Are There Any Changes in Posterior Ocular Structure Parameters in Pediatric Migraine Patients?

Abstract

Purpose

To evaluate the thickness of the peripapillary retinal nerve fiber layer (RNFL), total macula, macular ganglion cell layer (GCL), inner plexiform layer (IPL), and choroid in pediatric migraine patients and compare the values with healthy subjects.

Methods

This observational and cross-sectional study included 40 patients in the migraine group and 40 healthy control subjects. The thickness of the peripapillary RNFL, total macula, GCL, and IPL was analyzed with spectral-domain optic coherence tomography, while choroidal thickness was analyzed with the enhanced depth imaging protocol. All measurements of the migraine patients were taken in the attack-free period. Right eye selected per subject was included in the study.

Results

There was no significant difference between the 2 groups in age or sex (p>0.05). The peripapillary RNFL thickness was not significantly different between the 2 groups in any quadrant. The total macula, GCL, and IPL thickness were also not significantly different in the 9 separate macular areas defined on the basis of the Early Treatment Diabetic Retinopathy Study (p>0.05). The choroidal thickness at 5 different measurement points was not statistically significantly different between migraine patients during the attack-free period and the healthy subjects (p>0.05).

Conclusions

Childhood migraine does not cause changes in posterior ocular structure parameters.

Keywords

Choroidal thickness Macular thickness Migraine Peripapillary retinal nerve fiber layer Spectral-domain optic coherence tomography

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References

Wöber-Bingöl

Epidemiology of migraine and headache in children and adolescents.

Curr Pain Headache Rep 201317(6)341

Genizi

Khourieh Matar

Zelnik

Schertz

Srugo

Frequency of pediatric migraine with aura in a clinic-based sample.

Headache 201656(1)113–117

Kóbor

Nyári

Benedek

Túri

Age-related prevalence and features of migraine headache in Hungarian schoolchildren and adolescents.

Eur J Paediatr Neurol 201317(6)600–607

Asghar

Hansen

Amin

et al.

Evidence for a vascular factor in migraine.

Ann Neurol 201169(4)635–645

Kara

Erdemoğlu

Karadeniz

Altinok

Color Doppler sonography of orbital and vertebral arteries in migraineurs without aura.

J Clin Ultrasound 200331(6)308–314

Martinez

Proupim

Sanchez

Retinal nerve fibre layer thickness measurements using optical coherence tomography in migraine patients.

Br J Ophthalmol 200892(8)1069–1075

Dadaci

Doganay

Oncel Acir

Aydin

Borazan

Enhanced depth imaging optical coherence tomography of the choroid in migraine patients: implications for the association of migraine and glaucoma.

Br J Ophthalmol 201498(7)972–975

Demircan

Ataş

Arık Yüksel

et al.

The impact of migraine on posterior ocular structures.

J Ophthalmol 2015 2015 868967

Yülek

Dirik

Eren

et al.

Macula and retinal nerve fiber layer in migraine patients: analysis by spectral domain optic coherence tomography.

Semin Ophthalmol 201530(2)124–128

10.

Feng

Guo

Huang

et al.

Retinal nerve fiber layer thickness changes in migraine: a meta-analysis of case-control studies.

Curr Eye Res 201641814–822 Epub ahead of print.

11.

Karalezli

Simsek

Celik

Eroglu

Evaluation of choroidal thickness using spectral-domain optical coherence tomography in migraine patients during acute migraine attacks: a comparative study.

Eye (Lond) 201428(12)1477–1481

12.

Karaca

Koçer

Özdek

Akçam

Ercan

Choroidal thickness measurements in migraine patients during attack-free period.

Neurol Sci 201637(1)81–88

13.

Karalezli

Celik

Koktekir

Kucukerdonmez

Evaluation of choroidal thickness using spectral-domain optical coherence tomography in patients with migraine: a comparative study.

Eur J Ophthalmol 201525(4)338–342

14.

Mikelberg

Drance

Schulzer

Yidegiligne

Weis

The normal human optic nerve.

Axon count and axon diameter distribution. Ophthalmology 198996(9)1325–1328

15.

Jonas

Müller-Bergh

Schlötzer-Schrehardt

Naumann

Histomorphometry of the human optic nerve.

Invest Ophthalmol Vis Sci 199031(4)736–744

16.

Eriksson

Alm

Macular thickness decreases with age in normal eyes: a study on the macular thickness map protocol in the Stratus OCT.

Br J Ophthalmol 200993(11)1448–1452

17.

Demirkaya

van Dijk

van Schuppen

et al.

Effect of age on individual retinal layer thickness in normal eyes as measured with spectral-domain optical coherence tomography.

Invest Ophthalmol Vis Sci 201354(7)4934–4940

18.

Huang

Swanson

Lin

et al.

Optical coherence tomography.

Science 1991254(5035)1178–1181

19.

Headache Classification Committee of the International Headache Society (IHS).

“The International Classification of Headache Disorders, 3rd edition (beta version)” Cephalgia 201333 629–808

20.

Hershey

Powers

Vockell

LeCates

Segers

Kabbouche

Development of a patient-based grading scale for PedMIDAS.

Cephalalgia 200424(10)844–849

21.

Tan

Ouyang

Ruiz

Sadda

Diurnal variation of choroidal thickness in normal, healthy subjects measured by spectral domain optical coherence tomography.

Invest Ophthalmol Vis Sci 201253(1)261–266

22.

