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Quality improvement (QI) activities emphasize systems to prevent or detect inevitable errors by fallible humans. Aside from intentional misconduct or impaired judgment, human errors often are attributed to system factors, deemphasizing the role of individual decision making as a potential cause of error. Convincing data show that cognitive and motivational biases affect how providers collect and apply clinical data. Our purpose is to increase audience awareness of cognitive “traps” in medical decision making. We will discuss illustrative case studies, practical ways to incorporate these concepts into QI and patient safety activities, and uses of “debiasing” and other strategies to improve individual decision making.
(1) Describe the importance of individual cognitive processes in medical decision making and error and situations in which these processes might be either beneficial or harmful. (2) Describe cognitive processes, heuristics, and biases that play a role in otolaryngologists’ medical and surgical decision making and how these factors may contribute to medical error. (3) Implement individual and institutional methods to identify and mitigate these factors to improve personal clinical performance.
On the hinge of health care reform, the Board of Governors’ (BOG’s) 2014 hot topic is: will fee for service survive? Expert panelists, consisting of American Academy of Otolaryngology—Head and Neck Surgery presidents, BOG chairs, and physician payment and policy workgroup members, will discuss if fee for service will be superseded by payments based on work relative value units, quality measures, hospital employment, and bundled payments. Presentations will be made on current and past payment structures, bundled payments, quality metrics, and the sustainability of private practice. Time for interaction between the audience and panelists will be ensured through a final round table discussion.
(1) Describe the history of fee for service and how it has changed in the past 10 years. (2) Relate the impact of health care reform on current and future payment systems. (3) Recognize the challenges private practice will have with new reimbursement models.
One of the biggest transitions the healthcare industry has historically ever experienced is around the corner with the ICD-10 implementation deadline less than one week away. As many physician practices finish up last steps for preparation it is important to anticipate errors that may result in delayed payment. This miniseminar focuses on potential problems and the preemptive plans to have in place with your payers along with reactive steps you should take as a provider to quickly resolve these issues and keep your practice running. Learn about practices that have experience with the best ways to handle reimbursement delays.
(1) Understand how the proper steps can lessen impact of implementation to ICD-10 on your practice. (2) Learn about steps that payers are taking to facilitate communication with providers to avoid issues that they are anticipating providers may experience with the transition. (3) Learn about key resources offered through the Academy, the physician community, and from private payers to help you with transition to ICD-10.
The landscape of physician payment is changing, with quality and measures becoming more intertwined with how payment is and will be provided for services. This miniseminar will outline the efforts of our Academy, specifically the Physician Payment Policy Workgroup (3P) and the Ad Hoc Payment Model Workgroup, to prepare members for the implementation of the Affordable Care Act, so that otolaryngologists have the tools to participate in diverse payment systems. Topics include new public and private payment models including bundling and the importance of measures in the future of quality and payment initiatives.
(1) Discuss payment models as they relate to health care reform initiatives, new payment models, and Academy efforts to prepare members for changes in reimbursement. (2) Describe how existing measure sets (adult sinusitis and acute otitis externa) were developed for otolaryngology, tracking, and reporting and how these measures affect reimbursement. (3) Recognize the Academy’s efforts to interact and collaborate with public and private payers related to alternative payment model options and opportunities for otolaryngologists.
Patient satisfaction is an emerging theme in modern health care, and there are myriad federal-, state-, institutional-, and practice-level initiatives that emphasize systematic measurement and public reporting of patient satisfaction scores. Moreover, patient satisfaction scores are increasingly weighted in reimbursement formulas and pay-for-performance initiatives. This course will introduce the significance of patient satisfaction in otolaryngology, review nuts and bolts of patient satisfaction measurement and reporting, and offer effective and simple techniques for providers to better communicate with patients and improve satisfaction scores, even within the time constraints of modern practice.
(1) Recognize patient satisfaction as a quality indicator and learn initiatives surrounding measurement, reporting, and benchmarking of patient satisfaction scores. (2) Explain how patient satisfaction scores affect the bottom line (correlate with productivity, market share, and reimbursement. (3) Practice techniques for communication with patients that will result in greater patient engagement and increased satisfaction scores.
This miniseminar addresses a common knowledge gap regarding the purpose and process of maintenance of certification (MOC) in our field. Expert panelists include representatives from the American Board of Otolaryngology and the American Academy of Otolaryngology—Head and Neck Surgery (AAO-HNS) Education Council. Attendees will understand MOC as a 4-component, lifelong learning and quality improvement program. We will address concerns, anxieties, and misconceptions of part III MOC; 2 panelists who have recently taken and passed the part III examination (1 academic and 1 private practice) will describe their experiences and recommendations. Finally, we will share AAO-HNS educational resources designed for lifelong learning and MOC preparation.
(1) Recognize MOC as a lifelong learning and quality improvement program. (2) Understand the 10-year cycle and the specific requirements for each of the 4 components of MOC. (3) List AAO-HNS educational resources designed for lifelong learning, maintenance of certification, and recertification.
There are many questions about the role of otolaryngologists in an Affordable Care Organization (ACO). Our team of experts from private practice to academia, from administration to technology, will engage the audience. We will incorporate content that focuses on patient care, quality improvement, and access. We will welcome questions and advice from the audience.
(1) Make an informed decision whether to join or not to join an ACO. (2) Recognize the pros and cons to such a decision. (3) Manage the risk involved in this decision.
Unprecedented availability of health-related information on the Internet, television, radio, and print has empowered our patients to play larger roles in medical decision making. Increasingly, to help educate a knowledge-hungry public and to help build their practices, otolaryngologists must interact with journalists. Formal media training is often lacking in residency or fellowship, making this task seem daunting. This miniseminar reveals the multitude of media opportunities, including those on the Academy Web site, and how to best interact with journalists and the public. Speakers include renowned television and print health journalists and otolaryngologists with media experience. Audience participation is encouraged.
(1) Improve their communication with journalists. (2) Recognize the opportunities within and outside the Academy for print, television, radio, and online media exposure. (3) Increase involvement with the media to enhance your practice and educate your patients.
Physicians must confront significant financial issues over the course of their careers. These issues can be especially problematic for young physicians entering practice, although decisions around professional and personal finance must be made throughout one’s career. Matters such as professional liability, asset protection, practice management, employment contracting, and retirement planning all must be addressed proactively and confidently for maximal financial benefit. This miniseminar will include presentations from physicians and financial professionals that highlight these important decisions and considerations for otolaryngologists. Representatives of Academy committees will participate in an interactive discussion around central topics of vital interest to practicing physicians.
(1) Recognize the importance of building and protecting their practices. (2) Preserve their investment in their futures. (3) Examine employment contracts and retirement planning.
Concussions and return to play are public health concerns that are gaining coverage as incidence and public awareness increases. Otolaryngologists play an increasing role in the diagnosis of facial trauma and concussions. Not only does the public and health community look to head and neck surgeons for facial trauma treatment, but there is also increasing need for otolaryngologists to play a role in helping concussed athletes return to play. This miniseminar will present the relationship of facial trauma to concussions, review guidelines for diagnosing concussions, review guidelines for returning athletes to play, and review how otolaryngologists fit into the treatment algorithm.
(1) Consider the relationship between facial trauma and concussions. (2) Cite the criteria for diagnosing concussions and returning athletes back to play. (3) Determine the role the otolaryngologist plays in helping the athlete return to play.
The miniseminar will address regional reconstruction of the head and neck, with attention to surgical options available to the general otolaryngologist–head and neck surgeon. The format will include a descriptive portion of both longstanding and emerging reconstructive flap options that are commonly used today. The remainder will be case based, with depiction of commonly encountered wounds or defects followed by an interactive forum to discuss surgical and/or medical strategies for wound management. Audience participation will be encouraged through the Audience Response System to discuss preferred surgical strategies.
(1) Describe recent advances of commonly used regional flaps for head and neck reconstruction: pectoralis, submental, supraclavicular flaps, temporoparietal, facial artery mucosal muscle, and trapezius. (2) Cite the indications and contraindications for each flap, with consideration of location and size of defect, mobility, and prior irradiation. (3) Incorporate the information provided to develop an algorithmic approach to wound management using regional flaps with awareness of their use and limitations.
Otolaryngologists are frequently faced with the challenges of managing patients who have sustained significant injuries due to maxillofacial trauma. Often, these are associated with injuries to other organ systems that may preclude timely attention to the maxillofacial injuries. Sometimes, patients present for medical care after some delay. It is important for surgeons to be able to decide when it is reasonable to delay intervention and when delay is mandatory, as well as have an understanding of how surgical intervention may change as a result of such delays. This miniseminar will address these issues.
(1) Explain the indications for delayed management of maxillofacial injuries. (2) Recognize typical contraindications to early intervention for the management of maxillofacial injuries. (3) Use techniques for delayed intervention and management of maxillofacial injuries and how they differ from acute interventions.
This 3-hour course sponsored by the American Academy of Otolaryngology—Head and Neck Surgery Foundation Facial Plastic and Reconstructive Surgery Education Committee will provide a concise review of facial plastic surgery topics that will provide attendees a starting point in preparing for the recertification examination (maintenance of certification [MOC] part III). Faculty will use a combination of didactic and case-based formats to cover essential content areas including facial trauma, aging face, facial defect repair, and surgical management of chronic facial paralysis. The course will also fulfill the MOC part II requirements by providing continuing medical education credit.
(1) Demonstrate increased understanding of key topics in facial plastic surgery. (2) Guide further study on these topics in facial plastic surgery. (3) Access available resources in facial plastic surgery that will assist in test preparation.
Four experienced rhinoplasty surgeons divulge their 3 techniques that prove useful in almost every case. Every component of rhinoplasty will be covered systematically with tips being offered on the straight dorsum, functional middle vault, and the refined tip. Videos or step-by-step photographs will enable attendees to quickly grasp how and when to use these maneuvers to consistently improve their patient outcomes. Topics to be covered include grafts in rhinoplasty made easy, management of the lateral crus, ultrasonic sculpting of the dorsum, suture fixation techniques revisited, and critical closing steps.
(1) Employ suture techniques such as medial crural fixation stitch and upper lateral cartilage suspension sutures to maintain tip projection and middle vault competency, respectively. (2) Select cartilage grafts that camouflage defects, reinforce projection, and maintain the nasal airway. (3) Choose appropriate tip refinement techniques to consistently improve patient outcomes.
This course is sponsored by the American Academy of Otolaryngology—Head and Neck Surgery CORE Grants program and is designed to provide a practical, “nuts and bolts” guide to incorporating research into your otolaryngology practice. A diverse group of experienced surgeon-scientists will cover all of the relevant topics from how to choose a project, get funding, publish your work, patent your ideas, and more. Whether you are looking to begin a small clinical study or embark on a career in research, this miniseminar will provide you with the tools to avoid common pitfalls and make your research a successful and rewarding experience.
(1) Design a rewarding research project based on your interests, resources, and time. (2) Market your research idea in order to get funding and successfully publish your findings. (3) Determine when and if you should patent your ideas and how to work with industry to bring your research into the clinic.
The academic bowl has been an annual interactive resident competition at the American Academy of Otolaryngology—Head and Neck Surgery Foundation annual meeting for the past 8 years. Four teams from across the country are selected based on strict academic criteria. These programs send 3 residents to represent them in an interactive question-and-answer format. The educational committees of the foundation develop questions. They are presented to the teams and the audience. Each team responds, and the audience is given a chance to pit their knowledge against the residents’. The resident team with the best score at the end of the competition wins a prize.
(1) Attendees will be able to see what the current level of knowledge is in various subspecialties of otolaryngology. (2) Attendees will be able to compare their knowledge base to residents across a wide range of topics. (3) Attendees will be able to determine areas of weakness in their knowledge base as compared with residents.
Patients with facial nerve paralysis suffer significant cosmetic and functional morbidity. Most of these patients eventually require the attention of the facial plastic reconstructive surgeon. Management of the eye involves both loading the upper eyelid and tightening the lower eyelid. Mid-face reconstruction can be addressed by either dynamic sling using a temporalis muscle or adynamic with acellular suspension. The advantages and risks associated with the procedures and the operative results of these techniques will be discussed by the panel. Each panelist will present their preferred method of rehabilitation with case scenarios to explore subtleties of each surgical approach.
(1) Upon completion of this session, the attendee will be able to determine the management of the upper and lower eyelid complex. (2) Attendees will be able to discuss the differences in dynamic and adynamic reconstruction of the lower face. (3) Attendees will be able to manage the nasal airway in patients with facial nerve paralysis.
How does a surgeon decide to optimize the outcome after performing a salvage laryngectomy? The goal of this miniseminar is to help the surgeon understand the decision-making process for the reconstruction of the hypopharynx after salvage laryngectomy using evidence from 2 large national retrospective reviews. In addition, the role of withholding neck dissection to reduce morbidity will be discussed. Substantial time will be left at the end of the presentation to discuss specific case examples and have the faculty discuss perioperative and postoperative management.
(1) Cite the current evidence for flap-assisted closure for patients undergoing salvage laryngectomy. (2) Evaluate the risks and benefits of performing neck dissection for salvage patients. (3) Use case examples to demonstrate management relating to choice for neck dissection, use of the salivary bypass tube, and choice of flap-assisted reconstruction.
Our expertise and skill are essential, but not sufficient, for optimal patient outcomes. We work with teams and we work within systems with variable functionality. How can we make sure our team works together effectively? How can we improve the systems within which we work? An expert panel will describe how we can use simulation and the science of human factors to improve the processes, the equipment, and even the spaces in which we work. Examples address emergency response teams, airway carts, and electronic health records. Our keynote speaker, F. Jacob Seagull, PhD, is an expert in human factors applications in health care.
(1) Understand how simulation can be used to improve health care delivery systems and safety. (2) Understand how human factors principles can be applied to improve health care delivery systems and safety.
With the progressive improvements in imaging resolution of ultrasound, concurrent reduction in capital expenditure, and portability, this modality is ideally suited to point-of-care use by most otolaryngology practices. Primary and exported training courses through the American College of Surgeons have provided a clinical starting point. An accreditation process for head and neck ultrasound is now available through a joint project between the American Institute for Ultrasound in Medicine and the Academy. This miniseminar presents the practical application of ultrasound to general, pediatric, endocrinologic, and oncologic conditions through a panel of outstanding experts from radiology and otolaryngology.
(1) Cite the principles of ultrasound and its application to conditions of the head and neck. (2) Recognize the advantages of ultrasound-guided aspiration of samples for cytology and other chemical tests. (3) Learn ultrasound techniques and eventual accreditation of skills.
Humanitarian surgical trips provide an opportunity to deliver care that would otherwise be unavailable. However, there is significant variability among humanitarian missions. This variability has contributed to some unfortunate patient outcomes. This miniseminar will explore “deadly sins” common to medical humanitarian efforts and issues that are unique to surgical humanitarian missions. Panelists with extensive humanitarian experience will discuss available data and areas with a lack of data concerning humanitarian efforts. Best practices will be discussed with respect to appropriate standard of care, duration, follow-up, research, role of the media, and integration with local care systems.
(1) Critically evaluate the existing literature and identify gaps in knowledge regarding humanitarian efforts in otolaryngology. (2) Recognize “best practices” including appropriate standard of care, duration, follow-up, conduct of research, role of the media, and integration with local care systems. (3) Critically evaluate and devise methods to improve existing humanitarian efforts in otolaryngology.
Chronic cough is an increasingly important public health concern, accounts for a large number of ambulatory care visits, and often involves a protracted clinical course. Otolaryngologists play a critical role in the care of these patients because of our interdisciplinary approach to the aerodigestive tract and our mastery of many procedures used to evaluate and treat related conditions. This miniseminar will present challenging cases with panel discussion and audience participation to emphasize evidence-based practice and the “state-of-the-art” for patients with chronic cough. Controversial areas will include prioritization, the use of evidence-based protocols, and the importance of early diagnosis in value-based health care.
(1) Describe evidence-based treatment guidelines in the evaluation and treatment of chronic cough. (2) Use the spectrum of common and uncommon causes of chronic cough with an appreciation of the underlying physiology. (3) Evaluate these complex patients, perform objective testing when indicated, and prescribe appropriate pharmacotherapy for patients with chronic cough.
This miniseminar will provide a multidisciplinary perspective (rhinology, neurotology, head and neck, and neurosurgery) on the pathophysiology and management of cerebrospinal fluid disorders encountered by the practicing otolaryngologist. The program will discuss epidemiologic, radiologic, medical, and surgical aspects of spontaneous and iatrogenic cerebrospinal fluid leaks of the anterior and lateral skull bases and will highlight important considerations in proper diagnosis, workup, and management.
(1) Properly recognize, diagnose, and manage spontaneous and iatrogenic cerebrospinal fluid (CSF) leaks of both the anterior and lateral skull base. (2) Explain various medical and surgical interventions available for the treatment of CSF disorders encountered by the otolaryngologist.
This international symposium will focus on the Academy’s international relations and activities in a variety of key regions around the globe. President Richard W. Waguespack, MD, will welcome the audience, and president-elect Gayle Woodson, MD, will describe her vision for enhanced international collaboration. The American Academy of Otolaryngology—Head and Neck Surgery Foundation Regional Advisors for the Europe, Middle East, Pacific Rim, and Turkey/Greece/the Balkans will introduce eminent speakers to describe the state of otolaryngology in these regions and subject areas, including socioeconomic and workforce issues.
(1) Understand the myriad ways the Academy interacts with otolaryngology communities in different regions. (2) Appreciate the opportunities for collaboration in scientific exchange, research, fellowships, and observerships. (3) Learn the Academy’s resources available to members, subscribers, meeting attendees, and Web visitors.
This miniseminar is designed to update general otolaryngologists on cutting-edge advances. Dr Nussenbaum will present on human papillomavirus (HPV)–related oropharyngeal cancer, now widely accepted to be a distinct disease. With the increasing incidence of HPV, otolaryngologists need to be familiar with underlying principles that direct comprehensive evaluation and management. Dr Hwang will review the evidence for various methods of drug delivery in treating chronic rhinosinusitis and how the efficacy of topical medical therapy directly relates to the modality of delivery. Dr Wilkinson will give a comprehensive overview of the critical considerations in assessment, diagnosis, and treatment of sudden sensorineural hearing loss.
(1) List current recommendations for diagnosis and management of sudden sensorineural hearing loss. (2) Incorporate into practice with up-to-date clinically relevant information about screening, prevention, diagnosis, and management of HPV-related oropharyngeal cancer. (3) Consider the range of options for topical drug delivery to the paranasal sinuses and the evidence substantiating their use.
Despite adoption of checklists and timeouts in many operating rooms across the country, surgical errors continue to happen. Our program will address some of the myths associated with checklists, including that stand-alone error prevention strategies such as checklists prevent wrong-side surgeries or that checklists should be mandated and will prevent errors. We will then discuss how the checklist process needs to be augmented with specific surgeon-as-leader behaviors: effective team building, communication, and creating a safety focus. We will also discuss some of the challenges around developing and building these techniques and behaviors in our institutions.
(1) At the end of this session, attendee surgeons will demonstrate improved leadership skills. (2) Upon completing this session, attendee surgeons will learn the skills necessary to establish a high-functioning team.
Getting published is a practical, results-oriented miniseminar that emphasizes success strategies for residents, young physicians, and practicing clinicians. Explicit tips are offered to motivate young authors and clinicians to share experience and insights by publishing in peer-reviewed journals. Myriad viewpoints will be presented, including editor-in-chief, managing editor, resident physician, young physician, and practicing clinician. Attendees will learn why publishing is important, how it can prepare them for fellowship and clinical practice, and how it fosters critical thinking skills that lead to better patient care. Time is allowed for questions and answers.
(1) Recognize why publishing in journals is important for young physicians and practicing clinicians. (2) Use best practices associated with successful publishing in biomedical journals. (3) Avoid the top pitfalls when submitting a manuscript for publication consideration.
Otolaryngologists are familiar with the available techniques for establishing an airway. In elective procedures with an anticipated difficult airway, the surgeon, anesthetist, and other members of the team may establish a clear plan of action in the controlled setting of the operating room. Upper airway obstruction may present as a life-threatening emergency in which quick action is essential and discussion time is limited. Some of these cases are extraordinarily challenging. In this miniseminar, we present the options available for establishing an airway through cases in which “standard” plans of action required modification to achieve a successful outcome.
(1) Recognize what makes an airway “difficult.” (2) Weigh the options available for establishing a precarious airway. (3) Establish a decision-making process through case presentations.
The Scary Cases 2014 miniseminar uses a case-base, interactive approach to providing education in patient care and risk management. Exceptionally scary cases presented by well-known experts and community-based clinicians will focus on what could or has gone wrong in the management of otolaryngology patients. Each expert will present a specific case that was difficult to manage, had unexpected morbidity, or resulted in litigation. Attendees will participate using the Audience Response System for key decisions during the case. Difficult cases are often great sources of learning. This miniseminar will provide education on how to anticipate and avoid unwanted outcomes.
(1) Describe potential pitfalls inherent to the practice of otolaryngology that may lead to adverse outcomes or put patients at excessive risk. (2) Recognize legal principles of medical malpractice and learn ways to minimize risk of malpractice in the everyday practice of otolaryngology.
The concept of this miniseminar is to describe how otolaryngology was practiced at the turn of the past century by describing how common otolaryngological diseases were diagnosed and managed and to describe the state of surgical technology and technique
(1) Gain perspective on the antecedents of today’s practice of otolaryngology. (2) Recognize the long tradition in otolaryngology of adapting new ideas and introducing technological innovations.
Seeking an edge in the competitive grant world? This interactive miniseminar will provide a comprehensive review of key elements to a fundable grant. Practical tips on scientific writing, building a productive research team, and maximizing resources will be provided. An overview of basic statistics will help to maximize collaborative efforts with your statistician. Gain insight into the scoring process from an experienced National Institutes of Health reviewer who will highlight common pitfalls. Current 2014 funding mechanisms will also be provided. Residents and faculty new to the grant process, as well as researchers striving to improve their score, will benefit from this course.
(1) Explain key components of a grant to include hypothesis, specific aims, timeline, statistics, budget, and institutional review board. (2) Describe the scoring mechanism, review process, and common pitfalls leading to an unfundable grant. (3) Recognize current grant mechanisms and funding opportunities, with emphasis of American Academy of Otolaryngology—Head and Neck Surgery Foundation CORE grants, K-awards, and R-01 funding.
There are significant technological advances occurring in different otolaryngology subspecialties. In addition, there are many opportunities for cross-pollenization of ideas to envision novel ways to use these technologies. In this miniseminar, the participant will learn about novel technologies being applied in a selected number of technology-heavy areas of otolaryngology. The panel and audience will engage in an interactive discussion about the different technologies and where else these could be employed or changed to solve other clinical problems. Topics include intraoperative computed tomography advances, vascular injury and control, frontiers in robotic surgery, computer-assisted surgery, middle ear gels, 3-dimensional printing, and biomaterials.
(1) Discuss new technologies being applied in different fields within otolaryngology. (2) Review where these technologies have inherent strengths and limits in their current application. (3) Synthesize new and unique applications for these technologies in otolaryngology.
Epistaxis management is rarely discussed in comprehensive detail, and we feel this topic is grossly underrepresented at the annual meeting. Our goal is to thoroughly discuss current epistaxis treatment techniques used by a panel of experts. Each panelist will review personal experience with current advanced management techniques, emphasizing supporting data and best evidence. Modalities discussed include advanced endoscopic techniques, electrosurgical and plasma cautery, directed vessel ligation, endovascular embolization, and large vessel patching for a wide range of scenarios including anterior and posterior epistaxis as well as large vessel hemorrhage. Special considerations such as hereditary hemorrhagic telangiectasia will also be discussed.
(1) Describe the current therapies available to the otolaryngologist to treat epistaxis. (2) Recognize the strengths and weaknesses of each therapy for epistaxis. (3) Implement the various therapies for epistaxis.
Patients with thyroid and parathyroid disease are commonly encountered in a head and neck surgery practice. While the evaluation and management of many patients is relatively straightforward, others are significantly more complicated. The goal of this session is to discuss complex clinical scenarios encountered in the outpatient clinic. The cost-effective use of diagnostic testing as well as the factors critical in treatment planning will be outlined. The entities reviewed will include fine-needle aspiration for thyroid nodules, surveillance of patients with well-differentiated thyroid cancer, and evaluation and decision for surgery in hyperparathyroidism.
(1) Describe the appropriate use of fine-needle aspiration biopsy with a focus on implementing the use of molecular markers into the diagnostic evaluation. (2) Explain the indications for adjuvant radioactive iodine therapy in patients with low-, intermediate-, and high-risk well-differentiated thyroid cancer. (3) Implement a cost-effective approach to preoperative imaging in a patient with primary and recurrent hyperparathyroidism.
Sialendoscopy is recognized as a first-line option in the management of salivary stones. The role of sialendoscopy in nonstone disorders is less clear. This miniseminar focuses on the indications and applications of sialendoscopy for nonstone disorders including ductal scar and trauma, Sjogren disease, radioiodine sialadenitis, and recurrent juvenile parotitis. The moderator will present cases of nonstone disorders to a panel of experts in order to determine their use of sialendoscopy in the management of these disorders. The discussion will conclude with a brief overview of the current best evidence of the role of sialendoscopy in the management of nonstone disorders.
(1) Recognize which nonstone salivary disorders may benefit from sialendoscopy. (2) Learn techniques for applying sialendoscopy to nonstone disorders. (3) Understand the outcomes and limitations of sialendoscopy in the management of nonstone disorders.
In this presentation, the editors-in-chief of several major otolaryngology journals will provide instruction and insight on many aspects of the peer-review process, for current and future reviewers. We will address the roles of peer reviewers, associate editors, and the editorial board and address the importance of voluntary participation in the peer-review process. We will discuss several practical matters, including frequent errors made by authors and reviewers and tips and strategies for improving reviews and papers. We will discuss decisions on revision versus rejection and responding to reviewer critiques/disagreements. We will also discuss how to advance up the editorial ladder.
(1) To educate attendees on the process of peer review and on how to improve their own peer reviews and manuscript submissions. (2) To educate attendees on how editors select associate editors and editorial board members. (3) To allow attendees to learn about the review and publication process.
The myriad lesions that present in the oral cavity can stymie even the most astute otolaryngologist. These may span from the most benign, such as recurrent canker sores, to more ominous malignancies, often with very similar appearances. Furthermore, various systemic illnesses such as Sjogren disease, lichen planus, Crohn disease, lupus, and nutritional deficiencies may present with vexing oral cavity lesions. This evidence-based miniseminar supported by the American Academy of Otolaryngology—Head and Neck Surgery Head and Neck Surgery & Oncology Committee will explore the differential diagnoses, workup, and management of a spectrum of oral lesions as well as early-stage oral cavity cancer.
(1) Describe and identify some of the more unusual oral conditions that present to the otolaryngologist. (2) Identify signs and symptoms of systemic illness in the oral cavity. (3) Examine the management of premalignant oral lesions, the role for screening and biopsy, and the appropriate workup and surgical management of early oral cancer.
Endoscopic approaches to the skull base are being used with increasing frequency in tertiary care centers and in community settings. This miniseminar aims to clarify the current status of endoscopic skull base surgery. The evolving trends have led to controversies regarding the extent of endoscopic resections and utilization for malignancies. The panelists will review surgical techniques, contemporary surgical outcomes for paranasal sinus and spheno-clival cancers, disease-specific approaches, and quality of life after endoscopic surgery.
(1) Recognize the role of endoscopic surgery in the management of skull base malignancies. (2) Describe the technical aspects of expanded endonasal surgical approaches to skull base tumors. (3) Assess the impact of endoscopic surgery on quality of life for skull base tumors.
Despite increased knowledge about head and neck paragangliomas, educational gaps still exist regarding diagnosis, evaluation, and management options. This miniseminar will provide up-to-date clinically relevant information using a case-based format. Best available evidence-based medicine presentations on focused learning points and audience response will be incorporated. Basic concepts and controversial topics will include accurate disease diagnosis; tumor genetics and defining the at risk-population for familial disease; management decision making between surgery, radiation, and observation with expected tumor-control outcomes; identification of patients at particular risk for treatment-related complications; and rehabilitation options to maximize functional outcomes.
(1) Describe the current “state-of-the-art” for evaluation and management of head and neck paragangliomas. (2) Discuss the considerations that affect how treatment decisions are made. (3) Use methods for minimizing complications while maximizing tumor-control and functional outcomes.
Human papillomavirus (HPV)–related oropharyngeal cancer is now recognized as a clinically distinct entity, and data describing the nature of the epidemic, optimal treatment strategies, and survival outcomes are rapidly developing. Our patients are asking pertinent questions about HPV transmission, the role of vaccination, and monitoring recommendations. This miniseminar will update practitioners on the accuracy of testing, how to counsel patients and families regarding the nature of HPV infection (risk and transmissibility), vaccination, the management of benign lesions, and surveillance. This panel will appeal broadly to trainees, general otolaryngologists, and head and neck surgical oncologists.
(1) Advise patients and partners regarding HPV infection and transmission. (2) List the Centers for Disease Control and Prevention recommendations for HPV vaccination. (3) Develop a surveillance plan for patients with HPV and their families.
Transoral robotic surgery (TORS) has become a popular approach for management of oropharyngeal carcinoma. The miniseminar will be organized as a tumor board panel staffed with a head and neck surgeon, radiation oncologist, medical oncologist, and pathologist. Two cases will be presented to highlight 3 controversial topics: (1) What are acceptable surgical margins and does human papillomavirus (HPV) status affect margin status? (2) Following TORS with negative margins, does the primary site require radiotherapy and does HPV status affect that decision? (3) How do “poor prognostic factors” affect decisions regarding adjuvant therapy, radiation dose, and treatment fields?
(1) Differentiate the pathologic characters of HPV-positive and HPV-negative tumors and demonstrate how this finding affects treatment margins. (2) Explain the indication for treating the primary site after TORS resection. (3) Recognize impact of poor prognostic factors of adjuvant therapy decisions, including treatment dose.
Sialendoscopy is a relatively new addition to otolaryngology. It offers the opportunity to work with salivary gland disease with noninvasive procedures that yield potentially superior outcomes to previous techniques. It is exciting but very challenging. This miniseminar is geared toward the beginner. It will give basic techniques and point out potential pitfalls. Additional information will include the appropriate diagnostic workup, operative setting, and patient selection. The interactive format will allow the participant to know if he understands basic techniques and is ready to incorporate sialendoscopy in his practice.
(1) Use basic instrumentation for sialendoscopy. (2) Describe appropriate patient selection for sialendoscopy. (3) Perform sialendoscopy in your practice while recognizing common mistakes and pitfalls.
Human papillomavirus (HPV)–associated head and neck cancer is an epidemic striking a younger and healthier population without the usual risk factors for head and neck cancer. Most patients have an excellent prognosis following treatment with surgery or chemoradiation, and the sequela of long-term morbidity from treatment is of increasing concern as patients are expected to live long enough to experience complications. Failure to identify a subset of patients at high risk for metastasis, recurrence, and decreased survival can lead to undertreatment and poor outcomes. This miniseminar will discuss the epidemiology, workup, treatment, and surveillance of HPV-positive head and neck cancer.
(1) Describe features of HPV-positive head and neck cancer. (2) Recognize the role of surgical and nonsurgical therapy in the treatment of HPV-positive head and neck cancer. (3) Explain the indications for adjuvant treatment in the management of HPV-positive head and neck cancer.
The next breakthrough in surgery will be intraoperative visualization of key normal structures and diseased tissue in real time using biological targeting compounds. Agents for visualizing blood flow are currently available to evaluate flap perfusion or vessel dynamics and sentinel node detection. Both antibody-based agents and small molecules with high-affinity target binding linked to fluorophores can be detected with high sensitivity using currently available cameras. Agents are being developed for imaging nerves. There are active clinical trials to image cancer cells to ensure complete resection. This miniseminar will provide an overview of agents that are currently available and in development.
(1) Describe the utility of optical imaging in head and neck surgery. (2) Implement currently available optical imaging agents in surgical practice. (3) Analyze validity of new agents and instruments that will be coming to the market for surgical optical imaging.
Nasopharyngeal carcinoma (NPC) is a distinct and important cancer of the head and neck. As the incidence is rare in Whites, diagnosis can be challenging. However, ear, nose, and throat specialists should be able to manage NPC; therefore, the aim is to provide the attendee a great opportunity to be familiar with some of the current knowledge of the management of NPC, including using Epstein-Barr virus (EBV) as a biomarker to diagnose and monitor NPC, evolution of treatment guidelines of NPC, and salvage nasopharyngectomy for local recurrence in this miniseminar.
(1) Use EBV as a biomarker to diagnose and monitor patients with NPC. (2) Recognize the evolution and treatment guideline of NPC. (3) Explain the rationale and the various approaches for salvage NPC (open/endoscopic), treatment results, and prognosticators.
Diagnosis and management of hyperparathyroidism represents a rapidly changing field in surgery. Much of the change is technologically driven, with the advent of high-resolution imaging, intraoperative assays, and application of robust neuromonitoring. These have led to a preponderance of targeted, outpatient procedures that have a high rate of success. As the role of the otolaryngologist in treating this condition continues to be established, mastery of fundamental and emerging concepts is essential. This miniseminar will explore the importance of ultrasound, sestamibi, 4-dimensional (4D) computed tomography (CT), and other imaging options as well as proper use of hormone assays, postoperative management techniques, and the recent controversy regarding 4-gland exploration.
(1) To become familiar with the latest refinements in parathyroid imaging, including high-resolution ultrasound, 4D CT scans, and CT-mibi. (2) To understand the strategy behind focused exploration and the principles promoted by surgeons who routinely perform bilateral neck exploration. (3) To appreciate the nuances of modern postoperative management, including calcium prophylaxis and persistent eucalcemic hyperparathyroidism.
This miniseminar will provide a critical, evidence-based review of current practice regarding laryngopharyngeal reflux with focus on improving patient care. Current paradigms often yield uncertain diagnosis, while prolonged treatment and/or extensive testing are time-consuming and costly, have side effects, and yield equivocal benefit in many cases. Through focus on strengths and weaknesses of various diagnostic strategies and with knowledge of current practice patterns, this miniseminar hopes to identify best practices for evaluation of presumed laryngopharyngeal reflux. This miniseminar aims to recall otolaryngologists to a broader patient-based perspective and refocus attention on better evaluation for complaints possibly related to laryngopharyngeal reflux.
(1) Discuss current otolaryngology practice patterns for patients with presumed reflux disease. (2) Compare the strengths and weaknesses of common approaches to reflux diagnosis such as history, examination, response to empiric proton-pump inhibitor trial, and objective reflux testing. (3) Identify current best practices in otolaryngology care of presumed laryngopharyngeal reflux.
Key aspects of thyroid surgery have been addressed by published clinical practice guidelines, consensus statements, and position papers from the American Academy of Otolaryngology—Head and Neck Surgery Foundation (AAO-HSNF), the American Head and Neck Society (AHNS), and the American Thyroid Association (ATA). This miniseminar efficiently presents these society publications, focusing on their content, interpretation, and limitations. Specific topics include surgery for invasive carcinoma, imaging selection, improving postoperative voice outcomes, nerve monitoring, outpatient surgery, and goiter management. These documents will also be used to highlight the important overall differences between practice guidelines, consensus statements, and position papers and their respective influence on clinical decisions.
(1) Differentiate between a clinical practice guideline, clinical consensus statement, and position paper. (2) Analyze the content, interpretation, and limitations of the key publications sponsored by the AAO-HNSF, AHNS, and ATA regarding the management of thyroid surgical disease.
Evaluation of thyroid nodules with surgeon-performed ultrasound and fine-needle aspiration (FNA), armed with molecular testing, is rapidly transforming thyroid surgery. Didactic presentations and case studies including American Thyroid Association (ATA) guidelines will provide participants with risk stratification using ultrasound and pearls for surgeon-performed FNA. Molecular Classifiers have a 95% negative predictive value for indeterminate nodules reducing unnecessary diagnostic lobectomies. Molecular alteration testing from FNA with panels including BRAF is 100% specific for papillary thyroid cancer and has evolved into next-generation sequencing from the cancer genome atlas (TCGA). Combined mutation marker analysis has improved prognostic information. Personalized thyroid cancer surgical management is approaching.
(1) Explain that Molecular Classifier testing for cytologically indeterminate nodules may reduce the number of unnecessary diagnostic thyroid lobectomies. (2) Recognize next-generation sequencing and the cancer genome atlas for cytologically indeterminate nodules will improve the diagnosis of thyroid cancer. (3) Interpret ATA guidelines for ultrasound, FNA, molecular testing, and prognostication.
Airway, voice, and swallowing complaints following radiation present some of the most challenging clinical dilemmas in otolaryngology. This practice-based minisemiar will bridge current scientific knowledge about radiation and its impact on the larynx with decades of clinical experience dealing with vocal fold lesions, vocal fold paralysis, airway obstruction, dysphagia, and chondroradionecrosis of the larynx. Succinct, highly focused presentations on these topics will aim for the shared objective of distilling key elements of clinical care issues that occur in the radiated larynx. Real-life cases will be presented. Panelists are challenged to provide practical advice for the management of this patient population.
(1) Explain the pathophysiology of laryngeal injury following radiation therapy, specifically as it relates to chondroradionecrosis. (2) Examine the limitations that prior radiation places on the otolaryngologist caring for patients with vocal fold lesions and paralysis. (3) Incorporate state-of-the-art surgical and therapeutic options available for airway and swallowing rehabilitation in the radiated larynx.
This miniseminar will address workup and surgical treatment of acute and chronic bilateral vocal fold immobility due to neurological and mechanical injury. Diagnostic challenges will be discussed including how to determine the cause of immobility and whether to use electromyography. Options for acute treatment will include observation, tracheotomy, the use of botulism toxin, and endoscopic lateralization. We will explore how to choose endoscopic versus open procedures for chronic disease and analyze how the choice of procedure depends on the age of the patient and the cause of immobility. There will be an emphasis on case studies and audience participation.
(1) Differentiate between neurological and mechanical causes of bilateral vocal fold immobility. (2) Consider the advantages and disadvantages of all endoscopic and open procedures for bilateral immobility due to a neurological cause. (3) Consider the advantages and disadvantages of all endoscopic and open procedures for bilateral immobility due to cricoarytenoid joint fixation or glottal stenosis.
Laryngopharyngeal reflux (LPR) is commonly diagnosed in patients seen by otolaryngologists. Prescribing of proton pump inhibitors (PPIs) increased 5-fold from 1990 to 2001 and accounts for 10% of costs in evaluation and management of patients with voice disorders. In response, 46.5% of general otolaryngologists feel they are overdiagnosing LPR. Considering this, what diagnoses are otolaryngologists missing due to the reflexive diagnosis of LPR? The goal of this program is to present a clear clinical approach to the diagnosis and treatment of patients complaining of LPR-like symptoms and suggest alternative diagnoses and treatments as well as an approach to patients unresponsive to PPI therapy.
(1) Diagnose efficiently and effectively treat a patient who has LPR-like symptoms but is unresponsive to PPI management. (2) Describe the unified airway concept and how it alters the diagnostic and therapeutic approach to patients with LPR-like symptoms. (3) Implement treatment for postviral vagal neuropathy and irritable larynx syndrome.
Injection laryngoplasty has a long history in vocal fold augmentation, and its use continues to evolve in otolaryngology. This miniseminar will provide a contemporary update on the indications, injectable materials, operative techniques, and potential pitfalls of injection laryngoplasty in modern otolaryngology practice. Particular attention will be paid to the latest developments in injection materials and office-based injection techniques for the general otolaryngologist. In addition, the presentation will include case presentations of pitfalls in injection laryngoplasty with a candid discussion of the inherent risks and possible mistakes that can be made with this technique and how to avoid them.
(1) Define the various indications for injection laryngoplasty in modern otolaryngology practice and recognize the benefits and controversies of currently available injection materials for laryngoplasty. (2) Compare the benefits and indications for clinic or office-based injection techniques, including thorough descriptions of clinic-based injection techniques. (3) Recognize potential patient care risks with injection laryngoplasty and methods to avoid or ameliorate these risks.
The purpose of this miniseminar is to present the contemporary management of cough. This miniseminar will thoroughly cover the most common etiologies of cough and its current management. A description of the sensory receptors, hyperexcitability related to neuropathy (including postviral), pharmacologic suppression of hyperexcitability, and management of pertussis (whooping cough) will be presented. If time allows, a few difficult cases will be presented that highlight the current management strategies.
(1) Explain the multiple etiologies for cough and its management. (2) Examine the complex relationship between the cough receptors and the larynx. (3) Illustrate pertussis resurgence and contemporary management.
This course will provide a comprehensive review of unilateral vocal fold paralysis (UVFP) management. The causes and workup of UVFP will be discussed. Special attention will be paid to office evaluation including utility of stroboscopy and laryngeal electromyography. Intervention including operating room–and office-based injection laryngoplasty will be described. The benefits of thyroplasty, arytenoid adduction, arytenopexy, and reinnervation will be debated. Case presentations will be used to highlight teaching points. Ample time will be allotted for audience participation and questions.
(1) Describe how to perform a vocal fold injection. (2) Compare different methods to treat unilateral vocal fold paralysis.
The goals of cholesteatoma surgery are the complete removal of disease while minimizing the risk of recurrence. A secondary goal is to optimize postoperative hearing. This miniseminar features distinguished experts in the field who will present well-established methods of cholesteatoma surgery. Important topics, such as intact-canal-wall versus canal-wall-down surgery, recurrence prevention, use of cartilage, and management of labyrinthine fistula will then be discussed in a case-based format. The role of endoscopes and use of magnetic resonance imaging for detection of recurrence will be discussed. Finally, ossiculoplasty techniques will be presented.
(1) Perform cholesteatoma surgery as practiced by experts in the field. (2) Examine advantages and disadvantages of endoscopic techniques. (3) Incorporate various methods for preventing recurrence.
The single-sided deafness (SSD) handicap has been underestimated. The purpose of this miniseminar is to present the latest research on the benefits of binaural hearing (Sig Soli, PhD), and the impact of SSD on childhood development and school performance (Nancy Young, MD). The different rehabilitation methods available will be presented, including osseointegrated bone conduction technologies (Jack J. Wazen, MD) and nonsurgical options (John Goddard, MD). Future trends and clinical research on the use of cochlear implants in SSD will be presented (Bruce Gantz, MD, and Tom Roland, MD). Open discussion, questions, and audience participation will follow the presentations.
(1) Recognize the benefits of binaural hearing in children and adults and the potential deficits imposed by SSD. (2) Differentiate between surgical and nonsurgical options in the rehabilitation of SSD. (3) Use developing technologies and clinical research in the rehabilitation of SSD, including the use of cochlear implants.
This miniseminar comprehensively reviews evaluation and management of laryngeal leukoplakia. Although white vocal fold lesions are common, management remains challenging. Doing too little may allow precancerous lesions to progress, while doing too much may create unnecessary dysphonia. Within a framework balancing oncologic with functional outcomes, and using case-based presentations, this miniseminar highlights challenges, controversies, and emerging paradigms in laryngeal leukoplakia care. Perspectives from laryngology, head and neck oncology, and radiation oncology will discuss innovations such as narrow-band imaging, optical coherence tomography, potassium titanyl phosphate (KTP) and CO2 laser, chemotherapy, radiotherapy, and photodynamic therapy as they apply to current and future state-of-the-art management.
(1) Understand the risk of progression of laryngeal leukoplakia to carcinoma and need to balance oncologic efficacy with functional outcomes in leukoplakia care. (2) Review current and emerging techniques for accurate diagnosis, staging, and surveillance of laryngeal leukoplakia. (3) Discuss treatment alternatives for laryngeal leukoplakia, emphasizing surgical techniques of KTP, CO2, and cold-instrument phonosurgery and including potential roles of radiotherapy, photodynamic therapy, and chemotherapy.
Otogenic pain and aural fullness can be some of the more frustrating chief complaints to work up and address. Many patients with this complaint are frustrated with lack of diagnosis and treatment. This leads to multiple visits in search of the answer to their affliction. In this miniseminar, our panel of experts will continue their discussion on how to evaluate and treat these difficult patients. Paradigms for management of these patients will be discussed. Case presentations will highlight proper workup and management of these confusing cases. Sponsored by the Otology and Neurotology Education Committee.
(1) Describe pathologies that may cause otogenic pain or aural fullness. (2) Conduct workup paradigms to avoid missing potentially dangerous processes. (3) Examine possible treatments for the various pathologies.
More than 50 million people in the United States have reported experiencing tinnitus, an estimated prevalence of 10% to 15% in adults. The multidisciplinary American Academy of Otolaryngology—Head and Neck Foundation–developed “Clinical Practice Guideline: Tinnitus,” will be presented. This guideline provides evidence-based recommendations for clinicians managing patients with tinnitus. The guideline discusses evaluation of patients with tinnitus, including selection and timing of diagnostic testing and specialty referral to identify underlying treatable pathology. It then focuses on the evaluation and treatment of patients with persistent primary tinnitus, with recommendations to evaluate and measure its impact, for determining the most appropriate interventions to improve symptoms and quality of life for tinnitus sufferers.
(1) Practice accurate and efficient diagnosis of primary tinnitus. (2) Improve the quality of care and mitigate the personal and social impact of persistent, bothersome tinnitus.
Sponsored by the American Neurotology Society, this interactive presentation aims to provide general practitioners tips and techniques employed by experts in management of intraoperative complications encountered during common otology cases such as tympanoplasty, tympanomastoidectomy, and stapedotomy. The panelists will present illustrative cases and discuss best practice approaches to intraoperative cerebrospinal fluid (CSF) leak and encephaloceles, facial nerve injury, vascular complications, stapedotomy challenges, ossicular chain and external auditory canal damage, and inner ear violation.
(1) Recognize unexpected circumstances and anatomic variations that could lead to complications in otologic surgery. (2) Manage intraoperative complications such as facial nerve palsy, vascular injury, encephaloceles, CSF leaks, postoperative sensorineural hearing loss, and vertigo.
A neurobiology for all clinical types of tinnitus is emerging reflecting advances in the basic science and neuroscience of brain and brain function and the cochleovestibular system. As tinnitus types begin to be objectively identified, treatment modalities can be applied in a more precise manner. The goal of this miniseminar is to examine new and existing tinnitus treatment specifically in reference to how to apply these techniques for the different tinnitus types. Surgery, intratympanic treatment, neuromodulation, and magnetic stimulation will all be examined, allowing the participants to understand the cutting edge of tinnitus therapy.
(1) Cite the clinically applicable methods of tinnitus treatment. (2) Determine the rationale for selection of modality(ies) of treatment based on objective identification. (3) Describe the variety of tinnitus types that can now be diagnosed in an objective manner.
Endoscopic ear surgery (EES) is a current hot topic in our specialty; however, it is not entirely correct to introduce EES as “new.” Although not new, it is clear that during the past few years, endoscopes have proven to be safe and effective instruments to manage ear diseases in a minimally invasive way, preserving important anatomic structures, allowing functional approaches to well-known conditions. Moreover, endoscopes have provided a better view and understanding of traditional middle ear anatomy and physiology, allowing new landmarks, novel concepts of tissue preservation, ventilation routes, and management of other conditions within the middle ear and beyond.
(1) Describe the endoscopic anatomy of the middle and inner ears, discussing the concepts of related physiology. (2) Examine totally endoscopic and combined surgical approaches to middle ear conditions, discussing the possible advantages and disadvantages. (3) Present the instruments needed, system setup, surgical skills, learning curve, and also some important tips and pearls to surgeons to start doing endoscopic ear surgery.
Chronic otitis media is a condition commonly encountered by otolaryngologists. During this miniseminar, we will cover the fundamentals of managing chronic otitis media, medically and surgically, in a case-based, interactive format. Particular emphasis will be given on how to recognize, evaluate, and avoid or treat common complications of chronic otitis media. Specifically, the presentation will include the following topics: managing the tegmen and dura, facial nerve, vascular injury, otic capsule, and ossicular erosion; recurrent disease; and intracranial complications. This presentation will assist the otologic surgeon in the pre-, intra-, and postoperative care of patients with chronic otitis media.
(1) Recognize the most common complications of chronic otitis media. (2) Interpret critical findings that will alert the clinician to the presence of a complication from chronic otitis media. (3) Implement management strategies that will assist in the care of patients with chronic otitis media with attention to intraoperative findings.
The “dizzy” patient can be a diagnostic challenge. Symptoms can be nonspecific and result from numerous etiologies. While most otolaryngologists realize that a complete and accurate history provides the basis for the diagnosis and management of balance disorders, the use and diagnostic significance of balance tests can be unclear. In this miniseminar, we will discuss the use and interpretation of a variety of balance tests including electrocorticography, vestibular evoked myogenic potential, videonystagmography testing, rotational chair testing, head impulse tests, and posturography. The goal of this miniseminar is to educate and discuss the use of these tests in a modern practice.
(1) Identify history and physical examination findings that indicate the need for further diagnostic testing. (2) Decide which balance tests to order when further testing is necessary. (3) Interpret balance function testing for diagnostic and prognostic purposes.
Through this interactive presentation, the audience is exposed to challenging temporal bone radiology cases and offered strategies to improve their interpretation. We will cover key findings for chronic ear disease and conductive hearing loss, lateral skull base lesions, and the petrous apex. The emphasis is placed on subtle but pertinent findings on computed tomography and magnetic resonance imaging examinations and their importance in creating and narrowing a differential diagnoses. We will present guidelines to aid in the efficient acquisition and interpretation of imaging for patients with common otologic symptoms such as vertigo, sudden hearing loss, and pulsatile tinnitus.
(1) Interpret key radiographic findings for common pathologic conditions of the temporal bone. (2) Order appropriate radiographic tests to evaluate common conditions and understand the strengths and limitations of various imaging modalities.
Sudden hearing loss is a complex, frightening condition with a number of possible causes and treatments. There is exciting new research with immediate clinical application. This miniseminar will provide a Clinical Practice Guidelines–based review of targeted evaluation and treatment options and a detailed look at current research, particularly for the problem of the patient with sudden sensorineural hearing loss (SSNHL) who does not respond to first- or second-line treatments.
(1) Demonstrate an evidence-based strategy for workup, evaluation, and counseling of the patient with SSNHL. (2) Compare existing treatment modalities using the available evidence and offer the appropriate treatment for the patient. (3) Recognize the latest research in treating other treatment-resistant SSNHL.
Idiopathic sudden sensorineural hearing loss (ISSHL) has no known etiology. However, numerous studies have addressed this important problem. This miniseminar, sponsored by the American Academy of Otolaryngology—Head and Neck Foundation (AAO-HNSF) Otology and Neurotology Education Committee, will summarize existing literature with regard to the evaluation and treatment of ISSHL. We will review AAO-HNSF guidelines, studies on the efficacy of steroids, antivirals, hyperbaric oxygen, and other treatments. Lastly, we will discuss treatment options when hearing does not recover.
(1) Implement the recommended evaluation of patients with sudden hearing loss. (2) Recognize the benefits of oral versus intratympanic steroids for sudden hearing loss. (3) Analyze the utility of nonsteroidal treatments when steroids and other modalities fail.
Dizziness and balance problems are very common in older adults. These problems can be vexing to manage for the otolaryngologist given that symptoms are often nonspecific, and multiple vestibular and nonvestibular factors are typically involved. In this miniseminar sponsored by the Geriatric Otolaryngology and Equilibrium Committees, we will review the latest evidence on how vestibular function changes with age and how this affects mobility and falls risk in older adults. We will discuss a practical, evidence-based approach to identifying important vestibular and nonvestibular contributing factors (eg, benign paroxysmal positional vertigo in elderly patients, orthostatic hypotension, specific medications), and strategies for managing these factors.
(1) Describe multiple contributing factors to dizziness in older adults. (2) Explain how vestibular function changes with aging and how this affects mobility and falls risk. (3) Enhance the diagnosis and management of vestibular dysfunction in older adults.
More than 3500 battery ingestions occur each year in the United States. Over the past 8 years, the number of moderate to severe injuries has increased, including fatalities. A multidisciplinary national button battery task force was set up in 2012 under the American Broncho-Esophagological Association and the American Academy of Pediatrics with the overall mission of reducing button battery injuries in children. This miniseminar aims to outline the current status of the problem, insights into clinical management algorithms, industry involvement, product safety standards, and educational outreach activities. All task force activities will be discussed.
(1) Discuss the incidence of button battery ingestions, mechanisms of injury, clinical presentation, and common household sources of button batteries. (2) Implement treatment algorithms and be able to recognize immediate and delayed complications. (3) Implement solutions with industry collaboration and educational outreach efforts to prevent future button battery injuries.
This clinical consensus statement was developed by a multidisciplinary panel of experts to improve patient care and outcomes for pediatric patients with chronic and recurrent rhinosinusitis. Clinical statements were developed using the modified Delphi technique to optimize expert consensus. Clinical statements were developed to specifically address differences between and within medical disciplines regarding the diagnostic methods for pediatric rhinosinusitis and in both the medical and surgical therapeutic approaches for the management of pediatric rhinosinusitis. This miniseminar will review the key results of the panel’s efforts as well as critically assess the available, supporting evidence.
(1) Review the key clinical factors that distinguish acute and/or chronic rhinosinusitis from other common illnesses such as viral upper respiratory infection or allergic rhinitis. (2) Assess the most useful diagnostic measures to establish the diagnosis of rhinosinusitis in children. (3) Explore the stepwise recommended medical and surgical treatment approaches for pediatric rhinosinusitis.
This panel format miniseminar will provide perspectives on best practices in care of the pediatric tonsillectomy patient with regard to anesthetic practices, criteria for admission, and pain management. The goals of the presentation are to provide guidelines for safe and effective pain management, raise awareness regarding “red flags” in children who may require advanced anesthesia expertise, and propose algorithms for identifying and managing those children who may be at high risk for complications.
(1) Provide safe and effective nonnarcotic postoperative pain management in pediatric tonsillectomy patients. (2) Identify children at increased risk for posttonsillectomy complications. (3) Recognize patients who will most benefit from the expertise of a pediatric anesthesiologist and/or a higher level of postoperative care.
Sleep-disordered breathing (SDB) affects more than 10% of all children, and tonsillectomy and adenoidectomy (T&A) is one of the most common surgeries done nationally. This miniseminar will review available current national guidelines on evaluation of SDB, including the use of polysomnogram and indications for T&A. Outcomes in routine, syndromic, obese, neurologically affected, and other cases will be reviewed. Lastly, surgical options for failures to cure with T&A will be discussed. Case studies will be presented that will demonstrate principles presented and foster discussion among panelists.
(1) Describe patient characteristics that necessitate evaluation with polysomnogram versus proceeding with treatment based on clinical history and examination. (2) Identify common reasons for failure to cure SDB with routine T&A. (3) Demonstrate knowledge of available surgical options for these cases.
In this state-of-the-art miniseminar, 7 experts will share video-based examples of new ideas in pediatric otolaryngology. New knowledge, techniques, and outcomes for emerging concepts will be discussed while ample opportunity for audience questions and answers will be provided. Steven L. Goudy: endoscopic-assisted pharyngeal surgery. Christopher J. Hartnick: optical coherence tomography in the operating room; differentiating cysts from nodules. Sanjay R. Parikh: drug-induced sleep endoscopy: technique and findings. Soham Roy: mechanical models of operating room airway fires. Michael J. Rutter: slide tracheoplasty for difficult tracheoesophageal fistula. David R. White: a new understanding of congenital nasal stenosis. Carlton J. Zdanski: transoral robotic surgery: pearls and pitfalls.
(1) Characterize novel ideas for pediatric airway surgery techniques and concepts. (2) Prevent airway fires during surgery. (3) Practice novel techniques for understanding pediatric sleep apnea evaluation.
Rhinologic diagnostic and treatment problems commonly create dilemmas in practice. This miniseminar provides for interactive discussion of the management options and the decision rationale involved in difficult sinus diagnostic and treatment situations. A case presentation format is used with case presentations from each of the panelists emphasizing questions with regard to differential diagnosis, evaluation, imaging, and treatment. Cases are representative of those encountered by either a general otolaryngologist or a subspecialty rhinologist but have critical decision points for discussion. The session focuses on the decision-making process, frontal sinus disease, revision surgery, and fungal sinusitis, as well as common tumors.
(1) Review the surgical decision-making process in chronic sinus disease. (2) Implement different imaging modalities and improved quality of interpretation for both computed tomography and magnetic resonance images. (3) Improve the management of difficult-to-treat chronic rhinosinusitis.
This miniseminar includes 3 didactic lectures, an audience-interactive section, and Q&A. The lectures will focus on why food allergies develop by taking a critical look at the latest scientific evidence available in the literature, the role of oral tolerance in human evolution, and the relationship of failure to achieve oral tolerance on the health of the individual, relevant immunology, nonimmunologic food reactions versus immunologic reactions, both IgE-mediated and non–IgE-mediated, current methods of diagnosing food allergies, cutting-edge strategies such as component-resolved testing, skin and in vitro methods versus double-blind, placebo-controlled food challenge. Treatment options for food allergy will also be discussed.
(1) Evaluate the scientific basis of IgE- and non–IgE-mediated food allergy. (2) Describe the manifestations of food allergy in the head and neck region. (3) Use the currently available treatments for food allergy as well as future directions.
Chronic sinusitis with nasal polyposis has a detrimental impact on quality of life and may exacerbate coexisting conditions such as asthma. This miniseminar will outline the latest theories on disease pathogenesis as well as promote rational medical and surgical strategies for severe nasal polyposis management. Treatments designed to decrease reliance on systemic steroids including surgical methods and complementary medical therapeutics such as topical steroid irrigations, macrolides, and anti-leukotrienes will be discussed. A panel of international experts will provide the latest innovations in medical and surgical treatments through a case-based approach of difficult patients and strategies for success illustrating these advancements.
(1) Describe current theories on the pathogenesis of nasal polyposis. (2) Recognize the newest medical and surgical treatments for difficult nasal polyposis, including cystic fibrosis. (3) Initiate additional therapeutic measures to appropriately care for patients with severe nasal polyposis.
Allergic rhinitis is a worldwide health problem affecting 30 to 60 million people in the United States annually, including up to 30% of adults and as many as 40% of children. The multidisciplinary, AAO-HNSF-developed Clinical Practice Guideline: Allergic Rhinitis, will be presented. The evidence-based recommendations are designed for clinicians involved in the diagnosis and management of patients with allergic rhinitis.
(1) Properly diagnosis allergic rhinitis. (2) Differentiate between allergic and non-allergic rhinitis. (3) Know when to perform allergy testing; and understand the role of immunotherapy (sublingual and subcutaneous).
Some of the most exciting new research in the field of chronic rhinosinusitis (CRS) relates to topical therapies. These therapies include topical steroids, antibiotics, antifungals, surfactant, and complementary and alternative treatments such as manuka honey and bacteriophage. New research now supports the clinical use of these therapies. However, some topical therapies proposed for treatment of CRS and related disorders should be used with caution due to lack of efficacy and even toxicity. The purpose of this miniseminar is to provide a summary and case studies of the best evidence available to help clinicians treat patients with CRS using topical therapies.
(1) Analyze up-to-date evidence-based research for topical therapy management of CRS including topical steroid, antibiotic, antifungal, surfactant, and other alternative remedies. (2) Apply evidence-based clinical research in this field to directly improve the therapies available for patients with CRS.
Patients with nonallergic rhinitis (NAR) are commonly seen in an otolaryngologist’s practice. These patients may have no allergic triggers, may be negative to routine allergy testing, and are therefore diagnosed with NAR. Recent workgroups both in the United States and internationally have attempted to better classify the pathophysiology and phenotype of patients with NAR, with the goal of facilitating more accurate diagnosis and improved treatment. This panel will review, through brief didactic discussions and case presentations, recent knowledge and current understanding of NAR and will highlight methods to improve the management of these frequently challenging patients.
(1) Discuss the various pathophysiologies and presentations that are grouped under the diagnostic category of nonallergic rhinitis. (2) Review important elements of the diagnostic workup in evaluating the patient with nonallergic rhinitis. (3) Implement treatment strategies for patients diagnosed with nonallergic rhinitis.
The risk of serious complications during endoscopic sinus surgery (ESS) is ever present. It is the responsibility of the operating surgeon to minimize the risks through meticulous preoperative preparation, careful operative technique, and diligent postoperative care. This miniseminar brings together some of the top sinus surgeons from around the world to share some of their technical pearls and experience regarding the treatment and avoidance of complications in ESS, as well as the latest research in the field. Through the use of clinical case-based vignettes, topics that will be covered include CSF leak, orbital injury, and catastrophic hemorrhage.
(1) Identify high-risk situations preoperatively in patients undergoing functional ESS (FESS). (2) Apply intraoperative measures and technical pearls to avoid serious complications during FESS. (3) Elaborate a clear plan for the management of intraoperative emergencies, including orbital hematoma and internal carotid artery injury.
With continual advances in endoscopic instrumentation and technology, a burgeoning number of rhinologic procedures can now be effectively performed in the office environment. Such interventions have provided therapeutic alternatives in the management of primary and recalcitrant sinonasal disease. The purpose of this miniseminar is to describe the principles and techniques involved in successful implementation of rhinologic surgery in the clinic setting. Both fundamental (turbinate surgery, polypectomy) and advanced sinus procedures (frontal sinusotomy, revision surgery) will be discussed. Appropriate setup, anesthesia, and patient selection will be described. This miniseminar will be conducted by academic leading rhinologists using a multimedia, interactive, case-based format.
(1) Discuss current office-based, rhinologic surgical procedures and their role in the management of sinonasal disease. (2) Describe appropriate patient selection, preparation, and optimal anesthetic and surgical techniques for rhinologic clinic procedures. (3) Assess recent technologic innovations and understand their proper application in rhinologic office-based surgical procedures.
Although our understanding of chronic rhinosinusitis (CRS) has improved, patients prove to be a diagnostic and therapeutic challenge. The variability in presentation contributes to the difficulty in providing effective medical and/or surgical therapy for each patient, and straightforward, all-encompassing guidelines are lacking. As more innovative treatments arise, choices available to otolaryngologists become overwhelming. The purpose of this miniseminar is to provide a stepwise approach to the overall management of CRS patients. The panelists will cover aspects of patient care including evaluation and diagnosis, tailored medical management, surgical choice and optimization, and postoperative management.
(1) Evaluate patients presenting with CRS and provide medical/surgical management recommendations for specific categories of CRS. (2) Discuss methods for improving surgical outcomes and recommend appropriate use of surgical devices/products for CRS. (3) Provide recommendations for effective postoperative management, use of subsequent in-office procedures, and continued medical treatments for CRS.
Modification of uvulopalatopharyngoplasty (UPPP) as well as variation in treatment of hypopharyngeal obstruction are numerous. Selecting the right technique for the right patient often becomes the most difficult decision in treatment planning. It is often unclear if the proponents of a particular technique apply their “modifications” for every case or if there is a selection process. The purpose of this miniseminar is to present specific cases and hear the opinion of 5 experts on how they would treat the same patient.
(1) Use the appropriate patient selection for a classic UPPP. (2) Determine when uvula preservation techniques are appropriate. (3) Examine the current thinking in tongue base reduction.
Obstructive sleep apnea (OSA) significantly affects sleep, daytime function, quality of life, public safety, and cardiovascular risk. Although positive pressure remains the primary treatment, suboptimal adherence rates necessitate alternative treatment strategies. Hypoglossal nerve stimulation is a new and emerging treatment option with published prospective clinical trial data. Sleep-boarded otolaryngologists will review the physiology and basic science of upper airway stimulation, demonstrate the current technology and surgical procedure, present safety and efficacy data from recent multicenter clinical trials, and discuss patient selection and cost-effectiveness. A panel will explore future directions and the advantages/disadvantages of this technology as it compares to other sleep apnea treatment options.
(1) Examine the pathophysiology of OSA with a particular focus on the neuromuscular control mechanisms. (2) Interpret the basic science and feasibility studies on hypoglossal nerve stimulation and describe the current technology and surgical procedure. (3) Report the safety, efficacy, and cost-effectiveness data from published prospective multicenter clinical trials.
Since the introduction of endoscopic sinus surgery, surgeons have debated the merits of middle meatus packing. Many surgeons favor a middle meatal spacer, rather than packing, since the former implies an intentional design for better wound healing. Recently, the emphasis has been upon dissolvable or fragmentable materials that may exert positive effects upon wound healing, and a dissolvable stent that provides drug delivery has also been introduced. In addition, some surgeons do not use any materials whatsoever in the middle meatus after surgery. This miniseminar will feature evidence-based reviews of the published trials, as well as practical knowledge from experienced surgeons.
(1) Comprehend the principles of biomaterials selection for placement in the nose and paranasal sinuses. (2) Review principles of postoperative care with an emphasis on integration into the global surgical strategy. (3) Compare various middle meatal spacers, including chitosan, esterified hyaluronic acid, steroid-releasing implant, and synthetic fragmental foam sponge.
Failure of adequate response to endoscopic sinus surgery (ESS) is a frequent cause of frustration to chronic rhinosinusitis patients and their surgeons. Technical execution of ESS may be a factor in some common findings at revision ESS (middle meatal adhesions, lateralized middle turbinate, missed maxillary ostium, residual uncinate process, residual anterior and posterior ethmoid cells, sphenoid ostium stenosis, and frontal recess scarring). Using real-life demonstrative cases, our expert panel will share practical and key technical pearls on optimizing results from ESS. These include simple modifications in surgical techniques, selection of procedure appropriate to disease, and incorporation of state-of-the-art technology (endoscopes, instrumentation, navigation, etc).
(1) Recognize technical causes of failure of satisfactory response from ESS. (2) Implement changes in surgical techniques to optimize technical execution of ESS. (3) Learn to use technology and instrumentation to improve execution and completeness of ESS.
Surgical and medical management of the nasal airway has traditionally not been considered primary indication for sleep disorders’ treatment. Controversy exists over nasal surgery as primary treatment of snoring and sleep apnea. Algorithms to manage sleep-disordered breathing often ignore or dismiss the nasal airway. This miniseminar addresses the following controversies: (1) Is the nasal airway an important contributor to sleep disorders? (2) Does nasal surgery affect sleep? (3) Does nasal treatment affect the use of continuous positive airway pressure? and (4) What is the role and documented effect of nasal surgery sleep apnea treatment in adults and children?
(1) Justify using appropriate evidence-based outcome metrics of medical and surgical treatment of the nose for specific sleep-related breathing disorders. (2) Compare medical outcomes of sleep apnea treatment with and without treatment of nasal obstruction. (3) Describe potential differences and obstacles in treating nasal obstruction using traditional definitions versus treating it as a spectrum of sleep disordered breathing.
Palate surgery is the primary surgical approach for treatment of obstructive sleep apnea. Although uvulopalatopharyngoplasty (UPPP) was described 30 years ago, the past 10 to 15 years have witnessed the development of alternative palatoplasty techniques. This miniseminar draws from leading surgeons who have developed these procedures and/or performed clinical trials related to them. Findings from published studies will enable attendees to learn more about selection from among the procedures for their patients.
(1) Interpret evidence regarding the range of palatoplasty techniques: UPPP, modified expansion sphincter pharyngoplasty (aka functional expansion pharyngoplasty), relocation pharyngoplasty, lateral pharyngoplasty, Z-palatoplasty, and palatal advancement. (2) Identify the key patient characteristics to guide the selection among palate surgery techniques.
Drug-induced sleep endoscopy (DISE) is a novel technique to identify sites of anatomic obstruction that may be amenable to surgery. Although the technical aspect of the procedure is straight forward, the interpretation and management is not. The science of DISE is rapidly expanding, but there are still many gaps. This miniseminar will present a variety of DISE videos. After audience polling, an expert panel will provide their interpretation and management. Both the art and science behind the decision process will be discussed.
(1) Evaluate a DISE video and classify the obstruction. (2) Formulate a management plan for a variety of anatomic sites of obstruction. (3) Predict the best OSA surgical candidates.
Assess the attitude of academic otolaryngology faculty members toward a new electronic medical record (EMR) and determine the impact of implementation on their perspectives.
A longitudinal survey study was conducted from December 2013 to June 2013 at an academic medical center. All otolaryngology and audiology faculty members were serially administered an online, 10-question survey assessing their attitudes toward implementation of a new EMR system. These surveys were completed 3 months prior and 1 and 3 months after implementation. Basic demographic information was also collected.
Thirty faculty members completed all 3 surveys. Compared with respondents over 40 years old, those under 40 years reported being more comfortable with computers (
Younger faculty members appear to be more comfortable with the use of computers. This possibly led them to be more optimistic about the potential benefits of the EMR system. However, implementation appeared to alter both age cohorts’ perspectives, with younger faculty becoming less positive and older faculty becoming more enthusiastic about the EMR’s impact.
(1) Describe the various basic recommended guidelines to safely perform office-based procedures in otolaryngology (levels of anesthesia, staff training, pre/post procedure care, critical equipment and supplies, and hospital transfer). (2) Discuss state-specific guidelines for office-based procedures. (3) Describe the basic equipment and room setup to ensure safe, efficient, and successful office-based procedures for anesthesia without sedation. (4) Develop a national standard for office-based procedures in otolaryngology that will act as a guideline for the office-based surgeon.
Office-based procedures will continue to gain significant popularity in otolaryngology as more surgeons take advantage of this safe and effective alternative to procedures based in the operating room. This paper involved examining the various existing guidelines for office-based procedures, including necessary equipment, staff training, anesthesia protocols, and documentation. The various state guidelines on office-based procedures were reviewed on an individual basis to produce a set of guidelines that any otolaryngologist can use to develop an office-based procedure practice.
A guideline has been developed covering all critical aspects necessary to perform safe, effective, and successful office-based procedures, focusing on anesthesia without sedation, for the otolaryngology surgeon. This guideline will help outline the necessary steps for the creation of an office-based procedure practice for otolaryngologists across the country.
Office-based otolaryngology procedures are quickly increasing in popularity and frequency. National guidelines are necessary to ensure these procedures continue to be successful, safe, and patient focused.
Determine the current cost impact and financial outcomes of robot-assisted surgery in otolaryngology.
A systematic review of the literature with a defined search strategy. Using keywords robotic or robot, ENT or otolaryngology, cost or economic, transoral robotic surgery or TORS, and thyroidectomy or parathyroidectomy, searches were performed on PubMed, MEDLINE, EMBASE, CINAHL, and Google Scholar, and reviewed by the authors for inclusion in the study.
A total of 4 papers were identified as being appropriate for analysis. Two addressed cost impact and financial outcome of robotic thyroidectomy, 1 the cost impact and financial outcome of transoral robotic surgery, and a fourth included otolaryngology robotic surgeries in the profitability analysis of robotic surgery but did not specify case or procedure types. Analyses found robotic thyroidectomy cost prohibitive, though transoral robotic surgery was financially sustainable, as overall costs of care are decreased from reduced length of stay.
There are diverging cost impact and economic outcomes being reported in robot-assisted surgery in otolaryngology. These trends should inform our decisions as to where robotic surgery should be focused to garner greatest cost and economic benefit.
(1) Describe the implementation of Lean Six Sigma (LSS) training within an otolaryngology residency program. (2) Illustrate the challenges and opportunities of project execution. (3) Address the institutional considerations for a successful LSS program.
(1) From July 2013, LSS training and Lean Belt Certification were offered through the IUSM Department of Otolaryngology in collaboration with VA Systems Redesign. (2) The curriculum and training were designed to maximize participant learning and engagement. (3) Resident and faculty initiated LSS projects were reviewed. (4) Participant feedback survey results were collected.
(1) The Lean Belt curriculum and training were completed by some of the residents and faculty to date. (2) Two medical students completed Yellow Belt Certification. (3) Salivary and thyroid gland ultrasound projects and a sterile supply project translate quality improvement and cost savings to patients and the organization. (4) Participant survey results have been overwhelmingly positive. The medical students identified the added value of LSS certification in their residency application process.
(1) Lean Belt Certification can be successfully incorporated into residency training. (2) Projects serve to improve patient care, increase value, and justify equipment and personnel retention and expansion. (3) Most academic centers have the necessary training available either internally or often from affiliated VAMC or Business Schools. (4) The Lean Belt curriculum and training program has since been used by other subspecialty departments. (5) The additional skill sets acquired by LSS trainees increase their confidence in identifying opportunities for improvement in their immediate health care environment.
(1) Understand difficulties associated with free flap monitoring and duty hour restrictions. (2) Describe techniques used to train intensive care unit (ICU) nurses to conduct free flap monitoring. The implementation of resident duty hour restrictions has resulted in a variety of modifications to residency training programs in otolaryngology–head and neck surgery. In those programs using a home call system, monitoring of free flaps in the postoperative period can be associated with difficulties in resident duty hour compliance. We sought to use a carefully constructed training program to transition a portion of free flap monitoring to a skilled group of ICU nurses.
A written reference manual describing the basic concepts behind free tissue transfer and normal free flap physiology was distributed. Nurses received a PowerPoint presentation and completed an online module designed to consolidate the didactic training. Finally, the responsibility of on-the-job training of the nurses was given to the otolaryngology house staff such that each nurse logged and documented 10 flap checks in the presence of a resident.
Thirty patients receiving free flaps were monitored by the ICU nursing team resulting in 100% flap survival.
Transitioning the monitoring of free flaps in the perioperative period to ICU nurses can be accomplished through the following principles: (1) Leadership and participation by the microvascular surgeons at a given institution. (2) Faculty-led didactic and web-based training modules prior to actual training. (3) Significant involvement of the otolaryngology house staff, allowing the ICU nurses to gain proficiency.
(1) Determine patient and provider factors associated with patient dissatisfaction in an otolaryngology clinic. (2) Identify strategies to improve the patient experience.
Patient satisfaction surveys were prospectively collected in an academic otolaryngology clinic from January 2011 through March 2013. Patient variables (age, insurance type, established vs new patient, diagnosis, and treatability of condition) and provider variables (years in practice, subspecialty, and clinic wait time) were retrospectively analyzed to determine factors associated with patient dissatisfaction. “Treatability” was graded on a scale of 1 to 5, with diagnoses having a clear treatment option (ie, tonsillectomy for chronic tonsillitis) = 1, and diagnoses with no therapeutic options available (ie, tinnitus) = 5.
The cohort included 820 patient satisfaction surveys and charts. Stepwise linear regression analysis identified no single patient or provider variable associated with poor satisfaction scores. Cluster analysis evaluating the interplay between variables identified 5 unique clusters of patients. Satisfaction scores in 4 of the clusters were in the 99th percentile, while the remaining cluster ranked in the 10th percentile. This cluster consisted of a higher proportion of new patients with difficult-to-treat otologic conditions who described their wait time as excessive and were more likely to be self-pay.
Several factors influence patient satisfaction in an otolaryngology clinic. In this study, variables associated with lower patient satisfaction scores included patients with longer clinic wait times, “difficult to treat” otologic diagnoses, and new patients. Addressing the issues common in this population to better meet their needs and expectations may improve overall patient satisfaction.
Demonstrate increasing demand of medical students applying to otolaryngology and decreasing supply of available residency training positions after the shift from an early match to conventional matching process. Demonstrate increasing United States Medical Licensing Examination (USMLE) Step I scores among matched otolaryngology applicants over time.
Matching statistics were obtained for first year residency positions through the National Residency Matching Program from 1998 to 2013. Matching statistics were obtained for otolaryngology residency positions through the San Francisco Match from 1998 to 2005. Univariate cross-sectional analysis was performed with a
Comparing the early match time period to the conventional match time period, there was an increase in otolaryngology resident applicants overall (
Eight years ago, otolaryngology changed from an early to conventional time frame matching process. The match is now more competitive, as evidenced by an increase in the overall number of otolaryngology residency applications, an increased number of unmatched applicants, and an increase of 17 points on average among matched applicants on the USMLE Step I Score. Meanwhile, otolaryngology research positions remain more unlikely to fill compared with core positions.
Determine the variables that contribute to non-compliance with showing up to clinic appointments. Patients no-showing to their appointments represent a significant burden to the health care system by decreasing access to care and lost potential revenue. Identifying patient factors correlated with missed appointments may help characterize why these appointments are missed and identify opportunities to help patients get the care they need.
Retrospective chart review. Patients who did not show up to 3 or more clinic appointments in the otolaryngology department in the Henry Ford system in metro Detroit, Michigan, between July 1, 2011, and June 30, 2012, were analyzed. Controls were patients who had appointments on the same day with the same provider as the no-show patients.
A total of 106 patients were identified who no-showed to 3 or more clinic appointments. Younger age, black race, and lower income were found to be significant factors for patients not showing up to appointments on multiple variate model. On logistic regression, Medicaid insurance, closer distance from home to appointment, less bus transfers, and less time by bus travel were also found to be significant for no-showing.
Age, race, and income are significant contributors to patient noncompliance with clinic appointments. Paradoxically, proximity to the clinical appointment location is also a significant factor; we hypothesize this may be the result of relative income inequality in the metro Detroit population. Follow-up studies include analyzing severity of patient complaints and weather as a factor of noncompliance.
(1) Determine whether Accreditation Council for Graduate Medical Education fellowship-trained pediatric anesthesiologists improve the efficiency of pediatric operations at hospitals that do not have dedicated pediatric operating rooms (ORs). (2) Determine what anesthesia practices may account for a difference in efficiency between general and pediatric anesthesiologists.
This retrospective chart review study compared the anesthesia-controlled time (ACT) between pediatric and general anesthesiologists for pediatric adenotonsillectomies performed at an academic county hospital without dedicated pediatric operating rooms (ORs). All patients age 12 years and under who underwent tonsillectomy or adenotonsillectomy from January 2008 to July 2013 at San Francisco General Hospital were included. Patient demographics, surgical time, ACT, and anesthesia techniques were compared between pediatric and general anesthesiologists.
Pediatric anesthesiologists had significantly shorter ACT than general anesthesiologists (33 ± 12 vs 47 ± 15 minutes;
These findings suggest that, at hospitals without dedicated pediatric ORs, staffing pediatric operations with fellowship-trained pediatric anesthesiologists may be an effective strategy for increasing OR efficiency and reducing costs without compromising patient care.
Infantile hemangiomas are the most common benign tumor of infancy and are well known for their rapid growth during the first 6 to 9 months of life, followed by a spontaneous but slow involution. The standard of care is to treat these lesions at an early age with propranolol to expedite the involution process. Residual telangiectasias often result following involution. We evaluated the efficacy of using a diode laser as an adjunct treatment for cervicofacial infantile hemangiomas.
Twenty patients, aged 4 months to 11 years, underwent treatment with a 532-nm diode laser as part of the management for their hemangiomas. The fluence was 10.2 to 25 J/cm2, pulse durations of 36 to 44 ms, spot sizes of 0.7 to 2 mm, and pulse frequency of 3 to 5 Hz. All procedures were performed in the operating room. In order to assess the efficacy, pre- and posttreatment digital photography were evaluated independently by the authors and ranked on a 0 to 4 point scale (0 = no change and 4 = complete response). Adverse reactions were also recorded.
The telangiectasias showed significant improvement following treatment. In more than half of the patients treated, the affected area demonstrated a complete response. No adverse reactions were noted.
A 532-nm diode laser effectively treats the remaining telangiectasias following hemangioma involution. The treatment is well tolerated and demonstrates excellent results. Whether used independently or in conjunction with other treatment modalities, the diode laser should be part of the surgical armamentarium when treating infantile hemangiomas.
Measure the impact of facial lesion reconstruction on observer-graded attractiveness and measures of negative facial perception.
One hundred twenty casual observers viewed images of faces with lesions of varying sizes and locations before and after reconstruction as well as normal comparison faces. Observers rated attractiveness, lesion severity, and how disfiguring, bothersome, and important to repair they considered each face.
Facial lesions decreased attractiveness –2.26 [–2.45, –2.08] on a 10-point scale. Mixed effects linear regression modeling showed this attractiveness penalty varied with lesion size and location, with large and central lesions generating the greatest penalty. Reconstructive surgery increased attractiveness 1.33 [1.18, 1.47], an improvement that also varied with size and location, restoring some lesion categories to near normal ranges of attractiveness. Iterated principal factor analysis indicated the disfiguring, important to repair, bothersome, and severity variables were highly correlated and measured a common domain; thus they were combined to create the DIBS factor score, representing negative facial perception. The DIBS regression showed lesion faces have a 1.5 standard deviation increase in negative perception [DIBS: 1.69 (1.61,1.77)], which decreased by a similar magnitude after surgery [DIBS: –1.44 (–1.49, –1.38)]. These findings also varied with lesion size and location.
Surgical reconstruction of facial lesions increased attractiveness and decreased negative social facial perception, an impact that varied with lesion size and location. This new social perception evidence, when combined with patient and expert perception data, will inform our evidence-based soft tissue reconstructive algorithm.
Analyze outcomes after static sling suspension and orthodromic temporalis tendon transfer reanimation for facial nerve paralysis after definitive cancer resection with flap reconstruction.
Prospectively collected case series in which patient data were collected prospectively from 2004 to 2013 for patients undergoing reconstruction and facial reanimation after resection of malignancy which involved facial nerve sacrifice. Thirty patients were selected for 2 cohorts: static sling suspension (n = 18) and orthodromic temporalis tendon transfer (n = 12). Revision rates, length of stay, complications, time to follow-up, and postoperative symmetry were compared between the 2 groups.
Of the 30 patients, 18 underwent static suspension and 12 underwent temporalis tendon transfer. In the static sling group, 6 patients (33%) were advised to undergo revision compared with 2 in the temporalis tendon group (17%;
There was no significant difference between the reconstruction methods. Static sling was performed more commonly at time of flap reconstruction.
(1) Recognize the potential efficacy of free flap reconstruction performed at a low volume program. (2) Understand how reconstructive microvascular outcomes and success change over 20 years.
A retrospective chart review was performed at a tertiary care academic program on all free tissue flaps from the primary reconstructive surgeon over 20 years (1993-2013). A total of 135 procedures were obtained from operative notes, billing codes, and chart databases. Outcome variables included overall procedure success, need for surgical revision, and complications. Patients stayed in general surgical intensive care and hospital floor units.
Free tissue flaps were successful in 91% of all cases. In the past 13 years, 70 flaps were performed with 3 failures (96% success rate). Take-back rate was 14% of total cases with a flap recovery rate of 50%. Postoperative failure occurred after 72 hours in 70% of cases. Nearly 60% of patients experienced a complication of any type or severity. Twenty percent of successful flaps had a complication, with half due to partial dehiscence. Systemic complications affected 20% of all cases. The average hospital stay for noncomplicated patients was 13 days. There was 1 postoperative mortality. Fibula and radial forearm were the most common flaps, at 44% and 26%, respectively.
Free flap reconstruction of the head and neck can be performed with acceptable outcomes even in low volume settings.
Report a method using a combination of the Furnas and the Mustardé techniques for the treatment of prominent pinna.
All the patients who underwent otoplasty under the supervision of a single surgeon between 1996 to 2013 were included. Surgical technique and complications were analyzed. Major complications were defined as those requiring revision surgery. Mustardé sutures were used to recreate the antihelix and correct upper/middle thirds of the pinna. In the conchal region, both conchal resection and the Furnas conchal-mastoid sutures were frequently used. Prospective outcome measures included overall benefit and patient satisfaction.
A total of 130 patients with protruding ears were operated upon (126 bilateral, 4 unilateral). Therefore, there were 256 primary interventions. Fifteen required a pure Mustardé technique and 4 underwent a pure Furnas technique. Hence, the combined technique was applied to 237 ears. Mean follow-up was 5 years (6 months-17 years). Only 9 (3.5%) required revision surgery owing to unsatisfactory results and 1 (0.04%) due to bleeding. Minor complications included suture extrusion in 35 ears (13.6%), some up to 5 years postop, and 2 patients (0.07%) developed a retroauricular keloid (treated successfully with intralesional triamcinolone). Overall benefit perceived by the patients was reported as good in 77% and satisfactory in 18%.
We present a technique that combines 2 previously well described techniques, using both cartilage resection in addition to permanent sutures. We believe that the good aesthetic results and acceptable number of complications make this technique an appropriate treatment option for patients with prominent ears.
Review a single institution’s experience with free flap reconstruction of the head and neck in patients 80 years of age and older.
A retrospective chart review was conducted of patients undergoing free tissue transfer for head and neck reconstruction in patients 80 years of age and older between 2008 and 2013 at a single academic tertiary care hospital. Main outcomes studied were free flap success rate, postoperative complications, discharge disposition, and length of hospital stay. Independent variables included age, type of reconstruction, and comorbid disease. Patients were stratified into high and low comorbidity groups using the Charlson Comorbidity Index, and associations with outcomes were analyzed.
A total of 65 patients 80 years of age or older were included in the review. There were 2 free flap failures with a success rate of 97%. Nine patients were 90 years of age or older. The average length of stay was 11 days. There were 11 (17%) flap-related complications and 18 (28%) medical complications. There was no difference in medical or flap-related complications between high and low comorbidity groups (
Free flap reconstruction in the head and neck remains a viable option in patients of advanced age. In our experience a comparable success rate with those reported in the literature among all patients has been achieved and the level of comorbid disease has not appeared to adversely affect outcomes.
(1) Discuss relevant tip projection ratios involved in surgical planning of rhinoplasty. (2) Implement findings of meta-analysis in cosmetic surgery planning.
Meta-analysis of journal articles through June 2013. Intervention: Cosmetic rhinoplasty for underprojected tip. Outcome Measurements: Pre- and postoperative Goode Ratio in cosmetic rhinoplasty patients. Null hypothesis: None of 3 techniques provides superior tip projection among: suture, internal graft, and external graft.
External graft techniques, such as Sheen shield grafting, were found to significantly increase tip projection over suture only techniques. External vs suture:
(1) Meta-analysis of the Goode Ratio has never been reported in the literature. (2) No technique has been proven to have significance in the past. (3) External grafts produce a significant change in nasal tip projection over suturing, and internal grafts approach significance. (4) This research allows the surgeon to rank techniques in order of magnitude of change desired.
(1) Recognize reconstructive options for lateral skull base defects. (2) Compare reconstructive techniques, operative times, duration of hospitalization, and need for subsequent flap revisions.
Retrospective review of surgical techniques used at a tertiary academic referral center between 2002 and 2014 to reconstruct lateral skull base composite defects involving facial skin, ear, and temporal bone. Data were analyzed for demographics, tumor characteristics, reconstructive technique, operative time, duration of hospitalization, complications, and outcomes.
Thirty-one patients were identified for inclusion. Lateral temporal bone defects resulted from resection of malignant lesions including squamous cell carcinoma (n = 22), basal cell carcinoma (n = 2), melanoma (n = 4), and sarcoma (n = 3). Defects were reconstructed with musculocutaneous free flaps (n = 9), pedicled latissimus dorsi flaps (n = 6), and pedicled submental flaps (n = 16). All cases involved neurosurgery, neurotology, and head and neck surgery services. Although time required for surgical resection was similar, time savings was noticed with submental reconstruction. Compared with free flaps, submental flap reconstruction was associated with significantly reduced total operative time (mean 578 vs 455 minutes;
The musculocutaneous submental flap provides an excellent option for reconstruction of lateral skull base defects given its proximity, reliability, ease of harvest, and exceptional color match. Submental flap reconstruction was associated with reduced operative times, duration of hospitalization, and flap revisions.
Chimeric anterolateral thigh (ALT) free flaps are comprised of multiple skin paddles or muscular components, which allow for the reconstruction of complex 3-dimensional defects. There is a paucity of data in the literature regarding the outcomes with this reconstructive option. We sought to describe our results with this technique and identify outcome predictors.
Retrospective review of 24 patients undergoing reconstruction with a chimeric ALT free flap at an academic tertiary institution between 2009 and 2013. Demographics, indications, comorbidities, flap and functional outcomes were retrieved from the medical records and review of intraoperative photography. SPSS was used for data analysis.
The mean age was 57 years and the cohort primarily consisted of males (87.5%). The most frequent defects were: through-and-through pharyngoesophageal, n = 12 (50%) and skull base, n = 6 (25%). The flap consisted of double skin paddles in 11 cases (45.3%) and a skin paddle with an independent muscular component in 13 (54.7%). The mean skin paddle area was 62 cm2. There were no total flap losses; partial loss (secondary skin paddle) was observed in 3 cases and was related to severe congestive heart failure (
Chimeric ALT flaps represent an excellent alternative for reconstruction of complex defects. Patients with congestive heart failure, with immunodeficiency, and who are malnourished are at higher risk of partial flap loss. A second muscle paddle might be indicated in these cases.
The aim of our study was to look at patient related outcome measures and complications post–open structure septorhinoplasty performed by the same experienced rhinologist and to look at any factors associated with increased risk for requirement of revision surgery.
Retrospective review of case notes of all patients who underwent septorhinoplasty at the same institute, performed by the same rhinologist, between January 2009 and February 2013. Assessment of patient satisfaction was made using the Rhinoplasty Outcomes Evaluation (ROE) tool.
One hundred seventy patients were included in the study, with mean follow-up of 28.2 months. The most common complication was residual deformity (10/170, 5.9%). Eleven patients required further revision nasal surgery (11/170, 6.5%). There was a statistically significant increase in the ROE scores pre- and postoperatively in all patients undergoing surgery (19.5 ± 9.41 vs 68.4 ± 23.7,
Open structure septorhinoplasty results in a significant increase in patient satisfaction. Our rate of revision surgery is lower than the average reported in the literature. The rate of revision surgery is higher in cases judged to be more complex preoperatively.
(1) Ascertain the safety of topical mitomycin C in the prevention of recurrent keloid scars after surgical excision. (2) Determine the efficacy of mitomycin C in keloid prevention.
This was a prospective pilot study of 10 patients. Between August 2009 and September 2011, subjects underwent surgical excision of keloids located in the head and neck region with a one-time, intraoperative, topical application of mitomycin C. Patients were followed for 12 months postoperatively. During this period, laboratory values reflecting complete metabolic profile and coagulation studies were drawn preoperatively and postoperatively (at 2 weeks and the first, second, and third months). Additionally, photo-documentation was obtained at regular intervals to ascertain the efficacy in prevention of keloid recurrence.
Twelve patients enrolled in the study. Nine patients completed the protocol. Three patients dis-enrolled prior to surgical excision. No patients were lost to follow-up. Analysis of variance performed demonstrating no statistical significance in the variance of the laboratory values. Additionally, no patient demonstrated abnormality of any laboratory value beyond the reference range. Next, clinical examination of the wounds demonstrated no evidence of necrosis or dehiscence. Finally, no wound demonstrated recurrence at the one-year follow-up visit.
Mitomycin C appears safe for topical use after excision of keloids in the head and neck region. This study demonstrates no evidence of recurrence in all patients enrolled and followed for one year.
Describe common cosmetic deformities and options for reconstruction following parotidectomy.
The authors reconstructed parotid defects in 50 patients and will present an algorithm for reconstruction based on volume, location, and coexisting defects.
The parotid gland is the largest salivary gland in the head and neck, occupying a significant tissue volume. While not every parotidectomy requires reconstruction, excision of large parotid lesions, especially those involving the preauricular area, produce sizeable concavity and skeletonization of the mandible. The resulting cosmetic deformity can significantly affect patients’ self-image and negatively impact their quality of life. Free fat, alloderm, superficial musculoaponeurotic system, rotational sternocleidomastoid flap, and free tissue transfer are possible reconstructive options. Choosing an appropriate donor site requires consideration of the volume, location, and coexisting defects. Free fat grafts are best suited for small lateral parotid defects. In larger volume defects the amount of fat reabsorption is variable, making long-term results less reliable. Similarly, the muscle atrophy of rotational sternocleidomastoid flaps limits their use to filling medium- sized defects, and the arch of rotation allows for only middle and inferior filling of the gland. Finally, large volume reconstruction of total parotidectomy defects, with or without skin, is best accomplished with free tissue transfer.
Reconstructing parotid defects slightly increases operative time and blood loss, but patient satisfaction with the cosmetic outcome is high. Regardless of method used, same-stage reconstruction of parotidectomy defects is advocated and of benefit to the patient. An algorithm for choosing one of several reconstructive options is presented.
(1) Describe the usefulness of osteocutaneous forearm flaps in reconstruction of the naso-ethmoid-orbital (NOE) defect. (2) Describe a case series outlining the authors’ experiences with this reconstruction.
A retrospective review and case series was conducted on patients between 2000 and 2014 who underwent NOE involving resections with reconstruction using radial forearm flap. All disease causes were included and all consecutive patients at 2 institutions were analyzed. Aesthetic results, nasal airway, diplopia, and enophthalmus were assessed in recent patients available. Technical feasibility and methods of reconstruction were assessed, including where bone was plated and which portions of the NOE structure were reconstructed. Patient disease outcomes were included to assess the durability of reconstruction for remaining survival period.
Fifteen patients underwent NOE reconstruction in the timeframe studied. Four recent patients reported poor nasal airway, but no diplopia, and no immediate enopthalmus after NOE reconstruction. Patients felt their appearance had been positively impacted by reconstruction. One-third of patients succumbed to disease in the study period within 3 years of reconstruction, but without need for additional reconstructions.
Ostteocutaneous radial forearm flap (OCRFF) is a cosmetically acceptable and functional method of reconstructing a variety of NOE defects. In NOE cancer patients with limited survival, a one-step reconstruction can be serviceable and not require multiple additional procedures, while ensuring aesthetic results and prevention of ocular comorbidity.
Natural sculpturing of the nose during secondary rhinoplasty is the common goal of every rhinoplastic surgeon. Even for the most experienced surgeons, rhinoplasty remains the most challenging of all aesthetic surgeries. The aim of this study is to assess secondary rhinoplasty surgery on patients by presenting the functional and aesthetic techniques, and evaluating the results of the surgical interventions.
Between January 2000 and January 2014, 1242 secondary rhinoplasty surgeries were performed on 162 males and 1080 females with a mean age of 26 years. Open rhinoplasty surgery was performed on 1170 patients, and closed rhinoplasty surgery was performed on 252 patients. A total of 108 surgeries were performed with local anesthesia and 1134 surgeries under general anesthesia, with or without submucosal reduction of septal deviation and inferior turbinectomy. Septal, auricular, or costal cartilage graft reconstruction was also performed. The reconstructive and aesthetic techniques were performed on 9 different categories. The patients’ functional and aesthetic results were then evaluated.
All patients reported significant aesthetic, olfactory, and respiratory improvement: 990 excellent results, 216 good results, 36 average results, 0 mediocre results.
Advances in rhinoplasty techniques allow satisfactory results in secondary rhinoplasty that were not possible in the past. Furthermore, the choice of a qualified surgeon is of paramount importance. Only the surgeon that has great skills, and who is experienced, careful, and artistic, will make all the difference in achieving great results in the surgical procedure.
(1) Rhinoplasty is the treatment of choice for patients with crooked nose deformity. (2) Objective assessment of nasal and facial profile using digital photographs and computer software is an integral part of management. (3) Recognize that subjective evaluation of patient satisfaction regarding aesthetic improvement is an important aspect of rhinoplasty.
A prospective study from January 2011 to September 2012. Crooked nose deformity in 20 cases of either sex in the age group of 18 to 40 years. Setting: Pt. BDS Post graduate Institute Medical Sciences Rohtak, India, a tertiary care center. Rhinoplasty was performed through the external approach, and aesthetic improvement was evaluated through photographic analysis. Patient satisfaction was also assessed using a visual analog scale of 1 to 100. Independent Variables: Age, sex, external nasal deformity, and nasal septum deviation.
Statistical analysis was done using IBM SPSS v.20 software by paired “t” test. The preoperative nasal deviation alignment angle was 13.76° ± 5.21° while in the postoperative period it was 3.07° ± 2.08° (
Objective assessment and documentation of nasal deformities is an integral part of rhinoplasty. Subjective evaluation, on the other hand, is a useful tool to assess the degree of patient satisfaction.
Venous malformations (VMs) are the most commonly encountered vascular malformation of the cervico-facial region. Their clinical spectrum is extremely variable as they can present as single small lesions (often confined within muscle fasciae) or huge infiltrating ones. They can be part of a syndrome, as with Bean Syndrome, or in cutaneous mucosal venous malformation syndrome, among others. The aims of the study were: (1) Diagnose and stage a cervico-facial VM. (2) Describe the available treatment for head and neck VMs. (3) Propose the most appropriate treatment based on the staging of the VM.
A review of the pertinent literature was performed to provide the common indications and techniques to treat head and neck VMs. Thirty-four consecutive cases of VMs have been treated by the authors by means of endovascular sclerotherapy with sodium tetradecyl sulphate, surgery, or both. Only patients with intraosseous VMs (8 total) were treated by surgery alone. Three large, unresectable cervicofacial VMs were treated by means of the “strangling technique.”
Good to very good aesthetic and functional results were obtained in all 34 patients. All 26 patients who underwent sclerotherapy experienced significant swelling. Six cases of skin or mucosal ulcerations were noted. No damage to the facial nerve was observed. Five patients affected by larger VMs showed partial recanalization/recurrence of the malformation.
Cervicofacial VMs have to be managed by an experienced, multidisciplinary team. A protocol with increasing invasiveness is proposed to maximize results after their treatment.
Airway stabilization is critical in combat-related maxillofacial injury as normal anatomical landmarks can be obscured by blood and debris. The objective of this study was to characterize the epidemiology of airway management in maxillofacial trauma.
A total of 1345 military personnel with combat-related maxillofacial injuries were retrospectively identified from the Expeditionary Medical Encounter Database using ICD-9-CM diagnostic codes. Maxillofacial injury severity was quantified with the Abbreviated Injury Scale (AIS). Service members with maxillofacial injury and severe combat trauma were included in the analysis (n = 239). Study variables included the frequency and timing of intubation, presence and severity of burn injury, frequency of tracheostomy, and presence of inhalational injury.
A total of 239 severe maxillofacial injuries were identified. The most common mechanism of injury was Improvised Explosive Device (IED) (66%), followed by gunshot wounds (8%), mortar (5%), and landmines (4%). A total of 51.0% of the subjects required intubation on their initial presentation to triage facilities. Field surgical airways were rare, but demonstrated a 75% success rate. Of the patients who underwent bronchoscopy, 65.2% were found to have airway inhalational injury. There was a significant relationship between the severity of facial injury and the need for intubation on initial presentation (
There is a high incidence of airway injury in combat-related maxillofacial trauma, which may be underestimated. Airway management in this population requires a high degree of suspicion and low threshold for airway stabilization.
(1) Describe 3-dimensional (3D) computed tomography (CT) anatomic features of the stylohyoid chain in Eagle’s syndrome patients (ES), glossopharyngeal neuralgia patients (GPN), and normal asymptomatic controls (NC). (2) Understand 3D-CT features findings associated with Eagle’s syndrome.
Retrospective chart review from November 2000 to November 2013. 3D shaded surface display CT reconstructions of the stylohyoid chain were generated for 10 ES patients, 16 GPN, and 15 NC patients. Demographic and clinical symptom data were recorded. Anatomic data collected from CT scans included: length of ossified styloid process, anterior-posterior (APA) and medial-lateral (MLA) styloid process angulation, ossification pattern of the stylohyoid chain, and minimum distances between the styloid process and the internal carotid artery, C1 transverse process, and tonsillar fossa.
The average distance from the styloid process tip to the tonsillar fossa was found to be significantly shorter in ES patients (12.7 mm) compared with GPN (21.4 mm;
The styloid process was found to be significantly closer to the tonsillar fossa in ES patients as compared to GPN and NC patients by 3D-CT reconstructions. No significant differences were found in other measures, including styloid process length. Distance to the tonsillar fossa may be a more appropriate diagnostic criterion for ES than styloid process length, and may contribute to the pathophysiology of ES.
(1) Characterize opinions of applicants participating in simulation during an otolaryngology interview process. (2) Describe the effect of task simulation on applicant impression of the host program. (3) Evaluate correlation between objective simulation performance and traditional rank order methods.
Applicants completed pressure equalization tube (PET) insertion on a simulator following an instructional presentation. A published global rating scale (GRS) was completed by the resident proctor and time to completion was recorded. Applicants were informed that scores were not used in final rank order list. After the interview an online survey was sent to the applicants.
Forty-eight applicants completed PET simulation. Survey response rate was 81% (39/48). Inclusion of a simulation exercise during interviewing positively changed the opinion of 21% (8/38) of the applicants, with 1 negative response. The majority of respondents (88%) had no negative response to inclusion of simulation if GRS scores are not included in ranking process. If GRS results are used for ranking, respondents felt it was more fair if the task was non-novel versus novel (54% vs 23%). The inclusion of GRS results in ranking engendered negative opinions of the program (28% non-novel task, 46% novel task). Mean GRS score for applicants was 16 ± 0.98. Time to completion and GRS score were correlated (
Simulated task performance may provide complementary information to that of traditional interviews. Inclusion in ranking may negatively affect resident perception of the program, notably if the task is novel.
Immunoglobulin G4-related disease (IgG4-RD) is a poorly understood chronic inflammatory disorder affecting the middle aged and elderly that can present to the otolaryngologist. We aim to summarize the current literature by performing a systematic review as well as describe our institutional experience with 8 patients.
Our search used Pubmed, Ovid, and Scopus using the keywords IgG4 related disease, head and neck, orbit, salivary glands, sialadenitis, Kuttner, angiocentric eosinophilic fibrosis, submandibular, lacrimal, thyroid, dacryoadenitis, nasal, sinus, paranasal, and Mikulicz’s. Original research and review articles published in English from 1964 to 2013 whose major topic was IgG4-RD affecting the head and neck were included. Data regarding the various presentations and management of IgG4-RD were summarized. Additionally, we present our own experience with a series of 8 patients diagnosed with this condition.
One hundred twenty-four articles met our inclusion criteria. IgG4-RD most often presents as a mass lesion in the head and neck region. Common diagnostic features include: (1) elevated serum IgG4 level, (2) marked infiltration of exocrine glands by IgG4-positive plasma cells with fibrosis, and (3) marked improvement with corticosteroid therapy. Early diagnosis and involvement of rheumatology is important in management.
IgG4-RD is a challenging nonsurgical disease that has multiple manifestations in the head and neck. It must be distinguished from various mimics including malignancy, systemic diseases, and infectious. Otolaryngologists should be aware of this condition and its management.
(1) Characterize contemporary utilization patterns of a stand-alone otolaryngology emergency room (ER). (2) Assess the range of otolaryngologic complaints. (3) Determine characteristics of patients that require inpatient admission. (4) Provide a practical discussion about the utility of a specialized ER in otolaryngologic care.
Retrospective review of demographic and diagnostic data for all patients with an otolaryngologic complaint evaluated at our institutions ER from January 2011 through September 2013. Descriptive analysis was performed to characterize utilization and diagnostic patterns. Multivariable regression modeling was used to identify predictors of inpatient admission. Geocoding analysis was performed to characterize the ER catchment area.
A total of 12,234 patient visits were evaluated. Mean patient age was 44.7 years with equal sex distribution. The majority of visits occurred during daytime hours (75%) with peak volume occurring mid-day. Auditory and vestibular problems constituted the most frequent presenting complaints (50.0%). The majority of patients were discharged home (92.3%). Significant predictors of inpatient admission were pediatric designation (odds ratio [OR] 1.9,
This study provides a contemporary analysis of patterns of specialized otolaryngology ER care in the United States. This study has broad implications for otolaryngology care and resource utilization in the emergency care setting.
(1) Understand evolving national trends in diagnosis and management of reflux disease. (2) Be able to analyze these by provider specialty.
National Ambulatory Medical Care Survey (NAMCS) data for time periods 1998-2001, 2002-2005, and 2006-2009 were reviewed for number of visits, provider type, and prescriptions provided.
Addition of 2 more 4-year periods to previously reported data demonstrates increasing ambulatory visits for reflux across all races, sexes, and age groups. In 2006-2009, there were 15,750,000 visits for reflux, representing 6.9 visits per 100 people on a population basis. Overall visits increased across each sequential time period for internal medicine, family, and gastroenterology physicians. Among otolaryngologists, reflux visits increased from 1998-2001 to 2002-2005 but then decreased in 2006-2009; percentage of reflux visits to otolaryngologists fell from 4.4% in 2002-2005 to 2.9% in 2006-2009. Approximately two-thirds of reflux visits were among internal medicine and family practice providers. Among the 3 study periods, number of reflux prescriptions increased 233% with continuing trends toward increased proton pump inhibitor and reduced H2 antagonist use.
Number of ambulatory visits for reflux continues to increase over time, across all demographic subgroups studied. Otolaryngologists are the only specialty who saw a decrease in overall reflux visits from 2002-2005 through 2006-2009; this may reflect real change in practice patterns, change in coding strategies or uncertainty in firmly establishing a reflux diagnosis. Understanding trends in this increasingly prevalent disease may focus attention on more precise diagnosis and improved treatment.
Evaluate the efficacy and safety of intranasal midazolam and syrup chloral hydrate for procedural sedation in children.
A prospective, randomized, double-blinded placebo controlled trial, in a tertiary care hospital over 18 months. A total of 82 children, ages 1 to 6 years, undergoing auditory brainstem response testing, were randomized to receive either midazolam nasal spray with oral placebo or syrup chloral hydrate with placebo nasal spray. Midazolam at 0.5 mg/kg delivered as 100 mcg per spray and oral syrup at a dose of 50 mg/kg. Children not sedated at 30 minutes had a second dose at half the initial dose. The primary outcomes measured were safety and efficacy. Secondary outcomes were time to onset of sedation, parental separation, nature of parental separation, parental satisfaction, audiologists satisfaction, time to recovery, and number of attempts.
