Abstract
Purpose
Rotary Blood Pump (RBP) pulsatile strategies relative to the native cardiac cycle have been widely studied because of their benefits to hemodynamics. However, the effects that inducing pulses has on the blood compatibility of ventricular assist device (VAD) support have not yet been understood. Inflow cannulae have been found to be associated with thrombosis under conventional constant speed support of RBPs. To prevent further risks to blood compatibility, it is necessary to understand the relationship between cannula tip design and the induced pulsatility. The purpose of this study was to evaluate the flow field of 5 different tip geometries under RBP pulsatile support using stereo-particle image velocimetry (PIV).
Methods
Inflow cannulae with conventional tip geometries (blunt, blunt with 4 side ports, beveled with 3 side ports, and cage) and a custom designed crown tip were studied. All cannulae were interposed between a mixed-flow RBP and a silicone left ventricle. The contractile function and hemodynamics were reproduced in a mock circulation loop (MCL). The RBP was configured to induce synchronous and counter-synchronous pulses relative to cardiac cycles while supporting the failing ventricle.
Results
Between both pulsing strategies, low shear volume (
Conclusions
Although the clinical relationship cannot be inferred from this measurement, when considering the inflow tips only, a necessary trade-off should be made between adverse effects on blood compatibility and benefits for hemodynamics during RBP pulsatile mode.
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