Summary points

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Recent reports suggest that almost half of the UK population is expected to be obese by 2030. A number of associations between obesity and chronic pain have been displayed in previous studies, and therefore it can be expected that the presentation of obese patients with chronic pain will rise in accordance with the prevalence of obesity. No single causative relationship between the two can be suggested, so the link between them is believed to be multifactorial. Despite this, little work has been done to draw together the many associations between obesity and pain. A better understanding of their connection, then, is required to appropriately manage this patient group that is increasing in numbers. This article aims to draw together existing evidence on the associations between obesity and pain to create a model of their multifactorial relationship. The article will systematically address each of the current theories in order to gradually build a diagrammatic representation of the relationship, which shall conclude the article.

26:T41c,

Adequate pain control is still a significant challenge and largely unmet medical need in the 21st century. With many small molecules failing to reach required levels of potency and selectivity, drug discovery is once again turning to nature to replenish pain therapeutic pipelines. Venomous animals are frequently stereotyped as inflictors of pain and distress and have historically been vilified by mankind. Yet, ironically, the very venoms that cause pain when directly injected by the host animal may actually turn out to contain the next generation of analgesics when injected by the clinician. The last 12 months have seen dramatic discoveries of analgesic tools within venoms. Spiders, snakes and even centipedes are yielding peptides with immense therapeutic potential. Significant advances are also taking place in delivery methods that can improve bioavailability and pharmacokinetics of these exciting natural resources. Turning proteinaceous venom into pharmaceutical liquid gold is the goal of venomics and the focus of this article.

27:T48b,Summary points

• Individual variability in pain perception and differences in the efficacy of analgesic drugs are complex phenomena and are partly genetically predetermined.

• Analgesics act in various ways on the peripheral and central pain pathways and are regarded as one of the most valuable but equally dangerous groups of medications.

• While pharmacokinetic properties of drugs, metabolism in particular, have been scrutinised by genotype–phenotype correlation studies, the clinical significance of inherited variants in genes