There were 41 children in each group. No major adverse events noted. The chloral hydrate group showed earlier onset of sedation (66%) compared with midazolam group (33%). A significant difference in the time to recovery in the chloral hydrate (78 min) group compared with the midazolam group (108 min). Parental and audiologist satisfaction was higher for chloral hydrate (95 % and 75%) than for midazolam (49% and 29%). Overall, sedation with chloral hydrate was 95% compared with 51% with midazolam. Both the drugs maintained sedation.
Both intranasal midazolam and oral chloral hydrate are safe and efficacious for pediatric procedural sedation. Chloral hydrate was superior to intranasal midazolam with an earlier time to onset of sedation, a faster recovery, better parental and audiologist satisfaction, and successful sedation.
(1) Describe the treatment patterns for the management of severe epistaxis at a tertiary-care center. (2) Develop a clinical care pathway (CCP) for system-wide management of severe epistaxis.
A review of patients admitted for epistaxis from August 2012 to December 2013 was performed using: (1) CPT codes and (2) a digital archive of all medical records. Severe epistaxis was defined as persistent bleeding not controlled using local pressure, vasoconstrictive medication, and anterior packing. A root cause analysis identified factors contributing to the morbidity and mortality of patients with severe epistaxis.
Of 332 cases of epistaxis, 48 met criteria for severe epistaxis. Of these, 64.6% (31/48) presented via the Emergency Department and 35.4% (17/48) as an inpatient. All were packed initially. Average duration of packing was 3.02 ± 1.88 days. Nearly half (45.8%) failed packing and had either sphenopalatine artery ligation (37.5%) or embolization (8.3%). Intubation was required in 16.7% (8/48) for airway protection. Nearly half (48.9%) were inappropriately admitted to a location where key resources (operating room and interventional radiology) were unavailable after hours. A CCP was then devised in conjunction with emergency medicine that minimizes the duration of nasal packing and length of hospitalization and reduces the total cost of care. Implementation of the pathway required changes in the electronic medical record and educational programs.
Implementation of a CCP requires evaluation of current practices and the standard of care followed by input from institutional decision makers. Quantifying improvement requires retrospective normative data with ongoing review of compliance with the CCP.
Determine whether it is more cost beneficial to partake in a medical mission trip to developing countries to complete cleft repairs or to support medical professionals in providing local care.
Retrospective analysis of surgical costs per patient of different types of US-based charitable organizations. We compared financial information of 3 separate 501(c)(3)s for fiscal years 2011 and 2012. Cost per surgery was determined through expenses and total number of surgeries. Two organizations focus on service-based missions (typically US-trained surgeons and other clinicians traveling to developing countries to complete surgeries over a 1-2 week period). The third organization focuses on funding local surgeons (who are already trained and have proven expertise) to complete cleft repairs. This organization pays local clinicians to complete surgeries, and in return, surgeons upload results to an electronic medical record system so outcomes and progress can be tracked.
The cost per patient is significantly lower when local surgeons are paid to complete cleft repair cases than when entire teams of clinicians partake in service-based missions for cleft repairs. While different from country to country, the typical cost for locally provided care is as low as $250/patient. When relying on service-based missions, the average cost is above $500.
It is more cost beneficial to empower local surgeons in developing countries to complete cleft repairs.
The recurrent aphthous stomatitis (RAS) is a chronic oral inflammatory disease and it still poses as a clinical problem without satisfactory treatment. The aims of the study were: (1) Evaluate the clinical outcome of RAS patients towards the use of symbiotic Lactofos/Simbioflora, analyzing symptoms, seizure frequency, number, duration, and size of the lesions. (2) Compare the immune profile of RAS patients through cytokine levels with each other and controls before and after treatment.
We conducted double blind randomized clinical trial placebo controlled study with 60 patients with RAS and 30 controls in a period of 2 years (2011-2012).
The symbiotic group showed improvement in pain compared with placebo (
The symbiotic was effective in improving pain compared with placebo. Patients with RAS have a mixed profile of Th1/Th2 immune response when compared with the control group at baseline. The symbiotic induced Th1 and Th2 responses by increasing IL-12 and IFN-Y and IL-4 and IL-10, respectively.
(1) Describe the outcomes of early versus late tracheostomy in the critically ill patient population. (2) Apply these findings to the clinical setting when deciding on the timing of tracheostomy.
A systematic search was performed of the Medline, PubMed, and Embase databases, as well as the Cochrane Central Register of Controlled Trials. Randomized controlled studies investigating the outcomes of early versus late tracheostomies were included. The primary outcome of interest was the length of mechanical ventilation. Secondary outcomes include intensive care unit length of stay, incidence of pneumonia, and hospital mortality. The meta-analysis was completed using RevMan 5.2 (Cochrane Collaboration, Oxford).
The systematic search yielded 14 studies. There was no significant difference in the length of mechanical ventilation, with a weighted mean difference of –7.28 days (95% confidence interval [CI] –17.66 to 3.10). There was a significant decrease in the length of intensive care unit (ICU) stay with a weighted mean difference of –12.1 days (95% CI –21.7 to –2.52). The weighted risk ratio for pneumonia was 0.79 (95% CI 0.65 to 0.97) and for hospital mortality was 0.84 (95% CI 0.64 to 1.09).
Performing a tracheostomy within 8 days of intubation significantly decreased the length of ICU stay. It may also be associated with a modest decrease in the incidence of pneumonia. No difference was found in the length of mechanical ventilation or hospital mortality.
Identify factors that may be associated with lingual tonsil hypertrophy (LTH).
Retrospective chart review identified 380 patients from August 2013 to January 2014 with graded lingual tonsils, documented during routine flexible laryngoscopy. Lingual tonsils were graded using a 0 to 4 scale: 0 = complete absence of lymphoid tissue, 1 = lymphoid tissue scattered over tongue base, 2 = lymphoid tissue covers entirety of tongue base with limited thickness, 3 = lymphoid tissue 5 to 10 mm in thickness, 4 = lymphoid tissue >1 cm in thickness (above tip of epiglottis). Reflux symptom index (Reflux Symptom Index (RSI)–collected during patient intake), presence of obstructive sleep apnea (OSA; confirmed by polysomnogram), smoking habits, and basic demographics were gathered. Ï•2 and linear multi-variate regression analyses were used to identify significant correlating demographics with LTH.
Overall, 59.5% were male with a mean age of 50.2 ± 16.5 years and body mass index (BMI) of 30.1 ± 18.0. Ï•2 analysis revealed no significant relationship between OSA and LTH (
LTH does not seem to be associated with OSA in this group of patients. Abnormal RSI may be a factor associated with increased lingual tonsil thickness. Younger patients who smoke are more likely to have LTH.
(1) Analyze the evolving technique for gland-preserving transfacial removal of parotid stones including ultrasound, needle localization, and the combination of endoscopy with transfacial removal. (2) Review the success rate for patients treated with gland-preserving transfacial removal of parotid stones in an updated cohort.
Case series with chart review at a tertiary care university hospital from 2010 to 2014. Disease: Parotid sialolithiasis. Subjects: Patients with parotid sialolithiasis unmanageable with endoscopy alone. Intervention: Transfacial removal. Outcome measurements: Symptom relief, gland preservation, use of ultrasound, use of needle localization, stone size, stone location, facial nerve visualization, complications, and endoscopic confirmation of stone location prior to stone removal.
A total of 25 patients underwent transfacial operation for symptomatic parotid sialolithiasis. Ultrasound was used in 88% of cases and needle localization was used in 64% of cases. Sixteen out of 25 patients (64%) had completely successful therapy defined by no symptoms postoperatively with a preserved, functional gland. Ten of the remaining eleven patients without complete symptom resolution did endorse significant symptom improvement, while the final patient eventually underwent parotidectomy. Fifteen out of 25 patients (60%) had a stone that was localized with the endoscope prior to transfacial resection.
Transfacial removal of certain parotid stones is a functional alternative to parotidectomy for patients in whom endoscopy or shock wave therapy for stone retrieval is ineffective, unavailable, or contraindicated. Ultrasound and needle localization are useful adjuncts in stone retrieval.
(1) Implement the use of Google Glass in the operating room and in the office for teaching purposes and intraoperative consultations. (2) Recognize the potential for wearable technologies to maximally leverage the electronic medical record (EMR) as a platform to optimize communication between physicians and care for patients.
Google Glass is a wearable camera with an optical head mounted display (OHMD) with voice control and internet connectivity via either wireless or Bluetooth-smartphone tethering. The OHMD was used for procedures including tonsillectomy, endoscopic nasal polypectomy, office-based vocal cord injection, and flexible transnasal laser laryngoscopy.
The smartphone technology was used to successfully broadcast the surgical procedures to consultant surgeons off-site as well as mentor resident physicians during procedures. Procedures were performed without complications on patients under general anesthesia as well as patients under local anesthesia without sedation.
We report, to our knowledge, the first uses of Google Glass in head and neck surgery. This feasibility study will review potentials for Google Glass, including resident teaching and intraoperative consultations. We will address lessons learned thus far in optimizing the view obtained from the OHMD. We will also discuss implications of wearable technology in the hospital environment from the standpoint of the future of telemedicine, the consent process, and the potential for novel user interfaces with the EMR.
(1) Evaluate cricopharyngeal myotomy (CPM) for cricopharyngeal dysfunction (CPD) including Zenkers diverticulum (ZD) and cricopharyngeal bar/hypertrophy (CPB). (2) Analyze functional outcomes and quality of life associated with CPD following CPM.
A prospective multicenter study performed from January 1, 2012, to July 1, 2014, included patients presenting with CPD undergoing CPM. Standardized questionnaires including the 10-item Eating Assessment Tool (EAT-10), Functional Outcome of Swallowing Scale (FOSS), and the Reflux Symptom Index (RSI) were completed preoperatively, at 3 and 6 months postoperatively.
Thirty-two patients were included (18F; mean 71 years; range, 53-86 years). Primary CPD included ZD (17/32; 53.1%), CPB (6/32; 18.8%), and ZD+CPB (9/32; 28.1%). The most common comorbidities included GERD (11/32; 34.4%), hiatal hernia (6/32; 18.8%), and an underlying neurologic disease (5/32; 15.6%). Twenty-six patients (81.3%) underwent rigid-endoscopic, 3 (9.4%) underwent flexible-endoscopic, and 3 (9.4%) underwent open-transcervical CPM. One patient developed a leak on postoperative day 3. There were no deaths. Three patients experienced treatment failure at 7, 14, and 14 months postoperatively, requiring revision surgery. Mean preoperative RSI was 24.7 (range, 10-40), FOSS was 2.2 (range, 0-4), and EAT-10 was 20.7 (range, 2-34). The 3-month questionnaire (32/32, 100%) demonstrated an improved mean RSI of 7.2 (range, 0-30), FOSS of 0.6 (range, 0-3), and EAT-10 of 4.6 (range, 0-24). A total of 63% (20/32) completed the 6-month questionnaire, demonstrating a stable/improved mean RSI of 4.95 (range, 0-17), FOSS of 0.55 (range, 0-2), and EAT-10 of 3.1 (range, 0-15).
This represents one of the first prospective studies to demonstrate a significant improvement in functional outcome and quality of life in patients with CPD undergoing CPM.
Analyze the frequency of and techniques used in performing tracheostomies. Understand the prevailing contraindications used in the decision between open versus percutaneous method. Evaluate outcomes among the 2 modes of tracheostomy procedures.
Case-series review of all patients who underwent a tracheostomy spanning 4 years within a tertiary metropolitan hospital. Clinical and demographic data were used to compare the 2 groups of patients with respect to average age, hospital stay, related emergency department (ED) visits, and other complications.
A total of 1333 tracheostomies were performed on 1302 patients. This included 452 (34%) open versus 881 (66%) via the percutaneous dilatational technique (PDT). There was no difference in short-term complications between the 2 groups. The primary long-term complication, tracheal stenosis, occurred most commonly in the PDT group. The contraindications practiced in decision for open versus PDT are not uniform among the various services performing tracheostomies. Approximately 26% of all discharged patients presented to the ED with respiratory or tracheostomy-related complaint within 90 days of discharge.
We present the largest tracheostomy case-series containing a majority performed via the percutaneous technique. Tracheal stenosis is the most common long-term complication seen primarily among PDT group, indicating that factors such technique may lead to such outcomes. Institutional adoption of absolute contraindications may be necessary to avoid long-term complications. The development of an institutional common pathway for care and follow-up may help avoid related ED visits.
Different types of tympanostomy tubes (TT) are available to the otolaryngologist with relative advantages and disadvantages. The objectives of this study are: (1) Use a utility-based Markov Decision Analysis model to compare outcomes of short-term grommet tubes, “intermediate” type tubes (Triune, Grace Medical, USA), and “permanent” T-Tubes. (2) Use sensitivity analysis to determine the most important factors influencing outcomes with one type of TT versus another.
A Markov cohort decision analysis model was created using computer software (Treeage Software, Inc. USA) comparing the 3 types of TT. Published data were used to determine key baseline model parameters. The model featured potential complications including eardrum perforation, early TT extrusion, and the need for possible repeat TT placement after extrusion. Outcomes were quantified using a 0.95 (one procedure, full recovery) to 0.6 (failed myringoplasty) utility scale. Utility values were discounted over time to incorporate real life inconvenience. Statistical analysis included simple descriptive statistics and contingency tables.
The intermediate TT accumulated superior total utility in 2-, 4-, and 6-year models (2.48, 3.96, and 5.27 total utility) compared with grommets (2.32,3.82,5.18) and T-tubes (2.42, 3.86, 5.18). Examining a hypothetical 3000 child cohort, T-tubes resulted in an increased overall perforation rate (10.5% versus 2.0%,
The intermediate TT may produce favorable outcomes as it combines a balance of a lower perforation rate than T-tubes and a longer period of ventilation than grommet tubes.
(1) Determine incidence of HPV (human papillomavirus) infection in routine tonsillectomy swabs and specimens. (2) Determine if vaccination impacts tonsillar HPV infection.
This was a prospective study conducted from July 2012 to January 2014. Patients ages 1 to 100 years undergoing tonsillectomy for nonmalignant indications were enrolled. Demographic data and immunization status were collected. Specimens collected during surgery included a flocked swab and half of the left and right tonsil. All specimens were tested for HPV DNA using the polymerase chain reaction–based Roche Cobas Amplicor test and for the presence of E6/E7 mRNA using the Gen-Probe Aptima HPV test.
Patients were stratified into 2 groups, pediatric (ages 1-12 years) and adults (age 13 years and up) based on age of potential sexual maturity. In the pediatric group (n = 130) mean age was 5.2 years, 42% were female, 58% were male, and only 3 patients were fully vaccinated against HPV. In the adult group (n = 64) mean age was 24 years, 76% female, 24% male, and 47% were either fully or partially vaccinated. All specimens were negative for HPV infection via both testing methods. Internal controls confirmed the tests were functioning properly.
This is the first study to examine fresh tonsil swabs and tonsillectomy specimens for HPV infection using a Food and Drug Administration–approved method. Interestingly, both adult and pediatric specimens were negative for HPV infection. The role of vaccination in oropharyngeal HPV infection remains unclear.
Otolaryngology-related conditions make up 25% of primary care complaints; however, US medical schools do not routinely require otolaryngology instruction, potentially negatively impacting knowledge, attitudes, and medical student career choices. This survey was intended to (1) determine the extent of clinical and pre-clinical otolaryngology education at Accreditation Council for Graduate Medical Education institutions, and (2) focus future educational efforts.
A prospective online survey was sent from the Education Steering Committee of the American Academy of Otolaryngology—Head and Neck Surgery Foundation (AAO-HNSF) to all Accreditation Council for Graduate Medical Education (ACGME) otolaryngology training programs.
Forty percent (42/105) of program directors responded. They reported that medical students could graduate without any clinical instruction in otolaryngology in 85% (34/40) or any formal otolaryngology instruction in 59% (24/41). An otolaryngology rotation was required in only 5% (2/41) of programs. Increased exposure to otolaryngology was noted in 44% (18/41) while decreased exposure was seen in only 22% (9/41). Otolaryngologists provided formal teaching sessions for less than 8 hours over 4 years of medical school in 90% (26/29) of programs. When asked about instruction in specific topic areas, respondents did not know if topics were covered in 19-37% (8-15/42), regardless of topic.
Otolaryngology-provided education is extremely limited in ACGME medical student education despite its importance in patient care. We suggest that the lack of otolaryngology integration in the medical student curriculum should be the focus of future educational efforts, including a national medical student curriculum.
This study was conducted to identify the types of functional voltage-gated calcium channels expressed by the neuronal-like human parafollicular (CA77) cancer cell line.
CA77 cells were grown in culture and the expression of functional calcium channels studied using Fura-2 am during live cell imaging to measure changes in intracellular calcium levels in response to stimulation with potassium chloride (KCl) alone and in combination with several voltage-gated calcium channel blockers. These included: nifedipine, funnel spider toxin (FTX), and ω-conotoxin, which inhibit L-type, P/Q-type, and N-type voltage-gated calcium channels, respectively. To investigate transcriptional expression, primers for L-, N-, and P/Q-type channels were used in reverse transcriptase polymerase chain reaction (RT-PCR).
Significant increases in intracellular calcium levels were measured in response to KCl (
Taken together, our results provide evidence that CA77 cells express functional P/Q (CaV2.1) calcium channels, which are known to promote increased neuronal excitability, inflammation, and nociception. Thus, CA77 cells can provide an efficient and cost-effective means to screen novel therapeutics to treat migraine and other neurological diseases of the head and neck that involve P/Q channel activation in the underlying pathology.
Traditional rhinoendoscope is widely used in the diagnosis of a variety of nose diseases, but they can only be used by one doctor at a time. With the advances of electronic health technology, the extended potential application of smartphones to support medical practice is evolving. The first phase of the study discussed how smartphones can be used for rhinoscopic photography and image management via an innovative adaptor. The second phase of the study is to evaluate the diagnostic capability of the smartphone-based rhinoendcoscope compared with traditional video rhinoendoscope and its application in tele-otolaryngology.
We designed a unique adaptor to connect the rhinoendoscope and smartphone. The main idea is to transform the smartphone into a rhinoendoscope. The device uses the smartphone’s camera to capture rhinoscopic images. With an available free web real-time communication application platform and 3G (or WiFi) network, the smartphone-based rhinoendoscope could also synchronize your smartphone-based rhinoscopic image to other mobile devices.
Ten clinical rhinoscopic images acquired via the smartphone-based rhinoendoscope were tested in this study. Four teleconsultants reviewed the 10 clinical rhinoscopic images and made a telediagnosis. Compared with the face-to- face diagnosis, for which the diagnosis was made in person via traditional video rhinoendoscope, 4 teleconsultants obtained scores of correct primary telediagnosis of 90%, 90%, 100%, and 100%, respectively.
The use of already available technologies, without any additional expensive devices, could significantly increase quality diagnostics while lowering extra costs. It also increases connectivity between most isolated family doctors and remote referral centers.
(1) Review past literature on medical malpractice in rhinology and sinonasal disease in the Unites States of America. (2) Analyze otolaryngology malpractice litigation related to sinonasal disease in the last 10 years. (3) Discuss ways to prevent future malpractice litigation in this area of otolaryngology.
The study is a case series with review of court records pertaining to litigation of otolaryngologic treatment of sinonasal disease using the Westlaw and Lexis Nexis legal databases. The phrase medical malpractice was searched with terms related to sinonasal disease involving court cases in the last 10 years, yielding 26 cases. The cases were analyzed for pertinent data regarding plaintiffs, presenting complaint, practice setting, type of malpractice, resulting injury, result of verdict, and amount of reward or settlement.
Chronic sinusitis was the most common presenting symptom. Many cases included multiple types of alleged malpractice with the most common being negligent technique and lack of informed consent. The most common alleged injuries included cerebrospinal fluid leak, meningitis, nasal obstruction, and orbital trauma. Defendants prevailed in 13 of the 18 cases in which outcomes were known, with mean award of $225,000 and mean settlement of $212,500. The cases won by plaintiffs were all in a private practice setting.
Otolaryngologists should be aware of the causes of malpractice litigation as it relates to treatment of sinonasal disease and ensure informed consent is obtained and well-documented. A unified and complete database of medical malpractice cases is needed to allow for further analysis of specialty-related claims.
Arterial embolization has become a common treatment for intractable epistaxis. The objectives of this study are to evaluate the outcomes and optimal endovascular treatment strategy for patients undergoing embolization for intractable epistaxis.
Retrospective review of patients undergoing endovascular embolization for intractable epistaxis from 2004 to 2013. Patients having tumor embolization were excluded. Vessels were embolized with polyvinyl alcohol (PVA). Data were collected concerning demographics, risk factors, management prior to embolization, vessels embolized, outcomes, and complications.
Forty-three patients underwent embolization for intractable epistaxis. Risk factors included uncontrolled hypertension (n = 20), anticoagulation therapy (n = 17), facial trauma (n = 4), and recent nasal or palate surgery (n = 5). Therapy attempted prior to embolization included anterior nasal packing (86%), nasopharyngeal balloon packing (42%), chemical cauterization (9%), surgical intervention (19%), prior embolization (7%), and oropharyngeal packing (2%). Vessels embolized were bilateral maxillary arteries (MA) (81%), bilateral MA with bilateral facial arteries (5%), and unilateral MA when bilateral embolization was not possible due to vessel anatomy (14%). Successful embolization, defined as resolution of bleeding prior to discharge, occurred in 35 patients. Of the 8 cases with postembolization bleeding, 6 stopped spontaneously or with minimal intervention. The rate of successful embolization was 83% for both unilateral and bilateral MA embolization. The only major complication was nasal tip and alar necrosis that occurred in 1 patient after facial artery embolization. No neurologic complications were identified.
Maxillary artery embolization had favorable outcomes and no significant complications in the current study.
(1) Describe national trends in retropharyngeal abscess (RPA) complicating peritonsillar abscess (PTA). (2) Determine factors associated with RPA in patients with PTA.
Years 2003 to 2010 of the Nationwide Inpatient Sample (Healthcare Cost and Utilization Project, Agency for Healthcare Research and Quality) were queried for PTA (ICD-9 code: 475) and RPA (ICD-9 code: 478.24) in adult patients (age ≥18 years old). The cohort was analyzed using descriptive statistics and multivariate regression modeling to identify factors associated with RPA.
Of the 90,941 (95% confidence interval [CI]: 86,433-95,449) patients identified with PTA, 885 (1.0%) also had a concurrently coded RPA. The annual rate of concomitant RPA doubled (
The incidence of RPA among adult inpatients with PTA is increasing, and patients with RPA have higher in-hospital resource utilization. Further studies may help validate factors predictive of RPA to enable earlier identification.
(1) Retrospectively review esophageal foreign body (EFB) management. (2) Analyze the outcome of patients with EFB managed by either transnasal esophagoscopy (TNE) or rigid esophagoscopy. (3) Review the value of neck lateral view x-ray.
We retrospectively reviewed the cases suspicious for EFB managed between January 2007 and December 2013. In each case, neck lateral view was used for initial screening and the cases suspected to have EFB underwent esophagoscopy, which was rigid before July 2010, and TNE after July 2010.
From January 2007 to June 2010, 43 patients received rigid esophagoscopy and 31(72.1%) of them were positive for EFB. From July 2010 to December 2013, 302 patients underwent TNE. EFB was noted in only 52 patients and in 36 (69.2%) patients, the EFB could be removed by TNE, while in the other 16 patients with large, or sharp EFB, or possibly perforated esophagus, the EFB could only be removed by rigid esophagoscopy. In the 302 patients that underwent TNE, the sensitivity and specificity of true EFB by neck lateral view x-ray was 59% and 83%, respectively. There is no major complication of mediastinitis or esophageal perforation in both groups.
The introduction of TNE changes the diagnosis and management for EFB. TNE is a quick and safe office procedure under local anesthesia. Neck lateral view X-ray should not be a routine examination any more. TNE could replace neck lateral view X-ray to be the first screening procedure and also a useful treatment for patients with EFB.
The use of nonsteroidal anti-inflammatory drugs (NSAIDs) post-tonsillectomy is controversial, but recent severe complications associated with codeine and a resulting black box warning from the Food and Drug Administration have caused us to reassess their use. The aim of the study was to determine the efficacy of NSAIDs compared with other analgesics post-tonsillectomy.
We systematically searched Medline, EMBASE, the Cochrane trial registry, and Web of Science. Only randomized controlled trials (RCTs) that compared an NSAID with either placebo or non-NSAID active comparators were included. Studies had to measure a pain-related outcome (eg, total morphine used, pain scores). Secondary outcomes included differences in vomiting, bleeding, admission to the hospital, and return to emergency department. We did not discriminate for age of patients. RevMan 5.0 was used to synthesize and analyze the data extracted from studies reviewed.
Based on the meta-analysis of the data retrieved from 60 articles, NSAIDs were found to be equivalent to other active comparators in the early postoperative period. There was also significantly less vomiting in the NSAID group. Small sample sizes of studies and heterogeneity of methods for reporting pain restricted the sample size for comparison of outcomes.
NSAIDs are as effective as active comparators for pain relief. We recommend a large RCT to confirm these findings.
(1) Describe treatment of the heterogeneous disorder of laryngopharyngeal reflux (LPR) with a new upper esophageal sphincter (UES) assist medical device designed to eliminate the reflux of gastric contents into the laryngopharynx. (2) Analyze the reduction of symptoms pre-therapy compared to posttherapy.
Patients presenting with a reflux symptoms index (RSI) >13 and diagnosed with chronic cough, postnasal drip, globus, or throat clearing were included in the study. The UES assist device was fitted individually to apply external pressure above 20 mm Hg at the cricoid and worn when sleeping. The primary effectiveness endpoint was reduction of the RSI at 4 weeks. SF-36 Health Survey, Functional Outcomes of Sleep Questionnaire (FOSQ), and patient and physician satisfaction scores were secondary end points. Intent to treat (ITT) analysis was performed. Safety was based on reported adverse reactions.
Forty-four patients consented, with 42 (ITT) completing the study (age, 47 ± 13.1 years; body mass index, 24.8 ± 3.5; 66% female; 75% Caucasian). Most troublesome symptoms were post nasal drip, throat clearing, and annoying cough. Adverse events were mild and short in duration with no study withdrawals due to an adverse event. There was a significant (
The UES assist device is a safe and effective noninvasive method for the treatment of LPR and provides clinical utility within 2 weeks. This could be a potential alternative for LPR before considering medications or surgery.
Study head and neck gunshot wounds (GSW) involving pediatric patients in the United States.
Study Design: Retrospective cohort study. Setting: The KIDS Inpatient Database (KID) years 2003, 2006, and 2009. The subpopulation of pediatric patients 21 years and younger admitted with head and neck trauma due to gunshot wounds were compared with all patients admitted with head and neck traumatic injuries. Univariate and multivariate analysis was completed to evaluate demographics, morbidity, and mortality associated with gunshot wounds to the head and neck. Age, sex, and ethnic disparities were also examined.
An estimated 1342 (SE, 100.7) pediatric patients suffered gun shot wounds to the head and neck, 3.2% (SE, 0.19) of all head and neck traumatic wounds. The mean age was 17.1 years (SE 0.12). The population was 88.1 % male (SE, 1.1), 48.2% (SE, 2.9) black, and 10.2% (SE, 1.1) died during their hospitalization. Mean total charges were $70,312 (SE, $4216). When compared with the larger population of pediatric head and neck trauma patients, GSW patients were statistically significantly older, male, black, and living in the lowest income quartile (all
Gunshot wounds to the head and neck are an uncommon but serious injury in pediatric patients. Continued research regarding treatment and prevention is warranted.
(1) Assess otolaryngology–head and neck subspecialist utilization within a large telemedicine program. (2) Examine the impact of that program on graduate medical education.
A retrospective review of the Pacific Island Health Care Project records from 1998 to 2012 was performed to identify the number and type of telehealth consultations for patients with disorders of the head and neck. Consultations were categorized into diagnostic groups to evaluate referral patterns. Medical records from patients referred through the program were reviewed to determine the number and types of surgical procedures performed.
Four thousand telehealth consultations were sent to a single medical center with consultants representing all major medical and surgical subspecialties. A total of 730 teleconsultations were submitted for primary disorders of the head/neck, representing 18.3% of all consultations. The 3 most common reasons for teleconsultation included: benign or malignant head/neck mass (nonthyroid); thyroid mass; and cleft lip/palate. A total of 242 patients were referred for definitive surgical management. Seven hundred fifty-eight coded procedures were performed on those patients resulting in 383 key index procedures.
Otolaryngology as a specialty is well suited for telemedicine applications. This study demonstrates a high utilization of otolaryngology indicating a high degree of referral feasibility and a high requirement for head and neck specialist consultation. This program had a large impact on graduate medical education, not only in terms of increased experience with complex patient care and operative case numbers, but also less tangible benefits relating to opportunities for residents to develop key competencies required for successful graduate medical training.
Assess postoperative pain of the thermal welding system tonsillectomy compared to conventional tonsillectomy.
A total of 342 patients aged from 8 through 39 years were enrolled in a randomized prospective controlled study. Extracapsular tonsillectomy with thermal welding and conventional system was performed randomly in each patient. Patients with chronic tonsillitis were included. Patients undergoing adenoidectomy, with suspected or confirmed tonsillar malignancy, or undergoing another procedure together with tonsillectomy were excluded from the study. Postoperative pain was measured by means of Face Pain Scale and Numerical Pain Score for each patient on 3 occasions (6-8 hours postoperative, 24 hours postoperative, and 6 days later during the first postoperative visit) for each side.
There was a statistically significant difference between the pain scores of both procedures on all 3 occasions (
Thermal welding tonsillectomy is superior to the conventional technique, with less postoperative pain.
(1) Investigate the utility of residency applicant characteristics as predictors of technical skill. (2) Demonstrate the feasibility of technical skill assessment in the residency interview setting.
A cross-sectional study was performed in December of 2013 to identify residency applicant characteristics that may predict technical skill. During 2 residency interview days, 39 medical students performed up to 5 trials each of 2 box trainer tasks: myringotomy and endoscopic grasping. Subject performance was assessed by an attending surgeon using a global rating scale (GRS). Completion time and error counts were recorded. Applicant factors studied were United States Medical Licensing Examination Step 1 score, Alpha Omega Alpha status, medical school grades, and extracurricular activities. Pearson coefficients and Wilcoxon rank-sum tests were used to evaluate each applicant characteristic.
A total of 117 endoscopic grasping trials and 179 myringotomy trials were assessed. Thirty-eight of 39 subjects completed both tasks at least 3 times. Participation in competitive sports was associated with more errors during the first endoscopic grasping trial (W = 110.5,
Common methods of residency applicant assessment do not predict performance on otolaryngology-specific task trainers. It is feasible to measure initial technical skill acquisition in the residency interview setting. It is unknown whether initial technical skill acquisition will correlate with technical skill during residency.
(1) Identify factors that may predict the quality of economic evaluations in the otolaryngology literature. (2) Identify current weaknesses in published economic evaluations for the purposes of improving the quality of future studies.
This is a retrospective quality review of published economic evaluations using the validated Quality of Health Economic Studies (QHES) instrument. A systematic review of the Medline, Embase, PubMed, and NHS economic evaluation databases was performed using otolaryngology key terms combined with the terms cost and effectiveness. A manual search of 33 otolaryngology journals was also performed to prevent missed studies. Included studies were graded using the QHES instrument, a 16-item checklist providing a total quality score of 100.
Fifty studies were identified, and the mean QHES rating was 54.7 (SD: 31.0). Higher quality economic evaluations were associated with a higher journal impact factor (correlation coefficient
The quality of economic evaluations is important to properly inform efficient allocation of scarce health care resources. Our study investigated the overall quality of economic evaluations in the otolaryngology literature and demonstrated that there is potential to improve the quality of published studies. Future studies should follow published methodology guidelines and consider collaborating with authors who have experience with economic evaluation.
(1) Identify high-risk symptoms and anatomical regions involved in Angiotensin Converting-Enzyme Inhibitor-Induced Angioedema (AIIA) that may affect admission and placement, hospital length of stay, need for airway intervention, and clinical improvement versus deterioration. (2) Describe a clinical algorithm for the management and treatment of AIIA that would dictate placement of patients (ICU, general medical floor, observation unit, or discharge home), medical therapy, and the need for airway intervention (intubation or tracheostomy).
A retrospective chart review of adult patients presenting to the emergency department (ED) at Detroit Medical Center diagnosed with AIIA from July 2010 to July 2013. Patients were followed from initial presentation until discharge. Descriptive statistics (frequency, means, and standard deviations) were calculated for all predictor, outcome, and control variables.
A total of 302 patients who were diagnosed with AIIA in the ED were evaluated with flexible laryngoscopy by an otolaryngologist. A total of 94% of patients were African American, with a slight female predominance of 63%. The most frequent presenting sign was lip swelling (62%). Angioedema confined to the lips was a negative predictor for airway intervention (
This is the largest patient series to date of AIIA. Using the information from this study, a clinical algorithm was developed that details management of AIIA based on presenting signs and anatomic location, with otolaryngologists playing a vital role in the decision making process.
(1) Determine whether there is a difference in the incidence of human papillomavirus (HPV)–associated oropharyngeal carcinoma (OPC) between non-Hispanic Caucasians and minorities in an institutional series drawn from the highly urbanized population of New York City.
Several recent studies suggest that rates of HPV-associated OPC are higher in Caucasians than in minorities. We hypothesized that this difference would be lower in the highly diverse, urban population of New York City. This is a retrospective chart review of 240 patients with surgically treated OPC at the Icahn School of Medicine at Mount Sinai (ISMMS) between 1999 to 2013. Researchers determined age, sex, race, ethnicity, and tumor site of study participants. Polymerase chain reaction (PCR) was used to detect the presence of oncogenic HPV-DNA in paraffin tumor blocks. Incidence of HPV-positive cancers was compared between Caucasians and minorities (defined as African Americans, Asians, and Hispanics) using Fisher’s exact test.
We found a higher incidence of HPV-positive OPC HPV in Caucasians than racial minorities within the ISMMS population (
The incidence of HPV-positive OPC is higher in non-Hispanic Caucasians than in minorities in New York City. This observation is consistent with previously reported trends from study populations in less urbanized areas.
Patients with angioedema present to the emergency department (ED) with myriad signs and symptoms with a wide range of severity, from mild discomfort to severe airway compromise. Initial estimation of angioedema course and patient airway safety can be challenging. Base of tongue (BOT) and laryngeal involvement are recognized to correlate with need for intubation; however, there are few clear indicators of potential future airway compromise. We evaluated the relationship between presenting signs and symptoms with fiberoptic laryngoscopic findings to help in the immediate stratification of angioedema patients.
Retrospective chart review of patients presenting with angioedema to the ED of a tertiary care center from January 2005 to July 2013.
Of 1987 patients treated by the ED for angioedema, 401 generated an otolaryngology consult; of these, 79 (19.7%) and 128 (31.9%) had base of tongue (BOT) and laryngeal involvement, respectively. Dysphagia and voice change correlated with both BOT and laryngeal edema (
Patient report of dysphagia, voice change, sensation of throat closure along with tongue, floor of mouth, uvular, or neck swelling on initial presentation should raise suspicion of compromising BOT or laryngeal involvement. This cohort of patients requires a higher index of suspicion for potential airway intervention.
(1) Determine simulation resources available within United States otolaryngology training institutions. (2) Determine current involvement in simulation within otolaryngology training programs. (3) Gauge interest in advancing simulation for training and assessment.
A voluntary survey was sent to 104 program directors. The introduction provided a broad definition of simulation. Responses were collected between March 21 and April 5, 2013. Descriptive results are presented.
Responses were received for 43 (41%) of the surveys. A total of 39 of 43 respondents (91%) have a simulation center or program at their institution. A total of 34 of 43 respondents (79%) have onsite simulation, 32 (74%) have models, manikins, or other devices, and 25 (58%) have staff resources within their institution. A total of 8 of 43 respondents (19%) have extensive, 26 (60%) have limited, and 8 (19%) have no otolaryngology simulation activity at their institution. The most common applications of simulation within otolaryngology are emergency management (23 of 43 respondents; 53%) and otology (21 of 43; 49%). All 31 respondents use simulation for clinical training (100%), 11 (33%) for proficiency, and 7 for mastery (21%). Three of 36 (22%) use extensive, 12 (33%) limited, and 21 (58%) no simulation in research. None of 34 use simulation for otolaryngology credentialing, although 2 (6%) use simulation for advanced cardiac life support credentialing. A total of 31 of 37 respondents (84%) are interested in participating in multicenter trials of simulation initiatives.
Simulation resources are widely available in otolaryngology training institutions. Survey respondents report limited but widespread participation in simulation activity, and widespread interest in participating in simulation trials.
Comparisons between studies involving the tongue base are limited by the lack of a universal system for grading lingual tonsils. The authors propose a new standardized grading system for lingual tonsil hypertrophy (LTH). Validation was assessed via an interexaminer agreement study.
Video assessment: The proposed grading system consists of a 0 to 4 scale with: 0 = complete absence of lymphoid tissue, 1 = lymphoid tissue scattered over tongue base, 2 = lymphoid tissue covering entirety of the tongue base with limited vertical thickness, 3 = lymphoid tissue 5 to 10 mm in thickness, 4 = lymphoid tissue >1 cm in thickness (above tip of the epiglottis). A teaching video was created to demonstrate identification of this grading system. After viewing the teaching video, 8 trained otolaryngologists graded 25 video clips of the tongue base, recorded during flexible laryngoscopy. Live assessment: A second study was performed by 2 examiners directly examining the tongue base of 23 patients using flexible laryngoscopy during a routine clinic visit. Each examiner viewed and recorded the grade of the lingual tonsils independently.
Video assessment: The overall Fleiss kappa statistic was found to be κ = 0.449 (
The moderate interexaminer correlation demonstrated during video-assessment, and perfect interexaminer correlation demonstrated during live assessment, indicate that this proposed grading system may be a valuable and useful tool in creating a common language to describe lingual tonsils.
(1) Create a protocol for developing educational videos for patients of all health literacy levels. (2) Describe National Institutes of Health (NIH) guidelines, evidence-based principles of instructional design, and industry best practices related to creating educational videos for patients.
Utilizing (1) NIH guidelines for patient education materials, (2) evidence-based principles of instructional design, and (3) industry best practices, a 10-step protocol was developed for creating video-based patient education materials. As a proof-of-concept, these 10 steps were used to create a short video to help patients understand flexible laryngostroboscopy.
Using NIH guidelines, a script was created with text designed for the sixth-grade reading level using the SMOG Readability Formula. Evidence-based principles of instructional design that were incorporated into the video included: the Personalization Principle, Multimedia Principle, Coherence Principle, Contiguity Principle, and Practice Principle. A video was recorded with a high definition camera, and audio narration was recorded separately. A short video describing laryngeal anatomy and showing actual footage laryngostoboscopy was edited on Camtasia Studio 8.0 and produced for optimized viewing on the iPad. The video was pilot tested on patients prior to undergoing flexible laryngostroboscopy at an outpatient otolaryngology–head and neck surgery clinic.
There is currently no protocol for creating educational videos for patients with limited health literacy. This 10-step protocol was created to help those creating educational videos incorporate NIH guidelines, evidence-based principles of instructional design, and industry best practices into their projects.
Comparing management of tracheotomies in older (>75 years old) versus younger patients ≤75 years old) for duration of hospitalization secondary to tracheotomy and finding associated risk factors.
Retrospective chart review (2003-2013) for all patients >75 years old who had tracheotomy compared to patients ≤75 years old.
Mean age is 79.3 versus 53.1 years, respectively (
Elderly patients need special management secondary to a tracheotomy to prevent prolonged hospitalization. Improving doctor awareness and knowledge of patient risk factors may improve tracheotomy management.
Human papillomavirus (HPV)–related head and neck squamous cell carcinoma (HNSCC) is extensively studied in the developed world but relatively less studied in developing countries. The goal of this review is to determine the state of knowledge of HPV-related HNSCC in Latin American countries (LACs) and to highlight areas that would benefit from additional research.
Databases searched included PubMed and Virtual health library (LILAC). All Latin American studies addressing HPV-related HNSCC of oral cavity, oropharynx, and larynx were selected. We did not restrict studies by type of study, sample size, or method of HPV detection; however, case reports were excluded. Each article was reviewed for incidence/prevalence of HPV-positive HNSCC, demographics, social history, and clinical outcomes.
Thirty-eight full-text articles were reviewed that identified HPV-positivity in 33%, HPV 16 being most prevalent. Twenty-three of 38 (60%) had a sample size <50, and a HPV-negative control group was described in only 8 out of 38 (21%) articles. Oral cavity rather than oropharynx was mostly studied, with “tongue” the most commonly involved site, raising concerns for misclassification of site between oral cavity and oropharynx. Sexual history, the most significant risk factor for HPV, was addressed in only 2 out of 38 articles. Prognosis/survival was addressed in 8 out of 38 articles, and only 2 articles described better survival outcomes in HPV-positive cases.
Future research on HPV in LACs should emphasize consistent classification of tumor topography, larger sample sizes, and comparison with HPV-negative control groups. The role of sexual history/behavior and better prognosis of HPV-positive tumors are critical observations in the developing world that require further investigation in LACs.
(1) Determine the construct validity and the reliability of video assessment scoring of myringotomy and grommet insertion. (2) Measure the performance (by rating) of participants compared to operative time.
Study design was a single blinded (raters) video assessment, conducted in a tertiary care university hospital August to October 2013. Participants were consultant and trainee (Specialty Registrar [StR] and Core Trainee [CT]) ear, nose, and throat (ENT) surgeons performing a total of 30 consecutive index procedures. Two raters at ENT Consultant level with a subspecialty interest in otology who did not take part in the study were invited to score results.
A strong correlation between scores by the 2 blinded raters was demonstrated (rho = 0.748;
Video assessment of this procedure may represent a valid, feasible tool for use in summative and formative assessments of trainee ENT surgeons. Remote scoring of assessment procedures minimizes bias and enables blinding of raters.
Tonsillotomy has been presented as a less-invasive alternative to the traditional tonsillectomy. The decreased pain and recovery time after tonsillotomy have been well established, but questions regarding tonsil regrowth remain. It has been assumed that parents would prefer tonsillotomy because of its recovery advantages. The objective of this study is to (1) directly sample the opinion of typical parents who would be considering tonsillotomy versus tonsillectomy. (2) Assess the role of age, educational level, and risk aversion in this parental choice.
Parents in a busy pediatric otolaryngology waiting room were approached and asked to hypothetically choose either tonsillectomy or tonsillotomy for their child via a written survey. Each procedure was described in basic terms listing basic risks and benefits including pain, recovery, regrowth, and incidence of complications. Parents were also asked simple questions regarding age range, educational level, and risk tolerance. Data analysis included simple descriptive statistics and contingency table analysis.
Two hundred thirty parents completed the survey. Parents overwhelmingly (85.8%) preferred tonsillectomy over tonsillotomy. An increasing risk aversion score was associated with a preference for tonsillectomy (
Despite prevailing opinion that presumes parents generally prefer tonsillotomy over tonsillectomy because of its recovery advantages, an overwhelming majority of parents surveyed actually prefer tonsillectomy. The basis of this decision appears to be in part risk aversion of tonsil regrowth.
(1) Determine complication rates of Triune tubes. (2) Compare complication rates of the Triune tubes with rates cited previously in the literature. (3) Compare complication rates of Triune tubes with T-tubes and grommet tubes.
A retrospective chart review was conducted on myringotomy tubes placed from 2002 to 2011 by a single surgeon in a university hospital setting. Medical records were reviewed for the following data: type of myringotomy tube placed, duration of time the tube remained situated in the tympanic membrane, complications related to the tube placement (persistent tympanic membrane perforation, tube obstruction, granuloma formation, or reoperation), and procedures performed to remediate any encountered complications.
A total of 1216 tubes were placed in 565 patients (250 female). Average patient age was 6.8 years (range, 3.7 months to 95.6 years). The primary indication for myringotomy with tube placement was chronic serous otitis media (n = 1062, 87.2%). Other indications included recurrent acute otitis media (n = 12, 1.0%), removal and replacement of nonfunctioning tubes (n = 132, 10.8%), and barotrauma (n = 11, 0.9%). The indication was not specified for 1 tube (0.1%). During the study period, 459 (37.7%) of the tubes placed were Triune, 650 (53.5%) were T-tubes, 88 (7.2%) were grommets, and 19 (1.6%) were not specified. Overall, complications occurred in 96 (20.9%) Triune tubes, 134 (20.6%) T-tubes, and 9 (10.2%) grommet tubes. However, these differences were not statistically significant (chi-square 4.797;
Triune tubes are safe when myringotomy tube placement is indicated. Complication rates with Triune tubes are comparable with both grommet tubes and T-tubes.
The US Air Force (USAF) enrolls 1400 Specialized Undergraduate Pilot Trainees (SUPT) at 3 locations within the United States each year. SUPT training has an estimated accumulated cost of $1M to $1.5M per trainee. Attrition rates from training have ranged from 7.8% to 36.9%. The cost associated with trainee disqualification is estimated at $1M per percentage point of annual attrition. One percent of UPT disqualifications are due to medical factors and another 1.5% are due to failure to adapt to flying.
In 1994 the USAF conducted rotary chair vestibulo-ocular (VOR) test on 150 SUPT candidates at the USAF Research Laboratory, Brooks Air Force Base as part of the second phase of the Enhanced Flight Screening- Medical Study (EFS-M). Retrospective review of SUPT scores was correlated with pre-training VOR test results of the original 150 pilots who participated in the EFS-M VOR data collection. Twenty-year prospective survey data collected from EFS-M study pilots was correlated to initial EFS-M VOR test results to identify trends in their subsequent pilot career progression and incidence of in-flight physiologic events deemed linked to vestibular illusions.
VOR performance trends exist between USAF pilot trainee cohorts. VOR performance can predict initial flight training proficiency in SUPT candidates. Long term follow-up survey responses indicate that VOR performance can predict flight career proficiency in SUPT training candidates.
A validated correlation between VOR results and flight performance can help establish VOR test parameters associated with successful flight training ability.
Assess advantages and disadvantages of 3-dimensional endoscopy in the transnasal approach to sellar region, posterior skull base, and cervical junction.
Between January 2012 and December 2013, 87 patients were consecutively treated at the Neurosurgery Division of the University of Turin for sellar, skull base, and cervical junction pathologies. All procedures were performed by the same team (2 ENT surgeons and 2 neurosurgeons) using a 3-dimensional (3D) stereoendoscope (VSII system, Visionsense Ltd, Petach Tikva, Israel). After each procedure each surgeon was asked to fill out a questionnaire (based on visual analogue scales) designed to assess comfort and learning curve.
Seventy patients were treated for pituitary macroadenomas, 10 for chordomas, 6 for a malformation of the cervical junction, and 1 for a chondrosarcoma of the odontoid process of C2. A cerebrospinal fluid (CSF) leak was observed in 6 out of 70 patients, 1 out of 10 patients, and 0 out of 7 patients, respectively; 5 out of 7 CSF leaks were intraoperatively solved and 2 out of 7 required revision surgery. No vascular complications were recorded. Median global comfort score (sensation of strain + dizziness + system ergonomics scores), recorded at the end of the first and second procedure, was 9.1 and 9.6, respectively; after the third procedure it reached 10. The learning curve score reached the maximum level of 9.5 after the eighth procedure.
3D stereoscopic vision system is comfortable for the surgeons allowing them to have a better visualization of anatomic structures and landmarks; it is easy to use and after only a few procedures surgeon skills reach high levels.
(1) Determine the trend of the number of tracheotomies performed by otolaryngologists. (2) Determine the changes in surgical technique over time.
A retrospective chart review of all patients undergoing tracheotomy between 1999 and 2013 was performed at a large tertiary care hospital. Data were gathered from billing and operative reports to determine the specialty service performing the tracheotomy. Additionally, the surgical technique and indication for surgery were recorded. Negative binomial regressions (extension of Poisson regression to account for over dispersion) were conducted to examine number of tracheotomies for each specialty as function of year.
In 1999, 46.55% of tracheotomies were being performed by the otolaryngology service, compared with only 28% in 2013. This is a decline of 21.55% over time. Since 1999, general surgery has a steady increase in number of tracheotomies performed in comparison to the steady decrease performed by otolaryngology. Since 2008 general surgeons have significantly increased the number of percutaneous tracheotomies they perform (76%/year). Over the same period, the number of tracheostomies performed by the cardiothoracic (CT) surgery service has steadily increased by 26% per year. Most of the tracheotomies performed by CT surgery are percutaneous tracheotomies.
This study illustrates that otolaryngologists in our institution are performing fewer tracheotomies over time. If this trend continues, the experience of our trainees may become diluted through reduction in surgical volume. While multi-institutional studies are warranted, this review provides a summary of the trend at a tertiary care institution which may well reflect national trends.
(1) Review the rate of postoperative hypocalcemia in patients undergoing thyroidectomy in the summer and winter. (2) Identify the association between the season when surgery was completed and the risk of postoperative hypocalcemia.
A retrospective chart review of 436 patients undergoing thyroidectomy at the McGill University Thyroid Cancer Centre from 2006 to 2014 was performed. Patients undergoing total or completion thyroidectomy in the winter months (December to February) and summer months (July to September) were included in the study. Parathyroid hormone (PTH) and serum corrected calcium were recorded according to the McGill post-thyroidectomy protocol. Preoperative PTH and 25-hydroxyvitamin D (25-OHD) were measured. Hypocalcemia was defined as a corrected calcium level <1.9 mmol/L.
The rate of postoperative hypocalcemia was 8% for patients operated on in the winter and 1.8% for those in the summer (
In this study, patients undergoing thyroidectomy during the winter months were 4.3 times more likely to develop postoperative hypocalcemia when compared with patients operated in the summer.
Determine the outcome and cause of negligence claims relating to thyroid surgery in the National Health Service (NHS).
A request was submitted to the NHS Litigation Authority for claims relating to thyroid surgery between 1995 and 2013 by searching for the key words: “thyroid,” “endocrine,” or “neck.” Claims were analyzed for cause of injury, type of injury, outcome of claim, and costs.
Of 132 cases, 90% were closed with 55% of closed claims leading to payment of damages and 72% of closed claims leading to payment of any sort (including settlement out of court). Fifty-two percent of claims were related to complications of surgery with the rest being related to errors in diagnosis and treatment. Lack of informed consent was claimed in 11 cases. The most common injuries claimed were vocal cord dysfunction (n = 28) followed by endocrine disturbance such as hypocalcemia or hypothyroidism (n = 20). Eight fatalities occurred, of which 7 were due to hematoma and one was due to hypocalcemia. The highest payment was £945,700 ($1,585,000) for bilateral vocal cord paresis requiring a permanent tracheostomy. The median payment per claim was £21,390 ($35,850).
Thyroidectomy-related claims in the National Health Service are rare but have a high success rate. Negligence from operator error correlates well with known complications of thyroid surgery. However, a significant proportion of claims are not related to surgery and represent areas where good care should be addressed by a multidisciplinary approach to the management of thyroid pathology.
(1) Identify antibiotic practice patterns for laryngectomy. (2) Determine the clinical and cost outcomes associated with antibiotic management strategies.
University HealthSystem Consortium inpatient billing data on patients undergoing laryngectomy in 2008 to 2011 for 95 academic and affiliated medical centers were analyzed for antibiotic use, outcomes, and cost.
Data from 1912 patients (18.1% women) were included in the study. Antibiotic management over the first 72 hours revealed 458 unique management strategies. Antibiotic choice had a significant association with rate of surgical site infection (SSI), with standard regimens of ampicillin/sulbactam (1.4%) or cefazolin+metronidazole (4.3%) having lower rates compared to clindamycin (11.8%;
There is substantial variability in perioperative antibiotic strategies for laryngectomy. Clindamycin had a much higher rate of SSI compared with other common regimens and was associated with a higher total hospital cost. Based on this data, standardization of antibiotic practices should be considered and clinical trials should be planned to firmly establish the most cost-effective antibiotic management for laryngectomy and determine potential alternatives to clindamycin for penicillin-allergic patients.
Prior work identified differences in survival by treatment type for localized laryngeal squamous cell carcinoma (LSCC) in the Surveillance Epidemiology and End Results (SEER) registries. We sought to determine whether these differences were attributable to sociodemographic, clinical, and treatment facility characteristics in the elderly.
The SEER-Medicare linked files (1991-2009) identified patients (ages 66+ years) with T1 LSCC. Logistic regression models were constructed to identify sociodemographic characteristics associated with treatment type. Kaplan-Meier methods were used to examine the association of treatment type and survival. Cox proportional hazards modeling was used to assess the impact of potentially important factors such as sociodemographic, clinical, or facility characteristics.
We identified 1369 patients with T1 LSSC. Radiation alone was the most common treatment. Treatment with local surgery ± radiation was associated with slightly better survival than treatment with radiation alone in our unadjusted Kaplan Meier model. Adjusted for comorbidity, treatment with both local surgery and radiation was associated with greater survival (
Previously observed differences in survival across single modality treatment types for T1 LSSC in the elderly may be partially attributable to medical comorbidity, but treatment with both surgery and radiation was associated with improved survival independent of comorbidity. Other patient and facility characteristics showed no appreciable impact on survival after treatment of T1 LSSC in this population.
Assess public awareness of human papillomavirus (HPV) as a cause of oropharyngeal cancer.
A total of 477 participants were randomly chosen to participate in a 23-item survey at various shopping malls and Maxwell Air Force Base in 2012. The Chi-square test was used in statistical analysis.
Three hundred nineteen participants were civilians and 158 were military officer trainees (MOT). All MOT had a bachelor’s degree or higher, while 37% of civilian participants had a bachelor’s degree or higher. Eighty-two percent of MOT knew of oropharyngeal cancer, but 53% of civilians had not heard of oropharyngeal cancer (
Most people were aware that HPV is a causative agent of cervical cancer. However, the majority were not aware of the association between oropharyngeal cancer and HPV. Furthermore, many participants were not aware that HPV equally affects men and women and that the vaccine is available for both sexes. This underscores the need to educate the public on the availability of HPV vaccine and the association between HPV and oropharyngeal cancer.
The role of elective parotidectomy and the extent of surgery for occult nodal metastasis in cutaneous squamous cell carcinoma (SCC) is controversial. We wanted to determine if the MEK/ERK pathway and pathologic features in the tumor could predict skin cancer aggressiveness and allow for preemptive treatment of occult metastasis.
Retrospective experimental laboratory study and chart review. Specimens from basal cell carcinoma (BCC; n = 13), squamous cell carcinoma (SCC; N = 10), and SCC with parotid metastasis (n = 11) were analyzed by immunohistochemistry (IHC) for pERK (Thr202/Tyr204) and pS6 (Ser235/236) and scored by the study pathologist. Simple logistic regression analysis evaluated all subjects with previous resection of cSCC and parotidectomy (n = 13) for independent risk factors of disease aggressiveness.
Expression of pS6 increased in cSCC with parotid metastasis (
Positive margins on primary skin lesions, perineural involvement of parotid specimens, and Biomarker pS6 appear to be predictors of aggressiveness in cSCC and should prompt increased monitoring or elective treatment. As pERK was not significantly activated, pS6 overexpression could indicate activation of the Akt/mTOR pathway.
Immunosuppressive immunocytes induced by cancer-associated inflammation, such as myeloid derived suppressor cells (MDSC) and T-regulatory cells (Treg), mediate immune-escape critical to development of solid tumors, including melanoma and oral squamous cell carcinoma (OSCC). Novel therapeutic approaches, which block tumor-mediated immunosuppression, unmasking endogenous anti-tumor immune responses, are thus a rational treatment approach. The aims of the study were: (1) Demonstrate that inhibition of inducible nitric oxide synthase (iNOS, critical for MDSC development) and Treg depletion in preclinical cancer models leads to potent anti-tumor activity; (2) Design a regimen suitable for testing in clinical trials.
Mouse bone marrow cells were co-cultured with MT-RET melanoma supernatants ex vivo to generate MDSC in the presence of doxycycline, an iNOS inhibitor. C57/BL6 wild-type mice were injected with syngeneic MT-RET-1 melanoma. Tumor-bearing mice were treated with injection(s) of cyclophosphamide and/or doxycycline. Tumor growth and survival times were measured, and tumors and spleens harvested for CD8+ T-cell and other immunocyte levels.
In co-cultures, induction of MDSC was significantly reduced in the presence of doxycycline. Treatment of MT-RET melanoma-bearing C57/B16 mice with doxycycline resulted in tumor-infiltrating CD8+ T cells enhancement and tumor growth suppression. Treatment with cyclophosphamide suppressed intratumoral Treg accumulation. Dual treatment with cyclophosphamide and doxycycline suppressed tumor growth more efficiently than either alone.
Treatment with the immunomodulators doxycycline and cyclophosphamide is a promising approach to reversing tumor-mediated immunosuppression and suppressing cancer growth in solid tumors, like melanoma and OSCC. Thus, we have designed a window of opportunity clinical trial of doxycycline and cyclophosphamide before surgical resection of OSCC.
(1) Evaluate the role of p16 status of cervical lymph node (LN) metastases in localizing carcinoma of unknown primary (CUP). (2) Compare the sensitivity, specificity, and accuracy of positron emission tomography PET scan for locating the primary site in the setting of p16 positive and p16 negative LN metastases.
Retrospective review of 30 patients that were identified from archived tumor board lists from 2010 to 2013. All patients presented to a tertiary care center with squamous cell carcinoma metastases to cervical LN of unknown source despite initial clinical evaluation and computed tomography scan. Fine needle biopsy or excisional biopsy specimens were tested for the p16 biomarker. The accuracy of the PET scan was assessed by comparing the fludeoxyglucose-avid predicted site against a standard panendoscopy with directed biopsies.
A primary was identified in 61% of cases presenting as CUP. All p16+ LN metastases were from an oropharyngeal primary or remained unknown. All primaries located outside the upper aerodigestive tract were p16–. The sensitivity and specificity of PET in patients with p16+ LN metastases were worse than in p16- metastases (71%, 33% vs 100%, 100%).
LN p16 status can help localize CUP. In our series, the sensitivity and specificity of PET scan were much worse in p16+ LN metastases. PET scan may be of limited utility for localizing CUP with p16+ LN metastasis.
Evaluate whether the presence of preoperative thyroglobulin antibody (TgAb) levels can help predict the final pathology of thyroid nodules. Assess whether higher levels of preoperative TgAb increase the likelihood that a thyroid nodule is malignant.
A retrospective chart review of patients who underwent thyroidectomy in 3 McGill University-affiliated hospitals between January 2012 and 2014 was conducted. Demographic data, TgAb levels, and final histopathology were recorded. Patients were divided into 2 groups: TgAb positive (defined as TgAb ≥30 IU/mL) and TgAb low/negative (defined as TgAb <30). Micropapillary thyroid carcinomas were considered to be benign. These data were then statistically analyzed using SPSS.
Preoperative TgAb levels were available in 412 patients. There were 360 patients in the TgAb low/negative group (malignancy rate: 51.39%) and 52 patients in the TgAb positive group (malignancy rate: 65.38%). The sensitivity, specificity, positive predictive value, and negative predictive value of TgAb ≥30 IU/mL as a diagnostic test for thyroid malignancy were 15.53% (confidence interval [CI] 11.00-21.01), 90.67% (CI 85.66-94.38), 65.38% (50.91-78.03), and 48.61% (CI 43.34-53.91), respectively. The relative risk was 1.2723 (CI 1.0192-1.5883) and the odds ratio was 1.7868 (CI 0.9732-3.2804). Both the Pearson chi-square test (
Our study demonstrates that patients with preoperative TgAb ≥30 IU/mL had a higher rate of malignancy when compared to patients with TgAb <30 IU/mL. This suggests that an elevated TgAb level may increase the risk that a thyroid nodule is malignant.
Assess whether a dedicated “one stop” neck lump clinic has helped to improve the percentage of adequate fine-needle aspiration cytology (FNAC) samples and reduce the need for repeat FNAC.
Retrospective review of patients attending for ultrasound-guided FNAC over a 6-month period from August 2012 to February 2013. Patients were placed within 2 groups (Group 1: FNAC performed by any of the subspecialist radiologists with cytology support (n = 100) and Group 2: FNAC performed by general radiologists without cytology support (n = 112)). In order to test for intra-observer agreement, 2 further groups were added (Group 3: FNAC performed by particular subspecialist radiologist with cytology support (n = 61) and Group 4: FNAC performed by the same subspecialist radiologist without cytology support (n = 125).
Seventy-four percent of neck lumps originated from the thyroid, 13% from the salivary glands, and 4% from lymph nodes. Adequacy rates of FNAC in Group 1 were 87% as compared with 56% in Group 2. Adequacy rates of FNAC in Group 3 were 90% as compared with 78% in Group 4. Thus, the presence of immediate cytology and a subspecialist radiologist increased FNAC adequacy by 31%. The presence of cytology support increased adequacy by 12% and presence of a subspecialist radiologist increased adequacy by 22%.
Immediate cytology and the presence of a subspecialist radiologist increase the adequacy of FNAC. The adequacy rate of noncytology supported FNAC or nonsubspecialist FNAC is below the adequate rate expected from the literature or as recommended in national guidelines.
Determine the sensitivity and specificity of fine-needle aspiration (FNA) in the diagnosis of parotid malignancy and analyze those histologies most often associated with false negative and false positive results.
A retrospective chart review was performed for all patients who had a parotidectomy at the University of Wisconsin from 1994 to 2013. Patients who underwent preoperative FNA were identified, and FNA results were categorized as benign, malignant, or indeterminate. Surgical pathology was utilized as the gold standard.
A total of 771 patients underwent parotidectomy from 1994 to 2013, and 280 patients (36.3%) had a preoperative FNA. Based on surgical pathology, 178 (63.6%) patients had benign disease and 102 (36.4%) had malignant parotid neoplasms. 174 (62.1%) FNAs were benign, 94 (33.6%) were malignant, and 12 (4.3%) were indeterminate. Excluding indeterminate cases, the sensitivity and specificity for FNA in the diagnosis of parotid malignancy were 83.7% (95% confidence interval [CI]: (74.8%, 90.4%)) and 93.0% (95% CI: (88.0%, 96.3%)), respectively. Moreover, FNA correctly categorized malignancy in 83.7% (n = 82) and benign in 92.9% (n = 158) of cases. There were 16 false negatives (16.3%) with mucoepidermoid carcinoma having a diagnostic accuracy of 60% and acinic cell carcinoma 50%. Both were most commonly mistaken for pleomorphic adenoma. There were 12 false positives (7.1%), most commonly pleomorphic adenoma (n = 4) and warthins (n = 3).
This study demonstrates that FNA has high sensitivity (83.7%) and specificity (93.0%) for the diagnosis of parotid malignancy. However, mucoepidermoid carcinoma and acinic cell carcinoma are more commonly associated with a false negative FNA.
(1) Examine and meta-analyze the literature on galectin-3 staining on fine-needle aspiration (FNA) samples of thyroid nodules. (2) Summarize the diagnostic test accuracy of galectin-3 staining on FNA for well-differentiated thyroid cancer (WDTC).
A systematic review of studies from 1990 to 2014 examining the diagnostic test properties of galectin-3 on thyroid nodule samples obtained by FNA with regard to WDTC. Data were meta-analyzed using DerSimonian-Laird random effect models for data pooling. Studies were weighted by inverse variance, and between-study variance was estimated using the Empirical Bayes method. Study heterogeneity and threshold effects were analyzed using the Cochrane Q and Spearman correlation coefficient, respectively.
Sixteen studies with 2076 cases were identified. The pooled sensitivity of galectin-3 for WDTC was 89.4% [confidence interval (CI): 87.2-91.4], and specificity was 91.9% (CI: 90.2-93.4). The positive likelihood ratio was 10.05 (CI: 8.24-12.26), and negative likelihood ratio was 0.12 (CI: 0.10-0.15). The diagnostic odds ratio of a positive galectin-3 stain on FNA was 71.3 (CI: 52.7-96.5). The area under the curve for the summary receiver operating characteristics curve (SROC) was 95.3% (standard error: 0.5%).
The current study shows galectin-3 staining of preoperative thyroid nodule FNA samples to be a test with strong diagnostic accuracy for WDTC, as seen by its favorable sensitivity, specificity, diagnostic odds ratio, and SROC curve. This supports its role as a useful adjunct in the preoperative workup of thyroid nodules.
Epithelial-myoepithelial carcinoma (EMC) is a rare neoplasm of the salivary glands. In this study we aim to analyze the clinical features of EMC using national registry data.
Retrospective cohort study. The Surveillance, Epidemiology, and End Results (SEER) database was queried. Data were analyzed with respect to various demographic and clinicopathologic factors. Survival was analyzed using the Kaplan-Meier and Cox proportional hazards models.
A total of 246 cases were available for frequency analysis and 189 for survival analysis. Mean age at diagnosis was 63.8 (±15.4) years. EMC affected females more frequently (57.3%). Distant metastases were present in only 4.5% of cases. Overall disease-specific survival (DSS) at 15 years was 80.2%. Patients with low-grade histology had better DSS at 10 years than those with high-grade tumors (96.2% vs 71.0%,
This report represents the largest series of EMC to date. Despite being regarded as a low-grade, indolent tumor, a significant fraction of our cohort underwent RT in addition to surgery, with no apparent added survival benefit.
Assess the effects of early oral feeding in laryngectomy patients (before 7 days) versus delayed or late oral feeding (7 days or later).
We considered randomized controlled trials (RCTs) irrespective of the use of blinding, language status, date of publication, setting, or sample sizes. The outcomes used were mortality, pharyngo-cutaneous fistula rate, quality of life, hospital length of stay, and complications. To improve harmful effect estimates, trials with early oral feeding groups and a control group were also considered. We analyzed the data with fixed effect and random effect models and present the rate ratios, risk ratio, or mean difference.
We included 4 RCTs and 3 case controlled trials with 393 participants for assessment of harmful effects. The risk of bias in all trials was high. There was no statistically significant difference detected in mortality rates at 6 months, pharyngo-cutaneous fistula rate, or complications between intervention and control groups. There was no data on quality of life. The length of hospital stay was shorter in the intervention early feeding group, mean difference effect estimate and confidence intervals using fixed effect model –2.72 [–5.34, –0.09] in favor of early oral feeding.
The low quality of evidence does not support a change in practice. However, in an appropriate selected patient group early oral feeding has been used and there has been no detectable difference in mortality or complication rates. A shorter hospital stay was seen but was supported by limited evidence.
(1) Examine the association between histopathologic variables and neck metastasis. (2) Analyze the effect of human papillomavirus (HPV) status on lymph node (LN) metastasis.
Medical records of 93 patients who underwent transoral robotic surgery (TORS) with concurrent neck dissection for oropharyngeal squamous cell carcinoma (SCC) between 2008 and 2013 were reviewed.
At the time of presentation, 60 (64.5%) patients had tonsil cancer, 14 (15%) had base of tongue, and 19 (21%) had carcinoma of unknown primary. High risk types of HPV and p16 positivity were 74.4% and 85.4%, respectively. Mean primary tumor size was 2.3 cm (range, 0.3-5.1 cm). Nodal status based on pathologic examination were N0 in 7 (7.5%) patients, N1 in 12 (12.9%), N2a in 25 (26.9%), N2b in 37 (39.8), N2c in 5 (5.4%), and N3 in 7 (7.5%). Average positive LN number was 2.56 (range, 0-37). Extracapsular spread (ECS) was identified in 29.1% of all patients. Primary tumor size had no effect on positive LN size, number or ECS. HPV positivity (rs = 0.25,
HPV positivity, p16 overexpression, and lymphovascular invasion increase the risk of cervical lymph node metastasis. Increased primary tumor size does not necessarily mean advanced neck disease.
Determine the effectiveness of intraoperative facial nerve monitoring (FNM) in preventing immediate and permanent postoperative facial nerve weakness in patients undergoing primary parotidectomy.
Systematic review and meta-analysis. A comprehensive literature search was conducted using the PubMed-NCBI database from 1970 to 2014. Acceptable studies included controlled series that evaluated facial nerve function following primary parotidectomy with or without FNM (intraoperative nerve monitor vs. control). Primary and secondary endpoints were defined as immediate postoperative and permanent facial nerve weakness (≥2 House-Brackmann score), respectively.
A total of 1414 articles were reviewed, resulting in 8 articles that met inclusion criteria. In total, 626 patients were included in the final meta-analysis. The incidence of immediate postoperative weakness following parotidectomy was significantly lower in the FNM group compared with the unmonitored group (22.4% vs 35.0%,
In primary cases of parotidectomy, intraoperative facial nerve monitoring decreases the risk of immediate postoperative facial nerve weakness, but does not appear to influence the final outcome of permanent facial nerve weakness.
(1) Demonstrate that head and neck squamous cell carcinoma (HNSCC) can be fluorescently imaged using a matrix metalloproteinase (MMP)-cleavable, ratiometric activatable cell-penetrating peptide (RACPP). (2) Correlate extent of tumor involvement with fluorescent signal.
Increased expression of MMP-2 and MMP-9 has been well documented in multiple cancers. We developed an injectable probe (RACPP) that exhibits ratiometric fluorescence (increased Cy5:Cy7 ratio) when cleaved by these proteinases. To examine the utility of MMP2,9-cleavable RACPPs in HNSCC, mice were injected with 5 human HNSCC cell lines to establish orthotopic tongue xenografts (n = 22). Tumor-bearing mice were imaged in-vivo after intravenous RACPP injection. Fluorescent signal was correlated with histology by a blinded pathologist. Gelatinase zymography confirmed MMP-2,9 activity in these xenografts. For ex-vivo analysis of human HNSCC specimens, RACPP was applied to homogenized samples (n = 5), and fluorescence was measured on a microplate reader.
Orthotopic tongue HNSCC xenografts showed excellent ratiometric fluorescent labeling with MMP2,9-cleavable RACPP (sensitivity = 95.4%, specificity = 95.0%). Signal intensity, as defined by ratiometric contrast, was greater in areas of higher tumor burden (
Fluorescent labeling with MMP2,9-cleavable RACPP is an effective way to visualize HNSCC in-vivo in a murine model, and signal intensity correlates with tumor burden. RACPPs have the potential to improve occult tumor identification and margin clearance in HNSCC. Ex-vivo assays using biopsy specimens may help identify patients who will benefit from intraoperative RACPP use and may be useful in retrospective analyses.
Surgery is the definitive treatment for oral tongue squamous cell carcinoma (OSCC). Studies have described correlates of delayed diagnosis. However, little is known about treatment delays after diagnosis. This study investigates time intervals from diagnosis to surgery for OSCC using the National Cancer Data Base (NCDB).
The NCDB was queried for OSCC patients initially treated with surgery in 1998 through 2009. Patients were dichotomized based on time to surgery relative to the median. Chi-square and multivariable logistic regression models were used for statistical analyses.
A total of 14,270 patients were identified. The median age was 60 years (range, 18-90 years). For all stages, the median time from diagnosis to surgery was 27 days (SD = 42). Factors that predicted a longer interval to surgery included: advanced stage (28 days), Hispanic ethnicity (29 days), lack of health insurance (29 days), treatment at an academic/research facility (29 days), residence >75 miles from the hospital (31 days), treatment in the Middle (29 days) and South Atlantic (28 days) states, and having a referral to a different treating center (30 days). The strongest predictors of time delay were having a referral (odds ratio [OR] 1.97, 95% confidence interval [CI] 1.83-2.13,
There is significant variation in the time from diagnosis to surgery for patients with OSCC. Several patient, geographic, and facility factors predict treatment delays. These findings can be used as a benchmark for quality of care and to guide further investigation into whether timing disparities affect outcomes.
(1) Apply the concept of failure to rescue to outcomes research in head and neck cancer (HNCA) surgery. (2) Understand the relationship between hospital volume and failure to rescue.
Discharge data from the Nationwide Inpatient Sample for 159,301 patients who underwent an ablative procedure for a malignant oral cavity, laryngeal, hypopharyngeal, or oropharyngeal neoplasm in 2001 to 2010 were analyzed using cross-tabulations and multivariate regression modeling. Failure to rescue was defined as death after a major complication including acute myocardial infarction, acute renal failure, venous thromboembolism, pneumonia, gastrointestinal bleed, pulmonary failure, hemorrhage, or surgical site infection. We compared the incidence of mortality, complications, and failure to rescue across hospital volume tertiles.
The majority of hospitals performing HNCA surgery were low-volume hospitals (N = 7635), which performed an average of 6 cases per year. Intermediate-volume hospitals (N = 729) performed a mean of 37 cases per year, and high-volume hospitals (N = 207) performed a mean of 131 cases per year. High-volume hospitals were associated with significantly decreased odds of death (0.7% vs 1.0%, odds ratio [OR] 0.56 [0.46-0.86]) compared with low-volume hospitals. There was no significant difference in major complication rates at high-volume hospitals compared with low-volume hospitals (18.5% vs 15.6%, OR 0.96 [0.80-1.15]); however, high-volume hospitals were associated with significantly decreased failure to rescue rates (3.1% vs 4.4%, OR 0.56 [0.33-0.97]) compared with low-volume hospitals.
Improved survival among patients undergoing HNCA surgery at high-volume hospitals appears to be associated with differences in the response to and management of complications, rather than differences in complication rates.
Dissect the impact of human papillomavirus (HPV) on angiogenesis in head and neck cancers (HNSCC).
We analyzed 18 newly diagnosed HNSCC patients and controls. HPV tumor status was ascertained by p16 staining. Eleven pro- and anti-angiogenic factors were quantified in sera using a multiplex assay. Angiogenic factors were analyzed in the tumor tissue using immunohistochemistry.
We found that circulating levels of anti-angiogenic factor endostatin were higher in all HNSCC patients compared with healthy subjects irrespective of HPV status. Notably, we detected higher levels of the proangiogenic factors angiopoetin-1 and vascular endothelial growth factor (VEGF) in the circulation of HPV-negative patients compared with patients with HPV-positive tumors. Interestingly, levels of thrombospondin-2, an antiangiogenic factor, were lower in the circulation of patients with HPV-positive compared with HPV-negative tumors and healthy controls. We next analyzed these angiogenic factors in the tumor tissue. Interestingly, while HPV-negative tumors exhibited VEGF expression both in tumor tissue and stromal cells, only a fraction of HPV-positive tumors exhibited VEGF expression in tumor tissue. Angiopoietin-1 was expressed in tumor cells as well as endothelial cells in the stroma. Another interesting finding was that macrophages in HNSCC had an M2 “alternatively activated” phenotype and appeared to be the major source of endostatin in the stroma.
Our novel results indicate that angiogenic factors are differentially expressed in the circulation and tumor tissue in HPV-positive and HPV-negative HNSCC and could potentially confer a more aggressive phenotype to HPV-negative tumors.
Assess the rate of hypothyroidism following hemithyroidectomy.
A retrospective study in adult patients undergoing hemithyroidectomy at the McGill University Thyroid Cancer Centre, during the years 2007 through 2012. Patients with preoperative hypothyroidism were excluded. Patients were followed 12 to 60 months after the primary surgery, and preoperative thyroid stimulating hormone (TSH) and free T4 levels were compared before and after the surgery. Hypothyroidism was defined as TSH levels >4.5 mU/L.
Of the 181 eligible patients in this study, 137 (75%) were females, with a mean age of 49.1 ± 14.3 years.The most common indication for surgery was follicular lesion. Hypothyroidism occurred in 65 (35%) of the patients, and was diagnosed at 1 to 36 months after surgery. Age and sex were not found to be risk factors for post-hemithyroidectomy hypothyroidism.
In this study 35% of patients undergoing hemithyroidectomy develop postoperative hypothyroidism. Upon preoperative patient counseling, hypothyroidism is a major morbidity that should be thoroughly discussed.
Study hypocalcemia incidence and trends over time following completion thyroidectomy (CT) versus total thyroidectomy (TT).
A retrospective study comparing hypocalcemia and hypoparathyroidism incidence rates in all patients who underwent CT and in a random control group of TT at the McGill University Thyroid Cancer Centre, during the period of 2007 through 2012. Data were collected for demographic, clinical, and pathological characteristics.
There were 68 CT patients and 146 TT patients. Transient hypocalcemia occurred in 1 out of 68 (2%) and 18 out of 146 (12%) inpatients in the CT and TT groups, respectively. The rate of hypocalcemia was significantly lower in the CT group when compared with the TT group (
In this study, the risk of transient hypocalcemia in patients undergoing CT was significantly lower than the rate of hypocalcemia in patients undergoing TT.
(1) Describe the effectiveness of indocyanine green (ICG) as an imaging agent for head and neck tumors. (2) Illustrate the potential of near-infrared imaging for intraoperative visualization of cancers.
Patients underwent intravenous administration of 7.5mg ICG during the surgical procedure. The SPY/LUNA (Novadaq) near-infrared intraoperative imaging system was used prior to resection and the Pearl (LICOR) and Odyssey (LICOR) systems for ex-vivo tumor imaging. Tumor-to-background ratio (TBR) was defined as tumor fluorescence divided by normal tissue fluorescence. Histologic analysis was performed with a head and neck cancer board-certified pathologist.
Five patients were enrolled into this study between August and September 2013. Three patients had pharyngeal cancer, one had laryngeal cancer, and one had cutaneous cancer. TBR values of confirmed cancer tissue varied among patients (LUNA TBR 3-9, Pearl TBR 3-18). However, in 2 patients, areas of highest fluorescence were found to be absent of carcinoma on histological analysis. The epidermal portions of the cutaneous SCC lesion were highly fluorescent, but the tumor did not penetrate this layer in multiple sections. Histologic analysis of these tissues confirmed significant areas of acute and chronic inflammation at areas of high fluorescence intensity. Skin, mucosal surfaces, and perivascular areas were most prone to false-positive high fluorescence.
While intravenous ICG does accumulate in head and neck tumors sufficiently to distinguish them from normal tissue, it is not specific enough to serve as a tumor visualization agent. Targeted fluorescent probes will likely be needed for image-guided surgery.
To present the first cases of laryngeal rehabilitation by an artificial larynx performed after a total laryngectomy. The prosthesis aims at proposing an alternative to laryngeal transplantations and to techniques of tissular engineering and/or transplants by free fragments, used essentially in tracheal reconstructions.
The artificial larynx was developed thanks to fundamental biomaterial research and long-term animal experiments. The insertion is a 2-stage procedure. The first step, performed immediately after the total laryngectomy, consists of connecting the trachea with a hollow titanium tube. After a 6-week period of healing, or 3 months after radiotherapy, a swallowing valve is fixed over the integrated titanium tube (second step).
Four patients have been treated (2 whole prosthesis, 2 partial prostheses) from June to December 2012. Two patients were able to talk in a whispering fashion while the tracheostomy was temporarily closed; their functioning in the relevant postoperative problem areas, such as swallowing, breathing, and smelling were significantly improved.
Our clinical trials demonstrated that a temporary closure of the tracheostomy opening can be achieved. Potential improvements of this larynx replacement open real perspectives of complete rehabilitation after total laryngectomy. The artificial larynx, which does not require immune-suppressor treatment, would avoid the definitive tracheostomy, considered by most patients as a loss of physical and psychological integrity.
Otolaryngology trainees undergo regular procedure-based assessments (PBAs) throughout training; however, these are rarely used to analyze performance and monitor progress. The aim of the study was to validate PBA in assessing otolaryngology trainees in head and neck surgery (HNS) and identify the pattern by which trainees progress in syllabus HNS procedures.
We analyzed all PBAs from North-Thames otolaryngology trainees, during early years or core (CT) and more senior specialty training (ST) years from 2008 to 2013. We used mean scores and standard deviations to draw procedure-specific learning curves. The PBA tool is procedure-specific. It is produced by the Joint Committee of Surgical Training and is used in assessing UK surgical trainees performance in all specialties. The tool is composed of 6 main domains: consent, planning, preparation, exposure/closure, technique, and postoperative care.
A total of 3306 PBAs from 46 trainees were identified; 1806 were HNS. PBA reliability was shown by high internal consistency (Cronbach’s Alpha:0.921) and discriminated between grades (CT and ST, Mann-Whitney
Procedure-specific learning curves can be drawn to set milestones and deliver targeted training. Curves of various HNS procedures plateau at different stages in training. This method is more robust and should replace arbitrary numbers as a measure of competence.
Systemic chemotherapy is the basic palliative treatment for metastatic nasopharyngeal carcinoma (mNPC) at diagnosis; however, the impact of locoregional radiotherapy (lrRT) targeting the primary and regional lymph nodes on the survival of mNPC patients remains unknown and will be evaluated here retrospectively.
A total of 408 mNPC patients were included in this study. The mortality risks were compared between the untreated patients and the patients who underwent chemotherapy and lrRT delivered alone or in combination. Univariate and multivariate analyses were conducted. The contributions of independent factors were adjusted by other covariates with significant prognostic association (
Both lrRT and systemic chemotherapy were found to be significant independent prognostic factors of overall survival (OS). The group receiving lrRT alone exhibited similar mortality risk compared to the group who underwent systemic chemotherapy alone (multiadjusted hazard ratio [HR], 0.9;
Locoregional radiotherapy, particularly combined with systemic chemotherapy, was correlated with the improved survival of mNPC patients.
(1) Recognize how ERCC1 biomarker development in HNSCC has been impaired by use of 8F1, a nonspecific ERCC1 antibody, which also recognizes PCYT1A, a protein unrelated to DNA repair capacity. (2) Verify that specific ERRC1 antibodies, 4F9 and FL297, were more useful than 8F1 for prognosis of HNSCC patients undergoing cisplatin-radiation on a phase II trial. (3) Demonstrate the relative contribution of PCYT1A and ERCC1 in variation of 8F1 expression.
We hypothesized that co-detection of PCYT1A could explain variation in 8F1 expression, and account for lost prognostic performance as compared with 4F9 and FL297. Pre-treatment tissue from 75 trial patients with previously characterized 4F9, FL297, and 8F1 expression was stained for PCYT1A. Quantitative digital IHC was performed, blinded to clinical outcomes. Expression was compared among the 4 antibodies.
High expression of 4F9 (hazard ratio [HR] 3.12;
ERCC1 expression by specific antibodies is a resistance biomarker for platinum-based therapy in HNSCC. Although 8F1 detects ERCC1, cross-reactivity with PCYT1A confounds 8F1 scoring. Because of nonspecificity, 8F1 should be abandoned.
Metabolic tumor volume (MTV) obtained from pretreatment 18F-fluorodeoxydeglucose positron emission tomography with computed tomography (PET-CT) has been validated as an independent predictive factor of outcomes in head and neck cancer patients (HNC) treated with primary chemoradiotherapy (CRT). However, its role in patients treated with primary surgery has not yet been studied. The aim of the study was to evaluate the prognostic value of MTV in patients treated with primary surgery for oral cavity squamous cell carcinoma (OCSCC).
Demographic and survival data were obtained from patients diagnosed with OCSCC from 2008 to 2012 in Alberta, Canada. All patients included in the study had positron emission tomography–computed tomography (PET-CT) scan before curative surgical resection. MTV and maximum standardized uptake value (SUVmax) was delineated from pretreatment PET-CT scans using Segami Oasis software (Columbus, OH).
A total of 80 patients were analyzed using SPSS (SPSS Inc, Chicago, IL). Five-year overall, disease-specific, and disease-free survival using Kaplan-Meier curves were 72%, 79%, and 78% respectively. An increase in MTV of 17.5 mL (difference between the 75th and 25th percentile) was associated with a 1.9-fold increase in risk of disease recurrence (
This study shows that MTV is an adverse prognostic factor for death and disease recurrence in OCSCC treated with primary surgery.
Determine the incidence and factors influencing neck disease, at presentation and delayed, in patients with olfactory neuroblastoma.
Patients with a histological diagnosis of olfactory neuroblastoma that were treated across 6 tertiary hospitals were included. Treatment modalities to primary site and neck included radiotherapy, surgery, and combinations. The status of cervical lymph node metastases at presentation and at last follow-up was defined. Disease-free survival (DFS) was calculated as time taken for patients to develop delayed neck disease following primary treatment of olfactory neuroblastoma. Pearson correlation, regression analysis, and Kaplan Meier plots were performed to identify risk factors for developing cervical neck metastases.
A total of 113 patients (46 females, 49.7 ± 13.2 years) with median follow-up of 41.5 months (interquartile range, 58.2 months) were identified. Of the patients, 7.1% presented with primary neck disease while 8.8% of patients presented with delayed neck disease. Neck disease, both primary and delayed, was present in patients with Hyams grade II (22.2%), III (55.6%), and IV (22.2%) lesions (χ2 2 5.66,
Neck metastasis is an important clinical consideration for olfactory neuroblastoma both at presentation and in surveillance. Primary treatment of the neck could be considered in select patients.
(1) Determine the impact of adjuvant radiotherapy on high-risk head and neck basal cell carcinoma (H&N BCC). (2) Analyze risk factors associated with recurrence and survival.
Case series with planned chart review (2002-2013) in an academic tertiary care center. A total of 431 consecutive patients presented with H&N defects requiring free flap reconstruction, 38 specifically for aggressive BCC. Cases were classified as high risk based on National Comprehensive Cancer Network (NCCN) criteria. Overall and disease-free survival were examined using Kaplan-Meier analysis. Independent variables included: site, recurrent tumor, radiation, bony involvement, and perineural invasion. Complications were reported.
Nineteen (50%) lesions were recurrent. Mean tumor diameter was 5.17 cm (1.2-15.0cm). Mean follow-up was 19.9 months. Overall 2-year survival was 80%, falling to 66% at 5 years. Two-year disease-free survival was 72%. Six patients recurred (5 local; 1 distant). Adjuvant radiotherapy was utilized in 17 (44.7%) and did not significantly impact recurrence (
Larger H&N BCC do not confer worse outcomes, independent of subsite. Adjuvant radiotherapy does not improve survival or recurrence. Bony involvement does not correlate with survival and should not preclude surgical intervention, even in advanced cases.
Oral cancer has high incidence and prevalence rates. Despite the fact that the oral cavity might be easily observed, the diagnosis of oral cancer is usually done later than expected. Early diagnosis is the main oral cancer challenge to decrease morbidity and mortality. Contact endoscopy allows the assessment in vivo and in situ of epithelial cells, glandular ostia, and microvascular network (60X, 150X). The authors describe the contribution of contact endoscopy in performing real time histological diagnosis and guide biopsies in an office setting.
The authors carried out a prospective double blind study (July 2012 - February 2014) where diagnosis was made by contact endoscopy and histology (gold-standard) in a population of 122 patients with oral lesions persisting without involution for 3 weeks, considering a clinical classification: benign (n = 26), premalignant (n = 83), and malignant (n = 13). Sensitivity, specificity, negative and positive predictive values, and likelihood ratios were calculated.
Sensitivity and specificity were superior to 95%. By the identification of the cellular and vascular heterogeneous patterns characteristic of a malignant lesion, contact endoscopy allowed the definition of real cellular margins and the detection of suspicious areas without macroscopic disease.
In our study, contact endoscopy allowed in an office setting a precise diagnosis with similar effectiveness of histology. This noninvasive technique was revealed to be an important guide for biopsies, an easy way to define real safety surgical margins, and a good way to improve follow-up efficiency. The authors concluded that contact endoscopy has good potential to improve oral cancer’s early diagnosis.
Most patients treated with organ-preservation schemas for laryngeal cancer have no nodal disease at the time of recurrence. The oncologic benefit of an elective neck dissection (END) in a patient with clinically N0 neck at the time of salvage laryngectomy (SL) is still controversial. We sought to determine the oncologic outcomes for END and identify predictors for pN(+) status.
Retrospective chart review of 180 patients who underwent laryngectomy between 2004 and 2013 was performed. Fifty-eight patients met inclusion criteria and the cohort was divided into 2 groups depending upon the END status. Demographics, pathology, and oncologic outcomes were compared.
The study was comprised of 46 (79.3%) males and 12 (20.7%) females with a mean age of 60.5 years (range, 24-88 years; SD = 10 years). Nineteen patients (32.8%) were managed conservatively while 39 (67.2%) had END, uni- or bilateral. Out of a total of 71 ENDs, 5 necks in 4 patients had positive nodal disease. The only statistically significant predictor for pN(+) status was T-stage (
We found that 7% of the dissected necks had positive disease, and the only predictor for pN(+) status was tumor T-stage. END did not improve locoregional control or survival compared to observation. Our findings suggest END is warranted in patients presenting with locally advanced recurrences, while observation might be preferable in other instances.
(1) Understand the principles for safe outpatient thyroid surgery. (2) Review the outcomes of outpatient thyroid surgery in a large patient cohort.
A protocol for outpatient thyroidectomy was conceived and refined over 3 years. A prospective analysis of all thyroidectomies accomplished by a single surgeon using this protocol from May 2008 to November 2013 was then undertaken. Patient demographics, surgical and pathological data, admission status, and complication and readmission rates were recorded.
A total of 1311 thyroidectomy procedures were performed during the study period, of which 1018 (77.7 %) were conducted on an outpatient basis. The readmission rate for outpatients was 0.8%, with only 1 readmission in the last 200 procedures. Inpatients were readmitted more often than outpatients (3.9% vs 0.8%,
Outpatient thyroid surgery is safe in appropriately selected patients using an optimized and systematic protocol.
Microvascular free tissue reconstruction is overall successful in the treatment of patients with disfiguring wounds resulting from ablative cancer resection, trauma, and osteo(radio)necrosis. Flap failure can be devastating for patients and health care providers. The use of sympathomimetic drugs (vasopressors) in microvascular surgery is controversial; however, current research fails to demonstrate adverse outcomes when intraoperative vasopressors are used. Conversely, intraoperative fluid administration greater than 7 L has been associated with major postoperative complications. The aims of the study were: (1) determine the efficacy of postoperative vasopressor use in free flap patients; (2) compare length of hospital stay in patients who receive vasopressors postoperatively and those who do not.
In this retrospective pilot study, we investigated the use of a postoperative hypotension treatment protocol at our institution, implemented in June 2013. Thirty-nine patients underwent free flap reconstruction of the head and neck secondary to malignancy. Outcome measures included flap viability and length of hospital stay.
Analysis of this ongoing study reveals that 23% of patients received peripherally-active vasopressors within the first 3 postoperative days. There were no flap failures in either group. We found no statistically significant difference in the rate of surgical reexploration in patients who received vasopressors postoperatively compared to patients who did not (Fisher’s exact test,
The length of hospital stay is not statistically significantly different when vasopressors are used postoperatively. The implementation of a formalized hypotension treatment protocol in the postoperative setting does not adversely affect the outcome of free flap survival or length of hospital stay.
(1) Recognize that a number of patients with primary hyperparathyroidism will continue to manifest elevated parathyroid hormone (ePTH) despite achieving eucalcemia after curative parathyroidectomy. (2) Identify the preoperative factors that may contribute to this phenomenon. (3) Counsel patients and physicians regarding these factors to prevent unnecessary reoperative surgical procedures in response to postoperative elevated parathyroid hormone.
Records of all patients who underwent curative primary surgery for single gland parathyroid adenomas at Georgia Regents Department of Otolaryngology Head and Neck Surgery between January 2009 and April 2013 were retrospectively reviewed. Patient demographic data and preoperative PTH, calcium, ionized calcium, 25-OH-vitamin D, creatinine, and glomerular filtration rate (GFR) levels were recorded, along with postoperative calcium, ionized calcium, and PTH levels. The values from patients with ePTH and normal PTH postoperatively were compared.
Of 119 patients meeting inclusion criteria, 30 (25.2%) demonstrated postoperative ePTH with eucalcemia. This group had significantly higher preoperative PTH (
The postoperative PTH levels remain elevated in 25.2% of patients achieving eucalcemia after surgery for primary hyperparathyroidism. This phenomenon was associated with compromised preoperative renal function. Physicians and patients must be aware of this condition to avoid subjecting patients to unnecessary further intervention.
Perineural invasion (PNI) has emerged as an adverse pathological feature of adenoid cystic carcinoma (ACC). Despite their importance, the local control factors involved in PNI remain unknown. Recent research has suggested that nerve growth factor (NGF) may be one of the important factors for PNI in other malignancies. Furthermore, in ACC, Myb overexpression related to the MYB–NFIB fusion gene has been correlated with PNI; however, this concept has been highly controversial. In this study, we examined the overexpression of NGF, its receptors (TrkA and p75NRT), and Myb in ACC cancer cells and investigated the relationship with PNI and local control.
We retrospectively analyzed 47 patients with ACC who were surgically treated from 1991 to 2011. We reviewed NGF, TrkA, p75NRT, and Myb overexpression in the surgical specimens and examined the correlation with PNI, local control, and disease-specific survival.
The overexpression rates of NGF, TrkA, p75NRT, and Myb were 66%, 66%, 30%, and 57%, respectively. NGF and TrkA were significantly overexpressed in the PNI-positive group (NGF overexpression rate: PNI-positive vs PNI-negative, 88% vs 20%,
NGF and TrkA overexpression may contribute to PNI and cause local recurrence in ACC. However, Myb overexpression was not related to PNI in our analysis.
Investigate whether intraoperative parathyroid hormone (PTH) can predict postoperative hypocalcemia following total thyroidectomy.
Cohort study with chart review of total or completion thyroidectomy patients in academic and private settings from May 2013 to February 2014. A total of 42 patients who underwent total thyroidectomy with or without central node dissection were enrolled prospectively. PTH were measured at 2 time points: preincision after induction of general anesthesia and postexcision 20 to 30 minutes following total thyroidectomy. Serum calcium was measured at midnight after surgery (6 hours) and the next morning at 6
Preincision PTH did not show any correlation with 6-hour calcium. Postexcision PTH values stratified in an interval of 50 were not associated with significantly different calcium levels (PTH 50-99.9, Ca 8.2; 100-149.9, 8.4; 150-199.9, 8.2). Patients with PTH less than 50 had a decreased mean calcium at 7.7; however the reduction was not statistically significant (
Preincision PTH is not a reliable predictor of postoperative hypocalcemia. A decrease of 75% or more in PTH following total thyroidectomy is more likely to result in postoperative hypocalcemia.
Studies evaluating complications after neck dissection alone or in conjunction with other procedures are sparse. We looked for predictors of adverse events after neck dissection using the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP), which tracks 30-day complication rates in patients undergoing surgery at participating centers.
In this retrospective review, 619 patients were identified using CPT codes specific for neck dissection. Clinical factors, comorbidities, epidemiologic factors, and procedure characteristics were analyzed with multiple regression to evaluate relationship to complication rates.
Twenty-three percent of patients (142 of 619 patients) underwent neck dissection and experienced either a medical or surgical complication. Factors associated with adverse events included previous cardiac surgery (odds ratio [OR] 3.376, 95% confidence interval [CI] 1.084-10.516,
This study presents important benchmarks for medical and surgical complication rates, reoperation, and mortality observed with neck dissection in a large nationally abstracted patient sample. Cardiorespiratory morbidity and surgical complexity were found to be major drivers of complications. The true complication rates may be underrepresented due to inadequate tracking of procedure specific complications in NSQIP.
(1) Discuss primary surgical excision of head and neck venous malformations (VMs) and possible need for subsequent therapy. (2) Describe outcomes of primary surgical excision of VMs of the head and neck.
We conducted a retrospective chart review of 45 patients (23 females and 22 males) treated with primary surgical excision of head and neck VMs who presented between 2001 and 2012 to a tertiary pediatric academic institution with a multi-disciplinary vascular anomalies center.
Mean age at presentation was 10.2 years, with a higher average age for female patients (11.7 years) than male patients (8.6 years). The most common anatomical subsites were the face/cheek (22.2%), neck (17.8%), and lower lip (11.1%). A majority of patients (73.3%) experienced significant improvement after the initial excision, though 42.2% of patients ultimately required subsequent treatments (either repeat excision, laser therapy, or sclerotherapy) to obtain overall disease control. The majority of patients (57.8%) required only the initial surgical excision for adequate treatment. Few patients experienced postoperative complications. The most common patient complaint was transient postoperative edema. The main outcome measures included need for subsequent treatments after excision, overall improvement (significantly decreased size or resolution of VM and decreased pain) postoperatively, and postoperative complication rate/patient complaints.
Venous malformations of the head and neck are uncommon. However, when appropriately selected for surgical excision, most do not require subsequent treatment for disease control. We present a series of 45 patients who were treated with primary surgical excision, 57.8% of whom required no further treatment.
Analyze the relationship between obesity and type-2 diabetes (DM-II) and the development of differentiated thyroid cancer (DTC).
Randomized case-controlled retrospective chart review conducted for outpatient clinic patients between January 2005 and December 2012 at an academic medical center. Forty-nine DTC patients were compared with 70 control group patients diagnosed with hyperparathyroidism with documented euthyroid state. Exposure variables consisted of the most recent body-mass index (BMI) within 6 months prior to diagnosis of DTC and any report of DM-II. Multivariate logistic regressions adjusting for sex, age, and year of body mass index (BMI) were used to assess the odds ratio of DTC with both BMI and DM-II. No interventions were performed.
Comparison of means shows BMI was greater in patients with DTC (BMI = 37.83) than controls (30.36),
Our preliminary results show that obesity, and to a slightly lesser degree DM-II, are significantly associated with DTC. BMI in particular was a strong predictive variable for DTC (C = 0.81 bivariate, C = 0.82 multivariate).
Historically, head and neck squamous cell carcinoma (HNSCC) has been considered a lymphatic malignancy with regional disease. Recently, this has been called into question. Our study aims to (1) illustrate the robust differences between p16+ and p16- oropharyngeal squamous cell carcinoma (OPSCC), and (2) provide circumstantial evidence that p16+ OPSCC has a predilection toward active vasculature invasion and hematogenous spread.
A multi-institutional, retrospective study of 1060 patients with OPSCC undergoing definitive treatment between 1979 and 2012. Patients were divided into 2 cohorts: p16+ and p16- OPSCC. Differences in distant metastases (DM) between the 2 cohorts were assessed for risk factors, rate and temporal differences, phenotypic behavior, and post-DM progression-free and disease-specific survival.
Of the 1060 patients, 105 patients had DM. Thirty-four were p16- and 71 were p16+. Full statistical analysis has yet to be completed, but preliminary findings conclude that of the p16- patients with DM, only 6% had disseminated disease (distant metastases at >1 site) as compared with 70% of p16+ patients with DM. Distant disease in p16+ patients included brain and unique bilateral lung findings.
Our large, multi-institutional study supports the previously reported claim that patients with p16+ OPSCC have a unique phenotypic disseminated behavior. This calls into question the belief that HNSCC is a lymphatic malignancy. Our data suggest that p16+ disease has a predilection toward active vasculature invasion evidenced by atypical end-organ DM and dissemination profile. This study’s findings coupled with data in the literature may have implications for future p16+ OPSCC targeted therapy.
Evaluate the role of modifiable patient risk factors including tobacco use, secondhand smoke exposure, alcohol consumption, and body mass index (BMI) in the development of thyroid cancer.
Retrospective study comparing Midwest thyroid cancer patients from our multicenter Thyroid Tumor and Cancer Registry and Midwest controls without personal history of cancer. Descriptive statistics were created from detailed questionnaires, thyroid cancer type, and odds ratios were reported for significant associations.
There were 469 cancer patients and 425 controls. The thyroid cancer group included 406 papillary, 47 follicular, 13 medullary, and 3 anaplastic cancers. Comparing all cancer patients with controls, there was no association between smoking and thyroid cancer (
Our data suggest that secondhand smoke exposure is a risk factor for developing thyroid cancer and mild alcohol consumption is associated with reduced risk of developing thyroid cancer. BMI over 30 may be associated with thyroid cancer development for individuals over 45 years old.
(1) Determine the role of oncogene dependence on one of the more common and targetable oncogenes in head and neck squamous cell carcinoma (HNSCC) PIK3CA. (2) Evaluate the consequence of this oncogene on the effectiveness of newly developed targeted therapies.
A basic science study was performed to test the hypothesis that PI3KCA hot spot mutations confer increased sensitivity or oncogene addiction to PI3K and related inhibitors. The PI3KCA hotspot mutations—E545K and H1047R—were engineered within the HNSCC cell line SCC25. Cell viability was measured using high throughput microscopy to determine the survivability cell lines expressing the hotspot mutations compared with control cell lines when treated with increasing concentrations of newly developed targeted therapies 17-AAG, GDC-0941, and Trametinib.
Surprisingly, hotspot E545K and H1047R mutations conferred increased rather than reduced survivability when treated with increased concentrations of the respective HSP90, PI3K, and MEK inhibitors, 17-AAG, GDC-0941, and Trametinib compared to the SCC25 control cell lines.
(1) The PIK3CA mutations within our engineered cell model did not lead to oncogene dependent cell death when treated with targeted therapy including direct inhibition of the Phosphatidylinositol 3-kinase (PI3K) enzyme. (2) Oncogene addiction to PIK3CA hot spot mutations, if it occurs, is likely to evolve in vivo in the context of additional molecular changes that remain to be identified.
(1) Analyze survival, complications, and impact of transnasal endoscopic cranial base surgery. (2) Describe time course and patterns of local, regional, and distant failure patients with olfactory neuroblastoma (ONB) of the nasal cavity, ethmoid sinus, and/or anterior skull base.
Review of prospectively collected clinical data of patients treated by a single head and neck surgeon at 2 academic medical centers over 16 years.
Thirty-seven patients were diagnosed with ONB confirmed by immunohistochemistry between 1996 to 2010, and 31 are available for review. There were 10 women and 21 men with a mean age of 50.9 years. Patients were treated with primary resection and no additional therapy (4), radiation therapy (24), or chemotherapy enhanced radiation therapy (3). Primary resections included open medial maxillectomy without craniotomy (n = 2), endoscopic anterior craniofacial resection (CFR) (n = 9), and open CFR (n = 20). Mean and median overall survivals were 95.95 and 80.62 months, respectively (range, 6.53 to 242 months). Operative complications were only observed in patients undergoing open CFR. Recurrences were either limited to the neck (3/11), the neck and a distant site (3/11), or distant sites alone (5/11). Time interval to the development of recurrence ranged from 3 to 186 months, and only patients with isolated recurrences could be salvaged. Intradural tumor extension correlated with recurrence but not necessarily early death.
Margin negative resection of ONB should remain the goal of primary treatment. Long-term follow-up is necessary to identify patients with isolated recurrences who would benefit from aggressive salvage therapy.
Surgeries performed for primary parotid malignancies vary, and the oncologic outcomes are undetermined. This study aims to: (1) Describe surgical outcomes of superficial versus total parotidectomy, and (2) describe surgical outcomes of observation versus cervical lymphadenectomy in patients with a N0 neck.
Records of 129 consecutive patients with non-metastatic primary parotid cancer treated from 1988 to 2010 at the University of Utah and Intermountain Healthcare were reviewed. Treatment was superficial (47%) or total (53%) parotidectomy, 31% underwent concurrent cervical lymphadenectomy, and 67% received adjuvant radiotherapy due to high-risk features. Patient demographics, tumor characteristics, surgical treatments, and oncologic outcomes were statistically analyzed.
Average age at diagnosis was 52 years. Mean follow-up was 7.4 years. Patient demographics, tumor grade, and histology were not predictive of recurrence or survival. Matching patients with Stage I/II disease (n = 74) and comparing superficial versus total parotidectomy, there was no difference in 5-year disease free rate, and 5- and 10-year overall survival rates (85%, 95%, and 88% versus 84%, 84% and 67%, respectively). Also, for Stage III (n = 18) and IV (n =33) disease there was no difference. For 101 patients with a N0 neck, 81 were observed and 20 underwent an elective cervical lymphadenectomy; there was no difference in outcomes (76%, 85%, and 72% versus 73%, 87%, and 67%, respectively).
Treatment of primary parotid cancer requires meticulous surgical dissection and gross tumor resection; however, superficial versus total parotidectomy or observation versus elective cervical lymphadenectomy does not affect tumor recurrence rates or overall survival outcomes.
Compare the safety and efficacy of primary tracheoesophageal puncture (TEP) and prosthesis fit with traditional methods, such as secondary TEP or primary TEP with catheter stenting (secondary fit).
Retrospective cohort study of patients who underwent total laryngectomy with TEP between 2009 and 2013. Voice outcome was assessed as voice production at the first postoperative appointment and TEP usage at 6 months and 1 year following puncture. Perioperative emergency department visits, pharyngocutaneous fistula (PCF), and stomal breakdown were analyzed.
Ninety patients were included. Seventy-three had primary TEPs, of which 32 were catheter stented and 41 were fitted primarily. The remainder (17) had secondary TEPs, of which 8 were primarily fit. Patients with primary fittings were less likely to come to the emergency department postoperatively (14% vs 39%,
Primary TEP with primary fit represents a safe and effective approach to vocal rehabilitation following total laryngectomy.
(1) Compare survival of patients with spindle cell carcinoma variant (SpCC) to survival of patients with conventional squamous cell carcinoma (SCC). (2) Describe the impact of patient demographics and tumor characteristics on survival with SpCC.
A retrospective cohort study was conducted with 18,416 cases entered into the Surveillance, Epidemiology, and End Results Program database between 2004 and 2009. Variables including age, sex, race, tumor grade, size, stage group, TNM stage, and treatment modality of 18,298 SCC patients and 118 SpCC patients were extracted and combined into oral cavity, oropharynx, and larynx sites. Characteristics and survival of SpCC and SCC patients were compared in total and at each site. The effect of variables on survival with SpCC was assessed.
In total, SpCC patients experienced worse survival than conventional SCC patients (
SpCC carries a worse prognosis than conventional SCC when located in the oropharynx. Survival with SpCC was associated with stage group and TNM stage, but was unaffected by sex, race, or grade.
