To evaluate the changes in retinal nerve fiber layer thickness (RNFLT), ganglion cell layer thickness (GCLT), retinal thickness (RT), and subfoveal choroidal thickness (SFCT) in eyes that received pars plana vitrectomy (PPV) with internal limiting membrane (ILM) peeling for idiopathic macular hole (IMH) and to compare these data with data from fellow eyes and healthy controls.
Methods
This cross-sectional study included 49 subjects. Eighteen eyes that underwent surgery for IMH, 18 fellow eyes, and 31 eyes of the healthy controls were designated as group 1, group 2, and group 3, respectively. The RNFLT, GCLT, RT, and SFCT were measured by using the swept-source optical coherence tomography (SS-OCT) device at last postoperative visit.
Results
The RNFLT was significantly lower in group 1 than group 2 and group 3 (p<0.05). The GCLT was significantly reduced in all sectors in group 1 as compared to group 2 and group 3 (p<0.05). The RT was found to be significantly lower (except in central field) in group 1 than group 2 and group 3 (p<0.05). The SFCT was significantly decreased in group 1 as compared to group 2 and group 3 (p<0.05).
Conclusions
A reduction in the RNFLT, GCLT, RT, and SFCT was observed following PPV with ILM peeling for IMH detected by SS-OCT.
GassJDIdiopathic senile macular hole.Its early stages and pathogenesis. Arch Ophthalmol1988106(5)629–639
2.
ParkDWSipperleyJOSneedSRDugelPUJacobsenJMacular hole surgery with internal-limiting membrane peeling and intravitreous air.Ophthalmology1999106(7)1392–1397discussion 1397-1398.
3.
ThindaSShahRJKimSJTwo-year anatomical and functional outcomes after macular hole surgery: A prospective, controlled study.Ophthalmic Surg Lasers Imaging Retina201546(9)926–934
4.
LeeJWYauGSWooTTYickDWTamVTLaiJSRetinal nerve fiber layer thickness in myopic, emmetropic, and hyperopic children.Medicine (Baltimore)201594(12)e699
5.
ImamuraYFujiwaraTMargolisRSpaideRFEnhanced depth imaging optical coherence tomography of the choroid in central serous chorioretinopathy.Retina200929(10)1469–1473
6.
AhnSJWooSJParkKHChoroidal thickness change following vitrectomy in idiopathic epiretinal membrane and macular hole.Graefes Arch Clin Exp Ophthalmol2016254(6)1059–1067
7.
BabaTYamamotoSKimotoROshitariTSatoEReduction of thickness of ganglion cell complex after internal limiting membrane peeling during vitrectomy for idiopathic macular hole.Eye (Lond)201226(9)1173–1180
8.
CopeteSFlores-MorenoIMonteroJADukerJSRuiz-MorenoJMDirect comparison of spectral-domain and swept-source OCT in the measurement of choroidal thickness in normal eyes.Br J Ophthalmol201498(3)334–338
9.
BertelmannTBlumMKunertKet al.Foveal pit morphology evaluation during optical biometry measurements using a full-eye-length swept-source OCT scan biometer prototype.Eur J Ophthalmol201525(6)552–558
10.
MichalewskaZMichalewskiJAdelmanRAZawiślakENawrockiJChoroidal thickness measured with swept source optical coherence tomography before and after vitrectomy with internal limiting membrane peeling for idiopathic epiretinal membranes.Retina201535(3)487–491
11.
YangZTathamAJWeinrebRNMedeirosFALiuTZangwillLMDiagnostic ability of macular ganglion cell inner plexiform layer measurements in glaucoma using swept source and spectral domain optical coherence tomography.PLoS One201510(5)e0125957
12.
Ruiz-MedranoJFlores-MorenoIPeña-GarcíaPMonteroJADukerJSRuiz-MorenoJMAsymmetry in macular choroidal thickness profile between both eyes in a healthy population measured by swept-source optical coherence tomography.Retina201535(10)2067–2073
13.
RahimyEMcCannelCAImpact of internal limiting membrane peeling on macular hole reopening: A Systematic Review and Meta-Analysis.Retina201636(4)679–687
14.
Spiteri CornishKLoisNScottNet al.Vitrectomy with internal limiting membrane (ILM) peeling versus vitrectomy with no peeling for idiopathic full-thickness macular hole (FTMH).Cochrane Database Syst Rev20136(6)CD009306
15.
LaiTYKwokAKAuAWLamDSAssessment of macular function by multifocal electroretinography following epiretinal membrane surgery with indocyanine green-assisted internal limiting membrane peeling.Graefes Arch Clin Exp Ophthalmol2007245(1)148–154
16.