Bidaut-Garnier

Schwartz

Puyraveau

Montard

Delbosc

Saleh

Choroidal thickness measurement in children using optical coherence tomography.

Retina 201434(4)768–774

23.

Solomon

Grosberg

Friedman

Lipton

Retinal migraine.

J Neuroophthalmol 200727(3)243–244 author reply 244-245.

24.

Zhang

Levy

Kainz

Noseda

Jakubowski

Burstein

Activation of central trigeminovascular neurons by cortical spreading depression.

Ann Neurol 201169(5)855–865

25.

Dervisogullari

Totan

Gençler

Choroid thickness and ocular pulse amplitude in migraine during attack.

Eye (Lond) 201529(3)371–375

26.

Neuhuber

Schrödl

Autonomic control of the eye and the iris.

Auton Neurosci 2011165(1)67–79

27.

Karalezli

Simsek

Celik

Eroglu

Evaluation of choroidal thickness using spectral-domain optical coherence tomography in migraine patients during acute migraine attacks: a comparative study.

Eye (Lond) 201428(12)1477–1481

28.

Karalezli

Celik

Koktekir

Kucukerdonmez

Evaluation of choroidal thickness using spectral-domain optical coherence tomography in patients with migraine: a comparative study.

Eur J Ophthalmol 201525(4)338–342

29.

Alasil

Wang

Keane

et al.

Analysis of normal retinal nerve fiber layer thickness by age, sex, and race using spectral domain optical coherence tomography.

J Glaucoma 201322(7)532–541

30.

Bendschneider

Tornow

Horn

et al.

Retinal nerve fiber layer thickness in normals measured by spectral domain OCT.

J Glaucoma 201019(7)475–482

31.

Osborne

Melena

Chidlow

Wood

A hypothesis to explain ganglion cell death caused by vascular insults at the optic nerve head: possible implication for the treatment of glaucoma.

Br J Ophthalmol 200185(10)1252–1259

32.

Leung

Wang

Rochtchina

et al.

Relationships between age, blood pressure, and retinal vessel diameters in an older population.

Invest Ophthalmol Vis Sci 200344(7)2900–2904

33.

Ehrlich

Kheradiya

Winston

Moore

Wirostko

Harris

Age-related ocular vascular changes.

Graefes Arch Clin Exp Ophthalmol 2009247(5)583–591

34.

Wong

Klein

Tielsch

Hubbard

Nieto

Retinal microvascular abnormalities and their relationship with hypertension, cardiovascular disease, and mortality.

Surv Ophthalmol 200146(1)59–80

35.

Alamouti

Funk

Retinal thickness decreases with age: an OCT study.

Br J Ophthalmol 200387(7)899–901

36.

Hirasawa

Tomidokoro

Araie

et al.

Peripapillary retinal nerve fiber layer thickness determined by spectral-domain optical coherence tomography in ophthalmologically normal eyes.

Arch Ophthalmol 2010128(11)1420–1426

37.

Ooto

Hangai

Tomidokoro

et al.

Effects of age, sex, and axial length on the three-dimensional profile of normal macular layer structures.

Invest Ophthalmol Vis Sci 20115212 8769–8779

38.

Neuville

Bronson-Castain

Bearse

Jr et al.

OCT reveals regional differences in macular thickness with age.

Optom Vis Sci 200986(7)E810–E816

39.

Tuncer

Karahan

Zengin

Atalay

Polat

Choroidal thickness in relation to sex, age, refractive error, and axial length in healthy Turkish subjects.

Int Ophthalmol 201535(3)403–410

40.

Barteselli

Chhablani

El-Emam

et al.

Choroidal volume variations with age, axial length, and sex in healthy subjects: a three-dimensional analysis.

Ophthalmology 201211912 2572–2578

41.

Ramrattan

van der Schaft

Mooy

de Bruijn

Mulder

de Jong

Morphometric analysis of Bruchs membrane, the choriocapillaris, and the choroid in aging.

Invest Ophthalmol Vis Sci 199435(6)2857–2864

42.

Read

Collins

Vincent

Alonso-Caneiro

Macular retinal layer thickness in childhood.

Retina 201535(6)1223–1233

43.

Turk

Ceylan

Arici

et al.

Evaluation of the nerve fiber layer and macula in the eyes of healthy children using spectral-domain optical coherence tomography.

Am J Ophthalmol 2012153(3)552–559e1

44.

Yanni

Wang

Cheng

et al.

Normative reference ranges for the retinal nerve fiber layer, macula, and retinal layer thicknesses in children.

Am J Ophthalmol 2013155(2)354–360e1

45.

Barrio-Barrio

Noval

Galdós

et al.

Multicenter Spanish study of spectral-domain optical coherence tomography in normal children.

Acta Ophthalmol 201391(1)e56–e63

46.

Huynh

Wang

Rochtchina

Mitchell

Peripapillary retinal nerve fiber layer thickness in a population of 6-year-old children: findings by optical coherence tomography.

Ophthalmology 2006113(9)1583–1592

47.

Nagai-Kusuhara

Nakamura

Fujioka

Tatsumi

Negi

Association of retinal nerve fibre layer thickness measured by confocal scanning laser ophthalmoscopy and optical coherence tomography with disc size and axial length.

Br J Ophthalmol 200892(2)186–190

48.

Samarawickrama

Wang

Huynh

Burlutsky

Stapleton

Mitchell

Effects of refraction and axial length on childhood optic disk parameters measured by optical coherence tomography.

Am J Ophthalmol 2007144(3)459–461