(1) Determine whether tracheoesophageal prosthesis (TEP) use is associated with improved quality of life. (2) Identify factors which negatively correlate with quality of life in patients utilizing TEP.
Cross-sectional analysis of total laryngectomy patients with and without TEP treated at the Michael E. DeBakey Veterans Affairs Medical Center (MEDVAMC). Demographic, tumor, and treatment characteristics were reviewed. Functional status and quality of life were measured using the Voice Handicap Index (VHI), MD Anderson Dysphagia Index (MDADI), and University of Washington Quality of life Index (UW-QOL).
Sixty-one patients were identified, including 27 patients using TEP communication and 34 using either nonverbal communication or electrolarynx. TEP use at time of evaluation was associated with significantly higher VHI (TEP vs no TEP, global:
TEP use is associated with durable improvements in quality of life and functional outcomes for veterans undergoing total laryngectomy. TEP placement should be considered in all total laryngectomy patients when technically feasible.
Determine the efficacy of a swallowing preservation protocol on maintaining swallow function in patients undergoing chemoradiation (CRT) for head and neck squamous cell carcinoma (HNSCC).
Retrospective case-control study of patients treated with CRT for HNSCC between July 2011 and December 2013 at a Veterans Affairs medical center. The study group comprised patients participating in a swallowing preservation protocol, including swallowing exercises and biweekly follow-up, during CRT. The control group received no swallowing intervention during CRT. A previously described functional outcomes of swallowing scale (FOSS; 0 = no symptoms and 5 = nonoral feeding for all nutrition) was used to quantify dysphagia prior to, at the completion of, and 2 months following the completion of CRT.
Forty-eight (all male; mean age, 67 years) and 85 patients (all male; mean age, 61 years) were included in the swallowing preservation and control groups, respectively. In the swallowing preservation group, mean pre- and posttreatment FOSS scores were 2.2 and 1.9, respectively, while the corresponding scores in the control group were 0.92 and 1.0. This approached statistical significance (Fisher’s exact test,
Patients enrolled in a swallow preservation protocol had overall poorer swallowing function at the initiation of CRT, but compared to the control group, a higher fraction of patients in the swallowing preservation protocol maintained or improved their swallow at posttreatment follow-up. This confirms the importance of early evaluation and intervention for dysphagia prior to and during CRT.
Vitamin D deficiency is thought to increase the risk of symptomatic hypocalcemia after thyroidectomy. While often assessed after surgery in patients who develop hypocalcemia, many surgeons do not routinely evaluate vitamin D status preoperatively. This study (1) characterized the frequency preoperatively of vitamin D deficiency in patients undergoing thyroid surgery in the northern United States and (2) identified groups at increased risk of vitamin D deficiency.
Case series with prospectively maintained database at an: academic medical center. Patients undergoing thyroid surgery between January and December 2013 were included. Preoperative 25-hydroxy vitamin D, parathyroid hormone (PTH), and ionized calcium levels were obtained on all patients. Patients with 25-hydroxy vitamin D levels less than 20 ng/mL were considered deficient and were repleted.
Of 110 patients who underwent thyroid surgery during the 12-month study period, 44 (40%) were vitamin D deficient. A total of 33 out of 44 deficient patients had secondary hyperparathyroidism. Black and Hispanic patients (
While select groups are more susceptible, in the northern United States vitamin D deficiency is pervasive in patients undergoing thyroidectomy. Given its impact on postoperative calcium status, surgeons should consider routinely assessing preoperative vitamin D status and, if necessary, supplementation.
Compare functional and survival outcomes between patients with advanced stage head and neck squamous cell cancer (HNSCC) treated with primary transoral surgery versus primary chemotherapy and radiation.
Retrospective case-control trial at an academic tertiary referral center. We identified a surgical group (SG) comprised of 37 patients with previously untreated stage III and IV HNSCC who underwent either transoral robotic surgery (TORS) or transoral laser microsurgery (TLMS) and a nonsurgical group (NSG) of 75 patients treated with primary chemotherapy and radiation between July 2007 and November 2011. NSG was matched to SG by age, sex, tumor location, stage, tobacco and alcohol use, and ECOG status. Tracheostomy and percutaneous gastrostomy tube (PEG) rates during treatment and at follow-up, as well as survival outcomes, were examined.
There were no statistically significant differences in the matched variables. Significantly fewer patients in the SG compared with the NSG still had PEG at follow-up, 8% versus 25%, respectively (
Comparison between the primary transoral surgery and primary chemoradiation groups for treatment of advanced HNSCC demonstrates similar survival outcomes. Patients who undergo surgery receive significantly lower doses of radiation, and most are able to regain functional swallow and be successfully decannulated.
(1) Investigate the impact of programmed cell death ligand 1 (PD-L1) on the response to Cisplatin (CDDP) therapy in head and neck squamous cell carcinoma (HNSCC). (2) Quantify the effect of CDDP treatment on the expression of PD-L1 in HNSCC cells. (3) Evaluate the impact of PD-L1 down-regulation on the chemosensitivty of HNSCC cells. (4) Describe the implications of PD-L1 modulation on the efficacy of current platinum-based chemotherapeutic agents in HNSCC.
In vitro experiments were performed from November 2013 to January 2014 at the University of Pennsylvania Gene and Molecular Therapy Laboratory with 4 well-characterized human HNSCC cell lines. Quantitative polymerase chain reaction (qPCR) and western blot were conducted to determine the baseline and post-CDDP treatment PD-L1 gene expression. Knockdown of PD-L1 expression using siRNA was then performed to induce chemosensitization of HNSCC cells to CDDP. Cells treated with CDDP were compared with untreated controls to evaluate cytotoxicity.
Treatment of HNSCC cells with CDDP resulted in increased transcription and translation of PD-L1 compared with baseline levels. Subsequent knockdown of PD-L1 expression in HNSCC cells using siRNA resulted in increased CDDP cytotoxicity compared with control HNSCC cells.
Increased PD-L1 expression in response to CDDP therapy and improved chemosensitization with its down-regulation are significant findings that highlight the role of PD-L1 in determining the efficacy of chemotherapeutic agents. Our findings demonstrate that disruption of the PD-L1 protein leads to increased sensitivity of HNSCC cells to CDDP, suggesting a potential combination therapeutic strategy for patients with CDDP-resistant HNSCC.
(1) Describe the anatomic location and distribution pattern of glottic dysplasia and early glottic cancer over the vocal folds. (2) Better understand the anatomic locations where glottic carcinogenesis initiates.
A cohort reviewing glottic dysplasia or carcinoma patients, in a referral center, between 2008 and 2013. Lesions were described in terms of location and size, and a novel grid system was used to map their anatomic distribution.
A total of 167 patients were included; 78 with dysplasia and 89 with T1 early glottic carcinoma. The medial aspect was found to be more involved than the superior aspect, 95% versus 71%, respectively (
Premalignant and malignant glottic lesions tend to involve the medial aspect of the vocal fold, and the midpoint of the membranous part in particular. This might correlate with the anatomic origin of glottic carcinogenesis.
Describe the demographics, clinical presentation, interventions, and outcomes of adult patients diagnosed with acute supraglottitis.
We retrospectively identified adult patients with acute supraglottitis during the years 1990 through 2013 by using relevant International Classification of Disease codes. Data were extracted for demographic and clinical information.
A total of 288 eligible patients were enrolled. Diagnosis was made by either indirect or fiber-optic laryngoscopy (or both modalities). The incidence rate of acute supraglottis was 4.3 out of 100,000 patients/year, with a steep rise during the years 1999 through 2013. A slight male predominance was observed (n = 160, 56%). The mean age was 50 ± 16 years, and 77% were 30 to 70 years old. Sore throat (94%) and dysphagia (88%) were the most common presenting symptoms, which had begun 2 days prior to hospitalization. Comorbidities were reported in 62% of the patients. Swabs were obtained in 17% of patients, of those 23% were positive. Patients were hospitalized either in the otolaryngology department (n = 255, 89%) or in the intensive care unit (ICU) (n = 33, 11%). Of the ICU patients, 19 (58%) had an airway securing intervention procedure (84% upon admission, 16% during initial 24 hours surveillance). Amoxicillin-clavulanate was administered in 61% of patients. Intravenous and inhalational corticosteroids were administered in 190 (66%) patients. The mortality rate was 0.003%.
The signs and symptoms of supraglottitis in adults are different from those in the pediatric population. Patients presenting with sore throat, dysphagia, or odynophagia should be cautiously suspected for supraglottitis until proven otherwise. Treatment includes intravenous antibiotics and steroids and outcomes are excellent.
(1) Describe the use of narrowband imaging (NBI) to enhance diagnostic sensitivity and accuracy in an impressive number of patients. (2) Develop a complete description list of each laryngeal condition, which can serve as a criteria for further laryngoscopic examinations and diagnosis.
This study was conducted between January 2012 and October 2013 at the Department of Otolaryngology, the second hospital attached to Jilin University (Changchun Jilin, China). A total of 3675 patients (2092 males, 1583 females; mean age 50.2 ± 19.5 years) were enrolled in this study. All 3675 patients underwent laryngoscopy equipped with conventional white light and NBI system. A total of 1153 lesions were classified into different groups according to their histopathological results.
On NBI view, mucosa of a normal vocal fold was light brown. Intraepithelial vessels displayed blue-green, which were in striking contrast to the surrounding mucosa. Polyps demonstrated a color of light green. Cysts and mucocele appeared as light white. Leukoplakia was shown as a white color and hyperplastic epithelial lesions appeared as a slightly brownish color. Erythroplakia appeared as well-distributed dark brown lesions. Pachydermia displayed light white with a quite different shape from that of cysts. Papilloma were shown as quite delicate green. Abnormal submucosal microvessel changes visualized in laryngeal carcinoma lesions were shown as typical scattered dark brownish spots. Sensitivity and specificity for the diagnosis of malignancy by means of NBI view calculated from these results were 98.81 and 99.89%, respectively.
The advent of NBI is a breakthrough in the field of assessing laryngeal diseases, especially malignant ones.
(1) Determine the diagnostic yield of contrast-enhanced computed tomography (CT) in the evaluation of patients with idiopathic unilateral vocal fold paresis. (2) Determine the proportion of CTs yielding nondiagnostic incidental findings requiring further patient management.
Retrospective cohort. Precision-based power calculations were performed. All patients of the 2 senior authors who underwent contrast-enhanced CT for a clinical diagnosis of vocal fold paresis from January 2004 to January 2014 were included. Demographic, history, examination, and investigation data were extracted from outpatient records and CT reports were reviewed. Patients were excluded if there was insufficient history or examination information, if there was a known neurological diagnosis, or if there was vocal fold immobility or bilateral involvement. A diagnostic CT was defined as depicting a pathological lesion along the course of the ipsilateral recurrent or superior laryngeal nerves. Incidental CT findings were defined as those unrelated to paresis and requiring further intervention.
A total of 128 patients were included in the study. Three out of 128 patients had a diagnostic CT equating to a diagnostic yield of 2.3% (0.49-6.7 95% confidence interval [CI]). Thirty-nine out of 128 patients, or 30.5% (22.6-39.2 95% CI) had an incidental CT finding requiring further management.
Contrast-enhanced CT has a low yield of 2.3% in the initial evaluation of idiopathic vocal fold paresis. Conversely, CT has a high, 30.5% yield of incidental cervico-thoracic lesions. This would suggest that the routine use of CT in the evaluation of idiopathic vocal fold paresis is not warranted.
Some patients with multiple system atrophy (MSA) require surgical management such as tracheostomy and laryngeal closure with the evolution of diseases such as severe dysphagia and/or respiratory disorder. There are few reports about the relationship between dysphagia and vocal cord paralysis (VCP) and about postoperative feeding in MSA patients. The aim of this study is to describe clinical management and outcomes of surgical treatment in MSA patients.
From 2001 to 2013, 16 MSA patients (11 males) underwent surgical procedures. All cases were retrospectively evaluated for vocal fold fixed position, degree of dysphagia, the duration between the onset of dysphagia (or dyspnea) and surgery, and perioperative feeding.
The mean age was 64.3 years (range, 52-76 years). Tracheostomy was made in 9 patients, and laryngeal closure was performed in 11 patients. Four of 7 patients underwent laryngeal closure (LC) 7.5 weeks (2 to 14) after tracheostomy. Eleven patients had severe dysphagia. The bilateral vocal folds were fixed in a median position in 13 patients. The duration from onset of MSA and surgery was 3 to 111 months (median 59 months). All patients with LC were preoperatively unable to take anything from mouth, but postoperatively all of them regained complete/partial oral intake.
In MSA patients, a correlation between dysphagia and VCP is suggested, however it was revealed that dysphagia does not always precede VCP. This study also showed that LC enables patients to take food orally, regardless of severe dysphagia.
The laryngeal adductor reflex (LAR) is readily triggered in healthy, awake humans by delivering a puff of air to the laryngeal entrance via an endoscope passed through the nose into the throat. LAR impairment has been identified (but not well-characterized) in people with amyotrophic lateral sclerosis (ALS) and is highly correlated with dysphagia. We propose to develop a nonsurgical approach for longitudinal investigation of the LAR in mice.
We designed and constructed an elaborate prototype air pulse delivery system for use with mice. The system interfaces with a miniature endoscope that is small enough for oral insertion into the laryngeal entrance and contains a working channel through which calibrated puffs of air can be delivered, synchronized with rate and phase of the respiratory cycle.
We have successfully used this prototype system to evoke and video record (30 fps) the LAR in 10 healthy, C57BL/6 mice under light anesthesia, thus demonstrating proof of concept. Objective quantification of several LAR parameters is currently underway, including total LAR duration, duration of adduction versus abduction phases, and velocity of dorsal angle adduction and abduction.
This study provides novel evidence that mice have an LAR similar to humans and that several parameters of the LAR can be objectively quantified in this small animal model. Additional research will include laryngeal brainstem response (LBR) recordings evoked by air pulse triggering of the LAR to elucidate pathological neural substrates in mouse models of ALS and other human diseases that cause dysphagia.
Objectively describe the change in glottic airflow following unilateral transverse posterior cordotomy for bilateral true vocal fold paralysis based on peak inspiratory flow rate and pulmonary function tests. Evaluate the impact of unilateral posterior cordotomy on voice related quality of life.
Retrospective chart review of 17 patients with bilateral vocal fold paralysis undergoing CO2 laser posterior transverse cordotomy from January 2008 through December 2013 in an academic medical center. Preoperative and postoperative pulmonary function tests were reviewed including the peak inspiratory flow rate (PIF) and maximal inspiratory flow at 50% of forced vital capacity (PIF50). The results of the 30-item voice handicap index (Voice Handicap Index), an externally validated survey, were recorded pre- and postprocedure.
There was a statistically significant (
Unilateral posterior transverse cordotomy for bilateral true vocal fold paralysis results in a 44% improvement in peak inspiratory flow rates. Preoperative pulmonary function tests can be used to evaluate the potential success of cordotomy alone for glottis stenosis. This procedure does not result in any statistically significant change in voice related quality of life.
(1) Describe the changes in esophageal amplitude and swallow duration during an effortful swallow in patients with esophageal pathology. (2) Understand the utility of the effortful swallow in rehabilitation of esophageal dysmotility disorders.
Prospective case control study in which 10 patients referred for esophageal manometry were enrolled. Each participant performed 20 swallow trials (10 effortful and 10 normal) where amplitude and duration of swallow were measured at 4 different sensors (1 striated, 1 mixed, and 2 smooth muscle sites). The effects of the swallow condition (effortful vs noneffortful), sensor site, and sex on esophageal peak pressure and swallow duration were examined.
The study included 10 participants (8 females, 2 males). There were several patients in whom the effortful swallow showed a statistically significant increase in peak swallow pressure or duration of the measured swallow at a particular sensor. This was not consistent across all patients nor across a particular sensor. There were more statistically significant changes in males compared with females.
Despite clear evidence in previous studies demonstrating that volitional manipulation of the oropharyngeal phase of swallowing affects esophageal physiology in healthy individuals, a small study of patients with esophageal pathology is unable to demonstrate similar results. In future studies, we will aim to include a greater number of patients with diagnosed esophageal dysmotility.
Because cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels are found in human vocal fold epithelium, we aimed to (1) assess the prevalence and severity of dysphonia in patients with cystic fibrosis (CF) and (2) compare these with control patient populations.
Voice samples and the Voice Handicap Index-10 (VHI-10) were collected from patients with cystic fibrosis and control patients with and without chronic sinusitis. Voice samples underwent consensus auditory-perceptual evaluation of voice (CAPE-V) assessment by blinded speech-language pathologists. Sinus-related symptoms were assessed using the SinoNasal Outcome Test (SNOT-20). Statistical analysis was performed using unpaired t-tests and one-way analysis of variance (ANOVA).
Thirty-seven patients participated, including 17 with CF, 10 with chronic sinusitis, and 10 healthy controls. Prevalence of dysphonia by VHI-10 criteria was 41% in CF, 20% in chronic sinusitis, and 0% in healthy controls. CF patients had worse VHI-10 scores than healthy controls (
Auditory-perceptual evaluation demonstrated greater severity of dysphonia in patients with cystic fibrosis than in controls. This may identify an area of clinical need as well as an opportunity for improved understanding of the role of CFTR in human voice.
This study explored the selectivity of epimysial stimulation of the larynx using multi-channel electrode arrays. Recruitment curves from electrode channels within the array were compared, focusing on differences between location of the electrode and specific muscle activation.
This was a prospective, nonrandomized acute animal study. Four cats underwent surgical implantation of electrode arrays into the posterior cricoarytenoid muscle. The airway was secured with a tracheostomy, and the glottis was visualized with a 0° 4-mm telescope while individual and combinations of electrodes within the array were stimulated with varying current. Digitized recordings of stimulated vocal folds were analyzed using imageJ and the degree of vocal fold abduction was measured to create recruitment curves.
Electrodes implanted along the medial aspect of the posterior cricoarytenoid stimulated graded physiologic degrees of abduction depending on the amplitude of stimulation current. Electrodes implanted laterally along the posterior cricoarytenoid stimulated greater degrees of simultaneous adduction with abduction. The electrode array allowed mapping of most useful electrode position, so that only one implantation procedure was required to yield good results, thus limiting trauma to the larynx. Electrode arrays with more electrodes were more likely to contain electrodes that were appropriately positioned for optimal abduction.
Acute studies of implanted electrode arrays into the posterior cricoarytenoid produce graded physiologic degrees of abduction necessary for respiration. Further chronic studies are warranted to investigate long term feasibility and durability of this electrode design.
Explore hypopharyngeal exposure to abnormally high or low pH during surgery performed under general endotracheal tube anesthesia and to compare results to published normative 24-hour data.
Twenty volunteers for this prospective cohort study were recruited from June through September 2013. A wireless Dx-pH monitoring system was used during surgery. A drop from baseline to pH <5.5 was defined as a hypopharyngeal event, with thresholds pH 4.0, 4.5, and 5.0 also examined. Results were compared with supine events published by Chheda et al in 2009.
The number and duration of hypopharyngeal events <15 minutes with pH below 4.0, 4.5, 5.0 and percentage of surgery time in hypopharyngeal events (from a pH = 5.5 to return to baseline) were similar to comparative data. However, including all duration events (> ≤ 15 minutes), the number and duration of events at all thresholds and the percentage of surgery time in hypopharyngeal events were consistently higher than comparative data. Most analyses with the potential predictive/confounding variables (ie, body mass index, Reflux Symptom Index, Voice Handicap Index-10) yielded nonsignificant results.
Extended pharyngeal exposure to moderately reduced pH levels (greater than sleeping or resting in a supine position) were documented. Approximately 20% of surgical patients may experience extensive exposure to pH <5.5 (over 1 hour, >30% of surgery time) and an additional 20% may experience moderate exposure to pH <5.5 (5-20 minutes and/or 4% to 10% of surgery time). Additional studies are needed to predict which patients might be at elevated risk for this exposure as well as the impact of this exposure on clinical outcomes.
(1) Perform vocal fold reconstruction using composite thyroid ala perichondrium (CTAP) flaps in beagles following unilateral vocal fold stripping; (2) Evaluate aerodynamic, acoustic, vibratory, and histologic changes in canines undergoing CTAP-based vocal fold reconstruction compared to a control group undergoing injury alone.
Unilateral vocal fold stripping was performed on ten beagles. Dogs healed for 1 month and were divided into 2 groups. Dogs in the control group (n = 5) were sacrificed. Dogs in the experimental group (n = 5) underwent ipsilateral vocal fold augmentation with a CTAP flap and recovered for 1 month prior to euthanasia. After euthanasia, larynges were harvested for excised larynx evaluation of vocal fold vibration using aerodynamic, acoustic, and mucosal wave measurements. Histological analysis was then performed on anterior, middle, and posterior sections of the vocal fold. Changes in the injured fold were compared between the control and experimental groups. Comparisons with the contralateral normal fold were made within the control and experimental groups.
Phonation threshold pressure was significantly lower in the treatment group (
CTAP-based vocal fold augmentation restored glottic closure and vibratory periodicity following vocal fold scarring. Additional investigation on biologic response is warranted. CTAP flaps offer an autologous, vascularized implant that can improve both vocal fold structure and function.
Identifying the inflammatory cells mediating laryngotracheal stenosis (LTS) could allow for identification and modulation of specific immune mechanisms to reduce the development of airway fibrosis. The objective of this study is to (1) introduce a novel mouse model of LTS and 92) define the inflammatory cell infiltrate preceding fibrosis.
The experimental design was a 21-day prospective controlled in-vivo in-situ animal study. The mouse laryngotracheal complex was chemomechanically injured with a bleomycin-coated wire brush. Mice were sacrificed at 7, 14, and 21 days. Specimens were examined using histology to assess mucosal inflammation and fibrosis. Immunohistochemistry (IHC) and gene expression analysis were performed to delineate inflammatory cells. Results were compared with 2 control groups: (1) mice with no tracheal injury; and (2) mice that underwent tracheal injury with a saline-coated wire brush.
Histology demonstrated progressive thickening of the subepithelial lamina propria with an increased inflammatory infiltrate including lymphocytes, neutrophils, and macrophages that peaked at Day 7. This transitioned to resolving inflammation and initial fibrosis by Day 14 with progression of fibrosis to day 21. Gene expression and IHC confirmed increased T-cells and macrophages compared to controls. IHC staining was positive for CD4+ T-lymphocytes.
Chemomechanical injury of the mouse trachea in situ was successful and may be used as a model to study LTS. Bleomycin accelerates fibrosis as compared to controls with saline-coated wire brush injury. Macrophages and CD4+ T-lymphocytes precede the development of fibrosis in this mouse model and should be further investigated as mediators of LTS.
Evaluate the long-term efficacy of laryngeal reinnervation with refined nerve-muscle pedicle (NMP) flap implantation combined with arytenoid adduction for unilateral vocal fold paralysis (UVFP) using laryngeal electromyography (LEMG), coronal images, and assessment of phonatory function.
We retrospectively reviewed 16 UVFP patients who received refined NMP implantation with arytenoid adduction. Videostroboscopy, perceptual evaluation, acoustic analysis, aerodynamic analysis, LEMG, and coronal imaging were performed pre- and 2 years after surgery. For LEMG analysis, a four-point scale was employed to grade motor unit (MU) recruitment where 4+ represented absent recruitment, 3+ represented greatly decreased recruitment, 2+ represented moderately decreased recruitment, and 1+ represented mildly decreased activity with less than full interference pattern. Coronal images were assessed for differences in thickness of the vocal folds during phonation and inhalation.
Phonatory function results were significantly improved postoperatively for all patients. In LEMG findings, preoperative MU recruitment evaluation results were 1 patient for 1+, 5 for 2+, 1 for 3+, and 3 for 4+. Postoperative MU recruitment evaluation results were 7 patients for 1+, 3 for 2+, and none for 3+ and 4+. Thinning of the affected fold was evident during phonation in 15 of 16 patients preoperatively. The affected fold was at an equal volume with the healthy fold in 8 of 16 patients postoperatively.
LEMG findings and coronal imagine demonstrates that refined NMP implantation results in successful reinnervation of laryngeal muscles in UVFP patients. Refined NMP implantation may provide near-normal voice function and restored laryngeal muscle tone and volume.
Determine whether long-term survival of fat implanted into the vocal folds is possible.
Nine patients of those treated between 1992 and 2005 by means of bilateral fat injection into the vocal folds responded the call to assess long term results. Initial diagnosis was unilateral vocal fold palsy (6) and superficial sulcus (3). The graft was obtained by means of dissection of fat from the abdominal wall, and injected with an 18 G needle into the body of the vocal folds until 50% over correction was achieved. In palsy cases a higher fat volume was required on the paralyzed side. All patients underwent laryngostroboscopic examination preoperatively and postoperatively, along with postoperative magnetic resonance imaging (MRI) of the larynx, 4 to 14 years after surgery. As far as MRI is concerned, spine echo and fat-suppressed sequences in axial coronal and sagittal planes were obtained, looking for high intensity areas in T1-weighted images at the level of the vocal folds.
Laryngostroboscopy demonstrated permanent augmentation of the vocal folds with glottic closure improvement. MRI images in all cases showed the presence of enough fat in the body of the vocal folds, acting as support for good size and shape of the structure.
Autologous fat cells injected into the vocal folds can survive years after surgery, acting as a permanent filler. Those conditions are in favor of fat grafts to be used as an inexpensive, easy to use, and long-lasting implant for selected cases of glottic incompetence.
With blue and green light only, narrow band imaging (NBI) allows better visualization of mucosal micro-vascular architecture. Intra-epithelial papillary capillary loops (IPCL) is a classification of vascular patterns based on previous esophageal NBI studies. The aims of the study were to: (1) Study the normal micro-vascular anatomy of the larynx by means of NBI. (2) Better understand the clinical applications of NBI in laryngeal lesions. (3) Assess the relative advantages and disadvantages of NBI versus white light imaging in the larynx. (4) Assess the relevance of previously described IPCL classification in laryngeal pathologies.
A prospective comparative study including patients who arrived for laryngeal examination at an ENT referral center in 2013. White light images and NBI were compared in each patient to assess relative advantages of each modality. Micro-vascular architecture was described by IPCL classification.
A total of 110 patients were included and underwent video-stroboscopy, flexible distal-chip endoscopy, and NBI of the larynx. Thirty-two patients had a normal larynx, 54 had benign conditions, and 24 had malignant lesions. Distinct characteristics of vascular patterns were visualized by NBI in normal tissues, as well as a wide spectrum of benign and malignant conditions. In several patients with malignant and premalignant conditions, NBI revealed more extended disease than what was observed by white light imaging.
Using NBI along with white light imaging, while understanding the unique microvascular fingerprint of each laryngeal pathologic condition, can assist the physician in differential diagnosis. In specific conditions, including malignant and premalignant lesions, NBI can bring better assessment of lesions’ size and extension.
Sulcus vocalis and scars of the vocal folds reduce pliability of the cover impairing vibration. Severity of dysphonia is directly related to magnitude of structural damage. The purpose of surgical treatment is to restore anatomy in order to re-establish function. The aim of the study was to evaluate the effectiveness of microsurgical liberation of scars and placement of fibrin glue implants into the subepithelial space of the vocal folds to improve pliability.
Fifteen patients (age range, 13-69 years) with diagnosis of sulcus and/or scars were classified into 3 groups, according to severity of structural damage: Group 1: Unilateral, localized lesions with minimal subepithelial compromise. Group 2: Sulcus and/or scars with subepithelial fibrosis. Group 3: Severe scarring. Microsurgical liberation of scar tissue and placing of fibrin glue implants were performed. Fibrin glue components are mixed until solidified. An implant is tailored and it is placed into the subepithelial space. All patients were evaluated preoperatively and postoperatively with stroboscopy. Voice quality changes were assessed by means of the Voice Handicap Index 30 questionnaire.
The technique offered significant vibratory pattern and voice quality improvement in group one and better vibratory pattern and moderate voice quality improvement in group 2. In group 3, although some vibratory improvement was achieved, voice quality results were not satisfactory in 4 out of 5 patients.
The technique described is useful for treatment of vibratory impairment caused by sulcus and/or scarring of the vocal folds in which structural damage is limited. In extensive lesions results show little improvement.
(1) Review demographic data collected over a 23-year experience of 686 patients with spasmodic dysphonia (SD) who have been treated with onabotulinum toxinA (onaBTX-A). (2) Compare demographic trends surrounding SD with previously published data.
A retrospective chart review was conducted. A total of 686 patients with SD were treated with 6345 onaBTX-A injections at Mayo Clinic Arizona between 1989 and 2013. Demographic data were compiled and analyzed. Patients were subdivided based on type of SD, presence of vocal tremor (VT), and presence of neurologic disorders. Family history of neurological disorders was also recorded.
In 686 patients, 432 patients were female (63.0%) and 254 patients were male (37.0%). A total of 630 patients (91.8%) were of the adductor type (AdSD) and 56 patients (8.2%) were of the abductor type (AbSD). AdSD patients noted symptom onset and began injections at an older age than AbSD patients (52.5; 60.6 years vs 43.7 years; 50.0 years, respectively). A total of 374 patients (54.5%) had VT, with 355 AdSD patients and 19 AbSD patients. A total of 45 patients (6.6%) had other movement disorders, such as blepharospasm (1.5%), torticollis (2.3%), limb dystonia (1.0%), or oromandibular dystonia (1.8%). Family history of SD was positive in 4 patients (0.6%) and of other dystonias in 9 patients (1.3%).
Spasmodic dysphonia is a chronic and potentially disabling laryngeal dystonia resulting from disrupted motor control of the laryngeal musculature during phonation. This large series adds new insight and contributes to the current literature regarding the clinical scope and nature of SD.
Evaluate the diagnostic accuracy of flexible fiberoptic examinations of the larynx recorded directly onto smartphones using a novel coupling device.
Prospective, blinded study at a tertiary referral hospital. Inpatients requiring laryngoscopy underwent bedside flexible fiberoptic endoscopy. A smartphone was then attached to the endoscope using a novel coupling device and the same examination was recorded. The laryngologist performing the live examination documented their findings on a standardized scoring sheet. A second laryngologist, blinded to the findings of the first, evaluated the recorded examination using an identical scoring sheet.
Eighteen patients were evaluated from July 2013 to January 2014. Evaluation of airway patency was identical (Kappa 1.0,
There is high correlation between laryngeal diagnoses using live flexible fiberoptic laryngoscopy and recordings of those examinations using a coupling device to transfer the recordings on to smart phones. Critical findings such as airway patency and vocal fold motion showed the highest correlation, subjective evaluation of the quality of the mucosa showed more variability.
(1) Describe the effectiveness of current diagnostic modalities in diagnosing upper aerodigestive tract injuries. (2) Recognize the potential complications of rigid endoscopy in trauma patients.
This is a retrospective chart review of patients admitted between January 1998 to May 2008 with penetrating neck trauma in all zones who underwent assessment with physical examination, barium swallow, computed tomography, and/or endoscopy. The sensitivity and specificity of these modalities were calculated and compared.
Physical examination appears to be unreliable due to poor sensitivity in this study. Direct laryngoscopy appears to be more sensitive than flexible laryngoscopy. Bronchoscopy was not frequently performed and 1 patient (2%) had tracheal repair diagnosed with rigid bronchoscopy. Rigid esophagoscopy was performed more commonly than flexible esophagoscopy. Both types of esophagoscopies detected the 2 (4%) esophageal injuries. Computed tomography scan was nonspecific due to presence of subcutaneous air in most patients. Barium swallow had a 100% negative predictive value in our study and did not miss any injuries. There were 5 patients (10%) who had postprocedure symptoms that can be potentially attributed to rigid endoscopy including teeth injury, and upper and lower extremity weakness and paresthesias.
Barium swallow appears to be a reliable study which did not miss any significant injuries. Endoscopic studies, especially rigid ones, carry a risk of C-spine complications that should be recognized in trauma patients.
(1) Critically review the current staging systems of supraglottitis in adults. (2) Suggest a new algorithm for infections involving the supraglottis based on clinical staging considering anatomical subsites and outcome correlation.
We retrospectively identified adult patients with acute supraglottitis during the years of 1990 through 2013 by using International Classification of Disease codes. Patients were graded by using 2 systems: the Scope grading system for epiglottitis, and our new suggested grading system, which relies on the edema in 3 subsites: the epiglottis, the aryepiglottic folds and arytenoids, and the larynx. Those subsites were given the following grades: 0 = no edema, 1 = mild edema, 2 = moderate edema, and 3 = severe edema. Summation of the 3 subsites scores was performed in order to assess the need for airway intervention.
A total of 288 eligible patients were enrolled. Diagnosis was made by either indirect or fiberoptic laryngoscopy (or by both modalities). One hundred seventy-eight patients (62%) had Scope grades of 0 or 1, and 110 patients (38%) had Scope grades of 2 or 3. Of these, 24% required an airway intervention. According to our classification, 236 patients (82%) who had a score of ≤4 were less likely to undergo a securing airway intervention, when compared with the 52 patients (18%) who had a score of ≥5, 4% vs 33%, respectively (
Our new suggested flow chart of decisions is based on an easy grading system, which allows dynamic description of patient progression during sequential examinations, easy information transmission, and decision making.
The office-based use of photoangiolytic lasers may be a viable option in the treatment of Reinke’s edema. We aimed to determine the safety and efficacy of this technique.
We performed a retrospective analysis of patients undergoing office-based laser treatment of endoscopy-proven Reinke’s edema between January 2007 and November 2013. Safety was evaluated by reviewing complications. Efficacy was analyzed by comparing pre- and postprocedural aerodynamic, acoustic, and voice handicap index (VHI) measurements, and by quantifying procedure tolerance. Data were analyzed using paired
Nineteen patients met inclusion criteria. There were no major complications. Phonation threshold pressure decreased after treatment (n = 4; 8.21 ± 2.10 vs 6.69 ± 2.59 cmH2O;
This study represents the largest series of patients undergoing office-based photoangiolytic laser treatment specifically for Reinke’s edema. Our data suggest that this is a safe and effective modality to treat Reinke’s edema, though patient intolerance of the procedure may represent a barrier.
(1) Determine the prevalence of swallowing problems and reported etiologies and (2) understand their impact among United States adults.
The 2012 National Health Interview Survey was analyzed, identifying adult cases reporting a swallowing problem in the preceding 12 months. In addition to demographic data, specific data regarding visits to health care professionals for swallowing problems, diagnoses given, and severity of the swallowing problem were analyzed. The relationship between swallowing problems and lost workdays was investigated.
An estimated 9.44 ± 0.33 million adults (mean age 52.1 years; 60.2 ± 1.6% female) reported a swallowing problem (4.0 ± 0.1%). Overall, 22.7 ± 1.7% saw a health care professional for their swallowing problem and 36.9 ± 0.1.7% were given a diagnosis. Females were more likely than males to report a swallowing problem (4.7 ± 0.2% versus 3.3 ± 0.2%,
Swallowing problems affect 1 in 25 adults annually. A relative minority seek health care for their swallowing problem, even though the subjective impact and associated workdays lost with the swallowing problem are significant.
(1) Describe operative time and materials for a mass-closure endoscopic laryngeal cleft repair technique. (2) Determine swallowing and endoscopic outcomes of this technique.
Case series of children with confirmed diagnosis of type 1, 2, and 3 laryngeal clefts from 2008 to 2013 in a tertiary pediatric aerodigestive program. Interventions: Endoscopic mass cleft closure; pre- and postoperative swallow evaluations. Outcomes: Operative time, number of sutures, laser use, endoscopic findings, aspiration or penetration on postoperative swallow evaluation.
Eighteen patients were studied. Mean age 5.8 ± 4.9 years (range, 0.3-7 years). Sixteen had type I cleft, 1 had type II, and 1 had type III. Four had unilateral or bilateral vocal fold immobility preoperatively. Fifteen underwent functional endoscopic evaluation of swallow (FEES) and/or videofluoroscopic swallow study (VSS) preoperatively; 14 showed laryngeal penetration and/or aspiration. Mean operating time was 76.6 ± 40.9 minutes (range, 43-181 minutes) with a fellow or resident participating in all cases. Operating time was unchanged by laser use (
The endoscopic mass-closure technique is safe, fast, technically straightforward, and produces swallowing outcomes similar to traditional techniques. Postoperative hospital stay is brief, and repairs remain intact over long-term follow-up.
(1) Report the initial dosing for adductor and abductor spasmodic dysphonia (ADSD, ABSD). (2) Identify trends in dosing for patients with SD over extended time.
A retrospective review of the medical records of 149 patients who received 2484 Botox injections from the same physician at a tertiary medical center between January 1993 and December 2012. The location and dose of injection, age of the patient at injection, and the interval in days between injections were recorded.
There were 13 ABSD patients and 136 ADSD patients. The initial dose injected into each vocal fold for patients with ABSD (mean = 2.8 units) was significantly higher than for patients with ADSD (mean = 1.52; t = 4.46;
Analysis of this patient cohort receiving a high number of injections over an extended period of time reveals variable dosing patterns. This may represent subjective differences in patients’ ability to tolerate side effects of Botox treatment. It may also indicate variability in the etiology and pattern of this neurologic disease.
Describe 2 intralaryngeal prostheses (ILP) designed to treat laryngeal sphincter incompetence. Present the development of these new devices and analyze the improvement of swallowing.
Patients presented with moderate to severe swallowing disorders due to neurological disease or after head and neck cancer treatment were included in this study. All patients required a tracheostomy and a feeding tube to fulfill the inclusion criteria. Two ILP were evaluated: (1) a closed silicone prosthesis (CP), Novatech; (2) a silicon open prosthesis cover with a double flow valves (VP), opened during respiration and closed during swallowing (Newbreez, Protip, France). The devices were inserted under endoscopy. The swallowing functions were assessed from postoperative day 2 and scored using the swallowing performance status scale (SPS).
Nineteen patients were included. Eleven patients, presented with neurological disease, received CP. Eight patients suffering from neurological disease (n = 4) or from swallowing disorders after radiotherapy (n = 4) received a VP. CP stopped aspiration in 11 patients, allowing a partial oral feeding in 6 patients and the withdrawal of the prostheses after a partial neurological recovery in 4 patients. VP decreased laryngeal aspiration of food or saliva, allowing to continue partial oral feeding and to speak with a whispered voice.
CP prevents laryngeal aspiration, allowing swallowing reeducation during the phase of neurological recovery. VP is still on assessment in order to propose to patients with moderate swallowing disorders to keep laryngeal phonation and respiration.
(1) Augment surgeon skills through gesture scaling and magnified visualization. (2) Eliminate extensive training using intuitive stylus-based manipulation. (3) Perform active constraints intraoperative planning assisting the surgeon.
The virtual microscope elements system are: Motorized Micromanipulator, Graphics Stylus with Tablet, Virtual Microscope (VM), Configuration Interface (CI). The apparatus has been implemented and tested between July and December 2013 by resident surgeons and medical students. The surgeon performs the surgical tasks in the VM interface, consisting of modified head-mount display and HD cameras attached to a microscope. The CI includes different categories: in-surgery messages, choosing assistive features, system configuration, etc. The assistive features in the VM include: Precise aiming and incision with laser, defining virtual scan patterns allowing incision and ablation planning for automatic execution, defining regions where the laser is active (safe area), or inactive (dangerous area). The apparatus was compared with the state-of-the-art Lumenis AcuBlade (AB) interface. Average path outcome measurements following error and statistical subjective evaluations of usability were made.
The average path following error (root mean square error value) was 0.25 mm while maximum error was 0.66 mm. VM is more accurate and superior to AB, which provided values of 0.51 mm and 1.20 mm, respectively, in earlier trials. The subjective evaluations of usability gave a score of 88.3 for the VM. Earlier trials with AB provided a score of 65.56. VM interface is simple, usable, easy to learn, and appropriate.
The VM was created to provide improved precision, safety, and better ergonomics for microsurgery procedures. The system provides enhanced 3D visualization and allows delicate maneuvers.
The advanced technology of distal-chip flexible naso-endoscope (“chip-on-the-tip” processor), with high resolution digital video recording, allows for more accurate diagnosis, treatment, and follow-up of patients with laryngeal disease. Using this instrument with a working channel introduces a new surgical tool, allowing for a variety of transnasal surgical procedures under topical anesthesia. The aims of the study were to: (1) Describe the spectrum of treatment options for laryngeal pathologies using distal-chip flexible naso-endoscope. (2) Describe the variety of accessories that can be used. (3) Assess the relative advantages, limitations and risks.
A retrospective series reviewing medical files of patients treated with the distal-chip endoscope during 2010 through 2013 for benign laryngeal conditions. Compliance, complications, surgical notes and long term outcome were documented.
Forty-six patients were treated by office-based laryngeal surgery during the study period. Surgeries performed: Diagnostic biopsies of the glottis, subglottis, and trachea and treatment of papillomatosis, fibrovascular lesions, granulation tissue, keratosis, stenosis, vocal cord paralysis, and cysts. Instruments used: anesthesia catheter, grasping forceps, injection needles, and lasers. No significant adverse effects or complications were documented. The only factor influencing procedure success was patient cooperation and ability to resist gag reflex. Most patients had transnasal surgery; few had combined transnasal and transoral procedures.
The distal chip endoscope with a working channel enables the laryngeal surgeon to perform relatively complex procedures as an office-based surgery while avoiding the consequences of general anesthesia and operating room costs.
Office-based laryngeal procedures, vocal fold injections in particular, have become increasingly popular over the past 15 years. The purpose of this study was to examine trends in the use of different vocal fold injection techniques in the United States from 2000 to 2012 and see if they reflect this shift.
The United States Part B Medicare claims database was queried from the years 2000 through 2012. The Current Procedural Terminology codes for indirect laryngoscopy with injection (31513), direct laryngoscopy with injection (31570), and direct laryngoscopy with injection, aided by telescope or operating microscope (31571) were used. For comparison, data for medialization laryngoplasty (31588) were also examined. The volume of procedures performed was tabulated for each code by year.
Over the time period studied, the number of non-operative laryngoscopic injections (31513, 31570) and operative medialization laryngoplasties remained constant. Operative vocal fold injection (31571) demonstrated significant, linear growth over the 12-year study period, from 744 procedures in 2000 to 4788 in 2012, an increase of over 640%.
The dramatic increased incidence in the use of code 31571 reflects an increasing share of vocal fold injections being performed in the operating room and not in an office setting, which runs counter to the prevailing trend within laryngology of awake, office-based injection procedures. This may indicate that these procedures have become more popular over time within the otolaryngology community and are being performed increasingly by providers more comfortable with the controlled operating room setting.
Medialization laryngoplasty is a standard surgical treatment for unilateral vocal fold paralysis (UVFP). This study presents the surgical outcome of thyroid cartilage implantation (TCI), an external medialization laryngoplasty, using thyroid cartilage as the implant.
This retrospective clinical series study aimed to analyze the surgical outcomes and safety of laryngoplasty with TCI for UVFP. Seventeen patients with UVFP who underwent laryngoplasty with TCI were examined preoperatively and at 1, 3, and 6 months postoperatively by video laryngostroboscopy. Their voice was evaluated by subjective evaluation and acoustic analysis.
After surgery, 16 of the 17 (94.1%) patients reported their subjective and objective improvements in voice quality after a follow-up period of at least 6 months. Glottal incompetence and vocal performance were markedly improved after this surgery. There was a significant decrease in voice grading (from 2.47 to 1.29, subjective improvement) (
Laryngoplasty with TCI represents a simple, safe, and effective surgical treatment for UVFP. The advantages include voice improvement, low cost and minimal invasiveness.
Systematic review of literature on patient-reported voice handicap following T1 glottic squamous cell carcinoma treatment using endoscopic surgery or radiation therapy.
PubMed, Web of Science, and Scopus (1988-2013) were searched for papers reporting Voice Handicap Index (VHI) after treatment of early glottic carcinoma. Review and reference cross-checking were performed using a priori selection criteria. Study data were abstracted and publication quality categorized independently by 2 authors. Corresponding authors were contacted to maximize data for analysis. Meta-analysis was performed using a random-effects model.
Twenty-three studies with VHI data following surgery (n = 7), radiation (n = 4), or both (n = 12) were reviewed. Meta-analysis was then pursued with studies that included both modalities. Excluding studies reporting multiple T-stages or systematic treatment selection bias, 5 retrospective cohort studies describing 238 patients in total were suitable for meta-analysis. Depth of excision and follow-up time (mean, 47 months; range, 1-298 months) varied across studies. Three studies showed no VHI difference between treatment arms, 2 favored radiotherapy over surgery (one of which reported transmuscular cordectomy for all surgical patients), and none favored surgery. Meta-analysis slightly favored radiotherapy over endoscopic surgery (mean difference 7.73, 95% confidence interval 0.29-15.16,
Best available evidence was Level 4 with significant heterogeneity. Current literature may suggest lesser patient-reported voice handicap after radiation than endoscopic cordectomy, but the difference is of minimal clinical significance. Prospective randomized studies are needed for greater clarity when counseling patients.
Determine the safety and cost effectiveness of type 1 thyroplasty as outpatient surgery without a surgical drain or post-anesthesia care unit (PACU) observation. Study Design: Prospective cohort study.
Patients with vocal cord immobility (n = 25) were surgically managed with an outpatient type 1 thyroplasty under conscious sedation without a surgical site drain from April 1, 2013, through October 1, 2013. Eighteen of 25 patients were transported directly from the operating room to the nursing unit, completely avoiding the PACU. Historical inpatient controls (n = 25) were included for comparison. Postoperative complications were recorded. A cost analysis was conducted to compare inpatient versus outpatient surgery.
In our series of patients undergoing outpatient type 1 thyroplasty, only 1 of 25 (4.0%) postoperative hematoma was documented. No postoperative complications occurred in the inpatient control group. Outpatient type 1 thyroplasty cost $922 less than overnight surgery. Avoiding the PACU resulted in an additional $550 savings.
Our prospective study demonstrated that outpatient type 1 thyroplasty without a surgical drain is a safe and cost-effective surgery in appropriately selected patients. Furthermore, doing the surgery under light sedation allows the patient to be transported directly to the nursing unit, avoiding the additional cost of the post-anesthesia care unit.
Airway compromise is a common and dangerous presenting sign of ACE-inhibitor–induced angioedema (AIIA). After a definitive airway is obtained, there is minimal evidence-based data for the effectiveness of commonly used medical intervention. While dosing protocols for the treatment of AIIA vary between institutions, they usually contain a corticosteroid, H1-blocker, and an H-2 blocker. The aims of the study were: (1) Define ACE-inhibitor-induced angioedema. (2) Describe common upper aerodigestive subsites of involvement. (3). Discuss the role of corticosteroids in the management of ACE-inhibitor–induced angioedema.
We retrospectively reviewed 200 patient charts from a tertiary care center with diagnosed AIIA to determine the effectiveness of medications utilized in AIIA treatment. These patients were all admitted to the intensive care unit for airway monitoring. The intervention group (n = 100) received high dose steroids, H-1 and H-2 blockers IV. The control group (n = 100) received low dose or no steroids with or without H-1 and H-2 blockers. Outcome measures included length of hospital stay, length of ICU stay, emergent airway intervention, surgical airway intervention, and time intubated.
Preliminary data analysis supports a role for high dose corticosteroids in shortening length of stay (
These findings indicate that there is a role for medical management of upper aerodigestive AIIA with corticosteroids. These findings may ultimately help with the delineation of a standard protocol for AIIA.
Determine the effects of concurrent treatment with the aminoglycoside antibiotic gentamicin and mitoquinone (MitoQ), a mitochondria-targeted derivative of the antioxidant ubiquinone that may protect against aminoglycoside ototoxicity, on mitochondrial function and membrane potential.
This study was prospective and controlled. Mitochondrial membrane potential (MMP) was assessed by flow cytometry using MitoProbeTM JC-1 Kit in untreated PK1 cells and cells exposed to low (100 µM) or high (2000 µM) dose gentamicin for 24 hours, with and without 0.5 µM each of MitoQ or idebenone (an untargeted ubiquinone). Mitochondrial function was determined using the Seahorse XF-24TM flux analyzer.
MMP was not different in untreated cells and cells co-incubated with low-dose gentamicin and MitoQ or idebenone (
The combination of gentamicin and MitoQ holds the potential to disrupt mitochondrial function and membrane potential. This suggests a heightened need to monitor for toxicity in patients receiving both agents.
Determine the effectiveness and side effect profile of antivirals in the treatment of idiopathic sudden sensorineural hearing loss (ISSHL).
We systematically searched the Cochrane Ear, Nose and Throat Disorders Group Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2012, Issue 5), PubMed, EMBASE, CINAHL, and other databases to June 12, 2012. Reference lists of identified studies for further trials were also scanned. Selection criteria: Randomized controlled trials (RCTs) comparing different antivirals versus placebo (both with or without other treatment). Two authors independently extracted data. Meta-analysis was considered inappropriate and ultimately not possible due to differing treatment protocols and differing inclusion criteria and outcome measures between studies.
Four RCTs (257 participants) were identified. Two trials compared the addition of intravenous acyclovir with a steroid (prednisolone). Neither demonstrated any hearing improvement with ISSHL. Another showed no benefit with the addition of valacyclovir to prednisolone on hearing outcome. Comparing intravenous acyclovir plus hydrocortisone with hydrocortisone alone, the final trial did not show any statistically significant difference between groups. Even though no meta-analysis was possible, evidence from 4 RCTs has demonstrated no statistically significant advantage in the use of antivirals in the treatment of ISSHL.
There is no evidence to support the use of antiviral drugs in the treatment of ISSHL. Further randomized controlled trials are needed for adequate meta-analysis to be performed to reach definitive conclusions. A uniform definition of ISSHL should also be established, together with what constitutes adequate recovery.
Compare the microbial flora of adenoids from patients with recurrent acute otitis media (AOM) and patients with obstructive sleep apnea (OSA).
This study was prospective and controlled. Adenoids were obtained from children undergoing adenoidectomy for recurrent AOM or OSA. Specimens were processed for total deoxyribonucleic acid (DNA) isolation; 16s DNA 454-pyrosequencing was performed on AOM (n = 5) or OSA (n = 5) specimens.
All adenoid specimens had evidence of microbes.
Microbes are present on all adenoid specimens, however, the microbial profile differs between recurrent AOM and OSA. The clinical significance of these differences remains to be determined.
Investigate the horizontal vestibulo-ocular reflex (VOR) by means of vHIT in peripheral vestibular disorders.
Prospective clinical trial at a university hospital. Using 2 vHIT equipments (Otometrics(R) and Ullmer(R)), and the caloric response as gold standard, we examined the VOR in a group of 73 patients, and a control group of 18 healthy subjects. The group of patients included BPPV (n = 26), vestibular neuritis (VN) (n = 12), Ménière’s disease (MD) (n = 10), and idiopatic vestibulopathy (IV) (n = 25).
An abnormal VOR gain (less than 0.60) was found in 70.4% of all cases, whereas healthy subjects showed a normal gain in 94.44% of cases. An abnormal vHIT was found more commonly in VN (91.66%) and MD (80%),
The vHIT detects abnormal VOR changes in the combination of gain assessment and refixation saccades. vHIT might be a good screening tool to assess vestibular disorders, avoiding caloric stimulation in certain patients.
Determine if (1) increased body mass index (BMI) is associated with spontaneous cerebrospinal fluid leak (SCSFL) of the temporal bone when compared with NSCSFL; (2) if body mass index (BMI) is a prognostic factor in the management of SCSFL; (3) if aberrant arachnoid granulations and empty sella are associated with SCSFL when compared to NSCSFL.
Retrospective chart review of patients from 2002 to 2013 of all patients treated for CSFL.
Eighteen patients were treated for SCSFL and 17 for NSCSFL between 2002 and 2013. The mean BMI of the SCSFL group was 32.86 (median 33.53). The mean BMI of the NSCSFL group was 28.54 (median 29) (
Patients with SCSFL of the temporal bone have an elevated BMI when compared with NSCSFL. The presence of arachnoid granulations and empty sella on diagnostic imaging is associated with SCSFL when compared to NSCSFL. Patients with SCSFL requiring multiple interventions demonstrated a higher BMI than those treated successfully with a single intervention, indicating that this may be a poor prognostic factor.
(1) Describe the canal wall reconstruction with mastoid obliteration (CWR/MO) technique, (2) understand the benefits for eradication of cholesteatoma, and (3) assess for poorer outcomes in smokers.
Retrospective study analyzing the results of CWR/MO in 82 adult subjects at a tertiary referral center between 2006 and 2013. Subjects were 19 to 79 years old (mean, 44 years) and underwent CWR/MO for either primary or recurrent cholesteatoma. Subjects were re-evaluated with a second look tympanoplasty at least 6 months later. Long-term follow up ranged from 6 to 96 months (mean, 33 months). Fisher’s exact test was employed for significance.
Twenty-one of 82 subjects (26%) had residual cholesteatoma on second look, including 10 of 29 smokers (34%) and 11 of 53 nonsmokers (21%) (
CWR/MO is an alternative to CWD without creation of a mastoid bowl. A second look is recommended to eliminate any residual/recurrent disease. This technique resulted in an overall recurrence rate of 15%, comparable to the CWD technique. Despite a trend towards increased recurrent disease in smokers, this did not reach significance.
Evaluate the contralateral ear (CLE) audiometric findings in patients with middle ear cholesteatoma. (2) Correlate the audiometric thresholds to videotoscopic findings.
Cross-sectional study. Videotoscopies and audiometries of 300 patients with cholesteatoma at a tertiary hospital were analyzed. The CLE videotoscopy, bone conduction, air conduction, and air-bone gap pure tone average (PTA) were analyzed.
The mean patient age was 32.35 ± 19.26 years, and 52.2% were female. The CLE was abnormal in 60.8% of cases: 5.6% had perforation, 39.9% had moderate or severe retraction, and 15.6% had cholesteatoma. The CLE bone conduction PTA was 16.75 ± 16.1 dB, the air conduction PTA was 47.1 ± 22.8 dB, and the air-bone gap PTA was 32.2 ± 18.7 dB. The CLE prevalence of severe and profound sensorineural hearing loss was 1.7%. Severe hearing impairment did not occur in patients with a normal CLE, whereas it did occur in 2.7% of patients with an abnormal CLE (
In patients with cholesteatoma, the CLE had a high prevalence of abnormalities and hearing impairment. Severe and profound sensorineural hearing loss was only observed in abnormal CLE. The air bone gap and air conduction PTA were also higher in the abnormal CLE.
(1) Investigate the association between magnetic resonance imaging (MRI) findings of Chiari Type I malformation and symptoms of dizziness in patients presenting to a neurotology clinic. (2) Recommend indications for intervention for Chiari Type I malformation in patients presenting with dizziness.
A retrospective chart review was conducted for 16 patients presenting to our neurotology clinic between 2002 and 2009 found to have Chiari Type I malformation on MRI. All patients presented with symptoms of disequilibrium and/or vertigo. Charts were reviewed for demographics, symptoms, surgical procedures, videonystagmography, and degree of malformation based radiographic measurements.
The prevalence of Chiari Type I malformation in patients presenting to the neurotology clinic with dizziness is 16 out of 6427 (0.2%). During this time period, 16 patients were found to have radiographically confirmed Chiari Type I malformations. The mean herniation was 6.3 mm with a range of 5 to 13mm. Videonystagmography testing was done on 12 out of 16 patients and 7 out of 12 were abnormal with a mean RVR of 38%. Two of 16 patients (12.5%) underwent posterior fossa decompression. Surgical patients tended to have more severe symptoms.
A small subset of patients who present to neurotology clinics with vertigo and/or disequilibrium will have radiographic findings of Chiari Type I malformation without the traditional symptoms of headaches and neurologic disturbances. The dilemma for clinicians is to determine if the radiographic findings are contributing to the patients symptoms or are an incidental finding. Intervention should only be considered if the herniation is greater than 10 mm, a cervical syrinx is present, or patients have the classic Chiari-type symptoms.
Determine the characteristics of the auditory central gain due to bilateral hearing deprivation, and its relationship with circadian variations as a function of cortical activity.
The study was designed as a prospective observational research, in a national referral center. A total of 28 volunteers ranging between 18 and 30 years old underwent bilateral earplugging with Merocel, previous medical examination, anthropometry, author developed questionnaire, Hamilton anxiety and depression inventory, speech and pure tone audiometry, tympanometry and middle ear reflex (MER), distortion products otoacoustics emissions input/output(DPOAE-I/O), and uncomfortable loudness levels (ULLs) in 0.5-4 kHz. Subjects were randomly divided in 2 groups: Group A, starting at 8:00
We observed an air conduction drop in right ears (AD) at 1 kHz (
We report an association between the increase of serum cortisol and auditory gain and an indirect relationship with normal cortical activity. Thus, bilateral hearing deprivation can potentially be used as a convenient model for the study of hyperacusis.
(1) Compare hearing status of HIV-exposed newborns with HIV-unexposed newborns and (2) determine the association between their hearing threshold and maternal and newborn laboratory parameters.
A cohort audiometric study of newborns in secondary and tertiary hospitals between October 2012 and September 2013. Subjects studied: Consecutive 126 HIV-exposed and 121 HIV-unexposed newborns. Interventions: Hearing screening and thresholds of the newborns were done with Auditory Brainstem Response and compared against maternal highly active antiretroviral therapy (HAART), CD4 cell counts, RNA viral loads, and newborn CD4 percentage. Outcome measurements: Hearing threshold levels of both groups were measured and analyzed using appropriate statistics.
A total of 9.5% of HIV-exposed and 5% of unexposed newborns had hearing impairment (
There was a trend toward more hearing loss in HIV-exposed newborns and a significant difference between the hearing thresholds of HIV-exposed newborns with CD4 % of ≤25 and >25. There is a significant association between newborn hearing threshold and mothers’ viral load. This background information supports the need for further study on the role of in-utero exposure to HIV and HAART in newborn hearing loss.
Creation of an atraumatic, hearing-preservation cochleostomy is integral to the future of minimally invasive inner ear surgery. Current techniques generally take 1 of 2 approaches: mechanical or thermal. The goal of this study was to develop and characterize a novel chemical approach to cochleostomy.
Experimental animal study in which phosphoric acid gel (PAG) was used to decalcify the otic capsule in 25 Hartley guinea pigs. Five animals in each of 5 groups were studied: (1) mechanically opening the auditory bulla alone, (2) PAG thinning of the basal turn otic capsule, leaving endosteum covered by a layer of bone, (3) micro-pick manual cochleostomy, (4) PAG chemical cochleostomy, exposing the endosteum, and (5) combined PAG/micro-pick cochleostomy, with initial chemical thinning and subsequent manual removal of the last osseous layer. Preoperative and postoperative auditory brainstem responses and otoacoustic emissions were obtained at 2, 6, 10, and 16 kHz. Hematoxylin and eosin stained paraffin sections were compared.
Surgical and histologic findings confirmed that application of PAG provided reproducible local bone removal, and cochlear access was enabled. Statistically significant auditory threshold shifts were observed at 10 and 16 kHz following cochleostomy using PAG alone (group 4), and at 16 kHz using manual cochleostomy (group 3) (
Hearing preservation cochleostomy can be performed in an animal model using a novel technique of thinning cochlear bone with PAG and manually completing cochleostomy.
Evaluate the accuracy of diffusion-weighted imaging magnetic resonance imaging (DWI-MRI) in diagnosis of cholesteatoma and the planning of surgery in our hospital.
We conducted a retrospective study of all patients who had cholesteatoma surgery in our hospital from November 2007 until September 2013 that had undergone a DWI-MRI previous to the surgery.
A total of 24 patients were found. A total of 22 DWI-MRI findings were correctly correlated to findings in operation. There was 1 false positive where cholesteatoma was identified on imaging and mucosal disease was found in surgery; and 1 false negative that failed to identify a small cholesteatoma found during surgery. Of the 22 accurate correlations, 4 were of mucosal disease and the rest were correctly diagnosed as cholesteatomas. The DWI-MRI was able to localize the location of the cholesteatoma (from middle ear, attic, mastoid, aditus, hypotympanium and Eustachian tube) in 78% of the cases (14/18).
DWI MRI is highly sensitive in the identification of the presence of cholesteatoma. Negative findings should be followed up because imaging sequences can miss cholesteatomas smaller than 3 mm. There is still a learning curve in the diagnosis and use of DWI MRI.
In clinical practice, knowing the epidemiology of dizziness is essential. The aim of the study was to estimate the prevalence of dizziness among the adult population of the city of São Paulo, Brazil and describe the clinical features and level of discomfort.
A cross-sectional epidemiological survey was conducted in São Paulo, Brazil between April and October 2012. In this field study, 1960 household interviews were completed. The following variables were assessed: sex, age, clinical characteristics of dizziness, and dizziness disability index. Chi-square test, Student
The dizziness prevalence was 42%. Among 2 age groups, peaks of dizziness were observed: 49% among the 46 to 55 years old and 44% among the elderly subjects (>65 years old). Vestibular vertigo was estimated in 8.3% with a strong female preponderance (
The prevalence of dizziness in São Paulo, Brazil, was established in 42%. Among the symptomatic subjects, 67% reported interruption of daily activities, but only 46% of them sought medical attention.
Determine if widely available solutions can effectively kill ticks that may be found in the human ear canal.
This study was prospective, controlled, and blinded. Lone star ticks (
Acetone killed ticks most rapidly (nymph mean time, 185.1 s; adult mean, 562.9 s). Isopropanol 70% (nymphs, 328.9 s; adults, 1128.4 s) and ethanol 95% (nymphs, 294.0 s; adults, 1129.4 s) took longer to kill the ticks. All ticks treated with 4% lidocaine survived. These differences were significant (nymphs,
Acetone is the most effective of the tested, commonly available solutions to kill ticks in the ear canal.
Determine the safety and efficacy of SPI-1005, a novel oral glutathione peroxidase (GPx) mimic and inducer, in preventing and treating noise-induced hearing loss (NIHL) in adults ranging from slight hearing loss (≤25 dBHL) to normal hearing.
Randomized double blind placebo controlled Phase 2 clinical trial conducted December 2012 through November 2013. A total of 83 subjects at the University of Florida were enrolled and treated with either placebo or SPI-1005 prior to a single iPod sound exposure lasting 4 hours that induced a slight temporary threshold shift (TTS). The incidence (≥10 dBHL), severity (dBHL), and duration (up to 1 week post sound) of the TTS were determined by serial pure tone audiometry. The intervention (200, 400, or 600 mg SPI-1005 twice daily × 4 days) was compared with matching placebo in reducing the TTS. Significance was determined by 2-tailed
Oral SPI-1005 treatment showed a significant reduction in TTS incidence (60% vs 20%,
SPI-1005 treatment demonstrated clinically relevant reductions in TTS induced by loud sound exposure. Multiday treatment with all SPI-1005 dosages was well tolerated. These data support the continued development of SPI-1005 in noise exposed populations and the GPx mechanism of action in preventing and treating NIHL.
Determine the effect of L-N-acetylcysteine (LNAC) on gentamicin (GM) initiated vestibulotoxicity.
Wistar rats were divided into 4 groups: Group A (n = 7) had intratympanic (IT) GM (20 mg in 40 µL); group B (n = 6) had IT GM and intraperitoneal (IP) LNAC (350 mg/kg) at 24 hours and 1 hour before GM administration; group C (n = 6) had IT GM and IT LNAC (5 mg in 40 µL); and group D (n = 6) had only IT saline (40 µL). Rats were tested by ABR and cervical vestibular evoked myogenic potentials (VEMP) pretreatment, and at 1 week and 1 month posttreatment. Morphological analysis of the inner ears was performed at 1 month. Main outcome measures were the mean change in VEMP P1 latency at sound stimulation from 80 to 110 dB SPL, and hair cell count in the saccule.
Rats treated with IT LNAC exhibited the least change in mean VEMP latencies, although the intergroup differences were not statistically significant except for 80 dB stimulation at 1 week posttreatment. IP and IT LNAC resulted in preservation of the VEMP response in all rats, whereas 42% of rats not receiving LNAC had absent responses. Morphological analysis of the saccule revealed lower mean hair cell counts in rats not receiving LNAC.
Systemic and IT administration of LNAC of rats treated with GM resulted in minimal variations in VEMP latencies and greater preservation of vestibular hair cells. The protective effect of LNAC in GM-initiated vestibulotoxicity is promising and warrants further research.
Evaluate the efficacy of combined anti-staphylococcal and anti-pseudomonal preoperative antibiotics for preventing surgical site infections following tympanoplasty with mastoidectomy for contaminated cholesteatoma.
Retrospective chart review of medical records of patients who underwent tympanoplasty with mastoidectomy for cholesteatoma were reviewed. Only cases considered to have contaminated or dirty/infected surgical fields were included. The primary outcome measure was postoperative perichondritis, pinna abscess, periotic cellulitis, and periotic abscess requiring systemic antibiotics or surgical intervention.
Charts of 362 patients who underwent tympanoplasty with mastoidectomy were reviewed, and 195 met inclusion criteria. Preoperative antibiotics included single doses of clindamycin and ceftazidime or gentamicin prior to incision. Patients that received no preoperative antibiotics had an infection rate of 11% and those given perioperative antibiotics had a rate of 1% (
Use of preoperative antibiotics covering both staphylococcus and pseudomonas species appears to be efficacious for the prevention of surgical site infections following tympanoplasty with mastoidectomy for contaminated cholesteatoma.
(1) Describe 10 cases of posterior fossa encephaloceles. (2) Compare spontaneous posterior fossa encephaloceles to the more common middle fossa encephaloceles.
This is a retrospective review of patients with surgically-confirmed encephaloceles of the posterior fossa managed at a tertiary care center from 2006 to 2013. Clinical presentation, imaging, and operative findings were reviewed. Patient demographics were summarized with descriptive statistics.
Ten cases of surgically confirmed posterior fossa encephaloceles were identified. The median age of diagnosis was 45.5 years; 6 subjects were female, 4 were male. The median length of follow-up was 18 months, with 2 subjects lost to follow-up. Seven of 10 cases followed temporal bone surgery, craniotomy, or trauma. The remaining 3 out of 10 were spontaneous. Two of 3 subjects with spontaneous encephaloceles presented with pneumocephalus and 1 with cerebrospinal fluid otorrhea. Computed tomography scans in all cases showed bone loss and soft tissue protrusion from posterior fossa into the mastoid, with a radiologic differential of arachnoid granulation versus encephalocele. At surgical exploration, there was brain tissue protruding from a defect of the posterior fossa in all cases. One subject had a concomitant tegmen defect.
Posterior fossa encephaloceles are much less common than middle fossa encephaloceles, only 23 have been reported to date. The difference is presumably due to intracranial pressure differences in the upright position. Given the location of these 3 spontaneous posterior fossa defects, as well as intraoperative findings of cerebral tissue within the mastoid, we suggest that these lesions are true encephaloceles and not just arachnoid granulations.
(1) Describe basic and essential surgical steps of the endoscopic-assisted approach to stapedotomy. (2) Analyze advantages and disadvantages of the endoscopic technique. (3) Compare the outcomes of the endoscopic-assisted stapedotomy with those obtained with the traditional microscopic approach.
The study was conducted from September 2011 to September 2013 at the ENT University Unit of the “A. Fiorini” Hospital, Sapienza University of Rome. Thirty patients (average age 47.5 years, 11 males, 19 females, 30 ears) with clinical otosclerosis undergoing stapedotomy under general anesthesia were enrolled in this prospective, controlled trial. Patients were randomly divided into 2 groups. Group A patients underwent stapedotomy under endoscopic viewing, whereas in Group B the same procedure was traditionally performed using a surgical microscope. The endoscopic set, originally used for endoscopic sinus surgery, included a 3 mm 0° endoscope, a 3CCD camera, and a video monitor. All procedures were performed by the same surgeon and the surgical steps were recorded. Videos were analyzed to compare the details of the anatomical structures in the operative field. Surgical times, functional results, and complications were recorded.
Functional results were comparable in both groups (air-bone gap ≤20 dB). No complications occurred. Surgical times were significantly longer in Group A (
Endoscopic stapedotomy is a feasible, viable alternative to traditional stapes surgery performed with the microscopic approach. The use of endoscopes improve the visualization of the operative field and allow a detailed view of the anatomical structures in an educational perspective.
Cochlear implant is traditionally performed using a mastoidectomy, posterior tympanotomy and cochleostomy using a surgical microscope. Because of the anatomical and physiological understanding of the mastoid cells and their role in maintaining ventilation and pressure equalization in the middle ear, and the possible risk of facial nerve injury, some techniques without mastoidectomy and without posterior tympanotomy have been introduced as an alternative approach, showing excellent results. The aim of the study was to describe totally endoscopic technique without mastoidectomy in 6 patients with bilateral profound hearing loss who underwent cochlear implantation from January 2012 to February 2013, showing its viability and the advantages and disadvantages.
All cases were selected based on computed tomography, magnetic resonance, audiological tests and psychological evaluation. Surgical steps, intra- and postoperative complications were analyzed. Each procedure duration was recorded. Surgical procedure was described step by step focusing on the anatomy of the round window (RW) niche.
The mean duration of the procedure was 62 minutes. No facial nerve injury was observed. All cases showed a normal RW conformation and endoscopic cochleostomy was conducted. No difficult insertion of the IC electrode was observed. The longest follow-up is 2 years. No postoperative complications were observed in this series.
Totally endoscopic cochlear implantation is safe and allows a direct approach to the RW and cochlea. A larger series is paramount to evaluate its total benefits and may represent a breakthrough in the ongoing process of developing scientific knowledge.
Report surgical management and outcomes among a large cohort of patients with glomus tympanicum (GT) managed by a single tertiary referral group over 4 decades.
Retrospective chart review evaluating all patients that underwent surgical treatment of histopathologically confirmed GT between 1973 and 2013. Pre- and postoperative audiometric outcomes were reported according to American Academy of Otolaryngology—Head and Neck Surgery reporting guidelines and tumor stage was described using the Glasscock-Jackson classification system.
A total of 114 patients (90.2% female, mean age 54.0 years) met inclusion criteria. Eleven cases were referred following recurrence, while the remaining 103 patients were treated primarily; 38 (33.3%) GTs were stage I, 52 (45.6%) stage II, 9 (7.9%) stage III, and 15 (13.2%) stage IV. A total of 105 (92.1%) patients underwent gross total removal, while 9 (7.9%) received subtotal resection for advanced disease adherent to the carotid artery and/or facial nerve. Two patients who underwent gross total resection experienced transient facial paresis and one suffered internal carotid injury with stroke. No patients have recurred at a mean follow-up of 39 months.
Surgical approach and extent of resection should be tailored to the patient. Gross total resection can be obtained in over 90% of patients, however leaving adherent tumor remnant on the facial nerve or carotid artery should be considered in patients with advanced infiltrative disease in order to prevent unnecessary morbidity. Microsurgical resection remains the treatment of choice for GT providing a high rate of tumor control and improvement in audiologic symptoms.
(1) Compare the expression of HDAC2 in peripheral blood mononuclear cells (PBMC) of refractory sudden sensorineural hearing loss (SSNHL) patients before and after intratympanic methylprednisolone perfusion (IMP). (2) Identify the relationship between the level of HDAC2 and the prognosis of patients.
Twenty cases of refractory SSNHL patients were selected as therapy group and 10 volunteers were chosen as control group. All 20 SSNHL patients received one course of routine therapy or more, including GC, vasodilator, and neurotrophins. SSNHL patients-PBMCs were collected in the morning before and after IMP, while volunteers were collected on the second day in hospital from January 2013 to September 2013. After therapy, the 20 SSNHL patients were divided into 2 groups (GC sensitive group and GC insensitive group) according to their hearing recovery. Real-time polymerase chain reaction and HDAC2 Assay Kit were used to detect the expression level of HDAC2 mRNA and amount of HDAC2 protein in PBMCs. The data were analyzed with SPSS 17.0 software.
Before intratympanic methylprednisolone perfusion, the level of HDAC2 protein were significantly depressed in all SSNHL patients (F = 13.291,<.0001), while the HDAC2 mRNA expressing much higher than the control group (F = 6.047, =.007). The expression level of HDAC2 mRNA increased significantly after intratympanic methylprednisolone (GC sensitive group:
Knockdown of HDAC2 expression induces corticosteroid insensitivity. Glucocorticoids can increase the expression of HDAC2 mRNA. HDAC2 can be down-regulated by posttranslational modifications.
(1) Review the results of patients undergoing Envoy Esteem implantation from December 2010 through December 2013. All procedures were performed by the same senior surgeon (S.J.M.). (2) Analyze results following implantation of the Envoy Esteem System to determine if patients achieved statistically significant improvement in pure tone average (PTA).
Patients undergoing implantation at Loyola University Medical Center were analyzed regarding preoperative, postimplantation audiometric data, complications, infections, and revision surgery. Study design: Institutional review board approved, retrospective study.
A total of 109 Esteem related procedures were performed. Seventy-one primary implants were performed. A total of 51 were male and 20 were female. A total of 29 revision cases were performed. Additionally, 9 patients were explanted and 9 cases were aborted prior to implantation. The average age of the implant population was 62.8 years old. The average length of follow-up was 20 months. A total of 43 primary implant patients had sufficient data available for analysis. The mean preoperative PTA was 63.4 dB and the mean postoperative PTA was 50.7 dB. Patients demonstrated a 9.90 dB average increase in PTA. A paired
Initial results of The Envoy Esteem system demonstrated a significant hearing benefit in our study population. The revision surgery rate of 26.6% is concerning and patients need to be aware of this potential issue.
Inflammatory bowel disease (IBD) has many characteristics of autoimmune diseases. Sensorineural hearing loss has been reported in many autoimmune diseases. Little is known about hearing loss in patients with IBD.
A prospective blinded comparative study was conducted over a 3-year period. IBD patients and controls underwent a complete otolaryngology examination and audiometry test.
A total of 105 participants (76 patients and 29 controls) took part in this study. A total of 59 (77%) had Crohn’s disease (CD) and 17 (23%) had ulcerative colitis (UC). Mean age was 36 years, 51% were males and 40% of the patients were presently hospitalized due to IBD exacerbation. Sixteen of 76 (21%) of the IBD patients complained of hearing loss since first IBD diagnosis and 13% had current hearing disabilities. Audiometric examination revealed that any hearing loss (mild to severe) was found in 23 (30%) of the IBD population, compared with 3 (10%) of the control group (
Sensorineural hearing loss may be another EIM of IBD. It is found in 30% of IBD patients, and in up to 43% of patients with other EIMs. Early hearing evaluation should be recommended to IBD patients who have other EIMs.
Optogenetics is a powerful new tool to use for the auditory system and involves the introduction of a light-sensitive protein into neurons. This exciting approach may help to increase spatial resolution of auditory implants that are limited due to electrical current spread and to improve outcomes. Herein, we describe: (1) generation of a novel transgenic mouse expressing channelrhodopsin-2 (ChR2+) in spiral ganglion cells (SGC), (2) auditory responses to optical stimulation of the cochlea in our ChR2+ transgenic mouse.
A left cochleostomy was performed and the right inferior colliculus (IC) was exposed via craniotomy in adult ChR2+ mice. Optically evoked auditory brainstem responses (oABRs) and IC multi-unit recordings were conducted in response to optical stimulation via a blue-light laser fiber (473nm wavelength) placed into the cochleostomy. The expression of ChR2 in cochlea was histologically identified under confocal microscope.
ChR2 expression was observed in the soma, the peripheral and central axons of almost all SGCs in 1 to 7- month-old ChR2+ mice. A single 1-ms blue light pulse can evoke oABRs with peak magnitudes up to 10uV and latencies short as 2 ms. Evoked multi-unit activity (~180 spikes/second) in the IC was substantially synchronized (0.9 synchronization index) to a 28-Hz light pulse train applied in cochlea.
We generated and characterized a novel ChR2 transgenic mouse line that is sensitive to light-based stimulation in the peripheral auditory system. Our study may demonstrate the feasibility of using optogenetic technology as the basis for new neuronal stimulation paradigm for cochlear implants.
(1) Test the efficacy of a novel topical growth factor (GF) treatment, delivered by a bioabsorbable polymer, in animal models of chronic tympanic membrane (TM) perforation, Eustachian tube (ET) obstruction, and chronic suppurative otitis media (CSOM). (2) Describe the preclinical work forming the basis for a proposed clinical trial of topical GF treatment.
Bilateral chronic TM perforations were created in our novel mouse model (n = 50) and stable at 3 months, using an inhibitor of epidermal growth factor receptor. One ear received topical GF polymer treatment and the other received polymer only. Another mice cohort (n = 42) had chronic perforations created and also surgical obstruction of the ET. A further mice cohort (n = 35) had CSOM created through the above procedure and inoculation of pseudomonas aeruginosa. These perforations and treatments were evaluated microscopically, histologically, and using cytokeratin immunohistochemistry. Toxicity and safety of our polymer and GF were evaluated using auditory brain stem responses (ABR) and otoacoustic emissions (OAE) at 8 weeks following treatment.
In the chronic TM perforation cohort, 92% (22 of 24) healed compared with 38% (10 of 26) of controls (polymer only) at 4 weeks (
We demonstrate the efficacy, safety, and nontoxicity of a novel GF treatment in animal models.
(1) Examine the efficacy of quick-setting, hydrophilic formulation of hydroxyapatite cement (HAC) used in cranioplasty for the prevention of cerebrospinal fluid (CSF) leaks and long-term wound complications following translabyrinthine acoustic neuroma (TLAN) surgery. (2) Review evolution of HAC cranioplasty.
Retrospective case review from 2006 to 2013 in atertiary referral center. Consecutive patients undergoing translabyrinthine approach for acoustic neuroma tumors were operated on by the senior author. Intervention: Therapeutic: Cranioplasty combining a medial abdominal fat graft with hydrophilic hydroxyapatite cement filling the mastoid. Main outcome measures: Incidence of cerebrospinal fluid (CSF) leaks and any wound complications.
Forty-four patients met inclusion criteria. There were no CSF leaks or other wound complications in this series.
Hydrophilic HAC appears to be safe and efficacious for cranioplasty following translabyrinthine acoustic neuroma surgery.
(1) Describe hearing preservation rates following microsurgical excision of vestibular schwannoma (VS) via middle cranial fossa (MCF) approach. (2) Evaluate long- term hearing outcomes after hearing preservation.
This is a retrospective case series of patients with VS who underwent resection via a MCF approach between February 1998 and December 2009 at a tertiary care academic medical center. Audiograms including pure tone average (PTA) and word recognition score (WRS) were obtained preoperatively, immediately postoperatively, and at 5-year follow-up.
Sixty patients underwent MCF during the study period. Preoperative serviceable hearing (American Academy of Otolaryngology—Head and Neck Surgery class A/B) was present in 52 (86%) of the 60 subjects, with an average PTA of 22 dB (range, 1-50 dB) and an average WRS of 97% (range, 76-100%). Immediate postoperative serviceable hearing was maintained in 29 (55%) of the subjects, with an average PTA and WRS of 31 dB (5-50 dB) and 96% (70-100%), respectively. Five-year follow-up was obtained for 18 of the 29 subjects. After 5-year follow-up, 14 (78%) of the 18 subjects maintained serviceable hearing with an average PTA and WRS of 33 dB (4-49 dB) and 95% (84-100%), respectively. Of the 4 patients who did not maintain class A/B hearing, average change in PTA and WRS was 17 dB (5.5-23 dB) and 16% (0%-40%), respectively. The patient with the most dramatic change in 5-year hearing had a tumor recurrence.
For patients with VS in whom serviceable hearing is preserved following MCF approach, the long term hearing outcome remains durable in the majority of patients.
(1) Describe the use of total ossicular reconstruction prostheses (TORP) during revision stapedectomy in the setting of advanced incus erosion. (2) Analyze the short- and medium-term audiometric results of TORP for revision stapedectomy.
A retrospective case review at a tertiary neurotological referral center was conducted of nineteen cases of revision stapedectomy where TORP reconstruction was performed due to advanced incus erosion. Pre- and postoperative bone conduction (BC-PTA) and air conduction (AC-PTA) pure tone averages (0.5, 1, 2, 3 kHz) including high tone bone conduction (1, 2, 3 kHz), air-bone gap (ABG), and speech discrimination scores (SDS) were measured. Short-term (3 weeks) and medium-term (median, 12 months) hearing outcomes were measured.
Among 19 ears undergoing revision stapedectomy managed with TORP reconstruction, the average number of previous revision attempts was 1.2 (SD, 2; range, 1-6). The preoperative BC-PTA was 32.1 dB preoperatively while the preoperative AC-PTA was 65.3 dB. The mean postoperative ABG significantly decreased to 16.6 dB (SD, 13.68; range, −2.5 to 46.3 dB,
Total ossicular reconstruction in the setting of previous revision stapedectomy with limited incudovestibular reconstructive options may lead to favorable hearing outcomes but carries an increased risk of sensorineural hearing loss.
Could preoperative air-bone gap magnitude act as a predictor of postoperative outcome in patients undergoing stapedectomy for otosclerosis? If this were to occur, is it frequency specific?
Retrospective case series from January 2010 to December 2012 in a tertiary London teaching hospital. Patients: Evaluation of 302 stapedectomy procedures under the care of a single consultant. Intervention: Laser stapedectomy using Smart Nitinol stapes prosthesis. Retrospective analysis comparing preoperative and postoperative air-bone gap (ABG) in patients undergoing stapedectomy. Patients were stratified into subgroups according to their preoperative air-bone gap and this was compared with their postoperative result of air-bone closure. In addition, for each commonly tested frequency (0.5, 1, 2, 3, 4 kHz) the preoperative and postoperative air-bone gap were analyzed in order to ascertain whether the preoperative ABG could act as a predictor. Having not passed normality testing, Wilcoxon matched paired signed rank test and Spearman’s rank coefficient were used for analysis.
Throughout the statistical analysis, preoperative ABG correlated most strongly with net difference in postoperative ABG (
In performing stapedectomy for otosclerosis, our series suggested the preoperative ABG may have a role in preoperative patient counseling and consent, but is unable to predict success in stapedectomy surgery.
Investigate the therapeutic efficacy of intratympanic dexamethasone after high-dose systemic corticosteroids in patients with idiopathic sudden sensorineural hearing loss (ISSNHL).
Prospective clinical trial at a university hospital. A total of 104 eligible patients with ISSNHL were treated consecutively. Patients in the severe group (>70 dB) were treated with intravenous high-dose prednisolone (500 mg per day, 5 days), whereas the rest were treated with oral deflazacort (1 mg per kg per day, 10 days). Failures after 5 days of systemic treatment received an additional 3 intratympanic dexamethasone injections.
The differences between pretreatment and posttreatment pure-tone audiometry averages (PTAs). Complete recovery was defined as PTA better than 25 dBs. Successful treatment was defined as a greater than 10 dB improvement in PTA. Results: Complete hearing recovery was achieved in 38 cases (36.53%), and significant hearing recovery in 86 cases (82.69%). After intravenous treatment of severe cases (initial PTA 83.15 dB), a median improvement of 13.61 dB was achieved; rescue intratympanic treatment obtained 18.49 dB of further improvement (final PTA 53.05 dB). Those less severe cases (initial PTA 68.38 dB) had a median improvement of 3.39 dB after oral treatment, and 9.00 dB after rescue (final PTA 56.00 dB). High-dose treatment in severe cases showed a significant improvement compared with the less severe group (
High-dose intravenous corticosteroid treatment obtained significant hearing improvement in severe ISSNHL. The addition of intratympanic steroids to the conventional systemic steroid therapy may provide a safe and potentially effective therapeutic option.
Elucidate the incidence of cisplatin-induced ototoxicity in patients treated for head and neck cancer.
This was an institutional review board approved retrospective study of patients treated with cisplatin for cancer at a tertiary referral hospital. The charts of patients of any age that had undergone cisplatin therapy from 1995 to the present were reviewed. We then narrowed this group down to those who had a diagnosis of cancer of the head and neck (hypopharyngeal, laryngeal, nasopharyngeal, oropharyngeal, scalp/face skin cancer, temporal, thyroid) and had pre- and posttreatment audiologic testing.
There were 1565 patients that had undergone therapy with cisplatin from 1995 to 2014. Of those, 203 patients had pre- and posttreament audiologic testing. Twenty patients had diagnosis of cancer involving the head and neck. The cochlear radiation doses were also collected from these patients. Preliminary results demonstrate that patients with head and neck cancer that were treated with cisplatin and had a sizable cochlear radiation dose had significantly more permanent hearing loss following treatment.
The incidence of cisplatin induced ototoxicity was significantly more prevalent in head and neck cancer patients. These patients should be thoroughly screened and protective precautions should be taken to limit ototoxicity in this population.
Herpes simplex type 1 (HSV1) reactivation in sensory neurons may underlie a number of idiopathic head and neck syndromes, including Bell’s palsy and delayed facial palsy following traumatic injury. In this study we first measured whether modeled surgical nerve injury (hypoxia and heat) reactivated HSV1 in neurons harvested from different ganglia (geniculate, vestibular, trigeminal, and sympathetic). We also measured the phosphorylation status of mTOR pathway proteins in conditions that either did or did not cause HSV1 reactivation.
Basic/translation science study of cultured neurons latently infected with HSV1. Primary neuronal cultures were either kept under hypoxic conditions or heated to 43°C for 2 hours to simulate intraoperative neuronal injury. Outcome measures included HSV1 reactivation measured by expression of green fluorescent protein under HSV1 promoter and HSV1 viral titers. Other outcome measures included measurement of phosphorylation of mTOR1, S6, and S6kinase by western blot and immunofluorescent microscopy.
All latently infected neurons demonstrated HSV1 reactivation following hypoxia. Trigeminal, vestibular, and geniculate neurons demonstrated brisk HSV1 reactivation after heat treatment, but sympathetic neurons did not. All conditions leading to HSV1 reactivation significantly affected phosphorylation status of mTOR pathway proteins.
Conditions which reactivate latent HSV1 lead to changes in phosphorylation of mTOR pathway proteins. Conditions that do not lead to HSV1 reactivation do not affect the mTOR pathway.
Otolaryngology trainees in the United King-dom undergo regular procedure-based assessments (PBAs) throughout training, however, these are rarely used to monitor progress or measure competence. The assessment tool is procedure specific and produced by the Joint Committee of Surgical Training. It consists of 6 domains: consent, planning, preparation, exposure/closure, operative technique, and postoperative care. The aim of the study was to validate PBA in assessing otolaryngology trainees and to identify the level and pace at which trainees show competence in syllabus otological procedures.
This is a longitudinal study from October 2008 to October 2013. We analyzed all PBAs submitted by North-Thames London otolaryngology trainees, including junior or core trainees (CT) and senior specialty trainees (ST). We calculated and used the overall score (oS) mean and standard deviations to draw procedure-specific learning curves for common otological operations.
A total of 3306 PBAs from 46 trainees were analyzed, 621 were otological. PBA was highly reliable showing internal consistency (Cronbach’s Alpha: 0.921) and discriminated between different grades (CT and ST, Mann-Whitney-
PBA is valid for assessing ENT trainees. Procedure-specific competency curves can be drawn to set milestones and deliver targeted training. They can help understand the pace and level at which trainees master individual otological procedures replacing arbitrary numbers currently in use.
Review the long-term outcomes of cross-hatching Eustachian tuboplasty (ChEt) in patients with chronic obstructive Eustachian tube dysfunction (COETD), as well assess the clinical factors associated with surgical success.
Case series with chart review in a tertiary health care institution. This is a retrospective review by the senior author of all cases of patients who had nonrevision ChEt for COETD. Follow-up period was 5 years. The curvature of the posterior cushion was modified using an argon laser to alter the spring of the cartilage, alleviating the obstructed valve’s aperture. Several clinical factors were reviewed in relation to the successful opening of Eustachian tube valve.
One hundred twenty patients, 72 males/48 females, average age 42.4 ± 2 years old, met inclusion criteria to the study. COETD patients/obstructive causes were: Posterior cushion hypertrophy, 68 (56.6%); tensor veli and levator veli palatini muscles hypertrophy, 15 (12.5%); and remarkable mucosal hypertrophic disease, 37 (30.8%). Total of ET tubes was 198. Bilateral 198 (72.2%), 55 unilateral (27.7) ET valve was seen more open postoperatively on simple endoscopy (SE) and slow motion video analysis (SMVEA). There were no complications. Mean pure tone average improved by 20 dB postoperatively;
A high rate of improvement (96%) was found. Therefore, ChEt is a promising technique for the treatment of COETD.
(1) Compare the lateralization value of video head impulse test (vHIT) with that of bithermal caloric test. (2) Analyze the influence of covert saccade on VOR gain and unilateral weakness (UW) of caloric test.
Retrospective study from May 2012 through December 2013 in a tertiary referral center. There were 99 dizzy patients with peripheral vestibulopathy and 16 healthy volunteers. Caloric test parameters (UW and sum of warm and cold slow phase velocity [SPV] of each ear) were compared with VOR gain on vHIT. Cutoff point of vHIT was calculated using the receiver operating characteristic curve.
(1) Correlation between UW/Sum of SPV and the gain of vHIT was statistically significant and correlation coefficient was 0.655 (
Gain on vHIT was well correlated with UW on caloric test. However, both tests seem to be necessary since substantial proportion of patients showed conflicting results, which resulted from testing VOR of 2 extreme frequencies.
Previous studies have demonstrated that ongoing dizziness is a powerful predictor of reduced quality of life for patients with vestibular schwannoma (VS). The purpose of the current study is: (1) to characterize long-term dizziness following observation, microsurgery, and stereotactic radiosurgery (SRS) for small to medium sized VS using a validated self-assessment inventory and (2) to identify clinical variables associated with long-term dizziness handicap.
All patients with sporadic <3 cm VS who underwent primary microsurgery, SRS, or observation between 1998 and 2008 were identified. Subjects were surveyed via postal questionnaire using the Dizziness Handicap Inventory (DHI) and a VS symptom questionnaire.
A total of 642 respondents (mean age 56.2 years, 56.9% female) were analyzed and the average time interval between treatment and survey was 7.7 years. Female sex, older age, preexisting diagnosis of migraine, and symptoms of severe dizziness predating treatment were highly statistically significantly associated with a worse DHI score (
These data suggest that migraine may play a major role in long-term dizziness in patients with VS. Factors including history of dizziness predating treatment and preexisting diagnosis of migraine most significantly influence dizziness handicap among subjects with VS, while management strategy is not associated with long-term DHI outcome.
(1) Analyze the longitudinal hearing outcomes in children with evidence of dilated endolymphatic duct (ED) or endolymphatic sac (ES) on high resolution magnetic resonance imaging (HRMRI). (2) Correlate severity of hearing loss with ED/ES size and fluid-attenuated inversion recovery (FLAIR) signal.
This retrospective chart review examined medical records from 2000 to 2013 at a tertiary pediatric referral center to identify patients with evidence of enlarged ED and/or ES by HRMRI. Longitudinal audiometric data (pure tone averages [PTA]) was analyzed using chi-squared and simple linear regression analysis. Significance was set at
Seventy-four patients were identified with an enlarged ED or ES in at least one ear (normal ears used as controls). Audiometric data were available for 106 ears. In our patient population, increasing ED (linear regression,
Contrary to our current understanding, our data does not support a progressive nature for the hearing loss associated with enlargement of the ED and/or ES. It also introduces increased FLAIR signal as an additional predictor of poorer hearing outcomes.
Present the results of a 5-year longitudinal study in an adult population undergoing cholesteatoma surgery using a canal-wall-down (CWD) approach with obliteration.
Prospective longitudinal study from 1999 to 2013 in a district general hospital. Subjects studied: Adults (≥16 years) with cholesteatoma (256 ears). Interventions: Surgery for cholesteatoma. (1) Residual, recurrence, and recidivist cholesteatoma rates at 5 years postsurgery; (2) postoperative hearing; (3) postoperative waterproofing of the ear; (4) number of subsequent ear surgeries required. Independent variables: Age and sex.
The follow-up rate at 5 years was 81.5% (n = 195). Using Kaplan-Meier analysis, the residual cholesteatoma rates at 5 years postsurgery was 2.1% at a rate of 6.5 per 1000 years of adult follow-up (95% confidence interval [CI]: 2.4-17.3), representing 4 cases of residual cholesteatoma and no recurrences. The otorrhea rate was 5.6% at 12 months and the rate of definitive waterproofing was 89.8% at 12 months. There was a reoperation rate of only 6.7% at 5 years which included second stage ossiculoplasty. Regarding hearing, 62.2% preserved their hearing (change between −10 to = 10 dB), 36.5% had hearing gain (>10 dB), and 16.9% had hearing reduction at 12 months postoperation. Forty-eight percent (48%) achieved a postoperative air-bone gap of ≤20 dB.
Use of a CWD approach with obliteration of the mastoid cavity to surgically treat cholesteatoma results in a low recurrence rate and high rate of a trouble-free ear in the long term.
(1) Treat adhesive tympanic membrane (TM) retractions in children by lysis of middle ear adhesions during insertion of tympanostomy tubes (TT). (2) Analyze the ability to improve conductive hearing loss and to prevent progression of retraction pockets, incus erosion, and avoid future tympanoplasty.
A retrospective review from 2005 to 2013 was performed in 22 ears of 18 patients who were candidates for cartilage tympanoplasty to correct a progressive posterior-superior retraction pocket, with or without incus erosion. Lysis of middle ear adhesions using angled picks was performed through the myringotomy before insertion of a TT. The hypothesis was that the released redundant TM, wrapped around the barrel of the TT to maintain it under tension, could allow regeneration of a healthy tympanic membrane in children.
TM retractions were elevated and adhesions lysed in 22 ears. Mean age was 11.3 years (range, 4-22 years). Follow-up ranged from 3 to 72 months (mean, 23.2 months). Preoperatively, there were 15 Sade grade III and 7 grade IV atelectatic TMs. Postoperatively, there were 14 without retraction, 6 grade I, 1 grade III, and 1 grade IV TMs. Grade I and nonretracted TMs healed without dimers. Mean AB gap improved from 19.94 to 3.88 dB. Two ears required a revision procedure and a third ear developed a cholesteatoma.
Lysis of middle ear adhesions through a myringotomy at the time of TT insertion allows for healing of the tympanic membrane, improved hearing, and can be effective in preventing progression of atelectasis and incus erosion in children.
Determine the prevalence of middle cranial fossa (MCF) dehiscence on computed tomography (CT) scans and establish its increase with age.
All high-resolution temporal bone CT scans completed at a tertiary care center from 2011 to 2013, ordered by 1 otologist for any reason, were reviewed. Scans showing soft tissue, fluid, trauma, or previous operations were excluded. A total of 183 patients (296 ears) were reviewed blinded for age. The MCF floor was divided into 7 regions and systematically inspected. Ages of the patients were subsequently extracted from the medical record.
Logistic regression analysis confirmed increasing MCF dehiscence with age (
The incidence of MCF dehiscence increases with age. Over all ages, approximately 32% of ears show dehiscence. Over 60 years, approximately 55% show dehiscence. The increase of dehiscence with age is statistically significant. The most common sites along the MCF floor are in the epitympanum over the malleus head and additus ad antrum.
Determine the effect of sinonasal polyposis on middle ear (ME) and Eustachian tube (ET) function.
In a case-control survey, 90 cases in 3 groups including 42 advanced stage sinonasal polyposis patients, 24 patients with chief complaint of nasal obstruction in the absence of polyposis, and 24 healthy cases (not suffering from nasal obstruction or allergic rhinitis) were studied. Subjective ear- and nose-related complaints, tympanic membrane condition and movement during the Valsalva and Toynbee maneuvers, type of nasal secretions, polyposis staging both clinically (Lund Kennedy) and by imaging (Lund McKay), audiometric evaluation, and ET function tests were recorded.
Subjective hearing loss (
It seems that sinonasal polyposis may change middle ear function to some extent, but the changes are related to the inflammation (allergic or infectious) associated with polyposis, rather than the nasal airway obstruction per se.
(1) Assess the feasibility of endoscopic-assisted myringotomy and ventilation tube insertion in patients affected by chronic otitis media with effusion (COME). (2) Describe advantages and disadvantages of the endoscopic technique. (3) Compare the outcomes of the endoscopic-assisted approach with those obtained with the traditional microscopic technique.
The study was conducted from May 2010 to September 2013 at the ENT University Unit of the A. Fiorini Hospital, Sapienza University of Rome. A total of 24 patients (average age 46 ± 4.5 years; 9 males, 15 females) affected by unilateral or bilateral COME (27 ears, 12 right, 15 left) were enrolled in this prospective controlled trial. The diagnoses were confirmed by otoendoscopic examination, tympanometric and pure-tone audiometric measurements. Patients were randomly divided in 2 groups. Group A patients underwent myringotomy and ventilation tube insertion under endoscopic viewing, whereas in Group B the same procedure was performed using a surgical microscope. All cases were evaluated 1 week after surgery and then monthly until tube extrusion. Complications and tube extrusion times were recorded during follow-up. Audiometric measurements were carried out 2 months after tube extrusion.
The outcomes of surgery, assessed with endoscopy and audiometric measurements, were similar in the 2 groups. There were no significant differences in mean operative times, tube extrusion times, or complication rates (
The endoscopic technique seems to be a viable alternative to the traditional microscopic approach for myringotomy and ventilation tube positioning in patients affected by COME in the era of endoscopic ear surgery.
(1) Describe the benefits of the minimally invasive Punch Method without soft tissue reduction (PM) for the placement of percutaneous osteointegrated auditory implants. (2) Compare and contrast techniques and outcomes from PM with the Linear Method with soft tissue reduction (LM).
A retrospective chart review was conducted of all patients who received a percutaneous bone-anchored auditory implant from 2009 to 2013 at a tertiary otology practice by a single surgeon. LM was used until 2011 when a switch was made for all patients to PM. Preoperative variables recorded included age, sex, body mass index (BMI), smoking status, indication, and device selected. Outcomes measures included surgical time, skin reaction grading by Holgers score at 1 week and at most recent follow-up, and any other complications. Two-sample
Fifty-one patients (34 LM, 17 PM) were identified with an average follow-up of 16.9 months (22.3 LM, 5.8 PM). Average surgical time was found to be significantly shorter for the PM group (10.2 minutes vs 48.8 minutes,
The Punch Method offers several potential surgical and cosmetic advantages over the Linear Method, without compromising skin-reactivity outcomes. This study supports a growing trend towards minimally invasive percutaneous auditory implant surgery.
Characterize radiologic growth and clinical disease progression in a cohort of observed, previously untreated, jugular paraganglioma tumors (JPT).
Retrospective review evaluating all patients with primary JPTs that were observed with serial clinical examination and imaging between 1993 and 2013. Primary outcome measures included radiographic growth and progression of cranial neuropathy.
A total of 16 patients (75% female, median age 65.2 years) met inclusion criteria. One JPT was stage I, 7 stage II, 7 stage III, and 1 stage IV. Primary indications for observation included advanced age, minimal symptoms, contralateral paraganglioma(s), and patient preference. The most common presenting symptoms were hearing loss and pulsatile tinnitus; 6 patients were found to have lower cranial neuropathy at time of diagnosis (2 CN 9, 6 CN 10, 2 CN 11, 1 CN 12). At a mean clinical follow-up of 67 months, 6 patients endured progressive cranial nerve deficits and 4 tumors demonstrated unequivocal growth; the average rate of tumor growth was 1.2 mm/year. Six patients underwent vocal cord medialization procedures for dysphonia. Notably, no patients required feeding tube placement or tracheostomy and there were no deaths attributable to tumor progression.
In the absence of brainstem compression or concern of malignancy, initial observation of JPTs should be considered. A significant number of tumors do not grow after time of diagnosis, and symptoms frequently remain stable for many years. Even with disease progression, most JPTs exhibit indolent growth with slowly progressive cranial neuropathy affording satisfactory physiologic compensation in most patients.
Anatomical distortions of the neural structures surrounding the foramen of Luschka (FL) characterize children with cochlear nerve deficiency (CND). Our goal was to investigate the anatomical features of the nervus intermedius (NI) and cranial nerve 7 (CN) VII in children with CND and verify if the NI can provide an additional landmark during auditory brainstem implantation (ABI) surgery, preventing intraoperative injuries of the nearby vessels and nerves.
Sixty-four CND children ranging in age from 8 months to 16 years (2.92 ± 1.54) were video-recorded during retrosigmoid surgery for fitting the ABI and retrospectively examined with particular reference to the number and variety of NI bundles, the associated malformations of CN VII, the relationship with CN VII, and the possibility that NI might represent a landmark for ABI insertion.
Absence of CNs VI, VII, and VIII was observed respectively in 3, 8, and all children. Eighteen children showed several abnormalities of CN VII in the cerebellopontine angle. The identification of CN VII and of the bundles comprising NI was possible anatomically in 46 children. In 12 the identification was obtained with the assistance of intraoperative monitoring. The number of bundles comprising the NI varied from 1 to 6. The NI and CN IX were useful landmarks for identifying the FL of the lateral recess.
NI provides an additional landmark during ABI microsurgery. Knowledge of NI anatomy and its topographical relationship with the neurovascular structures around the FL may prevent iatrogenic injuries and ABI electrical stimulation of the surrounding cranial nerves.
(1) Describe a validated measurement instrument to quantify tegmen thickness on computed tomography (CT) images. (2) Compare tegmen thickness in 3 groups: patients with spontaneous cerebrospinal fluid (CSF) leaks, obese controls, and nonobese controls.
Retrospective review from 2005 to present. Patients with a diagnosis of spontaneous CSF otorrhea and dedicated temporal bone CT scans were included. Matched obese (body mass index [BMI] >30) and nonobese (BMI <30) controls were selected from a pool of cochlear implant candidates. The tegmen was measured radiographically in all patients at pre-defined points. Independent, blinded measurements were made by 3 of the authors and compared for interrater validity.
Ninety-nine patients were measured: 39 in the CSF group (BMI 35.9), 29 in the obese group (BMI 34.6), and 31 in the nonobese group (BMI 24.2). The CSF group had a significantly thinner aggregate tegmen thickness (0.82 mm ± 0.19) compared with both obese controls (0.99 mm ± 0.18,
This is the first study to (1) quantify lateral skull base thickness and (2) significantly correlate obesity with lateral skull base attenuation. Obese spontaneous CSF leak patients may have even greater attenuation of their skull base than matched obese controls. This finding may further support theories that an additional process, such as BIH, may play an important pathophysiologic role in skull base thinning.
Develop a functional assay of zebrafish (Danio rerio) swimming behavior correlated with anatomic studies of hair cells along the lateral line as a platform for high-throughput drug development against hearing loss.
In vivo animal study at university animal care facilities. Five-day postfertilization (dpf) zebrafish were treated with 0 (control)-1000 µM concentrations of cisplatin. In darkness, swimming behavior was analyzed using infrared video systems housed within a novel, multilane, high throughput apparatus to calculate the rheotaxis index (RI). The RI, which represents the ability of fish to properly orient relative to water current, allowed direct comparison of various cisplatin doses to controls simultaneously. Hair cells of zebrafish exposed to cisplatin were also stained with Yo-Pro1 and imaged using confocal microscopy in order to correlate anatomic changes with changes in swimming behavior.
A dose-dependent relationship between cisplatin concentration and RI was found. 0 µM (control): RI 39.85%; 250 µM: RI 38.11%; 500 µM: RI 25.12%; 750 µM: RI 22.97%; 1000 µM: RI 17.84%. The decline in rheotaxis performance correlated directly with increasing dosage of cisplatin.
There are currently no Food and Drug Administration–approved pharmacological treatments for hearing loss. Using a validated behavioral assay to test ototoxic dose of cisplatin against varying concentrations of potentially otoprotective/otoregenerative compounds establishes a first-ever, high-throughput biologic platform for drug development against hearing loss.
Congenital sensorineural hearing loss (SNHL) is relatively common, occurring in 2 to 4 per 1000 infants, with genetic etiologies accounting for nearly 67% of cases. The clinical presentation of patients with syndromic and nonsyndromic SNHL is often indistinguishable. Establishing specific genetic causes is imperative for clinical management and genetic counseling. Recent advances in next-generation sequencing have allowed for facilitated multi-gene testing in genetically heterogeneous conditions such as SNHL. The present study evaluates the clinical utility of one such assay, OtoSeq, in genotyping pediatric patients with SNHL.
Demographic, audiometric, imaging, and genetic data were retrospectively collected from 70 patients with prelingual hearing loss who underwent clinical genetic testing of 23 well-studied SNHL genes via OtoSeq, our next generation sequencing platform. The frequencies of pathogenic and likely pathogenic mutations were calculated and audiogram data were reviewed.
Of 70 patients studied, 15 patients (21%) were found to have an identifiable genetic etiology for their hearing loss, and 8 patients were found to have a previously undiagnosed genetic syndrome. Seven patients were diagnosed with nonsyndromic hearing loss. A total of 27 patients with mutations had adequate audiogram data available, of which 16 had mild to moderate hearing loss (59.3%) and 11 had severe to profound hearing loss (40.7%). Several unique combinations of deafness causing mutations in different genes were identified, including CDH23 and MYO7A, both Usher pathway of genes.
This study demonstrates that OtoSeq is a valuable tool for determining genetic causes of SNHL in pediatric patients, which has direct implications for their clinical management.
(1) Compare the air-bone gap between patients with posterior epitympanic (attic) and posterior mesotympanic (tensa) cholesteatomas. (2) Correlate the air-bone gap and intraoperative ossicular chain findings.
Cross-sectional study. In total, 262 patients with attic and tensa cholesteatomas treated at a tertiary hospital were included. Audiometry was performed, and the pure tone average air-bone gap (PTA-ABG) was compared between the 2 groups. In addition, ossicles were classified as normal, eroded, or absent based on intraoperative evaluation. Data were compared using the Mann-Whitney and Chi-square tests, and statistical analysis was performed using SPSS.
