51 (1):335–343
20.
HongSSeongGJKimSSKangSYKimCYComparison of peripapillary retinal nerve fiber layer thickness measured by spectral vs.time domain optical coherence tomography. Curr Eye Res2011;36 (2):125–134
21.
HuangLFanNShenXHeJComparison of the diagnostic ability of retinal nerve fiber layer thickness measured using time domain and spectral domain optical coherence tomography in primary open angle glaucoma.Eye Sci2011;26 (3):132–137, 142
22.
LeungCKChiuVWeinrebRN et al. Evaluation of retinal nerve fiber layer progression in glaucoma: a comparison between spectral-domain and time-domain optical coherence tomography.Ophthalmology2011;118 (8):1558–1562
23.
RebolledaGGarcía-GarcíaAWon KimHRMuñoz-NegreteFJComparison of retinal nerve fiber layer measured by time domain and spectral domain optical coherence tomography in optic neuritis.Eye (Lond)2011;25 (2):233–238
24.
WatsonGMKeltnerJLChinEKHarveyDNguyenAParkSSComparison of retinal nerve fiber layer and central macular thickness measurements among five different optical coherence tomography instruments in patients with multiple sclerosis and optic neuritis.J Neuroophthalmol2011;31 (2):110–116
25.
LangeAPSadjadiRSaeediJLindleyJCostelloFTraboulseeALTime-Domain and Spectral-Domain Optical Coherence Tomography of Retinal Nerve Fiber Layer in MS Patients and Healthy Controls.J Ophthalmol2012;2012564627
26.
KimCYJungJWLeeSYKimNRAgreement of retinal nerve fiber layer color codes between Stratus and Cirrus OCT according to glaucoma severity.Invest Ophthalmol Vis Sci2012;53 (6):3193–3200
27.
LeeKHKangMGLimHKimCYKimNRA formula to predict spectral domain optical coherence tomography (OCT) retinal nerve fiber layer measurements based on time domain OCT measurements.Korean J Ophthalmol2012;26 (5):369–377
28.
PatelNBWheatJLRodriguezATranVHarwerthRSAgreement between retinal nerve fiber layer measures from Spectralis and Cirrus spectral domain OCT.Optom Vis Sci2012;89 (5):E652–E666
29.
RebolledaGGonzález-LópezJJMuñoz-NegreteFJOblancaNCosta-FrossardLÁlvarez-CermeñoJCColor-code agreement among stratus, cirrus, and spectralis optical coherence tomography in relapsing-remitting multiple sclerosis with and without prior optic neuritis.Am J Ophthalmol2013;155 (5): 890–897
30.
AngmoDBhartiyaSMishraSKSharmaRPoojariADadaTComparative evaluation of time domain and spectral domain optical coherence tomography in retinal nerve fiber layer thickness measurements.Nepal J Ophthalmol2014;6 (2):185–191
31.
BlandJMAltmanDGStatistical methods for assessing agreement between two methods of clinical measurement.Lancet1986;1 (8476):307–310
32.
RebolledaGSánchez-SánchezCGonzález-LópezJJContrerasIMuñoz-NegreteFJPapillomacular bundle and inner retinal thicknesses correlate with visual acuity in nonarteritic anterior ischemic optic neuropathy.Invest Ophthalmol Vis Sci2015;56 (2):682–692
33.
SuhMHKimSHParkKH et al. Comparison of the correlations between optic disc rim area and retinal nerve fiber layer thickness in glaucoma and nonarteritic anterior ischemic optic neuropathy.Am J Ophthalmol2011;151 (2):277–86.e1
