
Editorial
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These medication errors have occurred in health care facilities at least once. They will happen again—perhaps where you work. Through education and alertness of personnel and procedural safeguards, they can be avoided. You should consider publishing accounts of errors in your newsletters and/or presenting them in your inservice training programs.
Your assistance is required to continue this feature. The reports described here were received through the USP Medication Errors Reporting Program (MERP), which is presented in cooperation with the Institute for Safe Medication Practices (ISMP). If you have encountered medication errors and would like to report them, you may call USP toll-free, 24 hours a day, at 800-233-7767 (800-23-ERROR).
Any reports published by ISMP will be anonymous. Comments are also invited; the writers' names will be published if desired. ISMP may be contacted at the address shown below.
Errors, close calls, or hazardous conditions may be reported through the ISMP (www.ismp.org) or United States Pharmacopeia (USP) (www.usp.org) Web sites or communicated directly to ISMP by calling 800-FAIL-SAFE or via e-mail at
The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), discuss methods of prevention, and promote reporting of ADRs to the Food and Drug Administration's (FDA) medWatch program (800-FDA-1088). If you have reported an interesting preventable ADR to medWatch, please consider sharing the account with our readers.
This continuing feature will update readers on recent developments in cardiovascular pharmacotherapy. Cardiovascular disease remains the number one killer in the United States and more clinical outcome trials have been conducted in cardiology than in any other field of medicine. Given this rapidly expanding knowledge base, pharmacists can have a significant impact on prevention and treatment—if they keep current with developments in drug therapy.
The increasing complexity of cancer chemotherapy now requires that pharmacists be familiar with these highly toxic agents. This column will review various issues related to preparation, dispensing, and administration of cancer chemotherapy, and review various agents, both commercially available and investigational, used to treat malignant diseases.
Multiple studies have found an association between the prompt initiation of empirically-appropriate antimicrobial therapy and improved patient outcomes. Such empiric-antimicrobial therapy is often broad; however, once the patient's infectious syndrome, microbiology, and susceptibilities are more defined, it is important to refine antimicrobial therapy. Despite the potential benefits of an “antimicrobial de-escalation” approach, it may be difficult to enforce in clinical practice. Mayo Clinic's Computer-Based Antimicrobial Monitoring System (CBAM) is a medical-informatics tool that was used to assist in this endeavor. This study evaluates the hypothesis that CBAM can enhance the de-escalation of vancomycin and broad-spectrum combination antimicrobial therapy.
Hospitalized patients at the Mayo Clinic were screened from January through June 2006 using rule-based algorithms incorporated by CBAM. Interventions were performed by physicians and pharmacists as pertinent. These patients were compared with a historical group of patients obtained by CBAM reporting capabilities. De-escalation rates and mean duration of antimicrobial therapy were compared between groups.
Vancomycin de-escalation rates significantly improved from 33% to 68% with intervention (
Utilizing the Mayo Clinic's CBAM system to identify potential patients for de-escalation is a unique approach and was successful at improving adherence to vancomycin de-escalation.
To describe a case of calcium channel blocker overdose along with an angiotensin-converting enzyme inhibitor and angiotensin receptor blocker, which was successfully treated with high-dose insulin with dextrose and potassium supplementation (HDIDK).
A 52-year-old woman was transferred to an admitting hospital after ingesting 14 tablets of trandolapril/verapamil SR (
The non-dihydropyridine, verapamil, causes dilation of the coronary and peripheral vasculature by inhibiting the influx of calcium ions through L-type calcium channels. HDIDK is thought to be a useful treatment in the state of hypoinsulinemia, which prevents the uptake of glucose by myocytes and can lead to decreased inotropy and eventually shock. High-dose insulin allows glucose to be properly used for energy by the myocytes.
Currently HDIDK therapy is recommended as an adjunct to conventional therapy in calcium channel blocker poisoning only after fluids, high-dose calcium salts, and vasopressors. In this case, early implementation of HDIDK treatment was shown to shorten the length of therapy.
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This monthly feature will help readers keep current on new drugs, indications, dosage forms, and safety-related changes in labeling or use. Efforts have been made to ensure the accuracy of the information; however, if there are any questions, let us know at
Over the course of its evolution, the personal digital assistant (PDA) has grown from a predominantly offline, referential tool that had to be synchronized to a personal computer for updates to one that is integrated with a cell phone and subsequently yields high-speed global connectivity. This integration provides pharmacists with mobile access to virtually any available information from anywhere. Early uses of smartphones for Internet access were often frustrating due to slow speeds and poor reliability. The end user's experience with cellular broadband has changed dramatically over the last few years. What follows is an exploration of the technology and capabilities underlying PDA and smartphone connectivity.
The Director's Forum series is written and edited by Michael Sanborn and Robert Weber and is designed to guide pharmacy leaders in establishing patient-centered services in hospitals and health systems. Another specific goal of this column is to address many of the key challenges that pharmacy directors currently face, while providing information to foster growth in pharmacy leadership and patient safety. This
Hospital Pharmacy presents this feature to keep pharmacists abreast of new publications in the medical/pharmacy literature. Articles of interest will be abstracted monthly regarding a broad scope of topics