Attic cholesteatoma was diagnosed in 51.1% of patients and tensa cholesteatoma in 48.9%. The mean patient age was 33 ± 18.7 years, and 52.3% were male patients. The PTA-ABG was higher in tensa cholesteatoma cases than in attic cholesteatoma (30.25 ± 12.82 dB and 26.73 ± 13.08 dB, respectively,
The PTA-ABG was higher in tensa cholesteatoma cases and correlated with a lower normal incus prevalence and a higher eroded incus prevalence compared to attic cholesteatoma cases.
(1) Identify nascent candidate proteins producing the molecular dysregulation responsible for increased bone matrix deposition in otosclerosis compared to healthy control ossicles. (2) Evaluate the potential for active viral protein presence in otosclerosis. (3) Assess the utility of relative protein abundance quantification in bone tissue.
Pooled bone homogenate protein samples from 50 human stapes collected from patients with otosclerosis between January 2012 and June 2013 were produced in a multistage bone isolation protocol. Control samples including ossicles acquired from nonotosclerotic patients and axial bone from fibula reconstruction procedures were prepared by identical protocols. All samples were subjected to concurrent isotope tagged relative abundance quantification (iTRAQ) proteome deep sequencing analysis.
iTRAQ analysis revealed multiple proteins with altered translation levels representing possible candidate proteins for the bony deposition involved in otosclerosis. Literature review and functional assessment of candidate proteins is undertaken.
Proteomic analysis of otosclerotic bone samples provides novel potential agents in the development of otic capsule overgrowth and hearing loss. Further evaluation of these proteins may provide additional understanding of the pathophysiology of otosclerosis and develop additional treatment modalities.
Evaluate the efficacy of combined anti-staphylococcal and anti-pseudomonal preoperative antibiotics for preventing surgical site infections following tympanoplasty and mastoidectomy (TM) with contaminated cholesteatoma.
Study Design: Retrospective chart review Method: Medical records of patients who underwent TM for cholesteatoma were reviewed. Only cases considered to have contaminated or dirty/infected surgical fields were included. Patients were excluded if there was preexisting infection or intraoperative finding requiring systemic antibiotic therapy. The primary outcome measure was postoperative perichondritis, pinna abscess, peri-otic cellulitis, and peri-otic abscess requiring systemic antibiotics or surgical intervention.
The charts of 362 patients who underwent TM were reviewed. 195 met inclusion criteria. Preoperative antibiotics included clindamycin and ceftazidime or gentamicin. Patients treated with no perioperative antibiotics had an infection rate of 11% and those treated with perioperative antibiotics had a rate of 1% (
The use of preoperative antibiotics to cover staphylococcal and pseudomonal species prevented surgical site infections as compared to no perioperative antibiotics.
(1) Develop a multidimensional metric for assessing quality of life (QoL) in patients with NF2. (2) Compare NF2 results with reference values for the general population and patients with head and neck or brain cancer.
Structured interviews with NF2 providers and patients identified relevant domains. Items in these domains were extracted from validated EORTC modules, combined with items unique to NF2 and pre-tested on NF2 providers and patients (N = 118). The questionnaire included 61 items assessing overall QoL and 10 additional domains including hearing, balance, facial function, vision, oral intake, future uncertainty, psychosocial, cognition, sexual activity, pain and vocal communication. Responses were compared to reference values for the general population and head and neck cancer and brain cancer patients.
QoL in NF2 patients was lower than that of the general population (
Psychosocial stress and pain significantly impact QoL in NF2 indicating that mental health, pain management, and financial counseling could have an important impact on QoL in this population.
Auditory brainstem implants (ABIs) have been implanted in 64 children with no permanent major complications. We detail the protocol for ABI patient selection, ABI surgery and intra-operative monitoring, and device fitting and rehabilitation with children.
Sixty-four children received the ABI between 2000 and 2013. The follow-up ranged from 6 months to 8 years. A protocol is presented for acoustic and electrophysiological assessment of ABI candidacy. A retrosigmoid-transmeatal approach was used in the Neurofibromatosis type 2 (NF2) and a retrosigmoid approach in the nontumor children. Tests for assessing auditory and cognitive development and rehabilitation are recommended.
All children, except NF2 subjects, scored 0 before ABI implantation on all tests, even the 31 children previously fitted with a cochlear implant. Perceptual outcomes showed statistically significant improvements over time. At the last follow-up no significant postoperative complications were observed.
ABIs have been shown to be beneficial for children who cannot use a cochlear implant. However, implanting an ABI in a child requires special care and expertise and should only be undertaken by an experienced pediatric implant team. This paper presents a comprehensive protocol for application of ABIs in children.
(1) Analyze the recent trends in radiosurgery for vestibular schwannomas (VS). (2) Determine the number of VS treated with radiosurgery since 1990 in the United States.
Large databases were obtained by contacting the manufacturers of the 2 main radiosurgical machines used to treat VS in the United States. Analysis of de-identified data from Leksell Gamma Knife reporting was carried out to investigate the treatment trends for VS. The main variable investigated was the number of VS treated by radiosurgery in the United States. Extrapolations were made to the available data to estimate the trends of radiosurgical treatment.
The number of VS treated by radiosurgery has been increasing. In the US, radiosurgery for treatment of VS was approximately 150 to 200 per year from 1991 to 1993. However, VS cases treated by radiosurgery were approximately 1520 and 1490 in 2011 and 2012, respectively. This indicates an approximate average annual rate of increase of about 4.7% (SD: 8.6%). Currently, treatment of VS accounts for 8.4% of all head and neck radiosurgical procedures in the United States. Since 1991, the approximate number of patients undergoing radiosurgery for VS is 16,000 in the United States and 70,000 worldwide.
The current study shows a possible changing trend in the management of VS. Our findings support the conclusion of other studies that suggest a growing number of patients are opting to receive radiosurgical treatment. Additionally, the data highlights the growing population of VS treated with radiosurgery.
(1) Evaluate the use of subtotal resection as the primary treatment modality for large jugular paragangliomas in patients with intact lower cranial nerves. (2) Evaluate functional outcomes and tumor control following subtotal resection. (3) Identify the utility of salvage radiotherapy for residual progressive disease.
Retrospective series from a tertiary academic referral center evaluating patients who presented with advanced (Glasscock-Jackson grade 3 to 4) jugular paragangliomas (JP) and normal lower cranial nerve function. Primary outcome measures included extent of resection, long-term tumor control, need for additional treatment, and postoperative lower cranial nerve function.
Fourteen patients seen between 1999 and 2013 (mean age 48.6 years; range, 26-70) met inclusion criteria. The average maximum preoperative tumor dimension was 3.1 cm. The mean postoperative residual tumor volume was 29.3% (range, 3.5%-58.4%). When the residual tumor volume was less than 20% of the preoperative volume, no tumor growth occurred through an average of 35.4 months of follow-up (
Subtotal resection of JP with preservation of the lower cranial nerves is a viable management strategy. If >80% of the preoperative tumor volume is resected, the residual tumor is less likely to grow. Radiotherapy offers effective treatment for recurrent tumor following subtotal resection.
Autografting, the gold-standard method for facial nerve repair with tissue loss, in association with high quality scaffolds and cell implants, has disclosed distinct experimental outcomes. The aim of the study was to evaluate the functional and histological effects of bone marrow stem cells (BMSC) combined with polyglycolic acid tube (PGAt) in autografted rat facial nerves.
After neurotmesis of the mandibular branch of the rat facial nerve, surgical repair consisted of nerve autografting (groups A-E), contained in PGAt (groups B-E), filled with basement membrane matrix (groups C-E), with undifferentiated BMSC (group D) or Schwann-like cells that had differentiated from BMSC (group E). Axon morphometrics and an objective compound muscle action potentials (CMAP) analysis were conducted. Immunofluorescence assays were carried out with Schwann cell marker S100 and anti-B-galactosidase to label exogenous cells.
Six weeks after surgery, animals from either cell-containing group had mean CMAP amplitudes significantly higher than control groups. Differently from other groups, facial nerves with Schwann-like cells implants had mean axonal densities within reference values. This same group had the highest mean axonal diameter in distal segments. We observed expression of the reporter gene LacZ in nerve cells in the graft and distally from it in groups D and E. Group E cells had LacZ coexpressed with S100.
Regeneration of the facial nerve was improved by BMSC within PGAt in rats, yet Schwann-like cells were associated with superior effects. Accordingly, groups D and E had BMSC integrated in neural tissue with maintenance of former cell phenotype for 6 weeks.
(1) Compare noncontrast steady-state free precession (SSFP, also called FIESTA, CISS, and bFFE) magnetic-resonance imaging (MRI) to contrast-enhanced full sequence MRI for initial evaluation of retrocochlear pathology. (2) Assess the sensitivity and specificity of SSFP alone versus complete contrast-enhanced MRI as the gold standard.
Retrospective review of a tertiary care center radiology imaging database from 2006 to present was performed. Based on statistical power analysis, 50 studies with identified vestibular schwannomas and 53 studies with normal internal auditory canal (IAC) findings were included. Four expert reviewers performed blinded, randomized evaluation of non-contrast SSFP sequence and contrast-enhanced MRI studies to evaluate for retrocochlear pathology. MRI reports from the original studies were used as the gold standard. Using XLSTAT™ statistical software, data were analyzed using a 2-sided z-test of one proportion for each reviewer’s sensitivity and specificity against a 95% standard. Inter-reader reliability was determined using kappa analysis.
Four reviewers, including 2 neuroradiologists, one neurotologist, and one neurosurgeon had 100% specificity. Average sensitivity was 96% (range, 94-100%). There was no statistically significant difference when each sensitivity and specificity was compared against a 95% standard or in results between reviewers. Tumors eccentric in the IAC or with significant artifact were more likely to not be identified.
Noncontrast SSFP sequence MRI may be an effective initial study to perform for evaluation of vestibular schwannomas. Given its shorter duration (5 minutes versus 25 minutes) as well as the noncontrast method, clear advantages exist for this method.
(1) Investigate the results of cochlear implant receiver-stimulator (RS) placement using the tight postauricular subperiosteal pocket technique. (2) Compare the efficiency of solely using a tight subperiosteal pocket compared to the conventional bone-recess technique.
Retrospective series from a tertiary academic referral center. All primary and revision cochlear implant patients in whom the RS was placed into a tight subperiosteal pocket without additional fixation were included. Primary outcome measures included RS migration, prevalence of flap complications requiring revision surgery, and time difference comparing the conventional bony well and trough technique to use of a tight subperiosteal pocket.
Two hundred consecutive cochlear implants (average age 46.9 years) were analyzed. At a mean follow-up of 12.8 months, only 1 patient experienced device migration; however, none have required revision to date for complications related to RS placement. One patient experienced a hematoma that was managed with observation, and no other soft-tissue flap complications occurred. The subperiosteal pocket technique resulted in a 20% reduction in total operative time compared to conventional RS placement methods (
The tight subperiosteal pocket is a safe, durable, and time saving technique for RS placement during cochlear implantation. Notably, the prevalence of device migration was exceedingly low, and none have required revision surgery for device drift or flap complications to date.
Compare audiologic outcomes of total ossicular replacement prosthesis (TORP) ossiculoplasty performed with and without the placement of a stapes footplate prosthesis (FPP).
A retrospective chart review was performed to identify adult patients undergoing TORP ossiculoplasty by the same surgeon at a tertiary care center between 1998 and 2012. Indications for surgery included cholesteatoma, atelectasis/perforation, chronic otitis media, and glomus tumor. Patients with a history of stapes surgery on the ear of interest were excluded from the study.
A lower rate of prosthesis displacement and statistically better audiologic outcomes were seen in FPP patients. The pure-tone average air-bone gap (PTA-ABG) was closed to <20 dB in 69.8% (37/53) of patients in the study arm and 44.4% (48/108) of patients in the control arm (
Use of the titanium stapes FPP during TORP ossiculoplasty was associated with a statistically significant advantage in short-term PTA-ABG closure and a higher rate of successful rehabilitation of conductive hearing loss in this study. A lower rate of prosthesis displacement was seen in the FPP group, but further studies and longer follow-up periods are needed to validate this observation.
Tinnitus secondary to middle ear myoclonus (MEM) is very rare but troublesome symptom. Recently, we published a paper about the clinical characteristics and the general therapeutic effects of this rare type of tinnitus in a large case series. Here in this study, we evaluated the therapeutic effects of middle ear tendon resection surgery on intractable tinnitus caused by MEM.
This study included 20 patients with intractable tinnitus diagnosed with MEM and treated eventually with surgical resection of middle ear tendons through January 2007 to December 2013. Clinical characteristics and therapeutic response to surgical therapy were thoroughly evaluated.
Patients had a mean age of 32.3 years (range, 16-60 years) and the male to female ratio was 10 to 10.The most frequent nature of their tinnitus was crackling sound. Impedance audiogram and otoendoscopic examination of the tympanic membrane were helpful in diagnosing MEM. Postoperatively, tinnitus decreased or even immediately disappeared in all cases of the study. Scores of tinnitus visual analog scale (VAS) and Tinnitus Handicap Inventory were significantly decreased. One of the patients showed delayed facial nerve palsy with complete recovery in 2 weeks. One patient showed the recurrence of symptom of MEM tinnitus within 1 year and was completely recovered by re-operation.
Sectioning of the middle ear tendons for middle ear myoclonic tinnitus seems to be safe and effective which can be considered as a promising treatment modality for intractable MEM tinnitus.
(1) Describe the safety profile of performing translabyrinthine tumor removal and bone-anchored hearing aid placement during the same surgical procedure. (2) Describe the overall patient satisfaction of those individuals who underwent the above procedure.
Retrospective review from a tertiary neurotologic referral center of 154 patients who underwent concurrent translabyrinthine tumor resection and bone-anchored hearing device placement between 2004 and 2012. Patient records were reviewed to identify postoperative complication rates and bone-anchored hearing device usage. A Fisher’s exact test was used to compare the qualitative variables and Student
One hundred twenty-one (78.6%) of 154 patients undergoing concurrent translabyrinthine tumor removal and bone-anchored hearing device placement had no device-related complications. The most common device-related complications were skin overgrowth (8.4%), acute infection (5.2%), and chronic infection (3.2%). The overall and specific complication rates did not statistically differ from published bone-anchored device complication rates (all
Patients undergoing concurrent translabyrinthine tumor removal and bone-anchored hearing device placement exhibit similar device-related complication profiles as patients undergoing standard device placement. Based on these outcomes and the high long-term usage rates, translabyrinthine intracranial surgery and bone-anchored hearing device insertion can be considered a useful and safe procedure.
This presentation describes a Phase II clinical trial that was conducted to assess transcranial magnetic stimulation (TMS) as a treatment for chronic tinnitus. (1) Interpret the results of this clinical trial. (2) Describe the issues that need to be addressed before TMS can be implemented clinically as a treatment for tinnitus.
This is a randomized, subject and clinician/observer blind, placebo-controlled parallel-group clinical trial of repetitive TMS (rTMS) for chronic tinnitus that was conducted from January 2011 to December 2014 at Portland VA Medical Center. 60 subjects (average age 61.2 years) who experienced chronic tinnitus for 1 year or longer were randomly assigned to receive either active rTMS treatment or placebo treatment to either the left or right side of the head. Subjects received 2000 pulses of 1 Hz rTMS therapy daily on 10 consecutive work days. The primary outcome measure is the Tinnitus Functional Index (TFI), a 25-item questionnaire that assesses tinnitus severity. Independent variables: Beck Depression Inventory score; State Anxiety Inventory score. Preliminary analysis: Change in TFI score from baseline at 6 post-treatment time points.
Fifteen of 30 subjects in the active rTMS group exhibited significant improvement in TFI score that persisted for 6 months posttreatment. Seven of 30 subjects in the placebo rTMS group exhibited significant improvement in TFI score.
While rTMS demonstrates potential as a treatment option for tinnitus patients, additional clinical trials should be conducted to confirm the efficacy of this method.
The primary goal of this systematic review was to test the null hypotheses: (1) aspirin has no impact on the prevalence of sensorineural hearing loss; and (2) any such impact is not dose-dependent.
Computerized searches of MEDLINE, PubMed, Cochrane, and EMBASE databases through January 2014 were performed with manual searches and inquiries to topic experts. A systematic review was performed according to an a priori standardized protocol. Data extraction was performed by 2 independent parties (an audiologist and an otolaryngologist) and focused on relevant audiological measurements, study designs, and potential confounders.
The 37 criterion-meeting studies included a combined total of 185,155 participants. Audiometric data consistently suggested aspirin had a deleterious, dose-dependent effect. The strongest data analysis arose from a randomized placebo-controlled trial, which demonstrated worse pure tone thresholds, speech discrimination scores, and hearing in background noise in the group receiving aspirin in 325 mg doses. Data from self-report of hearing symptoms suggests the potential for effect modification by sex. Paradoxically, level 1 evidence also demonstrates that aspirin has a protective effect on hearing when co-administered with gentamicin.
With the large-scale population use of aspirin for cardiovascular prophylaxis and other benefits, the potential risks to hearing health should be considered, particularly given that the effects may be reversible or improved with altered dosing. With the increasing prevalence of hearing loss in all age groups and segments of the population, attention to widespread exposures of risk may help preserve hearing-related health.
Enlarged vestibular aqueduct (EVA) is the most common inner ear malformation. While a strong correlative relationship between EVA and hearing loss exists, its association with vestibular dysfunction is less well established. In this study, we characterize the vestibular phenotype in patients with EVA.
This was a prospective, cross-sectional study of 106 patients with unilateral (n = 26) or bilateral (n = 80) EVA, defined as a midpoint diameter greater than 1.5 mm, who were referred or self-referred to participate in a study of the clinical and molecular analysis of EVA at the National Institutes of Health. We obtained a clinical history focused on vestibular dysfunction, and specifically asked about age of independent walking, history of vertigo, head tilt with vomiting, and clumsiness. Based on tolerance and availability, participants underwent videonystagmography (VNG), cervical vestibular evoked myogenic potentials (cVEMP), and rotary vestibular chair testing (RVT) to objectively assess their vestibular function.
Forty-five percent of patients with EVA reported vestibular symptoms. A total of 44% (28 out of 66) of those completing VNG testing had abnormal results, as defined by abnormalities in caloric, ocular motor, and positional testing. An increased number of vestibular symptoms is correlated with the presence of bilateral (rather than unilateral) EVA (
Vestibular dysfunction is common in patients with EVA. To our knowledge, this is one of the largest prospective EVA studies which specifically address the vestibular manifestations.
Evaluate the role of endoscopic approaches during exclusive or combined (microscopic and endoscopic) procedures to stapedial region, particularly in difficult cases or in anatomic abnormalities.
From 2009 to 2014, 56 endoscopic exclusive or combined (microscopic and endoscopic) approaches to the stapedial region were performed at the otolaryngology department, University Hospital of Modena. Operations performed were stapedoplasties or explorative tympanotomies for conductive hearing loss. Video, patient charts, and operative reports from surgeries were reviewed in February 2014. Cases in which stapedial abnormalities were identified were included and analyzed in the present study.
In 8 cases a malformed stapes was identified. Of those, 6 were eventually treated, while in 2 cases, after a diagnosis was made, a conservative attitude was chosen. Under endoscopic view, precise procedures under direct view were made possible, even in very delicate and hidden regions.
Whether chosen as a pure explorative tool, or as the main operatory visualization modality, endoscopy can guarantee very good visualization of the stapedial region, and may help in diagnosing and fixing altered stapedial conditions.
(1) Describe data on comprehensive vestibular testing in migraine-associated vertigo patients. (2) Delineate specific findings in vestibular testing that can assist in the diagnosis and treatment of migraine-associated vertigo.
A retrospective case review of individuals diagnosed with migraine-associated vertigo after evaluation by an otologist, a neurologist, and who had vestibular testing between January 1, 2010, and June 31, 2012, at a tertiary referral center. Videonystagmography (VNG), sinusoidal harmonic acceleration (SHA) testing, and cervical vestibular evoked myogenic potential (cVEMP) testing were analyzed.
Eighty-three patients met inclusion criteria; 63 had a diagnosis of primary migraine-associated vertigo. An additional 20 patients had a secondary diagnosis including Ménières disease, intracranial hypertension, and a history of cranial surgery (secondary migraine-associated vertigo). The average patient was 49 years old, with 82% being female. There was no statistically significant difference between the 2 groups. Overall, 30% of migraine-associated vertigo patients had abnormal caloric testing with a 60% average unilateral weakness. The unilateral weakness was to the right 77% of the time. When VNG, SHA, and cVEMP testing were combined, 24 patients (29%) had an identifiable vestibular weakness; 75% had a peripheral source and 25% had central vestibular findings. A total of 50% of patients with a peripheral weakness were fully compensated, 33% were partially compensated, and 17% were poorly compensated.
In patients with primary and secondary migraine-associated vertigo, approximately two-thirds of patients were found to have normal vestibular testing. When there was an identifiable vestibular weakness, 75% were peripheral with only 50% fully compensated.
(1) Describe the clinical presentation, management, and complications associated with button battery impaction in the aerodigestive tract in children. (2) Evaluate the long-term morbidity associated with button battery impaction.
This study is a retrospective medical record review involving 23 consecutive patients who presented to a tertiary care childrens hospital between January 1, 2000, and July 31, 2013, with button batteries impacted in the nasal cavity (n = 7), esophagus (n = 9), and stomach (n = 7). Battery type/size, duration of impaction, presenting symptoms, treatment, and outcomes were examined.
Average time of battery impaction was 40.6, 30.7, and 21.0 hours in the esophagus, nasal cavity, and stomach, respectively. 3V lithium batteries accounted for 84% of battery injuries and were responsible for all cases of esophageal impaction. Most common presenting symptoms were vomiting (30.4%), fever (26%), and cough (21%). Presenting signs and symptoms did not predict severity of injury or outcomes. Average length of hospitalization was greater for esophageal impactions (43.0 days) than for nasal or stomach impactions (2.0 days;
Button battery impactions in children present with nonspecific symptoms that may account for the delay in medical care. Clinicians must consider battery impaction in the upper aerodigestive tract as a surgical emergency that may lead to significant long-term morbidity.
(1) Review the reasons, timing, management, and costs for children presenting to the emergency department (ED) after tonsillectomy or adenotonsillectomy (T&A).
A standardized activity-based hospital accounting system was used to create an observational cohort of children from an academic pediatric otolaryngology practice who presented to the ED after T&A from 2011 to 2012. The reason for presentation, number of days after surgery, and facility costs for each visit were recorded.
The study cohort included 176 patients. Five of the patients had visits unrelated to the operation. Of the remaining patients, 21% presented for post-tonsillectomy hemorrhage, 54% for dehydration, 13% for poorly controlled pain, and 12% for other miscellaneous reasons. The mean postoperative day at the time of ED presentation was 3.7 ± 3.4 days. The mean hospital facility cost when the patient was discharged from the ED was $153 per visit. This increased to $1,634 per encounter when the patient was admitted or observed overnight, and the cost per return to the OR for bleeding was $1,392 per episode.
A relatively significant portion of children present to the ED after T&A for dehydration, poorly controlled pain, or hemorrhage. The costs from these visits are not insignificant. Developing strategies to reduce these visits may improve outcomes and reduce costs.
(1) Obtain caregiver reported outcomes including number of missed work days (caregivers) and school (child) after tonsillectomy or adenotonsillectomy (T&A). (2) Quantify the indirect costs associated with caring for a child after T&A.
A telephone survey was conducted of caregivers of children from a pediatric otolaryngology clinic who underwent T&A from October 2013 to January 2014. Caregivers were surveyed 2 to 5 weeks after surgery. Information obtained included number of postoperative days the child had symptoms, number of missed school and work days, and caregivers out of pockets costs for medical expenses, child care, and work absence.
Surveys were attempted with caregivers of 141 pediatric patients and 53 completed surveys were obtained, for a response rate of 37.6%. Mean patient age was 6.1 ± 3.9 years. Patient symptoms persisted for a mean of 10.8 ± 4.4 days after surgery. On average, patients returned to normal activity at 10.1 ± 4.8 days and normal diet at 11.3 ± 5.7 days. The average school absence was 10.0 ± 6.6 days. A total of 38 of 53 (71.7%) caregivers required time off work with a mean work absence of 4.9 ± 3.9 days. The mean income loss (for those missing work) per T&A was $626 ± 444. The combined income loss for the caregivers was $21,922.
Indirect costs of pediatric T&A are significant due to missed school and loss of income from employment absence. The caregiver reported outcomes and indirect costs measured in this survey could be used in future studies to compare the effectiveness of different tonsillectomy techniques or postoperative pain management protocols.
(1) Describe outcomes from and modifications to the hybrid, also known as the one-and-a-half stage, laryngotracheal reconstruction (LTR) technique. (2) Compare this technique to traditional single and double-stage LTR (ssLTR/dsLTR).
Retrospective review of patients under 18 years of age who underwent LTR by a single surgeon at a tertiary care otolaryngology specialty hospital from July 1, 2009, to December 31, 2013, was performed. Charts were assessed for age, sex, etiology of stenosis, type of reconstruction, comorbidities, length of stay, complications, and tracheostomy status.
Forty-four patients were identified, with 13 one-and-a-half stage LTRs, 27 ssLTRs, and 4 dsLTRs. Of the one-and-a-half stage LTRs, an operation-specific decannulation rate of 77% was noted, comparable with those for ssLTR and dsLTR. The one-and-a-half stage LTR technique offered a significantly shorter period of narcotic use when compared with ssLTR (16 vs 23 days,
The hybrid LTR technique is well-tolerated and useful in patients of all ages. Narcotics are able to be weaned more quickly because of the presence of a secure airway at all times via the existing tracheostomy. Use of a long stent prevents formation of granulation tissue that may be seen with a suprastomal stent. This technique should be considered in patients with high-grade stenosis with a pre-existing tracheostomy.
Compare advanced airway placement (1) success rate and (2) time taken between direct laryngoscopy, video-assisted laryngoscopy, and laryngeal mask airway (LMA) in a difficult infant airway simulator.
Prospective, randomized trial in an cademic, tertiary medical center. Twenty-two pediatric residents, interns, and medical students were tested between November 2013 and January 2014. Participants were provided a single training session by faculty from the subspecialties of pediatric otolaryngology, pediatric critical care medicine, and pediatric anesthesiology using a normal infant manikin. Subjects then performed all 3 of the aforementioned advanced airway modalities in a randomized order on a difficult airway model of Pierre-Robin sequence including features of micrognathia, glossoptosis, and cleft palate. Success was defined as a confirmed endotracheal intubation or correct LMA placement by the testing instructor in 120 seconds or less.
Direct laryngoscopy demonstrated significantly higher placement success rate (77.3%) than video-assisted laryngoscopy (36.4%,
Pediatric trainees demonstrated significantly higher success using direct laryngoscopy in a difficult airway model of Pierre-Robin. Video-assisted laryngoscopy users took significantly more time to establish a successful advanced airway. Given the potential life-saving implications of advanced airway adjuncts including video laryngoscopy and LMA placement, more extensive training on adjunctive airway management techniques may be useful for in this population.
Investigate the efficacy of preemptive montelukast, which is leukotreine receptor blocker for pediatric posttonsillectomy pain management. This is the first time montelucast has been used in posttonsillectomy pain control.
A total of 60 children, aged 5 to 15 years, American Society of Anesthesiologist (ASA) class I-II, scheduled for elective tonsillectomy were enrolled in this double-blinded and controlled study from April of 2013 until January of 2014. The patients were randomized into 2 groups: Montelukast group (Group M, n:30) and control group (Group C, n:30). Group M received 5 mg oral montelukast tablet and Group C received placebo at 24:00 pm the night before surgery. The posttonsillectomy pain was evaluated with Wong-Baker Face Scale during the 24 hours after surgery. Postoperative complications were recorded. The data were analyzed using the Student
There were statistically significant differences between Wong-Baker Face Scale scores of the Group C and Group M (
Preemptive montelukast usage is more effective than the control group in posttonsillectomy pain relief.
Study ethnic disparities in rates of complications in inpatient pediatric tonsillectomy patients.
Study Design: Retrospective cohort study. Setting: USA pediatric discharge samples from 2003, 2006, and 2009 calendar years. Method: This study examined inpatient admissions for pediatric tonsillectomy in 2003, 2006, and 2009 using the Kids’ Inpatient Database (KID), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality. Outcomes were analyzed for racial disparities. Pearson chi-squared was used to analyze categorical data and linear regression for continuous variables. Logistical regression and multivariate linear regression models were created to assess for confounding and to create odds ratios.
The estimated population of inpatient pediatric patients who underwent tonsillectomy was 82,222. Forty-two percent were female. The ethnic breakdown was: 52% white, 20% black, 19% Hispanic, 2% Asian, 6% other. The mean length of stay was 2.3 days and the complication rate was 18%. The postoperative bleed rate was 13% and 2% required a blood transfusion. Black children had longer hospital stays (3.0 days vs 2.1 days,
Ethnic disparities exist among pediatric inpatient tonsillectomy patients. Further research to understand the etiology of these differences is necessary.
(1) Describe the current benefits and risks associated with perioperative prophylactic myringotomy during cleft lip/palate surgery. (2) Recognize potential predictive factors associated with middle ear disease following cleft lip/palate surgery. (3) Incorporate ethnic differences into treatment algorithms regarding tympanostomy tubes.
A total of 241 children (129 Ecuadorian, 112 Chinese) underwent cleft lip/palate repair (2000-2009). Veau classification, age, history of ear infections, and cleft side were recorded. Average age was 2.4 years and 11.1 years for Ecuadorian and Chinese children, respectively. No patients underwent tympanostomy tube placement. Following surgical correction, serial otoacoustic emissions (OAE) testing, and tympanometry were performed, and a parental questionnaire was administered regarding behavioral hearing deficits and history of ear infections before and after surgery. Data were recorded and compared individually for the 2 populations and as a group to identify disease prevalence and correlative factors.
No association existed between Veau classification and deficits in tympanometry, OAE, or subjective hearing. Reported ear infections after surgery were fewer than before but were not significant (26% to 21%). Abnormal OAE testing was associated with abnormal tympanometry and subjective hearing deficits (
Severity of the cleft lip/palate is not a predictive factor of middle ear disease and hearing impairment when no tympanostomy tube is placed. Ideal pressure equalization tube protocols should incorporate ethnic differences.
Realize whether the adenoid size and severity of chronic nasal obstruction symptoms may decrease with intranasal mometasone furoate application in children affected with adenoidal hypertrophy.
Forty children with severe adenoidal hypertrophy (aged between 4-12 years) were recruited between August 2012 and April 2013 in a prospective randomized clinical trial. Primary nasal endoscopy showed more than 75% choanal obstruction in all patients. Subjects were randomly divided into 2 groups. The study group (n = 20) underwent mometasone nasal spray treatment (100 micrograms per nostril every 12 hours) for 4 weeks, and the control group (n = 20) received saline solution nasal spray as placebo in the same manner. Adenoid size and subjective symptoms were evaluated and compared between the 2 groups.
At the start of the experiment, there was no significant difference in the mean scores for any of the subjective symptoms (nasal obstruction, snoring, mouth breathing) between the 2 treatment groups. At the end of 4 weeks, statistically significant improvement was observed in total subjective symptom scores with mometasone treatment compared with placebo (
Treatment with mometasone furoate nasal spray causes a substantial improvement in nasal obstruction symptoms and reduction in size of adenoid in children with adenoidal hypertrophy and may obviate the need for surgery in these patients.
(1) Describe a presentation of first branchial cleft anomalies. (2) Compare outcomes of first branchial cleft to other branchial cleft anomalies with attention to otologic findings.
For this case-controlled study, databases at Seattle Childrens Hospital were queried by International Classification of Disease (ICD) and Current Procedural Terminology (CPT) codes for pediatric branchial cleft cases from 2004 to 2013. Inferential analysis was performed using unpaired
The query identified 104 subjects; 24 (23.1%) of whom had first branchial cleft anomalies, the remaining 80 (76.9%) had second or third branchial cleft anomalies. First branchial cleft anomalies were diagnosed at an older age, 2.65 years (SD = 3.3) versus 1.66 years (SD = 4),
Children with first branchial cleft anomalies present with a range of otologic manifestations that increase the risk of persistent disease and that may require specific treatment such as tympanoplasty.
American Academy of Otolaryngology—Head and Neck Surgery 2011 guidelines for pediatric tonsillectomies recommend routine administration of perioperative dexamethasone and against routine antibiotic administration. The purpose of this study is to review adherence to these 2 guidelines.
An observational cohort was reviewed of all children ages 1 to 18 years undergoing same-day-surgery adenotonsillectomy (T&A) at a multi-hospital network from 2007 to 2012. A standardized electronic data system was used to determine whether dexamethasone and/or antibiotics were given in the hospital. The rate of dexamethasone and antibiotic administration was compared in the years 2007 to 2011 (preguidelines) with the year 2012 (postguidelines).
The study cohort included 16,310 children undergoing T&A at 19 hospitals by 61 surgeons. A total of 91.3% of the patients from 2007 to 2011 (N = 13,557) received dexamethasone compared with 93.2% of the children in 2012 (N = 2,753). A total of 18.2% of the children from 2007 to 2011 received antibiotics compared with 14.7% in 2012 (
The majority of hospitals and surgeons administered perioperative dexamethasone before and after the guidelines were published. While the rate of antibiotic administration statistically decreased in 2012 compared to 2007-2011, only 2 surgeons appeared to have changed their practice. With the purpose of the guideline to limit the risks and side effects of perioperative antibiotics, interventions are needed to improve guideline adherence.
Evaluate change in true vocal fold length as function of age.
Prospective study at tertiary aerodigestive center between 2011 and 2013. A total of 205 patients (ages 1 month to 20 years), of which 87 (42.4%) were female and 118 (57.6%) male, were included. Lengths of total vocal fold (TVFL), membranous vocal fold (MVFL), and cartilaginous vocal fold (CVFL) were measured during direct laryngoscopy. Membranous-to-cartilaginous ratios (M/C) were calculated.
Mean MVFL under age 1 year for females was 4.4 ± 1.3 mm and for males 4.9 ± 1.8 mm. At age 17 years, mean MVFL was 12.3 ± 2.1 mm for females and 14.0 ± 1.4 mm for males. Mean TVFL, MVFL, and CVFL increased 0.7 mm, 0.5 mm, and 0.2 mm per year in linear fashion, respectively (linear regression,
This is the largest longitudinal pediatric study specifically examining vocal fold length as function of age. Each length of true vocal fold appears to linearly increase for both females and males. M/C ratio remained relatively constant unlike previously reported data, possibly due to in vivo versus cadaveric measurements. These findings suggest critical periods of development in females and males are not explainable by changes in vocal fold length alone, and other factors such as vocal fold layers (linear density) need further exploration.
Access to hearing health care is limited in many parts of the world. Specifically, many risk factors for hearing loss are present in the First Nations people of Canada’s North. No research has been done to assess this populations hearing in over 3 decades. The aims of the study were: (1) Determine the prevalence of hearing loss in children in Baffin Island. (2) Demonstrate the use of asynchronous tele-audiometry. (3) Conduct a cost-benefit analysis of iPad audiometry in the Canadian Arctic.
iPad audiometers were used to test hearing in 220 children ages 5-11 years in Iqaluit, Nunavut, during 1 week in January 2014. Air conduction pure tones were obtained from each ear at frequencies of 500, 1000, 2000, and 4000 Hz. Children with hearing loss greater than 25 dB in at least 1 frequency were considered to have failed the hearing test and will be further tested with standard sound booth audiometry.
Preliminary analysis reveals a hearing loss prevalence of 15.5%. These children then received standard testing by an audiologist using standard sound booth audiometry and the results analyzed. A cost-benefit analysis assessed the use of iPad audiometry in this remote location.
This is the first study in over 30 years assessing the hearing of children in this region, and the first telemedicine audiometry in Canada using iPads. This type of testing is valuable for providing hearing health care for high risk populations in rural and remote areas at an affordable cost.
(1) Determine incidence/grading of subglottic stenosis on endoscopic evaluation in recurrent croup. (2) Determine incidence of reflux on bronchoalveolar lavage (BAL) and esophageal biopsy (EBx) in pediatric population of recurrent croup.
A retrospective chart review was conducted of pediatric patients (age ≤ 18 years) who underwent endoscopic evaluation with a diagnosis of recurrent croup over a 10-year period (2002-2012). A total of 1825 charts were reviewed, of which 269 were identified for inclusion, with preliminary results completed for the first 80 patients. Endoscopic findings, BAL cytology results, and EBx pathology were collected. Subglottic stenosis (SGS) was graded on Myer-Cotton scale. Lipid-laden macrophages (LLM) on BAL were noted as none/small/moderate/large with evidence of reflux noted as moderate or large. Bx specimens were evaluated for evidence of reflux esophagitis.
Mean age at endoscopy was 56 ± 5 months. SGS was noted in 19 of 80 patients (24%) and all were grade I. Moderate-large LLM were noted on 0 out of 14 BAL in SGS group. Moderate-large LLM were noted on 5 out of 48 BAL (10%) in non-SGS group. Evidence of reflux was noted on 6 out of 19 (32%) EBx in SGS group. Evidence of reflux was noted on 5 out of 57 (9%) EBx in non-SGS group. There was no difference between the groups on preliminary data analysis (LLM
Recurrent croup is a risk factor for subglottic stenosis. Evidence of reflux may be noted on BAL or esophageal biopsy but this may not correlate with SGS in recurrent croup patients.
Arteriovenous malformations (AVMs) are congenital vascular malformations that result from a defect in vascular morphogenesis. These lesions are slow-growing, infiltrative, and destructive resulting in significant morbidity associated with cardiac overload and increased susceptibility to massive bleeding. Recent evidence suggests a role of matrix metalloproteinases (MMPs), a family of enzymes functioning in tissue remodeling via degradation of extracellular matrix proteins and cleaving of surface molecules, in the pathogenesis of AVM development and rupture. This study sought to explore the role of MMPs, particularly MMP-9, in AVM formation and progression.
Serum samples from patients with AVM, hemangioma, and pyogenic granuloma were collected and isolated at various stages of development. Relative quantities of MMP-2, MMP-9, and VEGF in each group were calculated and analyzed using sandwich-capture enzyme-linked immunosorbent assay.
MMP-2 concentrations were found to be decreased in AVM serum samples when compared with serum samples from the pyogenic granuloma controls (27.9 ± 5.97 vs 32.84 ± 2.20,
The results of this study provide support for a role of MMP-9 in AVM progression and recurrence. Specifically, an increase in MMP-9 appears to be associated with AVM formation and may play an important role in its pathogenesis.
Seven-valent pneumococcal conjugate vaccine (PCV7) has been proved to be very effective on preventing invasive pneumococcal disease (IPD) and pneumonia in children and having indirect effect on unvaccinated age groups. Previous studies also showed that PCV7 vaccination decreased the incidence of otitis media and tympanostomy tubes (TT) insertions in vaccinated children. However the indirect effect of PCV7 on TT insertions has seldom been mentioned. PCV7 was released in Taiwan in 2005. It is only for high risk group and in the private market. Partial vaccination makes Taiwan a perfect model to study the indirect effect. We tried to examine the indirect effect of PCV7 on TT insertions in a population based setting.
This retrospective study used the National Health Insurance databank for the period 2000 to 2009 in Taiwan. Every child under 18 years old who received TT in this 10-year period was identified and analyzed. The TT insertion rates in different age groups before and after the year 2005 were compared.
The TT insertion rate of children under 2 years old decreased significantly and increased in children 2 to 9 years after the year 2005. There is no obvious change in TT insertions for children older than 9 years old through the study period.
The PCV7 may reduce TT insertion rate for children under 2 years old in Taiwan. This effect may be the direct effect or both direct and indirect effect of the vaccine. There was no indirect effect of PCV7 on TT insertions in children older than 2 years old.
(1) Examine the frequency of partial glossectomy performed for the indication of macroglossia in the United States, assessing for any differences in rates of intervention across various demographics. (2) Identify potential morbidities associated with partial glossectomy in this population and determine how such factors may influence length of stay (LOS) and cost of admission following tongue reduction surgery.
Retrospective cross-sectional study using the 2006 and 2009 KidsTM Inpatient Databases (KID). During the 2-year study period, partial glossectomy was performed in 80 children under 5 years with macroglossia.
A disproportionately higher rate of intervention was seen in whites (
Partial glossectomy for macroglossia is typically performed prior to age 2 years in the United States. Syndromic comorbidities do not seem to contribute to increased LOS or cost of admission. White children and affluent children appear to be undergoing partial glossectomy at a higher rate than their peers.
The implications and anatomical basis of pediatric snoring (PS) remain largely unknown. The objectives of this study are to: (1) Objectively assess PS using home sleep test (HST) technology. (2) Attempt to correlate the objective components of PS to upper airway anatomy. (3) Objectively measure the effects of adenotonsillectomy (±turbinoplasty) on PS.
Pediatric patients with a chief complaint of snoring and probable obstructive sleep apnea underwent a HST (SNAP Diagnostics, USA) with a detailed acoustical analysis of snoring prior to adenotonsillectomy (±turbinoplasty). During surgery, detailed anatomical measurements were performed and correlated with snoring analysis results. After surgery, patients were offered another HST with snoring analysis. Data analysis was performed using descriptive statistics and statistical correlation with attention to the multiple comparisons paradox.
Twenty-two patients (45% male; mean age, 5.4 years; range, 2.4-8.4 years) completed the preoperative HST and intra-operative measurements. Unlike typical adult snoring, only the minority of PS was from palatal flutter (mean palatal component = 24%, median = 10%). The resistance occurrence percentage (ROP, % of breathing events with snoring noise) was associated with body mass index (BMI; Spearmans Rho = 0.55,
Pediatric snoring has different acoustical characteristics than adult snoring. Objective PS is associated with BMI, turbinate size, and palatal position/obstruction. Adenotonsillectomy (±turbinoplasty) significantly reduces objective PS.
Determine whether overlay tympanoplasty has equivalent outcome to underlay tympanoplasty in children.
A retrospective cohort study was performed. Data from primary tympanoplasties performed between 2005 and 2013 in children ages 2 to 13 years old by a single surgeon at a single pediatric tertiary care institution were reviewed. Outcome reviewed included anatomical success, hearing results and cholesteatoma.
A total of 104 cases were included; 21 overlay and 83 underlay tympanoplasties. Children having undergone an overlay tympanoplasty were more likely to have an anterior perforation (
In the current series, overlay pediatric tympanoplasty was associated with a higher rate of anatomical success, but worse hearing outcome and increased risk of cholesteatoma. Further, larger studies are needed to define which children benefit from the increased anatomical success rate of overlay tympanoplasty.
Analyze outcomes of tympanomastoidectomy for chronic otitis media in children at a tertiary care referral center with a high prevalence of patients with genetic syndromes, craniofacial anomalies, and medical comorbidities.
A retrospective review of tympanomastoidectomy performed for chronic otitis media at a single pediatric tertiary care hospital from 1995 through 2013 was performed. Factors evaluated included presence of immunodeficiency or craniofacial anomaly, change in air-bone gap and speech reception threshold, and need for additional otologic procedures.
Fifty-six tympanomastoidectomies on 47 patients were evaluated. A total of 25% of the children had a genetic syndrome and 17% had an immunodeficiency. Average age at surgery was 7.5 years with an average duration of follow-up of 2.7 years. Previous treatment included prolonged oral antibiotics (43), prolonged intravenous antibiotics (11), and middle ear irrigation and exchange of tympanostomy tube (7). Twenty-nine ears had undergone 2 or more tympanostomy tube insertion. A total of 28 (50%) ears continued to have some otorrhea postoperatively. Complete audiologic data were available for 23 patients. Improvement in air-bone gap was seen in 87% of cases, with an average improvement of 11.9 dB (
Tympanomastoidectomy in children with severe chronic otitis media improves hearing function and may be beneficial in some patients to cease otorrhea. This should be considered as a treatment option in children that have failed previous conservative management.
Discuss pediatric head and neck complications of invasive pneumococcal infections including the incidence, mean hospital cost, length of stay, and admittance from the emergency department before and after the PCV7 vaccine.
A retrospective cross-sectional analysis of the National Inpatient Database yielded (N = 31,738) pediatric incident reports involving meningitis, mastoiditis, otitis media, periorbital cellulitis, sigmoid sinus thrombosis, and bezold abscess due to invasive
We identified a significant decrease in the incidence of all described complications after the introduction of the PCV7 vaccine and also when compared to our predicted incidence calculations. Emergency department admittance for bezold abscess, periorbital cellulitis, mastoiditis, sigmoid sinus thrombosis and meningitis were significantly increased in the pediatric age group (ages 1-4) (
The PCV7 vaccine produced a measurable reduction in invasive pediatric pneumococcal complications of the head and neck. However, our data suggests these benefits were also met with increased emergency department admittance, hospital costs, and length of stay, each of which may be due to selection of a more invasive species.
Determine the current epidemiology of head and neck cancer in the US pediatric population.
The SEER (Surveillance, Epidemiology, and End Results) database was accessed to gather epidemiologic data regarding pediatric head and neck cancer between 1973 and 2010. Specific trends related to demographic background, histologic diagnosis, tumor location and incidence, as well as general trends of all pediatric cancers were extracted.
The total burden and incidence rates of pediatric cancer as well as head and neck cancer specifically continue to rise. Cancer was diagnosed in children under15 years of age at a rate of 12.5 (95% confidence interval [CI] 11.9-13.1) per 100,000 from 1973 to 1975 and 17.3 (95% CI 16.7-17.9) per 100,000 in 2007 to 2009, representing an increase of 38%. Head and neck cancers in the same age group increased from 1.1 (95% CI 1.0-1.3) per 100,000 in 1973 to 1975 to 2.0 (95% CI 1.8-2.2) per 100,000 in 2007 to 2009, a total increase of 81%. Despite this increased incidence, the proportion of head and neck cancers to all cancers in the pediatric population has remained stable.
Similar to pediatric cancer in general, the public health burden of pediatric head and neck cancer continues to rise. Although the proportion of head and neck malignancy to pediatric cancer in general is stable, the increasing incidence raises concern for potential underlying associations that may be amenable to intervention.
Determine prevalence of otitis media with effusion (OME) in school children and analyze relevant risk factors.
Through a cross-sectional study, 1488 children in the age range, 6 to 12 years were randomly selected from 25 primary schools. A questionnaire was used to determine risk factors for OME. Otoscopy and tympanometry were used to diagnose and confirm OME. Pure tone average for children with confirmed OME was measured. Teachers of the children were asked to complete a questionnaire evaluating child’s level of school performance. Those with or without OME were compared.
Prevalence of OME was 7.5% (112/1488). In univariate analysis, it was strongly associated with recurrent acute otitis media (AOM;
Prevalence of OME in Qassim region reaches 7.5% in school children. Young age, large family size, low maternal education, preschool AOM, hearing loss symptom, recurrent AOM, nasal discharge, and snoring are significant factors associated with the disease.
Determine whether various techniques used to promote tympanic membrane (TM) perforation closure at the time of ventilation tube removal impact the likelihood of TM perforation healing in children.
A retrospective chart review was conducted of 265 children (341 ears) who underwent tympanostomy tube removal at a tertiary care pediatric hospital between January 2010 and November 2013. Techniques performed at the time of ventilation tube removal included tube removal only, freshening the perforation edges, performing paper patch myringoplasty, or both freshening edges and paper patch myringoplasty.
The persistent TM perforation rate was 9.97% (34/341). Technique was not found to significantly influence the likelihood for the TM to heal (
There is no reduction in persistent TM perforation rate following ventilation tube removal if edges are freshened and/or a paper patch myringoplasty is performed. Increased pediatric age, longer-acting tympanostomy tubes and history of trisomy 21 may negatively influence the likelihood of closure.
A CAO (cholesteatoma extent, atelectasis degree and ossicle involvement) staging system for cholesteatoma was described at the XIII World Congress of Otorhinolaryn-gology in Florida in 1985. Because of 30 years of accumulated clinical data, we propose a revised and simplified model of stratification. This study aimed to investigate the prognosis of pediatric acquired cholesteatoma based on this revised staging system.
Between 1982 and 2012, 132 ears in 128 children (≤18 years of age) with acquired cholesteatomas after primary surgery were included. Each case was scored for cholesteatoma extent, history of grommet insertion, age, ossicular destruction, and otorrhea. The total score classified the patients as stage I (5-6 points), stage II (7-9 points) or stage III (10-12 points). The staging system was applied to the first (66 ears) and second (66 ears) halves of the cohort, and the entire cohort (132 ears). Differences between stages were compared using Kaplan-Meier cumulative recidivism curves.
The mean follow-up period was 12 years. The 15-year cumulative recidivism rate was 19.6% overall, 0% in stage I, 10.4% in stage II, and 30.6% in stage III. The cumulative recidivism curves were well stratified by stage, with differences reaching statistical significance in the second half and entire cohort (
The proposed revised staging classification may adequately stratify patients regarding the prognosis, facilitating the identification of children at risk of recidivism. Further external validation on an independent data set is warranted before broad application can be recommended.
Over the past decade, thoracic slide tracheoplasty (TST) has become the principal operation in the management of congenital tracheal stenosis. The purpose of this report is to (1) describe our experience with revision TST following unsuccessful prior tracheal reconstruction and (2) compare our outcomes with primary TST.
Patients undergoing TST on cardiopulmonary bypass between January 2005 and 2014 were reviewed. Patients with a history of prior airway surgery were extracted for further analysis. Preoperative patient variables and postoperative outcomes were evaluated.
A total of 108 patients were reviewed over the study period. Twenty-two revision patients (20 referrals, 2 primary patients) met inclusion criteria. Eighteen patients had a history of complete tracheal rings and 4 patients had cartilaginous deficiency. A total of 35 tracheoplasties (rib graft = 6; slide tracheoplasty = 5; pericardial patch = 4; homograft = 3;resection = 1; cricoid split = 1; combined tracheal reconstruction = 15) had been performed prior to revision TST. Following revision TST, additional endoscopic interventions were required in 5 patients (23%). Twelve balloon dilations (average 2.4 per child) and 4 endoscopic stent placements were performed in these 5 patients. The majority (68%) of children required <48 hours of ventilator support following revision. There was one nonsurgical postoperative mortality.
Despite some differences in the postoperative management when compared to nonrevision cases, revision TST can be successfully performed after prior tracheal reconstruction with good postoperative outcomes.
(1) Determine whether intraoperative tympanostomy tubes (TT) during surgery for acquired retraction pocket cholesteatoma (ARPC) results in improved hearing outcomes or decreased recurrence of ARPC. (2) Determine the need for subsequent TT in children that did not receive TT at initial surgery.
Institutional review board–approved retrospective review of children 4 to 18 years, who underwent primary surgery (tympanoplasty or tympanomastoidectomy) for ARPC at a tertiary care children’s hospital from January 1, 2000, to December 31, 2012. Audiometry, operative reports, office findings, TT, and recurrence data for ARPC were analyzed. The chi-square test was used for statistical analysis.
Preoperative Mills staging for extent of cholesteatoma was similar for both groups. A total of 24 patients had TT at initial surgery (TT Group) and 34 patients did not (no TT Group). The average preoperative and postoperative SRT were 23dB and 25dB, respectively, for the TT Group, and 31 dB and 31 dB for the no TT Group. The recurrence rate for ARPC was 29% for the TT Group versus 41% for the no TT Group (
There was no statistical difference in recurrence or audiometric outcomes between patients who underwent TT insertion versus those who did not during initial surgery for ARPC. However, since the incidence of recurrent ARPC was 12% lower when TT were placed, and since the rate of subsequent TT was 35% in the no TT Group, a larger, prospective study of TT at initial surgery for ARPC is needed.
(1) Define the evolution of palatal vascularization during palatal shelf formation and effects of vascular endothelial growth factor (Vegf) deletion in the cranial neural crest. (2) Determine downstream mediators of Vegf signaling.
Conditional deletion of Vegf using Wnt1-Cre; Vegf F/F mice (VegfCKO) led to a cleft palate phenotype. PECAM staining was used to determine vascular patterning in the VegfCKO developing palate daily from E13.5 to E16.5 compared to controls. The VegfCKO palate shelves at E13.5 and E14.5 were analyzed using quantitative PCR (qPCR) to assess mediators and targets of Vegf signaling.
VegfCKO had aberrant vascular branching via PECAM staining in comparison to controls. In E13.5 VegfCKO mice, there were no significant differences in mediators and targets of VEGF signaling measured by qPCR. However, at E14.5, VegfCKO palates demonstrated significant reductions in pyruvate dehydrogenase kinase (PDK4) (
Vegf was required for palatal vascularization and palatal elongation. During palatal development Vegf was upstream of SDF1, a cytokine necessary for endothelial progenitor cell recruitment and migration. Vegf also modulates glycolysis through variations in PDK4, a protein involved in glucose metabolism.
(1) Determine whether the change in obstructive sleep apnea (OSA)-18 pre- and posttonsillectomy could serve as a measure of surgical success. (2) Determine the practicality of administering pre- and posttonsillectomy OSA to a valid patient sample. Obstructive Sleep Apnea 18 (OSA-18), a validated instrument, assesses quality of life (QOL) relative to severity of sleep-related problems. Higher OSA-18 scores are associated with poorer QOL.
Prospective, case series methodology at a tertiary pediatric hospital. Patients undergoing tonsillectomy ± adenoidectomy for sleep-disordered breathing (SBD). Two distribution-collection methods were trialed attempting to systemize the process. In phase one (14 months) we collected pre-intervention scores during the ambulatory clinic visit. In phase 2 (8 months) a single provider distributed pre-intervention instruments to parents on the day of surgery. Both methods sent post-tonsillectomy instruments using a web-based tool.
In phase 1, 348 pre-intervention instruments were collected. Fifty-eight (16%) met inclusion criteria, and of these, 22 (38%) completed the postintervention instrument. In phase 2, 11 pretonsillectomy scores were collected, and 6 (55%) of these completed the posttonsillectomy instrument. In both groups, the average change in OSA-18 was 33 points (1: 65 pre, 31 post; 2: 61 pre, 29 post, respectively).
The OSA-18 instrument demonstrates tonsillectomy +/- adenoidectomy is very successful at improving pediatric OSA-related QOL. These data could document the value of the procedure. However, collecting pre- and post-intervention scores from busy parents is operationally burdensome and only modestly successful. Use of change in OSA-18 as an outcome metric will require a yet-to-be-determined strategy to reliably collect pre-and post-surgery scores.
(1) Describe the treatment options for severe bronchomalacia. (2) Learn about a novel technology for treatment of severe bronchomalacia using a 3-dimensionally (3D) printed patient-specific external bronchial splint.
A 16-month-old patient previously underwent tracheostomy for severe bronchomalacia but had been unable to be discharged home since birth because of persistent high ventilatory requirements (PEEP 20). Despite high ventilatory settings and intravenous sedatives, respiratory events required prolonged intensive care unit (ICU) care and intermittent comas. Endoscopic examination demonstrated focal bilateral mainstem bronchomalacia. DICOM CT images of the patient’s airway were imported into a computer-aided modeling program and custom 3D external bronchial splints were created utilizing image-based Boolean design. The splints were 3D printed using poly-L-caprolactone. Institutional Review Board and Food and Drug Administration emergency-use exemption was granted and the patient was implanted with the custom devices.
Subsequent bronchoscopy revealed patency of both mainstem bronchi and normal ventilatory variation in both lungs. Peak end-expiratory pressure (PEEP) was immediately weaned from 20 to 10 mm Hg and tidal volumes immediately improved from 5 to 10 cc/kg. The patient is actively being weaned from ventilator support. Respiratory parameters, endoscopy, and dynamic imaging are being actively studied during the patient’s recovery.
This patient demonstrates a clinical scenario of bilateral bronchomalacia who had exhausted conventional treatment options but necessitated prolonged ICU-level support. The creation of 3D-printed external bronchial splints has alleviated the critical nature of the bronchomalacia and represents the first time this technology has been used in a patient with bilateral disease.
There is a paucity of data regarding postoperative complications associated with pediatric otologic procedures. We describe safety and postoperative sequelae of these procedures using data from the largest quality improvement initiative in pediatric surgery, the American College of Surgeons National Surgery Quality Improvement Program-Pediatric (NSQIP-P). This study is the first to assess safety of pediatric otologic surgery using NSQIP-P data.
We identified children who underwent outpatient otologic surgery using current procedural terminology codes. Variables of interest included patient demographics and 30-day unplanned postoperative events including reoperation, readmission, and wound complication. Adverse event rates were determined and prevalence of events was compared by procedure type and within patient subgroups.
Of 37,319 pediatric surgical cases, 2410 were otologic procedures. The most common procedure was tympanoplasty (N = 836, 34.7%), followed by myringoplasty (N = 741, 30.7%), tympanomastoidectomy (N = 630, 26.1%), and cochlear implantation (N = 464, 19.3%). There were 7 reoperations (0.3%), 30 readmissions (1.2%), and 17 wound complications (0.6%). Cochlear implantation had the highest readmission and reoperation rates (12/464, 2.6% and 3/464, 0.7%) of the procedures studied, followed by tympanomastoidectomy (8/630, 1.3% and 3/630, 0.5%). There was not enough power to determine statistical significance of patient characteristics that increased risk of adverse event.
Pediatric otologic procedures are commonly performed and have extremely low rates of postoperative 30-day complications. Although NSQIP-P is a powerful, nationally recognized quality platform, optimization is necessary for assessment of meaningful procedure-specific outcomes in pediatric otologic surgery. Analysis of pooled NSQIP-P data across future years may guide determination of predictive factors for an adverse event.
(1) Compare height and weight changes of children who underwent tonsillectomy and adenotonsillectomy (T&A) with a control group. (2) Analyze differences in growth based on starting weight class.
A total of 154 children who underwent T&A between December 2010 and March 2011 were included. They were compared with 182 children with similar demographics who were seen in primary care clinics (control). Height and weight were compared at 6-month intervals over a 24-month period. Patients were divided into normal weight, overweight, and obese based on Centers for Disease Control and Prevention criteria. A multilevel regression model was used for analysis. Significance was set at
There were no differences in average starting weight, age, or sex between surgical and nonsurgical groups. Average starting weight was 47.6 kg (confidence interval [CI] 42.0-53.2) and 48.1 kg (CI 41.8-54.3) for the obese surgical and obese control groups respectively. There was no difference in weight gain at 6 months. However at 12, 18, and 24 months, the obese surgical group had a significant weight increase over and above the obese control group (
T&A leads to significant increase in weight in obese but not in normal or overweight children. Efforts should be made to provide weight reduction counseling prior to T&A in obese children.
Evaluate the correlation between surgical instrumentation and intraoperative surgical time, postoperative hemorrhage and associated health care cost for pediatric adenotonsillectomy.
Retrospective chart analysis from a tertiary care pediatric hospital of patients who underwent adenotonsillectomy from 2011 to 2013. Monopolar electrocautery, radiofrequency ablation, and PlasmaBlade instruments were compared for intraoperative surgical time and postoperative hemorrhage rate. Univariate analysis of variance (ANOVA) and chi-square analysis was used to evaluate differences between instrumentation and variables. Cost analysis examining instrumentation and intraoperative anesthesia was also reviewed.
A total of 1280 patients who underwent adenotonsillectomy were evaluated. There was no significant overall difference in age, sex, or preoperative diagnosis identified between the 3 instrumentation groups. When examining the various instruments’ effects on procedure time in minutes, univariate ANOVA did demonstrate a significant difference overall between the 3 groups (
The ideal surgical instrumentation would be efficient, have a low complication rate, and be relatively inexpensive. Monopolar cautery was associated with a statistically significant lower intraoperative surgical time, similar postoperative hemorrhage rates and lower operative costs when compared to radiofrequency ablation and PlasmaBlade.
Allergic fungal rhinosinusitis (AFRS) is well known to expand and to extend to the surrounding structures like the orbit and the brain; however, it has not been reported to extend to the infratemporal fossa (ITF). Because of the difficulty of accessing the ITF, we report our experience over 5 years.
One hundred one patients with AFRS were operated upon by the author between 2008 and 2013.
All of these patients had preoperative computed tomography scans (CTs), and all but 2 had postoperative CT of the paranasal sinus. Twelve had expansion or extension of the disease into the ITF: 8 males and 4 females, their ages ranged from 10 to 34 years with mean of 20.4 years. Four of them were children below 15 years of age. Three patients had bilateral disease and 9 had unilateral sinus involvement. Seven cases had expansion of the posterior wall of the maxillary sinus into the ITF, which was unilateral and mil; however, extension from the sphenoid sinus was more extensive in most of the cases; bilateral in 2 and unilateral in the others.
ITF extension from the sphenoid sinus is more extensive than from the maxillary sinus. In a pediatric population, because of the incomplete fusion of the suture line, the disease expanded and eroded into the ITF. In adults, the opticocarotid recess is the weakest area and the disease can expand through it into the ITF. Posterior wall of maxillary sinus expansion into the ITF is mild in all cases, and all the ITF extensions were cured endoscopically.
(1) Analyze the clinical characteristics of upper respiratory infections (URIs) complicated by acute bacterial sinusitis (ABS) in young children. (2) Describe the bacteria and viruses isolated in nasopharyngeal specimens in children with ABS.
We identified ABS episodes in a prospective, longitudinal cohort study of 294 children (aged 6-35 months at enrollment), who were followed up for one year to capture all URI episodes and complications. At the initial URI visit (median day = 4), nasopharyngeal samples were obtained for bacterial cultures and viral studies. The study was conducted at the University of Texas Medical Branch, Galveston, during 2003-2007.
Of 1295 documented URI episodes, 103 (8%) episodes (in 73 children) were complicated by ABS, 32 of which were concurrent with acute otitis media. The majority (72%) of ABS episodes were diagnosed based on persistent symptoms or a biphasic course. The average age was 18.8 ± 7.2 months; white children were more likely to have ABS episodes than blacks (
ABS complicates 8% of URIs in children. Girls have more frequent ABS episodes than boys. Presence of rhinovirus and
(1) Evaluate the anatomic variability of the distance between the internal carotid arteries (ICA) at the paraclival, intracavernous, and paraclinoid segments in normal variants and in patients with sellar or parasellar lesions. (2) Identify clinicopathologic factors associated with a reduced intercarotid distance (ICD) and identify subgroups at higher risk for ICA injury during endoscopic skull base surgery.
A retrospective case-control study was performed at an academic tertiary care center. The smallest distance between the ICAs at the paraclival, intracavernous. and paraclinoid segments on coronal T2-weighted magnetic resonance imaging was measured in patients with sellar or parasellar tumors and in nontumor controls. Factors such as demographic profiles, cephalometric measurements, tumor dimensions, and sphenoid configuration were assessed as potential predictors of the ICD.
In total, 154 cases and 34 controls were analyzed. Patients with growth hormone (GH) secreting adenomas had a markedly reduced ICD at the paraclival segment as compared to controls (1.59 cm and 1.77 cm, respectively;
Patients with a GH secreting adenoma or planum sphenoidale meningioma had a reduced ICD. Identifying these populations can help surgeons recognize constraints imposed by a reduced ICD to endoscopic access of the skull base and avoid inadvertent ICA injury.
Although a relationship between elevated cerebrospinal fluid (CSF) pressure and spontaneous CSF leaks has been reported, analyses by anatomic sub-site are lacking. This study seeks to elucidate the association between physiologic parameters and CSF leak location.
Prospective case series of patients undergoing endoscopic endonasal repair of spontaneous CSF leak between 2004 and 2013. All participants had a lumbar drain placed for 24-hour continuous preoperative pressure monitoring, and 24 hours of continuous monitoring starting 48 hours after the repair. In addition to patient characteristics, mean and peak CSF pressures by anatomic location were calculated and compared.
Twenty-five patients underwent perioperative CSF pressure monitoring, with a mean follow-up of 526 days. Nine patients had CSF leaks along the cribiform plate, 4 in the ethmoid roof, 8 in the sphenoid, 2 in the posterior table of the frontal sinus, and 2 with multiple leaks. Patients with cribiform leaks had the lowest mean body mass index (BMI) and prevalence of obstructive sleep apnea (22.2%), while those with multiple sites of leak had the highest mean BMI and prevalence of obstructive sleep apnea (50%). Patients with frontal sinus leaks had the highest postoperative mean (14.47 mmHg) and peak (42.5 mmHg) CSF pressures, while ethmoid roof had the lowest mean (0.43 mmHg) and peak (16.45 mmHg) CSF pressures.
CSF pressure and other physiologic characteristics differ among patients with spontaneous CSF leaks by anatomic location. Understanding these differences may enable treatment approaches tailored by leak site, thereby improving repair outcomes.
For the past few decades, endoscopic sinus surgery (ESS) combined with medication therapy has improved the prognosis of chronic rhinosinusitis with nasal polyps (CRSwNP). However, we sometimes encounter refractory CRSwNP complicated with nonatopic asthma and tremendous eosinophil infiltration in nasal polyps. Recently, enterotoxin of
Total IgE and IgG and SAE-A, B, Aspergillus, Candida and Alternaria-specific IgEs and IgGs production in ethmoid sinus mucosa were analyzed and compared to such data in blood serum and the results of skin tests in operation cases with CRSwNP in our university hospital. Ethmoid sinus mucosa was obtained during operation and kept in liquid nitrogen followed by mashing in 1 mL phosphate-buffered saline (PBS). After centrifugation of this PBS, the supernatant was harvested in each case to analyze total and antigen-specific IgEs and IgGs based on the weight correction of each sample.
In the skin tests, positive reaction was often observed only to Candida 48 hours after injection. While local fungi-specific IgEs were little, local SAE-A,-B-specific IgEs were apparently positive and local total IgE level was elevated. Candida specific Ig G and/or SAE-A, -B specific IgE dependent reactions may play important roles in the pathophysiology of refractory CRSwNP.
Airplane cabin supply air has been shown to have multiple possible respiratory irritants. In addition, changes in barometric pressure in flight may contribute to some respiratory conditions. Therefore, there may be an association between commercial airline flight and sinus disease.
Participants of the Secondhand-Smoke, Air Quality and Respiratory Health Among Flight Attendants study cohort were mailed a questionnaire pertaining to their flight experience and respiratory health. Working years, working days per month, and number of trips per month were quantified, as well as smoking exposure history and self-reported physician diagnoses of sinusitis, asthma, and rhinitis. The sinonasal outcomes were quantified using a Respiratory Questionnaire Score (RQS). Multivariable analyses were performed to analyze the associations between flight time and sinus disease.
A total 579 participants met the inclusion criteria, with cohort prevalence of sinusitis, asthma, and rhinitis of 24.8, 13.1, and 20.4%, respectively. There was a significant trend of increasing odds ratios (OR) of sinusitis and rhinitis with increasing working years tertiles (
This is the first study to analyze the relations between airline flight time and sinonasal disease. Sinusitis diagnosis, numerous sinonasal symptoms, and cumulative symptom scores were all shown to be significantly associated with flight time.
(1) Determine general practitioners’ (GP) awareness of the guidelines for allergic rhinitis (AR) and identify any factors influencing their awareness of the guidelines. (2) Assess their diagnosis, treatment protocol, and understanding of co-morbidities of AR.
A cross-sectional questionnaire-based study was performed between November 2012 and July 2013. One hundred one GPs from 23 practices completed questionnaires as part of educational briefing with a response rate of 97% (101/104). One hundred copies met the criteria.
Only 7 out of 100 GPs (7%) were aware of the Allergic Rhinitis and its Impact on Asthma (ARIA) or related AR guidelines; therefore, the prevalence of awareness of the guidelines is 0.07 (95% confidence interval 0.03 to 0.14). A further 13% (13/100) knew of local guidelines which were not for AR. Most GPs knew the treatment for mild and moderate-severe AR (93% and 77% respectively). A higher percentage of GPs with previous ear, nose, and throat (ENT) experience (97% and 84% for mild and moderate-severe respectively) were aware of the treatment. Forty-one percent of GPs did not know the link between AR and asthma. A significant number of GPs with previous ENT experience (
Education of GPs, including more ENT experience and workshops, is required to increase awareness of the guidelines. These will improve management of AR.
Salubrious effects of the green coffee bean are purportedly secondary to high concentrations of chlorogenic acid (CA). CA has a molecular structure similar to bioflavanoid polyphenols known to activate transepithelial Cl- transport in sinonasal epithelia. In contrast to bioflavonoids, chlorogenic acid is freely soluble in water. The objectives of this study are to evaluate the Cl- secretory capability of CA and potential as a therapeutic activator of mucus clearance in sinus disease.
CA was tested on primary murine nasal septal epithelial (MNSE) [CFTR+/+ and transgenic CFTR-/-] and human sinonasal epithelial(HSNE) [CFTR+/+ and F508del/F508del] cultures under pharmacologic conditions in Ussing chambers to evaluate effects on transepithelial Cl- transport. Changes in airway surface liquid depth and CFTR mRNA transcription were also measured.
CA stimulated transepithelial Cl- secretion [(change in short-circuit current(^†ISC)] in MNSE (13.11 ± 0.9 vs 0.1 ± 0.1,
CA is a water-soluble agent that promotes CFTR-mediated Cl- transport in sinonasal epithelium. Further in vivo evaluation as a therapeutic activator of mucus clearance is planned.
(1) Examine the discriminant validity of 2 validated assessment tools in endoscopic sinus surgery (ESS) training. (2) Compare the binary versus the 5-point Likert-scale tools in ESS assessment.
A cross-sectional study was conducted from February-August 2013. All otolaryngology trainees in the North-London training program were assessed while performing ESS on sheep heads, which previously showed face and content validity. Performance was rated by 2 blinded assessors using 2 validated tools: The Inter-Collegiate-Surgical-Curriculum-Project tool, which utilizes a binary system and is used throughout the UK surgical training system, and the John Hopkins 5-Point Likert scale ESS tool. The tools’ construct validities were tested by comparing performance of experts and novices. The tools were also tested by correlating task-specific and global skills ratings with overall performance level.
The binary tool showed higher inter-rater reliability than the Likert scale, both in task-specific (Kappa: 0.89 versus 0.62) and global skills (Kappa: 0.79 versus 0.68) rating. Both tools discriminated between different levels of expertise in global and task-specific skills (Kruskal-Wallis:
While the binary assessment tool may show higher inter-rater reliability and is easier to complete, the Likert scale, when each level is well defined, showed good agreement and better construct validity, which can be useful when monitoring progress in training.
Although intracranial extension of angiofibromas is not uncommon, intradural penetration is rare. Management of such rare tumors is a challenging issue in skull base surgery, necessitating tumor removal via combined approaches in most cases. In this paper we present our experience for management of extensive intradural angiofibromas.
Six cases were male patients, 5 between 15 and 19 years old, presenting with nasal obstruction and epistaxis and proptosis. One of them was an aggressive recurrent tumor in a 32-year-old patient. They were scheduled for combined approaches with assistance of image-guided endoscopic surgery.
Six cases underwent combined transnasal, tramaxillary, and craniotomy approaches with assistance of image-guided endoscopic surgery. Craniotomy preceded rhinologic approach in 3. CSF leak and skull base defect was repaired by temporalis muscle flap and pericranial flap in 4 and fascia lata in 2. One postoperative leak was repaired with fascia lata transcranially. Otherwise the course was uneventful in all cases.
The intradural intracranial extensions of angiofibroma require meticulous approach in terms of surgery because of their greater risk for complications during the dissection. Carotid rupture and brain damage are 2 catastrophic complications which should be kept in mind. In cases with extensive intradural involvement of the middle cranial fossa by angiofibroma, craniotomy with intradural approach could help to decrease complications.
(1) Describe clinical and histopathologic findings in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). (2) Determine if tissue and serum eosinophilia predict disease severity in CRSwNP.
Patients with CRSwNP treated at an academic hospital specializing in respiratory and allergic disease from 2008 to 2010 were included in this study. Clinical information was collected retrospectively. Sinus computed tomography (CT) scans were scored by a single author according to the Lund-Mackay (LM-CT) system, and surgical specimens were evaluated by a single author for degree of tissue eosinophilia. Statistical analysis was performed with
Seventy CRSwNP patients were included. They had a mean LM-CT score of 16.7, 62.1% of patients had severe asthma, and 62.9% were aspirin sensitive. There was no significant correlation between tissue and serum eosinophil counts (
Higher serum eosinophil levels may indicate worse mucosal disease as measured on CT scan, but neither serum nor tissue eosinophilia predicted disease severity in our population CRSwNP patients.
This study is part of the Chronic Rhinosinusitis Epidemiology Study (CRES). The overarching aim is to determine factors that influence the onset and severity of chronic rhinosinusitis (CRS).The aim of this analysis is to determine the number of patients consulting with their family physician about anxiety or depression among those with CRS and controls.
CRES is a mixed methods study of patients with CRS including qualitative interviews and study-specific questionnaires. This analysis considers only the questionnaires. These included comprehensive questions about demographic and socioeconomic factors and past medical history as well as SNOT-22 (nasal symptom score) and SF-36 (quality of life tool). Questionnaires were distributed to patients with CRS attending general ENT and rhinology clinics within the National Health Service and private sector and to a control population across many centers in the United Kingdom from 2004 to 2013.
A total of 1519 participants, including 57 with AFRS (allergic fungal rhinosinusitis), 659 CRSwNP (with nasal polyps), 577 CRSsNP (without nasal polyps), and 236 controls. Self-reported consultation with family physician for depression was 9 out of 57 (15.8%), 132 out of 659 (20.0%), 142 out of 577 (24.6%), and 36 out of 226 (15.9%), respectively.
There are differences in rates of consulting with family physicians for depression and anxiety disease between those with different types of CRS and controls; those with CRS without polyps were most likely to have consulted. This may influence management strategies for patients with different nasal pathologies.
Analyze the correlation between preoperative nasal nitric oxide (nNO) level, its postoperative change, and symptom scores in patients with chronic rhinosinusitis (CRS).
We collected pre- and postoperative 3 and 6 months nNO level for patients who received bilateral endoscopic sinus surgery. They were classified according to existence of nasal polyps (NPs) and allergy test. Subjective symptoms were provided as Sino-Nasal Outcome Test-22 (SNOT-22) and Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ). Associated medical parameters were analyzed.
Fifty-four patients completed the follow-up, including 16 CRS without NPs (CRSsNPs) and 38 CRS with NPs (CRSwNPs). Allergic patients had higher preoperative nNO level (
Baseline nNO was significantly correlated to some of the symptom improvements in CRSwNPs and nonallergic group within 3 months postoperatively. Postoperative 3 month nNO change related to olfaction improvement in CRSwNPs group; however, no significant correlation could be detected in the 6-month period after surgery.
Active anterior rhinomanometry (AAR) and the Nasal Obstruction Symptom Evaluation (NOSE) scale are instruments for measuring nasal obstruction (NO). The study aimed to measure therapeutic success in the patients with NO by AAR and NOSE scale and establish the correlation between AAR and NOSE scale and between NOSE scale and visual analogue scale (VAS).
Cohort study of patients with NO, on whom we performed an AAR, the NOSE scale, and the VAS at baseline and after medical treatment (topical nasal steroid) or surgery (septoplasty, turbinoplasty, or septoplasty and turbinoplasty). The nasal flows obtained by the AAR and the score of both subjective scales (NOSE and VAS) were compared and analyzed.
A total of 102 patients were included in the study. Surgical treatment resulted in statistically significant differences with AAR and the subjective scales (
There is a higher treatment success in patients treated surgically. There is no significant correlation between AAR and NOSE scale and VAS. This is considered because the AAR and subjective scales are complementary and they measure different aspects of NO. Therefore, the AAR and the NOSE scale are helpful instruments to be used together for the diagnosis of NO and to measure objective therapeutic success and the feeling of satisfaction by the patient.
Frontal sinus osteomyelitis is a severe complication that can result from chronic rhinosinusitis, from trauma, or as a complication of reconstruction or obliteration of the frontal sinus. The objective of the current study is to evaluate the contemporary management of frontal sinus osteomyelitis in light of recent pervasive advancements in endoscopic experience.
Review of a prospectively collected database of patients with frontal sinus pathology was performed from 2008-2013, and data from individuals with frontal sinus osteomyelitis were collected regarding demographics, etiology, surgical technique, adjunctive medical treatments, complications, and clinical follow-up.
Eleven patients (average age, 43.6 years; range, 8-84 years) were included in the study. An open approach was used in 5 patients (2 osteoplastic flaps, 2 Reidel procedures, 1 cranialization). Four patients underwent completely endoscopic approaches (2 Draf IIB, 2 Draf III), while 2 individuals had combined procedures (Lynch/Draf III, osteoplastic flap/Draf III). Osteomyelitis was secondary to complications from previous surgery (n = 6) and acute/chronic rhinosinusitis (n = 5). An open approach was used in all cases of osteomyelitis that formed as a result of prior surgery. All patients received 6 weeks of intravenous antibiotics. Average clinical follow-up was 8 months with no revision procedures.
Endoscopic, endoscopic-assisted, and open approaches were used successfully in the current series of patients with osteomyelitis of the frontal bone. While the advent of endoscopic techniques allows an additional surgical treatment option, it is important to select patients appropriately as open procedures continue to have a role in the treatment algorithm.
Using a patient cohort with chronic rhinosinusitis (CRS) refractory to medical management, evaluate the impact of early versus delayed endoscopic sinus surgery (ESS) in terms of postoperative health care utilization.
The MarketScan CCAE database was queried. Patients with ESS in 2010 and complete medical history from 2004 to 2012 were identified. Diagnoses of CRS or polyposis prior to 2005 as well as ESS prior to 2010 were exclusion criteria. Patients were characterized by time interval of first CRS diagnosis to ESS and grouped as follows: (1) <1 year (N = 888); (2) 1-2 years (N = 267); (3) 2-3 years (N = 300); (4) 3-4 years (N = 414); and (5) 4-5 years (N = 649). Outpatient visits/procedures and prescriptions associated with CRS were analyzed for all groups at the following time points: year immediately preoperative, year 1 postoperative, and year 2 postoperative.
Patients in all groups showed significant decline in health care utilization following surgery. Groups 1 and 2 had significantly fewer health care needs pre- and postoperatively compared to Group 5. Specifically, Group 1 had an average of 3.45 visits (95% confidence interval [CI]: 3.31-3.58) and 2.92 filled prescriptions (95% CI: 2.71-3.14) preoperatively versus Group 5 (visits: 4.57 (95% CI: 4.37-4.78); prescriptions: 4.69 (95% CI: 4.33-5.05)). At year 2 postoperative, Group 1 had 0.92 visits (95% CI: 0.74-1.10) and 0.82 prescriptions (95% CI: 0.67-0.96) versus Group 5, with 1.78 visits (95% CI: 1.45-2.11) and 2.06 prescriptions (95% CI: 1.73-2.39).
Patients treated surgically early in the diagnosis of CRS have lower health care needs than patients treated after many years of failed medical management.
Assess the effect of perfume on olfactory detection thresholds of health workers at the University College Hospital, Ibadan.
This was a quasi-experimental study on olfactory detection thresholds of one hundred healthy health workers in a tertiary health institution from September 2013-November 2013. A structured questionnaire was administered to participants to obtain information on sociodemographics, occupation, ability to perceive smell, use of perfume, effects of perfume on appetite and self-confidence, history of allergy, and previous nasal surgery. Participants subjectively rated their olfactory performance and thereafter had olfactory detection threshold testing done with varied concentrations of n-butanol in a forced triple response and staircase fashion. Olfactory detection thresholds at baseline and after exposure to Lynx perfume were determined and compared.
Thirty-seven males and 63 females were evaluated. Their ages ranged from 19-59 years with a mean age 31 years ± 8. Subjectively, 94% participants had excellent olfactory function. In the pre-exposure forced triple response, 88% participants were able to detect the odor at ≤0.25 mmol/L concentrations while in the post-exposure forced triple response, only 66% participants were able to detect the odor at ≤0.25 mmol/L concentrations. There was also a statistically significant difference in the olfactory detection threshold score between the pre-exposure and post-exposure period in the participants (
Use of fragrance affects the olfactory detection threshold. Therefore, wearers should be aware of this and its implications on test of olfaction.
(1) Quantify the changes in the number of ciliated cells, ciliary beat frequency, and mucociliary transport of the nasal mucosa in smokers. (2) Evaluate if these cytologic and functional changes in smokers are permanent or reversible after smoking cessation.
Ninety healthy volunteers recruited from the staff of A. Fiorini Hospital, Sapienza University of Rome, were enrolled in this study from September 2013 to January 2014. Volunteers were divided into 3 groups (smokers, nonsmokers, and ex-smokers) composed of 30 subjects each. Cytological features of nasal mucosa and effectiveness of nasal mucociliary clearance were studied focusing on 4 parameters: 1) ratio between the number of ciliated cells and mucous-secreting cells analyzed through microscopic observation of nasal scraping specimens; 2) in vitro evaluation of ciliary motility; 3) survival time of the ciliated cells analyzed by phase-contrast microscopy; 4) nasal mucociliary clearance assessed by saccharin transit time test.
All parameters are significantly reduced in the group of smokers compared to the nonsmokers (
Cigarette smoking causes cytological modifications of nasal mucosa that influence the effectiveness of mucociliary clearance. Our study, although preliminary and conducted on a limited number of cases, suggests that these changes are not permanent and that nasal mucosa of ex-smokers would recover normal cytologic and functional features.
To report: (1) Oncological safety of endoscopic technique using disease free survival and a Kaplan Maier analysis for malignant tumors and recurrence rate for benign tumors; (2) Type of reconstruction of large anterior skull base defects and rate of postoperative cerebrospinal fluid leak; (3) Postoperative major (cranial and orbital) and minor complications.
Retrospective chart review identifying patients undergoing endoscopic anterior skull base resection for malignant and benign tumors at a tertiary care medical center between September 1997 and June 2013.
Preliminary analysis shows that 34 patients underwent transnasal endoscopic resection for malignant disease and 2 patients for benign disease. The median follow-up was 30 months. Olfactory neuroblastoma was the most common pathology. There were 3 major and 5 minor complications. Three patients recurred locally resulting in a local control rate of 90.9%. The overall mortality rate was 18%, and the disease specific mortality was 3%. Reconstruction of the skull base defect was done using acellular dermis as a sole graft with a success rate of 97% and a cerebrospinal fluid leak in 1 case.
Endoscopic anterior skull base resection for benign or malignant disease is a safe and valid alternative compared to standard approaches. It is gaining more popularity, and with increasing surgical expertise, the indications of this procedure are expanding.
(1) Recognize the impact of nasal vibrissae on subjective and objective measures of nasal obstruction. (2) Apply presented data to make informed recommendations to patients regarding vibrissae reduction as an adjunct or alternative to other treatments for nasal obstruction.
In this prospective study, 30 healthy participants without nasal symptoms were assessed for baseline vibrissae concentration and treated with a topical decongestant. Subjects were then asked to subjectively assess nasal breathing using the NOSE instrument prior to undergoing rhinomanometry. Nasal vibrissae were then trimmed, and participants repeated the subjective and objective assessments. Pre- and post-intervention outcomes including NOSE values, airflow, and resistance were compared using statistical analysis.
Statistically significant improvement was noted in subjects’ NOSE assessment of nasal obstruction (80% average improvement,
In these 30 subjects, strong statistically significant improvement occurred in both subjective and objective assessments of nasal obstruction, particularly in patients with more dense vibrissae. These data suggest consideration of reduction of vibrissae density in patients complaining of nasal obstruction. Furthermore, the role of nasal vibrissae should be considered in any study examining the impact of medical or surgical interventions on nasal obstruction.
The goals of pituitary tumor resection include normalizing endocrine function, relieving mass effect, and minimizing risk of recurrence. This study sought to determine the effect of surgical approach “transsphenoidal or transfrontal” on outcomes.
Retrospective review of the 2008-2011 Nationwide Inpatient Sample for patients undergoing pituitary lesion resection. Hospital and patient demographics and outcomes were compared between transfrontal and transsphenoidal surgical approaches.
A total of 8543 admissions for resection of pituitary lesions met our inclusion criteria. Most (>90%) were treated transsphenoidally. The transfrontal approach was most frequent in the young (<35 years) and in the South. Transfrontal resection led to significant increases in mortality and complications including central diabetes insipidus, iatrogenic panhypopituitarism, and intracerebral hemorrhage. Multivariate analysis found transsphenoidal resection reduced hospital costs and length of stay by over 50%; low-volume hospitals increased cost and length of stay. There was an increased rate of transfrontal approaches at low-volume centers.
Multiple factors influence outcomes of pituitary tumor resection. Case specifics, including tumor location and size, influence approach and lead to a selection bias that cannot be controlled for in the present study. The prevalence of transfrontal resections at low-volume centers may indicate that surgeon familiarity rather than contraindication to transsphenoidal surgery serves as the basis for surgical planning.
(1) Demonstrate our endonasal procedure to totally remove advanced sinonasal inverted papilloma (SIP). (2) Show the successful outcome in the long-term follow-up study.
A retrospective study. Forty-six sides of the 45 patients with SIP were operated on for the last 13 years. Nineteen of the 45 patients showing advanced stage (III:17 and IV:2 in Krouse’s staging) were enrolled in this study. They consisted of 11 men and 8 women, and the age ranged from 28 to 92 years old. Endoscopic endonasal sinus surgery with aid of supplementary techniques described below was performed in all patients.
Extranasal methods were not required in this study. Transinferior turbinate approach to the anterior part of the maxillary sinus was applied to 5 of the 11 patients where SIP originated from the maxillary sinus. Endonasal medial maxillectomy was added to 2 of the 5 patients because of the inferior turbinate invasion. Draf type IIb or III procedure was applied to 4 of the 5 patients in whom the frontal sinus was involved. In 2 patients who showed the sphenoid sinus invasion, transseptal approach was used. During the 15 to 122 months follow-up period, recurrence was seen in 2 patients in whom simple ESS procedure had been performed in the maxillary sinus.
Our endonasal removal procedure for advanced SIP is acceptable, and may be alternative to extranasal methods, although longer follow-up study is required.
Participants should be able to: (1) Recognize factors contributing to failure; (2) Describe techniques required for a safe/successful surgery; (3) Implement postsurgical medical treatment enhancing long term outcome.
Results with the endoscopic Modified-Lothrop were reviewed. Although the success rate is good for revision sinus surgery (90%), factors contributing to failure such as allergy, mucosal reactivity, and scar formation were investigated. The senior author’s series of 104 endoscopic modified Lothrops completed between January 1997 and October 2013 were reviewed for patency of the frontal floor drainage, mucosal condition, and symptomatology. The Lothrop procedure was first reported in 1914 using an external incision. Draft in 1991, Close in 1994, and Gross in 1995 described the endoscopic modified Lothrop. All patients selected for this procedure had failed medical treatment of nasal saline and antiseptic irrigations, topical steroids, and appropriate antibiotics. Nearly all of these patients had also failed standard endoscopic sinus procedures at least once.
Image guidance has improved the precision and safety of this operation. Three of the first 5 procedures performed without image guidance failed. Of the succeeding 99 procedures performed with image guidance, 96% were successful in maintaining open frontal drainage and resolving most symptoms with a prolonged follow-up (mean 42 months).
The endoscopic modified Lothrop is a technically difficult procedure. When performed under the supervision of an experienced endoscopic surgeon with image guidance and modern endoscopic irrigated curved drills, it can be performed safely and effectively when standard endoscopic procedures fail.
(1) Describe new endoscopic balloon technique for dacryocystorhinostomy. (2) Review preliminary outcomes of endoscopic balloon DCR.
This study has 2 parts. The first entails a cadaver study looking at feasibility of applying balloon dilation technology to nasolacrimal duct obstruction. Five cadavers (10 sides) were used to confirm the technique. All 10 nasolacrimal ducts were successfully cannulated and dilated with a 5 × 16 mm balloon via a 70° guide. The second part of the study details our preliminary experience using this technique in patients referred to a tertiary rhinology clinic for nasolacrimal duct obstruction.
A total of 5 patients have enrolled in our prospective study. All patients were successfully cannulated. Follow-up ranges from 1 to 6 months. Resolution or decrease of preoperative epiphora has been noted in all 5 patients.
Transnasal endoscopic balloon dilation of the nasolacrimal duct system may be a possible therapeutic option for the treatment of nasolacrimal duct obstruction. Furthermore, this may be a particularly attractive option for patients who are not candidates for a general anesthetic or cannot be taken off of anticoagulant medication. Further study is warranted.
(1) Describe the anatomy of the incisive foramen. (2) Describe the endoscopic approach to the greater palatine artery. (3) Recognize the importance of the greater palatine artery as a cause of recurrent anterior epistaxis.
Cadaveric and radiographic study of the incisive foramen; illustrative case series. Seventy computed tomography (CT) scans were reviewed, and measurements were made of the incisive foramina’s distance to the anterior nasal spine and subnasale. An endoscopic approach to the incisive foramen was completed in 20 cadavers, and measurements of the distance from the anterior nasal spine to the incisive foramen were documented. We also present an illustrative case series of patients who underwent endoscopic cautery of the greater palatine artery.
Radiographic review of the incisive foramen revealed a mean anterior nasal spine to incisive foramen distance on the right and left of 7.9 and 8.1 mm, respectively. The mean distance from the subnasale to incisive foramen on the right and left were 24.7 and 24.9 mm, respectively. Cadaveric measurements preliminarily correspond to radiographic measurements.
Endoscopic cauterization of the greater palatine artery is a safe and effective method to control recurrent anterior epistaxis. The incisive foramen can be predictively found within 1 cm of the anterior nasal spine. Preoperative evaluation of a CT scan can help aid a surgeon in determining the relative contribution of the greater palatine artery to the anterior septal blood supply, and guide surgical approach to control recurrent anterior epistaxis. Our case series corroborates the above.
Endoscopic medial maxillectomy (EMM) has become the surgical procedure of choice for resection of maxillary sinus inverted papillomas (IPs). Traditionally, IPs pedicled on the anterior and/or lateral walls of the maxillary sinus have required an adjuvant Caldwell-Luc approach due to decreased visualization with transnasal endoscopy in these locations. The objective of the current study is to evaluate outcomes concerning the endoscopic surgical resection of anterolateral maxillary sinus IPs.
A prospective review of patients presenting with maxillary sinus IPs pedicled on the anterior and/or lateral walls was performed. Demographics, pedicle location, operative technique, pathology, complications, recurrence, and postoperative follow-up were evaluated.
Over 6 years, 35 patients (avg. age 56) underwent EMM for maxillary sinus IPs located on the anterolateral maxilla. Most patients (69%) were referred for recurrence after previous attempts at surgical resection. Adequate visualization was obtained following EMM in the majority of patients with use of a 70° endoscope and angled instrumentation. The addition of transseptal surgical access was critical to the removal of IPs in 16 patients. No Caldwell-Luc approaches were required. Pathologic dysplasia was identified in 8 subjects, and 3 had carcinoma. There were no recurrences with a mean disease-free interval of 27 months (6-72 months).
In the present study EMM provided excellent surgical access to anterolateral maxillary sinus IPs. The transseptal approach allowed enhanced visualization to this challenging location previously considered accessible only with external procedures.
Systematically review the exclusive endoscopic treatment of juvenile nasopharyngeal angiofibroma in the literature in order to define the clinical features in terms of staging and the treatment outcomes in terms of bleeding, recurrence, residual tumor, and complications.
Literature was searched by 2 reviewers in online databases including PubMed and Embase with the following inclusion criteria: English or French language and exclusive endoscopic treatment of juvenile nasopharyngeal angiofibroma. Reference sections of identified studies were examined for additional articles. We were only able to perform a meta-analysis on the categorical outcomes using DerSimonian and Laird random effects models.
Ninety-two studies were included with a majority of retrospective studies (54/92; 58.6%). No randomized controlled trials were found. A total of 821 patients were identified. The Radowski classification was the most commonly used (29/92; 31.15%). The mean operative blood loss was 564.21 mL (Min = 20 mL; Max = 1482 mL). It was 414.6 mL (Min = 20 mL; Max = 1000 mL) and 774.2 mL (Min = 228 mL; Max = 1482 mL) respectively in the group with and without embolization. No conclusion could be taken because it was not stratified by tumor stage and because of the absence of randomized controlled trials. The random effect estimate of recurrence was 10% (95% confidence interval, 0.083-0.117). It was 9.3% (95% confidence interval, 0.072-0.115) for complications and 7.7% (95% confidence interval, 0.054-0.101) for residual tumor.
Endoscopic treatment is an evolving modality. It is considered today as the treatment of choice. A new classification system based on the endoscopic approach should be proposed in future studies.
Assess the safety and efficacy of a drug-eluting catheter to be inserted into the ethmoid sinuses during endoscopic sinus surgery to elute triamcinolone in patients with CRSwP (nasosinusal polyposis).
Prospective, randomized, controlled, double-blind, clinical trial using intrapatient control design. The study enrolled 40 patients with CRSwP undergoing endoscopic sinus surgery. In every case, after polypectomy was done to expose the ethmoid bulla, a drug-eluting catheter to elute triamcinolone (0.3 mL) was randomly applied to one nasal fossa, whereas the other was treated by conventional total ethmoidectomy. Outcome measures were visual analogue scales, Rhinosinusitis Disability Index, endoscopy, and olfactometry assessment at baseline, 3, 6, and 12 months. Safety assessments included ocular examinations at baseline and 30 days. All CT imaging was done after more than 12 months of follow-up.
After randomization was performed, unilateral devices were successfully placed in all patients and easily removed after 4 weeks. When comparing both nasal fossae in postoperative endoscopies at 6 and 12 months, the prevalence of edema, adhesions, and recurrent polyposis were statistically similar. Changes from baseline in patient-reported outcomes were statistically relevant in both sides. No clinically important changes in intraocular pressure occurred. CT resolution of pathology was achieved in both sides, improving Lund-Mackay scale, without significant differences.
This trial provides clinical evidence on the safety and efficacy of a drug-eluting catheter for use in patients with CRSwP. It achieves similar results compared to complete ethmoidectomy, without any major complications.
(1) Determine the health-related quality of life (HRQoL) in allergic patients. (2) Identify contributory factors to patient well-being.
Cross-sectional study by multistage sampling from October, 2013, to January, 2014. Kwara state has 16 local government areas with 3 senatorial districts, total land mass of 36,825 km2 with population of 2,591,555. Subjects: 132 consenting adults; 66 had allergic rhinitis (AR) using Score for Allergic Rhinitis (SFAR) instrument, and 66 were age- and sex-matched controls. (χ2 = 0,
The overall Total Symptom Score (TSS) was 3.37 ± 0.9, while male and female allergic patients and control TSS were 3.61 ± 1.0; 3.16 ± 0.8, and 0.98 ± 0.2; 0.95 ± 0.2, respectively. Effects of sex, marital status, senatorial districts, residential area, and duration of symptoms had significant impact on quality of life. The highest correlation between the components of the mRQOL questionnaire existed between eye problems and other symptoms (
AR had appreciable impact on HRQoL of the participants. Sex, marital status, senatorial districts, residential area, and duration of symptoms were major identifiable contributory factors to patient well-being. We recommend prompt diagnosis and management as appropriate.
Participants should be able to: (1) Recognize chronic fungal sinusitis based on clinical examination and radiologic imaging; (2) Analyze the implications of nasal flora contents in suspected chronic fungal sinusitis patients; and (3) Implement surgical and medical treatment of chronic fungal sinusitis.
A retrospective review of the senior author’s patients from 1990 to 2014 was completed in which 50 immunocompetent patients thought to have evidence of fungal sinusitis were identified by the following criteria: Classic “high density” material seen on computed tomography (CT), fungal mycelium seen at surgery/fungal smears, and “Fig Newton” material visualized endoscopically in sinuses. Endoscopic surgery was performed on patients with emphasis to widely open sinuses and trim turbinates, allowing postoperative access to affected areas. Intraoperatively, material from sinus cavities was sent for microbiological and pathological analysis. Postoperatively, patients used saline irrigations to remove debris and potent topical steroids to reduce mucosal reactivity and edema. Antifungal agents were not employed. Regular debridements were carried out in the clinic until healing was complete.
Fungus was present in 29% of cultures/smears, while staphylococcus, pseudomonas, and other organisms were present in 44%. Nasal sinus mucosa returned to normal appearance in the majority of patients with topical treatment. Some patients with a strong allergy history had persistence of hypertrophic mucosa. A pulsed course of oral prednisone generally resolved this.
Wide surgical drainage of affected sinus areas in combination with saline/acetic acid irrigations and topical steroids were successful in nearly all patients without the use of antifungal agents.
The nasal mucosa is the first site that encounters pathogens and forms continuous barriers to various stimuli. Here, we studied the effect of hypoxia on barrier function in normal human nasal epithelial (NHNE) cells. The expression levels of various junction complex proteins were assessed in hypoxia-stimulated NHNE cells and human nasal mucosal tissues.
We performed real-time polymerase chain reaction analysis, western blotting, and immunofluorescence assays to examine differences in the mRNA and protein expression of ZO-1 and E-cadherin in NHNE cells. Moreover, we evaluated the transepithelial resistance (TER) of NHNE cells after hypoxic stimuli to check for changes in permeability. The expression of ZO-1 and E-cadherin was measured in human nasal mucosa samples by western blotting.
Hypoxia time-dependently decreased the expression of ZO-1 and E-cadherin at the gene and protein levels. We also found that hypoxia decreased the TER of NHNE cells, which indicated increased permeability. Human nasal mucosa samples, which are supposed to be hypoxic, showed significantly decreased levels of ZO-1 and E-cadherin expression compared to control.
Our results demonstrate that hypoxic condition in the nasal cavity, which can occur because of natural ostium obstruction, alters the expression of junction complex molecules and increases epithelial permeability in human nasal epithelia. This suggests that hypoxia is a major pathogenic mechanism of rhinosinusitis through its effect of deteriorating barrier function.
Assess the clinical outcome of long-term low-dose oral doxycycline in difficult-to-treat chronic rhinosinusitis with polyps.
We conducted an open label prospective study in a university-based tertiary care center from 2013 to 2014 with 60 patients with difficult-to-treat chronic rhinosinusitis with nasal polyps uncontrolled after 6 or more months of endoscopic sinus surgery. They were divided into 2 groups: 28 patients received nasal steroids plus doxycycline (200 mg on the first day, followed by 100 mg once daily) for 12 weeks while 32 patients received only nasal steroids. The main outcome measure was a meaningful improvement in SNOT-20 (>0.80). Other outcome measures were the SNOT-20, NOSE, and Lund-Kennedy scores. The following parameters were also analyzed: asthma, rhinitis, DREA and blood testing before treatment for IgG, IgA, IgE, IgM, antineutrophil cytoplasmic antibodies, and blood eosinophil count.
There was a statistically significant association among meaningful improvement in SNOT-20 and doxycycline treatment [50.0% (14/28) vs 9.4% (3/32),
These findings suggest that doxycycline may have a beneficial role in chronic rhinosinusits with polyps, particularly in patients without high levels of IgE, asthma, and AERD.
The European Position Paper on Rhinosinusitis and Nasal Polyps (EP3OS) criteria are the most commonly used criteria in the diagnosis of chronic rhinosinusitis (CRS) in Korea. Symptom-based EP3OS criteria are used in epidemiological studies, but its reliability and the best composition of criteria have not been thoroughly examined. Therefore, we aimed to verify its reliability and search the best combination of criteria to diagnose CRS in a large scale.
The 2009 and 2010 data (15,445 people) on Korean National Health & Nutrition Examination Survey symptom questionnaire and nasal endoscopic findings were analyzed. EP3OS criteria composed of major and minor symptoms were used to define symptom-based CRS. Either mucopurulent rhinorrhea from middle meatus or nasal polyp was the definition of endoscopy-based CRS. The correlation between these definitions of CRS and the relative importance of symptoms, and the best combination of symptoms were analyzed.
The symptom-based definition of CRS showed statistically significant correlation with the endoscopy-based definition of CRS (Pearson
Because the symptom-based definition didn’t show strong correlation with the endoscopy-based definition, the combination of both definitions is essential in the diagnosis of CRS. If symptom-based definition is used, one of major symptoms + hyposmia or anosmia is the most reliable criterion in the diagnosis of CRS.
Spontaneous cerebrospinal fluid (CSF) leaks typically present in patients with undiagnosed idiopathic intracranial hypertension (IIH) secondary to pressure erosion of the skull base. Despite elevated intracranial pressure (ICP) on lumbar puncture or ventriculostomy, patients with spontaneous CSF leaks rarely complain of visual disturbances. The objective of this study is to correlate the presence of preoperative papilledema with opening ICP in patients undergoing endoscopic repair of spontaneous CSF leaks.
Prospective evaluation of patients with spontaneous CSF leaks was performed over a 1-year period (December 2012 to December 2013). Fundoscopic examination for papilledema was completed preoperatively and CSF pressure was measured by lumbar puncture or ventriculostomy intraoperatively. Data regarding demographics, nature of presentation, and body mass index (BMI) were also recorded and compared to a control cohort of IIH patients with papilledema.
Sixteen patients (avg. age 52 years) were evaluated. Obesity was present in 94% of individuals (avg. BMI 43.5; range, 27-65). Papilledema was absent preoperatively in all subjects. Opening pressures via lumbar puncture/ventriculostomy were 27 ± 7.7 cmH20. Following 6 hours of clamping, measurements significantly increased to 36 ± 9.7 cmH20 (
Subjects with spontaneous CSF leaks had post-clamping average ICP identical to controls with IIH and papilledema. Such evidence suggests that a CSF leak in this patient population provides sufficient pressure diversion to avoid the development of papilledema.
Determine the relationship between a loop-type configuration of the third portion of maxillary artery and its position according to the inferior belly of the lateral pterygoid muscle.
A descriptive transversal study in preserved cadaver head specimens, conducted between August and December of 2013, on a total of 23 hemi-heads of Latin American origin, in which the second and third portions of the maxillary artery were dissected through an endoscopic transmaxillary approach to the pterygopalatine and infratemporal fossa.
A total of 23 maxillary arteries were dissected, of which 7 (30.4%) were found to be superficial to the inferior belly of the lateral pterygoid muscle (LPMib) and 16 (69.6%) were found to lie deep. A total of 16 arteries (69.5%) were found on a loop-type configuration, and 7 (30.5%) were found on an ascending configuration. The loop type was found deep to the LPMib in 13 (81.3%) of the cases and superficial in 3 (18.8%) of them. The results were analyzed with Fisher’s exact test with a
This study shows a tendency in the Latin American population to have maxillary arteries deep to the LPMib in loop configuration, which emphasizes the need to stay close to the pterigomaxillary fissure during surgical dissection when aiming to find the main trunk of this vessel in its transition point between its second and third portions. Although the results are promising, the results need to be confirmed in a larger sample.
The primary aim of the study was to evaluate intraoperative management of the orbit during endoscopic resection of benign and malignant sinonasal tumors.
Retrospective chart review and prospective imaging assessment was performed of 215 cases managed at a tertiary care referral center between July 2009 and December 2012.
A total of 41 patients met predetermined criteria for inclusion. Squamous cell carcinoma (17.1%) and inverted papilloma (31.7%) were the most common malignant and benign pathologies, respectively. Preoperative computed tomography (CT) and magnetic resonance imaging (MRI) most commonly demonstrated lamina papyracea erosion (78.1%), followed by extension into the periorbita (43.9%), lacrimal system (24.4%), orbit (14.6%), and orbital apex (7.3%). Procedures performed to address orbital involvement included endoscopic resection of lamina papyracea (85.3%), dacryocystorhinostomy (DCR) (26.8%), optic nerve decompression (7.3%), and orbital exenteration (4.8%). Ophthalmologic involvement was required in 31.7% of cases; anterior orbitotomy (26.8%) and open DCR (17.1%) were the most common adjunct open procedures. Orbital complications most commonly included epiphora (7.3%) and diplopia (5.1%), with no cases of change in visual acuity or orbital hematoma. CT reliably predicted invasion of the lamina papyracea and lacrimal system (
CT and MR imaging provide complementary information for assessment of tumor extension to the orbit. This typically requires endoscopic and adjunct open approaches for effective tumor extirpation and can be achieved safely with low rate of complications.
Long-term follow-up of 1045 patients with chronic rhinosinusitis with nasal polyposis (CRSwNPs) in the national Sinonasal Audit demonstrated that at 5 years 20.6% of patients had undergone revision surgery. The aim of this study was to see if the Chronic Rhinosinusitis Epidemiology Study (CRES) data reflected a continued burden of revision surgery in patients with CRSwNPs.
A prospective questionnaire-based study at 30 sites around the UK of patients with CRS presenting to secondary care between October 2007 and September 2013. This paper presents a specific analysis of patients with CRS who reported undergoing sinus surgery.
A total of 651 patients with CRSwNPs, 553 with CRSsNPs, and 45 with AFRS were included in the CRES. 365 (57%) of patients with CRSwNPs/AFRS reported undergoing endoscopic nasal polypectomy (ENP) in which 175 (25% or 48% of surgical cases) reported having received more than one ENP. The mean number of ENPs per patient in the revision group was 3.3 with a range of 2 to 30. Only 27.9% of patients reported concurrent endoscopic sinus surgery (n = 102). For comparison, patients with CRSsNPs reported ESS in 13% of cases with only 17% of those surgical cases reporting multiple procedures (chi-squared
This study demonstrated a significantly higher burden of both primary and revision surgery to the health care system for patients with CRSwNPs. Extrapolation of these findings to the HES data for 2011 and 2012 would suggest a bill of approximately £5.3 million per year spent on revision surgery.