TadayoniRSvorenovaIErginayAGaudricAMassinPDecreased retinal sensitivity after internal limiting membrane peeling for macular hole surgery.Br J Ophthalmol201296(12)1513–1516
17.
YamashitaTUemuraAKitaHSakamotoTAnalysis of the retinal nerve fiber layer after indocyanine green-assisted vitrectomy for idiopathic macular holes.Ophthalmology2006113(2)280–284
18.
HashimotoYSaitoWFujiyaAet al.Changes in ınner and outer retinal layer thicknesses after vitrectomy for ıdiopathic macular hole: implications for visual prognosis.PLoS One201510(8)e0135925
19.
SeoKHYuSYKwakHWTopographic changes in macular ganglion cell-inner plexiform layer thickness after vitrectomy with indocyanine green-guided internal limiting membrane peeling for idiopathic macular hole.Retina201535(9)1828–1835
20.
HibiNKondoMIshikawaKUenoSKomeimaKTerasakiHTransient increase of retinal nerve fiber layer thickness after macular hole surgery.Int Ophthalmol201434(3)575–581
21.
ClarkABalducciNPichiFet al.Swelling of the arcuate nerve fiber layer after internal limiting membrane peeling.Retina201232(8)1608–1613
22.
EbisawaNMoriKYoneyaSThickness of retinal nerve fiber layer decreases after vitreous surgery for ıdiopathic macular hole.Jpn J Ophthalmol200044(5)573–577
23.
Sellés-NavarroIVillegas-PérezMPSalvador-SilvaMRuiz-GómezJMVidal-SanzMRetinal ganglion cell death after different transient periods of pressure-induced ischemia and survival intervals.A quantitative in vivo study. Invest Ophthalmol Vis Sci199637(10)2002–2014
24.
SevimMSSanisogluHAnalysis of retinal ganglion cell complex thickness after Brilliant Blue-assisted vitrectomy for idiopathic macular holes.Curr Eye Res201338(1)180–184
25.
YipHKLaiTYSoKFKwokAKRetinal ganglion cells toxicity caused by photosensitising effects of intravitreal indocyanine green with illumination in rat eyes.Br J Ophthalmol200690(1)99–102
26.
TobaYMachidaSKurosakaDComparisons of retinal nerve fiber layer thickness after indocyanine green, brilliant blue g, or triamcinolone acetonide-assisted macular hole surgery.J Ophthalmol20142014187308
27.
FujiwaraAShiragamiCFukudaKNomotoHShirakataYShiragaFChanges in subfoveal choroidal thickness of epiretinal membrane and macular hole before and after microincision vitrectomy surgery.Nippon Ganka Gakkai Zasshi2012116111080–1085
28.
SchaalKBPollithySDithmarSIs choroidal thickness of importance in idiopathic macular hole?.Ophthalmologe20121094364–368
29.
ReibaldiMBosciaFAvitabileTet al.Enhanced depth imaging optical coherence tomography of the choroid in idiopathic macular hole: A cross-sectional prospective study.Am J Ophthalmol2011151(1)112–117e2
30.
KumagaiKOginoNFurukawaMet al.Retinal thickness after vitrectomy and internal limiting membrane peeling for macular hole and epiretinal membrane.Clin Ophthalmol20126679–688
31.
TotanYGülerEGürağaçFBUzunEDoğduEBrilliant blue G assisted macular surgery: the effect of air infusion on contrast recognisability in internal limiting membrane peeling.Br J Ophthalmol201599(1)75–80
32.
OhjiMNao-INSaitoYHayashiATanoYPrevention of visual field defect after macular hole surgery by passing air used for fluid-air exchange through water.Am J Ophthalmol1999127(1)62–66
33.
WelchJCDehydration injury as a possible cause of visual field defect after pars plana vitrectomy for macular hole.Am J Ophthalmol1997124(5)698–699
34.
BriandSChalifouxETourvilleEet al.Prospective randomized trial: outcomes of SF₆ versus C₃F₈ in macular hole surgery.Can J Ophthalmol201550(2)95–100
35.
XirouTTheodossiadisPGApostolopoulosMet al.Macular hole surgery with short-acting gas and short-duration face-down positioning.Clin Ophthalmol201261107–1112
36.
TingDSCheungGCLimLSYeoIYComparison of swept source optical coherence tomography and spectral domain optical coherence tomography in polypoidal choroidal vasculopathy.Clin Experiment Ophthalmol201543(9)815–819
37.
WangJGaoXHuangWet al.Swept-source optical coherence tomography imaging of macular retinal and choroidal structures in healthy eyes.BMC Ophthalmol201515122
