Clinical Pediatrics

Three lots of Lirutrin (measles-mumps-rubella live, attenuated virus vaccine) were evaluated in a double-blind, placebo-controlled clinical study involving 273 children. The vaccine consisted of a combination of Schwarz strain measles, Jeryl Lynn strain mumps, and Cendehill strain rubella vaccine viruses. The frequency of positive clinical findings was essentially the same in susceptible vaccinees, immune vaccinees, and placebo recipi ents ; indicating that the observed symptoms were not caused by the vaccine. Antibody assay of paired serum samples revealed that measles, mumps, and rubella seroconversion rates in triple susceptible vaccinees were excellent, ranging from 96 to 98 per cent with all three lots com bined. Results of this study show that Lirutrin trivalent vaccine is well tolerated and highly effective.

This report evaluates the effectiveness of cephalexin in the treatment of bacteriuria in 93 children. Cephalexin therapy eradicated sensitive organisms in 97 per cent of the cases regardless of recurrence, structural abnormality, or status of renal function. Nevertheless, recurrences with a new, resistant organism occurred significantly in certain patients, especially those with major anatomic abnormalities, during a six-week follow-up period. The incidence of drug reac tions was low.