Ideal mucosal incision followed by adequate osteotomy is the key to successful endonasal endoscopic dacryocystorhinostomy. Hence anatomical correlation of intranasal lateral nasal wall landmarks to lacrimal sac and duct was done with secondary computed tomography (CT) correlation.
A descriptive study of 10 adult cadaver head sections fixed with 10% formaldehyde solution was done in the anatomy and radiology departments of a tertiary hospital from 2010 to 2011. Following CT scan, these were sagittally sectioned to 10 right and left specimens. Measurement of anatomical landmarks in CT and dissection were taken by metric ruler and digital calipers respectively. With application of paired t test, mean was calculated.
Maxillary line was clearly identified in 75% of cadavers, the majority overlapping the lacrimal sac. In all cadavers superior end of lacrimal sac was above the axilla, distance between them being 8.88 mm. Length of lacrimal sac was 11.72 mm. These showed positive correlation with CT scan. Distance between anterior edge of lacrimal sac and axilla was 10.58 mm. Genu was at or posterior to nasolacrimal duct in the majority, the length of duct being 10.27 mm. This showed positive correlation with CT.
Important endonasal landmarks are of middle turbinate—axilla and genu (bony), and maxillary line (mucosal). Mucosal Incision, 9 to 10 mm above axilla, anterior to maxillary line and genu, 10 to 11mm long to just above level of genu, is sufficient to expose lacrimal sac up to its inferior limit. Preoperative CT scan can be reserved for revision or post-traumatic nasolacrimal sac pathology.
Chronic rhinosinusitis with nasal polyps is a common disorder that requires multiple methods to monitor disease burden. There is no validated questionnaire to monitor nasal polyp patient symptoms over time. We describe a novel 10-item questionnaire (Sinonasogram) which is currently used in clinical practice to evaluate current and 4-week symptoms that are common to patients with chronic rhinosinusitis.
Twenty-five consecutive patients with nasal polyps seen in a university setting were included in this retrospective review. Patients were included if they had multiple visits to clinic and filled out the Sinonasogram questionnaire at each visit. Nasal polyp score was graded on a (0-5) scale. Statistical analysis was performed to determine correlation between changes in current, 4-week, and total Sinonasogram score and changes in nasal polyp score and to determine internal consistency.
Twenty-five patients were included for analysis with a total of 81 clinic visits. Changes in total and current Sinonasogram scores were significantly correlated with changes in nasal polyp scores (
The Sinonasogram is a valid tool for monitoring nasal polyp symptoms and can predict changes in nasal polyp size. Symptoms that were found to be most associated with nasal polyps were nasal obstruction, hyposmia, and anterior rhinorrhea.
Study the effects of zinc and steroid in the treatment of traumatic anosmia.
Patients with a clear history of complete loss of smell after head injury were collected from January 2010 to May 2013. All patients received phenyl ethyl alcohol threshold test, and those whose thresholds were –1 were included in this study. They were randomly divided into 4 groups. Patients in group 1 were treated with zinc sulfate (15mg tid) for a month and high dose prednisolone (1 mg/kg per day) with tapering for 2 weeks. Those in group 2 only took zinc, and those in group 3 only took prednisolone. Patients in group 4 did not take any medicine. All patients were followed up by phenyl ethyl alcohol threshold test to find whether their olfactory function improved and had magnetic resonance imaging to measure the volume of olfactory bulbs.
There were 145 patients completing the study. Thirty-nine belonged to group 1, 34 to group 2, 35 to group 3, and 37 to group 4. Olfactory function improved in 11 patients (28.2%) who took prednisolone and zinc, in 9 (25.7%) who took zinc, in 4 (11.8%) who took prednisolone, and in 1 (2.7%) who did not take any medicine. The olfactory improvement rates of groups 1 and 2 are significantly higher than that of group 4. The volume of olfactory bulbs is not significantly different between those with and without improved olfactory function.
Our results show that zinc has good effect in treating traumatic anosmia.
Respiratory secretion glucose concentration is tightly regulated and contributes to airway innate immunity. Thus, we set out to quantify nasal mucus glucose concentration in chronic rhinosinusitis (CRS) patients and correlate these values to CRS symptoms.
Prospective, single-center study measuring nasal mucus glucose concentration in patients diagnosed with chronic rhinosinusitis and age/race matched controls from July 1, 2013, to January 1, 2014. Enrollment included subjects >18 years of age evaluated in academic otolaryngology practice. Subjects completed questionnaires including extensive history of medical and surgical therapies as well as CRS-specific quality of life measurements (SNOT-22). Subjects underwent nasal secretion sampling with sterilized Pope ear wicks. The nasal glucose concentrations of controls and subjects were analyzed with multivariate analysis to assess for confounding variables including systemic and topical glucocorticoid treatment.
Ninety-five patients enrolled, and 3 patients were excluded because of history of sinonasal radiation. A statistically significant difference was measured between mean nasal glucose secretions of control subjects, 11.1 mg/dL (±1.0 mg/dL), compared to patients diagnosed with CRS, 18.4 mg/dL (±1.6 mg/dL) (
CRS patients demonstrate elevated nasal glucose concentrations independent of therapeutic glucocorticoid use. However, nasal mucus glucose concentrations do not appear to correlate to CRS symptoms. The role of nasal mucus glucose concentrations in CRS pathophysiology has yet to be determined.
Identify the prognosis for patients with post-traumatic olfactory dysfunction.
From 2007 to 2013, patients with posttraumatic olfactory dysfunction were enrolled. The threshold, discrimination, and identification (TDI) score of Sniffin’ Sticks test was ≤15 for anosmia, ≥30 for normosmia, and between these values for hyposmia. Olfactory improvement/decline was defined as an increase/decrease in TDI score ≥ 6 points. The cumulative incidence rates of olfactory improvement and decline were calculated using the Kaplan-Meier method. Variables with a potential impact on olfactory changes were entered into Cox regression analysis. The correlation between the TDI scores of the first and last visit was evaluated.
We included 80 patients with an average 9.4-month follow-up period (range, 1-52 months). The 12-month cumulative rates of olfactory improvement and decline were 8.4% and 11.8%, respectively. Anosmia, hyposmia, and normosmia were noted in 71.2%, 27.5%, and 1.2% of the patients at the first visit and 72.5%, 23.8%, and 3.8% at the last visit (Fisher’s exact,
Posttraumatic olfactory dysfunction was associated with a lower risk of decline in olfaction and a lower likelihood of improvement. Although most patients maintained a stable disease status, anosmia in the majority of patients may reflect a poor prognosis in olfactory recovery for patients with head trauma.
Computed tomography (CT) measurements were used to investigate the feasibility of performing vascularized nasoseptal flap reconstruction of sellar defects in children.
Ten CT scans from children of each year of age from birth to 18 were obtained for 190 total subjects. Patients with incomplete pneumatization were excluded from analysis. Measurements of nasoseptal flap and sellar defect length were obtained for each subject using OSIRIX radiology software. Reconstruction was presumed feasible if the ratio of nasoseptal flap length to associated sellar defect length was greater than 1.
Of the 190 CT studies, 125 displayed complete pneumatization. Of these, 120 (96%) displayed a ratio of nasoseptal flap length to sellar defect length greater than 1, suggesting feasibility of flap reconstruction. Mean ratio of nasoseptal flap length to sellar defect length for all subjects was 1.47 (SD = 0.33) with 95% CI [1.41, 1.53]. Only 5 patients (4%) had inadequate nasoseptal flaps; mean age for these patients was 14.8 years (SD = 2.9), which is older than mean age of 11.6 years (SD = 4) for subjects with adequate measurements. The mean age difference did not meet significance with
Flap length is not a limiting factor in nasoseptal flap reconstruction of sellar defects in children. Younger patients have higher ratios of nasoseptal flap length to sellar defect length than older patients.
Prosthetics—including buttons and other obturators serve as an option for nasoseptal perforation repair in patients who have active systemic disease, are poor surgical candidates, or wish to avoid surgery. By systematically reviewing the literature on prosthetics for nasoseptal perforation repair, the objective of the present study is to critically appraise previous studies, provide evidence-based guidelines for nasoseptal prosthetic use, and identify areas for further investigation.
The Cochrane Controlled Trials Register, EMBASE, PubMed, and Web of Science were queried for relevant articles published from 1965 to 2013. Articles were selected for inclusion if they presented primary data for human nasoseptal perforation treatment utilizing prosthetic materials. The reference lists of included articles were searched for additional studies. Each included article’s level of evidence was identified and grades of recommendation were assigned.
The search yielded 4756 abstracts for review, with 23 case series and 5 case reports meeting inclusion criteria. A total of 706 cases of prosthetic nasoseptal perforation repair were identified, with a case series median n = 20. All articles provided level 4 evidence, with an overall conclusion grade of C for improvement in nasoseptal perforation symptoms, prosthetic in situ rate, and complication rate.
The literature provides considerable level 4 evidence for the efficacy and safety of prosthetics for nasoseptal perforation repair with success rates of 33% to 100% and minimal complications: only 1 fungal infection and 9 unspecified infections in 706 cases. The disease- and prosthetic-specific factors influencing symptom improvement and prosthetic tolerance require additional study for further elucidation.
There is currently conflicting level 1 evidence in the use of long-term antibiotics for chronic rhinosinusitis. The primary aim of this study was to look at recruitment and retention of patients in preparation for a formal trial. The aim of this paper is to describe the preliminary outcomes in terms of symptomatic relief in patients with CRSsNP.
Adult patients fulfilling the EPOS criteria for CRSsNPs with no prior surgery were recruited in 6 UK centers during 2013. Participants received a 12-week course of clarithromycin 250 mg alongside topical mometasone and nasal douching, all twice daily. Follow-up was at 3 months and 6 months. For the purpose of this analysis, the Sinonasal Outcome Test (SNOT-22) score was recorded at baseline and both follow-up assessments.
Preliminary data from 29 patients at 3 months and 24 patients at 6 months showed significant symptomatic improvement in mean SNOT-22 scores on paired
While the results here do not have the power of the full randomized controlled trial, the findings suggest that long-term macrolides have the potential to achieve significant symptomatic reduction in approximately 50% of patients with CRSsNPs.
Allergic fungal rhinosinusitis (AFRS) may present with significant bone erosion of the orbital walls or cranial base. Although proptosis is fairly common, cranial neuropathies are rarely reported. The objectives of this study are to describe strategies for AFRS-induced neuropathies and evaluate ophthalmologic outcomes following endoscopic sinus surgery.
A retrospective review of patients treated from January 2009 to December 2012 for AFRS-induced cranial neuropathies was performed. Data regarding patient demographics, preoperative imaging, ophthalmologic symptoms, surgical intervention, histopathologic findings, and postoperative sinonasal and ophthalmologic outcomes were recorded.
Eight patients (average age 38 years; range, 18-84 years) with AFRS presented with optic neuropathy or abducens nerve palsy. Subjects presented with unilateral visual loss secondary to optic nerve compression (n = 4), diplopia from unilateral (n = 2) or bilateral (n = 1) abducens nerve palsy, and bitemporal hemianopsia secondary to optic chiasm compression (n = 1). On average, the duration of ocular symptoms was 17 days (range, 2-60 days). All patients underwent endoscopic surgical decompression of the sinuses and oral steroid therapy. Two individuals had an additional optic nerve decompression at the time of surgery. Six patients had complete return of nerve function, while 2 had partial recovery at an average of 5 weeks following surgery (range, 2-12 weeks).
Bone erosion of the sphenoid sinus walls by AFRS can lead to compression of surrounding neural structures producing cranial neuropathies. Identification of these symptoms and prompt surgical decompression and removal of disease along with aggressive medical therapy provided excellent outcomes in the current series of patients.
(1) Assess secondary nasoseptal flaps (NSF) as a viable reconstructive option. (2) Evaluate postoperative vascularity of secondary NSFs. (3) Compare cerebrospinal fluid (CSF) leaks and complication rates of secondary NSFs to primary NSFs.
This is a retrospective review of patients from 2009 to 2013 undergoing transsellar approaches for skull base tumors at the University of Pittsburgh Medical Center. In cases where the necessity of a vascularized reconstructive flap was made evident only after tumor resection, the NSF was raised after the tumor had been resected and/or CSF leak had developed (secondary NSF). Outcome measures include postoperative magnetic resonance imaging (MRI) findings, CSF leak rates, and complication rates.
Transsellar approaches were performed in 436 patients during this timeframe. Primary NSFs were used to reconstruct 178 patients while 32 patients had secondary NSFs. Postoperative MRI scans were available in 29 of 32 secondary NSF patients; all maintained vascularity on examination of T1 post-contrast images (mean time to MRI 4.9 months). There was no significant difference in CSF leak rate between primary NSFs (3.4%) and secondary NSFs (3.1%) (
Secondary NSFs are a viable reconstructive option for sellar skull base defects. They maintain vascularity as evidenced on postoperative MRI imaging and compare favorably to primary NSFs in regard to CSF leak rates and complication rates.
(1) Evaluate the histopathological and immunohistochemical characteristics of different types of nasal polyps. (2) Quantify the expression of IL-5 and IL-8 in 2 different histotypes of nasal polyps in order to evaluate the role of these cytokines in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP) .
This retrospective study was conducted on 44 specimens collected from nasal cavities of 44 patients with nasal polyposis who underwent functional endoscopic sinus surgery at the ENT University Unit of the A. Fiorini Hospital, Sapienza University of Rome, from January 2009 to January 2011. The specimens were analyzed at the histopathology unit of the university and divided into 2 groups according to their dominant histological features: Group A (polypoid mucosa and eosinophilia, 34 subjects) and Group B (polypoid mucosa associated with glandular hyperplasia, 10 subjects). Expression of IL-5 and IL-8 were analyzed on the specimens using immunohistochemical techniques. The same tests were run on nasal mucosa specimens drawn from 10 patients without sinusitis (control group).
IL-5 expression was significantly more expressed in Group A than in Group B (
The outcomes of this preliminary study suggest that IL-8 may play a role in the pathogenesis of both histological subtypes of nasal polyps, whereas IL-5 predominates in the eosinophilic subtype.
Investigate the frequency of pediatric middle turbinate pneumatization and present its possible effect on septal deviation.
Computed tomography (CT) scans of 152 children (younger than 16 years old) were analyzed for the presence of middle turbinate pneumatization and nasal septal deviation.
The incidences of lamellar, bulbous, and extensive concha bullosa were 29.6%, 14.5%, and 7.2%, respectively. The data revealed that 53 patients (67.9%) with concha bullosa also had septal deviation as opposed to 50% (37 out of 74 cases) frequency of septal deviation in patients without concha bullosa. Among the 37 patients with right side concha bullosa, 59.5% had a deviated septum to their left side while 21.6% had a deviation to the right side. Out of those patients with concha bullosa on the left side (38 cases), 44.7% had a right side septal deviation and 13.2% had a left-side septal deviation that revealed a significant relationship between the position of concha bullosa and the side where the septum deviated (
A possible relationship was found between middle turbinate pneumatization and the mechanism of development of septal deviation in children.
(1) Compare intramural bipolar electrocautery and radiofrequency coblation in the treatment of inferior turbinate hypertrophy with regard to objective and subjective improvement in nasal obstruction, rate and type of complications, experience during the procedure, and rate of recovery. (2) Describe 2 minimally invasive techniques in the management of turbinate hypertrophy with a comprehensive literature review of the efficacy of these methods.
A prospective, randomized, single blinded study from 2008 to 2010 at a single tertiary medical center. Adult patients with inferior turbinate hypertrophy refractory to medical management were randomized to 2 groups based on which nostril they felt to be more obstructed. Patients were then treated with radiofrequency coblation in one nostril and intramural bipolar cautery in the other. Subjective and objective data, including use of a visual analog scale (VAS) for subjective outcomes, acoustic rhinometry, and nasal endoscopy, were then obtained from each patient comparing the 2 techniques.
Radiofrequency coblation was significantly less painful than intramural bipolar cautery for the early postoperative period (
Radiofrequency coblation seems to offer an equivalent alternative to bipolar electrocautery for the treatment of inferior turbinate hypertrophy with less discomfort during the procedure and early postoperative period.
(1) Investigate the ability of a sinus-specific health-related quality of life questionnaire (HRQoL) to distinguish clinically significant chronic rhinosinusitis (CRS) among adults with cystic fibrosis (CF). (2) Determine an appropriate cutoff score on the Sinonasal Outcomes Test-22 (SNOT-22) with sufficient test sensitivity and specificity, to assist caregivers in identifying adults with CF who may warrant specialist referral and treatment.
Participants were enrolled at an adult-specific CF clinic in a tertiary academic hospital in Vancouver, Canada. Subjects completed the SNOT-22 followed by endoscopic assessment by otolaryngologists. The Canadian Clinical Practice Guidelines for Chronic Rhinosinusitis were used to confirm diagnosis of CRS.
To date, 52 of 80 individuals with a confirmed diagnosis of CF have participated in this study. Thirty-nine (75.0%) individuals were identified with CRS, 12 (30.8%) of whom presented with nasal polyposis. Aggregate SNOT-22 scores were significantly higher among individuals with CRS compared to non-CRS counterparts (39.4 ± 20.0 vs 22.7 ± 8.7,
The SNOT-22 significantly discriminates between CF adults with and CF adults without CRS. Using rhinological symptom scores increases the likelihood of detecting true CRS cases. The use of this questionnaire may assist specialists in identifying individuals who have clinically significant CRS, warranting specialist referral and treatment.
Evaluate the safety and efficacy of a novel, self-crosslinked hyaluronic acid (HA) hydrogel (PureRegen Gel Sinus) compared with carboxymethylcellulose (CMC) viscous foam (Stammberger SinuFoam) in promoting healing when applied following ethmoidectomy.
Prospective, randomized, controlled, double-blinded clinical trial, with 4 surgeons operating in 2 community hospitals. Thirty patients with bilateral chronic rhinosinusitis underwent bilateral ethmoidectomy. Intraoperatively, each patient received 2 mL of HA hydrogel in one ethmoid cavity, and 2 mL of CMC contralaterally. The material applied within each ethmoid cavity was randomly assigned before surgery. A fifth independent surgeon, blinded to the material used to treat each ethmoid cavity, evaluated postoperative endoscopic video at 1 and 2 weeks for edema, crusting, and mucopurulence and at 6 and 12 weeks for re-mucosalization and scarring/synechiae. SinoNasal Outcome Test (SNOT-20) data were collected preoperatively and at each postoperative visit. A small sample of the cohort underwent endoscopic mucosal biopsy for histologic analysis.
Twenty-nine of 30 patients completed the protocol. The difference in edema, crusting, and mucopurulence at 1 and 2 weeks was not statistically significant; however, at 6 and 12 weeks, the HA hydrogel showed statistically significant reduction in synechiae formation (
Self-crosslinked hyaluronic acid hydrogel provides superior wound healing to carboxymethylcellulose after ethmoidectomy.
(1) Compare the incidence of radiographic sinus disease before and after laryngectomy by retrospective analysis of preoperative and postoperative computed tomography (CT) scans. (2) Analyze the change in pre-existing radiographic sinus disease via a subset analysis.
A single-institution retrospective chart review was conducted. Patients who received a total laryngectomy or total laryngopharyngectomy between 2002 and 2012 with preoperative and postoperative CT scans were included. The Lund-Mackay (LM) Scores for each sinus as well as the total LM score were recorded for both scans. The assessment of differences in these scores is based on McNemar’s statistic for each sinus and on a paired
Surgical removal of the larynx creates an anatomical disconnect between the sinonasal cavity and distal respiratory tract. Normal nasal airflow is disrupted, resulting in alterations to the nasal mucosa, mucociliary clearance, and nasal flora. While the incidence of sinonasal disease in patients undergoing total laryngectomy has been studied via subjective scoring methods, this study is the first to evaluate radiographic sinusitis via an objective measure by comparing Lund-Mackay scores before and after total laryngectomy. There were no significant differences in the LM scores between preoperative and postoperative scans within each sinus (
In patients undergoing total laryngectomy, disruption in nasal airflow has been correlated with altered sino-nasal physiology and decreased subjective symptoms. However, our study shows no significant change in radiographic evidence of sinonasal disease after laryngectomy.
Evaluate the efficacy and cost-effectiveness of empiric treatment of sinus headaches/migraines initiated by an otolaryngologist versus referral to a neurologist for treatment.
Retrospective chart review from 1998 to 2013 of patients with ICD-9 codes for headache or atypical facial pain at an academic medical center. Comparison of cost of workup and treatment initiated by an otolaryngologist was compared with that of patients referred to neurology. Length of delay in treatment was also calculated for patients referred to neurology.
Of 797 patients reviewed, 57 patients were primarily treated by otolaryngology, and 104 patients were referred to neurology for treatment. Success of patients treated by otolaryngology was 78.9% versus 81.8% for neurology-treated patients (
Recognition of sinus headaches as migraines by the otolaryngologist and initiation of treatment allows for earlier improvement of symptoms, improved quality of life, and decreased health care costs, with equal success rates to that of patients treated by neurology.
(1) Characterize baseline sinonasal symptoms for hereditary hemorrhagic telangiectasia (HHT) patients. (2) Analyze changes in sinonasal symptoms before and after laser surgical treatment for HHT.
Retrospective chart review of sinonasal outcome test-22 (SNOT-22) scores before and after one or more laser surgical treatments for HHT-related epistaxis between January 1, 2010, and December 31, 2013, in a tertiary academic medical center with an HHT Foundation-approved Center of Excellence. All HHT patients who had undergone one or more laser surgical treatments by 1 of 2 otolaryngologists were included in the analysis. Preoperative and all subsequent postoperative SNOT-22 scores were compared using unpaired
A total of 21 consecutive HHT patients underwent laser surgery for recurrent epistaxis. Compared with preoperative scores, patients reported significantly improved (
HHT patients experienced a short-term improvement in sinonasal symptoms, especially those producing social and emotional consequences, following laser surgery for HHT-related epistaxis. This study once again underscores the important role of the otolaryngologist in managing sinonasal manifestations of HHT.
Evaluate the most sensitive symptom that predicts recurrence of nasal polyposis.
In this prospective study, we evaluated 62 patients with diffuse nasal polyposis. All patients underwent functional endoscopic sinus surgery. Sino-Nasal Outcome Test (SNOT-22) was answered by patients at preoperative visit and 1, 3, 6, 12, and 24 months after surgery. All of the patients were on maintenance therapy with nasal corticosteroid and saline irrigation postoperatively for 6 months. Patients were followed up with serial endoscopic examination, and computed tomography (CT) scan was performed if indicated.
All 62 patients (37 male, 25 female) completed the study. The mean age was 41.24 ± 12.47 years. Allergic rhinitis and asthma existed in 45% and 43.5% of cases respectively. Seven patients (11.3%) underwent revision surgery during the 2-year follow-up period. Fifty-two patients had a smell problem preoperatively, but 98.1% of them regained satisfactory olfaction after the surgery. The severity of symptoms gradually increased in patients with recurrence of polyposis but at a different point of time (
The most sensitive symptom for the recurrence of nasal polyposis is decrease in sense of smell. Recurrence of nasal obstruction was noticed in the late stage of relapse when frank polyposis formation was established.
Search for correlations between spontaneous cerebrospinal fluid rhinorrhea (SCSFR) and overweight/obesity and imaging data.
Retrospective study of patients with SCSFR operated in a tertiary center (1993-2013). A 2-sided test was used for statistics.
There were 17 patients with SCSFR: 9 females/8 males; mean age 45 years (range, 3-84 years). Abnormalities on computed tomography (CT) were: bone defect (12), sinus opacity (11). Abnormalities on magnetic resonance imaging (MRI): continuity with meninges (7), meningocele (6), empty sella (6), dilation of optic nerve sheath (6), pneumocephalus (1). Patients underwent endoscopic closure of osteo-meningeal defect with fat. Primary success rate was 13 out of 17 (76.5%). Regarding body mass index (BMI), 12 patients out of 17 (70.6%) were overweight (BMI ≥25) versus 32% in the French general population (
We found statistically significant correlations between SCSFR and overweight individuals, increased pneumatization of sinuses, empty sella, and dilation of optic nerve sheath, but not with obesity. This could be due to the small number of patients in this study and a weak statistical power for obesity. The 2-sided test is ideal for small samples of patients, but a greater number is needed in the future to confirm these preliminary results.
A majority of anterior skull base meningoceles are often managed via the endoscopic endonasal approach (EEA) for the excision and repair of the cerebrospinal fluid (CSF) leak, in addition to the reconstruction of the skull base defect. The aim of the study was evaluation of an institutional case series to identify specific risks and strategies for successful management of anterior skull base meningoceles.
Case series review of all surgical cases involving repair of any anterior skull base meningocele spanning 3 years.
A total of 18 patients were managed surgically for repair of meningocele with or without CSF rhinorrhea. All patients had postoperative follow-up to one year. EEA was used in 17 patients, and one had a combined transcranial with endoscopic approach. Four patients had meningoceles with a larger than 1.0-cm bony skull base defect. Large spontaneous meningoceles along the ethmoid were likely to include cerebrovascular structures within their intranasal component. Nasal airway obstruction was the initial presenting symptom in all large spontaneous ethmoid meningoceles, rather than CSF rhinorrhea (present in all large traumatic ones).
The endoscopic technique is a safe and effective approach to repair of anterior skull base defects involving both ethmoid and sphenoid regions. Successful repair of lateral sphenoid wall defects depends on gaining sufficient access via incorporating extended approaches, such as trans-pterygopalatine approach. Preoperative angiography may be warranted, especially in spontaneously appearing anterior skull base meningoceles with a bony defect larger than 1.0 cm.
This analysis uses data from the Chronic Rhinosinusitis Epidemiology Study (CRES). The overarching aim of CRES is to determine factors which influence the onset and severity of chronic rhinosinusitis (CRS). Sino-Nasal Outcome Test (SNOT-22) is a widely used score for nasal symptoms in many ENT clinics internationally, although there are few data characterizing SNOT-22 scores for a normal population. The aim of this analysis is to establish a dataset of normal values for SNOT-22 in a British population.
Study-specific questionnaires including demographic and socioeconomic factors and past medical history as well as SNOT-22 and SF-36 were distributed to patients with CRS attending ENT clinics and to a control population across several centers in the United Kingdom. This analysis considered just the control population. Controls had no self-reported nasal problems in the past, no chronic conditions undergoing active treatment, and no hospital admissions in the preceding 12 months.
A total of 1529 participants were recruited; 57 with AFRS (allergic fungal rhinosinusitis), 659 CRSwNP (with nasal polyps), 577 CRSsNP (without nasal polyps), and 236 controls. Age range was 18 to 98 years. Two hundred thirteen controls included sufficient information to calculate SNOT-22 score. Score range was 0 to 85; median 9, mean 13.4.
SNOT-22 is an important tool for measuring the impact of nasal symptoms and evaluating effectiveness of treatments. Data for a large population without nasal problems will be invaluable in both clinical and academic settings. Further analysis will characterize SNOT scores for different types of CRS and subgroup analysis of different elements of SNOT-22.
(1) Demonstrate the incidence of human papillomavirus (HPV) transcriptional activity in inverted Schneiderian papilloma (IP). (2) Evaluate the role of HPV in the pathogenesis of IP and its rare progression to malignancy. (3) Support the consideration of RNAscope in diagnosis and management of IP.
Retrospective clinical and histopathologic review of 20 cases of IP who underwent surgical excision at a tertiary referral center between 1995 and 2013. Surgical pathology archival material was re-examined histopathologically using H&E slides. Formalin-fixed paraffin-embedded material from each case was further evaluated using immunohistochemical staining for p16 as well as in situ hybridization (ISH) for HPV E6/E7 mRNA (RNAscope).
Patients were 40% female with average age 53.7 years (range, 23-82 years). Three had evidence of malignancy at the time of excision, and 5 demonstrated recurrence of IP. Average follow-up was 48 months (range, 0-200 months), and one patient died from squamous cell carcinoma (SCC) arising from the IP. HPV transcriptional activity noted by RNAscope within specimens is reported.
These data serve to aid in clarification of conflicting prior research attempting to establish a connection between the presence of HPV and development of IP. By demonstrating transcriptional activity of HPV in IP, this connection is rendered more definitive. Further studies are necessary to elucidate the mechanism by which this process occurs, and what, if any, impact HPV status has on progression from IP to SCC.
Determine the long-term outcome of patients suffering from obstructive sleep apnea syndrome (OSAS) treated by ablation-assisted uvulapalatopharyngoplasty.
Seventy-five subjects were included between 2005 and 2007. All patients suffered from moderate or severe OSAS. They were treated by radiofrequency volumetric tissue reduction (RFVTR) of the palatopharyngeal abnormal tissues (including tonsillar RFVTR or tonsillectomy), the advance of palatopharyngeal arch after the dissection of palatopharyngeal vault, and the inferior one-third of the palatine velum interspace. Polysomno-graphy (PSG), snoring (assessed on a 10cm visual analog scale [VAS]), marital status, and presence of cardiovascular risk factors or pathologies were evaluated by postal questionnaire.
Mean follow-up time was 5.3 ± 1.3 years. Mean snoring intensity decreased significantly in the immediate postoperative period (8.1 ± 2.9 to 3.5 ± 2.2 cm on VAS). Over the longer term, however, we observed a slight increase in snoring intensity (3.7 ± 2.9 cm) (
Ablation-assisted uvulapalatopharyngoplasty is highly effective in the treatment of OSAS. Expected scar formation, enlarged nasopharyngeal and oropharyngeal cavity, reduction of the uvula and lateral pharyngeal bands may contribute to these good success rates.
Orbital approaches provide significant trajectory to the skull base and are used with different designed pathways. The aim of this study is to investigate the feasibility of a combined endoscopic transorbital and transnasal approach to the anterior and middle cranial fossa.
Cadaveric dissection of 5 silicon-injected heads. A total of 10 bilateral transorbital approaches and 5 extended endonasal approaches were performed. Identification of the surgical landmarks, main anatomical structures, feasibility of combined approach, and reconstruction of the superior orbital defect were examined. Rod lens endoscope (with 0° and 45° lenses) and endoscopic instruments were used to complete the dissection.
The transorbital approach showed great versatility and provided the surgeon a direct route to the anterior and middle cranial fossa. Anterior/posterior ethmoid arteries, optic nerve, and superior orbital fissure were the landmarks for the superior orbital wall craniectomy. Transorbital avascular plane showed no conflict with major nerves or vessels. Large exposure area from crista galli to the third ventricle was demonstrated with significant control of different neurovascular structures. The combined transorbital transnasal approach provided considerable value in form of extent of the exposure and the free hand movement of the 2 surgeons.
Combined transorbital transnasal approach demonstrates better visualization and control of the ventral skull base and can overcome the current surgical limits of a single approach. Combination of these 2 minimally invasive approaches should reduce the overall morbidity. Clinical trials are needed to evaluate the virtual applications of this approach.
Examine the efficacy of minimally invasive hyoid myotomy and mandibular suspension with adjustable tensioning for hypopharyngeal obstruction in conjunction with uvulopalatopharyngoplasty in the surgical treatment of obstructive sleep apnea.
Retrospective chart review in a private practice. Twenty consecutive patients with multilevel obstructive sleep apnea over a 12-month period were included. Patients underwent hyoid myotomy and suspension and uvulopalatopharyngoplasty with or without tonsillectomy either staged or performed at the same time for those patients who had not undergone uvulopalatopharyngoplasty previously. The hyoid was suspended to the posterior surface of the mandible using the Siesta Encore system and desired tension set through a single small submental incision. Patients underwent clinical examination and sleep study prior to surgery and approximately 3 months postoperatively. The primary outcome was a successful surgical result, defined as respiratory distress index lower than 20, and 50% or greater decline in respiratory distress index, and no oxygen desaturations below 85% on the postoperative sleep study.
Nineteen (95%) of 20 patients achieved a successful outcome. The average preoperative respiratory disturbance index (RDI) was 52.7. The average postoperative RDI was 11.8 (
For patients with multilevel obstructive sleep apnea, minimally-invasive mandibular hyoid suspension appears to be highly efficacious for the treatment of hypopharyngeal airway obstruction when performed in conjunction with uvulopalatopharyngoplasty.
There is conflicting opinion regarding the clinical utility of removing small tonsils in children with obstructive sleep apnea (OSA). We sought to (1) determine if OSA improves after adenotonsillectomy (AT) in children with small tonsils; and (2) investigate the relationship between OSA resolution and tonsil size after AT.
Retrospective study of 1- to 18-year-old consecutive nonsyndromic children with OSA who underwent polysomnography before and after AT. Complete response was defined as obstructive respiratory disturbance index (RDI) < 1.5.
Seventy children (36 female) were included; mean age was 5.9 ± 4.3 years. Tonsils were categorized as 2+ (n = 20), 3+ (n = 36), and 4+ (n = 14). Preoperative RDI, obstructive apnea index (AI), and obstructive hypopnea index (HI) were similar regardless of tonsil size (
Tonsil size did not correlate with OSA severity. While a larger proportion of patients with 3+/4+ tonsils had complete response after surgery, significant improvement was seen in AI and saturation nadir even in those with 2+ tonsils.
Obstructive sleep apnea (OSA) is a serious medical condition that adds to patient morbidity and mortality. While treatment with positive airway pressure (PAP) is the standard of care, a significant portion of patients fail to adhere. Little is known about the subsequent management of patients who have refused or failed continuous positive airway pressure. We sought to identify rates of acceptance and adherence to PAP, as well as management and referral patterns of those who failed.
Retrospective cohort study in an academic hospital. All patients undergoing polysomnogram at a single institution during the months of March and April 2010 (n = 1174) were screened for OSA. Adult patients with apnea-hypopnea index (AHI) > 15 or 5 < AHI < 15 as well as Epworth Sleepiness Scale (ESS) >10 were included for subsequent analysis. Patients undergoing polysomnography were screened for OSA retrospectively using the electronic medical record (EMR). The subsequent management history including tolerance of PAP and referral to specialists upon failure was collected.
Of 1174 patients screened, 566 met inclusion criteria. Of 416 patients (74%) with follow-up information, 237 (57%) were ultimately adherent to PAP. Of 205 nonadherent patients, 86 had refused PAP immediately (42%). Sixty-one (30%) were referred upon failure or refusal. A total of 139 patients (68%) suffered from untreated OSA without referral to a specialist during a 3-year follow-up.
Despite the known sequellae of OSA, clinicians are neither treating nor referring a significant percentage of patients with OSA. Therapies other than PAP may be warranted in this population.
(1) Determine the effect of upper airway surgery (UAS) on continuous positive airway pressure (CPAP) pressure by systematic review and meta-analysis. (2) Determine if a decrease in CPAP pressure from UAS could increase CPAP adherence.
A systematic review and meta-analysis was performed. Studies were eligible for inclusion if a CPAP titration was performed both prior and following upper airway surgery in patients with obstructive sleep apnea (OSA). Studies that compared adherence to CPAP before and after upper airway surgery were included to evaluate the secondary objective.
A total of 11 articles involving 323 patients were included in the review. There was a mean reduction in CPAP pressure of 1.44 cmH2O [95% confidence interval [CI], –2.09 to 0.78], indicating that UAS reduced CPAP pressure on average. Four of the 11 papers with a total of 80 patients evaluated CPAP adherence. CPAP adherence was improved by 0.62 hours on average [95% CI, 0.22 to 1.01].
CPAP remains the mainstay treatment of moderate to severe OSA, but due to high levels of nonadherence, surgical intervention will play a role even in patients who are unlikely to be fully cured by surgery. UAS decreases the apnea-hypopnea index, improves symptoms, and modestly reduces CPAP pressure while improving CPAP adherence in the majority of patients. The evidence suggests that UAS may have an important adjunctive role on the management of OSA.
(1) Identify the amount of sleep disruption that occurs in the postoperative inpatient hospital setting. (2) Determine the relationship between sleep disruption and the use of postoperative narcotic for pain. (3) Determine if the postoperative hospital course is impacted by sleep disruption. Sleep disturbance is a common complaint among hospitalized patients. Decreased sleep and poor sleep quality have been found to be correlated with poor hospital outcomes and decreased wound healing.
Prospective cohort study. Fifty patients undergoing total hip or knee arthroplasty at Henry Ford Hospital in Detroit, Michigan, between January 2013 and November 2013 were asked to wear an actigraph during their postoperative hospital stay. Total sleep time, sleep efficiency, awake index, narcotic use, visual analog pain scores, and postoperative complications were analyzed.
A significant correlation was found between lower self-reported pain scores and total sleep time (
Better control of a patient’s pain improves sleep efficiency and total sleep time. Attention to decreased sleep disruption for hospitalized patients has the potential to improve patient satisfaction with hospital care and decrease length of stay.
(1) Understand that half of obstructive sleep apnea (OSA) patients failing positive airway pressure (PAP) attempt mandibular advancement device (MAD) therapy but still suffer from residual disease. (2) Describe how drug-induced sleep endoscopy (DISE) evaluates anatomical patterns of obstruction under conditions that mimic sleep and aids management in patients with incomplete response to MAD.
A review of 35 consecutive adult OSA patients, with continuous positive airway pressure intolerance and incomplete response to MAD therapy (apnea-hypopnea index [AHI] >15 or AHI >5 with persistent subjective symptoms), who underwent DISE with and without the MAD between 12/2010 and 8/2013. Data collected included demographics, body mass index (BMI), Epworth Sleepiness Score (ESS), polysomnography data, and management decisions after DISE. Each DISE video was retrospectively scored using the VOTE classification system by the same blinded reviewer (R.J.S.).
All patients had multilevel airway obstruction during baseline DISE. 32 (91.4%) obstructed in the velopharynx despite MAD use. 26 (74.3%) patients were recommended to undergo targeted surgery based on DISE findings with 21 (60%) completing it. Nineteen (54.3%) underwent additional medical therapy such as MAD or PAP adjustment. Twelve (34.3%) were treated with surgical and medical therapy. Subjective and objective outcomes were significantly improved in 15 patients with outcome data currently available (mean AHI 39.3 to 10.7,
In patients with incomplete response to MAD therapy, DISE with and without the MAD provides informs management decisions regarding additional medical or surgical options to augment the effectiveness of the MAD.
Measure obstruction length and height using drug-induced sleep endoscopy (DISE) in obstructive sleep apnea syndrome (OSA) patients and to evaluate their effects on predicting velopharyngeal surgery.
A single institution, prospective, nonrandomized trial of DISE in a consecutive group of patients undergoing velopharyngeal surgical procedure, which consisted of revised uvulopalatopharyngoplasty with uvula preservation and transpalatal advancement pharyngoplasty between July 1, 2012, and June 30, 2013. Eighty patients with OSA diagnosed by polysomnography were evaluated by DISE using dexmedetomidine before surgery. Obstruction length (defined as the distance from the most superior point of the collapse to the most inferior point of the collapse) and obstruction height (the distance from the posterior border of the nasal septum to the most proximal point of the collapse) were measured.
Out of 80 subjects studied, the mean obstruction length and obstruction height was 1.6 ± 0.8 (range was 0.4-3.8) cm, and 3.4 ± 1.0 (range was 1.1-5.0) cm, respectively. The obstruction length had correlations with body mass index (BMI), CT90, and lowest oxygen saturation (
Obstruction length and height can be accurately measured while apnea occurs during the patient’s drug-induced sleep. They are useful to help predict outcome to upper airway surgery in OSA.
Identifying the appropriate operation(s) for children with sleep-disordered breathing (SDB) remains a challenge, and current imaging modalities have major shortcomings. We have pioneered the use of long-range optical coherence tomography (LR-OCT) to provide real-time images of the upper airway (UA) during sleep and wakefulness. Here we present our first use of LR-OCT to image the UA of awake children. (1) Understand how LR-OCT produces high-resolution structural images by acting as an optical range-finder. (2) Recognize how LR-OCT can identify strictures and real-time collapse of the airway.
This study builds upon our experience using LR-OCT to image 58 children under sedation. Here 10 awake children (SDB, 4-15 years) underwent nasal endoscopy and LR-OCT. We designed a high-speed Fourier domain LR-OCT system. Imaging probe and fiberscope were transnasally inserted in tandem and axial images were rapidly acquired (spiral scan, 500-700 images, 30-40 seconds). 3D models of each airway were reconstructed.
Five airways yielded data suitable for 3D volumetric reconstruction, and identified the dominant site of airway obstruction as well as structure of the tonsils, adenoids, base of tongue, and epiglottis. Cross-sectional area of the axial airway level corresponding to these structures was calculated. Dynamic changes in 3D airway structure were visualized.
The feasibility of LR-OCT to identify regions of stricture and collapse in children’s airways was established. Hence, patient-specific surgical treatments can be developed for children with SDB. The next step is to transition to imaging children during sleep, as we have in adults.
(1) Determine the influence of drug-induced sleep endoscopy (DISE) on the surgical decision for upper airway stimulation (UAS) therapy. (2) Learn the limitations of drug induced sleep endoscopy.
This was a single-blinded cross-sectional study in which 4 surgeons with extensive experience with DISE reviewed blinded DISE video clips from 63 patients who were screened for participation in the STAR (Stimulation Therapy for Apnea Reduction) trial, a phase III trial of upper airway stimulation (UAS) of the hypoglossal nerve for moderate-to-severe sleep apnea (OSA). Each DISE clip was independently reviewed and graded by a surgeon who then predicted whether the patient was a candidate for UAS therapy.
Evaluators demonstrated a high level of 100% agreement with regard to the presence of palatal collapse in 81% of cases, but less complete agreement concerning hypopharyngeal collapse (64% of cases). The viewers had complete agreement with regards to the presence or absence of circumferential airway collapse in 59% of cases. The surgeons had a low level of complete agreement (44% of cases; mean kappa 0.343) as to whether a given case was a good candidate for UAS therapy.
DISE continues to be a highly subjective study. Previous evidence found that patients with circumferential airway collapse on DISE respond poorly to UAS. Additional training will be necessary in the future in order to increase agreement among surgeons as to which patients are the best candidates for UAS therapy.
Describe the therapeutic effect of upper airway stimulation (UAS) therapy withdrawal on objective and subjective measures of sleep apnea severity.
From a cohort of 126 participants in a prospective therapy effectiveness trial, 46 subjects were randomized to therapy “ON” and “OFF” groups. Primary outcomes measures were apnea-hypopnea index (AHI) and oxygen desaturation index (ODI) changes and secondary outcome measures included Epworth Sleepiness Scale (ESS), Functional Outcomes of Sleep Questionnaire (FOSQ), sleep architecture, hypoxemia, snoring, and blood pressure.
Groups did not differ at pretreatment baseline or at 12 months of therapy in polysomnography or self-reported measures. Following randomized controlled trial (RCT) therapy withdrawal, change in AHI and ODI significantly differed in “ON” and “OFF” groups (1.7 versus 18.2 and 1.6 versus 17.0 events/hour
Withdrawal of therapeutic UAS results in relapse of both subjective and objective measures of OSA.
Determine the relationship between surgical success and both preoperative drug-induced sleep endoscopy (DISE) airway caliber changes and volumetric magnetic resonance imaging (MRI) in patients with obstructive sleep apnea (OSA) undergoing transoral robotic assisted posterior glossectomy and uvulopalatopharyngoplasty (OSA-TORS).
From 2009 to present, as part of a nonrandomized prospective trial, patients with OSA undergoing OSA-TORS had preoperative DISE and pre- and postoperative volumetric MRI of the upper airway. Quantitative analysis of the endoscopy and MRI were compared with surgical success based upon pre- and postoperative polysomnogram, with success defined as postoperative apnea-hypopnea index (AHI) <20 and AHI decrease ≥50%. Preoperative MRI volumes were also compared against DISE changes.
Thirty-five apneics undergoing OSA-TORS underwent DISE, 21 received MRIs. DISE data showed that patients with surgical success had a smaller percentage decrease in overall airway collapse in the retroepiglottic (
Larger retroglottic airway volume on MRI correlated with greater lateral airway collapse during DISE, but not with surgical success. Successes after OSA-TORS had significantly smaller airway collapse in the retroepiglottic regions than nonsuccesses during DISE, possibly due to better baseline muscle tone, allowing for better ability to benefit from the relatively small change in airway volume that OSA-TORS provides. Preoperative quantitative DISE could be used to identify patients more likely to succeed after OSA-TORS.
Evaluate the difference in the postoperative complication rate between single and multilevel surgery performed on patients with obstructive sleep apnea (OSA).
A retrospective outcomes analysis was performed on 238 patients with OSA who underwent surgery from January 2011 to December 2013 under the care of the third author in a tertiary referral center. Complications were defined as unexpected events needing additional medical attention within 30 days of surgery. These included but were not limited to: emergency department visits, nasal packing, cautery in the outpatient setting, hospitalization, and need for return to the operating room. Early complications were those occurring within the first 24 hours of surgery while late complications were defined as those occurring after 24 hours.
Of 238 patients, 88 underwent single level surgery and 150 underwent multilevel surgery. There were none lost to follow-up. The main complication was bleeding. The complication rate was 5.7% in the single level group and 14.7% in the multilevel group. The difference in complication rate was significant, with
There is an overall higher complication rate in obstructive sleep apnea patients undergoing multilevel surgery. However, the overall risk remains low and most complications are minor. This reminds us to be cautious in the management of such patients, especially if they have had multiple procedures performed.
Determine safety and effectiveness of targeted hypoglossal neurostimulation sleep therapy system for obstructive sleep apnea (OSA). Titration with multi-contact electrode and multi-channel pulse generator (IPG) allows stimulation of multiple areas of the proximal hypoglossal nerve permitting identification of optimal tongue position in each patient.
A total of 105 adults were screened in this prospective, multicenter, single-arm study. Inclusion criteria were continuous positive airway pressure (CPAP) failure/intolerance, apnea hypopnea index (AHI) > 20, and body mass index (BMI) > 37. 56 patients meeting inclusion/exclusion criteria were surgically implanted with the unilateral hypoglossal nerve stimulator electrode and IPG (aura6000TM System, Imthera Medical, San Diego). Patients were evaluated at 1, 3, 6, and 12 months. Outcomes included AHI, oxygen desaturation index (ODI), Epworth Sleepiness Scale (ESS), Sleep Apnea Quality of Life Index, and EQ-5D quality of life questionnaire.
Postsurgical transient tongue paresis was observed in 5 out of 56 patients (8.9%); all resolved spontaneously. Four patients withdrew, leaving 52 subjects to complete the study by September 2014. All were male, with mean age of 54.8 ± 10.6 years, and mean BMI of 30.4 ± 3.6. Preliminary data at month 3 showed significant decrease in AHI by 43.7% from 50.5 ± 18.4 to 26.7 ± 19.8 (
Surgical implantation of targeted hypoglossal neurostimulation sleep therapy system appears to be a safe and practical treatment option for OSA. Preliminary data shows significant improvement in objective and subjective outcomes. Final safety and effectiveness will be determined.
(1) Assess the effectiveness of multilevel surgery in the treatment of obstructive sleep apnea (OSA). (2) Analyze outcomes based on reduction of apnea hypopnea index (AHI) and positive airway treatment pressures.
Case-series review in a tertiary referral center. A total of 44 patients underwent multilevel OSA surgery between November 2009 and September 2013. Depending on the preoperative examination and OSA severity based on sleep study, patients underwent multilevel surgery including nasal, oropharyngeal, transoral robotic, tongue base, hyoid, and/or orthognathic surgery. Follow-up sleep studies at 4 months were obtained and compared with preoperative data.
Overall AHI was significantly reduced from a mean of 44.5 to 19.9 (
Targeted multilevel OSA surgery in this cohort was successful in an overall reduction of AHI and CPAP pressures. The maximum improvement in AHI was seen in patients with moderate OSA and in those who had an orthognathic procedure.
Report improvements of childhood obstructive sleep apnea (OSA) and hypertension after adenotonsillectomy.
Case series with planned data collection of 50 consecutive OSA patients (36 boys and 14 girls; mean age, 7.6 ± 2.8 years) who underwent plasma knife total tonsillectomy and adenoidectomy between January 2010 and March 2013. Body mass index (BMI), apnea-hypopnea index (AHI), systolic blood pressure (SBP), and diastolic blood pressure (DBP) were assessed at baseline and at ≥6 months postoperatively. Changes of these parameters were statistically analyzed.
The mean values of BMI z-score, AHI, SBP, and DBP were 1.91 ± 0.27, 15.9 ± 17.2, 102.8 ± 16.8 (mm Hg), and 67.4 m ± 12.6 (mm Hg), respectively. The median follow-up period was 12 months. Eighteen patients (36%) were cured after adenotonsillectomy. Postoperatively, adenotonsillectomy reduced AHI (Δ = −13.3 ± 17.7,
Hypertension is not uncommon in children with OSA. Decreasing hypertension rate indicates that reduction of AHI is not all that matters after adenotonsillectomy in childhood OSA. However, pediatric patients with severe OSA and hypertension need careful management of their elevated BP despite surgical treatment.
Upper airway collapse is the major reason of obstructive sleep apnea (OSA). However, the site and mechanism of the obstruction remains unclear. To measure the pharyngeal wall floppiness under different pressures, a novel method and technique is introduced in the present study.
Forty-seven normal subjects (male: 32; mean age, 37.9 years) and 49 OSA patients (male: 6; mean age, 41.45 years) were recruited in this prospective clinical study. The pharyngeal cavity volumes were measured by means of acoustic reflection under positive (10 cmH2O) and negative (–10 cmH2O) pressures. The pharyngeal wall floppiness was calculated from the difference of pharyngeal cavity volumes under positive and negative pressures divided by the sum of the volumes under different pressures.
The pharyngeal wall floppiness was 0.19 ± 0.11 in normal subjects and 0.24 ± 0.07 in OSA group with a significant difference (
The OSA population had greater pharyngeal wall floppiness. The age dependent of pharyngeal wall floppiness in normal subjects implied that aging might play important roles in the development of OSA. The measurement of pharyngeal wall floppiness could be a useful and valuable parameter in diagnosis of OSA and predicting the adherence in continuous positive airway pressure (CPAP) treatment.
Retrospectively investigate the taste disturbance (TD) following endoscopic Coblator open tongue base resection (Eco-TBR) for the treatment of obstructive sleep apnea syndrome (OSA).
Eighty patients with OSA who failed CPAP therapy and then underwent modified UPPP combined with Eco-TBR were enrolled in this study. TD in the postoperative questionnaire was examined. The 3-drop-method gustatory function test was used to study the taste status preoperatively and at 7 days, 1 month, and 3 months postoperatively.
Six female and 74 male patients with OSA (mean age, 42.6 years; mean apnea-hypopnea index, 48.5/h) had a minimum follow-up of 3 months and complete data available for analysis. One patient had postoperative oral bleeding. No long-term obvious dysphagia was encountered. Twelve patients had obvious TD in 4 basic tastes (sweet, sour, salty, and bitter). Eight patients still had the change of taste sensation up to postoperative 3 months; however, the TD severity decreased and did not impact the patient’s regular social life.
This study shows coblator open tongue base resection may increase the likelihood of taste disturbance postoperatively. Patients with taste disturbance after Eco-TBR may gradually recover their taste function over time.
(1) Determine if there is significant geographic variation in surgical charges for endoscopic sinus surgery (ESS) across states. (2) Understand factors that influence charges.
The State Ambulatory Surgery Databases (2010) for Florida, Iowa, New York, and North Carolina were analyzed, extracting cases of adult endoscopic sinus surgery. Demographic, diagnostic, procedural, insurance, and charge data were tabulated. Extent of surgery was quantified by number of sinusotomies and other nasal procedures (eg, septoplasty) performed. Variation in state-to-state total charges for ESS was determined adjusting for demographic and procedural parameters.
A total of 22,350 ambulatory ESS cases were examined across 4 states (mean age, 48.5 years; 51.6% female). Private insurance and Medicare were the primary payers in 69.5% and 19.3% of cases, respectively. Image guidance was utilized in 21.0% and polyps were present in 26.8% of cases. There was wide variation in the distribution of sinusotomies per case performed: Florida had the highest percentage of 5 sinusotomy cases (18.8%) versus 15.9% for New York and only 7.0% for Iowa (
Considerable state-to-state variation in charges for ambulatory ESS exists. These data will become increasingly important as mandates for charge and cost transparency for the healthcare consumer manifest nationally. Efforts to determine reasons for these cost variances should be undertaken.
A physician extender is a licensed health care provider who performs medical activities typically performed by a physician. The term encompasses highly trained health care professionals such as physician assistants, nurse practitioners, and midlevel practitioners. In our academic, tertiary care otolaryngology residency-training program, a physician extender was recently hired. The objective of this study was to evaluate his impact on resident quality of life and education as well as his productivity.
All otolaryngology residents at an academic tertiary care medical center were issued a questionnaire that they answered anonymously. All inpatient consults seen by the physician extenders and residents over an 18-month period between June 2012 and December 2013 were prospectively captured and evaluated.
The results of the survey indicated that all residents unanimously agreed that a physician extender had a positive impact on resident education, patient care, and quality of life. There was no statistically significant difference in the types of consults seen by a physician extender and those seen by a resident. The physician extender enhanced departmental productivity on the inpatient consultation service.
Physician extenders are valuable assets to academic otolaryngology residency programs. Their presence enhances patient access, care, and departmental productivity. They have a positive impact on resident quality of life and augment resident education.
The speakers’ intention is to explore the medical climate today as it pertains to practicing medicine as a private otolaryngologist: specifically, the challenges a provider faces today and potentially downstream. During turbulent times, medical professionals can often become fixated on what they do best and lose sight peripherally as to what is influencing the market and as a result what additional options may present themselves that would allow a practice to thrive despite the challenges. Areas of focus and learning will include: (1) The increasingly elusive target audience: (a) who makes the buying decision, (b) effects of the Internet and social media on buying decisions. (2) Methodologies to attract the right patient type: (a) practice differentiation—narrow and deep versus shallow and wide, (b) attracting a higher value patient type, (c) marketing as a system versus a series of random activities, (d) traditional media marketing and its applications today in medicine, (e) new media marketing and its applications today and going forward in medicine. (3) Overcoming today’s challenge by driving a seven-figure hearing component. The audience will have a clear introduction to medical practice marketing in today’s “instant gratification” climate when pitted against declining reimbursements, a savvy consumer, and fear of acquisition.
Arteriovenous malformations (AVMs) often cause disfigurement and severe functional disturbances. An improper approach can unlock an explosive growth in the AVM and present a very high risk of relapse. Recurrent AVMs are much harder to cure. Intraoperative massive bleeding is a tangible risk if AVMs are treated surgically without preparatory endovascular embolization. The study’s aims were: (1) Recognize and clearly diagnose a cervicofacial AVM. (2) Describe the indications and techniques to treat cervicofacial AVMs. (3) Analyze the critical importance of a combined endovascular and surgical approach.
The most accepted indications and techniques concerning head and neck AVMs are gathered from a review of the literature and compared with the personal experience of the authors with 10 AVMs of the soft tissues of the head and neck and 4 AVMs of the facial bones. All patients underwent preoperative endovascular embolization with n-butyl cyanoacrylate followed by surgical removal of the malformation within 48 hours of the procedure.
One early case of AVM of the maxilla was complicated by massive intraoperative hemorrhage despite preoperative embolization. One maxillo-mandibular AVM recurred 2 years after the treatment. In all patients an improvement in cosmetic appearance was documented. Smaller AVMs were easier to manage and had the best results.
An aggressive combined endovascular-surgical treatment seems to be the only “curing” strategy for head and neck AVMs. A thoughtful preoperative balance must be made within a multidisciplinary team and clearly discussed with the patient.
Evaluate the aesthetic impact of our modified septal framework’s self-stabilizing design as a self stabilizing masterpiece.
Retrospective cohort study at an academic tertiary care medical center. A total of 114 patients underwent an extracoporeal septoplasty between 2008 and 2012. Eleven parameters of facial analysis were examined closely on every patient’s photograph.
Patients had great aesthetic improvement. In fact, a high percentage of patients had a better profile line, central axis, nasal base symmetry, sheen’s line, tip symmetry, tip projection, and nasolabial angle. However, we also noticed a widening of the middle third in 27% of the patients and a filling of the nasofrontal angle in 21%. The latter showed a downward trend throughout the years.
The modified extracorporeal septoplasty has a positive impact on aesthetic analysis.
(1) Examine resident interest in otolaryngology subspecialty fellowship and factors affecting that interest over time and throughout residency. (2) Examine changes in fellowship availability and match rate over time.
Data regarding fellowship interest, influencing factors, and demographics were extracted from the 2008-2013 Section for Residents and Fellows-in-Training annual survey and examined in uni- and multivariate analyses. Historic fellowship match data available through match resources for pediatric otolaryngology, laryngology/broncho-esophagology surgery, rhinology, and neurotology were collected.
Over 6 years, a total of 1958 residents and fellows responded to the survey. A statistically significant decrease in fellowship interest was seen between junior (PGY-1 or PGY-2/3) and senior residents (PGY-4/5), with 79.9%, 73.3%, and 61.6% of PGY-1, PGY-2/3, and PGY-4/5 residents, respectively, planning to pursue subspecialty training (
Interest in fellowship continues to be high, but desire to pursue fellowship training decreases with increased residency training. This decision is multivariate in nature. While most subspecialties have grown slowly over time, the match rate continues to be variable due to fluctuations in application numbers.
To view the utility of comparative 2D finite element analysis (FEA) of rhomboid flap models in analyzing how varying skin stiffness and directionality affects closure of a facial defect.
Two-dimensional (2D) finite element models based on prior validated 2D. Nonlinear hyperelastic human skin models of rhomboid surgical flaps were parameterized for reconstruction of a 2 × 2 cm facial defect. Skin stiffness and directionality were varied to simulate several real-patient factors such as age, radiation, sex, etc. ANSYS 12.1 was used to compute the stress/strain and reaction force results.
The challenges of defect closure often include intrinsic factors of a patient’s skin. As skin stiffness and directionality vary, the stress/strain patterns vary accordingly. FEA gives surgeons the ability to visually see how certain patient-specific skin factors affect closure of a defect, allowing for anticipation of challenges such as dog-earing or high strain fields near critical structures (eye, ear, and hairline).
The utility of finite element models for analyzing and planning pre-surgical endeavors has been well-documented. Our study is the first of its kind for comparative surgical planning for varying skin conditions.
Self-esteem is one’s attitude toward oneself. It is one of the most important psychological aspects of rhinoplasty. Some findings indicate the improvement of patient self-esteem after the operation. The aim of this study was to compare self-esteem in patients seeking aesthetic or functional rhinoplasty.
A total of 45 patients ranging in age from 17 to 36 filled out the Rosenberg Self-Esteem Scale (RSES) over a 3-month period. RSES consists of 10 items measuring general self-esteem. The subjects took a validated form of RSES preoperatively. Twenty-one aesthetic surgery patients and 21 functional surgery patients had filled out the questionnaire and 3 patients had left it blank.
Using
The findings of the present study showed that aesthetic rhinoplasty patients had lower self-esteem in comparison with functional rhinoplasty patients.
To analyze whether the nasal valve cartilage repositioning procedure described here results in a significant improvement in patients with obstructive sleep apnea (OSA).
This is a prospective case series conducted at a university public hospital from 2011 to 2014. Adult patients who had OSA, nasal obstruction with valve collapse, and body mass index less than 30 were included in the study. All patients had a cartilage repositioning L-strut septoplasty via full transfixion incision. Specifically, the septal dorsum is exposed, released from the upper lateral cartilages and bony septum, and repositioned in the midline and fixated to the nasal spine, thus restoring the L-strut position. In addition, the nasal sidewalls were repaired using the Alar™ endonasal stent device to reposition the upper lateral and lower lateral cartilage after release into positions of increased overlap, thus increasing the diameter of the nasal valve. Preoperative and postoperative (3 months) polysomnograms were obtained. Statistical analysis using the paired
Fifteen patients were included in this study. Average apnea-hypopnea index (AHI) scores preoperatively were 24. Postoperative AHI scores averaged to 13, a reduction of 54% (
The comprehensive repair of the nasal valve including repair of the nasal sidewalls and septal L-strut can significantly improve the severity of OSA for select patients. This is a fast and minimally invasive approach to consider in patients with OSA and nasal valve collapse.
Describe our novel minimally invasive technique for closure of nasal septal perforations.
We describe our experience in a series of patients from 2 London teaching hospitals treated using the same surgical technique. Closure of the defect was undertaken using one inferiorly based nasal floor mucosal flap and a contra-lateral superiorly based vascularized septal mucosal flap. This was achieved by a closed endonasal approach with a porcine dermal collagen sheet interpositional graft (Permacol) placed on the more concave side of the perforation. The mucosal flaps are used to cover the repair and sutured in place.
Septal perforations of up to 2-cm diameter were successfully repaired in greater than 90% of cases over a 36-month follow-up period.
Our novel technique has proved effective in closure of septal perforations. Permacol is a durable graft, utilizing acellular cross-linked collagen matrix, used commonly in abdominal hernia repair. We found Permacol to be a biocompatible graft with the ability to resist dessication if there is slow re-epithelization or partial exposure, making it a robust and easy to use interpositional graft with no morbidity from graft harvesting. The use of local intranasal mucosal advancement flaps allows a minimally invasive approach without any external incisions or scars. Potential limitations are the size of the pedicled flaps for very large perforations, or the lengths of the flaps for very anterior defects. For the majority of septal perforations the authors feel this technique offers an effective minimally invasive option with low morbidity.
(1) Determine the incidence of facial fractures. (2) Characterize the type of craniofacial injuries due to bicycle trauma.
Using CPT codes, we completed a query of facial fractures treated at a tertiary medical center between 1999 and 2012. Individual chart review of 1108 patients revealed 28 patients who were treated for facial fractures secondary to bicycle accidents.
Of the 28 patients identified, 86% (n = 24) were male and 14% (n = 4) were female. The median age was 27.5 with a range from 4 to 78 years. Male patients between the ages of 13 and 39 showed the highest incidence of injury. Alcohol was involved in 18% (n = 5) of cases. A total of 18 (64%) patients were hospitalized, with 28% (n = 5) of hospitalized patients admitted to the intensive care unit. The most common injury type was nasal fracture (46%, n = 13), and the craniofacial region most commonly injured was the mid-face (50%, n = 14), with tripod fractures (36%, n = 5) and Le Fort I fractures (29%, n = 4) as the most likely injuries. Ejection from the bicycle was the most common mechanism of injury cited (50%, n = 14). Though only 18% (n = 15) of patients were involved in a collision with a motorized vehicle, all of these patients required hospitalization. Complex surgery was required in 54% (n = 15) of patients. Nine patients (32%) required closed reduction of a fracture and 4 (14%) underwent maxillomandibular fixation.
Bicycle accidents can cause significant craniofacial injuries with many patients requiring hospitalization and surgery, especially when a motor vehicle is involved.
The complexity of the nasal tip structure and the impact of surgical holder maneuvers makes prediction of the final outcome very difficult. Therefore, no technique alone is enough to correct the numerous anatomic presentations adequately being the preoperative planning, the basis of rhinoplasty. This study’s aim is to present results of rhinoplasty, by gradual surgical approach to nasal tip definition based on anatomic features, and evaluate the degree of satisfaction of patients after the surgical procedure.
A retrospective historical cohort study of the medical charts of 533 patients of both sexes who underwent rhinoplasty from January 2005 to January 2012. Cases were allocated into 7 groups: (1) no surgery on nasal tip, (2) interdomal breakup, (3) cephalic trim, (4) domal suture, (5) shield-shaped graft, (6) vertical dome division, and (7) replacement of lower lateral cartilages.
Group 4 was the most prevalent. The satisfaction rate was 96%, and revision surgery occurred in 4% of cases.
The protocol used allowed the association of the gradual surgical approach to nasal tip definition with the nasal anatomic characteristics, high rate of satisfaction with the surgical outcome, and low rate of revision.
Discuss options for midline nasal suture during 2-flap palatoplasty (2FPP). Compare effects of patient demographics, Veau class, associated syndromes, surgeon experience, and use of a previously unreported exposed inverted horizontal mattress suture for nasal mucoperiosteal closure on fistula rates and velopharyngeal insufficiency (VPI).
Retrospective case series review of all children who underwent 2FPP by the attending surgeon (J.J.M.). Fifty-five consecutive patients were analyzed over a 5.5-year period. Study variables were obtained from multidisciplinary craniofacial/cleft records. All patients underwent 2FPP with intravelar veloplasty using the suture technique described herein. No patients were excluded from primary review and statistical analysis.
Eighty-nine percent of patients were Veau class 2 or 3. Twenty-four (44%) patients had an associated syndrome. Patients with a lower Veau class were 3.6 times more likely to have an associated syndrome (
Our use of an exposed inverted horizontal mattress suture for nasal mucoperiosteal closure during 2FPP appears safe and is comparable with the lowest published rates of postoperative fistula and VPI. Further standardized studies are needed in this area.
(1) Analyze the advantages and disadvantages of immediate endosseous dental reconstruction using osteocutaneous radial forearm free flap (OCRFFF). (2) Describe the “double barrel” technique for dental reconstruction following OCRFFF.
A 61-year-old man with previous hard palate squamous cell carcinoma (SCC) and fibula flap reconstruction complicated by osteoradionecrosis then underwent OCRFFF for secondary reconstruction of the maxilla using the “double barrel” technique. The Straumann system was used to immediately place 3 endosseus implants in the radial bone graft and one in the previously bone-grafted site. The purpose of this case report is to evaluate the methodology and outcome of immediate dental reconstruction with endosseous implants into an OCRFFF, which is traditionally thought to be an unsuitable graft for dental implants because of inadequate bone thickness. Outcome measures include hardware stability, aesthetics, and function. Aesthetics and function were subjectively measured through patient and surgeon satisfaction. Additionally, hardware stability was measured through follow-up imaging studies and functionality.
Both patients and physicians concluded positive functional and aesthetic outcomes using this reconstruction technique.
Use of a double-barrel technique harvest of an OCRFFF provides adequate bone for immediate endosseus dental implants with improved aesthetic and functional outcomes over other reconstructive techniques.
(1) Develop a methodology to eliminate the confounding effect of the nasal cycle when comparing pre- and postsurgery nasal resistance measurements. (2) Illustrate this methodology by reporting nasal resistances derived from computational fluid dynamics (CFD) simulations in a test subject using computational models that span the full range of mucosal engorgement associated with the nasal cycle.
A cohort of 40 nasal airway obstruction patients was reviewed to select the one patient with the greatest reciprocal change in turbinate engorgement between pre- and postsurgery computed tomography (CT) scans. Ten 3-dimensional anatomically accurate nasal cycling CFD models were created based on the pre- and postoperative CT scans. The thickness of the inferior turbinate, middle turbinate, and septal swell body was systematically increased/decreased by adding/removing layers of pixels around these structures using medical imaging software.
After surgery (septoplasty), without adjusting for the nasal cycle, nasal resistance decreased by 17% on the left side and by 69% on the right side, and total resistance decreased by 53%. However, after adjusting for cycling, the unilateral nasal resistance decreased by 50% and 43% on the left and right sides respectively, while bilateral resistance decreased by 47%.
By simulating the nasal cycle using computational models, changes in nasal resistance due to surgery can be distinguished from physiological changes due to the nasal cycle. This ability can lead to more precise objective comparisons of pre- and postsurgery nasal resistance measurements and potentially more accurate virtual presurgery planning.
(1) Determine the most common causes of traumatic nasal deformities referred to pediatric otolaryngology. (2) Examine the efficacy of closed reduction of nasal fractures in children and adolescents based on the parents’ and surgeon’s ratings of post-reduction nasal symmetry.
Case series and chart review within an urban pediatric otolaryngology practice.
One hundred cases of traumatic nasal deformity met inclusion criteria over a 3-year study period. The mean age at presentation was 13 years (4 weeks-18 years); 55% were male and 70% were over the age of 12 years. The most common mechanism of injury was sports-related trauma (28%), followed by accidental trauma (21%), interpersonal violence (10%), motor vehicle collision (6%), and alcohol-related (2%). Of these 100 cases, 21% underwent closed reduction within a 14-day period following injury. All patients achieved symmetry in the operating room immediately following reduction. At the postoperative visit (7-10 days following surgery), the operating surgeon was satisfied with nasal symmetry in 43% of cases and the parent(s) was satisfied in 81% of cases. Both parent and surgeon were satisfied with postreduction symmetry 33% of the time.
The most common source of traumatic nasal deformity in children and adolescents differs from the most frequent mechanisms of nasal trauma in adults. In cases meriting operative intervention, parents appear to be satisfied with early postoperative results following closed reduction in approximately 80% of cases; however, a result in which both parent and surgeon agree with successful re-establishment of symmetry occurs in only 1/3 of cases.
(1) Describe the muscle-nerve-muscle (MNM) reinnervation technique, which involves implanting a graft to serve as a conduit between an innervated donor muscle and a denervated recipient muscle. (2) Analyze the effects of MNM reinnervation with and without electrical stimulation and exogenous testosterone on functional recovery following rat facial nerve injury.
A prospective controlled animal study. Facial nerve branches to the whisker pads of 24 adult male Sprague Dawley rats were harvested and each rat was then randomly assigned to 1 of 3 treatment groups of 8 rats each: no graft (control), MNM grafting alone (MNM), or MNM grafting + electrical stimulation (ES) and testosterone propionate (TP) (MNM+). MNM grafts were implanted from the functioning to the nonfunctioning whisker pads in the experimental groups. One experimental group underwent an ES and TP protocol. Whisker movement was assessed by behavioral observations, electromyographic recordings, and video analysis.
Recovery of coordinated movement was displayed at 16 weeks by 0% of the control animals, 71% of the MNM animals, and 85% of the MNM+ animals. Electromyographic recordings demonstrated electrical conductance across grafts in both MNM and MNM+ animals. Histologic analysis of the MNM grafts demonstrated growth of myelinated fibers across nerve grafts in both MNM and MNM+ animals.
This study demonstrated not only that reinnervation following MNM grafting can improve tone and movement in a selected muscle following a facial nerve injury, but also that therapy with electrical stimulation and exogenous gonadal steroids further enhances the recovery of these functional measures.
The ideal animal model for nerve regeneration studies is an object of controversy because all models described by the literature have advantages and disadvantages. Small animals such as rats have been repeatedly used in experimental procedures because of their easy caretaking and handling, resistance to manipulation and infections, and low cost. In this case, rats have the additional benefit of tolerating bilateral facial paralysis. This study aimed to describe the histologic and functional (electroneuromyographic) patterns of the mandibular branch of the facial nerve of Wistar rats in order to create a new experimental model of facial nerve regeneration.
Forty-two male Wistar rats were submitted to neurophysiologic evaluation by a nerve conduction test of the mandibular branch of the facial nerve to obtain the compound muscle action potential. Twelve of these rats had the mandibular branch of the facial nerve surgically removed and submitted to histologic analysis (total axon number, partial axonal density, and axonal diameter) of the proximal and distal nerve segments.
There was no statistical difference in the functional and histologic variables studied.
These new histologic and functional standards of the mandibular branch of the facial nerve of rats establish an objective, easy, and greatly reproducible model for future facial nerve regeneration studies.
Use acoustic rhinometry to objectively measure the functional outcomes of endonasal spreader grafts in patients undergoing surgical correction of internal nasal valve collapse.
Eighteen adult patients undergoing open septoplasty with unilateral or bilateral endonasal spreader graft placement were recruited. Patients were asked to undergo preoperative and postoperative acoustic rhinometry to measure changes in cross-sectional area of the internal nasal valve. Postoperative subjective nasal symptoms as measured by SNOT-22 and NOSE scores were also compared to preoperative values.
Patients undergoing septoplasty with endonasal spreader graft placement had a statistically significant increase in the cross-sectional area of the internal nasal valve (
This study provides objective evidence of an increase in internal nasal valve area after placement of endonasal cartilage spreader grafts in combination with septoplasty.
We present our institutional experience with dynamic time-resolved magnetic resonance angiography (DTR MRA) with delayed venous imaging for free fibula flap (FFF) patient selection. We sought to (1) determine the sensitivity of the test for vascular anomalies predisposing to limb-threatening complications and (2) assess the impact of the venous phase findings in patient selection.
Retrospective review of 46 patients considered for mandibular reconstruction with FFF in an academic tertiary setting from 2009-2012. A DTR MRA was performed preoperatively in all cases. Both imaging and physical examination findings were used to determine patient eligibility for the procedure.
Thirteen patients (28.2%) had findings on DTR MRA excluding flap harvesting from the preferred leg, with atherosclerosis (n = 8) and anatomic variations (n = 4) being the most common findings. Eight of these patients (61.5%) underwent harvesting from the opposite leg, while 5 underwent reconstruction with a different bony flap. Only 2 of these 13 patients (15.3%) had physical examination findings excluding reconstruction with FFF. DTR MRA was significantly more likely to detect potentially limb threatening vascular anomalies than physical examination (
DTR MRA is significantly more sensitive than physical examination in detecting limb-threatening anatomic variations and vascular pathology prior to FFF reconstruction. The venous phase allows identification of oligosymptomatic venous anomalies that, while uncommon, may predispose to significant morbidity. These findings justify routine use of this imaging modality.
A wide array of surgical techniques has been developed to address internal nasal valve collapse. In particular, butterfly grafts and spreader grafts are used ubiquitously without any objective comparison being made on the efficacy of these approaches. The objective of this study was to quantitatively assess the effect that these techniques have on lateral nasal wall compliance.
A total of 11 fresh nonfixed cadavers (22 valves) were utilized for this study. Baseline measurements of lateral wall compliance were performed using a tension gauge and a novel procedure (herein described), and each nasal valve was measured independently. The valves were augmented with butterfly graft, endonasal spreader graft, and open spreader graft. Lateral nasal wall compliance was measured after each technique, and statistical analysis was performed.
There was an increase in force required to displace the lateral nasal wall compared with baseline after butterfly and endonasal spreader techniques (
This cadaveric study describes the application of a novel assessment tool used to quantitatively compare different grafting techniques used in functional rhinoplasty. Butterfly grafts are the most effective in strengthening the lateral nasal wall. Endonasal spreader grafts are also effective to a lesser degree. Open spreader techniques had no effect on the compliance of the lateral nasal wall.
Dynamic time-resolved magnetic resonance angiography (DTR MRA) is a novel imaging algorithm that allows for better visualization of small-caliber vessels when compared with standard MRA. We sought to estimate the technique sensitivity when compared with intraoperative findings.
Retrospective review of 25 patients undergoing reconstruction with free fibula flap at an academic tertiary setting from 2009 to 2013. Preoperative DTR MRA was performed in all cases. Two radiologists performed blind reviews of the images and their findings were compared with surgical descriptions of the perforator anatomy.
Surgical exploration identified 32 perforators while DTR MRA identified 45 vessels. The technique confirmed the presence of perforators in 22 out of 23 patients with at least one perforator, and their absence in 1 out of 2 patients who had a negative exploration. There was a significant correlation in the number of perforators identified clinically and radiologically in each case (
DTR MRA is a highly sensitive technique for determining the presence and location of cutaneous perforators in patients undergoing reconstruction with free fibula flap. The majority of the false-positive findings corresponded to vessels located within 30 mm of a confirmed perforator; we hypothesize that they could represent distal branching patterns presenting radiologically as separate entities. These results compare favorably to perforator mapping with standard MRA techniques.
Reconstruction of oromandibular defects in the setting of previous treatment, or significant patient comorbidities, presents a significant challenge. Although free tissue transfer has shown success, it is not without considerable risk, especially in patients with poor baseline functional status. In these patients, regional pedicled flaps may provide a more suitable alternative. The combined temporalis muscle and temporoparietal fascia flap is a versatile option for oromandibular reconstruction in a previously treated field, or in patients with severe comorbidities and poor functional status. Our objective was to report our experience using a combined temporalis muscle and temporoparietal fascia flap for reconstruction of oromandibular defects in high-risk situations.
Three patients were identified, medical records were reviewed, and their clinical courses were described. Functional outcomes were reviewed. We include a discussion of the relevant surgical anatomy and operative technique. All patients had previously undergone extensive treatment. They needed additional ablative surgery for different reasons: new malignancy, intractable trismus, and osteoradionecrosis. A combined temporalis muscle and temporoparietal fascia flap was used to reconstruct the oromandibular defects in each patient.
All flaps survived. Functional status improved in all patients. There were no significant operative or postoperative complications.
The combined temporalis muscle and temporoparietal fascia flap provides a reliable option for reconstruction of complex oromandibular defects in high-risk situations. In previously treated fields, the transfer of a vascularized flap into the wound hastens healing and improves the quality of native oral cavity tissue.
There is a paucity of data regarding the role of the vastus lateralis free flap (VLFF) in head and neck reconstruction. Our objectives were to (1) describe the flap outcomes in this setting and (2) identify ideal clinical scenarios for its use.
Retrospective review of 7 patients undergoing reconstruction with a VLFF at an academic tertiary institution between 2009 and 2013. Demographics, indications, complications, and outcomes were retrieved.
There were 4 males and 3 females with a mean age of 54.7 years. Indications included skull base reconstruction (n = 3/43%), scalp/calvarial defect (n = 2/28%), maxillary (n = 1), and exposed pharyngeal cervical spine hardware (n = 1). The myofascial component length ranged from 7 to 20 cm, and width ranged from 6 to 11 cm, with a mean area of 102 cm2 (range, 35-240). The mean pedicle length was 11.3 cm. Handheld (n = 3) or implantable (n = 4) Doppler was used for monitoring, and there were no flap losses. The flap was skin grafted in 3 cases with no reported graft loss. The mean intensive care unit stay was 1.1 days (0-3) and length of stay was 7.8 days (5-13). Complications included wound infection (n = 1) and myocardial infarction (n = 1) in a patient with significant comorbidities. The donor site was closed primarily in all cases, with no significant donor site morbidity reported.
The VLFF is an underutilized option in head and neck reconstruction. This flap provides a large amount of soft tissue that can be harvested in supine position and with minimal donor site morbidity. Given its long pedicle and variable myofascial component that can be tailored to a wide range of defects, the VLFF appears ideal for skull base reconstruction.
Investigate if facial fractures predispose patients to developing Parkinson’s disease. Facial trauma ranges from lacerations to complex facial fractures. These fractures can result from sports, motor vehicle collisions, or assaults. The long-term neurologic effects of facial fractures have not been studied. Significant force is required to break midface buttresses or the mandible. Such force is transmitted toward the cranial vault contents. The location of the basal ganglia along the skull base predispose this area to higher strain. Chronic traumatic encephalopathy (CTE) shows similar neurologic damage related to repeated head injuries, as seen in the NFL and boxing.
A total of 146 Parkinson’s patients were recruited from the neurology clinic. They were given a voluntary survey. This survey consisted of demographic questions: sex, age, age of diagnosis, involvement in sports, and history of facial fractures. The incidences of facial fracture ICD9 820.0 were analyzed with Wolfram Alpha and then chi-square.
Twenty-two of 146 (15%) had a positive history of facial fractures. Of the 22, 9 (6%) experienced multiple fractures. Twenty-six of 146 (17.8%) patients were involved in contact sports, with 7 out of 26 patients having fractures and participating in sports. Utilizing Wolfram Alpha, the incidence of ICD9 820.0 was calculated to be 1 out of 4100 (0.024%) in the US population. A chi-square test comparing our results showed a
Based on these statistically significant results, patients who experience facial fractures show an increased predilection for developing Parkinson’s disease.
(1) Review current validated scar assessment tools and (2) describe the impact of scar cosmesis perception on body image and quality of life.
Three independent reviewers performed comprehensive searches and identified 680 English language studies published between 1950 and 2014 (data sources: Medline, EMBASE, Cochrane Library, and Web of Science). Literature including case series, cross sectional studies, meta-analyses, and reviews was then screened and selected according to strict inclusion/exclusion criteria.
Scar assessment: Review included Vancouver Scar Scale, Patient and Observer Scar Assessment Scale, Manchester Scar Scale, Wound Evaluation Scale, and Western Scar Index. Validated qualitative assessment tools were clinically more useful than their quantitative counterparts. Patient perception input increased validity. Subjective satisfaction rating had little correlation with objective assessment of scarring. Perceptions: The size of defect did not correlate with impact, however location and visibility did. Psychosocial distress correlated with subjective severity. The large impact on physical and psychosocial quality of life (ascertained by generic and symptom-specific validated assessment tools, as well as qualitative studies with interpretive phenomenologic analysis) is not to be overlooked.
Careful selection of scar assessment tools is vital to gauge severity and plan further treatment. No consensus exists on the single most appropriate tool. A validated assessment tool is important in the assessment of scarring. There is a tendency to underestimate and thereby worsen the impact of scarring on patients’ quality of life. Further studies are required, particularly in the context of thyroid surgery.
(1) Find out the proportion of vegetarian patients in our department and their knowledge, views, and preferences in receiving nonvegetarian medications. (2) Describe commonly prescribed ear, nose, and throat (ENT) medications in our department and whether they are suitable for vegetarians.
A questionnaire survey was performed in the ENT department of a large southeast England university teaching hospital in the United Kingdom between January and February 2013. A list of commonly prescribed ENT medications in our department was drafted, and their constituents were confirmed with corresponding manufacturers.
Forty patients responded to the questionnaire in this period. Responses for the following questions were collected and results were analyzed: (1) Are you vegetarian? Religious/lifestyle choice/others; (2) Do you ask your doctor if he/she is prescribing medication containing animal products?; (3) If you are a vegetarian, would you take any prescribed medication containing animal products?; (4) Do you think a patient should be offered a vegetarian alternative if they prefer/choose?
We have found a significant proportion of our patients are vegetarian and that they prefer to have a choice of medications that are suitable for vegetarians if available. We have tabulated a list of commonly prescribed medicines in our department and contacted the relevant pharmaceutical companies, inquiring if their medicines contain any excipients from an animal source. Although the majority of medicines contained no animal-sourced active components or excipients, a significant proportion did. One of the most common excipients used was gelatine (E441).
Evaluate the association between lingual tonsil hypertrophy (LTH), gastroesophageal reflux disease (GERD), and laryngopharyngeal reflux (LPR).
A systematic literature search was performed using MEDLINE and the Cochrane Library databases through July 2013 to identify original research articles examining the effects of GERD or LPR on LTH in both adults and children. Only original research articles in English were retrieved using the keywords “reflux and lingual tonsil,” “reflux and base of tongue hypertrophy,” “laryngopharyngeal reflux and lingual tonsil,” “LPR and lingual tonsil,” and extraesophageal reflux and lingual tonsil.”
Out of 33 studies that matched the search criteria, 5 studies in adults and 3 studies in children met the inclusion criteria. In adults, one study noted a significantly increased prevalence of LTH in patients with signs and/or symptoms of LPR (62.4%) versus patients without signs and/or symptoms of LPR (29.3%). Four studies noted an increase in the severity of LTH in the presence of signs or symptoms of LPR. In the pediatric population, all 3 studies noted a positive association between the presence of LPR and GERD and the presence of LTH (30%-70%).
The results of this systematic review suggest an association between LTH and reflux in both adults and children. This study is limited by heterogeneity in methodology and definitions of LTH and reflux between included studies. Further investigation is needed to characterize the clinical entity of LTH as well as the nature of the relationship between LTH and reflux disease.
(1) Assess the current fund of knowledge about alternate airways (tracheostomy and laryngectomy) among practicing physicians, residents, and senior medical students at University of California, Davis. (2) Identify knowledge deficits regarding alternate airways. (3) Assess the need for improved medical education about care of alternate airways.
A cross-sectional survey study at an academic medical center. An anonymous 10-question, multiple-choice survey was administered to senior medical students as well as resident and attending physicians at the University of California, Davis in the departments of Emergency Medicine, Family Medicine, General Surgery, Internal Medicine, Otolaryngology, Pediatrics, and Physical Medicine & Rehabilitation. Scores from the physicians in the Department of Otolaryngology–Head and Neck Surgery were compared with nonotolaryngology physician and medical student scores. These data were analyzed using analysis of variance.
Otolaryngology physicians scored an average of 98%, while nonotolaryngology physicians scored 58% and medical students scored 64% (
Individuals with alternate airways (tracheotomies or laryngectomies) are common, and their care demands a fundamental understanding of and comfort with their unique provision. Our preliminary findings identify significant knowledge gaps among nonotolaryngologists concerning the critical topic of alternate airways. These deficits underscore the importance of improving familiarity with alternate airways among nonotolaryngologists who are likely to encounter such individuals.
The modified Glasgow prognostic score (mGPS) is known to reflect the degree of tumor-associated inflammation and cancer cachexia and is associated with survival in various malignancies. The prognostic value of mGPS in head and neck cancers remains unclear. The purpose of this study was to evaluate the prognostic potential of the mGPS in patients with advanced head and neck cancer.
Patients with advanced head and neck cancer treated at the University of Tsukuba Hospital between January 2002 and December 2011 were retrospectively evaluated. They were divided according to their mGPS. The mGPS was calculated based on the admission data as follows: patients with an elevated level of C-reactive protein (>1.0 mg/dL) and hypoabuminemia (<3.5 g/dL) were allocated a score of 2, patients with elevated C-reactive protein serum levels without hypoalbuminaemia were allocated a score of 1, and patients with neither of these abnormalities were allocated a score of 0. The utility of the mGPS as a prognostic indicator was evaluated.
A total of 210 patients enrolled. Patients with an mGPS of 0 had better overall survival and disease-free survival than did those with an mGPS of 1 or 2. Multivariate analysis revealed that the mGPS was a significant risk factor for overall survival and disease-free survival.
The results that patients with a raised mGPS had a significantly higher risk of death suggest that the mGPS is useful for predicting outcome in patients with advanced head and neck cancer and should be included in their routine clinical assessment.
(1) Describe the online electronic Work-Based Assessments (WBAs) tools (run by Intercollegiate Surgical Curriculum Programme [ISCP]) used by consultant trainers in surgical training in the United Kingdom. (2) Describe the current perceptions and prior training (TrACE-Training and Assessment in the Clinical Environment) received by consultant trainers of such training tool.
An anonymous electronic survey was circulated to all surgical educational supervisors within a large southeast England university teaching hospital in the period of August-December 2013.
Twenty-one consultants were identified. Seventeen responded (81%), all using WBAs in ISCP. Only 1 supervisor had heard of TrACE, and 17% had received no formal training in verifying themselves as competent in their assessor role. Thirty-five percent felt they would like to receive formal ISCP training, with the remainder happy to self-certify their competency.
The GMC specifies that trainers must be competent in the use of WBAs and the ISCP cites a need for systematic accreditation of supervisors. The RCSEng runs TrACE course, which explains roles/responsibilities of a trainer/supervisor with regard to the use of WBAs. Supplementary to the “Training the Trainers” course, it offers a structured forum to discuss recent changes in postgraduate training. We conducted this study to assess awareness/uptake/thought regarding changes in surgical supervision to identify whether the guidelines are being implemented. We recommend increased publicity for this and similar courses providing consultants for this training. The alternative is a more formal adoption of current status quo whereby consultants appointed as supervisors and assessors self-certify their competency in supervising juniors.
(1) Describe a combined sialendoscopic and transoral approach to remove large intraparenchymal submandibular sialoliths. (2) Assess functional results after stone removal.
Eighteen consecutive patients with large submandibular hilar stones with intraparenchymal extension were enrolled in this prospective study at the ENT University Unit of the “A. Fiorini” Hospital, “Sapienza” University of Rome, from April 2011 to June 2013. In all cases the size of sialoliths (median diameter 1.8 cm, range 0.9-2.2 cm) prevented sialendoscopic intraductal removal even after lithotripsy. The diagnosis was confirmed by ultrasound examination and, in selected cases, by computed tomography imaging. In all cases a combined sialendoscopic and transoral approach was accomplished by performing a deep incision of the mouth floor at the submandibular hilus level after endoscopic visualization of the stone. Three months after surgery an ultrasound examination was re-run to detect the presence of residual sialoliths. Pre- and intraoperative findings, surgical times, follow-up data, and functional results were analyzed.
Intraparenchymal stones were successfully removed using the combined technique in all cases. Fifteen patients (83.5%) were symptom-free after 6 months of follow-up. Two out of 3 still-symptomatic patients showed residual sialolithiasis at postoperative ultrasonography.
The outcomes of this preliminary study suggest that combined sialoendoscopic and transoral approach is an efficient technique for the removal of large intraparenchymal calculi, which may avoid resorting to sialoadenectomy and thus decrease risk of nerve damage or salivary fistulae.
Trismus is a symptom that impacts daily life activities and adversely affects patient health-related quality of life (HRQL). Radiation-induced fibrosis is probably one of the most important etiological factors to trismus in head and neck cancer (HNC). The aim of this randomized prospective study was to compare 2 different jaw exercise devices, regarding improvement in mouth opening (MIO) and patient-reported symptoms in HNC patients with trismus.
The 50 study patients were enrolled in a 10-week structured MIO training program and randomized to training with either TheraBite® device or Engström jaw device. The patients were regularly assessed by an oral surgeon and answered different questionnaires (ie, EORTC HN35 and the Gothenburg Trismus Questionnaire [GTQ])).
Both groups improved their MIO, 7.2 mm (22.9%) and 5.5 mm (17.6%) for TheraBite® and Engström, respectively. The largest increase in MIO was seen during the first 4 weeks of exercise. After the exercise periods 84% in the TheraBite® group (n = 21) and 60% in the Engström group (n = 15) no longer fulfilled the trismus criteria. A statistically significant improvement regarding trismus related symptoms in both groups with less pain, jaw-related problems, and eating limitations after the exercise period was found (
Structured intervention with a jaw exercise device improved the mouth opening capacity with less trismus-related symptoms in HNC patients. No statistically significant differences between the different devices were found. We suggest a feasible exercise program for radiation-induced trismus in HNC patients.
The objective of this study was to review consecutive tympanostomy tube surgeries for the past 8 years, paying particular attention to the type of tube inserted at the time of surgery.
Retrospective chart analysis of the last 3046 consecutive ears for tympanostomy tube surgery from 2005 to 2013.
Out of 3046 total ears reviewed, the total rate of otorrhea was 3.78% with 0.0% otorrhea in titanium tubes, 0.0% otorrhea in Sheehy activent tubes, 2.19% otorrhea in Donaldson tubes, 2.72% otorrhea in Sheehy collar button tubes, 3.28% otorrhea in Shepard tubes, 3.88% otorrhea in fluoroplastic tubes, 6.9% otorrhea in stainless steel tubes, 18.52% otorrhea in Goode tubes, and 25.0% otorrhea in triune tubes.
Early posttympanostomy tube otorrhea is a frequent complication of tympanostomy tube insertion with a complication rate of 3.8%, and the type of tubes placed at time of surgery seems to make a difference in the incidence of posttympanostomy otorrhea.
(1) Investigate whether treatment with an ultrasound probe can reduce the weight of salivary calculi in vitro. (2) Determine the effect of ultrasound application on chemolysis of salivary gland stones with diluted acetic acid.
Ten submandibular calculi (mean weight 159 ± 80.2 mg) were halved. After randomization these halves were each placed in a beaker containing saline solution (0.9%, pH5.3) or diluted acetic acid (0.6%, pH 2.78), respectively. An ultrasound probe (1-mm diameter, 30 kHz) was dipped into the solution with a tip-to-calculi distance of 5mm. Ultrasound was applied in a continuous mode for 3 hours. To determine the extent of dissolution, the calculi were weighed and photographed before and after the treatment.
The mean weight reduction of salivary calculi after ultrasound treatment was 2 ± 1.1 mg in isotonic saline solution and 19.1 ± 13.7 mg in diluted acetic acid, respectively. The differences were statistically significant (
A weight reduction of salivary calculi can be achieved by ultrasound application in vitro. Ultrasound treatment enhances the effect of chemolitholysis with diluted acetic acid. This could be helpful to diminish the size of salivary calculi within the scope of minimally invasive therapy of sialolithiasis.
Determine in subjects with hearing loss if speech discrimination declines over time and, if so, whether it could be maintained or restored with the use of hearing aids.
A prospective study of age-related hearing loss performed over 6 years concluding in February of 2013 in a private physician’s office. Subjects: 39 male, 44 female, mean age of 72 years, reporting difficulty hearing who agreed to have repeat audiometric evaluation at least 6 months following the initial audiogram, whether or not they obtained amplification. Subjects were given an initial hearing examination to measure tone threshold and speech discrimination. Forty-seven of the subjects received amplification shortly after this initial test and were tested a final time 27.7 months later. Twenty-five of the subjects did not receive amplification immediately after the initial test but did receive amplification after a second test (36 months later) and were then given a final test 19.5 months later. Eleven of the subjects never received amplification but were tested a final time 39.1 months after their initial hearing exam. Outcome measures: Tone threshold and speech discrimination.
Subjects who never received amplification showed significant loss in speech discrimination (
Progressive hearing loss is associated with a loss of speech discrimination. Speech discrimination can be maintained or restored by the use of hearing aids.
Evaluate a picture of narrow band imaging (NBI) examination for a diagnosis of laryngopharyngeal reflux disease (LPRD) using the image processing analysis objectively.
Ten patients who underwent NBI were studied. Eight patients were LPRD and 2 patients were non-LPRD patients. We performed image processing for pictures after NBI examination by using the application software of a perfect translation invariance complex discrete wavelet transform (PTI-CDWT) developed at Toyohashi University of Technology and MATLAB (The MathWorks, Inc.). We looked into the nasopharyngeal mucosa physical changes that were detected by PTI-CDWT and analyzed by MATLAB.
Images with LPRD showed many round opaque dots mostly consistent with round wavelet transform. On the contrary, images without LPRD represented a small number of linear lines, and any other area showed no feature. Morphologic operation by MATLAB distinguished the difference of nasopharyngeal mucosa physical exchange between LPRD and non-LPRD.
Though LPRD is a common disease for otolaryngologists to see, it may not yet be a definite diagnosis like gastroesophageal reflux disease. We have presented a correlation between LPRD and nasopharyngeal mucosa examination as mackerel cloud pattern at American Academy of Otolaryngology—Head and Neck Foundation annual meetings. We showed the possibility of image processing to diagnose LPRD with PTI-CDWT last year. Images which were implemented morphological operation by MATLAB may show representative for each nasopharyngeal mucosa physical change. MATLAB characterized images which were modified using PTI-CDWT. To use PTI-CDWT and MATLAB is not only useful in diagnosing LPRD but may possibly allow one to develop image diagnosis or an analysis instrument.
(1) Examine and analyze whether there are ethnic disparities in myringoplasty rates and outcomes in New Zealand.
Prospective cohort of 167 consecutive myringoplasty surgeries performed at the only public regional hospital in a district of New Zealand between 2003 and 2012. Basic patient demographics including ethnicity and nature of perforation (size, location, and active infection) were recorded preoperatively. Primary outcomes were of successful perforation repair on postoperative review, hearing improvement on pre- and postoperative audiograms, and prevention of recurrent infections of the middle ear.
In our cohort, the native Maori of New Zealand have disproportionately high incidences of myringoplasty surgery compared with the majority Europeans (28.7/100,000 vs 6.2/100,000 persons/year,
Our study supports the hypothesis that native Maori of New Zealand have a greater burden of middle ear disease compared with the majority Europeans but shows that Maori are just as likely to benefit from myringoplasty surgery. Further population-level studies are required to verify this.
Evaluate the effects of postoperative steroids compared with no steroids following tonsillectomy.
This study was a prospective double-blinded, randomized trial from April 2013 to September 2013. Forty patients age 5 years or older who were scheduled for elective tonsillectomy with or without adenoidectomy were enrolled. Patients were randomly assigned to receive a postoperative course of prednisolone powder or tablet over 7 days (dosage: 0.25 mg/kg/d). The primary outcomes of this study were comparing degree of postoperative pain using a validated pain scale and estimation of healing process based on the percentage of total area of reepithelization of tonsillar area. The second day outcomes were comparing bleeding rate, presence and severity of nausea and vomiting, returning to a normal diet, returning to normal daily activity, and sleep disturbance.
Mean ages were 23.55 (prednisolone group) and 25.25 (control group). Postoperative pain score showed no difference at day 1 and 14, but much less pain in the prednisolone group at day 7 (
Oral prednisolone may offer improvement in the recovery phase from tonsillectomy without serious complications.
(1) Investigate whether otolaryngology–head and neck surgery (OHNS) outpatients consult health-related online resources and establish baseline levels of perceived eHealth literacy. (2) Determine which resources patients use to investigate their disease and research treating physicians. (3) Explore relationships between perceived eHealth literacy, demographic data, and internet usage.
A questionnaire was administered to 79 patients in a tertiary care OHNS outpatient setting between December 2013 and February 2014. The questionnaire recorded (1) demographic data, (2) health-related Internet use, and (3) eHealth Literacy Scale (eHEALS), a tool used to measure perceived eHealth literacy.
Seventy-five of 79 patients completed the questionnaire. Seventy-six percent (n = 57) of patients had consulted online resources regarding their disease. The most commonly used resources were prompted by search engine results such as Google (88%, n = 51) and health websites such as WebMD (71%, n = 41). Only 14% of this group used the American Academy of Otolaryngology—Head and Neck website. Fifty percent (n = 38) of patients consulted online resources regarding their otolaryngologist prior to their visit. The mean eHEALS score was 3.65/5.0 (95% confidence interval [CI], 3.46-3.84). For patients who search for health-related information online, the odds of using dedicated health websites were 90.8% lower for patients with an eHEALS score below the mean versus above the mean (
The majority of patients in this study consulted online resources to learn about their disease and physician. In this cohort, the perceived eHealth literacy influenced the type of website consulted. Patients with lower perceived eHealth literacy were less likely to consult dedicated health websites.
(1) Compare the postoperative recovery of patients undergoing intracapsular tonsillectomy to subcapsular tonsillectomy for keratosis pharyngeous. (2) Determine the surgical efficacy of intracapsular tonsillectomy in preventing recurrent symptoms in patients with keratosis pharyngis.
A prospective, single-blinded, randomized controlled trial of adult patients ages 18 years or older diagnosed with keratosis pharyngis between December 2010 and February 2013 was performed. Patients were randomized to receive either intracapsular or subcapsular tonsillectomy with the coblator. Postoperative pain scores and amount of pain medication taken were recorded daily for 2 weeks postoperatively. A 6-month follow-up questionnaire was used to assess the efficacy of the procedure based on persistent symptoms.
Twenty-two patients completed the study, with 11 in each group. There was a statistically significant difference in the amount of pain medication consumed on postoperative days 8, 9, and 10, with the intracapsular group consuming less medication (
In adult patients undergoing tonsillectomy for keratosis pharyngis, an intracapsular, coblation tonsillectomy resulted in lower consumption of pain medication than subcapsular tonsillectomy. However, intracapsular coblation tonsillectomy resulted in a higher rate of recurrence of tonsilloliths. The benefit of decreased pain medication usage in the intracapsular cohort may be offset by the increased likelihood that symptoms will recur.
Assess the long-term outcomes of treating middle ear cholesteatoma with multiple techniques including intact-canal wall and scute repairing techniques.
One hundred thirteen patients had been treated between 2001 and 2006. Multiple techniques including harvesting bone chips with air drill, sculpting of autologous bone grafts, chorda tympani nerve tightening prosthesis, preventing adhesion with hyaluronic acid ester membrane, lesion cleaning, reconstruction of ear canal wall, re-gasification of attic and/or mastoid cavity, and early catheterization of the Eustachian tube were performed.
One hundred twelve ears only received the operation once, and the preoperative air bone conduction gap (ABG) was 33.61 ± 12.35 dB, which was significantly higher than postoperative ABG (13.58 ± 9.27 Db,
Treating middle ear cholesteatoma with intact-canal wall and scute repairing techniques is safe. These surgical procedures involve low relapse rate, and treating patients with relapsed cholesteatoma with these procedures could also result in good outcomes.
Nasal obstruction is known to be associated with a major decrease in disease-specific quality of life, and nasal valve dysfunction can play a considerable role in nasal airflow obstruction. There are many procedures for treating this type of nasal obstruction. Aim: Evaluate the efficiency of minimally invasive valve repair for the treatment of nasal obstruction due to nasal valve stenosis in comparison with the reduction of the size of inferior turbinate by coblation and sub mucosal diathermy (SMD).
This is a cross sectional study conducted atl–erbil from November 20, 2011, to September 19, 2013. The study included 43 patients suffering from nasal obstruction for more than 6 months. The patients were divided into 3 groups according to the type of surgery carried out (minimally invasive valve repair, coblation and submucosal diathermy [SMD] of inferior turbinate). Patients were followed for 3 months, and the data were statistically analyzed.
Patients showed highly significant differences between pre- and 1st, 30th, and 90th days postoperative total nose scale scores (
Minimal invasive valve repair had more rapid improvement and less postoperative morbidity in comparison with coblation and SMD of inferior turbinate.
(1) Identify the most common bacteria in odontogenic oral abscesses over the past decade. (2) Identify the prevalence of antibiotic resistance of pathogens responsible for odontogenic oral abscesses to guide initial antibiotic treatment.
This is a retrospective chart review conducted at a single tertiary academic medical center of adult and pediatric patients who underwent drainage of oral abscesses caused by odontogenic sources (n = 129), during which cultures of the abscess were obtained. The cultures were analyzed for type of pathogen and antibiotic sensitivities. Medical comorbidities and drainage techniques were reviewed.
Multiple bacteria species were identified in 59.69% of odontogenic abscesses and single bacteria species in 34.11%. The most common bacteria were alpha hemolytic streptococci (34.11%), streptococcus milleri (32.56%), prevotella strains (19.38%), and coagulase negative staphylococcus (14.73%). Clindamycin resistance was identified in stomatococcus (50%), lactobacillus (33.33%), streptococcus milleri (33.33%), staphylococcus (10%), corynebacterium (8.33%), and alpha hemolytic streptococcus (2.27%). Penicillin resistance was identified in stomatococcus (50%) and lactobacillus (33.33%). Methicillin resistance was identified in staphylococcus (10%). Erythromycin resistance was identified in streptococcus milleri (35.71%), staphylococcus (10%), corynebacterium (8.33%), and alpha hemolytic streptococcus (2.27%). Strepto-coccus milleri was also resistant to tetracycline (2.38%), and morganella morganii was resistant to ampicillin (100%) and cefazolin (100%).
Most oral odontogenic abscesses were polymicrobial, with the most common pathogens being alpha hemolytic streptococcus, streptococcus milleri, prevotella, and coagulase negative staphylococcus. The most common antibiotic resistances were to clindamycin and erythromycin, which should be considered when deciding initial antibiotic therapy.
(1) Identify the most common bacteria in peritonsillar abscesses over the past decade. (2) Identify the prevalence of antibiotic resistance of pathogens responsible for peritonsillar abscesses to guide initial antibiotic treatment.
This is a retrospective chart review looking at adult and pediatric patients who presented to a single tertiary academic center in upstate New York from 2002 through 2012 and underwent either incision and drainage or quincy tonsillectomy for a peritonsillar abscess (n = 69), during which cultures of the abscess were obtained. Cultures from the abscess were reviewed for bacteria and antibiotic sensitivities. Patient medical records were reviewed for age, medical comorbidities, prior episodes, immune-compromised state, type of drainage procedure done and complications, and whether more than one procedure was needed.
Of the peritonsillar abscesses, 62.32% were polymicrobial and 34.78% were monomicrobial. The most common pathogens were beta hemolytic streptococcus (31.88%), alpha hemolytic streptococcus (21.74%),
Peritonsillar abscesses are most commonly polymicrobial, with beta and alpha hemolytic streptococci,
Myringotomy and ventilation tube insertion is a common otolaryngologic surgical procedure with a steep learning curve for residents. Incorrect placement of incisions and external ear canal trauma are common complications when residents begin learning the procedure. With increasingly conservative guidelines on indications of myringotomy tubes, residents have less opportunities to refine this skill on real patients. The objective is to create a learner-centric myringotomy simulator.
Although the concept of simulation training in myringotomy is not new, we aim to reduce the learning curve by introducing learner-guided features on a simulation model. Some of these include landmarks such as the handle of malleus, the anterior inferior quadrant guide, and modified instruments as part of the simulation. Working with the National University of Singapore, Division of Industrial Design team, a 3-dimensional library of different variants of ear models, including modified ear canals for teaching, was created. We created a platform to house the different components including an auricle, an external ear canal, and a disposable tympanic membrane with landmarks.
The model is accurate with realistic consistency to mimic soft tissues encountered in the myringotomy procedure. The simulator allows for variance in anatomy between the side of the ear and also between adult and pediatric sizes.
Our model can be used to train otolaryngology residents and will be employed as a proof-of-concept model for the purpose of simulation training.
Compare facial function at onset of skilled facial rehabilitation of patients with facial paresis performing unsupervised facial exercise routine and patients with no previous intervention.
Retrospective chart review at a tertiary referral center including all patients from our institution who had >1/6 House Brackman score and were referred to physical therapy for facial retraining from 2012 to 2013. Patients were excluded from the study if they had a facial reanimation procedure or electrical stimulation prior to onset of physical therapy. The study used House Brackman (HB) and Facial Grading System (FGS) with 3 subscales: resting symmetry (rFGS), voluntary movement (mFGS), and synkinesis (sFGS).
Fourteen patients were referred to facial retraining therapy and met the specified inclusion and exclusion criteria. The medical diagnoses included postoperative acoustic neuroma resection, Bell’s palsy, and Ramsay Hunt Syndrome. Eight patients did not participate in exercise prior to physical therapy evaluation and 6 patients were issued unsupervised facial exercise prior to therapy. Patients who participated in an unsupervised facial exercise program had a significantly higher sFGS score of 6.83 ± 2.23 at initial physical therapy evaluation than those who did not participate in exercises, with a score of 3.75 ± 2.61 (
Patients who participated in unsupervised facial exercises had more synkinesis than those patients who did not. Generic facial exercises prior to formal individualized facial retraining therapy may be counterproductive. Further investigation is necessary to determine if initial synkinesis score impacts overall patient outcomes following intervention.
(1) Describe national trends in peritonsillar abscess (PTA) requiring endotracheal intubation (ETI). (2) Determine factors associated with ETI in patients with PTA.
Years 2003 to 2010 of the Nationwide Inpatient Sample (Healthcare Cost and Utilization Project, Agency for Healthcare Research and Quality) were queried for PTA (ICD-9 code: 475) and ETI (ICD-9 code: 96.04) in adult patients (age ≥18 years old). Descriptive statistics and multivariate regression modeling were employed to identify factors associated with ETI.
From 2003 to 2010, 90,941 (95% CI:86, 433-95, 449) admissions associated with a PTA were identified, of which 1357 (1.5%) underwent ETI. These patients had a higher prevalence of concurrently coded sepsis (7.3% vs 1.2%), severe sepsis (13.0% vs 0.2%), and death (7.9% vs 0.1%) compared with patients without ETI. Intubated patients were significantly (all
Patients with PTA undergoing ETI have worse in-hospital outcomes along with higher hospital charges. This study identifies characteristics of a PTA patient in whom clinicians should be wary of respiratory decompensation.
There has been recent controversy with regard to optimal postoperative pain control for tonsillectomy. Codeine is no longer recommended for children under the age of 12 years because of the risk of respiratory depression. Hence, identifying alternative/adjunct analgesia for post-tonsillectomy pain is a high clinical priority. This is a protocol for a randomized controlled trial. The primary objective is to determine whether GeloRevoice throat lozenges (contain sodium hyaluronate) are effective as adjunct therapy to standard analgesia (paracetamol, ibuprofen, difflam spray) in post-tonsillectomy pain.
A total of 72 patients were randomized to 2 groups. Parents with children aged 6 to 18 years undergoing tonsillectomy were approached to participate in the study. The intervention group received GeloRevoice throat lozenges and the control group received a placebo. The study was subject to trust research and audit and safety reporting procedures, and ethical approval was applied for.
The primary endpoint was a pain score using a visual analog scale for pediatric populations. Pain scores were recorded on a diary card daily for 1 week postoperatively. Visual analog scale data were compared between 2 groups using a 2-tailed
This double-blinded randomized controlled trial provides evidence on the safety and efficacy of GeloRevoice throat lozenges when used as adjunctive analgesia for post-tonsillectomy pain.
(1) Assess the readability of online tracheostomy care resources. (2) Compare the readability of major versus minor websites and patient- versus professional-oriented resources.
A Google search was performed for “Tracheostomy care” in January 2014. The top fifty results were categorized into major versus minor websites, and patient- versus professional-oriented resources. These websites were evaluated with the following readability tools: Flesch Reading Ease Score (FRES), Flesch-Kincaid Grade Level (FKGL), Simple Measure of Gobbledygook (SMOG), and Gunning Frequency of Gobbledygook (GFOG).
Readability scores for the 50 websites were FRES 57.21 ± 16.71 (possible range = 0 to 100), FKGL 8.33 ± 2.84 (possible range = 3 to 12), SMOG 11.25 ± 2.49 (possible range = 3 to 19), and GFOG 11.43 ± 4.07 (possible range = 3 to 19). There was no significant difference in all 4 readability scores between major (n = 41) and minor (n = 9) websites. Professional-oriented websites (n = 19) had the following readability scores: FRES 40.77 ± 11.69, FKGL 10.93 ± 2.48, SMOG 13.29 ± 2.32, and GFOG 14.91 ± 3.98. Patient-oriented websites (n = 31) had the following readability scores: FRES 67.29 ± 9.91, FKGL 6.73 ± 1.61, SMOG 10.01 ± 1.64, and GFOG scores 9.30 ± 2.27. Professional-oriented websites had more difficult readability scores than patient-oriented websites for FRES (
Online tracheostomy care resources were written at a level more difficult than the recommended fourth- to sixth-grade level for written health information. There was no significant difference in readability between major and minor websites. Professional-oriented websites were more difficult to read than patient-oriented websites.
(1) Determine the prevalence and common types of aerodigestive foreign bodies. (2) Determine the nonclinical factors that influence their occurrence among children under 12 years of age.
A case control study between February and October 2012. The study population was all children between 6 months and 12 years old presenting to the ENT clinic at Mbarara Regional Referral Hospital. Consecutive and random sampling was used for cases and controls respectively. The cases were recruited after removal of the foreign body in theater. Information collected included biodata, circumstances surrounding the occurrence of the foreign body, the type of foreign body, and the family’s socioeconomic status.
Prevalence was 6.6% with M:F = 2:1. The most common foreign bodies were seeds in the airway and coins in the esophagus. There was a strong association between the type of foreign body and activity of the child at the time of the incident (
The prevalence of aerodigestive foreign bodies is relatively high. Risk factors include age under 5 years, male sex, the child’s activity at the time, and younger age of the mother. A higher socioeconomic status and female sex are protective. Therefore nonclinical factors influence the occurrence of aerodigestive foreign bodies among children.
(1) Describe robot-assisted sialolithotomy with sialoendoscopy (RASS) for the management of large submandibular gland (SMG) stones. (2) Analyze symptom recurrence and lingual nerve damage following RASS in comparison to the combined transoral sialoendoscopic approach (CTA).
A retrospective case series was performed on patients with large palpable SMG stones managed with RASS. Large stones were defined as >4 mm, the upper limit that can be removed via sialoendoscopy. Fourteen patients who presented between October 2012 and January 2014 with mean stone size of 11.9 mm were identified. Patients were questioned regarding symptom recurrence, symptoms of lingual nerve damage, and procedural satisfaction at mean follow-up of 8 months. Procedural success was defined as absence of symptom recurrence in conjunction with gland preservation. These measures were compared to reported outcomes with CTA in the English literature.
Procedural success was 100% (14/14) for our series. No patients reported symptoms of lingual nerve damage at the time of follow-up, while 2 patients reported transient lingual nerve paresthesia (mean duration 2.5 weeks). Mean patient satisfaction was 9.8 on a scale of 10. Literature review identified 137 patients who underwent CTA for large SMG stones between 2005-2011. Procedural success rate for these patients was 75%. When commented on, lingual nerve damage was reported in 2% of patients.
Preliminary data in management of large SMG stones with RASS shows improved procedural success in comparison to CTA. Furthermore, the morbidity of lingual nerve damage seen in CTA has yet to be encountered with RASS, likely due to improved visualization.
In Sweden, tonsillotomy has for a decade been the favored surgical method for reducing airway obstruction from enlarged tonsils. Less postoperative morbidity with comparative symptom relief are the advantages seen. The concern has been raised that tonsillotomy increases risk of secondary tonsil surgery compared with tonsillectomy. The study aimed to evaluate the risk of secondary tonsil surgery following tonsillotomy and tonsillectomy in the Swedish population.
This is a retrospective register-study including all patients registered in the National Patient Register from 2000 until 2012 who underwent tonsil surgery. Personal identity numbers make it possible to follow patients over time in the register. All patients who underwent tonsillectomy and tonsillotomy, with or without simultaneous adenoidectomy, without previous history of tonsil surgery were included in the study. Individual information on demographic data, diagnoses, and surgery performed were recorded.
A total of 120,719 tonsil surgeries were identified, out of which 98,717 were tonsillectomies and 22,002 were tonsillotomies. A total of 1409 events of revision surgery were identified of which 40.3% were after primary tonsillectomy and 59.7% were after primary tonsillotomy. Tonsillotomy showed a 7-times higher risk of secondary tonsil surgery. The accumulated risks of secondary tonsil surgery after 5 and 10 years in the tonsillectomy group were 0.6% and 0.8%, respectively. In the tonsillotomy group, the accumulated risks were 6.1% and 7.2%, respectively.
The risk of secondary tonsil surgery in the Swedish population is 7 times higher after tonsillotomy compared with tonsillectomy. When interpreting this result the differences in postoperative morbidity between tonsillotomy and tonsillectomy must be considered.
During the past decade, oral cancer has become the fourth cause of death in Taiwan. After receiving treatment at the early stages of oral cancer (stage I and stage II), the 5-year survival rate is up to 81.9%. However, as soon as cancer cells spread to the neighboring tissues accompanied with lymph node metastasis in the neck (stage III and stage IV), the 5-year survival rate drops to 23-25%. This indicates the importance of the early detection of carcinogenesis to high survival rate. Aberrant methylation in promoter regions of certain genes has long been noticed and evidenced as strongly correlative to carcinogenesis.
The tissue samples were obtained from the patients of one medical center, and the tissue was divided into 3 parts: tumor, nearby tissue, and further (normal) tissue. Then, the tissue was deposited in liquid nitrogen for DNA and RNA extractions. Patient data were collected including age, sex, risk factors (alcohol/betelnut/cigarette use), clinical and pathological stage, and operation.
This study investigates the aberrant methylation level on seven genes, E-cadherin, cyclinA1, cytoglobin, IGF2, MGMT, P16, and RARβ, in tissue samples of oral cancer.
By means of the high sensitivity and accuracy technology, pyrosequencing, the methylation profiles of studied genes should be able to provide insight and evaluation of biomarkers of aberrant methylation in carcinogenesis.
Determine the progression of flexible transnasal laryngoscopy reliability and competency in otolaryngology residency training.
Prospective study of flexible transnasal laryngoscopy interpretations. Seventeen otolaryngology residents from PGY-1 to PGY-5 and 3 attending otolaryngologists viewed 25 selected and digitally-recorded flexible transnasal laryngoscopies. The evaluators were asked to rate 13 items relating to abnormalities in the oropharynx, hypopharynx, larynx, and subglottis. The level of concern and level of comfort with the diagnosis were assessed. Intraclass correlations were calculated for each topic and by level of training to determine reliability within each class, and competency compared to attending interpretations.
Intraclass correlation of residents compared with attending physicians demonstrated significant improvements by year for left vocal fold immobility (ICC 0.85-0.96), right vocal cord immobility (ICC 0.80-0.97), subglottic stenosis (ICC 0.70-0.97), and level of concern (ICC 0.72-0.87). There were no trends for base of tongue abnormalities, pharyngeal abnormalities, pharyngeal masses, and hypopharyngeal masses. For vocal cord immobility, subglottic stenosis, and level of concern, resident reliability was found to be statistically similar to attending physicians in all categories by PGY-3.
Resident competency for flexible transnasal laryngoscopy progresses during residency to reliability with attending otolaryngologists by PGY-3 over key facets of the examination. Flexible laryngoscopy may be a useful metric for procedural competency assessment during residency training.
Burning mouth syndrome (BMS) is characterized as a burning sensation in the mouth without definite oral pathology. Although BMS is not uncommon, the etiology and psychological profiles are not well established. The aim of this study is to evaluate the role of psychological factors in BMS patients.
We prospectively compared the psychiatric symptoms using Symptom Checklist-90-Revised questionnaire (SCL-90-R) in 50 patients diagnosed with BMS and 52 controls who had no oral and pharyngeal disease from December 2012 to June 2013.
The mean age (56.8 vs 52.8 years,
Based on the results of this study, it is suggested that psychosomatic factors may contribute to the development of BMS.
This study aims to introduce a device, which has been widely used to train the personnel recruited for naval missions in frigates, used as a motion sickness detector in our study. We also compared the findings of the motion sickness patients to the normal population.
Thirty adult male personnel were included. Sea intensity between level 1 and level 5 was simulated, and the parasympathetic and physical findings of the personnel were recorded.
The mean age was 22.6 ± 3.4. During level 2 intensity, 4 personnel (13.33%); level 3, 5 personnel (16.66%); level 4, 12 personnel (40%); and level 5, 9 personnel (30%) demonstrated motion sickness symptoms.
Besides training purposes, these simulators could be helpful to identify motion sickness disease in the targeted personnel before naval missions.
Describe how tonsil surgery was performed in Sweden 2013.
The National Tonsil Surgery Register in Sweden collects detailed information regarding indication, surgery, and complications for tonsil operations. The purpose of the register is primarily to provide a basis for the description of a clinic and stimulate quality improvement programs. Also, the data can be used for research. All clinics are encouraged to include all tonsil surgeries in Sweden in the register, and during 2013, over 80% of all tonsil surgeries are estimated to be included. Information registered through questionnaires is data regarding indication, surgery performed, and complications such as readmission or return to theater due to bleeding.
A total of 11,029 tonsil surgeries were registered in 2013. Surgical methods used were tonsillectomy (4726), tonsillectomy with adenoidectomy (1632), tonsillotomy (738), and tonsillotomy with adenoidectomy (3933). Tonsillectomy was mainly used for infectious indications while tonsillotomy was used for obstructive/sleep apnea indications. Tonsillectomy was performed with cold knife (3056) or diathermy scissor (1217). Tonsillotomy was performed with coblation (653). Primary bleeding was registered in 1.8% of the total cohort. Readmission due to secondary bleeding was registered in 5.9% of the total cohort, but 11.4% after tonsillectomy and 2.2% after tonsillotomy. Return to theater because of bleeding was registered in 2.1%.
Detailed information regarding tonsil surgery can be assessed with the National Tonsil Surgery Register in Sweden. Data can be used for studies on a large population and provide new knowledge.
Assess the 2008-2012 American and Canadian contribution to the world otolaryngology literature.
All articles published from January 2008 to December 2012 in 8 otolaryngology journals were reviewed. Book reviews, letters, correspondence, and meeting abstracts were excluded. Nationality, author numbers, and study types were extracted. Nationality of the article was defined by the publishing department’s country of origin. Articles were categorized into primary clinical research, primary basic science research, secondary research such as systematic reviews and meta-analyses, and other articles that did not fit the aforementioned classifications. Articles originating from the United States, Canada, and the rest of the world were statistically compared using Mantel-Haenszel Common Odds Ratio Estimate, Pearsons chi-squared, and Fisher exact tests.
A total of 3635 articles published in the journals surveyed were analyzed. Canadian-authored papers decreased from 12.8% in 2008-2009 to 10.2% in 2011-2012, whereas American-authored papers increased from 27.9% in 2008-2009 to 30.1% in 2011-2012. These changes were statistically significant (
There were significant changes in otolaryngology publishing trends in the United States and Canada. Increase in multiauthorship in Canadian-authored papers possibly suggests increased collaboration with multi-disciplines and decreased investigator productivity.
(1) Review our experience with trans-oral excision of the submandibular gland. (2) Compare outcomes of the transoral approach with the traditional transcervical approach.
A retrospective chart review of prospectively collected data. Forty-three patients with benign submandibular gland pathology who underwent trans-oral excision of the submandibular gland from 2007-2013 were identified. Data pertaining to patient demographics, conversion to open approach, recurrence of disease, length of operative procedure, length of hospital stay, and incidence of neurologic complications were collected.
Forty-three patients underwent transoral excision of the submandibular gland over a 6-year period. Of the 43 procedures performed, 1 transoral case required conversion to an open procedure, and therefore 98.6% of patients avoided a neck scar. Thirty-four out of 42 (80%) of patients reported transient tongue parasthesias. No patient experienced hypoglossal or facial nerve dysfunction.
Transoral submandibular gland excision is a safe and effective procedure. The approach allows for avoidance of an unsightly neck scar as well as lower rates of injury to the lingual, hypoglossal, and facial nerves when compared to a transcervical operation. This should become a routine part of the surgical armamentarium of the well-trained otolaryngologist.
Observe the applied value of epiglottis in laryngeal function reconstruction after partial laryngectomy.
From April 1997 to December 2008, there were 295 patients with laryngeal carcinomas who were operated on in our department. There were 40 patients who had partial laryngectomy and laryngeal function was reconstructed using epiglottis with or without other materials. The 40 cases were followed up and the oncologic and functional results were retrospectively analyzed. We calculated the 3- and 5-year tumor-free survival rates and evaluated the rehabilitation of laryngeal function.
The 3- and 5-year tumor-free survival rates were 82.9% and 75.7%, respectively. All of the patients with supraglottic carcinoma had tumor-free survival; in the 3 patients with subglottic carcinomas, only 1 patient had tumor-free survival for 5 years; in the 34 patients with glottic carcinomas, 6 patients died, and 1 patient with local recurrence had a total laryngectomy. The total decannulation rate was 90%. Thirty-nine patients rehabilitated normal peroral feeding. The mean time of removal of the nasogastric tube was 15.7 days. In the 40 cases, voice quality was good in 6 patients with a little hoarseness, 2 were worse, having only a whispered voice, and the others were moderate; the rate of vocal satisfaction was 95%.
Using the epiglottis with or without other materials to reconstruct laryngeal function after partial laryngectomy is a useful alternative to total laryngectomy in laryngeal cancers, especially in selected advanced cases which improve the quality of life. The epiglottis is one of the ideal materials in laryngoplasty after partial laryngectomy.
Pharyngeal fistula is the most common and troublesome postoperative complication after surgery of larynx, lower pharynx, and cervical esophagus carcinoma. This study aims to identify (1) the potential predisposing factors of pharyngeal fistula in laryngeal carcinoma patients after laryngectomy and (2) how nutritional support during treatment would contribute to improve prognosis.
Retrospective review of 156 consecutive cases of laryngeal carcinoma patients who underwent laryngectomy from 2011 to 2013 at China-Japan Union Hospital, Jilin University. Nutritional support and other potential predisposing factors were analyzed between patients with and without pharyngeal fistula.
Among the 156 cases studied, 6.4% of patients demonstrated postoperative pharyngeal fistula. Many predisposing factors showed statistical significance (
The occurrence of pharyngeal fistula in laryngeal carcinoma patients is highly associated with the duration of smoking, neck dissection, duration of operation, postoperative serum albumin/total protein level, and body weight change. By optimizing the patients’ general preoperation conditions and synchronous nutritional support, it would largely enhance the therapeutic response, reduce incidence, and improve prognosis.
(1) Present the application of 4-dimensional (4D) computed tomography (CT) in preoperative localization of parathyroid adenomas that do not localize with technetium-99 (Tc-99) single-photon emission computed tomography (SPECT)/CT or ultrasound. (2) Present indications for 4D-CT use. (3) Understand radiologic dosimetry issues of 4D-CT.
A retrospective review of over 15 consecutive patients at an academic medical center with primary hyperparathyroidism who underwent preoperative 4D-CT after nonlocalizing preoperative ultrasound and Tc-99 SPECT-CT scans between November 2013 and June 2014. This was a mixture of patients presenting for their first operations and others requiring revision surgery. Intraoperative radioguided parathyroidectomy results, excised gland weight, patient demographics, and parathyroid hormone levels were recorded. Sensitivity, specificity, and positive and negative predictive values of 4D-CT for preoperative adenoma localization were calculated.
4D-CT resulted in successful localization and biochemical cure in all primary or revision cases in which it was utilized. Radiation doses from 4D-CT will be presented and compared to radiologic dosimetry from SPECT-CT.
4D-CT offers a sensitive and specific modality for preoperative parathyroid adenoma localization which is useful in cases where ultrasound and SPECT-CT sestamibi are nonlocalizing.
Use 3-dimensional volumetric analysis of postoperative computed tomography (CT) scans to characterize tongue volume and correlate measured values with swallowing function.
Retrospective chart review of prospectively collected data. Fifteen patients treated with surgical resection and free flap reconstruction of the oral and base of tongue with or without postoperative irradiation between 2010 to 2012 were included in the study. Mimics program was used to obtain measurements of the oral tongue and tongue base volume, tongue base to oropharyngeal volume ratio, and tongue base to posterior pharyngeal wall distance by analyzing the postoperative 6-month and 1-year CT scans. Prospectively collected functional outcomes data, including aspiration/penetration score, perceptual evaluation of intelligibility, and G-tube dependence rates, were evaluated and correlated with dimensional analysis measures.
Adequate but not excessive tongue base volume correlated with reduced aspiration/penetration score and improved speech intelligibility. Oral tongue volume did not correlate with functional outcomes. Overall G-tube dependence rate was low in this cohort (13.3%).
Three-dimensional analysis of tongue volume can be used to help predict postoperative swallowing outcomes.
Improve the standard of care for patients undergoing thyroid surgery. Recognized complications include hypocalcemia and recurrent laryngeal nerve (RLN) damage. We aimed to review our practice and improve it by adhering to the criteria set out by the National Institute of Clinical Excellence (NICE).
Retrospective audit looking at patients undergoing thyroid surgery over a 6-month period (09/2012). Pro forma methods were used to establish the adequacy of documentation including the use of nerve monitoring equipment, identification and stimulation of the RLN, and the recording of pre- and postoperative vocal cord checks (n = 18). Retrospective re-audit after recommendations to complete the loop (n = 8) over a 4-month period.
The first part of the audit cycle identified haphazard management of calcium levels in the postoperative period, incomplete documentation of vocal cord checks, and RLN identification and testing during surgery. Recommendations and guidance to staff, as well as a revised protocol on calcium management, resulted in improved care overall following re-audit. In part 2 of the audit cycle; only 1 patient became hypocalcemic in the postoperative period and was managed successfully following the protocol. RLN detection, testing, and monitoring were documented in all patients. The 2nd loop showed that all patients were receiving documented RLN identification and stimulation intraoperatively; all patients had documented pre- and postoperative cord checks and use of a nerve monitor (n=10).
The audit shows we were able to meet the criteria set out by NICE.
(1) Describe the radiologic findings of arrested pneumatization of the sphenoid sinus. (2) Recognize this benign developmental variant to prevent unnecessary surgical intervention.
A case series. Between November 2012 to January 2014, 8 subjects presented with radiologic findings consistent with arrested pneumatization of the sphenoid bone, a benign developmental variant. In each case, review of imaging by a neuroradiologist confirmed this diagnosis using strict criteria. This series includes all cases encountered during routine clinical practice during this time period. Charts were reviewed for demographic, clinical, and radiologic data.
In all 8 cases, arrested pneumatization of the sphenoid sinus was an incidental finding. All subjects underwent computed tomography (CT) imaging as workup for a variety of otolaryngology-related symptoms, including headache, hearing loss, facial trauma, and sinusitis. Two patients were referred after the finding of a sphenoid lesion was mistaken for a pathologic entity. Based on CT imaging, 7 subjects were recognized as having this benign developmental variant and were managed conservatively. One patient, whose imaging revealed what appeared to be an infiltrative, midline tumor of the sphenoid sinus, underwent surgical biopsy with benign results. Upon subsequent review of CT imaging at our institution, the lesion did appear to have features consistent with arrested pneumatization.
Considering the frequency of identification of arrested pneumatization of the sphenoid, there is a paucity of information about this diagnosis within the otolaryngology literature. Familiarity with this entity may prevent additional costly workup or unnecessary surgical intervention.
(1) Measure axial and coronal parapharyngeal space area (PPSA) and parapharyngeal mucosal thickness (PMT) in patients who present with cancer of unknown primary (CUP). (2) Determine if PPSA and PMT differences between affected and unaffected sides of the oropharynx were found based on site of primary (tonsil vs base of tongue [BOT]) or body mass index (BMI).
Institutional review board–approved retrospective chart and preoperative computed tomography (CT) review of consecutive patients presenting between 2007-2013 with CUP to a tertiary university hospital. Subjects did not have an identified primary on clinical or imaging examinations including positron emission tomography/CT but did have an identified primary after surgery. Two blinded radiologists reviewed CT scans. Measurements of PPSA and PMT at defined levels in the axial and coronal planes and prediction of the primary site were made. Independent variables were primary tumor site and BMI. Comparisons were made using Student
There was no significant difference in PPSA or PMT between the affected and unaffected sides of the oropharynx for the entire group (n = 17, ΔPPSA axial 0 mm2,
Differences in axial PPSA and PMT were not useful to predict the primary site in patients with CUP. Although not statistically significant, coronal PPSA in subjects with BMI >25 may be useful in identifying the primary tumor site.
Systematically evaluate the diagnosis, treatment, and outcomes of globally published cases of cervical sympathetic chain schwannomas (CSCS) to guide clinical decision making.
Using Medline, EMBASE, and Cochrane databases, 89 CSCS case reports/series were identified from 1997 to 2013. Most cases were treated internationally (82%), predominantly in Asia (50%) and Europe (27%). Demographic, clinical, and outcomes data were extracted by 2 independent reviewers with high interrater reliability (k = 0.79).
On average, patients were 42.6 years old (SD = 13.3) and had a 2 to 4-cm (52.7%) or >4-cm (43.2%) neck mass. Nearly 70% of cases were asymptomatic. Presurgical diagnosis relied heavily on computed tomography (63.4%), magnetic resonance imaging (MRI; 59.8%), or both (20%), supplemented by cytology (47.6%). US-treated cases were significantly more likely to receive pre-surgical MRI than internationally treated cases, but less likely to have cytology or histopathology (
Given the typical CSCS patient is young and asymptomatic, presurgical diagnostic accuracy is very low, and the likelihood of persistent postsurgical morbidity is high with aggressive extracapsular surgery, less invasive approaches to differentially manage CSCS are warranted.
Describe our results about the clinical significance of salivary CD44sol levels in laryngeal carcinomas and analyze its emerging role as a diagnostic and prognostic factor.
The study design was prospective. Patients with laryngeal cancer were selected and recruited at the Division of Otolaryngology, University of Catanzaro, from January to December 2012. Patients with benign head and neck disease were also included as a control group. For each patient, clinical-anamnestic data were collected in a database. The data were recorded relating to any disease recurrence and locoregional or distant metastases detected during the follow-up, every 3 months. The sampling of undiluted saliva was performed the day before surgery and during the follow-up, every 3 months. Salivary CD44sol levels were determined using the enzyme-linked immunosorbent assay method.
In patients with laryngeal carcinoma, salivary CD44sol levels were significantly higher than those in the control group (
In a previous study, we demonstrated that CD44sol can be an effective biological marker with useful application for early detection and screening in laryngeal cancer. The analysis of the obtained data shows that the Elisa CD44sol determination can represent a promising prognostic test.
Middle ear cancer is a rare condition with limited data regarding incidence and outcomes. We used the National Cancer Data Base (NCDB) to describe the patient characteristics, treatment patterns, and outcomes of these uncommon malignancies.
A total of 458 cancers coded as having the middle ear as their primary site were selected from the NCDB between 1998 and 2011 and analyzed using chi-square tests and Cox regression.
Median age at diagnosis was 64 years (range, 18-90 years) and most patients were white (79.7%). Histologic subtypes included squamous cell carcinoma (57.8%), adenocarcinoma (12.7%), other carcinoma (15.3%), and non-carcinoma (14.2%). Of the 209 patients with documented tumor extension, 38.8%, 55.5%, and 5.7% had local, regional, and distant disease, respectively. Treatment included surgery alone (41.3%), surgery and adjuvant therapy (40.9%), and nonsurgical therapy alone (17.8%). In patients from 1998-2006 with local and regional disease, the 5-year survival rates were 52%, 27%, and 22% for these treatment groups, respectively. After risk-adjustment, surgery alone had better survival compared with surgery and adjuvant therapy (hazard ratio [HR] =1.66, 95% confidence interval [CI] = 1.01, 2.73,
Patients with local and regional disease treated with surgery alone have the best survival, perhaps because of localized disease originating in the external auditory canal with minimal extension into the middle ear. Although the cases may be originating within the temporal bone, the true site of origin for middle ear cancers is ambiguous and a stricter coding system is needed.
Although chemotherapy is a common treatment for pulmonary metastasis of head and neck cancer, the prognosis is still poor. This study aimed to examine and evaluate the efficacy of surgical resection for pulmonary metastasis of head and neck cancer.
A total of 15 patients who had undergone 19 resections were examined at our hospital between 2005 and 2012. The patients were followed up for at least 22 months after the surgery, or until their death, with a median period of 36 months. Among the 15 patients, 11 had squamous cell carcinoma, 3 had adenoid cystic carcinoma, and one had malignant melanoma.
Of the 19 resections, partial lung resection was performed in 13 cases, lobectomy in 4, and segmentectomy in 2. Video-assisted thoracic surgery was performed in all cases. The mean surgical time, operative blood loss, and length of postoperative hospital stay were 104 minutes, 64 mL, and 7.8 days, respectively. Only 1 patient showed deterioration of the postoperative performance status. For patients with squamous cell carcinoma, the number of pulmonary metastases was 2 or less at the preoperative evaluation. The 3- and 5-year disease-specific survival rates after surgical resection in patients with squamous cell carcinoma were 54.6% and 20.5%, respectively. All patients with adenoid cystic carcinoma and malignant melanoma have survived to date.
Lung surgical resection can be considered as one of the effective treatments for pulmonary metastasis of head and neck cancer to improve patient prognosis, with minimal invasion and complications.
Evaluation of the clinical and pathological factors associated with treatment and outcomes for external auditory canal (EAC) carcinomas.
Over the 20-year period from 1993 to 2013, a retrospective review of clinical and pathological analysis was performed on 23 patients who were histologically diagnosed with EAC carcinomas and treated at Hamamatsu University Hospital. We evaluated the clinical staging, treatment methods, pathological diagnosis (particularly squamous cell carcinoma [SCC])), and patient outcomes. Main outcome measures included staging, treatment procedures, pathological features, and estimated survival rates.
The 5-year overall survival (OS) of the subjects was 75.2%, and the 10-year OS was 60.2% with the Kaplan-Meier method. The prognosis for SCC was poor when compared with other carcinomas (
Our survival analysis data for carcinoma of the EAC demonstrates that SCC and unresectable cases are associated with poor outcomes, and outcomes for subjects with operability more closely parallel the survival curves of advanced stage T4 disease. Patients with SCC should be strictly categorized as cases with severe disease.
(1) Evaluate and compare the effectiveness of tongue depressors and the Dynasplint Trismus System to manage trismus in head and neck cancer patients. (2) Analyze factors that may indicate improved outcomes for patients in trismus management.
Single-institution randomized controlled cross-over study (2007-2013). Fifty-three patients with trismus as a complication of cancer treatment were enrolled in the study at an academic tertiary care center. Twenty-seven patients were randomized to a treatment arm using Dynasplint, while 26 were enrolled in a treatment arm using tongue depressors to perform stretching exercises. The primary outcome was interval measurement of incisor-to-incisor opening during and at the completion of tongue depressor therapy compared to Dynasplint usage. Pretreatment and treatment characteristics, including type of cancer treatments used, were analyzed for association with rate of improvement.
Dynasplint and tongue depressors both significantly increased the maximal incisal opening of patients at 3 months compared with baseline (
Surgical therapy alone responds better to trismus therapy compared to dual modality therapy. Both Dynasplint Trismus System and tongue depressors were able to improve the trismus status for patients with equal effectiveness. Ease of use and cost favor the management with tongue depressors.
In advances in robotic thyroidectomy, we have performed robotic lateral neck dissection by a gasless unilateral axillo-breast (GUAB) or axillary (GUA) approach for differentiated thyroid carcinoma (DTC) to avoid long visible scars in the neck. The aim of this study is to evaluate technical feasibility and efficacy of robotic lateral neck dissection compared with conventional neck dissection.
We studied 72 patients with DTC who underwent total thyroidectomy with robotic selective neck dissection by GUAB or GUA approach (23 cases) or conventional open neck dissection (49 cases) in the unilateral neck between January 2010 and July 2013.
The mean age and body mass index was lower, and female sex was more common in the robotic group compared with the open group (
Robotic lateral selective neck dissection by GUAB or GUA approach is comparable to conventional lateral neck dissection in selected patients with DTC and provides better postoperative cosmesis than conventional neck dissection.
The incidence of depressive symptoms in head and neck cancer (HNC) patients has been shown to be up to 40% during treatment and can affect patients’ desires to rehabilitate after surgery. The objectives in this study were to (1) evaluate the relationship between preoperative depressive symptoms and postoperative functional performance status (PFPS) and (2) assess the effect of preoperative depressive symptoms on length of hospital stay (LOHS), completion of adjuvant therapy (CAT), rate of postoperative readmission, and loss of follow-up.
A prospective cohort study was conducted in new adult HNC patients undergoing surgery as primary therapy from January 2013 to January 2014 measuring baseline preoperative depressive symptomatology on the Quick Inventory of Depressive Symptomatology (QIDS) and PFPS was assessed on the Functional Assessment of Cancer Therapy-Head & Neck (FACT-HN) 6 months from the initial presentation. Secondary outcomes assessed included LOHS, CAT, rate of readmission due to failure to thrive, and loss of follow-up. A Mann-Whitney
Preliminary results of the prospective study demonstrate an incidence of preoperative moderate-severe depression of 29.2% and significant difference in FACT-HN scores between moderate-severely depressed patients and those with normal-mild symptoms (
Depression should be recognized as a contributive factor in postoperative functional performance status.
Evaluate the advantages and disadvantages of Evicel fibrin sealant when used in thyroid surgery closure, taking into account the following endpoints: postoperative drain output, time to drain removal, length of admission, and adverse events.
From June 2010 to January 2014, an institutional review board–approved prospective, randomized, double-blind study of Evicel versus a saline control was conducted on 70 subjects receiving total thyroidectomy or hemithyroidectomy. Twenty-eight received Evicel and 27 received saline; data from 15 subjects were eliminated due to protocol violations. The mean age was 50.3 (range, 21 to 73).
Comparisons of baseline characteristics, including age, sex, and type of surgery, revealed successful subject randomization. There was no significant difference in drain output between Evicel (median [interquartile range]: 96.3 mL [73.3-139.3 mL]) and placebo (120.0 mL [68.8-161.5 mL],
Evicel sealant appears to be a safe, effective method to reduce serous drain output following total thyroidectomy but has a limited role in hemithyroidectomy due to low levels of baseline drain output.
Head and neck squamous cell carcinoma (HNSCC) has an unfortunately high rate of recurrence. Recent evidence suggests that the type of anesthesia used during surgery may affect a tumor’s molecular biology, thereby influencing its response to treatment. In this pilot study, we test the hypothesis that different forms of anesthesia will affect the differential expression of several pro-survival cellular proteins in HNSCC utilizing morphoproteomic analysis.
Between September 2013 and January 2014, 10 patients underwent surgical resection of previously untreated oral cavity and/or oropharyngeal SCCA. Preoperatively they were randomized to receive either sevoflurane (n = 5) or total intravenous anesthesia (n = 5). Immunohistochemistry of pre- and postprocedural tumor tissue was performed using the following markers: HIF-1A, HIF-2A, SIRT-1, mTOR, FASn, COX-2, c-MET, pAKT, NFkB, and pp38. Morphoproteomic scoring by a blinded pathologist was then employed to evaluate for differences in expression between the 2 groups.
Differential expression of several proteins was observed between the 2 groups. Specifically, sevoflurane was associated with increased protein expression in postprocedural tissue. Moreover, correlative analysis demonstrated an association between increased expression of several markers and specific tumor features (eg, perineural invasion).
While only preliminary, our results suggest that the form of anesthesia used during surgery may affect the molecular biology of HNSCC. This study represents one of the first to evaluate the effects of anesthesia on the molecular biology of HNSCC in vivo. However, larger, prospective studies are needed to better evaluate the effect of anesthesia on the postoperative outcomes of HNSCC.
Optimize and individualize post-thyroidectomy hypocalcemia management.
A multicenter, standardized prospective study was conducted. Demographic, clinical, and biochemical data were collected. Parathyroid hormone (PTH) was measured preoperatively, then at 1 and 6 hours postoperatively. The optimal required doses of calcium and vitamin D were defined as those maintaining the patients as asymptomatic and their cCa ≥ 2 mmol/L. They were used as an endpoint in a generalized linear mixed effect modeling (GLIMMIX) aiming to identify the best predictors of optimal required doses. Models were evaluated by goodness of fit (Akaike information criteria), receiver operating characteristic curves, and sensitivity analysis.
A total of 168 patients met inclusion criteria; mean age was 41.8 years, 85.1% were female, 49.3% had a body mass index (BMI) >30, and 64% had vitamin D deficiency. Of the patients, 25.6% had post-thyroidectomy hypocalcemia, of whom 18 (41.9%) were symptomatic and received intravenous calcium. First-hour percentage drop in PTH correlated positively with the severity of hypocalcemia (
Our findings could help in optimizing the management of post-thyroidectomy hypocalcemia. They can assist in early identification of those who are not at risk of hypocalaemia and can guide early effective management of those at risk.
Unlike head and neck squamous cell carcinoma (HNSCC) caused by tobacco and alcohol use, human papillomavirus (HPV)–related HNSCC has better survival outcomes. The aim of our study was to determine if post-treatment weight change was different between HPV positive and negative oral tongue and oropharyngeal squamous cell carcinoma (OPC) patients.
We conducted a retrospective cohort study. Oral tongue and OPC patients with initial surgery or radiation/chemotherapy in 2010 were identified using the University of Pennsylvania Tumor Registry. Those with p16 testing as a surrogate marker for high-risk HPV were enrolled. Patient characteristics at diagnosis were collected, and the outcomes were mean weights at pretreatment and 0-6, 6-12, 12-18, and 18-24 month posttreatment visits.
We identified 50 survivors with p16 testing and follow-up weights. Seventy-four percent (n = 37) were p16-positive. Compared with p16-negative patients, p16-positive patients were significantly more likely to be younger (56 ± 11 vs 72 ± 12,
Although the traditional post-treatment weight loss was still seen in p16-negative patients, p16-positive patients were able to gain weight during 24-month post-treatment follow-up after the initial rapid posttreatment weight loss.
(1) Investigate that early growth response-1 (EGR-1) expression is expressed in human head and neck squamous cancer (human HNSCC). (2) Evaluate whether EGR-1 affects radiation-induced apoptosis in human HNSCC and would thus serve as the proper prognostic biomolecular marker of radiation therapy.
The protein expression of EGR-1 by immunohistochemistry was investigated in human HNSCC tissues. EGR-1 expression was evaluated at different time points after irradiation in human HNSCC cell lines. To evaluate the impact of EGR-1 knock-down on radiation-induced apoptosis of human HNSCC cell lines, cell apoptosis assays using small-interfering RNA were performed. Western blot analysis was used to assess alteration in apoptosis related protein expression after irradiation in human HNSCC cell lines.
EGR-1–positive immunoreactions were observed relative to adjacent mucosal tissue in 15 tissues (58.6%) of 28 human HNSCC tissues. After 5Gy and 8Gy irradiation, EGR-1 increased with peak activation at 2 hours. The cleaved caspase 3, cleaved caspase 7, and cleaved PARP were increased at 2 hours after irradiation. Proapoptotic protein Bax was increased at 2 hours after irradiation. EGR-1 knock-down cells displayed decreased radiation-induced apoptosis, compared with control cells in cell apoptosis assay. Cleaved caspase 3, cleaved caspase 7, cleaved PARP, and Bax activation was decreased by EGR-1 knock-down after irradiation.
EGR-1 had abundant expression in human HNSCC tissue. EGR-1 knock-down decreased radiation-induced apoptosis through caspase 3, caspase, 7, PARP, and Bax. EGR-1 may play an important role in treatment response after radiation therapy in human HNSCC.
The plasma volume expander hetastarch has a suggested subclinical toxicity that increases activated partial thromboplastin time and decreases Factor VIII of the coagulation cascade. The goal of this study was to determine if free tissue transfer patients who received hetastarch intraoperatively had a decreased risk of developing microvascular anastomotic venous thrombosis.
The records of all patients undergoing free tissue transfer between January 1, 2009, and May 1, 2013, were selected for retrospective chart review. Background data including patient demographics, surgical indications, and free flap types were collected. Intraoperative medication records were analyzed to determine hetastarch administration. The primary outcome evaluated was anastomotic venous thrombosis. Secondary outcomes assessed included anastomotic arterial thrombosis, hematoma formation, and flap failure.
During the collection period, a total of 106 patients received hetastarch intraoperatively as a plasma volume expander, compared with 43 who did not. No statistical difference was demonstrated between groups with regard to demographic information, surgical indications, and free flap types. There was no significant difference between groups in the rate of venous thrombosis (
This study demonstrates that the intraoperative administration of hetastarch during free tissue transfer procedures does not significantly decrease the rate of postoperative venous thrombosis, arterial thrombosis, or free flap failure and, despite its anticoagulatory effects, does not significantly increase the rate of hematoma formation. Therefore, we conclude that utilization of intraoperative hetastarch does not significantly impact the complication rate of microvascular anastomoses.
Report the results of a consecutive series of patients who underwent an endoscopic endonasal transphenoidal approach (EETA) for resection of a pituitary adenoma.
A retrospective review of patients who underwent EETA at our center between 2010 and 2013, in a collaboration between head and neck surgeons and neurosurgeons, and a description of the technique used.
Nineteen patients underwent an EETA for removal of a pituitary adenoma. Decreased visual acuity or a visual field defect was the presenting complaint in 63.2% patients and headache in 26.3%. Nonfunctioning adenoma was the most frequent (52.6%). Sixteen (84.2%) patients had a macroadenoma (>1 cm) and 3 (15.8%) had a microadenoma (<1 cm). The overall postoperative cerebrospinal fluid leak rate was 5.3%. Other perioperative complications were epistaxis (5.3%), postsurgical hematoma (5.3%) with urgent evacuation, and meningitis (5.3%). The rate of gross total ressection was 70% in patients with nonfunctioning adenomas. The remission rate of secretory adenomas was 75%. Of the patients presenting with visual symptoms, 91.7% improved or normalized.
EETA is an excellent alternative to other classic approaches for pituitary adenoma, providing similar results with less morbidity. It allows a better panoramic visualization of sellar and parasellar spaces and a better preservation of the normal anatomy and physiology of nasal cavity. This minimally invasive approach is now the standard of care in transasal pituitary surgery. Our outcomes, including remission and complication rates, are comparable with those reported in previous series of endoscopic and microscopic approaches.
Livin, a member of the inhibitors of apoptosis protein family, is expressed in various cancers and is associated with tumor progression. However, there is no report about the significance of Livin in laryngohypopharyngeal sqaumous cell carcinoma (LHSCC). In this study, we evaluated the expression of Livin in human LHSCC and investigated whether Livin knockdown using small interfering-RNA (siRNA) affects tumor aggressiveness in LHSCC cells.
Livin expression in human LHSCC tissues was detected by immunohistochemistry. The relationships between Livin expression and clinicopathologic variables were analyzed. Livin specific siRNA was used to silence the endogenous Livin gene expression in SNU1041 and PCI1 human LHSCC cell lines. Cell invasion, cell migration, and cell apoptosis assays were performed to assess the impact of Livin on cancer cell behavior in human LHSCC cells.
High immunoreactivity of Livin was observed in 22 (36.7%) of the 60 LHSCC tissues relative to adjacent normal mucosa. In the positive Livin expression group, distant metastasis tended to occur frequently, but the difference was not statistically significant (
These results suggest that Livin silencing mediated siRNA may be associated with the reversal of invasive capacity in LHSCC.
Evaluate how much the endotracheal tube moves on neck extension in patients undergoing elective thyroid surgery and whether this is affected by body mass index (BMI) or neck length.
Prospective study of 20 patients undergoing thyroidectomy during a 4-month period in 2013-2014. Patient demographics, BMI, collar size, sterno-mental distance, and sterno-cricoid distance were recorded. The electromyography endotracheal tubes used in thyroid surgery were marked at 1 cm, and the distance was noted in the neutral and extended (30° as tolerated) neck positions.
The mean age of patients was 46.4 years (range 26-68 years). There were 18 female and 2 male patients. The mean BMI was 28.2 (range, 20.1-32.6) and mean sterno-mental distance was 15.2 cm (range, 9.8-20.4 cm). The mean upward displacement of the endotracheal tube during neck extension was 22.2 ± 7.6 mm. Patients with a larger BMI (>25) had a significantly smaller amount of tube displacement than patients with a smaller BMI (<25; 17.1 ± 7.3 mm vs 24.5 ± 8.1 mm,
Neck extension results in upward displacement of the endotracheal tube. The amount of displacement is significantly lower in patients with a larger BMI or shorter neck length, possibly due to the limitation of neck extension in these patients. This has particular relevance for thyroidectomy patients in whom accurate positioning of the tube is essential for nerve monitoring.
Evaluate whether patient demographics and hospital characteristics are associated with a patient’s likelihood of undergoing transoral robotic surgery (TORS) for head and neck cancer.
A cross-sectional analysis of 13,193 patients who were admitted to US hospitals in 2009 and 2011 with a primary diagnosis of head and neck cancer was performed using data from the Nationwide Inpatient Sample. A multinomial logistic regression model was used to calculate the likelihood of undergoing TORS based on age, sex, race, household income quartile, insurance status, hospital size, hospital region, and hospital teaching status.
A total of 181 patients underwent TORS for head and neck cancer in the years 2009 and 2011. With regard to demographic factors, Hispanic patients and those within the lowest 2 income quartiles were significantly less likely to undergo TORS when compared with white patients and those within the highest income quartile (odds ratio [ORs] 0.27 confidence interval [CI; 0.09-0.80], 0.48 CI [0.29-0.80], 0.54 CI [0.34-0.87]). With regard to hospital characteristics, patients treated at hospitals in the northeast and south and those treated at nonteaching hospitals were significantly less likely to undergo TORS than those treated at hospitals in the west and those treated at teaching hospitals (ORs 0.48 CI [0.31-0.73], 0.43 CI [0.28-0.64], 0.27 [0.16-0.44]). There were no significant differences found between patients of different age groups or patients treated at different sized hospitals.
Racial, socioeconomic, and regional disparities exist in the availability of TORS to head and neck cancer patients.
Determine if the extent of parotidectomy or other patient or tumor characteristics influence the rate of sialocele or salivary fistula formation after parotidectomy.
A retrospective chart review was performed for all patients who underwent parotidectomy at the University of Wisconsin from 1994 to 2013. Patients who developed a sialocele or salivary fistula at any time postoperatively were identified. Age, sex, area and size of defect, body mass index (BMI), and rate of malignancy were evaluated to assess any relationship to these complications.
A total of 771 patients underwent parotidectomy at our institution from 1994 to 2013. Of these, 75 (9.7%) developed a sialocele or salivary fistula. Sialoceles or salivary fistulas developed in 96% (72/75) within 1 month post-parotidectomy, and none developed after 6 months. Age, sex, BMI, and histology were not associated with sialocele or salivary fistula formation. Extent of parotidectomy was quantified through assessment of surgical volume of tissue removed. The average volume of tissue removed was 37.8 cubic centimeters (cc) (range 0.2-277 cc; 95% confidence interval [28.4 cc, 47.2 cc]). Sixty-four patients (85.3%) underwent superficial parotidectomy, 7 (9.3%) underwent total parotidectomy, and extent of surgery was not documented in 4 patients (5.3%). 2 patients (2.7%) underwent revision surgery. Of patients who underwent superficial parotidectomy, 28 (43.8%) were complete superficial parotidectomy and 23 (35.9%) were partial inferior superficial parotidectomy.
Sialocele is an uncommon complication post-parotidectomy. Contrary to other studies, we observed that sialocele formation does not depend on amount of parotid tissue removed, site of parotidectomy, gender, age, BMI, or rate of malignancy.
(1) Describe temporal trends in the use of postoperative intensity-modulated radiotherapy (IMRT) for head and neck cancer treatment. (2) Determine factors associated with the utilization of IMRT.
A retrospective analysis of the National Cancer Database (2003-2011) was used to identify 45,154 adult head and neck cancer patients who had postoperative radiotherapy (RT) and to examine demographic, geographic, socioeconomic, and clinical characteristics. Our main outcome of interest was the receipt of IMRT. Statistical analysis included χ2 tests, Student
From 2003 to 2011, the proportion of patients who had postoperative IMRT increased from 14.2% to 69.2%. Compared with those who had non-IMRT, patients who had IMRT were more likely to be <55 years old (58.4% vs 66.7%,
IMRT has become the primary modality of delivery for postoperative RT in head and neck cancer patients. Results demonstrate racial, regional, and hospital-level variation in the receipt of IMRT, suggesting heterogeneity in practice patterns across the United States.
Modifications to the Guidelines for the Management of Asymptomatic Primary Hyperparathyroidism (2008) eliminated the recommendation for routine 24-hour urine calcium collection. Surgeons are now seeing an increasing number of referrals for surgical evaluation of hyperparathyroidism without this test that can help differentiate between primary hyperparathyroidism (PHPT), a surgical disease and familial hypocalciuric hypercalcemia (FHH), a medical disease. We will review the characteristics of our cohort of FHH patients and describe findings that should raise suspicion for this diagnosis.
Subjects were evaluated at Oregon Health and Science University from 2011 to 2013. Retrospective chart review was performed of a cohort of 11 patients with FHH confirmed by calcium-creatinine clearance ratio (CCCR) and/or CASR gene mutation.
All patients had CCCR of <0.015, In 8 patients imaging studies could not localize an adenoma, and 6 patients reported a family history of hypercalcemia.
FHH is a benign, autosomal dominantly inherited disorder from heterozygous mutations in the calcium sensing receptor gene, resulting in lifelong hypercalcemia and relative hypocalciuria. Suspicion for FHH is raised with the presence of long-term hypercalcemia, a positive family history of hypercalcemia, and inability to localize an adenoma on imaging studies. Further evaluation is indicated including a 24-hour urine calculation of the calcium creatinine clearance ratio (CCCR). Significant clinical overlap with PHPT presents certain diagnostic challenges. Additionally, we report novel CASR mutations clinically associated with FHH, highlighting the broad spectrum of this disorder. Heightened awareness of the diagnostic criteria for FHH should decrease the incidence of unnecessary surgeries performed.
Nerve degeneration after transection decreases intraoperative visibility under white light (WL), complicating repair and increasing the risk of additional injury to surrounding tissue. We previously described F-NP41, a fluorescently-labeled peptide which highlights peripheral nerves following systemic injection. In this study, we analyzed whether F-NP41 highlights degenerated nerves and evaluated the use of additional fluorescence guidance in delayed facial nerve repair procedures.
Degenerated distal facial nerve branches were imaged under WL and with fluorescence after systemic F-NP41 application 1, 2, 3, 6, and 9 months (n = 4 per time point) after main branch transection. Nerve to non-nerve tissue contrast was compared. Facial nerve repair surgeries with a cable graft were performed 6 weeks after transection, using WL alone (n = 9) or additional fluorescence guidance (n = 10). Time to nerve identification and total operating time were measured; postoperative functional recovery was assessed weekly by quantitative measurement of whisker movement for 6 weeks.
Nerve to non-nerve tissue contrast was increased >2-fold using fluorescence imaging versus WL at all time points (
F-NP41 significantly improves intraoperative visualization of degenerated nerves in mice up to nine months following injury compared with WL alone. The use of F-NP41 decreases intraoperative time to nerve identification by nearly 40%, thus reducing operating time and potentially improving functional recovery.
(1) Name the 4 most common locations of head and neck paragangliomas (HNPGs). (2) Describe 2 pathological and 2 radiological tools used in the diagnosis of HNPGs (with their respective diagnostic accuracy rates).
The purpose of this study was to record the diagnostic accuracy of fine needle aspiration cytology (FNAC) in the diagnosis of different types of HNPG. We retrospectively collected data on all HNPGs diagnosed in our institution between January 1986 and April 2013. We recorded patient demographic factors along with diagnostic and clinical details.
Altogether 35 HNPGs were seen and treated in our institution in the studied period. In 15 (43%) cases FNAC was used as the first line diagnostic tool with or without ultrasound (USS) guidance. Radiological imaging (USS/computed tomography/magnetic resonance imaging) always accompanied FNAC. In the remaining 57%, clinical assessment alone or in combination with core biopsy accompanied radiological imaging. Eight (53%) out of 15 HNPGs were diagnosed correctly with FNAC; all those were carotid body tumors (CBTs). Of the rest, 1 false diagnosis of microfollicular oncolytic thyroid lesion was histologically a combined thyroid paraganglioma (PG) and Hurtle cell adenoma. One patient was treated conservatively and 4 inconclusive samples were histologically a laryngocele, a CBT, a jugular PG, and a combined CBT + contralateral PG with intracranial extension. For 1 patient full FNAC details were not available.
FNAC can diagnose CBTs with good diagnostic accuracy. HNPGs arising in other regions of the head and neck can be challenging to diagnose without histopathologic and immunohistochemical tools.
(1) Defining functional swallowing outcomes as well as determining an expected length of time for patients to safely return to a normal oral diet in transoral robotic surgery (TORS) for resection of supraglottic laryngeal cancer.
Retrospective chart review of patients who underwent TORS for resection of laryngeal cancer from 2011-2013. ASHA’s National Outcomes Measurement System, oral diet levels, and dependency on tube feedings were used as outcome measures.
Eleven patients were included in this study. Five out of 11 patients completed the treatment program and follow-up care, 100% returned to full oral diets in an average of 18.6 weeks, and all subsequently had their g-tube removed. Sixty percent of these patients continued to require compensatory swallowing techniques (ie, supraglottic swallowing maneuver) and/or modified diets (ie, thickened liquids) in order to safely consume oral diet without aspiration. Two patients died; 1 patient was lost to follow-up; 3 patients were still NPO at last contact.
Patients who have undergone supraglottic laryngectomy will likely experience significant dysphagia, but good functional swallowing outcomes should be expected in the intermediate term.
(1) Understand the types of complications affecting head and neck free flap reconstructions. (2) Compare the incidence of flap complications between patients with and without prior irradiation.
Systematic review and meta-analysis of all studies of head and neck free flap reconstructions between January 1993 and October 2013. Studies that included separate data for patients with and without prior irradiation were analyzed for differences in demographics, flap type, and complications using Poisson regression and odds ratios.
Fourteen studies encompassing 701 free flaps in irradiated patients and 328 free flaps in nonirradiated patients were included. The 2 groups were comparable in age (
Head and neck free flap reconstruction in irradiated patients carries an increased risk of complications. The largest effect sizes were seen in risk of fistula, vascular thrombosis, hematoma, and partial flap loss, although these did not individually reach statistical significance. However, overall flap survival was similar in patients with and without radiation.
Assess the safety, patient satisfaction, and outcome of day case hemithyroidectomy in our department.
A prospective audit of all patients undergoing hemithyroidectomy in a single institution over a 3-year period. All patients who undergo a hemithryoidectomy in our department have a bilateral superficial cervical block using 20 mL of 0.25% chirocaine, 10 mL of xylocaine with 1% adrenaline, and minimal opioid use. Bipolar dissection is used with meticulous hemostasis to avoid the use of a drain. All patients are reviewed 1 week postoperatively, and patient satisfaction questionnaires are completed.
One hundred fifty patients had a hemithyroidectomy over the 4-year period. Average age was 49 years (21-77). Male to female ratio was 3.9:1. Average length of stay was 0.47 days (0-6). Eighty-one percent of patients had their operation performed as a day case. The main reasons for patients not having surgery performed as a day case were patient choice, social reasons, and medical complications postoperatively. There were no hematomas requiring a return to theater and no drains inserted. No patient required readmission after discharge. Average patient satisfaction score for those discharged as a day case was 9.09 (0: not satisfied to be discharged as a day case - 10: very satisfied to be discharged as a day case). Average pain score day 1 postop was 3 (0: no pain at all - 10: worst pain imaginable).
Day case hemithyroidectomy is very agreeable to patients and if appropriate analgesia is used then the postoperative pain is minimal.
(1) Examine the added value of galectin-3 to HBME-1 staining on fine-needle aspiration (FNA) of thyroid nodules. (2) Correlate galectin-3 on FNA with pathology results both on FNA and final surgical pathology.
A retrospective review of the charts of 53 patients undergoing FNA at the Jewish General Hospital in Montreal, Canada, in 2013 for the investigation of thyroid nodules whose FNA samples underwent HBME-1 and galectin-3 staining in addition to pathological examination.
Of 53 FNABs, 20 (37%) were galectin-3 positive, 24 (45%) were galectin-3 negative, and 9 (17%) were equivocal. With regard to HBME-1, 15 (28%) samples were positive, 32 (60%) were negative, and 6 (11%) were equivocal. Both stains correlated strongly with each other (
Galectin-3 may be a useful adjunct to HBME-1 staining in FNA of thyroid nodules in order to detect papillary thyroid carcinoma. Further research is needed to confirm these results.
Head and neck squamous cell carcinoma (HNSCC) is known as one of the 6 most common human cancers mainly caused by consumption of tobacco and alcohol. There is also a genetic factor; however, the genetic markers are not yet established. Our objectives were to (1) validate the genetic signature of molecular targets expressed by tumors in HNSCC and (2) determine potential biomarkers for earlier detection, potential therapies, and prediction of patients’ survival.
The HNSCC patients were recruited to the study in the Greater Poland Cancer Centre in 2010. Oral cancer and normal epithelium tissue taken at a minimum of 2 cm distal from the tumors’ margins from 41 patients were used for analysis by Cancer Pathway Finder array and followed with real-time polymerase chain reaction.
Analysis indicated up-regulation of 11 genes including KRT14, ACLY, MCM2, SKP2, STMN1, CDC20, SNAI2, MKI67, SLC2A1, BCL2L11, and IGFBP3 (
Our data indicate that there is significant activation of several cellular pathways in tumor tissue that should be further investigated. Importantly, observed significant association between the expression of skp2, cdh2, vegfc, and bcl2l11 and survival indicate that the larger the difference between the expression in tumor and normal tissue of these genes, the shorter the survival time of the patient.
(1) Evaluate quality of life (QOL) outcomes in head and neck cancer survivors at our institution. (2) Recognize areas of improvement in our head and neck cancer survivors in order to decrease morbidity and mortality.
A total of 53 patients completed a 24-question QOL survey, previously validated by Terrell et al. The study was conducted between 2013 and the present day.
Sixty-two percent were male, and the average age was 64. Patients were on average 1.8 years past their definitive surgery. Thirty-eight percent were current tobacco users and 30% were former tobacco users. Most cases were squamous cell carcinoma (92%) of the oral cavity/oropharynx and hypopharynx/larynx (57% and 30%, respectively). All stages were represented (I: 19%, II: 28%, III: 13%, IV: 34%). Fifty-four percent underwent radiation therapy, and 26% underwent chemotherapy. Overall, patients were satisfied with speech, eating, pain, emotional toll, and overall disturbance (71% ± 27 [SD], 76% ± 19, 80% ± 23, 76% ± 22, and 70% ± 23 respectively). Overall, patients were very satisfied with their head and neck care at our institution (93% ± 12%). Most patients quit using tobacco products after their cancer treatments/diagnosis.
Overall, most patients were satisfied with pain, speech, eating, emotional impact, and overall disturbance. However, the standard deviation was large. This finding could be related to pooling of all the results. Future studies are planned to evaluate quality of life outcomes based on stage, location, and/or time since surgery.
(1) Analyze the treatment approach for these rare salivary gland neoplasms at our institution. (2) Demonstrate observed patterns of failure and survival for high-grade salivary duct carcinoma (HGSDC) involving the parotid glands.
Clinical data on 17 patients with nonmetastatic HGSDC involving parotid salivary glands from 1998 to 2012 were abstracted from our institutional database. Inclusion required surgical resection with postoperative radiotherapy (n = 8) or concurrent chemoradiotherapy (n = 9). Demographics, histopathologic features, treatment course, and clinical outcomes were recorded. Specimens were re-reviewed by a dedicated head and neck pathologist. Overall survival (OS) and disease-free survival (DFS) were estimated via Kaplan-Meier method, and comparisons were made with the log-rank test.
Median patient age was 65 years (range, 52-83 years) with a male:female ratio of 7.5:1 and median follow-up of 37 months. Most commonly, these cases presented as pT4a (n = 14) with adverse clinical features, including perineural invasion (76.5%), positive lymph nodes (76.5%), and vascular invasion (58.8%). Three-year DFS and OS were 35.7% and 61.4%, respectively. The pattern of treatment failure was predominately distant (n = 11) versus locoregional (n = 3). Univariate analysis of demographic, histopathologic, and treatment characteristics did not reveal a significant association with OS or DFS. Median survival after metastasis was 13 months, with only a single patient having a sustained treatment response >2 years after disease dissemination.
In this series, we highlight the aggressive nature of high-grade salivary duct carcinoma, which has a significant risk of distant recurrence and poor overall survival.
We designed this study to develop an efficient and cost-effective screening tool for detecting voice disorders following thyroidectomy.
We developed the Perioperative Voice-Screening Protocol for Thyroid Surgery (PVST) using the Thyroidectomy-Related Voice Questionnaire (TVQ) to provide a cost-effective diagnostic flow sheet for patients following thyroidectomy. The TVQ is a simple questionnaire that was developed at our institution and has already demonstrated its effectiveness in detecting pre- and post-thyroidectomy voice-related disorders in our previous studies. To investigate the PVST, we enrolled 242 subjects who underwent thyroidectomy and let them follow the PVST. All subjects underwent a voice work-up by a voice specialist to verify the predictive value of the protocol.
Using PVST, we could effectively screen for abnormal preoperative laryngeal findings with a sensitivity and specificity of 82.1% and 50.5%, respectively, especially laryngeal benign mucosal disease with a sensitivity and specificity of 100% and 45.6%, respectively. We could also screen for postoperative voice-related problems with a sensitivity and specificity of 100% and 50.4% for detecting vocal cord palsy, and 66.7% and 51.2% for detecting a low-pitched voice, respectively. When all 242 patients followed the protocol, US $42,768 would be saved, and the PVST was estimated to decrease costs by 43.5%.
The PVST is a reliable and cost-effective perioperative screening tool that enables thyroid surgeons to detect patients with voice problems in their routine outpatient clinic for early and appropriate referral to voice specialists.
Effective head and neck cancer care requires a multidisciplinary approach. Proper coordination, or lack thereof, can greatly influence delays in treatment. Proper coordination can be improved with the help of patient navigation via cancer care coordination. Finally, there is scarce research on what is an acceptable delay in treatment of head and neck cancer and its impact on patient outcomes. The aim of this study is to determine how a cancer care coordinator (CCC) for patient navigation may improve timeliness of care and patient compliance.
A retrospective and prospective cohort of 161 veterans at the Washington, DC, VA who were diagnosed with head and neck cancer after January 1, 2007, were studied. The cohort was divided into 2 groups: patients diagnosed before versus after the advent of the CCC at our institution. These groups were compared for their average diagnosis-to-treatment time and for average time from diagnosis to completion of treatment.
The overall mean time from diagnosis to treatment initiation was 47 days. The CCC group had an average time of 41 days and the group without CCC had an average of 63 days. The overall mean time from diagnosis to completion of treatment was 127 days—92 days for the CCC group and 148 days for the group without CCC.
These results clearly show that CCC can both decrease time to initiation and completion of treatment. With further studies and survival data in our cohort, we can define a guideline for timeliness of treatment and describe the role of cancer care coordination in head and neck malignancy.
The prevalence and significance of high-risk oral human papillomavirus (HPV) among veterans treated for oropharyngeal squamous cell carcinoma (OPSCC) remains unknown. In this study, we aimed to (1) define the prevalence of HPV among veterans with OPSCC and (2) compare outcomes of veterans with OPSCC relative to high-risk HPV status and other well-known prognostic factors.
Patients from a high-volume Veterans Administra-tion (VA) medical center with OPSCC were identified from 2001-2006. Demographic, surgical, and pathological data were extracted from the electronic medical record. P16 immunohistochemistry testing was performed on archived pathological samples as a surrogate marker for HPV status. Outcomes were compared between HPV-positive (+) and negative (–) patients using Kaplan-Meier estimates.
Seventy-six veteran patients with available tumor tissue and follow-up data were included. All of the patients were male (100%) and the vast majority were ever smokers (89%). Most patients presented with advanced stage disease (61, 80%) and were treated nonsurgically (64, 84%). The overall prevalence of p16 positivity was 52 out of 76 (68%). Overall survival at 2 and 5 years was 60% and 38%, respectively, for the entire cohort. HPV+ veteran patients had significantly better survival at 2 years (58% vs 33%) and 5 years (40% vs 17%) than HPV– veteran patients (
Using p16 as a surrogate marker, HPV is prevalent among veteran patients treated for OPSCC. Veteran patients with HPV-associated OPSCC have improved survival relative to HPV-negative patients. However, their prognosis remains poor compared to a nonveteran population.
Human papillomaviruses (HPV) are a well-documented cause of a subset of head and neck cancer. Studies have shown the prevalence of HPV infection is around 7% in the general US population. Yet data from an Asian population and analysis from different head and neck subsites are sparse. In this retrospective case control study, we systematically reviewed data from subjects diagnosed with squamous cell carcinoma of the oral cavity, oropharynx, larynx, and hypopharynx in Chinese patients at Yan Chai Hospital.
Surgical specimens or biopsies were prospectively sent for detection of HPV DNA by polymerase chain reaction and immunohistochemical staining for p16 and p53.
In the 110 specimens obtained, preliminary results showed the overall prevalence of HPV was 21%. HPV 16 accounted for the majority of HPV-positive oropharyngeal squamous cell carcinoma (SCC; 85%) and laryngeal SCC (66%). Other oncogenic HPVs, apart from HPV16 and 18, were rarely detected in our series. In the multiple logistic regression analysis, HPV-associated oropharyngeal and oral cavity patients showed better overall survival, but this was statistically insignificant for laryngeal and hypopharyngeal patients. HPV positive and negative patients showed no statistically significant difference in disease staging on presentation as well as treatment modalities.
The prevalence of HPV associated head and neck cancer is much lower in Hong Kong Chinese. Our overall survival of HPV associated oropharyngeal and laryngeal cancer showed consistent favorable outcomes compared with those of other western countries.
Human papillomaviruses (HPV) seem to be related to distant metastasis (DM) in advanced oral cavity squamous cell carcinoma (OSCC) patients. The objective of this study was to investigate whether high-risk HPV viral load may predict DM among patients with OSCC and stratify patients for risk-adapted treatment.
We measured viral load of E7 oncogenes for HPV-16 and HPV-18 by quantitative PCR tests in paraffin-embedded surgical specimens from 312 OSCC of which the HPV genotypes had been determined previously. Multivariable regression analysis was used to identify the independent prognostic factors for 5-year DM.
Only the HPV-16 E7 viral load was a significant adverse predictor of 5-year DM. By multivariable analysis, high HPV-16 E7 viral load (≥15.0 copies/genome); pathological N2 status (pN2); tumor depth ≥11 mm; extracapsular spread (ECS); and level IV/V metastases were independent risk factors for DM and identified 3 prognostic groups. In the high-risk group (level IV/V metastases or high HPV-16 E7 viral load plus pN2, tumor depth ≥11 mm, or ECS), the 5-year DM rate was 77.5%. In the intermediate-risk group (high HPV-16 E7 viral load, pN2, tumor depth ≥11 mm, or ECS), the 5-year DM rate was 17.8%. Finally, the 5-year DM rate was 1.3% in the low-risk group (no risk factors).
Among OSCC patients, a high HPV-16 E7 viral load and the presence of specific pathological risk factor(s) identify a subgroup of patients at high-risk of 5-year DM. These subjects may benefit from a more intensive follow-up program and aggressive therapeutic strategies.
(1) Describe how thyroid molecular testing affects surgeon-performed ultrasound-guided fine-needle aspiration (FNA) with immediate on-site cytopathological interpretation. (2) Analyze percentage of inadequate FNA cytology (FNAC) and number of aspirations, comparing with and without surgeon-performed ultrasound guidance.
Retrospective cohort comparison. A cytopathologist is present for on-site staining (Diff-Quik) adequacy evaluation and molecular testing triage. This is followed by pap stain, cell block, and liquid-based cytology. Cytological adequacy and number of aspirations for 200 consecutive patients undergoing surgeon-performed ultrasound-guided FNA are compared with a series from the same surgeon without ultrasound guidance. A questionnaire subjectively scoring anticipated and actual pain from 1 through 10 (10 severe) was recorded immediately before and after FNAC.
Patients with an inadequate FNAC, with and without ultrasound guidance, were 0% and 3% (
Surgeon-performed ultrasound-guided FNAC with on-site cytopathology can largely eliminate inadequate FNA, potentially reducing the number of aspirations. Indeterminate FNAC can be triaged for molecular testing, performed in 9% of patients, potentially improving patient selection for surgery. The cytological interpretation can often be immediately communicated to the patient. Discomfort experienced is minimal.
Compare pathology margins of oral tongue cancer patients undergoing partial glossectomy between a novel surgical technique and conventional surgical resection. Describe the horizontal mattress surgical technique for partial glossectomy.
Patients with oral tongue cancer underwent partial glossectomy using a new surgical technique by the senior author from February 2011 to July 2013 at a tertiary care medical center. A retrospective comparison cohort was selected from prior patients of the department with age, sex, and tumor stage matching. Anterior, posterior, and medial pathology margins were compared between the groups. Mean values were compared with the Student
Ten patients underwent partial glossectomy with the new technique. The mean medial pathology margin was significantly greater in the novel technique group (1.40 cm, 0.88 cm,
The new surgical technique using horizontal mattress sutures for dissection guidance and specimen orientation yielded significantly larger medial pathology margins compared to the traditional method. This study is limited by the retrospective nature of the comparison group. A prospective trial should be undertaken to confirm these results.
Determine the human papillomavirus (HPV) infection and p53 protein expression in oral squamous cell carcinoma (OSCC) and their correlation with patient overall survival (OS) and disease-free survival (DFS).
HPV general and type specific 16 and 18 were investigated by means of PCR. P53 protein overexpression was investigated by means of immunohistochemistry. Results of HPV association and p53 overexpression were evaluated in relation to different clinicopathological parameters and survival.
Out of 140 patient samples HPV was detected in 95 (68%) cases, out of which 85 (90%) were associated with HPV16, 2 (2%) were associated with HPV 18, 2 (2%) were co-infected (with HPV 16 and 18), and 6 (6%) were positive for HPV by the general primer and could not be type specified. HPV positive patients had comparatively prolonged OS when compared with HPV-negative patients, but this difference was not statistically significant (
Our study found a high prevalence of HPV (type 16) in OSCC of Pakistani patients with male sex showing significant correlation with HPV. However, we did not find a statistically significant favorable association between p53 overexpression, HPV, survival, and histologic variables.
(1) Perform systematic review of the literature discussing methods of intraoperative detection of parathyroid glands. (2) Determine the feasibility of a low-cost visual identification method using cell phone camera and photographic color analysis.
A systematic review of the literature was undertaken to characterize experimental and existing techniques for real-time, intraoperative detection of parathyroid glands, a quest meant to reduce the incidence of post-thyroidectomy hypoparathyroidism. As an alternative to published techniques, photographs were taken during thyroid and other central neck surgery, using a variety of cell phone-based cameras, under variable lighting conditions. An app used for red-green-blue (RGB) color analysis was employed to stratify known parathyroid tissue and surrounding fat and thyroid gland by RGB content.
The majority of published techniques were dependent on specialized, high-tech, and high-cost imaging equipment such as optical coherence tomography, or patient exposure to chemicals such as methylene blue. RGB analysis of camera phone photographs revealed a consistent pattern of red saturation in parathyroid tissue, regardless of lighting conditions or camera type. Using the same app to subtract red from the photograph visually enhanced the difference between parathyroid and surrounding fat and thyroid and confirmed the RGB findings.
Photographic RGB analysis used by the amateur photographer at little cost shows promise as an intraoperative parathyroid detection method. Cell phone photography is universally available, and this technique can be employed in a low-resource setting to prevent inadvertent removal of parathyroid tissue.
Smoking is the major risk factor for lung and head and neck cancer. The purpose of this study is to determine the clinical impact of the incidental head and neck positron emission tomography (PET)/computed tomography (CT) findings in patients undergoing investigation for lung cancer.
The reports from PET/CT studies for patients with lung cancer from September 2005 and April 2012 were retrospectively reviewed. The incidental head and neck findings were interpreted as suggestive of second primary malignancy. These incidental findings were compared with the final diagnosis obtained from clinical and histological investigations.
A total of 592 patients were investigated for lung cancer in the study period. Head and neck PET/CT positive lesions suggestive of second primary malignancy were found in 65 (11%) patients. Twenty-three patients had nasoendoscopy, and a biopsy was done in 10 patients. In 4 (0.68%) patients, these lesions were proven of second primary malignancy: 2 squamous cell carcinoma (larynx and oral cavity), 1 undifferenciated carcinoma (parotid), 1 osteosarcoma (mandible). At a median follow-up of 13 months, 3 of 4 patients with a second primary died from a malignancy and 1 had no evidence of disease. Metastasis from lung adenocarcinoma was found in 2 (0.34%) patients.
PET/CT detected unexpected head and neck primary malignant tumors in at least 0.68% of patients with lung cancer. Among patients who underwent clinical investigations, 26.1% had a head and neck malignant tumor.
Hypocalcemia linked to a diminished circulating intact parathormone (iPTH) is the most common complication after total thyroidectomy. The outcome of our single-center prospective study is to determine the interest of iPTH as a predictor of post-thyroidectomy hypocalcemia.
One hundred eight patients who underwent total thyroidectomy were included. Blood samples (iPTH, calcium, and albumin) were performed at different times: preoperatively (H0), after removal of the gland (Hdrop), 6 hours (H6) after surgery, and one day (D1) after surgery. A measurement of calcium and albumin was performed on the second postoperative day (D2). The area under the receiver-operating characteristic (ROC) curve (AUC) was used to determine the best cutoff value and predictability of iPTH for hypocalcemia in terms of absolute value (ng/L), decrease in the slope (ng/L), and decline (%) between 2 times.
Seven patients were excluded. Of the remaining 101 patients, 39 had hypocalcemia (38.6%). At H6, an iPTH absolute value less than 14.35 ng/L (Se = 0.706; Sp = 0.917) and a decline from the preoperative time of more than 59.5% (Se = 0.850; Sp = 0.820) were predictive of hypocalcemia. Other absolute values, decrease in the slope, and decline between preoperative and postoperative values are less efficient.
The iPTH 6 hours after total thyroidectomy is predictive of hypocalcemia. It could be used to identify patients not at risk of hypocalcemia, and earlier discharge could be considered.
(1) Evaluate the frequency of invasion of the thyroid gland in patients with laryngeal or hypopharyngeal squamous cell carcinoma (SCC) submitted to total laryngectomy (TL) or pharyngolaryngectomy (TPL) associated with thyroidectomy. (2) Determine whether clinico-pathological characteristics can predict glandular involvement.
A retrospective study was conducted in an academically affiliated tertiary care referral center. Charts and anatomopathological reports of surgical specimens of 93 patients treated in the period from January 1998 to July 2013 were reviewed. All patients presented with laryngeal or hypopharyngeal SCC and underwent TL or TPL in association with thyroidectomy. Adjuvant therapy was indicated when tumor or neck conditions required it. Sociodemographic data, frequency of thyroid gland invasion, and other clinico-pathological variables were analyzed.
Tumor was staged as T2 in 10 patients, T3 in 26 patients, and T4 in 53 patients. Five patients had initial stage II and 88 had advanced stage III-IV disease. The overall frequency of invasion of the thyroid gland was 16.1%. Carcinomas that invaded the thyroid gland were more advanced (
Invasion of the thyroid gland is uncommon in the context of laryngopharyngeal SCC. Clinico-pathological features such as advanced tumors, T4a tumors, anterior commissure, subglottis, thyroid cartilage, and cricoid cartilage involvement are more associated with glandular invasion. Indications for thyroidectomy should be refined in order to reduce morbidity of the surgical treatment.
(1) Establish a best practices guideline for the surgical treatment of primary hyperparathyroidism within the context of single hospital system. (2) Stratify the group of patients who underwent directed excision by the accuracy of preoperative localization studies, and whether intraoperative techniques impacted cure, and at what resource costs.
In this retrospective chart review, patients were identified by searching all parathyroid-related procedures that took place at our institution from January 1, 2002, to December 31, 2013. Information related to the aims of the study, including demographics, operative details, and laboratory values were recorded, and imaging studies were reviewed by the senior investigator.
Of those patients with preoperative localization and directed excision, the preoperative studies most predictive of cure were a combination of Sestamibi parathyroid scan and surgeon-performed ultrasound. When these were in disagreement, surgical findings supported the ultrasound results. Intraoperative parathyroid hormone rapid assay was helpful in predicting cure, but added 68 minutes to the operating time on average. Most patients were surgically cured, and of the few patients with persistent high parathyroid hormone levels, vitamin D deficiency was the primary associated lab abnormality.
Analysis of techniques that predict a surgical cure allowed the development of a best practices algorithm that includes the following: (1) Obtain 2 preoperative localization studies, including a surgeon-performed ultrasound; (2) Obtain preoperative vitamin D levels and supplement as indicated; and (3) Reserve intraoperative parathyroid hormone assay only for those patients who do NOT have 2 corroborating localization studies.
We investigated extrathyroidal extension (ETE) through frozen biopsy for intraoperative decision-making in patients with papillary thyroid cancer (PTC).
During the period of the study an operation was performed in 268 patients with PTC and ETE was evaluated using intraoperative frozen biopsies of thyroid tissue.
ETE was confirmed in 54 patients (20%) on frozen biopsy. Fifty-three patients among 54 patients showing ETE on frozen biopsy were confirmed on permanent pathologic analysis. Accordingly, frozen biopsy had a sensitivity of 66%, a specificity of 99%, a positive predictive value of 98%, and a negative predictive value of 87%. Tumor size (odds ratio 4.373; confidence interval 2.257-8.475,
Intraoperative frozen biopsy can be a useful tool in identifying the presence of ETE. It can also help the operator decide the extent of surgery and central neck dissection in patients with PTC.
(1) Describe locoregional and distant disease recurrence patterns among patients undergoing maxillectomy from 2001-2011 at Cleveland Clinic and UCSF Medical Center. (2) Analyze the pattern of recurrence in this cohort in order to evaluate whether microvascular reconstruction may delay clinical detection of early cancer recurrence.
Retrospective review of patients undergoing inferior, subtotal, or total maxillectomy, with or without reconstruction, for control of malignant disease from 2001-2011 from 2 tertiary centers (Cleveland Clinic and University of California, San Francisco).
A total of 76 patients across the 2 institutions met the inclusion criteria for the study. Squamous cell carcinoma was the most prevelant pathologic diagnosis with overall disease progression of 29%. Recurrence at the skull base and regional lymphatic spread were the most common patterns identified (18 and 32%, respectively). Surveillance imaging, rather than direct observation on physical examination, raised suspicion for disease progression in the majority of cases. A total of 9 patients were found to have disease recurrence that could be surgically salvaged, with only 4 patients requiring modification to their reconstruction as part of the salvage operation.
Locoregional recurrence of malignancy after partial or total maxillectomy is uncommon, and the suspicion for disease recurrence is significantly more commonly raised on surveillance imaging, rather than on physical examination. Further, locoregional recurrence is rarely amenable to successful surgical salvage. This suggests that primary microvascular reconstruction of maxillectomy defects does not delay diagnosis or treatment of disease recurrence.
The feasibility and early surgical outcomes of robotic thyroidectomy have been reported. However, its oncologic outcomes are not well established. The aim of this study is to evaluate oncologic outcomes of robotic thyroidectomy compared with conventional thyroidectomy in differentiated thyroid carcinoma (DTC).
We analyzed 925 DTC patients who underwent robotic thyroidectomy (204 cases) using a gasless unilateral axillo-breast or axillary approach, or conventional open thyroidectomy (721 cases) with or without central neck dissection (CND) from October 2008 to December 2013. We excluded patients who underwent simultaneous lateral neck dissection or completion thyroidectomy and cases with recurrent cancer, other types of malignancy, or distant metastasis.
The male ratio and the mean age were significantly lower in the robotic group (
The oncologic outcome of robotic thyroidectomy in 5 years’ experience is comparable with conventional thyroidectomy in selected patients with DTC.
It has been postulated that treatment outcomes are similar between transoral robotic surgery (TORS) and definitive chemoradiation (CRT) for patients with oropharyngeal squamous cell carcinomas (OPSCC). We compared oncologic outcomes between OPSCC patients treated with definitive CRT and those treated with TORS only.
An observational comparison study was performed on 23 patients treated with TORS without adjuvant therapy and 33 patients treated with definitive CRT between July 2005 and December 2013. All patients had early stage disease with T0-T2 and N0-N2. Median age was 57 (range: 36-82) years and 80.4% of patients were male, which was similar between groups. Human papillomavirus (HPV)+ disease was present in 70.0% of TORS and 33.3% of CRT patients, although HPV status was not tested in 63.6% of the CRT patients.
Median follow-up was 22.5 months (range, 0.33-83.4 months). Local failure rate for the entire cohort was 7.1% (9.1% for definitive CRT, 4.3% for TORS,
Definitive CRT and TORS alone offer similar rates of locoregional control, distant control, and DFS in patients with early stage OPSCC. Further studies are needed to assess the effect of CRT and TORS on quality of life in this patient population.
(1) Recognize the frequency of level V neck node involvement in T3-T4 oral squamous cell carcinoma. (2) Analyze the need of level V neck dissection with N0 - N1 neck in T3-T4 oral squamous cell carcinoma (SCC).
Noninterventional, descriptive study from January 2011 to August 2012 at Dow University of Health Sciences & Civil Hospital Karachi, Pakistan, a tertiary care teaching hospital. Sampling was nonprobability and purposive. Histopathologically proven cases of squamous cell carcinoma of oral cavity with T3-T4 lesion and N0-N1 neck on basis of clinical examination and computed tomography scan findings were included in this study. All patients underwent modified radical neck dissection type-I along with excision of the primary growth.
Forty-nine patients fulfilling selection criteria were assessed on the basis of histopathological reports. At level I, metastatic lymph nodes were positive in 12 patients; 4 had positive nodes at level II and 2 each at level III and IV. However, none were positive at level V. Primary lesion was involving cheek in 40 and tongue in 9 cases. Histopathology revealed moderately differentiated SCC in 33 and well-differentiated SSC in 16 patients.
Our study suggests that level V neck dissection is not needed in oral SCC with N0-N1 neck even in T3-T4 lesions. However, as the sample size is small, further study with a larger number of cases is required to establish future guidelines for the extent of neck node clearance in oral cancer.
Depression in head and neck cancer (HNC) patients is undertreated and under-recognized, yet has been shown to be present in up to 40% of patients. The objective in this study was to perform a systematic review of the literature regarding the optimal psychologic intervention for HNC patients with depressive symptomatology.
A systematic review. PubMed, Medline, and ENCASE were searched in December 2013 for studies examining psychologic interventions in head and neck cancer patients. Results were screened by 2 independent reviewers. The level of evidence for each study and intervention were evaluated using criteria put forth by the Agency for Healthcare Research and Quality US Preventative Services Task Force. Subsequent analysis was then planned according to the criteria in the Cochrane Handbook for Systematic Reviews.
Eleven studies met inclusion criteria. Three studies were rated “good” for internal validity and 6 for external validity. Psychologic education and cognitive behavior therapy were evaluated by 8 studies, and antidepressant use was examined by 2 studies. Support group therapy was examined by 1 study. Meta-analysis was precluded by significant heterogeneity. Strongest evidence for successful treatment of depression was demonstrated by psycho-education.
Evidence for the optimal psychologic intervention for depression in HNC patients is limited by the small number of studies examining treatment types, lack of high level of evidence in research methodology, and poor comparability of studies. Future studies should target a standardized assessment and diagnosis as well as evaluation of treatment type.
Analyze the effect of (1) Nutlin-3, a small molecule liberator of p53, on human papillomavirus (HPV) E6 protein-driven oropharyngeal squamous cell carcinoma (OPSCC) cell lines and (2) the response of such cell lines to oxidative stress.
Reproducible drug sensitivity (MTT) and clonogenic assays were performed, with treatments with Nutlin-3 and hydrogen peroxide. Western blots were performed for p53 and MDM2 expression.
Our data show that UM-SCC-47, an oropharyngeal cancer cell line harboring HPV E6, displays no growth or radiation sensitivity to Nutlin-3. As expected from previous work UM-SCC-74A, an oropharyngeal cancer cell line not driven by HPV and harboring wild-type p53, displayed both growth and radiation sensitivity. Similarly, UM-SCC-4, an oropharyngeal cancer cell line not driven by HPV but harboring mutant p53, displayed minimal growth or radiation sensitivity. Early results show that UM-SCC-47 displays significantly greater sensitivity to oxidative stress than cell lines negative for HPV and harboring wild-type p53.
We have shown for the first time that Nutlin-3 has no effect in cells expressing HPV E6. We have also shown that p53-deficient cells have an impaired response to oxidative stress. Such impaired regulation of oxidative stress and metabolism could be exploited in a number of different ways and may have implications for the targeting of cancers that have mutant or no p53, which typically carry a worse prognosis.
Positron emission tomography (PET) scans may highlight areas of increased fludeoxyglucose (FDG) uptake outside the head and neck (HN) region. These may represent a synchronous malignancy or an area of inflammation or infection. Our study aims to investigate the rate of increased FDG uptake PET scans organized for the investigation of head and neck squamous cell carcinoma (HNSCC) and report on the outcome of these FDG-avid areas.
A prospective database of PET scans maintained by the West of Scotland PET Centre was reviewed to identify all scans organized by the head and neck teams between January 2008 and December 2011. Areas with high FDG uptake, above the normal limits for different body tissues at which the radiologists advised further investigation, were noted. Case notes were reviewed and relevant head and neck consultants were contacted to identify further investigations and outcome of these “hot spots.”
Of 299 PET scans during the study period, 40 FDG-avid areas outside the HN and lung were identified, the majority originating in the colon (56%), followed by the prostate and pelvic region. There were 9 confirmed second primary tumors (22.5%), which is a significant proportion of the group, and half of the group had an incidental high standardized uptake value (SUV; negative investigation). Eleven patients were not investigated due to poor health and palliative management.
All increased SUV areas outside the head and neck region should be investigated to identify a synchronous primary which may determine a patient’s overall management and long-term outcome.
(1) Describe the presentation, histopathology, and workup for parapharyngeal space (PPS) neoplasms. (2) Analyze management and long-term oncologic outcomes.
A chart review was performed from 1960-2010 on patients with primary PPS neoplasms treated at a tertiary center with intent-to-cure.
A total of 381 patients were included (160 males; mean, 50.9 years; range, 2 days-89 years). The most common symptom was a neck mass (182/381, 48%). Of the patients, 78.7% (300/381) had preoperative imaging: 44% (167/381) had computed tomography and 41% (156/381) had magnetic resonance imaging. Of the patients, 20.2% (77/381) underwent fine-needle aspiration biopsy. A total of 299 tumors were benign (78.5%), pleomorphic adenomas comprising the majority (151/299, 50.5%). Eighty-two were malignant (21.5%), adenocarcinomas (16/82, 19.5%) being the most common. All patients underwent primary surgical management ± adjuvant therapy. The cervical-parotid approach was the most common (253/381, 66.4%), with mandibulotomies required in 4.5% (17/381). Postoperative cranial neuropathies were identified in 18.7% (70/374); 48.5% (34/70) were related to neurogenic tumors. No perioperative mortalities were reported. Mean follow-up was 89.9 months (N = 345; range: 1 month-42 years). The 5-/10-/ 20-year recurrence-free survival was 93.2%/86.3%/77.9% for benign and 48.2%/38.3%/21.3% for malignant lesions (
While the rate of recurrence for benign PPS lesions is low, these patients remain at risk for recurrence >20 years following surgery. Long-term surveillance should be considered. Patients with malignant lesions are at higher risk for recurrence and have a poor oncologic prognosis. The cervical-parotid approach remains safe and effective for most PPS neoplasms.
(1) Compare outcomes of patients with sinonasal malignancies (SNM) treated with an open resection to patients treated with an exclusively endoscopic or endoscopic-assisted approach. (2) Analyze the differences in surgical complications, length of hospital stay, and margin status between open and endoscopic approaches.
A retrospective review was performed on 102 patients with a pathologically diagnosed T3 or T4 SNM treated definitively at a tertiary care academic center from 1995 to 2012. Oncologic outcomes were determined.
Of the 102 patients, 29 presented with T3 disease while 73 presented with T4 disease. The most common histologic subtype was squamous cell carcinoma (56.9%). Fifty-three patients (52.0%) underwent open resection while 26 (25.5%) underwent an endoscopic or endoscopic-assisted resection. The 5- and 10-year disease-specific survival (DSS) for the 2 surgically treated groups was 67.6% and 65.2%, respectively. There was no significant difference between patients treated with open resection and patients treated with endoscopic resection in overall survival (
Endoscopic and endoscopic-assisted resection of locally advanced SNM in the appropriately selected patient results in similar long-term oncologic control as open resection. There may be a higher rate of CSF leaks during endoscopic resections that contributes to hospital stays similar to those after open resections.
(1) Ascertain the priorities of laryngeal cancer patients concerning oncologic and functional outcomes. (2) Describe how these priorities and professional referral patterns might influence treatment-related decision making.
This cross-sectional survey-based pilot study explored patient preferences and priorities regarding treatment-related decision making for laryngeal cancer using a validated survey instrument. Other questions assessed patient priorities concerning the desired outcomes of their laryngeal cancer treatment and how professional referral patterns (ie, order in which they are seen by different specialists) and desired provider input affect their decisions. Adults with biopsy-proven laryngeal carcinoma were eligible to participate (n = 57; 46% treated surgically, 54% treated nonsurgically).
The 4 most important priorities for patients with laryngeal cancer are oncologic cure (91%), maximizing survival (66%), being able to swallow (44%), and maintenance of natural voice (41%). When considering the level of involvement of surgeons, radiation oncologists, and medical oncologists in their care, patients thought that the specialist who they saw first was most involved in deciding how to treat their cancer (Fisher’s exact, ~χ2(6) = 14.2,
Patient priorities and attitudes coupled with professional referral patterns influence how patients contemplate choices regarding management of their laryngeal cancer. Better understanding of these variables may assist in ensuring that patients’ voices are integrated into individualized laryngeal cancer treatment planning.
Despite the rising prevalence of malignant papillary thyroid carcinoma, locoregional recurrence remains low. Clinico-pathological features associated with recurrence are not well defined. The objective of this study is to describe and evaluate the various pathological features found in patients with recurrent papillary thyroid carcinoma.
A retrospective review was conducted identifying patients who were found to have recurrent papillary thyroid carcinoma between July 2006 and May 2013 at the McGill University Thyroid Cancer Centre.
There was a total of 552 patients with malignant papillary thyroid carcinoma. Over the study period, recurrent disease occurred in 2.0% of patients (n = 11), of whom 10 were pT3N1b and 1 was a pT4aN1. When these patients were compared with the 541 patients who did not have recurrence of their disease, there were significant differences for sex (
In patients with papillary thyroid cancer, sex, tumor size, and extra-thyroidal extension are features frequently found in patients with recurrence. However, positive surgical margins, lymphovascular invasion, lymph node metastasis, and extra-nodal extension were found to be independent predictors of recurrence in this study.
(1) Evaluate the outcomes of patients who underwent total rhinectomies. (2) Give physicians a better understanding of prior treatment modalities, postoperative survival outcomes, and rehabilitation options.
Retrospective chart review of patients who underwent a total rhinectomy during the past 17 years. The variables collected included age, sex, presenting symptoms and signs, tumor size, tumor location, tumor histology, incorrect initial diagnoses, initial treatments, postoperative chemoradiation, and any recurrence of disease, as well as outcomes of prosthetic rehabilitation.
Seventeen patients had squamous cell carcinoma (SCC), 13 patients had basal cell carcinoma, and 2 patients had adenoid SCC. Nineteen patients had postoperative chemoradiation. Eleven patients had recurrence of their disease with an average recurrence time of 20 months. Of the 26 patients fitted with prosthesis, half had specific complaints, the most common of which were bad fit and irritation. At the time of this study, 17 patients were dead, 9 patients were alive, and 6 patients had been lost to follow-up.
Only 8 out of 32 patients had no record of other prior treatment, which speaks to the importance of appropriately managing nasal malignancies. Most patients fitted with a prosthesis were ultimately unhappy in terms of both appearance and comfort, suggesting a need for better rehabilitation options.
In this study, we report a new, less invasive surgical technique in managing preserved parathyroid tissue in patients with secondary hyperparathyroidism who undergo bilateral parathyroid exploration and excision of all 4 parathyroid glands. We report this technique in 4 patients and evaluate their postoperative parathyroid hormone (PTH) levels as a marker to evaluate efficacy.
All 4 glands were first exposed. Superior glands are not possible to transpose and were excised while the inferior glands were mobilized on their pedicles. Once identified, the inferior glands were kept intact until it was determined which gland can be best preserved on its vascular pedicle with adequate length for transposition. This gland was then mobilized through an incision made in the strap muscles, placing it superficial and ventral to the muscles. The majority of the hyperplastic gland was then resected distal to its vascular pedicle. The portion of the gland that was preserved was secured over the strap muscle, making it easily accessible for future exploration and debulking if needed and avoiding a second operative site in the forearm.
Rapid intraoperative PTH assay confirmed adequate removal of hypersecreting parathyroids and was indicative of a curative outcome. All patients exhibited a greater than 90% initial reduction in the PTH level from their baseline and a sustained decrease in postoperative PTH levels well below their preoperative baselines at one month. The percentage mean reduction in PTH at longest follow-up was 94.57%. Importantly, none of the patients exhibited postoperative PTH levels indicative of hypoparathyroidism.
None provided.
To determine if positron emission tomography (PET)-computed tomography (CT) offers any diagnostic advantage over traditional CT neck in assessing the clinically N0 neck in patients with T1 and T2 squamous cell carcinoma (SCC) of the oral cavity.
We performed a retrospective review of patients in the Alberta Cancer Registry who were diagnosed with cT1 or T2N0M0 disease who underwent elective unilateral or bilateral neck dissections. Results of preoperative PET-CT and CT necks were reviewed for number of “suspicious” lymph nodes. Surgical pathology reports were reviewed to obtain the total number of nodes sampled and number of malignant nodes.
Between 2009 and 2011, 148 patients were diagnosed with cT1 or T2N0M0 SCC of the oral cavity. Of these, 62 patients underwent elective neck dissections. Fourteen patients underwent preoperative PET-CT while 48 patients underwent CT neck alone. Based on final surgical pathology, 6 nodes out of 499 nodes sampled were falsely fludeoxyglucose-avid in the PET-CT group while 3 nodes out of 1800 were falsely identified as suspicious on CT neck alone. The overall false positive rate of PET-CT was significantly higher than CT alone (1.2% vs 0.2%,
In patients with cT1 and T2 of the oral cavity and no palpable lymphadenopathy, PET-CT is no better than CT alone for ruling out nodal metastasis and may have a higher false positive rate.
Assess the efficacy of bidirectional esophageal dilatation in the severely strictured esophagus induced by radiation therapy following the treatment of head and neck malignancies.
Retrospective analysis of 5 patients who underwent bidirectional esophageal dilatation for esophageal stricture secondary to radiation therapy for head and neck malignancies over a 5-year period. The parameters of the primary tumor, evaluation of preoperative and postoperative esophageal dysfunction, and complications of the procedure were evaluated to assess its efficacy.
There were 9 episodes of bidirectional dilatation among 5 patients, 3 males and 2 females with a mean age of 63 years. Complete obstruction was demonstrated in 4 patients and severe obstruction was found in one patient during preoperative evaluation. The procedure was uneventful in all but 1 who was found to have postoperative mediastinitis due to microperforations, and healed completely. Four patients had persistent dysphagic symptoms despite post-dilatation video fluoroscopy failing to reveal any significant narrowing of the esophageal lumen.
Combined anterograde and retrograde dilatation of severe chemoradiation-induced esophageal strictures is efficacious in improving luminal patency but ineffective in relieving functional dysphagia.
(1) List the factors that are predictive of non-diagnostic cytology in surgeon-performed ultrasound-guided fine-needle aspiration (FNA) of thyroid nodules. (2) Describe a patient cohort that may benefit from early referral to other clinicians.
Retrospective chart review. Patients included all adults who underwent thyroid nodule FNA by a staff, fellow, or resident otolaryngologist at our center between January 2011 and June 2013. Cytology was interpreted by a staff cytopathologist according to the Bethesda classification system. The predictive factors analyzed were patient age, sex, body mass index (BMI), thyroid gland size, thyroid function, presence of multinodular goiter, presence of Graves’ disease or thyroiditis, nodule size, location, vascularity, echogenicity, calcifications, cystic component, level of performer training, and level of FNA experience. Results were analyzed using chi-squared, Fisher exact test, or unpaired
A total of 190 patients were reviewed, for a total of 301 nodules. The average age was 53 years, with an 88% female predominance. The overall nondiagnostic rate was 23%. Nodules with a predominant cystic component and those less than 1 cm were more likely to yield nondiagnostic cytology (
Cystic nodules and nodules less than 1 cm are more likely to yield non-diagnostic cytology in surgeon-performed thyroid FNA. Caution should be used in trainee-performed FNA for which the nondiagnostic risk is high. These patients may benefit from early referral to other clinicians.
(1) Describe our perioperative experience of primary tracheoesophageal puncture (TEP) with intraoperative placement of voice prosthesis for patients undergoing total laryngectomy (TL) or laryngectomy with partial pharyngectomy requiring supraclavicular artery island flap (SCAIF) reconstruction. (2) Assess TEP voice outcomes in this patient group.
Retrospective chart review of all patients undergoing SCAIF reconstruction following TL or laryngectomy with partial pharyngectomy at a single institution between 2011 and 2013 (N = 14). There were no exclusion criteria.
We identified 7 patients who underwent primary TEP with intraoperative placement of voice prosthesis (mean age = 64.1, 5M:2F). Six patients had prior chemoradiation for laryngeal squamous cell carcinoma. One patient had a dysfunctional larynx from radiation treatment for tonsillar squamous cell carcinoma. Five patients underwent TL and 2 patients underwent TL with partial pharyngectomy. Indwelling 16 French Blom-Singer prosthesis was placed intraoperatively prior to SCAIF reconstruction. There were no TEP-related complications, such as prosthesis displacement or leakage, intraoperatively or in the perioperative period. One patient developed a peristomal pharyngocutaneous fistula. In terms of voice outcomes, 6 patients achieved tracheoesophageal voice production within 10 months after TEP placement, and most occurred earlier (mean time = 2.9 months, SD= 3.1). One patient remained aphonic. Of the 6 patients who achieved successful voice acquisition, 2 required cricopharyngeal segment Botox injections with good response.
Similar to free tissue transfer reconstruction, primary TEP with intraoperative placement of the voice prosthesis at the time of SCAIF reconstruction is safe and effective. Six of 7 patients had successful voice acquisition within 10 months.
(1) Analyze the prognostic factors implicated in survival of patients with recurrent oral cavity squamous cell carcinoma (SCC). (2) Highlight the poor salvage and overall survival rates in this patient population.
Between 1997 and 2006, 235 patients with oral cavity SCC were identified, of which 85 experienced recurrences. Overall survival and prognostic factors were analyzed, including epidemiologic, tumor-specific factors, and surgical outcomes.
Eighty-five of 235 patients experienced recurrence of their primary oral cavity SCC. Only 8 (9.4%) patients have survived, with follow-up ranging from 8 to 14 years. Six of the surviving patients had tongue primaries, while the other 2 had buccal mucosa and hard palate primaries. All 8 surviving patients were staged T1 (1) or T2 (7) and were N0 (6), N1 (1), or N2b (1). Among deceased patients, 9 (11.7%) were staged T3 and 16 (20.1%) T4. Tumor volume (cm3) also varied greatly between surviving (3.97) and deceased (22.14) patients.
Salvage surgery in oral cavity patients remains a difficult clinical problem and our long-term analysis of these patients reveals that most do not survive. Those who survive have lower initial tumor stage, less nodal disease, and smaller tumor volume than the deceased patient group. This data highlights the poor prognosis of these patients and the dire need of different strategies to improve outcomes.
Tracheoesophageal voice restoration (TEVR) has traditionally been described with fistula tract creation, catheter placement, and secondary prosthesis placement. Successful primary prosthesis placement at the time of primary or secondary puncture using a 20 French prosthesis has been previously described. We now wish to evaluate whether 16 French prostheses can be used safely and effectively.
All cases of primary 16 French tracheoesophageal voice prosthesis (TEVP) placements at a large academic medical center were retrospectively reviewed from January 2011 through December 2013. Perioperative complications attributable to device placement were recorded. These included inability to place prosthesis during procedure, intraoperative issues with primary placement, postoperative infection, prosthesis dislodgement, leakage around/through the prosthesis, or inability to obtain voice.
Twenty-two patients received primary placement of a 16 French TEVP. All prostheses were successfully placed, and there were no intraoperative complications. Approximately 18% of patients had a postoperative complication, including leakage through the prosthesis (3 of 22) and prosthesis displacement (1 of 22). These were addressed with prosthesis change and replacement, respectively.
Placement of 16 French TEVPs is effective and safe, with a low rate of complication directly attributable to the prosthesis itself. Therefore, a smaller prosthesis may be primarily placed at the time of TEVR and is preferred over the previously described 20 French prosthesis.
(1) Compare swallowing status in patients receiving a prophylactic gastrostomy (PPEG) tube versus relying on oral intake during chemoradiation (CRT) for head and neck cancer. (2) Discuss prognostic factors associated with gastrostomy tube dependence 1 year after completion of CRT.
The Eastern Virginia Medical School Cancer registry identified patients with a new head and neck cancer diagnosis from January 1, 2001, to July 1, 2008. We excluded patients treated with primary surgical therapy, at an outside facility, and with radiation therapy only. Our final cohort of patients who lived at least 1 year with follow-up was 105. Primary outcomes were oral intake status at 1 year and need for esophageal dilation.
Eighty-one patients received a PPEG, and 24 did not. There was no difference in swallowing function at 6 months (
PPEG tube, Zubrod score >1, and higher T stage were independent predictors for PEG tube dependence after chemoradiation. An approach of initial oral intake with placement of therapeutic PEG due to inability to maintain adequate nutrition by mouth should be considered.
(1) Determine if airway stenting in patients with anaplastic thyroid carcinoma (ATC) is effective in preventing and treating shortness of breath. (2) Analyze whether this procedure affects survival.
Retrospective case note analysis of patients diagnosed with ATC from 2003 to 2013 at a tertiary head and neck unit. Patients diagnosed with ATC were stented with an expandable covered metallic stent, irrespective of airway symptoms, provided they were medically fit and the tumor was >1 cm distal to the vocal cords. Outcome measures were development of dyspnea and survival.
Twelve patients were identified. Tracheal stenting was performed successfully in 4 out of 5 patients; the procedure was abandoned in 1 case due to gross airway distortion. Three of the 4 stented patients did not have airway compromise at the time of stenting; of these 3 patients, 1 did not develop airway compromise at all. The other 2 later developed acute dyspnea due to stent migration as a result of tumor in-growth; these were successfully managed with stent exchange. All nonstented patients died with or from dyspnea. Mean survival postdiagnosis in stented patients was 89 days (n = 4; range, 39-189 days) and in nonstented patients was 91 days (n = 9; range, 8-233).
Tracheal stenting is safe and effective at treating and preventing distressing airway symptoms in patients with ATC. It does not, however, confer any survival benefit.
(1) Analyze radiographic findings of thyroidectomy specimens. (2) Correlate intraoperative radiography to preoperative ultrasound and its guided fine-needle aspiration biopsy, intraoperative impression, and final pathology. (3) Describe a new intraoperative tool to help identify malignant characteristics of thyroid tissue.
Prospective study comprised of consecutive patients undergoing hemi- or total thyroidectomy in a tertiary referral center. This is an ongoing study of patients treated from the months of November 2013 to June 2014. After obtaining ultrasound-guided fine needle aspiration biopsies that were indeterminate or confirmed malignancy, all patients received either a hemi- or total thyroidectomy. Prior to pathologic processing, the specimens were passed off the field and underwent intraoperative specimen radiography (IOSR) by the Faxitron Biovision (Tucson, Arizona), generating a plain radiograph. Radiographic characteristics were analyzed by a surgeon and radiologist and correlated with final pathologic diagnosis. Sensitivity, specificity, positive and negative predictive value, and accuracy of IOSR with regard to final pathology will be reported.
Adequacy of resection of tumors and the presence of microcalcifications are features assessed by IOSR which, when compared with a pathology gold standard, may allow for a intraoperative decision regarding surgery. This technology may reliably detect multifocal microcarcinomas, another indication for total thyroidectomy. This approach may reduce the number of diagnostic hemi-thyroidectomies that require a later completion thyroidectomy.
Intraoperative plain film radiography may be an effective tool in the risk stratification of thyroid specimens and could be used as an adjunctive measure to reduce the need of delayed completion thyroidectomy, depending upon permanent pathology.
(1) Describe the method of harvesting and recognize the versatility of the serratus anterior free flap. (2) Review the use of the serratus anterior free flap for reconstruction after total laryngectomy and for craniofacial defects.
Retrospective case review of 7 cases performed at a single tertiary care institution. PubMed literature review of serratus anterior free flap reconstruction from 1966 to present.
In the 4 patients in whom the serratus anterior free flap was used to reconstruct a total laryngectomy defect, no postoperative wound infections or salivary leaks were identified. The serratus free flap proved to be an effective means of reconstructing the skull base in 2 cases as well as covering a large scalp defect in a third case.
This case series illustrates the benefit of muscle coverage in head and neck reconstruction in both the isolation of the nasal cavity from the intracranial cavity after craniofacial resection and in patients at risk of fistula formation after total laryngectomy. The serratus anterior flap was selected because of its ease of harvest, relatively low donor site morbidity, and adequate bulk. The patients who underwent total laryngectomy did not have evidence of leak, and adequate carotid artery coverage was achieved. Similarly, the craniofacial resection patients achieved adequate cranio-nasal separation and effective coverage of a large scalp defect. The use of a serratus anterior free flap proved to be an excellent choice in the reconstruction of the defects in this series with minimal postoperative morbidity related to both the reconstructive and donor sites.
(1) Estimate the volume of thyroid surgery-related video content readily available to the surgical trainee. (2) Stratify the sources of thyroid surgery-related video content by source (patient, institution, surgeon, or other) and estimate the quality of the surgeon source by related scholarly output.
A search of YouTube, a widely used source of open-access video content, was undertaken using thyroid surgery as the search term. The first 50 hits were analyzed for source. When the video was surgeon-sourced, the surgeon’s name was used in a PubMed author query for thyroid surgery and publications noted.
Approximately 2750 videos were returned using thyroid surgery as the search term. The first 50 hits were stratified by source, assuming the typical surgical trainee would not delve further into the list. The sources were primarily surgeons, followed by patient testimonials and institutions. The surgeons were stratified by related publications listed in PubMed. The majority of surgeons were not published in thyroid surgery-related topics.
Internet video content is an increasingly utilized source of surgical education. Since video content can be posted without peer review or confirmation of veracity, this study measures the variety of sources of thyroid surgery information. Individuals without thyroid surgery publication history posted the majority of surgeon-sourced video content, although this history serves only as a surrogate for an academic career. Trainees and educators alike should critically analyze the quality of video content.
(1) Recognize that failure to identify an ectopic, overly-descended superior parathyroid adenoma may contribute to failed parathyroid exploration. (2) Understand the prevalence of an ectopic, overly-descended superior parathyroid adenoma in both primary and reoperative parathyroid surgery in patients with single-gland primary hyperparathyroidism. (3) Describe the findings that should lead the clinician to suspect the presence of an ectopic, overly-descended superior adenoma.
A retrospective review of patients undergoing curative surgery for single-gland parathyroid adenomas at a single institution was performed. Clinical records, imaging studies, operative reports, and pathology findings were evaluated, and all instances of an ectopic, overly-descended superior parathyroid adenoma were identified. The prevalence of this entity in both primary and revision surgeries was calculated.
There were 270 cases of curative surgery for single-gland parathyroid adenomas during the study period. There were 251 primary operations and 19 re-operative procedures referred from outside institutions. An ectopic, overly-descended superior parathyroid adenoma was present in 9.2% of primary cases and in 21.1% of reoperative cases. While this condition was more common in the reoperative setting (as expected) the incidence in the primary setting was higher than anticipated, and in fact the difference did not reach statistical significance (
An overly-descended superior parathyroid adenoma is common in both the reoperative and primary settings. Recognition and proper treatment of this entity at the initial operation will reduce the need for revision surgery.
The inferior parathyroid glands receive blood supply from the inferior thyroid artery. The anatomic relationship of the inferior thyroid artery and recurrent laryngeal nerve (RLN) can be described in 3 different patterns. We reconsidered the anatomic relationship of these structures and mentioned the method to maintain vascular supply of inferior parathyroid gland during central neck dissection (CND) according to their anatomical relationship.
For removal of fibrofatty tissue in central neck compartment, dissection proceeds along RLN. During the process, surgeons should be careful not to injure the inferior parathyroid gland.
To preserve the inferior parathyroid gland, dissection should proceed along RLN in the medial side of inferior parathyroid gland, if inferior parathyroid gland usually receives blood supply from posterolateral vascular pedicle. In cases in which inferior thyroid artery travels deep to right RLN and right parathyroid gland receives blood supply from posteromedial vascular pedicle, CND should be carefully performed along the lateral side of inferior parathyroid gland to preserve posteromedial vascular pedicle.
To preserve the function of inferior parathyroid gland, the anatomical relationship between inferior thyroid artery and RLN should be understood. The direction of dissection along the RLN should be changed according to their anatomical pattern.
Review the swallowing outcomes of patients undergoing salvage transoral laser microsurgery (TLM) for laryngeal squamous cell carcinoma.
A retrospective chart review was conducted at an academic practice in a regional referral center. Forty-one patients were identified with recurrent squamous cell carcinoma of the larynx after definitive radiation therapy from 2001 to 2013. Twenty-seven patients had glottic recurrences while 14 had recurrences in the supraglottis. Swallowing outcomes were evaluated by the necessity for a gastrostomy tube and the M.D. Anderson Dysphagia Index (MDADI) questionnaire.
The mean value of patients with a preoperative MDADI was 78.25. The mean value of patients with a postoperative MDADI was 73.6. The mean change in patients who completed a pre- and postoperative MDADI was a decrease by 4.9 points. Seventeen patients required a gastrostomy tube either placed during radiation treatment or perioperatively to their TLM procedure. Thirteen gastrostomy tubes were removed, 2 gastrostomy tubes were still in place, and 2 patients died with their gastrostomy tubes in place. All living patients resumed a regular, nonmodified diet.
TLM is a successful surgical option for recurrent laryngeal cancer with acceptable swallowing outcomes.
The authors of the RTOG 91-11 study recently presented long-term outcomes for 3 nonsurgical treatment strategies to preserve the larynx in patients with locally advanced laryngeal cancer. They concluded that concomitant chemotherapy and radiation is optimal for laryngeal preservation; however, 16% of the patients still required total laryngectomies (TL). Additionally, the incidence of pharyngocutaneous fistulas was 30% within this cohort receiving total laryngectomy. We therefore conducted a single center retrospective study of 47 patients treated with total laryngectomy at a tertiary care center from July 2004 to May 2013 to assess the percentage of patients that develop pharyngocutaneous fistula. We propose that the rate of pharyngocutaneous fistula in patients that receive TL will be lower using the technique of flap augmentation compared with the patients that receive TL using the technique of primary closure.
Thirty-two patients received primary closure for TL with a pharyngocutaneous rate of 9.4% (n = 3), and 14 patients received flap augmentation for TL with a pharyngocutaneous rate of 7.1% (n = 1). We also assessed stage of laryngeal cancer; whether the patient received cheomotherapy, radiation therapy, or concomitant radiation and chemotherapy; the muscle used for flap closure; recipient artery and vein; thyroid-stimulating hormone, hemoglobin, intact parathyroid hormone, and albumin preoperative and postoperative values, when available.
The rate of pharyngocutaneous fistula was comparable between the primary closure group and the flap closure group (
Investigate the efficacy of early management of post-thyroidectomy unilateral vocal cord palsy (UVCP) and the clinical utility of the thyroidectomy-related voice questionnaire (TVQ) when planning UVCP treatment.
The study group comprised 48 consecutive patients diagnosed with UVCP after thyroidectomy. Laryngoscopic examination and voice analysis were conducted, and the TVQ was administered pre-thyroidectomy and at 2 weeks and 1, 3, 6, and 12 months post-thyroidectomy. Twenty-five patients with aspiration symptoms and severe vocal difficulties received injection laryngoplasty, and 23 with no aspiration symptoms and relatively mild vocal difficulties underwent voice therapy. We performed a video fluoroscopic swallowing study on each patient 2 weeks after thyroidectomy and 1 month following the procedure.
The average total TVQ scores 2 weeks afterthyroidectomy were 51.92 ± 11.42 in the injection laryngoplasty group and 35.78 ± 12.99 in the voice therapy group. Both subjective and objective parameters improved significantly at 1 month after treatment and continued to improve slowly over the next 12 months (
Early management following timely diagnosis of post-thyroidectomy UVCP can improve symptoms within 1 month. Moreover, application of TVQ will aid clinicians to plan treatment for postoperative VCP patients.
Attendees should be able to (1) learn of an innovative new material for full thickness repair utilizing urinary bladder matrix (UBM); (2) understand the basic mechanism of this procedure; (3) apply this technique and material to daily surgical use.
Over the past 3 years MatriStem (ACell, Inc.) has been used successfully by the author in multiple head and neck reconstructive procedures, including repair of major, full thickness cancer and osteoradionecrosis cases of the scalp, face, and nose, full thickness oral and mandibular bone defects. MatriStem is derived from porcine UBM. Published studies have shown that UBM may recruit progenitor cells to the injury site and stimulate a constructive remodeling response with site-specific tissue. Clinically, MatriStem has shown cost benefits and better patient outcomes compared to other therapies. Previous surgical techniques employed by the author have used various synthetic materials and tissue-derived materials—ranging from cadaveric dermis to bovine tendon—as well as split- and full-thickness autologous skin grafts. However, these techniques did not result in regeneration of full-thickness tissue. These historical results will provide context for the cases to be presented. In this presentation, the author will display many of these clinical experiences.
It has even been possible to regenerate partial bone replacement in radiated bone following partial thickness resection. It has been especially useful in repair of head and neck cancer resection defects.
The use of MatriStem has offered unprecedented solutions to many challenging and complex cases.
(1) Present a case series of patients with hyperthyroidism and thyroid cancer. (2) Look at the clinical characteristics and outcomes of these patients to determine which patients require further investigation.
Retrospective review of case notes of all patients with a histopathological diagnosis of thyroid cancer and biochemical evidence of hyperthyroidism treated at a thyroid cancer center between January 2006 and October 2013.
During the study period, 66 patients were diagnosed with thyroid cancer. Eight patients had biochemical evidence of hyperthyroidism (12.1%). The mean age of these patients was 56.1 years (range, 29-87 years). All patients were female. Of these patients, 3 patients were diagnosed with Graves’ disease, 1 patient with toxic multinodular goiter, and 4 patients with an autonomously functioning toxic nodule (AFTN). Five patients had suspicious features on their preoperative ultrasound. All patients were diagnosed with papillary thyroid carcinoma. The mean size of the tumor in patients with an AFTN was significantly larger than those with Graves’ disease (38.1 ± 7.9 vs 4.6 ± 1.3 mm,
The incidence of hyperthyroidism in thyroid cancer patients is high. In contrast to previous literature, patients with AFTN seem to have more aggressive disease with poorer outcomes when compared to patients with Graves’ disease. Any suspicious nodule associated with hyperthyroidism should be evaluated carefully.
(1) Describe our experience with the use of botulinum A toxin (Botox) in a case series of patients with dysphagia with cricopharyngeal spasm on videofluoroscopy. (2) Systematic review of current literature.
We present a case series of patients with dysphagia refractory to conventional conservative and medical treatment in whom we administered endoscopic injection of 100 mU of Botox into the cricopharyngeus by a single head and neck surgeon using the same technique. Eight patients with refractory dysphagia were treated with 100 mU of Botox injection into the cricopharyngeus. We excluded patients who previously had a surgical intervention to the upper esophagus or pharynx. The change in dysphagia after Botox administration was assessed using the Mayo Dysphagia Questionnaire-30 before and approximately 2 weeks, 3 months, and 6 months after Botox administration and with pre- and post-administration videofluoroscopies.
The Mayo Dysphagia Questionnaire-30 scores improved significantly at all follow-up stages postprocedure. This improvement is reflected in the post-injection videofluoroscopy examinations.
Dysphagia is often difficult to treat. It may be associated with upper esophageal sphincter dysfunction, where conventional treatment, including anti-reflux medication and dilatation, may not be sufficient to provide symptomatic relief. A wide range of surgical interventions with associated morbidity have been described with varying success rates. Our method and experience with endoscopic injection of botulinum A toxin to the cricopharyngeus has shown to be an effective minimally invasive option in those who have been assessed as appropriate for the intervention.
Oncogenic osteomalacia (OO) is a paraneoplastic syndrome seen in tumors of mesenchymal origin that secrete “phosphatonins,” like fibroblast growth factor-23 (FGF-23). They are characterized by hypophosphatemia and osteomalacia. These patients make remarkable recovery once tumors are localized and excised. The authors’ aim was to study retrospectively the clinical, biochemical profile and follow-up of subjects who presented with the features of OO of the head and neck region.
Data of all the patients diagnosed to have OO from 2004-2013 were collected using the computerized database.
Among the total 29 presentations of 27 with OO, 12 (44%) were found to have a histopathologically proven identifiable lesion. Nine (75%) of these were found to be in the head and neck region. The most common presenting symptoms in this subgroup were bone pains (78%) and proximal muscle weakness (56%). Rigid nasal endoscopy, blood pool scan, contrast-enhanced computed tomography, and magnetic resonance imaging of head and neck region picked up 5 out of 6 (83%), 3 out of 7 (43%), 9 out of 9 (100%), and 3 out of 3 (100%) lesions, respectively. All patients underwent surgical excision, of which 56% are in partial and 44% in complete remission. Two patients had a recurrence at the same site after 5 years.
The head and neck region was the most common site where tumor was localized in patients with OO. In all hypophosphatemic osteomalacia, where oncogenic osteomalacia is suspected, nasal endoscopy and imaging of the head and neck region should be done. Surgical excision remains the mainstay of treatment. These patients warrant long-term follow-up as a recurrence can occur several years after the initial response.
(1) Describe key anatomic structures in lateral oropharyngeal wall and tongue base transorally. (2) Determine surgical landmarks to increase intraoperative safety in transoral robotic surgery.
Transoral dissections were performed endoscopically in 5 vascular silicone-injected fresh human cadavers. Anatomic structures were also confirmed with lateral neck dissections.
Tonsillar bed is largely made by superior pharyngeal constrictor muscle and overlying pharyngobasilar fascia. Palatoglossus and palatopharyngeus muscles limit this tonsillar bed anteriorly and posteriorly, forming tonsillar pillars. Stylopharyngeus and styloglossus muscles and stylohyoid ligament run between superior and middle pharyngeal constrictor muscles contributing to inferior tonsillar fossa. These structures are located just medial to facial, lingual, and internal maxillary arteries in parapharyngeal space. Internal carotid artery lies posterolateral to the branches of external carotid artery. Lingual artery injury might occur during base of tongue or inferior tonsil resections. At its origin, the lingual artery is situated deep to middle pharyngeal constructor muscle between stylohyoid ligament and greater cornu of hyoid bone posteriorly. At the tonsil-tongue base junction, it courses lateral and deep to styloglossus muscle. Keeping the resection over styloglossus muscle and stylohyoid ligament will prevent lingual artery injury. The glossopharyngeal nerve is positioned between stylohyoid ligament and styloglosus muscle. Its branches travel posteroinferiorly in inferior tonsillar fossa toward the base of tongue. Lingual nerve is vulnerable to injury as it emerges anterior to medial pterygoid muscle.
A thorough understanding of transoral anatomy is critical for surgeons to perform transoral robotic surgery safely and efficiently.
Determine the usefulness of endoscopic screening methods for detecting synchronous malignancies in patients with head and neck carcinoma.
We retrospectively reviewed the medical records of patients who were diagnosed with head and neck mucosal squamous cell carcinoma (oral cavity, oropharynx, nasopharynx, larynx, hypopharynx) between January 2003 and July 2013 in the Department of Otorhinolaryngology, Head and Neck Surgery, Yonsei University Wonju Christian Hospital.
Among 285 patients who underwent esophagogastroduodenoscopy and bronchoscopy as initial baseline study, 23 synchronous cancers were diagnosed. Esophageal cancer and lung cancer were diagnosed as the most synchronous cancers (10 lesions each), followed by gastric cancer (2 lesions), and colon cancer (1 lesion). Among these 23 patients, positron emission tomography (PET) or PET/computed tomography (CT) was performed in 14 patients. Of these 14 patients, PET or PET/CT detected 7 of the synchronous cancers.
As to their ability in detecting synchronous cancer in head and neck carcinoma, PET or PET/CT showed unsatisfactory detection rate. PET and PET/CT have limitations in the detection of superficial lesions. As initial baseline modality, PET or PET/CT needs supplementary endoscopic studies for the detection of superficial lesions.
(1) Report the outcome of patients with cutaneous squamous cell carcinoma (SCCs) of the head and neck treated with Mohs micrographic surgery in the operating room. (2) Describe the method and benefits of a single operation for extirpation of cutaneous SCC and reconstruction in the operating room with the use of intraoperative Mohs margins.
A total of 104 patients with cutaneous SCCs of the head and neck were retrospectively reviewed in a single-center retrospective study, considering recurrence, metastasis, and death between January 2002 and December 2008. The secondary aim was to describe the demographic and tumor characteristics, type of closure of defect, adjuvant therapies, immunocompromised status, bony or perineural invasion, and regional and local recurrence of SCC cases.
Twenty-one (20%) of the lesions were recurrent SCC. Ten (10%) patients had bony or perineural invasion. Additional extirpative procedures performed by the head and neck surgeons included 8 bone excisions (8%), 2 parotidectomies and neck dissections (2%). Eleven percent had local and 13% had regional recurrences. Nine percent of the total patient population died of disease. Disease-specific survival was 88%.
Mohs micrographic surgery in the operating room for high-risk cutaneous SCC is effective. Using Mohs technique in the operating room permits a combined extirpation and reconstruction as a single procedure. This approach combines Mohs’ proven superior ability to produce clear margins with immediate reconstruction offered by the same surgeon. This offers patients many benefits, and extirpation with forethought of reconstruction offers potential superior outcomes, reduced hospitalizations and anesthetic exposures, and patient convenience.
Electrochemotherapy (ECT) is a cancer treatment based on the transport of chemotherapic drugs such as cisplatin and bleomycin into cell cytosol through depolarization of cell membrane. A locally applied electric field modifies the membrane permeability allowing intracellular accumulation of the chemotherapeutic agent.
Prospective study: 12 patients with head and neck cancer treated with ECT with bleomycin at the ENT Department of Catanzaro teaching hospital from January to December 2013 were recruited. The primary endpoint of the study was ECT efficacy in the neoadjuvant treatment of head and neck cancer. For each patient clinical-anamnestic data were collected in a database and the local tumor control, survival, and effects on quality of life (Health Survey Questionnaire, SF-36 [v1], and Quality of Life Questionnaire, EORTC QLQ-C30, and EORTC QLQH&N35) and pain control (Analgesia Post-Surgery, APS scale) were evaluated. The treatments were performed by Cliniporator IGEA according to the European Standard Operating Procedures of Electrochemotherapy (ESOPE, 2006). Response to ECT treatment was evaluated after 30 days. All patients received postoperative chemoradiotherapy.
Local control and impact on quality of life were evaluated. Six of 12 lesions exhibited a partial response, 4 of 12 exhibited a complete response, and in 2 cases disease progression was observed.
ECT represents a safe and effective therapeutic approach that is associated with clear benefits in terms of quality of life (minimal discomfort, mild post-treatment pain, and short duration of hospital stay).
MYHRE-LAPS syndrome (MLS) is a recently recognized disease caused by a mutation in the SMAD4 gene that alters the transforming growth factor (TGF)–beta pathway. This results in a wide range of pathology including laryngotracheal stenosis, arthropathy, prognathism and short stature, or LAPS syndrome. We present a unique case of MLS associated with both acquired choanal stenosis (CS) as well as subglottic stenosis (SGS) and perform a systematic review of all MLS associated airway pathology.
Single case reviewed via the medical record. Literature review.
MLS was reported in 32 patients, and 5 had clinical airway symptoms. We added the case of a 43F who presented with 9 months of progressive nasal obstruction and was found to have bilateral CS and SGS on endoscopic examination. The patient had no recent airway instrumentation but had two prior operations requiring intubation. Genetic testing revealed SMAD4 mutation consistent with MLS and Losartan was initiated to inhibit TGF-beta signaling. Most patients with MLS develop airway symptoms as a late sequela of disease with a median onset of 22 years old. Attempts to surgically address airway stenosis invariably results in recurrence secondary to robust scar formation. All patients who have undergone surgical management of airway stenosis were tracheostomy dependent (4/4).
MLS is a newly recognized disorder characterized by progressive systemic fibrosis. Airway management is complicated by prognathism, trismus, and limited neck extension as well as invariable restenosis of the airway after instrumentation. Caution should be exercised when surgical intervention is entertained in these patients.
Reduced quality of life after thyroid surgery is multifactorial and may include the need of lifelong different treatments. About 1 in 20 patients experience voice changes, and it is very frequent that these changes may not be caused by neural lesions. The purpose of this study is to describe aerodynamic phonatory features in thyroidectomized patients in order to determine what mechanisms are involved in voice changes in these patients and what are the best rehabilitative options.
We studied 58 thyroidectomized patients with neither apparent neural cause of thyroidectomy-related dysphonia nor recurrent laryngeal nerve injury nor external branch of the superior laryngeal nerve (EBSLN) injury. The patients were asked to produce sustained vowels, syllables, and sentences. Three items were recorded in upright and sitting positions. Afterward, acoustic and aerodynamic measurements were made: fundamental frequency, jitter, shimmer, intensity, harmonic/noise ratio, spectrographic analysis, subglottic pressure, mean transglottic flow, and laryngeal resistance. All measurements were made using Voice Plus from Alamed Corporation software. STATA software was used to analyze variables.
We describe 2 different groups of patients with different aerodynamic pattern in voice production that correlate with voice quality. In 66% of patients there was no change and in 34% the glottal pressure and laryngeal resistance decreased as a result of lower tension in the vocal fold as a consequence of an injury of the EBSLN.
This aerodynamic phonatory pattern that may be understood by objective aerodynamic measurements could be another new sign of EBSLN injury.
Patients with head and neck squamous cell carcinoma (HNSCC) of unknown primary present without voice or swallowing symptoms. This study aims to analyze the impact of radiotherapy on the voice and swallowing function in this subgroup of HNSCC patients.
This was an original cross-sectional study. All patients with treated HNSCC of unknown primary identified from the head and neck cancer database in August 2012 in Greater Glasgow and Clyde had their voice assessed using the Voice Symptoms Scale (VoiSS) and their swallowing function assessed using the MD Anderson Dysphagia Inventory (MDADI).
Questionnaires were sent to 30 patients. A 67% response rate was obtained. There were 5 females and 15 males with a mean age of 61 years (range, 49-81 years). Six patients had no surgical intervention and oncological treatment alone. All patients were free of disease at the time of the study. The mean VoiSS score was 29.45 (range, 4-62) and mean MDADI score was 63.94 (range, 26-100). One patient did not complete the MDADI form so was excluded from this analysis. There was no statistically significant change in patient voice and swallowing function. There was a trend for improved function with longer duration since treatment.
Functional assessment should form an integral part of the assessment of HNSCC patients. This cohort of patients did not have a significant voice and swallowing functional impact secondary to their treatment.
(1) To evaluate the efficacy and safety of coin extraction with the anterior-commissure laryngoscope during apnea in children less than 10 years old. (2) To present the sociodemographic characteristics of this population and analyze the differences in foreign body features. (3) To describe heart rates (HR), minimal O2 saturation, and end-tidal CO2 (ETCO2) during the procedure.
In this retrospective chart review study, consecutive patients with a diagnosis of cervical esophageal coin who underwent this procedure between May 2011 and December 2013 at our institution (n = 59) were evaluated and data analyzed. Age (independent variable) was categorized as ≤1, >1 and <5, ≥5 and ≤10 years old.
The mean and standard deviation (SD) of age was 3.1 ± 2.4 years. The majority were Medicaid participants (87.5%). We successfully removed the coin in 94.9% (n = 59) of our cases with this technique. Among children completing the technique, children ≤1 year of age were more likely to ingest pennies (100%), whereas children ≥5 years old more likely ingested quarters (50%;
In properly selected patients the anterior-commissure apnea technique represents an efficient and secure modality for treatment. If successful, the patient can be safely discharged home after clearance from anesthesia and a PO trial.
It is unknown how acute episodes of phonotrauma affect the recovery of the vocal fold epithelial barrier. The epithelial barrier is characterized by specialized adhesive structures. Our objective was to evaluate the gene expression of junctional complex proteins and inflammatory mediators following phonation-induced trauma in an in vivo rabbit model.
Sixty-five New Zealand white breeder rabbits were randomized to normal (n = 5), modal intensity (n = 30), or raised intensity (n = 30) phonation for 120 minutes. Larynges were harvested at 0 hours, 4 hours, 8 hours, 1 day, 3 days, or 7 days following phonation and compared with normal. Real-time polymerase chain reaction was used to evaluate mRNA expression of occludin, zonula occluden-1 (ZO-1), E-cadherin, β-catenin, interleukin 1β (IL-1β), cyclooxygenase-2 (COX-2), and transforming growth factor β-1 (TGFβ1).
Both phonation groups demonstrated a down-regulation of occludin between 8 hours and 1 day (
Results revealed a critical time point at 8 hours and 1 day in which most junctional complex and inflammatory markers decreased or peaked. Given the mechanical stresses that the vocal folds must withstand on a regular basis, time-dependent changes in barrier and inflammatory gene regulation are critical to understanding vocal fold homeostasis and tissue recovery.
Office-based laryngeal surgery (OBLS) has been shown to be safe and efficacious for many common laryngeal disorders. Despite this, OBLS is not widely adopted by otolaryngologists. This study investigated what barriers exist to OBLS through a survey of practicing otolaryngologists.
A questionnaire was sent to the membership of the Academy of Otolaryngology—Head and Neck Surgery in winter 2013.
A total of 173 otolaryngologists completed the survey. The availability of lasers for OBLS was cited as a major obstacle by 119 out of 173 (75%) of respondents. Reimbursement of disposables and lack of CPT codes for OBLS were the second and third major obstacles noted, respectively (85/173 [53%] and 68/173 [43%]). Reliability of results in the office was less commonly cited as a major obstacle by 24 out of 173 (15%) of respondents.
Organizational and financial considerations continue to be barriers for adoption of OBLS.
Age-related sarcopenia has been recognized in skeletal muscles in relation to the decreased body mass index (BMI). In the swallowing muscles, however, there have been few findings concerning sarcopenia. We studied whether muscle volume of the pharyngeal constrictors decreases with age in healthy adults.
A retrospective review of head and neck magnetic resonance imaging (MRI) of 207 adults (138 males and 69 females, 21-96 years old) examined at the Department of Otolaryngology–Head and Neck Surgery of Kyushu University Hospital between 2010 and 2013 was performed. We measured muscle thickness at 4 levels (mid-mandibular level, hyoid level, vocal fold level, and cricopharyngeal level) with OsiriX software. In each level, measuring points were set at median and 3 points with equal intervals in both sides on axial view of T2-weighted MRI images. Averaged values of constrictor thickness were statistically analyzed in correlation to their age and BMI.
The pharyngeal constrictor muscles appeared thickest at the hyoid level (male: 2.18 ± 0.77 mm, female: 1.79 ± 0.83 mm), which showed no significant correlation to age (
The pharyngeal constrictors appear not to become thin in proportion to age and BMI, unlike skeletal muscles. Branchiogenic swallowing muscles may be tolerable against aging, as compared to skeletal muscles.
(1) Apply transtracheal stimulation (TTS) of the recurrent laryngeal nerve (RLN) for vocal fold closure (VFC) in sensate humans. (2) Characterize tracheal sensory response to electrical stimuli.
Patients with chronic tracheostomies were selected for a “first-in-man” clinical device trial to stimulate the RLN through tracheal tissue for VFC. Etiologies of trach dependence varied, but all subjects had normal laryngeal sensation, vocal cord mobility, and RLN function. Devices were introduced through subjects’ ostomies, and electrodes were subsequently deployed for tracheal contact. Videoendoscopy recorded responses to square wave pulse trains of varying pulse amplitude (PA) and pulse width (PW; 0.5 mA-5 mA and 60 us-500 us, respectively). Subjects were surveyed for sensory changes, discomfort, and pain.
TTS of the RLN successfully elicited VFC in all subjects. The PA threshold for closure (ThPA; at PW = 200 us) ranged from 1.5 mA to 3.5 mA unilaterally, and 1.0 mA to 2.5 mA bilaterally for all subjects except 1 outlier with thresholds of 0.9 mA and 1.2 mA unilaterally, and 0.7 mA bilaterally. PW thresholds (ThPW) ranged from 100 us to 300 us for all subjects (PA = 0.75 × ThPA). All subjects denied pain, but 3 described mild incremental “tingling” that initiated cough or swallow responses only at suprathreshold levels.
TTS initiated arytenoid medialization for VFC in all subjects without pain or significant discomfort. This study presents a novel technique for noninvasive restoration of VFC in humans. Further trials will determine full clinical utility of this device component, individually and in conjunction with components targeting swallow detection and laryngeal elevation for coordinated airway protection.
Office-based procedures, including indirect laryngoscopic surgery and angiolytic laser photocoagulation, have been proposed to treat hemorrhagic vocal polyps. Our previous research documented good treatment outcomes by combining the 2 aforementioned procedures (laser-assisted vocal polypectomy [LAVP]). This study intends to further compare the effectiveness of LAVP with the gold standard of phonomicrosurgery.
This study retrospectively enrolled 50 age-, sex-, and size-matched patients of hemorrhagic vocal polyps treated by LAVP or phonomicrosurgery at a tertiary teaching hospital from January 2012 to October 2013. Treatment outcomes were evaluated before, 2 weeks after, and 6 weeks after the procedures via perceptual rating of voice quality, acoustic measurement of the speech signal, 10-item voice-handicap index (VHI-10), maximal phonation time (MPT), subjective rating of voice quality, and videolaryngostroboscopic evaluations.
Both LAVP and phonomicrosurgery demonstrated significant improvements in most measuring parameters, 2 and 6 weeks postoperatively. Comparative effectiveness demonstrated similar objective outcomes (MPT, VHI-10, perceptual, endoscopic, and acoustic analyses) between LAVP and phonomicrosurgery, while patients who received LAVP reported more symptomatic relief and higher subjective voice quality then phonomicrosurgery 2 weeks postoperatively. Six weeks after the procedures, both objective and subjective effectiveness revealed non-significant differences between the 2 treatment groups.
This study demonstrated that office-based 532-nm LAVP can be an effective, practical, and safe alternative treatment for small hemorrhagic vocal polyps. Patients who received LAVP experienced rapid symptomatic relief with higher subjective effectiveness than phonomicrosurgery, 2 weeks postoperatively. The overall treatment outcomes showed comparable effectiveness between LAVP and phonomicrosurgery.
Evaluate the reflux finding score as a clinical tool to diagnose laryngopharyngeal reflux disease by testing its reliability and reproducibility.
Two scorers independently and blindly reviewed 330 videostrobes of patients that were performed from 2005-2009. Scorers gave each videostrobe a reflux finding score. A chart review was then performed to determine the diagnosis given at the time of the videostrobe, smoking status, whether the patient was treated with anti-reflux medication, and any abnormalities noted on recent esophagoscopy. The reflux finding scores of the 2 scorers were statistically compared for agreement with each other and to the findings of the chart review.
A total of 168 out of 330 patients met final criteria for inclusion in the study. The interrater agreement between the 2 scorers had a weighted kappa of 0.30. The c-statistic scores for correlation of the scorers’ reflux finding scores (RFSs) to the chart diagnosis were 0.554 and 0.609 for scorer 1 and scorer 2, respectively.
The reflux finding score has a fair inter-relater reliability in our study. Blinded rater use of RFS in our study did not correlate well with clinical diagnosis of laryngopharyngeal reflux disease. No statistically significant differences in RFS validity were found based on gender, age, or treatment status.
(1) Recognize the often subtle clinical presentation of complete laryngotracheal separation. (2) Address immediate course of action in the event of a total separation. (3) Describe components of a successful surgical repair.
Over 3 years at a tertiary care center in Las Vegas, Nevada, 3 cases of complete laryngotracheal separation secondary to blunt trauma were successfully treated with prompt surgical intervention. Various surgical techniques were employed, given the complexity and different characteristics of each patient’s presentation, with cartilaginous reduction and fixation favored over soft tissue apposition, along with fenestration tracheostomy procedures to prevent infection of the repair sites. Successful long-term outcome was defined by tracheostomy tube decannulation and lack of multiple tracheal dilations or other tracheoplasty procedures to maintain a patent airway.
All 3 patients initially required a tracheostomy due to airway edema, but each made an uneventful recovery with early capping and tracheostomy tube decannulation. None of the patients necessitated further tracheal procedures, and all had serviceable voice and good swallowing function.
Because of the relative rarity of complete laryngotracheal separations due to blunt trauma, surgical methods for repair are not widely published. We present our experience with the hope that it will assist other surgeons when faced with the challenge of diagnosing and repairing this life-threatening injury.
Tissue engineering of a vocal fold replacement is a promising potential treatment for severe vocal fold scarring. Development and testing of such a tissue construct is an ongoing project. We have previously demonstrated that human adipose-derived stem cells (ASC) can produce a bilayered construct with suitable properties for implantation and phonation. This phase of the project developed a similar construct for pre-clinical animal studies, using rabbit cells.
Rabbit ASCs were isolated, cultured, and embedded in fibrin gels under air-liquid interface conditions and with epidermal growth factor. After culture periods of 1 to 4 weeks, constructs were harvested, sectioned, and examined with immunohistochemistry.
Rabbit cells attached and survived within fibrin gels. Differentiation of the cells to epithelial and mesenchymal lineages was determined by microscopic markers. Deposition of extracellular matrix and basement membrane proteins was also examined.
Rabbit ASCs are suitable for use in a tissue-engineered vocal fold replacement. This model will be used in future implantation trials in rabbits.
Determine and compare the response to treatment with intramuscular botulinum toxin and oral propranolol on vocal tremors, essential and dystonic.
Randomized clinical trial between January 2012 and September 2013. Fifteen patients with vocal tremor were divided into 2 groups: essential and dystonic vocal tremor. Both groups were treated with botulinum toxin in thyroarytenoid muscle (15 units of Dysport unilaterally) and propranolol (80 to 120 mg daily) at different times. Time to “wash out” after injection of 6 months and after propranolol 2 months. Patients underwent self-assessment of vocal improvement, nasofibroscopy larynx, perceptual, and acoustic analysis of voice before and after each treatment. Data were compared according to the type of tremor and treatment and subjected to statistical analysis (significance level of .05).
There was statistically significant improvement in perceptual measure of vocal instability in patients with dystonic tremor after treatment with botulium toxin, compared with propranolol (
The dystonic and essential tremors differ in responses to treatment. The dystonic tremor responds positively to the injection of botulinum toxin into the thyroarytenoid muscle, but not to the use of oral propranolol.
(1) Evaluate whether patients with symptoms of aspiration as assessed by fiberoptic endoscopic evaluation of swallowing (FEES) demonstrate reduced overall muscle weakness, or frailty, as seen by handgrip strength. (2) Determine whether tools such as the Eating Assessment Tool (EAT-20) and Penetration-Aspiration Scale (PAS) correlate with muscle strength as seen by handgrip strength.
Prospective, single-blind study on patients with chief complaints of dysphagia who presented to a tertiary referral center over a 4-month period. Participants completed the EAT-20 dysphagia questionnaire. FEES was performed by administering standardized boluses of 4 different consistencies (thin liquid, nectar, puree, mechanical soft food) and assessing for spillage, penetration, pharyngeal residue, aspiration, and reflux. Patients were additionally scored using the Penetration-Aspiration Scale. Aspirators had a score >5. Overall muscle strength was assessed using handgrip strength measured by hand dynamometry.
Twenty-seven patients with chief complaints of dysphagia were eligible for enrollment. Average grip strength was 25.9 kg, average EAT-20 score was 35, and average PAS score was 3. Six out of 27 patients (22%) were found to be aspirators with PAS >5. Average grip strength for nonaspirators and aspirators was 25.9 kg and 25.6 kg, respectively (
Grip strength does not demonstrate association with dysphagia and risk of aspiration. Frailty may not be strongly predicted by grip strength. Other measures of frailty should be investigated with risk of aspiration.
Identify occupations of new laryngology patients found in high prevalence compared with the occupations of the surrounding general population. Laryngeal disorders have been associated with several occupations, including teachers, singers, and telemarketers. Our study may help identify new groups of patients at risk for laryngeal pathology.
Using our laryngology clinic database, we determined prevalence of occupations in employed new patients from 1993 to 2012 and compared this with data from the Bureau of Labor Statistics for the greater Boston area over the same time period. Proportions with confidence intervals were used to establish statistical significance.
The occupations of 10,119 patients were analyzed. Occupations with statistically significant higher prevalence in laryngology clinic than in the general population included singers, teachers, lawyers, scientists, and clergy. Occupations with lower prevalence included maintenance workers, cleaners, bus drivers, repairmen, and computer programmers.
This study identified several new occupational groups that may be at higher risk of laryngeal pathology because of their relatively higher prevalence in laryngology clinic.
Pharyngocutaneous fistula (PCF) is the most common postoperative complication following total laryngectomy. The aim of this study was to determine the effects of pharyngeal repair time and number of mucosal sutures used on the development of PCF.
The medical records of 47 patients who underwent total laryngectomy were assessed. The pharyngeal repair time and the number of horizontal, vertical, and cricopharyngeal muscle sutures were recorded.
We observed the appearance of PCF in 14 patients (29.8%). The average time for pharyngeal repair in patients without PCF was 22 minutes, 21 seconds ± 5 minutes, and the average number of vertical, horizontal, and cricopharyngeal muscle sutures was 9.54 ± 2.6, 10.84 ± 2.3, and 7.36 ± 2.7, respectively. The average time for pharyngeal repair in patients with PCF was 22 minutes 59 seconds ± 5 minutes, and the average number of vertical, horizontal, and cricopharyngeal muscle sutures was 8.57 ± 2.6, 11.14 ± 2.1, and 8.45 ± 1.9, respectively. The differences in pharyngeal repair time and number of vertical, horizontal, and cricopharyngeal sutures between the 2 groups were not statistically significant (
Surgeons should not be in a hurry when they are repairing esophageal openings, and more sutures should be used in closing the cricopharyngeal muscle to decrease the duration of PCF. Using more vertical sutures when closing the esophagus delays the onset of fistulas.
Report the prevalence and severity of laryngo-pharyngeal symptoms in patients with chronic obstructive pulmonary disease (COPD) compared with controls.
A total of 27 patients with COPD and 13 controls matched according to age and sex were included. Demographic data included age, sex, history of smoking, and history of allergic rhinitis. The Reflux Symptom Index described by Belafsky et al was used. The frequency and average score of each of the laryngopharyngeal symptoms in both the patient group and controls were computed.
The mean age of patients was 61.67 years ± 11.09 years. Sixty-three percent were males and 37% were females. Ninety-two percent were smokers and 11.1% had allergic rhinitis. The mean of total Reflux Symptom Index in patients was significantly higher compared with controls (12.70 ± 7.06 vs 3.00 ± 2.94,
Laryngopharyngeal reflux is more prevalent in COPD patients versus controls. The frequency and severity of laryngopharyngeal symptoms is significantly higher in COPD patients.
(1) Describe a minimally-invasive technique for management of trachea-esophageal fistulae. (2) Analyze outcomes of management of trachea-esophageal fistulae with t-tube placement.
A retrospective case series with chart review was conducted at an academic practice in a regional referral center. Two patients with tracheo-esophageal fistulae who either were not candidates for open surgical repair or refused open surgical repair were successfully managed with a Montgomery T-tube to stent the fistula. Outcome measures included resumption of oral diet, need for further procedures, and fistula size.
Both patients had t-tubes that were sized to stent the fistula and maintain an airway without esophageal stent or tracheostomy. There were no cases of migration or enlargement of fistula. No patients required revision procedures. Fistulae were successfully controlled in all patients, with full resumption of oral intake and maintenance of voice. No patients had closure of fistula.
Montgomery T-tube stenting is a safe and minimally invasive way to manage trachea-esophageal fistulae in patients who are not candidates for open surgical repair. This technique minimizes soilage of the airway with maintenance of voice that is often difficult in management with cuffed tracheotomy tubes. Neither migration nor enlargement of fistula was noted.
The extacellular lipid mediators known as lysophosphatidic acids (LPAs) have been implicated in tumorigenesis of head and neck squamous cell carcinoma (HNSCC). LPAs activate G protein–coupled receptors not only in the endothelial differentiation gene (Edg) family (LPA1, LPA2, LPA3) but also in the phylogenetically distant non-Edg family (LPA4, LPA5, LPA6). The distinct roles of these receptor isoforms in HNSCC tumorigenesis have not been clarified. In the present study, we investigated the effect of ectopic expression of LPA4 in SQ-20B, a HNSCC cell line, expressing a trivial level of endogenous LPA4.
LPA (18:1) stimulated proliferation of SQ-20B cells, but did not affect proliferation of HEp-2, a SCC cell line expressing higher levels of LPA4, comparable to those of with LPA1. LPA-stimulated proliferation of SQ-20B cells was attenuated by Ki16425 and Rac1 inhibitor, but not by Y-27632. Infection with doxycycline-regulatable adenovirus vector expressing green fluorescent protein-tagged LPA4 (AdvLPA4G) abolished LPA-stimulated proliferation in SQ-20B cells with the accumulation of G2/M-phasic cells. Ectopic LPA4 induction further down-regulated proliferation of Ki16425-treated SQ-20B cells, of which down-regulation was partially recovered by LPA. Ectopic LPA4 induction also down-regulated proliferation of Rac1 inhibitor-treated SQ-20B cells; however, LPA no longer recovered it. Finally, LPA-induced cell motility was suppressed by ectopic LPA4 expression as well as by Ki16425, Rac1 inhibitor or Y-27632.
Our data suggest that LPA4 signaling potentially modulates malignant behaviors of SQ-20B cells. LPA signaling, which is mediated by both Edg and non-Edg receptors, may be a determinant of malignant behavior of HNSCC and could therefore be a promising therapeutic target.
(1) Appreciate the use of laryngeal manipulation as treatment for perceived dysphagia resulting from excessive paralaryngeal muscle tension. (2) Describe the patients likely to have symptomatic improvement.
A retrospective review identified patients from 2007-2011 with laryngeal manipulation for muscle tension-caused dysphagia in an academic otolaryngology practice. Subjects with dysphagia not attributable to anatomic cause who attended therapy twice or more had symptoms, demographic information, treatment, and response to therapy abstracted.
Thirty-five subjects were included, consisting of 28 women and 7 men. Race was recorded as black (11), Hispanic (8), white (9), and other (7). Improvement in dysphagia was seen in 25 (71.4%, 95% confidence interval 53.7% to 86.4%). No significant differences were seen in improvement based on sex (
We found improvement with laryngeal manipulation among individuals with muscle-tension-caused dysphagia. No significant differences in efficacy were seen among racial and sex subgroups. A model with age and number of sessions was significant. A prospective trial of this therapy appears warranted.
(1) Describe techniques to appropriately anesthetize the larynx to facilitate complete resection of large granulomas in an unsedated patient. (2) Implement transnasal and transoral techniques to resect granulomas in conjunction with fiber-guided lasers.
This is a retrospective review of patients undergoing resection of large symptomatic vocal process granulomas in the office environment. Three patients were treated with resection of granulomas with primarily transoral excision, with transnasal resection and laser ablation utilized as adjunct techniques. Botox injections were also used in a subset of patients to optimize healing. All procedures were documented with video. All patients received only topical anesthesia with no periprocedural sedation.
All patients had resolution of their granulomas or self-reported their vocal function to have returned to baseline after healing.
Large vocal process granulomas can be treated in a single session in the laryngology procedure suite on the unsedated patient. An excellent outcome can be attained with readily available technology to include rigid endoscopy, flexible tranasal laser laryngoscopy, and Botox injections. Consideration should be given to treating these bulky granulomas in the office-based environment.
Arytenoid adduction surgery for the unilateral vocal fold paralysis is usually carried out under intravenous sedation because improvement of the voice evaluable during surgery. In patients preferred for surgery under general anesthesia due to their physical or mental condition, we selected general anesthesia using laryngeal mask mechanical ventilation, and we confirmed the location of the vocal fold during surgery using a flexible fiberscope. To evaluate this procedure of anesthesia, we compared outcomes of the adduction surgeries between intravenous sedation and general anesthesia.
From September 2012 to August 2013, adduction surgeries were performed in 17 cases under intravenous sedation with spontaneous breathing, and in 5 cases under general anesthesia using laryngeal mask. Pre- and postoperative maximum phonation time (MPT), mean flow ratio (MFR), and voice handicap index-10 (VHI-10) were evaluated.
MPT, MFR, and VHI-10 were remarkably improved in all adduction surgery with intravenous sedation cases. In the general anesthesia group, improvement of the factors was also recognized in most cases, but not in all.
Adduction surgery under general anesthesia with laryngeal mechanical mask ventilation is a useful tool for the unilateral vocal fold palsy patient. However, even though we checked the position of the vocal fold in surgery, the efficacy of the surgery is not guaranteed in a few cases because the actual voice cannot be evaluated in general anesthesia.
(1) Present a case of metastatic calcinosis of the true vocal cords. (2) Discuss the pathogenesis, diagnosis, and treatment strategies for this condition.
This is a case report of a 52-year-old male with a history of end-stage renal disease and tobacco abuse who presented to clinic with complaints of dysphagia, cough, and subtle voice changes. Transnasal fiberoptic laryngoscopy revealed bilateral patches of leukoplakia on the anterior third of the vocal cords. After a 3-month period of conservative management with a proton pump inhibitor and serial scope examinations, the lesions were noted to be slowly enlarging. It was determined that an excisional biopsy should be performed to rule out malignancy. The patient underwent micro-suspension direct laryngoscopy with microflap excision of the bilateral vocal cord lesions.
Surgical pathology revealed benign squamous mucosa with calcinosis, parakeratosis, and submucosal hyalinization. These findings were characteristic of metastatic calcification. Review of the patient’s medical records confirmed ongoing phosphorous dysregulation. Metastatic calcinosis of the true vocal fold is a very rare finding, with only 2 other reported cases in the literature.
In patients suffering from end-stage renal disease, dysregulation of calcium and phosphate levels may lead to deposition of calcium in many types of soft tissue, including the true vocal cords. Examination findings may mimic dysplastic lesions, and this diagnosis should be considered in patients with chronic kidney disease.
Investigate the prevalence of phonatory symptoms, perceptual, acoustic, and aerodynamic findings in patients with asthma compared to a control group.
A total of 50 subjects, 31 asthmatic and 19 control subjects matched according to age and sex, were enrolled in this study. All subjects were asked about the presence or absence of cough, dyspnea, respiratory failure, dysphonia, degree of vocal fatigue, and phonatory effort. Perceptual evaluation, acoustic analysis, and aerodynamic measurements were also performed. Patient self-assessment using the Voice Handicap Index 10 was reported.
The mean age of patients was 43.5 years with a female to male ratio of 2:1. There was a statistically significant difference in the prevalence of dysphonia between the 2 groups (32.3% vs 5.3%,
Phonatory symptoms are significantly more prevalent in patients with asthma compared to controls.
While there is a well-documented association between intubation and laryngeal granuloma development, not every intubation results in granulomas. We identify patient factors associated with the development of laryngeal granulomas after endotracheal intubation and analyze the efficacy of different treatment interventions on granuloma resolution.
A retrospective review of the medical records of patients treated for laryngeal granulomas after endotracheal intubation at 2 tertiary care centers between 2005 and 2013 was performed. Medical comorbidities, peri-intubation medications, and treatment modalities and outcomes were recorded. Fisher exact test was used to compare patients with laryngeal granulomas to matched control patients who did not develop granulomas after intubation. Efficacy of treatment modalities was also analyzed.
Twenty-three patients with laryngeal granulomas after intubation were identified and compared with controls. There was a statistically significant association between the development of laryngeal granulomas and hypertension/cardiovascular disease, obesity, renal disease, and gastroesophageal reflux (
Patient comorbidities likely play a role in the development of laryngeal granulomas after endotracheal intubation, while peri-intubation medications and tobacco/alcohol use do not appear to significantly impact development. Surgical excision was most effective in achieving remission.
Recent progress in phonomicrosurgical technique and equipment enabled one to precisely differentiate the subepithelial (type1) and subligamental (type2) cordectomy concept as needed. The purpose of this study was to compare postoperative glottal function and voice-related quality of life (QOL) between these 2 surgical concepts against laryngeal leukoplakia.
From January 2007 to August 2013, 42 consecutive laryngeal leukoplakia patients had excisional biopsies using type1 procedures. Of these, cancer patients (n = 10) had additional type2 laser surgeries. Furthermore, some severe dysplasia/carcinoma in situ patients (n = 11) preferred additional type2 surgery aiming at relatively safe surgical margins. Sequential pre- and postoperative measurements of Grade, Roughness, Breathiness, Asthenia, Strain (GRBAS) scale and evaluations of laryngeal videostroboscopic images were performed. Acoustic measurements and voice-related QOLs (VHI and V-RQOL) were examined at the patients’ last visits. All data were compared between type1 and type2 groups.
Vocal quality was well-preserved in type1 group after surgery. Although immediate postoperative deterioration of GRBAS score was observed in type2 group, vocal recovery was obtained in 6 months to present no significant difference compared with type1 group. Impaired glottal closure and pliability were observed in both groups after surgery. While videostroboscopic findings of type1 group recovered to normal in 3 months, impaired glottal findings remained for 1 year in half of the type2 patients. Moreover, voice-related QOLs were significantly better in type1 group.
Our study proved that advanced phonomicrosurgical technique and equipment could offer a well-preserved vocal quality even in the type2 group. However, subjective voice-related QOLs were better in the type1 group with superior videostroboscopic findings.
Endoscopic stapler Zenker’s diverticulotomy (ESD) has become a well-accepted treatment of Zenker’s diverticulum (ZD). A small percentage of ZDs may recur after ESD. We sought to evaluate the technical feasibility, safety, and effectiveness of revision endoscopic stapler diverticulotomy (RESD) for recurrent ZD.
A retrospective case study conducted in Tel-Aviv Sourasky Medical Center. The records of all patients who underwent ESD between the years 2002 and 2013 were reviewed. The records of patients who underwent RESD were identified and screened for primary surgical history, symptoms of recurrent ZD, time to recurrence, intraoperative and postoperative RESD course, complications, and symptom resolution.
Eighty-nine ESD were performed. Twenty were RESD for recurrent ZD and 69 were primary ESD (PESD). Nine RESD were performed for recurrent ZD after open trans-cervical Zenker’s diverticulectomy, 10 ESRD were performed for recurrent ZD after ESD, and 1 initial surgical approach was unknown. Mean patient age at revision was 66.1 years and mean time from first operation for ZD to RESD was 4.7 years. Average ESRD surgery time and hospital stay were 21.4 minutes and 2.8 days, respectively. Endoscopic stapling of the ZD was achieved in 19 of 20 RESD. Relief of symptoms without recurrence was achieved after 18 RESD. Four RESD patients experienced minor postoperative complications. We found no significant differences between the RESD and PESD groups regarding age, operative time, technical feasibility, hospital stay, and complication rate (
RESD for ZD is technically feasible, safe, and effective. Results compare to PESD.
Investigate phonatory symptoms and acoustic and aerodynamic findings in patients with chronic obstructive lung disease (COPD) compared to a control group.
A total of 40 subjects, 27 COPD and 13 control subjects matched according to age and sex, were enrolled in this study. All subjects were asked about the presence or absence of dysphonia, degree of vocal fatigue, and phonatory effort. Perceptual evaluation, acoustic analysis, and aerodynamic measurements were also performed. Patient self-assessment using the Voice Handicap Index 10 was reported.
There was a statistically significant difference in the prevalence of dysphonia between the 2 groups (12% vs 0%,
Dysphonia is significantly more prevalent in patients with COPD compared to controls.
Some authors have reported effects of some materials used for injection. Their effects that reduce the size of glottal gap do not last because the materials are usually absorbed. Thus, patients with deficient glottal closure must be repeatedly injected. To reduce the number of treatments, we injected basic fibroblast growth factor (bFGF) into our patients. The purpose of this study was to examine the effect of bFGF injection by high-speed imaging and acoustic analysis.
Fifteen patients (8 men and 7 women, mean age 65 years) were enrolled in this study. Four or 8 µg of bFGF were injected into each treated vocal cord. The injection was made into the unilateral or bilateral vocal cord according to the size of glottal gap. All patients were followed up every 3 months. Using high-speed imaging and PS77E, we analyzed the following factors: KEA (kimograph edge analysis), GAW (glottal area wave form), phase shift analysis, PPQ (period pertubation quotient), APQ (amplitude perturbation quotient), MFR (mean flow rates). The effect of the treatment was assessed by high-speed imaging and acoustic analysis.
Data both from the imaging analysis and acoustic analysis showed significant improvement in all subjects after 6 months. No allergic or long-term adverse effects were noted.
The result of this study suggests bFGF may be effective long-term and safe as a regenerative agent for aged vocal folds.
Although most of the laryngeal leukoplakias are temporal inflammatory lesions in non-smokers, some patients represent serious histopathologies to require careful management. The purpose of this study was to clarify unique clinical features of the patients who require cautious care in this low-risk group.
One hundred fifty-four consecutive patients referred to our institution with laryngeal leukoplakia from June 2006 to May 2013. Of these, 24 patients without smoking history were incorporated in this study. Retrospective chart reviews and the re-evaluations of video-taped laryngeal images were performed. Sequential change of vocal quality (Grade, Roughness, Breathiness, Asthenia, Strain scale) was assessed in each patient. Timings to show improvements of laryngeal images were studied in the patients with spontaneous disappearances of leukoplakias (n = 12). Furthermore, excisional biopsies were performed on 12 patients and their histopathologies and vocal/stroboscopic characteristics were compared with each other.
Spontaneous disappearances of the lesions were observed 4.6 months after referral to our hospital on average, and these patients presented vocal quality of G1 or G0 at their first visits. Additionally, gradual recoveries in their glottal closure and/or pliability of diseased vocal folds were observed in this group. Furthermore, patients with histopathology of severe dysplasia/cancer presented with either (1) no improvement in their G2 voice for 1 month, (2) incomplete glottal closure coupled with abnormal pliability of diseased vocal folds for 1 month, or (3) abnormal pliability of diseased vocal folds for 4 months.
Our analyses identified several specific findings to predict serious pathology in laryngeal leukoplakia patients without smoking history.
Ascertain if there is an association between the pitch and loudness of tinnitus and its impact on patient quality of life.
A cross-sectional study comprising 156 patients (mean age, 57.95 ± 12.53 years) with chronic unilateral disturbing tinnitus was conducted between September 2003 and January 2014. Acufenometry was used to measure the pitch and loudness of tinnitus. We evaluated the impact of the annoyance caused by tinnitus using tinnitus handicap inventory (THI) and the visual analog scale (VAS). Statistical analysis was performed using Pearson’s correlation test.
Overall, 27.3% of the patients evaluated had presbycusis, while 12.2% had noise-induced hearing loss (NIHL) and 15.1% had Ménière’s disease. The correlation coefficient observed between the loudness of tinnitus and THI was
The findings of this study did not reveal a statistically significant correlation between tinnitus characteristics and its impact on patient quality of life. However, a weak negative relationship was observed between the tinnitus pitch and the age of the patients.
Some patients with dizziness often show psychological distress. However, the association of vestibular deficit with psychological symptoms remains controversial. Thus, we investigated the incidence of high depression and anxiety index in patients who complained of dizziness, their dizziness severity, and the distribution of disease to induce dizziness.
In 562 patients with dizziness, dizziness and the psychological distress of all patients were measured using the Korean versions of the Dizziness Handicap Inventory (DHI), the Beck Depression Inventory (BDI), and the Spielberger State-Trait Anxiety Inventory (STAI). We examined the incidence of patients having high depression and anxiety using a cutoff value (BDI ≥21, STAI ≥57). We divided patients into a high psychological distress index group and a moderate to low index group on the basis of cut-off value and compared the type of disease and DHI score between the 2 groups.
The incidence of high BDI and STAI scores were 11% and 13.5%, respectively. The high BDI and STAI group showed the higher DHI scores, including functional, emotional and physical subscales, and the higher STAI and BDI scores, respectively. The mean age, sex and the distribution of the type of disease between high psychological distress index group and moderate to low index group showed no difference.
Of patients with dizziness, about one-tenth have serious psychological distress, various vestibular diseases, and more dizzy symptoms. Thus, we should keep in mind the psychological factor in dizzy patients and the necessity of psychological support in the patients.
Transoral laser microsurgery is considered one of the best techniques for the treatment of early stage glottic cancer. But voice outcome and quality of life (QOL) after laser cordectomy has not been fully evaluated. The aim of this study is to evaluate the voice outcome and QOL after transoral laser cordectomy in glottic cancer.
We studied 43 glottic cancer patients who underwent transoral laser cordectomy from January 2002 to December 2008, retrospectively. We evaluated objective and subjective voice outcome using acoustic analysis, aerodynamic study, and voice handicap index (VHI). We also assessed QOL using EORTC QLQ-C30/H&N35 questionnaire at preoperative and postoperative 6 to 12 months. We analyzed the correlation between voice outcome and QOL according to the types of laser cordectomy.
Postoperative harmonic to noise ratio, maximum phonation time, and VHI score was significantly improved from preoperative scores in patients who underwent type I-II cordectomy (
Objective and subjective voice outcome after laser cordectomy showed favorable results, especially in patients who underwent Type I or II laser cordectomy.
Study the correlations of endolymphatic hydrops and vestibular symptoms with otosclerotic foci.
Comparative study of human temporal bone histopathology. In addition to areas of the stria vascularis and spiral ligament and the presence of endolymphatic hydrops, locations and degree of endosteal involvement and size of otosclerotic foci were examined in 132 temporal bones from 95 subjects with otosclerosis. The degree of endolymphatic hydrops was classified as mild, moderate and severe.
Fifty temporal bones (37.9%) from 39 subjects with otosclerosis had a histopathological finding of endolymphatic hydrops. The most common location of endosteal involvement was the endosteum of the perilymphatic space of the vestibule. In terms of locations and degree of endosteal involvement and size of otosclerotic foci, there was a significant increase in subjects with otosclerosis with endolymphatic hydrops compared with subjects with otosclerosis without endolymphatic hydrops. Twenty five subjects (26.3%) had a documented history of vestibular symptoms in patients with otosclerosis. In addition to the presence of endolymphatic hydrops, locations and degree of endosteal involvement and size of otosclerotic foci were significantly greater in subjects with otosclerosis with vestibular symptoms compared with subjects with otosclerosis without vestibular symptoms.
Endolymphatic hydrops is more common than previously realized in patients with otoslerosis. The common association of these 2 otologic conditions encourages researchers. Clinicians should keep in mind the common association of these 2 otologic conditions when encountering a patient with either of these conditions.
(1) Determine if cervical vestibular evoked myogenic potentials (cVEMPs) and ocular vestibular evoked myogenic potentials oVEMPs are good electrophysiological examinations to represent the degree of cisplatin-induced otolith toxicity. (2) Examine if D-methionine (D-met) pre-injection protects the otolith organs against cisplatin-induced changes of enzyme activities and oxidative status.
Guinea pigs were intraperitoneally injected with sterile 0.9% saline alone, cisplatin (5 mg/kg) alone, D-met (300 mg/kg) alone, or D-met (300 mg/kg) 30 minutes before cisplatin (5 mg/kg) in combination, once daily for 7 consecutive days. Each animal was given the oVEMP and cVEMP tests before and after treatment. Changes in otolithic biochemistry, including membranous Na+, K+-ATPase, and Ca2+-ATPase, lipid peroxidation (LPO), and nitric oxide (NO), were also evaluated.
In the cisplatin-treated guinea pigs, the mean amplitudes of cVEMP and oVEMP tests were significantly (
The cVEMP and oVEMP tests were feasible for the evaluation of cisplatin-related otolith dysfunction. The D-met–mediated improvement in otolith function correlated with a significant attenuation of increased oxidative stress and reduced ATPase activities.
Frailty is a state characterized by decreased physiologic reserve and weakness that is associated with poor health outcomes. Whether hearing impairment, which is associated with physical and cognitive decline, is associated with frailty, is unknown.
We analyzed 2109 individuals 70 years and older in the 1999-2002 cycles of the National Health and Nutrition Examination Survey (NHANES). Hearing impairment was measured by self-report (good, little trouble, lot of trouble). Frailty was defined as the presence of at least 3 of the following: 5% unintentional weight loss in the past year and/or body mass index <18.5 kg/m2, slow walking speed, weakness, exhaustion, and low physical activity. Logistic regression models were adjusted for demographic characteristics, cardiovascular risk factors, hearing aid use, and health status.
Among all individuals, self-reported hearing impairment was significantly associated with frailty in fully adjusted models (odds ratio [OR] 1.68 [95% confidence interval {CI} 1.00, 2.82]). Analyses stratified by sex demonstrated that this association was observed in women (OR 3.79 [95% CI 1.69, 8.51]) but not men (OR 0.85 [95% CI 0.44, 1.66]).
In these cross-sectional analyses, self-reported hearing impairment was significantly associated with frailty in women. Further research using objective hearing measures and longitudinal assessment of frailty are needed.
Several contemporary bone-anchored hearing aid (BAHA) surgical techniques have been described with the common goal of minimizing soft-tissue reduction, which may benefit patients, surgeons, and audiologists alike. Recently, the hydroxyapatite coated Cochlear BA400 abutment was introduced, the first designed specifically for soft tissue preservation. We present our early experience of this system with corresponding patient-reported outcomes.
Data were collected prospectively on the first 25 patients implanted with the BA400 system at our institution (February-September 2013). The Glasgow Benefit Inventory (GBI) was subsequently used to evaluate patient-perceived quality of life in all patients 4 months following sound processor fitting.
Mean patient age was 61 years (range, 23-91 years). BAHA was indicated for single-sided deafness in 6 cases (24%) and for conductive or mixed loss when a conventional aid was contraindicated in the remainder. Procedures were performed under local anaesthetic in all but 1 case. Mean operating time was 14 minutes (range, 9-22 minutes). Four patients (16%) suffered implant site soft tissue reactions which were all successfully managed conservatively and graded as follows: Holger’s grade 1 (n = 2), 2 (n = 1), and 3 (n = 1). No other complications were observed. Respective overall, general health, social support, and physical health GBI benefit mean scores were +33 (95% confidence interval [CI]; 27-39), +46 (95% CI; 37-55), +15 (95% CI; 5-25), and 0 (95% CI; –8 to 8).
Our data support use of the soft tissue preserving Cochlear BA400 implant system, with shorter operating times, comparable soft-tissue outcomes, and favorable patient-reported quality-of-life when compared with conventional BAHA implantation techniques.
Analyze the effects of betahistine on tinnitus in patients with Ménière’s disease.
Retrospective review of the effects of betahistine on tinnitus in patients with Ménière’s disease treated from January 2010 to January 2014. Patients included in this study received therapy with 8 to 64 mg/d of betahistine. Clinical improvement in tinnitus symptoms was defined as a partial or total response.
A total of 764 patients with Ménière’s disease were identified in our electronic database. Forty seven of these patients were treated with betahistine for vestibular symptoms. Duration of therapy varied from 1 week to 4 years. Twenty-seven patients were successfully contacted for a phone interview or via email. Twenty-three patients reported tinnitus as a symptom. Only 13 of the 23 reported tinnitus as a disturbing symptom. One patient stopped betahistine therapy after the first week because of palpitations, another stopped the betahistine after 2 weeks because of increased dizziness and nausea, and a third briefly stopped treatment while using albuterol for an episode of bronchitis. Only 3 patients had clinical improvement of their tinnitus (3/23; 13%). Sixteen patients reported improvement in their vestibular symptoms (16/27; 59.2%).
Betahistine does not significantly reduce tinnitus in Ménière’s patients treated for vestibular symptoms. Improvement in tinnitus may occur in some patients.
The Bonebridge implant (BBI) is a bone-conduction hearing implant with a relatively large floating mass transducer (FMT), which is seated within a bony well. This well is drilled in the mastoid process and the FMT is anchored onto the bony cortex with screws on the side of the well. The location of the well has to avoid vital structures, such as the posterior canal wall, the dura mater of the middle cranial fossa, and the sigmoid sinus. The size of the well must be sufficient to accommodate the size of the FMT. This becomes more important in patients with contracted mastoids.
This case series aims to review the use of image guidance localization (IGL) in planning the site of the well. Under general anaesthesia, the patient was positioned supine, with the head turned away from the site of the BBI. Local anaesthetic was administered and a postauricular incision was made and deepened down to bone. The subperiosteal flap was elevated and the surgeon determined the location of the FMT, with the help of the IGL. A conservative cortical mastoidectomy was performed to create a well for the FMT to sit in. A subperiosteal pocket for the receiver coil was created posterior-superior to the well.
Five patients underwent BBI surgery with IGL. Rapid and accurate localization of the site of the well for the FMT was possible in each case.
The authors recommend IGL as a safe, rapid, and reproducible technique in localization of the site for the well of the BBI.
Describe in children: (1) cholesteatoma growth patterns; (2) conductive hearing loss severity; (3) contralateral ear (CLE) findings.
Cross-sectional study. Videotoscopies of 129 pediatric patients at a tertiary care hospital were analyzed for cholesteatoma growth patterns, air-bone gap, and CLE otoscopic findings. Data were compared with the chi-squared test and analyzed using SPSS.
The mean patient age was 12.4 ± 4.36 years. The cholesteatoma growth patterns were anterior epitympanic cholesteatomas (5.4%), posterior epitympanic (21.7%), posterior mesotympanic (43.4%), 2 routes pattern (17.1%), and undetermined (12.4%). The pure tone average air-bone gap (PTA-ABG) was ≤20 dB in 8.7% of patients, between 20 to 40 dB in 43.4% of patients, and ≥40 dB in 47.9%. The CLE was normal in 34.9% of patients and had moderate or severe tympanic membrane (TM) retractions in 46.5%, TM perforation in 7.8%, and cholesteatoma in 10.9% of patients. The CLE disease prevalence was similar between the groups, except in anterior epitympanic group, which had normal CLE (
Posterior mesotympanic cholesteatomas were the most prevalent in the study population. Most patients had a PTA-ABG greater than 20 dB, and the most prevalent CLE abnormalities were moderate or severe TM retraction and cholesteatoma. The CLE of patients diagnosed with anterior epitympanic cholesteatoma were normal, suggesting a probable congenital origin.
To assess the anatomic and audiometric results of type I cartilage tympanoplasty and to compare them with the results of type I fascia tympanoplasty in children.
A retrospective chart review was performed of pediatric patients who underwent primary type I tympanoplasty with cartilage or fascia at a tertiary academic center between July 2007 and July 2013. Patients were excluded who underwent concurrent mastoidectomy or ossicular chain reconstruction. Graft acceptance rates were compared between the 2 groups. In addition, preoperative and postoperative audiometric results were compared.
One hundred twenty patients were identified for inclusion into the study. The mean follow-up time was 1 year. There was no significant difference between the cartilage and fascia tympanoplasty groups in terms of graft acceptance rate. Audiometrically, there were also no significant differences between the 2 groups in terms of mean pure tone average and speech discrimination score. A significantly higher percentage of patients who underwent cartilage tympanoplasty had a type B tympanogram (
In children, cartilage and fascia tympanoplasty have similar results in terms of graft acceptance and hearing outcomes. This study corroborates the findings of other studies, that cartilage tympanoplasty is a safe and effective technique in children.
Determining cochlear implant candidacy status requires a specific sentence-level testing paradigm in best-aided conditions. Correlation of the findings on routine audiometry with those of formal cochlear implant (CI) evaluation has not been performed. Our objective was to determine if findings on routine office-based audiometry could predict the results of a formal CI candidacy evaluation.
The charts of all adult patients who were evaluated for CI candidacy at a tertiary care center from June 2008 through June 2013 were included. Routine, unaided audiologic measures (pure-tone hearing thresholds and recorded monosyllabic word recognition test [MWRT] results) were then correlated with best-aided sentence-level word discrimination test (SWDT) results using either the Hearing in Noise Test (HINT) or AzBio sentences.
The degree of hearing loss at 250 to 4000 Hz significantly correlated with SWDT results. Additionally, 87% of patients who scored <30% in MWRT qualified for implantation using HINT sentences. Similarly, in patients whose MWRT scores were <35%, 81%, and 93% met CI candidacy criteria when using AZBio sentence testing in quiet and noise, respectively.
Routine office-based audiometry can be used to identify patients who would highly likely meet CI candidacy upon formal testing. For example, a pure tone threshold of ≥55 dB at 250 Hz and a MWRT score of ≤35% when evaluating using AzBio sentences collectively identifies a patient who is likely to meet candidacy criteria. Using these predictive patterns during routine audiometry may assist hearing health professionals in deciding when to refer patients for a formal CI evaluation.
(1) Analyze our own cases and those in published reports involving cochlear implantation (CI). (2) Determine the factors affecting outcome in patients with common cavity (CC) deformity.
We reviewed the English and Japanese literature published from January 1995 to December 2013 using the keywords “CC,” “CI,” and “cochlear malformation.” We included cochlear implanted CC patients whose records on occurrence of cerebral spinal fluid (CSF) gusher, facial nerve stimulation (FNS), number of inserted and actively used electrodes, or hearing levels before or after CI were available.
A total of 72 cochlear implanted CC patients were identified from 11 reports, including 5 patients from our institution. Individual hearing results as monosyllable and word scores were reported in 9 and 15 patients, respectively. Monosyllable hearing levels were greater in patients inserted with ≥20 electrodes and in those younger at time of CI. CSF gusher occurred in 18 (32%) of 57 patients, and FNS occurred in 12 (44%) of 27 patients.
Individual data are important in assessing the outcome after CI in patients with CC because the outcomes vary significantly. Although there have been several reports, only a few have reported efficient data to discuss the propriety of each operation. Younger age at CI and greater number of inserted electrodes were associated with better outcome following CI in patients with CC. However, additional data are needed to confirm our findings.
Anteriorly located congenital cholesteatoma is a silent disease in the pediatric population. In most cases, they are diagnosed incidentally by endoscopic examination of tympanic membrane. The aims of this study were to evaluate the clinical features and natural courses of congenital cholesteatoma, especially anteriorly located group.
From 2000 to 2012, 117 patients were diagnosed with congenital cholesteatoma. Retrospective chart review was done. Among them, 65 cases were anteriorly located congenital cholesteatoma. A total of 53 patients were exclusively located in the anterosuperior quadrant. Other cases were extended to posteriorly (n = 4) or inferiorly (n = 8). Age distribution, types (closed or open), volumes (measured by tetrahedron beam computed tomography), ossicular involvement, and possible origin of cholesteatoma were assessed.
Mean age was 3.07 years (1-6). Patients older than 6 years were not encountered. Closed type was 61.5% (n = 40) and open type was 38.5% (n = 25). Volume of cholesteatoma was 59.38 ± 6.53 mm3 (closed type: 33.02, open type: 98.44). The incidence of open type and volume increased as age increased. Hearing loss was found in 5 cases. Ossicular involvement was found in 4 cases. During surgery, in many cases, the attachment of cholesteatoma to anterior side of cochleariform process was found by endoscopic examination.
Anteriorly located congenital cholesteatoma seems to originate from the anterior side of the cochleariform process. Its size grows with age and tends to rupture into open type. In addition, it might be washed out through E-tube as patients get older.
(1) Summarize hearing status in the nonimplant ear. (2) Report audiometric and subjective outcomes.
Multi-institutional retrospective chart review. We report outcomes of cochlear implantation in 12 patients with single-sided deafness. Hearing status in the nonimplant ear included: 6 patients with American Academy of Otolaryngology—Head and Neck Surgery Class A, 4 with Class B, and 2 with Class C (1 with WRS 90%). Five of 12 (42%) patients had normal hearing in the nonimplanted ear. There were 6 male and 6 female patients. Average age was 51.5 years (range, 9-75 years). Average preoperative word recognition score in the nonimplanted ear was 82% (range, 52%-100%). Average preoperative pure tone average was 30.4 dB (range, 2-60 dB).
Average post-implantation follow-up was 8 months (range, 1-36 months). Etiologies of deafness included 5 idiopathic sudden-sensorineural, 3 Ménière’s Disease, 2 idiopathic progressive, 1 labyrinthitis, and 1 iatrogenic. Audiometric results for the implant-only condition demonstrated mean consonant-nucleus-consonant score of 67% (range, 10%-88%) and mean AzBio score of 83% (range, 73%-97%). Objective testing in noise also showed substantial improvement compared to the preoperative condition. All are daily users.
Although cochlear implantation for asymmetric hearing loss and single-sided deafness is not Food and Drug Administration approved in the United States, our patients report a high level of satisfaction. Early audiometric data indicate that these patients score similarly to standard implant users in the CI only condition. In addition, they show substantial improvement in noise since preoperative testing. More data are needed to determine future candidacy for this intervention.
Otitis media comes with the need for cochlear implantation. These conditions contributing complications generated our interest in describing surgical difficulties and complications of cochlear implantation in children with otitis media, as well as estimating the period of time needed to implant those children.
Retrospective study of the data collected from records of patients receiving cochlear implantation. A total of 200 cochlear implant surgeries were performed in King Abdul-Aziz University Hospital from January 2012 to December 2012. Thirty-two patients had otitis media disease. For all patients’ complications, operative time, and duration from presentation to implantation were documented. Exclusion criteria were age 18 years or more, revision surgeries, patients that had auditory brain stem implant at the same time, and patients with incomplete data.
The complications were wound infection in one case and one case that developed hematoma. Both were treated conservatively and the last one was incomplete insertion. However, all belonged to the nonotitis media group. The operative time was longer in the otitis media group with a difference of 35 minutes (
Pediatric patients with otitis media can be implanted safely and effectively.
Compare the efficacy of 3 steroid regimes in the management of idiopathic sudden sensorineural hearing loss (ISSNHL) in an adult population in Trinidad, West Indies, where management of this phenomenon has not previously been described.
Retrospective review from 2005 to 2013 of 71 adults presenting with unilateral ISSNHL and treated within 72 hours of onset at a private general otolaryngology practice in Trinidad. Patients fell into 3 treatment groups: Group 1, oral prednisolone as the primary modality (n = 25); Group 2, oral prednisolone followed by salvage intratympanic methylprednisolone (n = 28); Group 3, intratympanic methylprednisolone as the primary modality (n = 18). Oral prednisolone was given as 60mg/d for 2 weeks and intratympanic methylprednisolone was given as 1 mL of a 40 mg/mL solution once weekly for 3 weeks.
Audiometric measurements were taken pre- and poststeroid therapy. Group 1: 50% (n = 13) of patients experienced an improvement in hearing (average 8 dB). Group 2: 22% (n = 6) of patients experienced an improvement in hearing (average 10 dB). Group 3: 88% (n = 16) of patients experienced an improvement in hearing (average 15 dB).
The use of intratympanic methylprednisolone as a primary modality in ISSNHL is likely to be more beneficial than oral prednisolone or as salvage therapy following prednisolone. Early intervention is associated with more favorable outcomes.
Compare acufenometry findings of patients with chronic unilateral disturbing tinnitus due to noise-induced hearing loss (NIHL) or presbycusis, and determine if there is an association with the degree of annoyance.
In this cross-sectional study, 38 patients with presbycusis and 17 with NIHL were evaluated between September 2003 and January 2014. The tinnitus pitch and loudness were evaluated using acufenometry. Tinnitus handicap inventory (THI) and the visual analog scale (VAS) were used to assess the impact of tinnitus on the patient’s life. Statistical analysis was performed using SPSS and Student
The mean age of the patients with presbycusis and NIHL was 67.74 ± 8.73 years and 62.29 ± 9.57 years, respectively (
Despite the differences observed in the cause of tinnitus and the mean ages of the patients, no significant difference was observed in the behavior of tinnitus in the groups with presbycusis and NIHL. Furthermore, tinnitus had a similar impact on the lives of patients from both groups.
Compare graft uptake rate and postoperative hearing results of myringoplasty using cartilage palisades and temporalis fascia in large perforations.
Prospective, longitudinal, randomized controlled trial from December 2010 to December 2012. at the Ganesh Man Singh Memorial Academy of ENT-Head and Neck Studies, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal. Patients were above 13 years of age with chronic otitis media-mucosal (tubotympanic) with >50% perforation of tympanic membrane. Sixty-one cases included for myringoplasty were randomly divided into 2 groups, cartilage palisades and temporalis fascia, by lottery. There were 30 cases in cartilage palisades group and 31 cases in temporalis fascia group. Patients underwent myringoplasty using either cartilage palisades or temporalis fascia. Graft uptake rate and postoperative hearing were evaluated after 12 weeks. Fisher exact test and
Graft uptake rate in the cartilage palisades group was 86.66% and 90.32% in the temporalis fascia group, with no significant difference (
The graft uptake rate and hearing results of myringoplasty with cartilage palisades are comparable to those of temporalis fascia in large perforations.
Approximately 20% of patients with congenital sensorineural hearing loss are found to have a radiologically proven inner ear anomaly. Of the inner ear abnormalities, duplication of the internal auditory canal is rare. We sought to describe clinical characteristics and treatment results of patients found to have duplicated internal auditory canal on imaging.
This case series identified patients from over a 2 year period obtained in a random manner from teaching files and daily case material. Imaging findings, clinical characteristics, audiology testing and treatment were reviewed.
A total of 7 patients were identified with a total of 12 ears (2 patients had unilateral presentation). Three patients in this series had a history of branchio-oto-renal syndrome. All patients had high-resolution computerized tomography (CT) performed. Two patients had magnetic resonance imaging (MRI) performed. All patients had audiogram evaluation. Six patients had sensorineural hearing loss, and one patient had conductive hearing loss. As hearing loss became more severe as documented by decibels of hearing loss on audiogram, increasing number of middle and inner ear anomalies were found on imaging.
This series is one of the largest series to evaluate duplicated internal auditory canal in conjunction with cochlear anomalies. MRI is a useful adjunct to evaluate presence of the cochlear nerve and should be considered in patients undergoing cochlear implantation with findings of duplicated internal auditory canal on CT scan. More severe hearing loss may be indicative of potential for more anomalies found on imaging.
Most acute low-tone sensorineural hearing loss without vertigo (ALHL) improves over time; however, some cases develop into typical Ménière’s disease (MD), suggesting an association between ALHL and MD. This study aimed to investigate associations between ALHL and MD from the perspective of development of the vestibular aqueduct.
Prospective case-control study at a tertiary referral center. In 51 patients with unilateral ALHL (15 males, 36 females; mean age, 52.3 years), 35 patients with unilateral MD (14 males, 21 females; mean age, 43.1 years) and 11 healthy controls (11 males; mean age, 33.3 years), length of the external aperture of the vestibular aqueduct (EAVA) was measured on 3-dimensional computed tomography. Results were then compared among ALHL patients, MD patients, and controls.
On the affected side, mean length of the EAVA was 5.8 ± 2.7 mm in ALHL patients, 4.3 ± 2.0 mm in MD patients, and 6.5 ± 1.5 mm in controls. The EAVA was significantly shorter in MD than in ALHL or controls. Among ALHL patients, length of the EAVA was significantly shorter in patients with recurrence (4.5 ± 1.9 mm) than in those without recurrence (6.4 ± 2.5 mm).
Hypoplasia of the endolymphatic sac may represent a predisposing factor for recurrence of ALHL and/or MD, as development of the endolymphatic sac is known to correlate with length of the EAVA.
(1) Review standard tympanoplasty approaches. (2) Describe a novel approach that minimizes soft tissue dissection and provides good access.
The charts of consecutive adult patients who underwent a conchal approach tympanoplasty between January 2010 and December 2012 at an urban teaching hospital under the care of a single surgeon were reviewed. The patient’s age in decades at the time of surgery, sex, and proportion of intact tympanic membranes noted at follow-up were recorded. Postoperative analgesic use and patient recorded satisfaction with the cosmetic appearance of the ear using a Likert type scale from 1 least to 5 most satisfied was collected for consecutive patients undergoing the procedure in 2013. The mean patient satisfaction score was calculated.
In the 3-year period from 2010-2012, the charts of 75 adults were reviewed. There were 45 females and 30 males with ages ranging from third to eighth decades. Complete tympanic membrane closure was achieved in 74 (98.7%). Twenty-one adults treated in 2013 recorded a mean satisfaction score with the appearance of the postoperative ear scar of 4.8 out of 5. Postoperative analgesic consumption consisted of acetaminophen or diclofenac sodium on the day of surgery. No patients used analgesics beyond postoperative day 2.
The conchal approach tympanoplasty is associated with a high graft take rate, low morbidity and high patient satisfaction with scar cosmesis.
Describe the sociodemographic of defaulters in the Universal Newborn Hearing Screening Program at UKMMC and to identify the associated factors.
A cross-sectional study was conducted at UKMMC from December 2011 until May 2013. Defaulter was defined as a patient who failed to attend the first stage hearing screening at UKMMC and also defaulted follow-up at the Audiology Unit between January 2010 and May 2011. The information was obtained through telephone inquiries to parents using the set of questionnaires. The factors studied were awareness of hearing loss, distance to the hospital, appointment date, and financial and transportation difficulties.
A total of 280 respondents were interviewed. The majority of the respondents were Malays (71.79%) in the middle income category. Nonawareness of the child’s hearing loss was the main associated factor (n = 205, 73.21%). The other associated factors were: appointment date was not given (n = 173, 61.8%), distance to the hospital (n = 126, 45%), appointment date given is too far away (n = 57, 20.4%), financial difficulties (n = 59, 21.1%), followed by respondents who do not have their own transport (n = 46, 16.4%).
Nonawareness of the child’s hearing loss by his or her parents was the major factor to the high default rate. Therefore, education and empowerment programs should be introduced and implemented at UKMMC in order to improve awareness among parents.
Illustrate strong and weak statistical concepts used in otolaryngologic papers submitted for publication regardless of acceptance.
For 1 calendar year, the type and number of statistical concerns were recorded for 56 otologic papers submitted for publication to 1 of 5 journals.
Ninety-nine concerns were found in 32 of the 56 papers. Reviewers identified several concerns in many papers. For some papers, data reanalysis was possible with different statistical tests, but in none was the conclusion altered. A summary of the findings with some overlap of the categories follows. Conclusions not supported by data – 13. Confusion of correlation with causation – 13. “Fishing trip” – 12. Overgeneralization – 9. Multiple
Application of statistics in otology papers was surprisingly good. The most common flaws in statistical interpretation in submitted papers were (1) that the conclusion reported was not supported by the data or (2) confusion between association and causation. Even if statistics were applied inappropriately, thoughtful reviewers were generally able to detect errors in statistical logic even if they did not feel that they were qualified as statisticians.
Over 200,000 individuals worldwide have received a cochlear implant (CI). Social media websites may provide a paramedical community for CI users, although their utilization patterns have not been thoroughly investigated. Herein, we aim to (1) analyze how CI users exchange information online and (2) quantify and characterize participation in social media.
Social media sources included Facebook, Twitter, YouTube, blogs, and online forums. Each source was assigned 1 of 6 functional categories based on its description. Using standard search engines, such as Google, we used the search terms cochlear implant, auditory implant, forum, and blog to identify relevant blogs and online forums. Website participation was quantified.
Over 350 sources were identified, including 122 YouTube videos, 111 blogs and forums, 57 Facebook groups, 32 Facebook pages, and 50 Twitter accounts. The most active online communities were Facebook groups, which totaled 17,971 members. CI users participated in Facebook groups primarily for general information/support (68%). Online forums were the next most active online communities by membership. The largest forum had ~9500 topics with ~127,000 posts. CI users primarily shared personal stories through blogs (92%), Twitter (71%), and YouTube (62%).
This is the first known comprehensive review of utilization patterns of social media in the CI community. CI users engage in a wide range of online platforms predominately to provide general information and share personal stories. Analyses of how CI users participate in social media may enable clinicians to identify key concerns of this specialized patient population.
Differentiate mesenchymal stem cells to otic progenitor-like cells.
We isolated and cultured the stromal vascular fraction (SVF) of 3 samples of human adipose tissue. We differentiated human adipose stem cells (hASCs) to otic lineage, using a differentiation medium containing DMEM HG, F12, N2, B27 and different growth factors like FGF3, FGF10, EGF, and IGF-1. The differentiated cells were fixed and RNA extracted at day 10 and 38 to analyze the expression of otic progenitor, neuronal or inner ear hair cell markers.
After 10 days of differentiation we detected otic placode markers expression: Pax2 (90.9 ± 0.16%), Pax8 (44.2 ± 0.03%), and BMP7 (86.4 ± 0.24%). Brn3.c (24.2 ± 0.05%), MyoVIIa (10.8 ± 0.05%), and BIII tubulin (28.8 ± 0.37%) were also detected, consistent with the presence of progenitors of sensorineural and inner ear hair cells. At day 38, an increase of inner ear hair cell markers (33.2 ± 0.04% MyoVIIa, 33.9 ± 0.3% Brn3.c and 14.3% Math1), a decreased of otic progenitor markers (46.2% Pax2 and 15.9% Pax8) and absence of neural markers were seen. The same pattern was seen at mRNA level.
Even though these results are preliminary and a protocol improvement is necessary, this work demonstrates the ability of hASCs to differentiate into otic lineage, opening a door to a future therapeutic option for sensorineural hearing loss.
Loss of mammalian auditory hair cells is usually permanent, and there is currently no method to recover hearing after hair cell damage. Atoh1, a basic helix-loop-helix transcription factor, plays a critical role in formation of hair cells. Experiments overexpressing Atoh1 in the inner ear via gene transfer have shown new hair cell formation and improved hearing in tested animals. However, we do not currently know how cells regulate Atoh1. We found that Sox2, a pluripotency marker for stem cells and also present in inner ear stem cells, is involved in the regulation of Atoh1. In this study, we try to understand the role of Sox2 in the regulation of Atoh1 for hair cell formation.
A 293T cell line that stably expresses Atoh1 was developed for Atoh1 expression assays. Atoh1 level was measured by real time qPCR and western blot. Mass spectrometry was used to identify Atoh1 protein partners. Plasmids transfection was used for gain-of-function studies, while small interfering RNA was used for loss-of-function studies.
We found that Sox2 upregulates Atoh1 at the transcriptional level but also enhances Atoh1 degradation post-translationally. We found that Sox2 is involved in the major post-translational regulation, the ubiquitin-proteasomal pathway, which is the control mechanism through which Sox2 regulates specification of hair cells.
Sox2 has dual role on Atoh1 regulation: upregulation of Atoh1 transcription by binding to Atoh1 3′enhancer, and post-translational Atoh1 degradation through activating ubiquitin-proteasome pathway.
Elucidate whether endolymphatic sac decompression surgery (ESDS) has the potential to prevent unilateral Ménière’s disease (MD) from becoming bilateral.
Prospective case-control study. Between 1996 and 2008, we performed a glycerol test (G-test) and electrocochleography (ECoG) on 237 patients with intractable MD at a tertiary referral center. We performed ESDS on 179 patients (144 without endolymphatic hydrops and 35 with silent endolymphatic hydrops in the contralateral ear). The other 58 patients (40 without endolymphatic hydrops and 18 with silent endolymphatic hydrops in the contralateral ear) were given available medical treatments. All underwent regular follow-up for at least 5 years.
Altogether, 22.4% (53/237) of patients with clinically diagnosed unilateral intractable MD had silent endolymphatic hydrops in the contralateral ear using G-test and ECoG. In the nonsurgical group, 6 of 40 patients with unilateral MD without endolymphatic hydops in the contralateral ear developed bilateral disease, whereas in the surgical group, 12 of 144 patients did so (
The present findings suggest that ESDS may decrease the incidence of developing MD in silent endolymphatic hydronic contra lateral ears diagnosed with G-test and ECoG within the first 5 postoperative years.
Analyze the difference in acufenometry between patients with presbycusis and Ménière’s disease and correlate the findings with the annoyance caused by tinnitus.
This cross-sectional study included 59 patients with unilateral tinnitus treated at a tertiary hospital. Out of these patients, 38 had presbycusis and 21 had Ménière’s disease. Acufenometry was performed to determine the pitch and loudness of tinnitus in the 2 groups. The tinnitus handicap inventory (THI) and visual analogue scale (VAS) was used to evaluate the annoyance caused due to tinnitus. Statistical analysis was performed using SPSS and the Student
The mean age of the patients with Ménière’s disease and presbycusis was 56.05 ± 8.73 years and 67.74 ± 8.73 years, respectively (
Although tinnitus was louder in patients with Ménière’s disease than in those with presbycusis, the tinnitus pitch and its impact on patient quality of life was similar in both groups.
Sensorineural hearing loss associated with acute otitis media (acute infective sensorineural hearing loss [AISNHL]) is a well-recognized but rare phenomenon with no accepted treatment pathway. Our objectives were to (1) evaluate the effects of intratympanic steroid (ITS) administration on AISNHL and (2) analyze factors which may be associated with a favorable outcome following ITS.
A retrospective case note review of 7 consecutive patients (5 men, 2 women) seen between November 2006 and October 2013 and diagnosed with AISNHL was performed. Patients were prescribed 7 days of oral antibiotics and prednisolone and offered ITS thereafter if there was no improvement. Up to 3 intratympanic injections of methylprednisolone (40 mg/mL) were administered.
Patients were considered to have a significant improvement in their hearing if average change in threshold was equal to or greater than 10 dB following ITS. This was the case in 57% (4/7) of patients. The mean improvement in threshold was 24 dB (range 10-52 dB) in these responders. Three-fourths of responders had a mild high frequency hearing loss. Responders had a smaller sensorineural loss at presentation (responders mean 39 dB pre-ITS,15 dB post-ITS; nonresponders mean 65 dB pre-ITS, 83 dB post-ITS), presented earlier (4 days, range 3-6 days versus 12 days, range 2-21 days) and received their first ITS earlier (24 days, range 13-37 days versus 35 days, range 24-42 days) than nonresponders.
ITS may provide a valuable contribution to the treatment of SNHL in acute otitis media. A larger study looking at timing of intratympanic administration after antibiotics and/or oral steroid treatment would be beneficial.
Postoperative regeneration of the middle ear mucosa and pneumatization of the middle ear cavity are of great importance after middle ear surgery. This study developed a new method to transplant autologous nasal mucosal epithelial cell-sheets into the damaged middle ear cavity. The aim of this study was to evaluate postoperative healing after the transplantation of the cell sheets in rabbits.
Rabbit nasal mucosal epithelial cell-sheets were fabricated from a temperature-responsive culture dish and transplanted into the damaged middle ear of the rabbit, which was surgically created. The healing of middle ears was evaluated with histological methods and computed tomography findings at 8 weeks after transplantation. Functional evaluation was performed by measuring the maximum middle ear total pressure reflecting a trans-mucosal gas exchange function. Two control groups were used: the normal control group and the mucosa-eliminated control group.
Transplantation of nasal mucosal epithelial cell-sheets suppressed the bone hyperplasia and the narrowing of pneumatic space in the middle ear cavity more clearly than the mucosa-eliminated control group. The mucosal gas exchange function was also found to be good in the cell sheet-transplanted group. These results suggest that posttransplanted middle ear cavity is not only morphologically but also functionally similar to the normal middle ear cavity.
Nasal mucosal epithelial cell-sheet is confirmed to be useful as an effective graft material after middle ear surgery, and will hopefully become a novel therapy in the future.
The spatiotemporal distribution of drugs in the inner ear has not fully been characterized because of the area’s small size and complicated compartments. In the present study, we investigate the pharmacokinetics of a small molecule conjugated with different amounts of carrier in the cochlea by using transgenic technology and the IVIS Imaging System.
Luciferin, a 280 MW substrate of luciferase, was conjugated with different MW of hyaluronic acid and was subcutaneously administered to the transgenic mouse, GFAP-luc, which expresses luciferase specifically in the cochlear spiral ganglion cells. Bioluminescence produced by a chemical reaction of luciferin-luciferase was monitored using the Xenogen-IVIS 100.
The peak photon count decreased dose-dependently on the MW of hyaluronic acid, whereas the duration was prolonged.
Our imaging system successfully detected differences in the pharmacokinetics of luciferin in the inner ear. The sustained-release effect of hyaluronic acid was observed and differed by its MW. The result suggests the clinical significance of hyaluronic acid for controlling drug delivery to the cochlea.
Evaluate the efficiency of exploration of molecular genetic etiology for cochlear implantees (CI).
Ninety-four patients of 273 CIs who consented to molecular genetic testing (MGT) were included. Patients with either a characteristic radiologic or audiologic marker were subject to Sanger sequencing of corresponding candidate genes. The GJB2 gene was sequenced in patients with no phenotypic marker. Targeted resequencing of known 200 deafness genes (TRS-200) was applied to GJB2-negative cases with no phenotypic marker. The recurrence risk of hearing loss (HL) between undiagnosed probands after TRS-200 and diagnosed probands with autosomal recessive genotype was evaluated.
Thirty of 42 probands (71.4%) who underwent the direct Sanger sequencing of candidate genes were diagnosed. The most rewarding phenotypic markers were enlarged vestibular aqueduct (with/without incomplete partition [IP] type II) and IP type III, followed by long QT syndrome, lateral semicircular canal dysplasia as a part of the constellation of anomalies suggesting a CHARGE syndrome, and ski-slope type high frequency HL. Focusing upon these 5 markers, the detection rate went up to 83.3% (30/36). Ten of 52 probands carried mutant allele of GJB2. The detection rate by TRS-200 was 26.0% (12/46). The recurrent risk of HL was calculated to 0.03 (95% confidence interval [CI] 0-0.13) in undiagnosed group and 0.18 (95% CI 0.09-0.34) in diagnosed probands.
Molecular genetic diagnosis was made in 55.3% (52/94) of CIs through our hierarchical MGT. The sequencing of high-yield candidate genes associated with phenotypic markers will be useful for evaluating deaf patients cost-effectively before applying next generation sequencing. A Mendelian genetic etiology does not seem to contribute to undiagnosed probands after TRS-200.
Laser irradiation applied inside the inner ear has been investigated to observe the therapeutic effectiveness in cochlear injury and vestibular dysfunction. The positive influence of light irradiation with low level laser therapy on the treatment of vascular disorders, ischemic arteriolar disease, activation of microcirculation, and tissue regeneration is well known and has been published by several authors from medical research groups. The aim of this study was to determine the effects and benefits for patients with Ménière’s disease and other vestibulopathies who received an irradiation dose into the inner ear by using a protocol of irradiation.
A laser device with double wavelength and independent light beams was used to irradiate through the ear canal with power irradiance of 90 to 300 mw/cm2 at different dose rate according to patient symptoms. A prospective study of a group of sixty five (65) patients who were suffering peripheral vestibular disorder were treated from January 2010 to July 2011 in a random selection with no exclusions for other pathologies. Method of irradiation was direct beam over “meatus acusticus” at 1.5 cm distance of ear drum membrane.
Fifty patients of the 65 were considered final group control. According to American Academy of Otolaryngology—Head and Neck Surgery guideline criteria, 64% were classified as Category A on their vertigo management and 36% were Category A+B. After the treatment period, both categories confirmed that crises were shorter, less severe and with lower intensity.
Laser irradiation has no risk for patients and can be considered both effective and an alternative therapy.
Compare MED-EL fine structure processing (FSP) and high-definition continuous interleaved sampling (HDCIS) in discrimination of musical instrument harmonic changes.
Twelve MED-EL users were programmed with novel FSP and HDCIS maps. With each map they underwent discrimination testing of paired sound stimuli. The stimuli were native and harmonically-manipulated sound clips of a single note played by an instrument. The instruments tested were the trumpet, alto saxophone, and tuba. The harmonic manipulations consisted of removal of either the first or second harmonic. Discrimination was quantified by calculating d′; higher d′ values indicated better performance.
There were no significant differences in discrimination performance between FSP and HDCIS across conditions. However, for both strategies, significant differences in discrimination were observed between discrimination of the first and the second harmonic manipulation conditions for the trumpet and the tuba. For trumpet, significantly better performance was observed with removal of the second harmonic (d′ = 1.57) compared with removal of the first harmonic (d′ = 0.58;
Results from this novel-map study did not show a difference in harmonic cue discrimination between FSP and HDCIS. Evidence was found regarding important harmonic information for individual instruments tested. Perception of harmonic cues could be affected by channel discrimination. These results can be used to improve cochlear implant signal processing strategy.
Peripheral facial palsy (PFP) is a disorder of common neural causes that are still unknown. Other possible causes include vascular disorders, inflammatory and immunological factors, and possibly viral infections. According to the literature there is an association between the incidence of PFP and diabetes mellitus (DM), a disease which is known to cause neuropathies. The objective of this study is to evaluate the outcome of patients with concomitant DM and PFP, as well as to compare the evolution of these patients compared to patients without DM and PFP through clinical, laboratory, and electrophysiological tests.
An observational case-control study. Outpatient follow-up between 2011-2012 of 50 patients according to the presence or absence of PFP and DM that were divided into 4 groups and matched. All patients underwent the following tests: tearing (Schirmer’s test), tonal and speech audiometry, tympanometry with reflex of the stapedius muscle, Test Hilger, and glucose analysis.
The rate of complete recovery considered grade I or II of the House-Brackman classification at the end of 6 months of follow-up showed that 58.4% of diabetic patients presented a good evolution in contrast to 80% of nondiabetics.
In our findings we concluded that diabetic patients had a slower recovery time and poor degree of facial paralysis when compared to nondiabetics.
We aimed to evaluate hearing results and complications of anterior atticoantrostomy in pediatric patients who had cholesteatoma.
This is a clinical retrospective study. Fifty children who underwent anterior atticoantrostomy for cholesteatoma were included. Patients’ preoperative and postoperative pure tone audiometry results were compared. In addition, postoperative complications including formation of retraction pockets, perforation, recurrence of cholesteatoma, and absorption of cartilage were analyzed.
The mean age of the patients was 12.7 years, with 27 female and 23 male patients. Patients’ preoperative and postoperative air-bone gaps were narrowed significantly. Number of retraction pockets, recurrence of cholesteatoma, and perforations seen were 3, 7, and 4, respectively.
Anterior atticoantrostomy is a safe method with low complication rate and can be applied in pediatric cholesteatoma cases with good hearing results.
(1) Investigate the difference in epitympanic bony volume and size of tympanic isthmus (TI) between human temporal bones (HTBs) with and without chronic otitis media (COM). (2) Investigate the relationship between TI size and epitympanic bony volume in HTBs with and without COM.
Eleven HTBs from children with COM (COM group) and 11 HTBs without COM (control group) were examined. Three-dimensional models were generated from HTB histopathologic slides with reconstruction software (Amira), and epitympanic bony volumes were measured. Within the boundaries of TI, only the aerated space, excluding exudates and soft tissues, were measured as aerated TI, and all space surrounded by the boundaries including exudates and soft tissues were measured as the bony TI. We chose the minimum aerated/bony TI area from all slides and compared them between the 2 groups. We also investigated the correlation between bony epitympanic volume and minimum aerated/ bony TI area in each group.
There were no significant differences in epitympanic bony volume or bony TI area between the groups. Aerated TI area in the COM group was significantly smaller than in control group (
Our study suggests that congenital or developmental stenosis of the TI is not associated with epitympanic pathology, but blockage of TI with soft tissue pathology is.
(1) Review the occurrence of electrode migration following cochlear implantation. (2) Compare the rate of migration in those patients who underwent concurrent radical mastoidectomy.
A retrospective case series of all patients who underwent cochlear implantation at our institution, with a single surgeon, between 2001 and 2013. The specific outcome studied was implant migration. A total of 224 patients underwent cochlear implantation with a total of 294 implants performed. Four patients (1.3%) underwent radical mastoidectomy with Rambo type obliteration of the external auditory canal.
This approach was used in 2 young children with congenital malformations to provide adequate exposure for cochleostomy, and both of these patients experienced electrode migration. In 2 older patients this approach was used due to chronic infections, and neither of these patients has electrode migration. Of the 224 patients in the series who underwent cochlear implantation, these 2 children are the only patients who have experienced implant migration.
Electrode migration is a rare complication following cochlear implantation. In our experience, there seems to be a higher incidence of electrode migration in patients who have undergone cochlear implantation in association with radical mastoidectomy with external auditory canal obliteration. Alternative techniques to avoid the need for the canal-wall-down mastoidectomy with Rambo closure have been used with success and are described in detail.
Describe a minimally invasive transcanal endoscopic approach, starting from the external auditory canal and reaching the internal auditory canal, used to treat inner ear pathology.
Three patients, affected respectively by cochlear schwannoma, acoustic neuroma, and temporal bone cholesteatoma, were treated by an exclusive endoscopic approach without external incisions. Surgical steps and useful landmarks were reviewed and described.
The operation provided a direct transcochlear intradural approach from lateral to medial and from external to internal auditory canal, without any external incision. The pathology was totally removed in all patients. Results regarding facial nerve were very satisfying. Hospital stay was markedly reduced compared to traditional approaches.
The transcanal exclusive endoscopic approach proved successful for pathology removal involving the fundus, internal auditory canal, and cochlea. Potential future application of this kind of approach in lateral skull base surgery will depend on the development of technology and surgical and anatomical refinements.
(1) Three-dimensionally (3D) visualize the cochlear vessels and blood-labyrinth barrier. (2) Analyze the expression of angiogenic molecules in cochlear vessels.
Postnatal day 5 and 8-week old mice were used. After obtaining the cochlea, bony shell was removed. Whole mount immunostaining was done with endothelial cell marker PECAM-1 and VE-cadherin. NG2 and demins were used for pericyte marker. aSMA was used as vascular smooth muscle cell and S100 was used as fibrocyte marker. 3D reconstruction was done to visualize the blood-labyrinth barrier components. VEGFR2, VEGFR3, Sox17, angiopoietin-2, Dll4 were used for angiogenic markers. Claudin-5 was used to visualize the tight junction.
We could visualize the cochlear vasculature in overall, from precapillar arteriole, stria vascularis, and postcapillary venule. The relationship between components of blood-labyrinth barrier also could be visualized from basal turn to apical turn of the cochlea. Cochlear vessels well expressed VEGFR3, VEGFR2, Sox17 in the endothelial cell showing that cochlea is in active state, not static. Claudin-5 was robustly expressed suggesting its important role in blood-labyrinth barrier. aSMA was well expressed demonstrating its need for vessel contraction.
A vessel is not merely a conduit for blood flow. It is newly made and is also regressed. It permits or limits many molecules on crossing over to the tissue. The cochlear vessel is an active vessel. We suggest that visualizing the cochlear vessel and checking the expression of angiogenic molecules could help understand the pathophysiology in hearing loss models.
(1) Evaluate the outcome of fat myringoplasty in relation to the perforation size. (2) Compare the outcome in relation to 2 fat sources (ear lobule and abdominal wall).
This study was conducted between May 2012 and April 2013 in the ENT department, University of Alexandria, Egypt. It was carried out on 30 patients with tympanic membrane perforations <30% of its surface (20 patients with perforations equal or less than 2 mm and 10 patients with perforations exceeding 2 mm in diameter), and with a maximum air bone gap of 20 dB. There were 2 randomized groups. Group A: 15 patients who had myringoplasty with ear lobule fat. Group B: 15 patients operated on using abdominal wall fat. Patients were followed for 6 months postoperatively.
Among the 20 patients with a perforation size ≤2 mm, 18 patients (90%) succeeded and 2 (10%) failed. Among the 10 patients with a perforation exceeding 2 mm, 5 patients (50%) succeeded and 5 (50%) failed. There was a significant statistical difference between perforation size and success rate. In group A, 12 patients (80%) had successful operations and 3 patients (20%) failed. In group B, 11 patients (73.3%) were successful and 4 patients (26.7%) failed. There were no significant differences between the 2 groups with regard to the success rate and hence its relation to the fat source (
Fat myringoplasty can be performed safely in cases with small perforations, especially up to 2 mm in diameter and small air bone gap. Ear lobule constitutes a convenient source of fat.
Presbycusis is hearing impairment resulting from aging. Hearing-impaired elderly are more likely to experience emotional distress, social engagement restrictions, and depression. Hearing loss also affects posture and balance and predisposes patients to falls. In comparison to universal screening of newborns, efforts for early diagnosis and prevention of hearing loss in the elderly are still insufficient. A prevalence study of disabling hearing loss in a developing country detected 30% of affected elderly. The aim of the study was to perform a screening of disabling hearing loss (DHL) in the elderly in a city of a population of 500,000 and to detect hearing loss in the elderly without diagnosis and offer them audiologic rehabilitation.
A cross-sectional population screening of 70,000 elderly individuals of which approximately 21,000 are probably hearing impaired and about 12,000 are in need of some kind of rehabilitation. The work consists of promoting a city campaign to submit all citizens over 60 years to an ear, nose, and throat (ENT) consultation, including audiometric tests and survey applications.
In the first year, 4080 examinations were performed. Of these, 960 had indication for hearing aids. Statistical analysis was performed using descriptive and exploratory techniques of data.
The preliminary results indicated a high prevalence of hearing impaired aged adults in whom medical intervention (rehabilitation) can potentially prevent further complications and co morbid conditions. In future perhaps we will have evidence to recommend universal screening in everyone above 65 years.
Investigate the efficacy of intratympanic methylprednisolone perfusion (IMP) for severe and profound sudden sensorineural hearing loss (SSNHL).
Hearing recovery was analyzed retrospectively in SSNHL patients, who received IMP after not fully responding to conventional treatments and were hospitalized in our department between January 2008 and December 2012.
Eighty-seven patients with SSNHL were divided into 4 types according to primary hearing curve: total deafness (77.01%), mild to moderate hearing loss in all frequencies (18.39%), hearing loss in low-tone frequencies (2.30%), and hearing loss in high-tone frequencies (2.30%). The effective rate was 66.7% and average pure tone average (PTA) improvements were 18.53 ± 13.54 dB in the patients of interval from onset to IMP within 15 days, 21.2% and 5.92 ± 15.18 dB in the patients of interval between 16 and 30 days, 4.8% and 3.69 ± 7.00 dB in the patients of interval more than 30 days, respectively. The effective rate had significant differences among the 3 different interval groups (χ2 = 25.91,
Receiving IMP earlier may help to improve hearing recovery for the patients with SSNHL not fully responding to conventional treatments. The hearing improvements in the lower frequencies may be better than those in the higher frequencies after IMP.
Optogenetics affords the potential for improved spatial resolution compared with electric stimulation in future auditory neuroprostheses. No histologic studies have yet examined the virally-mediated gene transfer of Chronos, a new opsin, to the murine cochlear nucleus (CN). Herein, we aim to (1) identify CN regions and neurons receptive to gene transfer of Chronos and (2) describe the morphology of putative cell types that express Chronos.
CBA/CaJ mice underwent CN-targeted injection of Chronos. The Chronos construct consisted of an adeno-associated viral vector (AA2/8), CAG promoter, and a fluorescent marker. Following a 4-week incubation period, mice were sacrificed and intravascularly fixed with paraformaldehyde, and brains were extracted, sucrose cryoprotected, and cryostatically sectioned. Sections of 35-µm thickness were co-labeled with neuron-specific markers microtubule associated protein-2 and anti-tubulin, beta III isoform and DAPI-fluoromounted. Sections of 60-µm thickness were DAPI-fluoromounted, and confocal microscopy revealed cellular morphologies.
Opsin-linked fluorescence demonstrates Chronos expression throughout the dorsal CN with contiguous extension routinely into the ventral CN and variably into the auditory nerve and inferior cerebellar peduncle. Chronos localizes to neuronal-specific and nonneuronal populations. Confocal microscopy suggests involvement of a wide array of CN cell types, including morphologies consistent with pyramidal cells and giant cells.
Our histologic analyses confirm widespread infection of multiple neuronal populations throughout the CN. This work sets the stage for correlation with ongoing neurophysiology experiments. Future work with CN-specific promoters to target neuronal subpopulations may further improve clinical potential for an optogenetics-based auditory neuroprosthesis.
There are several theories about pathophysiologic mechanisms involved in hyperacusis as an inner ear disease. Several authors discuss and focus hyperacusis around neurophysiological processes currently against the cochlear poor condition. This research describes effects of treatment by laser light irradiation on hyperacusis and recognizes that hyperacusis is a poor cochlear disorder instead of other auditory or neurophysiologic processes.
A prospective study of a group of 58 patients who were suffering hyperacusis from several inner ear disorders (Ménière’s, tinnitus, and other disorders) was made with laser irradiation therapy based upon a photobiostimulation energy protocol. Patients were treated twice a week for 6 weeks by irradiation of a dose of low-level laser light. A laser device with double wavelength and independent light beams were used to irradiate through the ear canal with light power irradiance of 90 to 300 mw/cm2.
Hyperacusis significantly improved in all patients. Ninety-nine percent of observations had a large improvement of auditory capacity and 78.9% of them reached normal discomfort levels (no hyperacusis). Dynamic range of each ear was measured before and after treatment.
Irradiation of the cochlea with a specific dose of light laser energy produces an obvious improvement in hyperacusis and other auditory disorders. This can be evaluated by comparing the audiometric dynamic range before and after the treatment period. The results confirm that hyperacusis as a disorder is more susceptible to a poor cochlear condition than other known neurophysiological processes.
Determine the efficacy of hyperbaric oxygen therapy (HBOT) in idiopathic sudden sensorineural hearing loss (ISSHL) after unsuccessful treatment with oral and intratympanic corticosteroids. The current treatment for ISSHL remains controversial. Systemic and intratympanic steroids are usually prescribed; unfortunately, only 61% of patients achieve full recovery. Recently, hyperbaric oxygen therapy has emerged as a new possible treatment.
Case series at a secondary care center. Patients were included from March 2013 to July 2013. Inclusion criteria: age >18 years, failure to systemic and intratympanic corticosteroids. Ten sessions of HBOT were conducted, 60 minutes each, at 2 atmospheres. All patients underwent audiometry before and after treatment. Pure tone average (PTA) was defined as the average of the frequencies of 500, 1000, 2000, and 4000 Hz.
We included 4 female patients, mean age 51 years. The mean time from onset of illness to HBOT was 108.75 days. Initial mean PTA was 55.31 dB, final PTA was 54.6875 dB (
The use of HBOT in patients who fail steroid therapy did not demonstrate a beneficial hearing effect in ISSHL patients. However, symptoms such as dizziness improved subjectively. More studies are needed to corroborate our results.
Identify and differentiate among the cranial nerves (CN) and vessels close to the foramen of Luschka (FL) and improve the understanding of the normal and abnormal microanatomy in children with cochlear nerve deficiency (CND) fitted with auditory brainstem implants (ABI).
From 2000 to 2013, 64 children ranging in age from 8 months to 16 years (2.92 ± 1.54) with CND and several degrees of cochlear abnormalities were video-recorded during retrosigmoid surgery for ABI fitting. Four independent experts retrospectively examined all the videos. CNs VI, VII, IX, X, XI and the vascular structures around the FL were identified either by surgical inspection and/or intraoperative neurophysiological monitoring.
Cranial nerves VI, VII, VIII were absent respectively in 3, 8 and 64 children; CN VII had an aberrant course in the CPA in 18 children; bifurcated in 4 and trifurcated in 3; CNs IX, X and XI were observed in all children; a double CN XI was observed in 2 children; and the nerve root bundles of the cranial and spinal segment of CN XI were identified in 48 and 52 children, respectively. Landmarks useful in identifying the FL included the nervus intermedius, CNs VII and IX, and the choroid plexus of the lateral recess.
The collection of surgical images allowed a successful display of the detailed normal and abnormal anatomy of the CNs and vessels around the area of the FL. These data have the potential to facilitate an uneventful approach to the FL and a correct insertion of the ABI array.
Recognize the differential expression of osteoprotegrin (OPG) in the otic capsule of adult male mice compared with other selected skeletal bones, both in nearby locations such as the temporal bone, and in distant bones, such as the tibia.
The experimental study was conducted in 2011 on 20 normal adult male albino mice with average weight 50 to 60 g. Animal housing at the physiology department (Alexandria Faculty of Medicine) followed the rules of research ethics for experimental animals approved by Faculty of Medicine, University of Alexandria, Egypt. The following bone specimens were harvested from normal adult male albino mice by microdissection: (1) temporal bone, (2) otic capsule bone surrounding the cochlea, and (3) tibia and stained immunohistochemically for anti-OPG monoclonal antibody. Positive staining was graded and analyzed using image software that measured the staining intensity as units of pixels/microscopic field examined at 400 magnification. Quantitative data were described using mean, standard deviation, median, minimum and maximum. Comparison between different sites were analyzed using F-test (analysis of variance) and post hoc test (least significant difference) for pairwise comparison.
OPG was detected as a brown DAB chromogen staining of tissue components expressing a positive OPG monoclonal antibody immune reactivity. Statistical analysis of the results revealed that high OPG level concentrations were found in otic capsule followed by temporal bone and finally the tibia.
The findings highlight the role of a OPG in inhibition of otic capsule remodeling.
This study aims to determine the negative effects of diving on hearing and to compare the hearing levels of the industrial divers to the recreational ones.
The study was conducted among industrial divers (ID) and recreational divers (RD) between June 2012 and November 2013. A total of 30 industrial divers and 30 recreational divers were recruited. The participants received a self-structured questionnaire, detailed otolaryngologic, otologic, and radiologic examinations. The continuous variables were compared using the Student
The mean age of the ID group was 28.3 ± 4.4 and RD was 32.7 ± 5.2. Hearing levels above 25 dB were considered as normal. No significant hearing loss was obtained in the ID group while the RD group had mild to moderate hearing loss (
Although IDs dive more frequently than RDs, their age, physical capacity, and diving depth plays a major saving role on their hearing levels. It is a well-known fact that RD are older and dive deeper. To best of our knowledge and from our results, older age and deeper depths are believed to worsen the hearing levels.
(1) Investigate factors that impact low frequency hearing preservation following cochlear implantation. (2) Evaluate the efficacy of a perioperative oral steroid taper in this setting.
Retrospective series from a single surgeon at a tertiary academic referral center. Patients were candidates for a hearing preservation protocol based on their preoperative pure tone thresholds. The tympanic space was bathed in steroids prior to opening the round window membrane in all cases, and all patients were implanted using electrodes designed for atraumatic insertion. One group of patients received a 2-week oral prednisone taper beginning 3 days prior to surgery. The primary outcome measure was the preservation of low frequency pure tone hearing on a 1-month postoperative audiogram.
Twenty-two hearing preservation candidates were implanted during an 18-month period (mean age 50 years; range 3-80) ending in December 2013. Thirteen patients (59.1%, mean age 45.6 years) received the oral prednisone taper while 9 (40.9%, mean age 56.3 years) did not. There was no significant age difference between the groups (
Oral steroids may play a role in low-frequency hearing preservation following cochlear implantation. Though the optimal protocol has yet to be identified, a 2-week oral prednisone taper given 3 days before surgery appears to positively impact the rate of and degree of preservation.
(1) Evaluate the influence of tinnitus upon the auditory spectral and temporal resolution. (2) Evaluate the effect of tinnitus on speech perception ability in noise.
To exclude the effect of decreased hearing threshold, unilateral idiopathic tinnitus patients with symmetric hearing threshold were enrolled. The subjects were 13 patients with symmetric hearing loss >20 dB HL and binaural difference <10 dB at 0.25, 0.5, 1, 2, 3, 4, and 8 kHz, or who have normal hearing threshold and binaural difference <10 dB at 0.25, 0.5, 1, 2, 3, 4, and 8 kHz, and threshold discrepancies <15 dB at 9, 11.2, 12.5, 14, 16, 18, and 20 kHz. A total of 13 volunteers with normal hearing were enrolled as a control group. Four different psychoacoustic measurements were performed: (1) spectral-ripple discrimination, (2) temporal modulation detection, (3) Schroeder-phase discrimination, and (4) word recognition in noise.
There were no significant differences in spectral-ripple threshold, temporal modulation detection threshold, and Schroeder-phase discrimination between affected sides and non-affected sides of unilateral tinnitus patients. For the word in noise test, affected sides showed worse signal-to-noise ratio compared to non-affected side.
We could not find any evidence that the tinnitus-affected ears show worse spectral and temporal processing compared with nontinnitus ears in unilateral tinnitus patients. The spectral ripple discrimination data suggests that the tinnitus-affected ear does not have more damage in its cochlea (especially the outer hair cell) causing the auditory filters to broaden compared with the nonaffected ear with the same hearing threshold.
The difficulty in choosing appropriate therapy for chronic tinnitus lies in its various forms of impact on the quality of life of patients and requires personalization. The aim of the study was to evaluate the efficacy of the use of sound generators with individual adjustments to relieve tinnitus in patients unresponsive to previous drug treatment.
This was a prospective study of 10 patients, 5 male and 5 female, ages ranging from 41 to 78 years with chronic tinnitus who were resistant to previous drug treatments. Bilateral sound generators Reach62 or Mind 9 models were used for at least 6 daily hours for 18 months. Audiometrics testing, pitch, loudness, minimum masking level (MML), Tinnitus Handicap Inventory (THI), Visual Analogue Scales (VAS), and Hospital Anxiety and Depression Scale (HADS) questionnaires were given. Sound generators were used before 1 month and, sequentially every 3 months up to 18 months. The sound generators were individually adjusted, according to criteria of personal complaints in each visit.
There was an important reduction in tinnitus in 9 patients using an protocol with a personalized approach, independent of its psychoacoustic characteristics, when THI and VAS were applied. Patients with more than one specific kind of tinnitus concomitantly showed more reduction in pure tone tinnitus. Only 1 patient was indicative of depression in HADS and did not respond to sound therapy.
We observed an importance in the individual adjustments in therapy, regardless the equipment used. There was an improvement in tinnitus disturbance and quality of life of these patients.
Review the literature regarding auditory brainstem implant (ABI) indications, surgical techniques, activation methods, and postsurgery follow-up in children.
A search was performed in LILACS, MEDLINE, SciELO, and PubMed databases from January to March 2013, and the key words used in the search were brainstem AND implant OR implantation AND children OR child. Studies that referred to results of the ABI fitting process in children were selected.
Seventy-two studies that met the criteria were read in full; 17 studies referred to the ABI fitting process in children and were selected for appraisal. The studies showed the cases of 49 children (younger than 18 years old) fitted with ABIs. Evaluation after surgery showed that 47 (95.9%) of the patients improved in their ability to recognize environmental sounds and speech perception. Patients with tumors or those with cochlear or cochlear nerve malformations had good outcomes as well. Two of the children achieved no sound perception upon ABI activation.
The US Food and Drug Administration (FDA) only approves the auditory brainstem implant for children older than 12 years old, but good outcomes in children younger than that age were achieved, improving environmental sound awareness and oral language development. The FDA only recently approved clinical trials for patients younger than 12 years old. We propose that the FDA auditory brainstem implant indications should be extended to patients with nontumoral diseases of the cochlea and cochlear nerve and younger than 12 years old.
Otolaryngology was one of the first specialties to use intraoperative nerve monitoring (IOM) to reduce the risk of facial and recurrent laryngeal nerve paralysis. Unfortunately, many external changes have occurred in the field that impact standards of care and correct coding. The objective is to identify these new external standards so AAO members can describe and apply new regulations to reduce adverse medicolegal and coding abuse risks.
Rigorous, newly published standards in neurophysiologic monitoring created by neurologic and electrodiagnostic associations are reviewed and compared with the more lax procedures commonly used by otolaryngologists with informal, on-the-job IOM training. Similarly, new third party payor changes in billing and coding are reviewed and compared to common IOM coding practices.
A comparison of routine IOM methods performed by otolaryngologists reveals marked differences in procedure and documentation compared to published standards in neurophysiological monitoring. In addition, many otolaryngologists have failed to change their IOM coding strategies to comply with new third party payor guidelines.
(1) The absence of specialty-specific American Academy of Otolaryngology Practice Guidelines on IOM places otolaryngologists at risk for noncompliance with external standards published in the neurophysiology field. Failure to observe national standards of IOM also compromises the quality of the monitoring provided to our patients. (2) Because “ignorance of the law is no excuse,” failure to identify and comply with new IOM coding regulations places the otolaryngologist at risk for charges of “fraud and abuse” billing. Implementing both clinical and coding changes will benefit patient and physician alike.
(1) Understand how intraoperative electrocochleograpy (ECoG) is used for assessing residual cochlear function in pediatric implant recipients. (2) Appreciate the utility of electrocochleograpy in predicting speech perception outcomes.
A prospective cohort study of pediatric cochlear implant patients at a tertiary hospital was conducted starting in July 2011 and is ongoing. ECoG recordings were obtained from 77 children (89 ears) during cochlear implantation and provided a total response metric that can quantify the underlying hair cell and neural health. Follow-up speech perception tests were conducted at ≥7 months postoperatively with the phonetically balanced kindergarten (PB-k) word lists (n = 24). PB-k scores were compared to ECoG total response and other clinical and audiologic variables using multiple linear regression analysis in order to construct a parsimonious model for predicting speech outcomes.
Postoperative PB-k scores were significantly correlated with ECoG total response (
Intraoperative ECoG recordings are significantly correlated with speech perception outcomes in pediatric cochlear implant recipients and alone can account for a similar proportion of variance in speech perception when compared to other bioaudiometric factors. ECoG provides useful prognostic information about attainment of open set speech perception in children.
Describe vertigo control outcomes when intratympanic steroid injections are used for medically refractory Ménière’s disease.
A retrospective chart review was performed of patients diagnosed with unilateral Ménière’s disease at a tertiary academic center. Patients were included who underwent intratympanic (IT) dexamethasone therapy after failing initial medical treatment between July of 2007 and July of 2013. Vertigo control was defined as when patients were satisfied and did not progress to further nonablative or ablative treatment.
Forty-one patients with Ménière’s disease underwent IT dexamethasone injections after failing medical therapy. Twenty-six patients (63%) underwent more than 1 injection, with a median of 2 injections in the study population. Fifteen patients (37%) had vertigo control, at a mean follow-up time of 9 months after the last injection. Vertigo control required 1 injection in 6 patients (40%), 2 in 2 patients (13%), 3 in 5 patients (33%), 4 in 1 patient (7%), and 5 in 1 patient (7%). Nineteen patients (46%) underwent further treatment that included endolymphatic sac surgery (9), IT gentamicin (5), betahistine therapy (4), and labyrinthectomy (1). No complications of infection or tympanic membrane perforation from the injections were observed.
IT dexamethasone injection therapy can control vertigo symptoms in patients with Ménière’s disease. However, this retrospective study reports a lower control rate than that reported in previous studies. Further studies are necessary to clarify specific patient factors that would predispose towards vertigo control with IT dexamethasone.
Compare the effectiveness of treatment for acute low frequency sensorineural hearing loss (LFHL) with tinnitus and without vertigo between intratympanic dexamethasone injections (ITDI) and oral diuretics.
A total of 35 tinnitus patients with LFHL that had developed within previous 2 weeks were enrolled and randomly assigned into 2 groups: (1) treated with ITDI 4 times on each of 4 consecutive days (19 patients) and (2) treated with diuretics orally for 2 weeks (16 patients). The group assignments and the process of treatments were double-blinded. After 8 weeks, we analyzed treatment outcomes of LFHL using subjective symptom score and audiometric change.
The cure rate of ITDI group (42.1%) was significantly higher than that of diuretics group (25.0%). For subjective symptom score, there were no statistically significant differences of improvement rate in both groups (ITDI 63.2%, diuretics 56.3%). In pure tone audiometry, the improvement rate of ITDI group (73.7%) was significantly higher than that of diuretics group (62.5%). There was a significant correlation between the cure rate and duration of symptoms.
ITDI is a more effective treatment modality than oral diuretics for LFHL within 2 weeks of development. Duration of symptom affects the cure rate of acute LFHL with tinnitus and without vertigo.
There is no study regarding the effects of low level laser therapy (LLLT) on cochlear after noise-induced hearing loss (NIHL). The aims of this study were to (1) elucidate the ability of LLLT applied to noise-induced damaged cochlea to recover NIHL and (2) demonstrate histopathological changes of remaining outer hair cells (OHCs).
A total of 6 rats (C group) for control and 9 rats (N group) as the noise-exposure group were included. Nine rats were exposed to noise once and the left ears (NL side) were treated with low-level laser daily. Right ears (N side) were the control sides. Hearing thresholds were observed through auditory brainstem response recordings. Thresholds were monitored before noise exposure and also after the twelfth irradiation. Cochlear pathology and number of OHCs were observed by scanning electron microscopy.
The initial average hearing threshold levels were 26 ± 4, 24 ± 5, 24 ± 5, 24 ± 3, 24 ± 5 dB SPL in 4, 8, 12, 16, 32 kHz, respectively. After noise exposure, N group thresholds were 63 ± 15, 64 ± 16, 71 ± 11, 73 ± 15, 67 ± 14 dB SPL. After 12 irradiations, NL side thresholds recovered significantly (27 ± 4, 26 ± 4, 28 ± 8, 30 ± 9, 27 ± 6 dB SPL,
This study demonstrates that LLLT promotes recovery of hearing and OHCs survival from apoptotic changes by NIHL.
(1) Describe the otoprotective mechanisms involved in common otoprotective drugs (ie, NAC, dexamethasone, and mannitol). (2) Describe the otoprotective effect of combining these drugs to prevent hair cell (HC) losses.
Cochlear explants were dissected from P-3 rats and placed in serum-free media. Explants were divided into 3 groups: (1) untreated controls; (2) electrode insertion trauma (EIT); (3) Tri-therapy (L-NAC + DXM + mannitol). Cochlea of groups 2 and 3 were implanted and HC counts, oxidative stress and cleaved caspase-3 markers were studied in all explants post EIT.
There was a significant increase of HC loss in the EIT explants as opposed to control or the tri-therapy cochlea. The implantation resulted in an increased production of the total reactive oxygen species (ROS) in both HCs and the supporting cells (SCs) of only EIT group. There is also cleaved caspase-3 activation in EIT cochlea as compared to the control or tri-therapy cochlea.
The tri-therapy combining NAC, dexamethasone, and mannitol has an otoprotective effect on survival of hair cells and support cells post–cochlear implantation. This in vitro oto-protection needs to be tested in vivo, in an animal model of cochlear implantation trauma.
(1) Could preoperative air-bone gap (ABG) magnitude act as a predictor of postoperative outcome in patients undergoing stapedectomy for otosclerosis? (2) If this were to occur, is it frequency specific?
Retrospective case series from January 2010 to December 2012 in a tertiary London teaching hospital. Intervention: Laser stapedectomy using Smart Nitinol stapes prosthesis. Main outcome measure: Audiometric. Retrospective analysis comparing preoperative and postoperative air-bone gap in 302 patients undergoing stapedectomy. Patients were stratified into subgroups according to their preoperative ABG and this was compared to their postoperative result of air-bone closure. In addition, for each commonly tested frequency (0.5, 1, 2, 3, 4 kHz) the preoperative and postoperative air-bone gap were analyzed in order to ascertain whether the preoperative ABG could act as a predictor. Having not passed normality testing, Wilcoxon matched paired signed rank test and Spearman rank coefficient were used for analysis.
Throughout the statistical analysis, preoperative ABG correlated most strongly with net difference in postoperative ABG (
In performing stapedectomy for otosclerosis, our series suggested the preoperative ABG may have a role in preoperative patient counseling and consent but is unable to predict success in stapedectomy surgery.
Correlate tinnitus pitch to the audiometric frequencies of hearing loss.
This cross-sectional study evaluated 378 ears of consecutive patients diagnosed with hearing loss and chronic tinnitus of any etiology. Audiometry and acufenometry were performed at the first clinical evaluation; a tinnitus pitch within the frequencies of greatest hearing loss indicated a positive association. The acufenometric frequency was similarly assessed relative to the greatest hearing loss on audiometry. Data were compared using the Spearman correlation test and analyzed using SPSS.
In total, 61.6% of patients were female, and the mean patient age was 57.9 years. In 58% of cases, the tinnitus frequency was within the region of greatest hearing loss, but only 20% corresponded exactly to the highest hearing loss frequency. There was a weak correlation (
The tinnitus pitch and the region of audiometric loss were correlated in most patients. In several cases, the tinnitus pitch corresponded to the exact frequency of greatest hearing impairment, and the 2 variables had a weak association.
Our study aims to determine the immunostaining pattern of Kir4.1 channels in human cochlear tissues. Potassium recycling pathways critical for maintaining cochlear ion homeostasis and the endocochlear potential have been defined largely in animal models. Potassium effluxed from sensory hair cells is taken up by supporting cells and returned to the stria vascularis via two distinct transcellular syncytial networks consisting of epithelial cells and spiral ligament fibrocytes. The inward rectifying potassium channel Kir4.1 appears to be an essential component of this process, as evidenced by murine knockout models lacking an endocochlear potential. Animal models have demonstrated robust Kir4.1 expression in several cell types along the cochlear potassium recycling pathway. However, Kir4.1 immunostaining patterns in the human cochlea remain undefined.
Postmortem human temporal bones were collected through the Hearing Research Program at the Medical University of South Carolina. Temporal bones were fixed within 6 to 11 hours of death and underwent microwave decalcification prior to immunohistochemical staining for Kir4.1.
Robust Kir4.1 immunoreactivity was present in strial intermediate cells, outer sulcus root processes and glial cells in Rosenthal’s canal. The distribution of Kir4.1 in the human cochlea was generally similar to that reported in animal models.
Our findings suggest that Kir4.1 channels play a critical role in the regulation of potassium recirculation in the human cochlea. Further immunohistochemical analyses are necessary to fully delineate the precise location of Kir4.1 in the complex potassium recycling pathway and elucidate its potential role in lateral wall degeneration and associated hearing loss.
(1) Evaluate gravity receptor function using vestibular evoked potentials (VsEPs) recordings in different strains of mice. (2) Indicate functional variation in VsEPs response parameters across strains for the Genome-Wide Association Study (GWAS) mapping of the vestibular system.
Mice (6 weeks old) were anesthetized with ketamine 100 mg/kg and xylazine 10 mg/kg and were positioned supine with the head mount coupled and the cranium securely fastened to a mechanical shaker. Stimuli consisted of linear acceleration (17 pulses/s) applied to the cranium in the naso-occipital axis. The first (P1) and second (P2) positive and negative response peaks were measured as phenotypes. Mice were selected based on a combined set of classic inbred (CI) and recombinant inbred (RI) strains from the Hybrid Mouse Diversity Panel (HMDP). A total of 13 CI (C57BL/6J, FVB/NJ, Balb/cJ, C3H/HeJ, Balb/cByJ, AKR/J, 129x1/SvJ, A/J, DBA/2J, SJL/J, CBA/J, SEA/GnJ, and NOD/ShiLtJ) and 10 RI (BXA14/PgnJ, BXD84/RwwJ, BXH19/TyJ, BXH22/KccJ, BXH9/TyJ, BXH10/TyJ, BXA14/PgnJ, BXA4/PgnJ, BXA16/PgnJ, and CXB9/HiAJ) were evaluated with an average of 2.7 mice/strain.
A wide range of phenotypic responses was observed. The mean threshold (–8.73 ± 5.1 dB re: 1 g/ms) and P2-N2 amplitude at +6 dB re: 1 g/ms (0.682 ± 0.51 mV) both demonstrated statistical significant variation (analysis of variance) in VsEP thresholds (
These data demonstrate significant variation in VsEP response parameters across strains, strongly suggesting the hypothesis that there exists functional variation of vestibular function among strains of mice and the genetic determinants of such variation can be mapped using GWAS.
Investigate rates of long-term use of cochlear implants (CI) in a large, consecutive case series of older adults (≥ 60 years) and characteristics associated with continuing CI use.
From 1999-2011, 447 individuals ≥60 years received their first CI at Johns Hopkins, and we successfully contacted 397 individuals (89%) to ascertain data on the individual’s daily CI use averaged over the past 4 weeks. Regular CI use was defined as ≥8 hours/d. We investigated the time from implantation to the date when an individual reported discontinuing regular CI use with Kaplan-Meier and Cox proportional hazard analyses.
The overall rate of regular CI use at 13.5 years of follow-up was 82.6% (95% confidence interval: 72.5-89.3%). Individuals who received a CI at 60-74 years had significantly higher rates of regular CI use at 13.5 years of follow-up (91.1%, [95% confidence interval: 83.2-95.4%], n = 251) than individuals who received a CI at ≥75 years (55.7%, [95% confidence interval: 24.9-78.1%], n = 146). The rate of discontinuing regular CI use (<8 hours per day) increased on average by 7.8% (95% confidence interval: 3.0-12.8%) per year of age at implantation.
Rates of long-term CI use in older adults at >10 years of follow-up exceed 80%. The rate of discontinuing regular CI use was strongly associated with older age at implantation. These results suggest that the earlier implantation of older adults, once critically low levels of speech recognition are present, is associated with greater usage of the device.
Review the long-term outcomes of cross-hatching Eustachian tuboplasty (ChEt) in patients with chronic obstructive Eustachian tube dysfunction (COETD), as well assess the clinical factors associated with surgical success.
Case series with chart review in a tertiary health care institution. This is a retrospective review by the senior author of all cases of patients who had non-revision ChEt for COETD. Follow-up period was 5 years. The curvature of the posterior cushion was modified using an argon laser to alter the spring of the cartilage alleviating the obstructed valve’s aperture. Several clinical factors were reviewed in relation to the successful opening of the Eustachian tube valve.
One hundred twenty patients, 72 males/48 females, average age 42.4 + 2 years old, met inclusion criteria to the study. COETD patients/obstructive causes were: Posterior cushion hypertrophy, 68 (56.6%). Tensor Veli and Levator Veli Palatini muscles hypertrophy, 15 (12.5%). Mucosal hypertrophic disease, 37 (30.8%). Total treated tubes was 198, bilateral 143 (72.2%), 55 unilateral (27.7). ET valve was seen more open postoperatively on simple endoscopy (SE) and slow motion video analysis (SMVEA). There were no complications. Mean pure tone average improved by 20 dB postoperatively;
High rates of improvement (96%) were found. Therefore, ChEt is a promising technique for the treatment of COETD.
Present the results of a 5-year longitudinal study in a pediatric population undergoing cholesteatoma surgery using a canal wall down approach with obliteration.
Prospective longitudinal study in a district general hospital from 1999 to 2013.46 children (<16 years) with cholesteatoma were included. Outcome measurements were: (1) residual, recurrence, and recidivist cholesteatoma rates at 5 years postsurgery; (2) postoperative hearing; (3) postoperative waterproofing of the ear; (4) number of subsequent ear surgeries required.
Using Kaplan-Meier analysis, the residual cholesteatoma rate at 5-years post-surgery was 6.7% at a rate of 20.9 per 1000 years of child follow-up (95% confidence interval: 7.8-55.6), representing 4 cases of residual cholesteatoma and no recurrences. No children experienced otorrhea at 5 years and the rate of definitive waterproofing was 94.8%. There was a reoperation rate of 18.3% (n = 11) at 5 years, which included planned ossiculoplasty. Regarding hearing, of the data available (n = 17), 12 children (70.6%) preserved maintained their hearing (change between –10 to =10 dB), 1 child (5.9%) had hearing gain (>10 dB), and 3 children (17.6%) had hearing reduction at 12 months postoperation. Six out of 17 children (35.3%) had a postoperative hearing level of ≤30 dB.
The use of a canal wall down approach with obliteration of the mastoid cavity to surgically treat cholesteatoma is safe in pediatric populations and results in a low recurrence rate and high rate of a trouble-free ear in the long term.
Correlate the findings of preoperative magnetic resonance imaging (MRI) and computed tomography (CT) in temporal bone carcinoma with histopathological findings following lateral temporal bone resection.
In this retrospective review, 11 cases of temporal bone carcinoma over the past 3 years were reviewed at our institution. Preoperative CT and MRI scans were systematically reviewed for tumor involvement in 10 anatomic areas involving and surrounding the temporal bone. These were compared with results found on final histopathology.
Among the 11 cases, 30 anatomic areas of tumor involvement identified on CT imaging were also found on MRI and confirmed on final histopathology. Two areas suggestive on tumor involvement on CT and MRI (parotid gland and regional lymph nodes) and 2 areas on MRI alone (mastoid antrum and middle ear) were negative on final histopathology. MRI did not change the preoperative clinical staging in any of the 11 cases, however, examination of the MRI in 1 case suggested temporal lobe involvement that was not seen on CT images and subsequently changed the management of the patient.
The addition of MRI in the preoperative evaluation of these patients confirmed the extent of tumor involvement seen on CT and did not identify additional tumor or facial nerve involvement in most cases except for one advanced case. In this case, the addition of the MRI findings changed the treatment plan. While CT remains the imaging gold-standard for preoperative evaluation and staging, MRI should be obtained in evaluating advanced temporal bone tumors.
(1) Assess the safety of 1.5 T magnetic resonance imaging (MRI) in pediatric patients with cochlear implants (CIs) and internal magnets. (2) Assess artifacts created by CI magnets.
A retrospective chart review was performed of pediatric CI patients who underwent 1.5T MRI at a university children’s hospital. Binding of the CI magnet was performed before MRI, using mold material and a compressive gauze dressing. Patients were assessed for ability to complete the MRI, imaging artifact from the CI magnet, magnet position, and CI function following MRI.
Four patients (mean age 65 months; range, 19-108 months), and a total of 6 CIs (2 bilateral), underwent 1.5 T MRI scans. There were 3 brain MRI studies and 1 spine. Informed parental consent was obtained. Clinical indications included leukodystrophy (2), hypertonia (1) and dystonia (1). Devices from 2 manufacturers were scanned. A CT scan was performed before the MRI scan in three-fourths of patients to assess bone thickness adjacent to the magnet. Three patients had MRI under anesthesia. The CI produced an artifact with a mean maximal AP dimension of 10.8 mm (range 7.5-15 mm) and a transverse of 5.7 mm (range 5.5-6 mm). Greatest image distortion occurred with bilateral implants. There was no change in magnet position or CI function after the MRI in all cases.
Pediatric patients may safely undergo 1.5 T MRI after CI without removal of the magnet if the device is tightly bound beforehand and strict safety protocols are followed. There are limitations to brain imaging due to artifacts.
(1) Compare longitudinal changes of Varicella-zoster virus (VZV)-specific cell-mediated immunity (CMI) in Hunt syndrome with Bell’s palsy using IFN-γ enzyme-linked immunospot (ELISPOT). (2) Examine the role of VZV-specific CMI for VZV reactivation in the facial nerve in Hunt syndrome.
This prospective study was conducted in our tertiary referral hospital between 2010 and 2013. Nineteen Hunt syndrome and 59 Bell’s palsy patients were enrolled. Mononuclear cells isolated from whole blood were incubated with VZV antigen in culture plates for 40 hours. Anti IFN-γ antibody was added and the ELISPOT system counted immunostained spots indicating VZV-specific CMI. The relationship between the spots and days from the onset of palsy were compared between Hunt syndrome and Bell’s palsy patients.
Immediately after the onset, the number of spots in the Hunt syndrome group was much lower than in the Bell’s palsy group, indicating low VZV-specific CMI. However, it increased rapidly and showed a strong positive relationship between the number of spots and days from the onset of palsy (
These results suggest that low CMI to VZV may play an important role in VZV reactivation in the facial nerve, thus leading to facial palsy in Hunt syndrome. VZV vaccination is considered to be a candidate to promote VZV-specific CMI for the prevention of Hunt syndrome.
One of the most important factors in the success of myringoplasty is the size of the perforation. The repair of subtotal and large central perforation is less likely to be successful compared with the repair of small perforations. Loop overlay technique of myringoplasty offers an advantage in these situations and can be a viable alternative.
A prospective controlled study from January 2010 to December 2011 of inactive (mucosal) chronic otitis media with subtotal and large central perforations. Subjects: Forty cases of either sex in the age group of 18-40 years. Pt. B.D.S Post graduate Institute Medical Sciences Rohtak, India, a tertiary care center. Patients were randomly divided into 2 groups of 20 each. Group A underwent medial myringoplasty and Group B Loop overlay myringoplasty. The graft uptake rate and the preoperative and postoperative hearing thresholds in each group were analyzed. Independent variables: Size and location of the perforation, preoperative air bone gap, technique of myringoplasty used.
The overall graft take-up rate in group A was 90% and in group B it was 95%. Further, the average postoperative gain in group A was 16.25 dB as compared to 18.5 dB of group B.
Loop overlay myringoplasty is better than medial myringoplasty in subtotal and large central perforations.
(1) Assess the marginal perforation prevalence in patients with chronic otitis media (COM). (2) Analyze evidence suggesting prior moderate or severe tympanic retractions (TM) of the pars tensa in marginal perforation cases. (3) Correlate the abnormal findings with those in the contralateral ear (CLE).
Prevalence study. The bilateral videotoscopies of 1510 patients diagnosed with COM in a tertiary hospital were analyzed. Previous TM retraction was evaluated according to: (1) medialization of the manubrium of malleus, (2) remnant tympanum adhered to the ossicular chain, (3) remnant tympanum adhered to the promontory, and (4) ossicular chain erosion. The videotoscopies of the CLE were also described.
Of the 1510 patients evaluated, 34 (2.25%) had marginal TM perforation. Only 5.9% of ears showed no evidence of previous retraction, and 88.3% showed 2 or more abnormal findings. The CLE was diagnosed with perforation-retraction (2.9%), moderate or severe retraction (52.9%), and cholesteatoma (14.7%); 23.5% were normal.
The study population had a low marginal perforation prevalence. The vast majority of ears with marginal perforation had evidence suggesting previous TM retraction. In addition, retraction or cholesteatoma occurred in 70.5% of CLE.
Present outcomes of children with X-linked stapes gusher (XLSG) syndrome managed at a single institution.
A retrospective evaluation of children with radiographically confirmed XLSG was undertaken. Additionally, an analysis of surgical complications and speech perception outcomes in the published literature was carried out.
Eight male children with XLSG identified in the first year of life were included in the single institutional review. All demonstrated varying levels of mixed hearing loss with present acoustic reflexes. There was no associated medical comorbidities or intellectual disability. The average pure tone average (PTA) at initiation of care was 90 ± 14 dB HL. All patients were initially managed with conventional amplification and 4 went on to receive cochlear implants (mean age 7 years). Speech perception abilities were variable amongst the implanted children (PBK range = 8-84%) despite radiographically confirmed electrode placement. One patient was too young to test. Children using amplification alone (n = 4) also demonstrated variable results. Literature review identified 21 other XLSG patients with cochlear implants (1 bilateral). Surgical complications included 4 postoperative cerebrospinal fluid leaks, 4 electrodes placed into the internal auditory canal, 2 electrode extrusions, and one device failure. Speech perception testing revealed 12 patients with open set abilities, 3 with closed set abilities, and 5 with only sound detection.
Some children with XLSG can be managed with amplification alone. Cochlear implantation, while possible, presents issues with electrode placement, cerebrospinal fluid management and variable outcomes. Careful planning is needed in children with XLSG to minimize risk and optimize outcomes.
Prevention of “a problem cavity” following modified radical mastoidectomies (MRM) and canalplasties requires careful preoperative consideration and an adept surgical technique. We aim to describe our technique of a superiorly-based middle temporal artery flap, with an inferiorly-based musculoperiosteal flap, in combination with a Corner-Tag-meatoplasty, and to evaluate the surgical outcomes on a semi-quantitative scale.
Retrospective consecutive case review from 2010-2013. Primary end-point measure of creating a low maintenance dry mastoid cavity was graded using Merchant’s grading system.
Twenty-four patients (13 males and 11 females) with a mean age of 42.6 years (range, 17-76 years) were included. All except 3 cases were primary ear cases. None had previous reduction procedures done. Nineteen cases were MRMs, 3 were revision mastoidectomies, and 2 were canalplasties. A well-epithelized, dry mastoid cavity was achieved in 12 patients by 1-month post surgery, with another 9 achieving this by 3-months. Twenty-three cases (96%) resulted in cavities with adequate control of infection based on Merchant’s summary grade. The cavities took an average of 1.75 months to epithelize. Three patients had recurrent tympanic membrane perforation with one requiring revision surgery. None had disease recurrence at mean 15.8 months follow-up (range, 6-25 months). Our technique of meatoplasty allowed excellent visualization of the mastoid bowl affording bimanual instrumentation in the clinic setting.
The middle temporal artery and inferior musculoperiosteal flap in combination with the Corner-Tag meatoplasty is an effective technique in reducing the mastoid cavity, aiding epithelization, has low complication rates, and allows good surveillance postoperatively.
(1) Identify intracellular signaling pathways required for translating biophysical cues into directed neurite growth. (2) Describe the role of TRPVI channels as mediators of cell response to microtopographical features.
Microscopic parallel grooves were generated on methacrylate polymers using photopolymerization. Spiral ganglion neurites (SGNs) were cultured on the polymers, and alignment to grooves was quantified using a ratio of aligned length to total neurite length. Control alignment was compared with that of SGNs treated with RhoA activator, RhoA inhibitor, ROCK inhibitors, cAMP and cGMP analogs, and TRPV channel inhibitors. RNA interference was used to reduce expression of ROCK and TRPVI to confirm that activity of each was required for alignment. Alignment of NIH3T3 fibroblasts was compared to fibroblasts transfected with TRPVI.
Neurites aligned preferentially to micropattern grooves. RhoA activator and cGMP analogs increased alignment, while RhoA inhibitor and cAMP analogs decreased alignment. ROCK inhibitors decreased neurite alignment, and SGNs transfected with ROCK-targeted oligonucleotides also displayed reduction in alignment. Neurites exposed to TRPV inhibitors exhibited poor alignment, as did TRPVI knockdown cells. TRPVI-transfected fibroblasts aligned more strongly than NIH3T3 fibroblasts. For all alignment comparisons,
Microtopographic features generated via photopolymerization of methacrylate polymers activate RhoA and ROCK through TRPVI channels to direct cell and neurite alignment.
Profound SNHL responds well to a standard cochlear implant (CI) with rewarding results. However, if the individual has residual hearing in the low frequencies there is a reasonable chance that the pure tones will be lost. Hybrid cochlear implants have been suggested as a solution for this problem. Unfortunately, there continues to be a loss of the low frequency pure tones in a large number of these patients.
One solution would be to use a middle ear implant instead of a hybrid CI. The Maxum middle ear implant has the advantage of being a minimally invasive surgical procedure that can be performed under local anesthesia. A small magnet is attached to the stapes through a transcanal approach.
After 3 weeks an integrated processor coil (IPC) is inserted into the external auditory canal. The IPC has an electromagnet driver. By driving the stapes directly it is possible to obtain as much as 60 dB of functional gain in the high frequencies without distortion, acoustic feedback, or the sensation of occlusion.
For these reasons the author believes a Maxum should be considered in these patients before a Hybrid Cochlear Implant. If the SNHL progresses, then a CI can still be performed at a later date. This sequence of events delays the invasion of the cochlea and in some cases prevents the need for a CI altogether.
(1) Measure stapes height, footplate height (diameter perpendicular the crural plane), and footplate width (diameter in the plane of the crura) and to correlate these metrics between right and left sides. (2) Correlate stapes measurements with mastoid size, an indicator of childhood otitis media.
From a group of 41 clinically normal ear cadavers, tissue blocks from the five crania with the largest mastoid pneumatization and 5 with smallest mastoid pneumatization were selected for micro computed tomography imaging. Using the ImageJ software package, a 3-dimensional model of each stapes was created to determine stapes height and footplate dimensions. Of 60 measurements sought, 52 were accomplished.
The mean stapes height was 3.43 mm (range, 3.18-3.82 mm). The mean stapes footplate width was 1.23 mm (range, 1.10-1.50 mm). The mean footplate height was 2.72 mm (range, 2.5-2.98 mm). Bilateral symmetry of dimensions was found, but there was no correlation with mastoid size.
A wide range of stapes dimensions is confirmed by these specimens. Bilateral symmetry suggests that genetic influences may play a role in development. No correlation was found between stapes dimensions and mastoid size, suggesting that this local environmental aspect may not be related to its development.
(1) Develop a task simulator for myringotomy and pressure equalizing tube insertion. (2) Develop a simulator that can be used to hone a participant’s micro surgical skills.
Study conducted from October to November 2013. A design for a model head with a core made up of wood and polyester body filling was made. The external facial features were replicated using molding clay. The pinna and the external auditory canal were then made from carved wood. The external auditory canals were continuous with the core of the head model. Rubber fittings were used to attach the wooden pinna to the head in order to allow some degree of mobility to the pinnae. A port at the occipital portion of the head was made that would accommodate a middle ear cartridge. A solution bottle’s cap was used to fabricate the middle ear cartridge. The tympanic membrane was simulated using a single sheet of polyethelene film. Myringotomy, tube insertion, and evacuation of middle ear fluid was done several times.
We were able to construct a simulator for doing myringotomy, evacuation of middle ear fluid, and tympanostomy tube insertion. The simulator was sturdy, easy to use, and economical.
Simulators allow constant practice and objective evaluation of skills without risks to the patient under the hands of the surgeon still on the learning curve. The creation of this simulator is a step towards the improvement of surgical training, evaluation of residents, better health economics, and patient safety.
Recent studies show that the expression of brain-derived neurotrophic factor (BDNF) is decreasing in patients with depression and severe tinnitus. However, the relationship between the incidence of tinnitus and the role of BDNF remains unclear in auditory cells. The aim of this study is to consider the molecular network of tinnitus focusing on BDNF signal and autophagy in auditory cells.
We used auditory cell line (HEI-OC1) in this study. Tunicamycin was used as endoplasmic reticulum (ER) stress. The viability of HEI-OC1 was determined by cell viability assays. Morphological observation was performed under transmission electron microscope (TEM). Western blot analysis was performed.
The cell viability after treatment of tunicamycin was decreased in dose- and time-dependent matter. Autophagosomes and autolysososmes were confirmed into the cytoplasm of HEI-OC1 under TEM. The expression of LC3-II was increased in HEI-OC1 after treatment of tunicamycin. These results mean that autophagy was consistently induced in tunicamycin-treated cells. The expression of CHOP was decreased after peaking at 12 hours after the treatment of tunicamycin. The expression of BDNF, which has the potential to become a biomarker of tinnitus, and calcium-dependent activator protein for secretion 2 (CAPS2) that promotes BDNF section, were decreased in tunicamycin-treated cells. The expression of Bcl-2 that control apoptosis and Beclin1 that regulate autophagy were decreased in tunicamycin-treated cells.
Our results lead to the suggestion that the autophagy-mediated regulation of cell death and molecular network focusing on BDNF signal play a major part of the incidence of tinnitus.
The likelihood of recurrent retraction and adhesion of newly formed tympanic membrane is high when normal middle ear mucosa is extensively lost during intractable middle surgery. If rapid postoperative regeneration of the mucosa on the exposed bone surface can be achieved, prevention of recurrent tympanic membrane adhesion and cholesteatoma formation can be expected. The aim of this study was to develop a new method to transplant autologous cell-sheets to promote postoperative regeneration of the middle ear mucosa.
We harvested 10-by-10-mm specimens of inferior turbinate mucosal tissue from the patient with acquired middle ear cholesteaoma. Tissue-engineered epithelial-cell sheets were fabricated ex vivo by culturing harvested cells for 3 weeks on temperature-responsive culture dishes in a cell-processing center (CPC) according to good manufacturing practice guidelines. After canal wall up tympanoplasty with mastoidectomy had been performed, sheets of cultured autologous cells that had been harvested with a simple reduced-temperature treatment were transplanted directly into the exposed bone surface of middle ear cavity from which normal mucosa had been absent.
During the cultivation, the sterile environment in the CPC was confirmed. Autologous cell sheets were successfully transplanted to human middle ear.
This is the first clinical study approved from the Ministry of Health, Labour and Welfare in Japan. Furthermore this is a first-in-man study in the world in which cultured cells were transplanted to the human ear. This novel technology of transplantation might be an effective alternative to the surgical operation on intractable otitis media in the near future.
(1) Image the Eustachian tube (ET) lumen by computed tomography (CT) scanning during ET function (ETF) testing, (2) characterize the differences in image quality for different scanning protocols, and (3) establish a novel research methodology for studying ET anatomy and physiology.
In a cadaver head without craniofacial or otologic abnormalities, the tympanic membrane was perforated and ETF test was done using the forced response test (FRT) in a CT scanner. Opening (OP), steady (PS), and closing (CP) pressures were measured during forced air flow from the middle ear (ME) to the nasopharynx across the open ET. Temporal bone CT scans with continuous 0.625 mm thickness were done at a low and standard radiation doses before and during the steady flow (SF) phase of the FRT, after instilling iodinated contrast into the ME and ET, and after the FRT cleared the contrast from the ET. Image analysis was done using the CT scanner console software to view the ET and peritubal structures in standard views and after image reconstructions.
The average OP, PS, and CP values were 488 ± 249, 376 ± 101, and 211 ± 62 daPa. While a distinct ET lumen could not be demonstrated during the FRT done with air, CT with intra-luminal contrast clearly demonstrated the entire ET lumen. Post-contrast FRT demonstrated residual contrast outlining the lumen.
Standard temporal bone CT doses provided a slightly better signal-to-noise than the low-dose CT for the air but not for the contrast. Combining ETF testing and CT imaging has potential research applications.
(1) Evaluate the risk of ossicular chain trauma and injuries due to different middle ear endoscopic techniques and maneuvers. (2) Describe types, incidence, and causes of these injuries. (3) Suggest methods to avoid them.
Thirty temporal bones were approached using 0°, 30°, and 70° otoendoscopes with 2.7 mm and 4 mm diameters. Three areas were systematically approached in each bone: retrotympanum, protympanum and epitympanum. They were also manipulated using 3 sets of otologic surgical instruments: regular straight, regular curved and especially designed for endoscopic ear surgery.
The most common injury was the fracture of the posterior stapedial curs (27%). Other types were incudostapedial joint dislocation (23%), fracture of foot plate (23%), stapes dislocation (17%), fracture both stapedial crura (13%), fracture of the incus long process (6%), and incudomalleolar joint dislocation (3%). Single injuries were 44% and combined or multiple injuries were 56%. Highest incidence of injuries was with the 70° otoendoscope (89%) and with both the straight and curved regular instruments (67%). The diameter of otoendoscopes did not affect the number of injuries. Positioning of the scopes and familiarity with the technique reduced the incidence of trauma.
Middle ear endoscopy can lead to a significant risk of ossicular chain injuries with their sequelae on hearing. Minimizing this risk necessitates adequate familiarity with the anatomy, techniques and otoendoscopes and usage of especially designed surgical instruments. In addition, combining both microscopic and otoendoscopic approaches or surgically assisted otoendoscopic approaches can reduce this risk considerably.
(1) Describe the disease process in giant cholesteatomas, a rare, destructive condition with significant morbidity. (2) Review recent experience in the management and outcomes of giant cholesteatoma.
Retrospective case series at a tertiary hospital-based academic medical referral center from 2004 to 2011. Three patients with giant temporal bone cholesteatoma who were surgically treated were identified. All 3 patients underwent surgical management with wide exteriorization and routine postoperative debridement. Control of disease was measured through recurrence as seen on follow-up.
Three adult male patients presented with giant unilateral acquired petrous cholesteatomas over an 8-year period. Two presented with anacusis and facial paralysis, and one with extension of disease to the sphenoid sinus. All were managed with mastoidectomy wide exteriorization; one required an additional staged endoscopic transsphenoidal approach. Hearing and facial function was preserved when present preoperatively. One patient died 5 months postoperatively from H1N1 infection unrelated to his cholesteatoma. Routine postoperative debridement maintained disease control. Follow-up ranged from 5 months to 7 years.
Exteriorization of giant petrous cholesteatoma combined with routine postoperative debridement is a safe and effective way of preventing long-term complications and disease recurrence.
Otitis media with effusion (OME) is a common problem that generally affects children ages 6 months to 3 years. There are various otoscopic signs that indicate effusion, and the findings on tympanometry may help to diagnose OME. The aim of this ongoing study is to evaluate response to clinical treatment based on tympanometry.
Prospective noncontrolled clinical assay of 25 patients with OME diagnosis, treated with oral antibiotics and nasal topical steroids from January 2013 to January 2014 in the otolaryngology department of Juiz de Fora Medical School in Brazil. The inclusion criteria were age from 2 to 12 years and signs of effusion on otoscopy and tympanometry. The exclusion criteria were antibiotic use during the previous month and history of chronic otologic disorder or congenital anomalies. The subjects were evaluated by tympanometry at the time of diagnosis and on day 30.
A total of 25 patients included 11 girls and 14 boys (3-15 years old). Of the 50 ears assessed at the time of diagnosis, 28 (56%) had curve B and 22 (44%) had curve C. After 30 days, only 8 ears (16%) remained with curve B, 12 (24%) had curve C and 30 (60%) had curve A.
Tympanometric results show that oral antibiotics associated with nasal topical steroids was effective in treating OME. Although watchful waiting is a recommendation of guidelines, there was a need for antibiotics because of upper airway infection. In developing countries access to medical attention could limit frequent consultations and lead to higher morbidity of untreated children.
(1) Describe how osteonecrosis of the temporal bone can present as a potentially life-threatening side effect of bisphosphonates. (2) Recognize that bisphosphonates are commonly prescribed and as such many of our patients could potentially experience these complications. (3) Apply this knowledge to achieve a timely diagnosis and to ensure patients are counseled regarding the risk of temporal bone osteonecrosis.
Case study of 2 patients presenting to our clinic in Lanarkshire, Scotland, from 2012-2013: Patient A: A 53-year- old female with cholesteatoma was also receiving intravenous bisphosphonate therapy for osteoporosis. Patient B: A 57-year- old female on bisphosphonates presented with a left-sided facial palsy.
Patient A: During mastoidectomy the whole of the tegmen was noted to be brittle. A large piece of tegmen was found detached from the surrounding bone but was not affected by cholesteatoma. The tegmen defect was repaired and the patient is being followed up. Patient B had examination findings in keeping with otitis externa. A computed tomography scan demonstrated bone erosion involving the descending facial nerve. Comorbidities have prevented surgical management and despite discontinuing the bisphosphonate. The facial palsy has not resolved.
Bisphosphonates can cause osteonecrosis of the temporal bone, including lower doses used to treat osteoporosis, especially in presence of localized infections. The otolaryngologist should be aware that complications such as tegmen erosion and facial palsy may occur. Patients with known infectious ear conditions considering treatment with bisphosphonates for osteoporosis should be counseled regarding the risk of osteonecrosis of the temporal bone.
Look for and implement guidelines for preoperative imaging requests to facilitate clinical practice and avoid medico-legal problems.
A review of contemporary English medical literature via Medline using the terms imaging, preoperative imaging, computed tomography (CT) scan/CT, magnetic resonance imaging (MRI)/magnetic resonance plus otosclerosis, chronic otitis media, cholesteatoma, simple chronic otitis, tympanoplasty/myringoplasty, and middle ear was performed. Abstracts were reviewed independently by two authors and relevant articles were then evaluated. Indications for preoperative imaging study for each pathology considered, benefits, main findings and the cost-beneficial relationship were investigated.
Few articles address this issue. Otosclerosis: 152 articles, with some of the studies referring to the assessment of activity and extension of the disease, but only 3 were related to the demand for imaging. Myringoplasty/tympanoplasty: a total of 87 items were found but only 4 address the issue of preoperative imaging evaluation. Chronic otitis media/cholesteatoma: 467 articles, with 32 approaching this subject. For each abstract evaluated, conditions were considered: the indications and relevant findings versus the diagnosis controversial aspects and the real need of the request (findings that can be easily diagnosed intraoperatively).
There is a growing number of otolaryngologists who routinely request preoperative imaging before middle ear surgery based on ambiguous criteria. The proposal for the creation of guidelines will help clinicians in their diagnostic decisions and to avoid medico-legal problems.
Sensorineural hearing loss (SNHL) is a common problem of our generation and has increased over the past decades. Normal function of inner ear hair cells is crucial for hearing. In mammals, inner ear hair cells cannot regenerate after damage. A single transcription factor, Atoh1, is sufficient and essential for the formation of a hair cell from a sensory progenitor cell. Two early otic transcription factors, Pax2 and Sox2, play a role in activation of Atoh1 and hair cell fate in inner ear progenitors. The aims of the study were (1) understand molecular basics of hair cell development; (2) learn about the underlying mechanisms that can regenerate hair cells from stem cells.
Biochemical analysis (chromatin-immunoprecipitation and luciferase assays) of the Atoh1 regulatory region responsible for hair cell fate and the upstream regulators Sox2 and Pax2. In vitro stem cell assay (cell culture) to induce hair cell fate from inner ear progenitors by manipulation of Sox2 and Pax2.
In hair cell progenitors, Sox2 and Pax2 are needed simultaneously in the same cell, where they co-bind to the regulatory region of Atoh1 to activate Atoh1 expression. Activation of Atoh1 transcription leads to a hair cell phenotype.
We show for the first time that Pax2 and Sox2 have a role in cell fate specification and that both factors act together to activate Atoh1 expression. Our data provide a mechanism that could be used in the future to regenerate hair cells after trauma in the inner ear.
Symptoms including tinnitus, otalgia, and vertigo have been reported following exposure to wind turbine noise; a condition termed wind turbine syndrome (WTS). We describe a case of an individual suffering following exposure and analyze the evidence for the detrimental physiologic effects of infrasound and low-frequency noise, thereby questioning the existence of WTS.
Case report (2013) and literature analysis on articles published within the past 10 years, conducted using the PubMed database and Google Scholar search engine, which included in their title or abstract the terms “wind turbine,” “infrasound,” or “low frequency noise.”
In our case the patient suffered with the symptoms of WTS and was able to challenge the wind turbine company in court. There is evidence that infrasound has a physiologic effect on the ear, but the overwhelming opinion emerging is that there is no clear evidence that WTS exists, and that the overriding factor is annoyance and the fiscal implications of living near a turbine or wind farm. The literature lacks any convincing evidence that low frequency noise causes significant physiological effects.
We present a case of a successful plaintiff with all the symptoms of WTS. Although there is some evidence of symptoms in patients exposed to wind turbine noise, our group feels that the symptoms of WTS are vague and can be attributed to psychosomatic factors and annoyance due to the proximity to low frequency whirring, rather than a true physiological impairment.
Osteoradionecrosis is a rare but devastating complication of radiation therapy that often requires surgical intervention. The objective of this report is to describe a case of osteoradionecrosis (ORN) of the temporal bone that was managed medically with PENTOCLO (pentoxifylline-tocopherol-clodronate). The use of PENTOCLO in the treatment of ORN of other sites in the head and neck will also be described.
We report the case of a patient treated at our institution and present a review of literature. A 52-year-old woman presented with ORN of the temporal bone 20 years following radiation therapy for an ipsilateral parotid tumor. The patient had chronic infections and otorrhea.
She failed conservative treatment including antibiotic-steroid ear drops and aural lavage. As an alternative to hyperbaric oxygen and/or temporal bone resection, treatment with PENTOCLO was pursued and her condition improved dramatically. A literature review of ORN of the temporal bone and the use of PENTOCOLO in the management of ORN of other sites of the head and neck are described.
PENTOCLO was effectively used in the management of our patient and may represent a valuable management option for other patients with ORN of the temporal bone. Further research is required to determine the effectiveness of PENTOCLO.
Recent advances in endoscopic technology have allowed an application to middle ear surgery. Anti-fog agent is necessary for endoscopy because moisture and blood may cause obscured vision. Ultrastop is one of the most commonly used anti-fog agents. The current study examined the ototoxic effect of topical application of Ultrastop in the guinea pig ear.
A preliminary experimental animal study. in a university hospital. Eighteen male Hartley guinea pigs (weight, 480-620 g) were divided into 3 groups to be treated with Ultrastop, gentamicin (50 mg/mL, positive control), or saline solution (negative control). After auditory brainstem responses were measured, topical solutions of 0.2 mL were applied through a small hole made at the tympanic bulla. Posttreatment auditory brainstem responses were obtained 14 days after the treatment. The extent of middle ear damage was investigated and scored.
The saline-treated group showed no deterioration in auditory brainstem response threshold. The anti-fog-treated and gentamicin-treated groups showed severe deterioration in auditory brainstem response threshold. Middle ear examination revealed extensive changes in the anti-fog-treated group and medium changes in the gentamicin-treated group.
Anti-fog solution (Ultrastop) applied topically to the guinea pig middle ear caused significant middle ear inflammation and hearing impairment. Great care must be taken to prevent anti-fog solution reaching the middle ear.
(1) Demonstrate gentamicin uptake from perilymph into hair cells via basolateral channels such as the postsynaptic acetylcholine receptor (nAChR) and the TRPA1 in neonatal mice in vivo and in vitro. (2) Recognize alternative gentamicin trafficking pathways to the well established endolymphatic mechanoelectrotransducer channel underlying aminoglycoside ototoxicity.
Neonatal mice were intraperitoneally injected with fluorescently-conjugated Gentamicin-Texas Red (GTTR), prior to fixation 30 minutes later. Cochlear explants were treated with GTTR 1 µg/mL, with or without 100 µM acetylcholine or cinnamaldehyde then fixed, and analyzed. Fluorescence intensities were measured by calculating the mean gray value of each cell with Image J. Student
Application of acetylcholine increased GTTR uptake by wildtype outer hair cells (OHC) in vivo and in vitro. These results were also replicated in Myo7a8J/8J mice, which lack functional mechanoelectrotransducer channels. Application of cinnamaldehyde (TRPA1 agonist) also increased GTTR uptake in OHCs in wildtype, myo7a8J/8J mice and guinea pigs.
Endolymphatic gentamicin trafficking via the mechanoelectrotransducer (MET) channel is a well established mechanism of ototoxicity. Noise-induced threshold shifts (NITS) have been shown to damage the mechanically gated tip link, thus closing MET channel. However, aminoglycoside hair cell uptake is enhanced by NITS. This suggests one or more aminoglycoside entry route(s) into hair cells in addition to, and independent of, the MET channel. The results of this study support perilymphatic trafficking of gentamicin via basolateral channels including the nAChR Ca2+ channel, and TRPA1.
(1) Characterize pitch adaptation patterns in bimodal long-electrode cochlear implant (CI) users over time, and correlate these with electrode discrimination and speech perception outcomes. (2) Compare to pitch plasticity observed in hybrid CI users.
Observational cohort over a 12-month period after CI activation or of long-term CI experience. Severe to profound hearing impairment in 19 newly activated bimodal CI users and 20 long-term CI users was studied in an audiology clinic. Outcome measures: Electric-to-acoustic pitch matches, audiometric thresholds, electrode discrimination performance, and speech perception scores, measured over time.
Recently activated (12 months) subjects had these pitch adaptation patterns: pitch-adapting, pitch-dropping, and pitch-unchanging. Long-term subjects had a parallel set of adaptation patterns: matched-pitch, low-pitch, and nonmatched-pitch. Unlike hybrid CI users who are mostly pitch-adapting/matched-pitch, the majority of bimodal CI users demonstrated pitch-dropping/low-pitch or pitch-unchanging/nonmatched-pitch. Subjects with pitch-adapting/matched-pitch patterns trended towards better low-frequency thresholds. Changes in electrode discrimination were not associated with pitch differences between electrodes. Reductions in speech perception scores over time were associated with dropping-pitch patterns.
Bimodal CI users with more residual hearing seem similar to hybrid CI users in adapting pitch perception to reduce mismatch with the frequencies allocated to the electrodes and acoustic hearing. In contrast, those with less residual hearing exhibit no adaptation or a drop in the pitches of the basal electrodes. Our data suggest that electrode discrimination does not depend on perceived pitch differences between electrodes. Speech perception may depend more on pitch perception and the ability to distinguish pitch between electrodes.
Otowicks are used to treat otitis externa with significant ear canal oedema. They ensure close contact between administered drops and the canal skin. How well drops penetrate through to reach the deep canal has not been accurately investigated. This in vitro study aims to investigate: (1) the permeability of otowicks to commonly used ear drops; (2) The ability of bacteria to penetrate through the otowick.
Sterile otowicks were inserted into mock ear canals fabricated from plastic pipettes. These were held vertically over pseudomonas-seeded agar plates while Gentisone HC or CiloxinTM drops were administered; 4 drops, TDS for 5 days. Time taken for the drops to penetrate through the otowick was recorded. Separately, pseudomonas-seeded otowicks were inserted into plastic pipettes and treated with saline or antibacterial drops. The penetrating drops were observed for bacterial growth on sterile agar.
It took 6-8 drops before penetration occurred for both ear drops. Thereafter, otowicks treated with Ciloxan showed delayed penetration after 5 days (60-240 seconds) when compared with Gentisone (50-91 seconds). When sterile saline drops were applied to bacterially-contaminated otowicks, the penetrating drops displayed bacterial growth on agar, indicating that pseudomonas penetrated through the otowicks. However, when Gentasone or Ciloxan were applied, penetrating drops showed no bacteria growth on the corresponding agar plate.
Bacteria can penetrate otowicks but this can be prevented by continuous application of antibacterial ear drops. Ear wicks need priming with 8 drops before starting a regime as the initial dose is fully absorbed by the otowick.
Nasopharyngeal colonization is the initial step in pathogenesis of pneumococcal diseases, including otitis media. Previous studies suggested that
Descriptive study conducted at Melbourne University and Murdoch Childrens Research Institute, Melbourne from 2011 to 2013. High, medium, or low numbers of
There was time-dependent and dose-dependent inhibition of pneumococcal adherence to CCL-23 cells by
Our data indicated that
(1) Recognize that bilateral cochlear implantation (CI) in X-linked deafness is surgically feasible and safe. (2) Recognize that improvement in hearing as well as language acquisition is an achievable goal.
This is a retrospective case review at a tertiary care center of one patient who presented with bilateral profound sensorineural hearing loss at age 6 months. He lacked auditory brainstem responses in both ears and was confirmed to have congenital X-linked deafness secondary to POU3F4 gene mutation. Because of lack of benefit from amplification, he underwent bilateral CI in a staged fashion at 12 (right ear) and 15 months (left ear) of age.
The patient underwent transmastoid-facial recess approach and received Nucleus Freedom implants (Cochlear Ltd) in both ears, utilizing perimodiolar electrodes. High-flow gushers were encountered bilaterally and resolved with temporalis muscle plugs. C-arm fluoroscopy was used during insertion of electrodes in both ears. Follow-up data were available for 12 months. No complications were encountered, including no postoperative CSF leakage or facial stimulation. Postoperative audiograms in aided conditions showed hearing thresholds <40 dB. At 11 months following activation of his second CI, he scored in the normal range for his chronological age on standardized language measures, the Receptive Expressive Emergent Language Test-3 and the Preschool Language Scale-5.
With careful preparation and the assistance of intraoperative fluoroscopy, cochlear implantation in patients with congenital X-linked deafness can be done safely. Performing bilateral CI followed by dedicated auditory-verbal rehabilitation may allow patients to trend toward normal language development.
(1) Estimate the degree of postoperative aeration in the middle ear after canal wall down tympanoplasty with soft-wall reconstruction (CWD tympanoplasty with SWR) for cholesteatoma. (2) Characterize the relationship between postoperative middle ear aeration and hearing outcome. (3) Propose an ideal state of middle ear aeration in order to obtain satisfactory hearing outcome after CWD tympanoplasty with SWR.
This retrospective study was conducted in our tertiary referral hospital between 2001 and 2013. Seventy-eight ears with cholesteatoma treated surgically at our hospital by planned two-stage CWD tympanoplasty and SWR were included. Postoperative middle ear aeration was scored one year after second-stage surgery by computed tomography (CT). The patients were divided into 4 bins according to postoperative audiometric air-bone (A-B) gaps: 0-10, 11-20, 21-30, and >30 dB.
Postoperative middle ear aeration was significantly greater in the smaller A-B gap bins (0-10 and 11-20 dB) compared with the larger A-B gap bins (21-30 and >30 dB). In contrast to the larger A-B gap bins, those with smaller A-B gaps showed reaeration of the antrum and mastoid cavity.
Promoting postoperative aeration of the entire middle ear is necessary to achieve better hearing outcome in patients undergoing CWD tympanoplasty with SWR for cholesteatoma. The ventilation tube insertion and placement of the large silicone sheet from the protympanum to the mastoid cavity in the first-stage tympanoplasty are candidate procedures to promote postoperative aeration.
(1) Describe the prevalence of Ménière’s disease and migraine in the United States. (2) Recognize patient and environmental factors in Ménière’s disease.
Discharge data from the Nationwide Inpatient Sample, the largest US all-payer inpatient care database, was analyzed for migraine or Ménière’s disease between 2008-2010 in patients >10 years old. Patient characteristics, including prevalence, age, sex, race, household income, and geographic location were studied to determine any correlation with disease prevalence.
Ménière’s prevalence was 73 per 100,000, females 84 per 100,000 compared with 56 per 100,000 among males (odds ratio [OR] = 1.51, 95% confidence interval [CI] 1.48-1.54,
Environmental factors, race and ethnicity, sex, and age appear to be important factors in the prevalence of Ménière’s disease.
Determine the prevalence of hearing impairment and auditory neuropathy among preterm very-low-birth-weight (VLBW) babies at 1 year corrected age.
Twenty babies were recruited. The subjects underwent transient evoked otoacoustic emission (TEOAE) and automated auditory brainstem response (AABR) at 34 to 36 weeks while they were still in the neonatal intensive care unit. The subjects were followed up with brainstem evoked response (BSER) at 3 months and 1 year of corrected age. A patient was considered to have hearing impairment if either 1 or both ears failed the test. The risk factors for hearing impairment are noted.
Thirty-five percent (14 out of 40 ears) failed TEOAE and 12.5% (5 out of 40 ears) failed AABR screen. Two babies defaulted BSER appointment. BSER at 3 months corrected age showed 5.5% (1 out of 18) with bilateral profound sensorineural hearing loss, 16.7% (3 out of 18) bilateral mild conductive hearing loss, and 77.8% (14 out of 18) with normal hearing. At 1 year of corrected age 5.5% (1 out of 18) had profound sensorineural hearing loss, 5.5% (1 out of 18) mild conductive hearing loss, and 89% (16 out of 18) had normal hearing. There was no prevalence of auditory neuropathy or progressive hearing loss in this study.
Those VLBW babies achieved maturity of hearing at 3 months corrected age, therefore no repeat BSER is required at 1 year.
(1) Describe the anatomy of Prussak’s space (PS) using the recently available data due to the incorporation of endoscopes in its studying. (2) Evaluate previously described theories about its development, physiology, aeration, and pathophysiology of its diseases.
Fifty-five temporal bones were dissected, and anatomic details were studied using an operating microscope and otoendoscopes.
PS is a 3-dimensional sagittal space located laterally and superficially to the tympanum and formed by mucosal and bony walls. Four types of PS could be distinct based on the pathways of their aeration and communication with the various spaces and areas of the tympanum, as demonstrated by the development of the mucosal folds, pouches and pathways. The first and most common type (71%) was aerated solely retrogradely via the posterior pouch of von Troeltsch. Second type (2%) was only aerated via the anterior pouch of von Troeltsch. Third type (2%) was only aerated through a special superior mucosal pathway. Spaces classified under the fourth PS type (25%) were aerated through combined or multiple pathways of the above types.
PS, unlike what has been usually thought, has different types. Although the differences between these types might look trivial, they mostly contribute in the development and progress of the space pathological conditions. This might play a role in the explanation of the PS isolated infections and also the mechanism of retraction pockets and cholesteatoma formation and the modes of their extension.
Although hearing impairment is prevalent in older adults and may carry implications for cognitive, social, and physical functioning, little is known about hearing care among older minority adults. The aims of this study were: (1) describe factors that are associated with disparities in hearing health care among older adults and (2) assess the current reach of hearing care delivery to older adults.
We analyzed nationally-representative, cross-sectional data from 1544 older adults ≥70 years with audiometry and hearing health care data from the 2005-2006, 2009-2010 National Health and Nutritional Examination Surveys. The 2 primary outcomes were recent hearing screening (≤4 years) and, for those with hearing loss, regular hearing aid use (≥5 h/wk in the past 12 months). Disparities-related covariates included demographics, insurance status, general health, and health care utilization.
Adjusting for age and better ear speech-frequency (0.5-4 kHz), pure tone average (PTA), race (odds ratio [OR] = 1.68, 95% confidence interval [CI]: 1.21-2.33, Blacks compared with Whites) and education (OR = 1.63, 95% CI: 1.05-2.52 ≥college versus <high school), were associated with having a recent hearing screening. However, hearing aid use was associated with socioeconomic status (higher education, income, poverty-to-income ratios, having private insurance), and with race (Blacks OR = 0.42 [95% CI: 0.19-0.91] and Mexican Americans OR = 0.22 [95% CI: 0.06-0.74] versus Whites). In a multivariate analysis, adjusting for age, hearing loss, race/ethnicity, and socioeconomic status, Blacks were not more likely than Whites to use hearing aids despite higher levels of hearing screening (OR = 0.74, 95% CI: 0.28-1.93).
With increasing populations of older minority adults and growing evidence of the detrimental effects of hearing loss, disparities in hearing health care represent critical areas for research and intervention.
Determine the rate of long-term cochlear implant (CI) use in children.
Consecutive case series in a tertiary referral center. Approximately 474 patients younger than 18 years who received their first cochlear implantation from 1999 to 2011. Main outcome measures: Regular CI use, defined as using the CI for 8 hours or greater per day.
We successfully contacted and obtained follow-up data on 402 patients (85%) via email, telephone, and postal survey. The rate of regular CI use was 93.2% (95% CI, 90.0-95.4) at 5 years’ postimplantation and 87.7% (95% CI, 82.9-91.3) at 10 years’ postimplantation. The mean number of hours of use per day was 12.0 hours (SD, 4.1 hours). Cox proportional hazard regression analysis demonstrated a linear association between the age at implantation and the risk of discontinuing regular CI use. Rates of CI discontinuation increased by 18.2% per year of age at implantation (95% confidence interval, 7.2%-30.4%). Reported reasons for CI use less than 8 hours per day include poor hearing benefit (53.2%), social pressure (21.3%), and recurrent displacement of the transmitter coil (17.0%).
High rates of regular CI use are sustained after childhood implantation, and younger age at implantation is associated with a higher rate of continued device usage.
This study examined the effectiveness of D-methionine (D-met) in rescuing a noise-induced permanent threshold shift (PTS) and cochlear biochemistry following noise exposure.
One hour after being exposed to continuous white noise at 105 ± 2 dB SPL for 6 hours, guinea pigs were treated 5 times at 12-hour intervals with 200, 400, or 600 mg/kg D-met or sterile 0.9% saline by intraperitoneal injection. Auditory brainstem responses were examined before and 14 days after noise exposure. Six guinea pigs with normal hearing that were not exposed to noise served as control animals. The level of D-met in rescuing noise-induced hearing loss and the changes in cochlear biochemistry, including membranous Na+, K+-ATPase, and Ca2+-ATPase, lipid peroxidation, and nitric oxide, were evaluated.
Hearing acuity had no significant differences before and 14 days after noise exposure for the animals treated with 600 mg/kg D-met, compared with the control animals, whereas significant differences occurred among the animals in the other treatment groups. The level of rescue from noise-induced PTS following treatment with D-met was dose-dependent. No significant differences in the mean enzyme activities were observed between the controls and the D-met 600 mg/kg treatment group. The attenuation of the noise-induced decreases in the enzyme activities was dose-dependent. Likewise, D-met-dose-dependent decreases in oxidative stress were observed in the D-met treated groups.
Treatment with D-met significantly rescued noise-induced PTS in a dose-dependent manner. Significant attenuation of increased oxidative stress and decreased ATPase activities were concurrent with the D-met-mediated improvements in noise-induced auditory dysfunction.
Age-related hearing impairment or presbycusis is one of the most common sensory abnormalities in the world. Mouse models have been widely used in studies of hearing loss to separate genetic and environmental influences. We will describe novel cis- and trans-regulation and dominance patterns in gene expression levels from cochlea of mice.
Next-generation sequencing (RNA-Seq) data has been acquired from cochlea of three F1 mouse hybrid strains (n = 4) from parental strains C57BL/6J, DBA/2J, C3H/HeJ.
An analysis of allele-specific expression will be reported and novel transcripts, isoforms, cis and trans-regulation, long non-coding RNAs, and dominance patterns will be discussed in relation to known genes.
This will help to elucidate mechanisms and better understand the genetic backdrop of age related hearing impairment.
Describe the surgical technique and outcome in a series of patients who underwent revision cochlear implantation using a double-array or split electrode device. All patients had an ossified cochlea due to meningitis and were functioning poorly with a standard electrode cochlear implant.
Four patients between the ages of 4-15 years underwent revision with 5 double-array cochlear implant devices in our center during the years 2010-2012. One patient underwent bilateral revision surgery. All patients suffered from meningitis with computed tomography and magnetic resonance imaging studies that demonstrated an ossified cochlea. The time interval between the disease and initial cochlear implantation was 4 months to 4 years. Patients data were retrospectively analyzed with emphasis on the surgical technique, number of electrodes inserted, and number of active electrodes at follow-up. In addition, pre and post revision surgery function was compared.
The revision surgery was carried out 4 to 10 years after the initial surgery. Two tunnels, basal and apical, were drilled in the ossified cochlea. In each of the tunnels 5 to 12 electrodes were inserted. While the number of active electrodes before revision was 0-5, after revision with the double array it increased to 8-16. This resulted in increased auditory and speech function.
The double-array device can provide good outcome in the post-meningitis ossified cochlea. In many of these cases function can be better than with a single electrode device.
Study the effect of noise exposure on the hearing sensitivity of the screened study subjects, analyze the questionnaire for noise exposure, and compare between hearing impairment in different noise exposure categories.
A total of 1879 subjects were evaluated and a noise exposure survey was completed by the study group. Screening air conduction pure tone audiogram was done for each participant. Patients who did not pass the screening were referred to the ear, nose, and throat and audiology unit for further evaluation: complete history, otological examination, pure tone audiometry, tympanometry and distortion product otoacoustic emissions (DPOAEs).
The study group’s average duration of duty was 10.26 ± 8.06 years. Of the study group, 33.9% were cigarette smokers. A total of 188 subjects out of 1879 (10%) did not pass the screening air conduction pure tone audiogram and they were referred to the audiology clinic. The mean emission amplitude across the DPOAEs measured frequencies in noise-induced hearing loss (NIHL) patients at high frequencies were significantly lower than that of the low frequencies. Also it was noticed that as the hearing loss increases at high frequencies region with the NIHL the DPOAEs amplitude decreases.
Ten percent of the high-risk noise exposed subjects had high frequency hearing loss which can be minimized by using hearing protective devices during exposure to intense noise level. Reduction in the emission amplitude of DPOAEs at high frequencies region was significant in comparison with that of the low frequencies. These differences can be attributed to the hearing loss and the patho-physiologic mechanism at the level of outer hair cells encountered in those patients.
Multiple efforts are under way to develop methodologies to allow tympanostomy tube (TT) placement in young children under conscious sedation where there can be significant head motion. This practice modification would provide an option for TT placement without the risk of general anesthesia and the potential for procedures being performed in an office.
Investigators evaluated a tool designed to perform a quick, single pass tube delivery across the tympanic membrane with a downward force of motion in a moving child under conscious sedation. Training required bench evaluation and the use of general anesthesia before performing conscious sedation cases.
A total of 176 TTs were performed in 89 children at 3 institutions. Ninety-one TTs in 46 children used general anesthesia, and 85 TTs in 43 children used conscious sedation. Conscious sedation included nitrous oxide in 35 children and midazolam plus nitrous oxide in 8 patients. All cases used phenol as a topical anesthetic. Twelve children were converted to general anesthesia for over-insertions, design challenges, anatomy, or movement. The major complication encountered was delivery of the TT into the middle ear space. Multiple tubes were used, but a beveled medial flange tube with a lateral visualization tab to provide depth feedback proved most effective for attenuating patient movement without TT over-insertion (64 children).
Early results show that TT placement in children may be done safely under conscious sedation. Additional clinical experience is required to optimize the tool and the training to prevent complications of TT placement with a single-pass device.
(1) Translate epidermal electronic systems (EES) into an implantable electrode system (IES) with the potential to detect electric activity from growing axons distal to the site of nerve repair. (2) Demonstrate baseline and stimulated activity in intact nerves using IES. (3) Demonstrate nerve activity using IES following nerve regeneration across a surgical repair site.
EES consists of thin flexible electronic circuitry that is capable of sensing and wirelessly transmitting multiple modalities including electrical activity, temperature, and stretch following transfer to skin. We have modified EES technology into an implantable electrode system consisting of biocompatible components that can detect nerve activity in vivo in a rodent model. We obtained recordings of intact sciatic nerve activity following pulsed stimulation applied via the proximal portion of the electrode array. Future experiments will focus on detection of activity following nerve transection and repair.
A first-generation IES sensor was tested on intact mouse sciatic nerves. Proximal electrodes were used to stimulate the nerve, and distal electrodes recorded the stimulus. Action potentials were successfully recorded. Recorded activity was abolished following nerve transection.
We demonstrate the adaptation of EES technology with the ability to stimulate and record nerve activity in a rodent model. An implantable device capable of sensing nerve regeneration would provide crucial information on the status of nerve repair and at much earlier time points allowed by clinical exam and electromyography. This technology has the potential to improve clinical decision-making and patient outcomes.
(1) Describe a classification for the sinus tympani (ST) different types based on their otoendoscopic and surgical anatomy in relation to their development theories. (2) Evaluate possible approaches to each of its types. (3) Eliminate the discrepancy between the various methods used to describe it in literature.
Fifty-five temporal bones were dissected, and the anatomic details were studied using an operating microscope and otoendoscopes of different angles. In addition, the ST anatomy and relations were studied in 200 temporal bones’ computed tomography scans.
Four distinct types of ST could be observed. Type 1, the most common type, was pneumatized and consisted of an orifice and cavity. In Type 2, the well-pneumatized type, the cavity was deep enough posteriorly to exceed the level of the mastoid segment of the facial nerve in any direction. In Type 3, the common posterior tympanic sinus, ST communicated with the upper posterior tympanic sinus proper or with a retro-ponticulus up-ward extension. Type 4, the nonpneumatized type, was shallow with no true orifice and cavity. Types 1 and 4 were mainly approached via the transcanal route. Types 2 and 3 required a combined transcanal and transmastoid approach. Endoscopic transcanal approach alone was satisfactory for types 1 and 4 but to a lesser extent in type 3.
ST shape and extension both depend mainly on the extent of its pneumatization, which in turn influences its relation to the surrounding structures in the retrotympanic area. Extensively or unusually pneumatized types need special or combined approaches.
Endoscopic ear surgery is rapidly gaining popularity as a minimally invasive approach to address chronic ear disease. However, little is known about the potentially damaging temperature increases associated with endoscopy in the middle ear. Specifically, neither temperature change nor heat distribution associated with the endoscope has been quantified. In this study, we aim to measure temperature changes throughout the middle ear during rigid endoscopy in a human temporal bone model.
Fresh human temporal bones were maintained at physiologic temperature during middle ear endoscopy with a 3-mm 0° Hopkins rod. Temperature changes were measured as a function of the distance between the endoscope tip and the round window membrane. Thermal gradient was determined by infrared imaging. Control studies conducted at room temperature were also performed.
An endoscope with a xenon or light-emitting diode light source on maximal power induced a rapid temperature elevation up to 46°C within 0.5-1 mm of the tip of the endoscope within 30-124 seconds. Elevated temperatures occurred at distances up to 8mm from the endoscope tip. Temperatures rapidly returned to baseline within 20-88 seconds after turning off the light source.
Our findings have direct implications for endoscopic ear surgery and affirm the importance of avoiding excessive temperature elevation. We recommend employing submaximal light intensity and repositioning the endoscope frequently to provide rapid cooling. Ongoing studies use an animal model to explore the in vivo effects of prolonged middle ear endoscopy and evaluate for potential threshold shifts in auditory brainstem responses.
Squamous cell carcinoma of the temporal bone is a rare and invariably aggressive tumor with an estimated incidence of one per million per year. Tm1 squamous cell carcinoma (SCC) is the most frequent primary malignant tumor of the temporal bone, but the incidence is as rare as <0.2% of all tumors of the head and neck. It is a rare but threat eningly aggressive tumor, with poor prognosis. Because of the rarity of this disease, there is no large prospective series on staging, treatment, and outcomes. Surgical treatment remains a challenge in the hands of skull base surgeons. The prognosis for patients with this disease has remained poor despite advances in surgical and radio-therapeutic techniques.
A retrospective review of the medical records of the patients diagnosed with squamous cell carcinoma of the temporal bone from 2000 to 2007 was performed. This study included 14 patients with unilateral temporal bone tumors.
Factors evaluated included patient demographics, presenting symptoms, physical examination findings, radiographic findings, surgical treatment, method of reconstruction, surgical complications, histopathologic findings, and the use of postoperative radiation therapy.
In this study, we developed a tangible head model for the physical treatment of benign paroxysmal positional vertigo (BPPV) and assessed the educational efficacy of this model for people. This model has a 10-time-scale mockup of the semicircular canal, which contains 10 canalith particles, located in a 1.5-time-scale mockup of the head.
This was a prospective study involving 20 medical students just starting to study otolaryngology. At first, they learned the canalith repositioning procedure (CRP) from an article. After reading the article, they tried to move 10 canalith particles from the ampulla to the utricle using the model, during which they were not able to see inside. Second, they practiced the CRP using the model, and they could see the inside. Third, they tried to move 10 canalith particles from the ampulla to the utricle using the model, during which they could not see the inside. Compare the number of canalith particles, which students can move from the ampulla to the utricle, before and after practice using the model.
Before practice using the model, they could move 2.5 (mean value) canalith particles, after practice, they could move 6.6 (mean value) canalith particles. There was a statistical difference (
It was suggested that a tangible head model for the physical treatment for BPPV is a useful educational tool for people such as resident doctors, medical students, and patients with BPPV.
We give an overview of the current state of cerebellopontine angle (CPA) surgery, based on the recent evidence, and describe our center’s experience in surgical approaches to these lesions.
Retrospective review of cases who underwent surgery for CPA lesions at our hospital during the past 17 years (1996-2013), with focus on the description of the currently most used technique-extended retrosigmoid. We also conducted a brief review of the literature on CPA surgery, comparing the different approaches, their indications and complications.
During this period, 203 patients underwent surgery for CPA. The most frequent indication was vestibular schwannoma (84.7%). Other indications were meningiomas (8.4%), epidermoids (1%), vestibular neurectomies (1.5%), arteriovenous malformations (1%), anterior inferior cerebellar artery–posterior inferior cerebellar artery aneurysms (1%), trigeminal microscopic decompression (0.5%), and other more rare tumors (2%). The most used approach was extended retrosigmoid (71.9%), followed by the translabyrinthine (26.1%) and middle fossa approach (2%). Until 2004, the most used approach was the translabyrinthine; after 2004, the most used was the extended retrosigmoid.
Currently, the preferred surgical approach used by our team is the extended retrosigmoid, because it allows a complete exposition of sigmoid sinus from the transverse sinus to the jugular bulb, enhances CPA vision, avoids cerebellar retraction, and is a simple way to get a wide route to the CPA. It also allows good functional outcomes (hearing and facial nerve preservation) in most cases. However, indications for approaches depend on the size of the lesion, its location and the quality of preoperative hearing, as well as a necessary familiarity with all approaches.
Serous otitis media is very frequent in children, especially those between 3 and 6 years of age. The diagnosis of otitis media is often difficult. Otomicroscopy and tympanometry can improve diagnostic quality by the indication of fluid in the middle ear and thereby improve the quality of treatment. The aim of this ongoing study is to describe the variations in tympanometry in patients undergoing clinical treatment alone.
This was a prospective study of 25 patients diagnosed with secretory otitis media, treated with oral antibiotics, nasal corticosteroid spray, and nasal N-acetylcystein from January 2013 to January 2014 in the Otorhinolaryngology Department, Juiz de Fora University Medical School, Brazil. The inclusion criteria were age between 2 and 12 years and altered otoscopy and tympanometric examination. The exclusion criteria were antibiotic use during the previous month and history of chronic otologic disorder or congenital abnormalities. All were evaluated by tympanometry in the week of diagnosis and after treatment, at 30 days from the first review.
A total of 25 patients, of which 11 (44%) were girls, and 14 (56%) were boys (3 to 15 years old). Of the 50 ears assessed in the first week of diagnosis, 28 (56%) had curve B and 20 (40%) had curve C. At the last evaluation, only 8 ears (16%) remained with curve B. 12 (24%) had curve C and 30 (60%) had curve A.
Treatment with corticosteroids via nasal spray combined with oral antibiotics and nasal N-acetylcysteine can be a good therapeutic option for the treatment of secretory otitis media.
Radiation therapy (RT) for head and neck cancer (HNC) may be associated with osteoradionecrosis of the temporal bone (ORN-TB). The goal of this study is to examine the incidence of ORN-TB in HNC patients receiving RT ± chemotherapy (chemo) and its association with patient- and treatment-related factors.
Pre- and post-RT records of 376 HNC patients were retrospectively assessed for the presence of possible ORN-TB. Dose received by tympanic ring was estimated using the computed tomography-based treatment plan for the patient. Uni- and multivariate analyses evaluated the association between various variables and incidence of ORN-TB.
ORN-TB was diagnosed in 27 (7.2%) patients over a median time of 9.5 years (range, 1-17 years). Of these, localized ORN-TB was observed in 18 (66.6%) patients, diffuse ORN-TB in 9 (33.3%) patients. Dose received by temporal bone ranged from 35 to 80 Gy. RT dose was significantly associated with ORN-TB (
RT dose appears to be the primary determinant of ORN-TB in HNC patients. Further prospective investigation is needed to better understand the factors that might contribute to and protect from ORN-TB.
The middle fossa approach needs the surgeon to have a 3-dimensional anatomic knowledge of internal auditory meatus (IAM), which is located underneath the middle fossa bony plate. Our purpose was to describe microsurgical anatomy of the middle fossa approach using temporal bone computed tomography (CT) 3-dimensional (3D) reconstruction.
Thirty CT images of the temporal bone from patients aged between 20 and 60 years were selected. The inclusion criterion was a radiologically normal temporal bone CT scan. 3D-reconstructed images were obtained using high-resolution axial temporal bone CT scans. IAM, semicircular canal (SCC), cochlea, tympanic segment of the facial nerve (FN), geniculate ganglion (GG), and malleus were reconstructed. The length and angle among these structures was measured.
The mean lengths between the center of IAM and bony surface of middle cranial fossa at the Porus level was 7.7 mm (±1.0). The mean length between the superior of point of IAM of porus and GG was 15.4 mm (±1.5). The mean length between superior of point of IAM of porus and medial end of cochlear basal turn 9.9 mm (±0.9). Angle between the axis of SCC and the axis of tympanic segments of FN was 105.9° (±5.4). The mean angle between the axis of SCC and axis of IAM was 47.2° (±6.5) The mean angle between the axis of IAM and axis of tympanic segments of FN 59.6° (±10.9), The mean angle of 3-point malleus handle, GG, superior point of IAM of porus level was 113.8° (±9.8).
The understanding of the 3D relationship in the microsurgical structure will help decide the drilling point for the IAM in case of lack of bony landmarks.
Even today, treatment of intractable vertigo remains a challenge. The objective of this study was to control intractable vertigo through complete vestibular ablation with intratympanic gentamicin treatment. Complete vestibular ablation was confirmed by zero response on ice water (ENG) and an absent response on vestibular evoked myogenic potentials (VEMPs).
Retrospective case study design in a tertiary care center. Subjects were patients with refractory episodic vertigo. The inclusion criteria were unilateral ear disease, moderate to profound sensorineural hearing loss, and failure to respond to other treatments. Included patients underwent 0.5-0.8 mL of gentamicin intratympanic application at a 30 mg/mL concentration. Audiometry, electronystagmography with ice water, and vestibular evoked myogenic potentials were performed in all patients. Outcome measurements: VEMPs response and vertigo control.
Ten patients were included; 9 patients with Ménière’s disease and 1 patient with delayed endolymphatic hydrops. Nine patients showed an absent response on VEMPs. The only patient with low amplitude on VEMPs had vertigo recurrence. Vertigo control was achieved in 90% of the patients. One patient developed hearing loss >30 dB.
VEMPs confirmed complete vestibular ablation. High-grade vertigo control was due to total vestibular ablation.
Review the prognosis of facial palsy on Ramsay Hunt syndrome after the treatments proposed by different authors, based on a review of the literature.
A search was performed in LILACS, SciELO, and PUBMED databases. The key words used on the search were: prognosis OR evolution AND ramsay-hunt OR herpes zoster oticus AND facial palsy OR facial paralysis.
Studies showed 882 patients with facial palsy secondary to Ramsay Hunt syndrome. Six hundred and twenty one (70.4%) of those patients achieved improvement on the House-Brackmann grade, achieving a grade score of I or II. Among the patients treated only with steroids, 68% got the same results, versus 70.5% of the patients treated with steroids plus antiviral agents. Of patients classified on the House-Brackmann grade as V or VI before treatment, 51.4% improved facial nerve function, achieving I or II on the HB scale. The treatment with methylprednisolone associated with acyclovir showed better results when compared with acyclovir associated with prednisone, prednisolone or hydrocortisone (81.3% versus 69.2%, 61.4% and 76.3%, respectively).
Patients with Ramsay Hunt syndrome may achieve a good rate of facial recovery. The steroid associated with better results was methylprednisolone, and the association of steroids and acyclovir achieved better results than the patients who did not receive the antiviral agent.
This study was conducted to evaluate the outcomes and complications of transcanal excision of exostoses using micro-osteotomes without a post-auricular incision or the use of the drill.
A retrospective chart review of patients undergoing exostoses excision by the senior author from January 2007 to January 2014 was carried out. All patients underwent surgical removal of the exostoses using a 1 or 2 mm micro-osteotome. Patients were followed postoperatively and complications were evaluated.
One-hundred-thirty-eight ears in 106 patients were treated for exostosis. Average age of patients was 43 ± 16 year old. Of these, 99 were males (93%) and 7 were females (7%). A majority of the patients had 90% to 100% obstruction of the ear canal. Complete ear canal healing was seen in 80% of patients by 3 weeks. All but one patient had healed by 6 weeks postoperatively. There were 9 (6.5%) slit tympanic membrane perforations that all healed. One patient had an anterior canal mobilization which required Xeroform packing for 3 weeks for stabilization. There was no postoperative vertigo, facial paresis, conductive/sensorineural hearing loss, soft tissue stenoses, and no skin grafting was required.
A transcanal approach using micro-osteotomes for removing exostoses is feasible. The transcanal approach afforded shorter healing times than the post-auricular approach as reported in the literature. Patients with 100% obstruction can have this procedure performed with no significant increase in morbidity.
(1) Examine whether unilateral round window membrane injection of adeno-associated virus-1 carrying vesicular glutamate transporter-3 (AAV1-VGLUT3) in congenitally deaf VGLUT3 knockout (KO) mice results in bilateral VGLUT3 expression. (2) Quantify hearing recovery in ipsilateral versus contralateral cochleae following VGLUT3 rescue.
Five wild-type (WT) and 7 VGLUT3 rescued KO mice were used; 2 VGLUT3 KO mice served as deaf controls. Postnatal-day 1 (P1)-P3 VGLUT3 KO mice to be rescued underwent left-ear fixed-volume round window injection of AAV1-VGLUT3. On P21-28, auditory brainstem responses (ABRs) were performed to determine bilateral hearing thresholds. Immunofluorescence was used to count inner hair cells (IHCs) expressing VGLUT3.
The 2 VGLUT3 KO mice were completely deaf and showed no IHC expression of VGLUT3. Rescued mice demonstrated VGLUT3 IHC expression in the injected side (85.8 ± 4.6% relative to WT) that was greater than the contralateral side (31.1 ± 22.7% relative to WT;
The cochlea represents an attractive target for gene therapy due to its bony compartmentalization, but the extent of transfection outside the cochlea has yet to be fully studied. Our study suggests that hearing restoration and IHC transfection occurs bilaterally after unilateral injection, although contralateral changes are significantly less. This supports a model of extracochlear viral spread via cerebrospinal fluid and perilymph, and has important potential implications for future implementation of cochlear gene therapy. This preliminary study provides the basis for a larger, future project examining cochlear and brain expression following VGLUT3 rescue.
The tuning fork remains a useful diagnostic tool in modern otolaryngology practice. Two important variables help describe the sound generated by the tuning fork: frequency and amplitude. We sought to determine whether the manner in which a tuning fork is activated affects its vibrational response.
A Polytec OFV-5000 single point laser Doppler vibrometer was used to obtain direct velocity measurements after activation of 256 Hz, 512 Hz, and 1024 Hz tuning forks with several striking methods: striking the parietal bone, striking the pisiform bone, striking a wood table, and striking a metal surface. Each method was tested using three separate subjective intensities: softly, medium force, and significant force. Data were analyzed using the Polytec Vibrometer Software to produce a velocity spectrum and measurements of frequency and velocity amplitude.
The predominant frequency of motion of all tuning forks was their expected fundamental frequency. Additional nonharmonic frequencies were recorded when striking the 256 Hz and the 512 Hz tuning forks against metal or wood. The aberrant frequencies were of lower intensity relative to the fundamental frequency of the tuning fork.
No additional frequencies were seen with activation on the head or pisiform bone or with the 1024 Hz fork using any method. For the 256 Hz and 512 Hz tuning forks, striking a hard surface produced additional and potentially misleading frequencies. As some providers use this test to guide surgical candidacy decisions in stapes surgery, this could have significant impact in clinical decisions.
We propose a novel technique to remove the matrix of cholesteatoma endoscopically after completely filling the mastoid cavity with saline water by perfusion for the appropriate management of labyrinthine fistulas. This “underwater” endoscopic ear surgery (UWEES) technique provides a clear operative field without requiring suction and protects the inner ear from unexpected aeration that may damage its function.
A 3-year-old boy was diagnosed with congenital cholesteatoma in a group medical examination. Once the surgery was scheduled but suspended due to the Great East Japan Earthquake. At the age of 6 years, computed tomography revealed a fistula of the superior semicircular canal and surgery was performed for removal of the cholesteatoma and closure of the fistula. Retroauricular incision was chosen because of the extensive lesion, using an intact canal skin method with soft wall reconstruction. The cholesteatoma was extirpated except for the island lesion of the matrix over the fistula under the operating microscope. Subsequently, saline solution was infused into the mastoid cavity using Endo-Scrub (Medtronic). The island residual matrix was exfoliated underwater endoscopically and closed with bone paste and covered with the fascia.
No particular complication occurred during the surgical procedure or postoperatively.
Saline water perfusion cleared the surgical field and prevented refraction effects in the high-definition endoscope, resulting in a clear surgical field and prevention of deterioration of cochlear function. UWEES is expected to prevent risk to inner ear function in other interventions such as cochlear implantation, stapes surgery, and temporal bone destruction corrective surgery.
Three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging (3D-FLAIR MRI) has been used to detect alterations in the composition of the inner ear fluid. We aimed to investigate an association between the hearing level and the signal intensity of pre- and postcontrast 3D-FLAIR MRI in patients with sudden-onset sensorineural hearing loss (SNHL).
3D-FLAIR MRI was performed in 18 patients with sudden-onset SNHL: 12 patients with mild-to-moderate SNHL (baseline hearing levels, ≤ 60 dB) and 6 patients with severe-to-profound SNHL (baseline hearing levels >60 dB).
High-intensity signals in the inner ear were observed in 2 of 6 patients (33%) with severe-to-profound SNHL but not in those with mild-to-moderate SNHL (
Our results indicate that 3D-FLAIR MRI is not a useful tool for detecting inner ear abnormalities in patients with mild SNHL.
Vitamin C-deficient (VCD) mice develop spontaneous bone fractures and exhibit hearing loss. However, the effects on the micro-architecture of the ossicles and the underlying mechanisms have not been fully understood. In this study, we test the hypothesis that vitamin deficiency impairs osteoblast differentiation and function of the ossicles.
The morphologic characteristics of the ossicles in VCD and wild-type mice were evaluated with a stereoscopic microscope. Micro-structure of the ossicles was analyzed by micro computed tomography (µCT). Osteoblast differentiation was determined by immunostaining of the bone marker gene, osteocalcin. Sound transmission along the ossicular chain was evaluated with laser Doppler vibrometer.
The ossicles in VCD mice demonstrated thinner bone in the manubrium of malleus and stapes footplate. µCT analyses further verified that the bone volume/total volume fraction (BV/TV) was significantly reduced in the stapes footplate (51.5 ± 3.9% vs 61.2 ± 1.5%;
These findings suggest that VCD decreased expression of osteoblast differentiation marker, osteocalcin, and reduced bone volume and of the ossicles without significantly altering sound transmission. These results may indicate that the pathogenesis of VCD-induced hearing loss might be due to a deficiency at the inner ear or auditory neuron level. Further studies are warranted.
(1) Show the possibility of using optical coherence tomography (OCT) to visualize the internal structure of the vestibule and semicircular canals with the bony capsule intact. (2) Study the effect of the decalcification. OCT is a nondestructive imaging modality that uses infrared light as it penetrates turbid biological tissue. Previously, OCT has been successfully used to visualize inside the cochlea in normal and abnormal inner ears.
The OCT system, OCS-1300SS (Thorlabs, Inc, NJ) with a central wavelength of 1300 nm and a theoretical axial resolution of 9 µm, was employed for image acquisition. Normal and Slc26a4 mutant mice were used as experimental animals. Inner ears were isolated and fixed with 4% paraformaldehyde. Samples were scanned before and after decalcification with 10% ethylenediaminetetraacetic acid for 7 days.
The saccular and utricular maculae and membranous semicircular ducts were delineated with OCT before and after decalcification. Image quality and imaging depth was better after the decalcification. Signals from the otolith were well observed before decalcification. Normal and pathologically dilated endolymphatic ducts in the bony canal in the knock-out mice were also visualized.
OCT have the potential to visualize maculae, membranous semicircular ducts, and the endolymphatic duct through the bony capsule. It may also provide new strategy to evaluate the pathology of otolith.
(1) Describe the changing trends in mastoiditis incidence and bacteriology in the pneumococcal conjugate vaccine (PCV) era.
PCV-7 and PCV-13 have been gradually implemented in the Israeli national immunization program in 2009 and 2010, respectively. We retrospectively identified children aged 0-6 years who had middle ear cultures obtained from “severe” acute otitis media (AOM) episodes, defined as AOM requiring tympanocentesis or presenting with spontaneous otorrhea, during the years 2008-2013. Of those, we identified children with acute mastoiditis. Data were extracted for demographic, clinical and microbial information.
Data from 295 eligible AOM episodes reported in 279 children were collected. Of those, 56 children with 57 episodes of acute mastoiditis were identified. Of these 36 were boys (64%) and 37 (66%) were <2 years old. During the pre-PCV and the PCV introduction period (January 2008-November 2010), mastoiditis incidence rate was significantly higher than the post-PCV introduction era (December 2010-December 2013) incidence, 0.23 versus 0.16/“severe” AOM episode, respectively (
Mastoiditis incidence complicating “severe” AOM decreased after the introduction of PCVs, which can be directly attributed to their effectiveness in reducing pneumococcal-related AOM burden and complications.
Usually, the diagnosis of otosclerosis is based on clinical and audiometric findings, and its confirmation requires surgical exploration of the middle ear. More recently, it has been suggested that high-resolution computed tomography of the temporal bone (TTB) could diagnose and classify otosclerosis into fenestra otosclerosis (FO) and retrofenestral or cochlear otosclerosis (RFO). However, there are relatively few studies that relate these tomographic features with clinical and surgical findings. The aims of the study were to: (1) classify otosclerosis patients with preoperative TTB into fenestra or retrofenestral otosclerosis, and (2) compare these image findings with pre- and postoperative auditory thresholds and epidemiological findings.
Retrospective study by reviewing medical records of otosclerosis patients (2006-2011) undergoing estapedostomy in the Clinical Hospital of the University of Chile (tertiary institution), who were evaluated with preoperative TTB and had full audiometric data. Descriptive statistics and
A total of 74 estapedostomies from 56 patients were evaluated. The TTB study had 87% sensitivity for the surgical diagnosis of fenestral otosclerosis. Age and hearing thresholds were significantly lower in patients with tomographic RFO compared to FO otosclerosis (
The TTB is a useful imaging method to classify otosclerosis patients into RFO and FO varieties. In addition, the RFO corresponds to a more aggressive variety of otosclerosis (younger patients and lower auditory thresholds), and thus this method may be used as a prognostic tool.
(1) Compare the rate of head and defects between children conceived via assisted reproductive technology (ART) versus those conceived via natural methods. (2) Determine the risk of congenital head and neck abnormalities associated with ART.
A retrospective chart review was conducted of all patients admitted to the neonatal intensive care unit over 10 years at Children’s Hospital of Minneapolis. The patients were divided into 2 groups: patients who were conceived via ART and patients who were conceived naturally. Each chart was evaluated for 15 different head and neck malformations, 11 of which were included in data analysis due to statistical significance.
There were a total of 14,857 charts examined; 2288 patients were conceived via ART, while 12,569 patients were conceived via natural methods. There were 40 patients born with defects via ART, while there were 681 patients born with defects via natural conception. There were a total of 9039 males and 6637 females. The total occurrence of congenital malformations was higher for patients not conceived with artificial reproduction versus those conceived with artificial reproduction (4.58% vs 0.27%). The odds ratio was 0.31 with a 95% confidence interval (CI) of 0.23 to 0.43,
There appears to be no increased risk of congenital head and neck defects in children conceived via ART versus those conceived via natural methods.
Describe and demonstrate by video the transnasal endoscopic repair of bilateral mixed or bony choanal (BMCA/BBCA) in low-weight newborns using 1.7-mm diameter telescope and a 0.3- to 06-mm diameter fiber-delivered contact diode laser (CDL) at 810-nm wavelength and combined use of Skeeter stapes microdrill.
Prospective study at a tertiary-care pediatric institution of 11 neonates with BMCA or BBCA, aged 3 to 11 days, weighing 1.8 kg to 2.5 kg. A transnasal endoscopic approach with contact diode laser and/or combined use of skeeter microdrill was applied in all children. All patients were stented bilaterally from 4 to 13 weeks. Patients were followed by serial weekly clinical examinations, rigid endoscope examination at stents removal and/or revision surgery, with subsequent revision surgery if needed. Second surgical revision was performed in 5 children, while 1 child required a third procedure. Five children required 1 procedure only. Further postoperative endoscopic examinations were scheduled for 3, 6, 12 months, and then an annual endoscopic examination was performed.
No complication after surgery was encountered, and all children were discharged the second day after surgery. Follow-up time frame ranged from 1 to 10 years. Neither restenosis nor craniofacial growth abnormality was seen.
BMCA/BBCA was successfully repaired using this narrow endoscopic contact combined microdrill/laser approach, with no complications and a reduced need for revision surgery compared with prior reports. This new surgical technique is demonstrated to treat BMCA/BBCA in small birth weight neonates. Further studies are warranted.
(1) Describe the referral rate of hearing loss in well and at-risk neonates as assessed with transient otoacoustic emission (TEOAE) audiometry. (2) Analyze the association between risk factors for hearing loss and TEOAE referrals.
This was a 2-staged cross-sectional evaluation of hearing loss among 386 neonates; 276 well babies without any risk factors and 110 babies with at least 1 risk factor at the University College Hospital, Ibadan. Data were collected from January 2010 to April 2010. Their ears were evaluated for presence of TEOAE with wideband click of 80-microseconds’ duration at 6 frequencies within 1.5-kHz to 4-kHz at 83 dB pe SPL (±3). Results were automatically displayed as pass or refer. Chi-square test and logistic regression were used to determine the association between the risk factors and hearing loss. The level of significance was
The overall referral rate with TEOAE was 8.5%, 5.2% among the at-risk and 3.3% for those not at-risk (
This study demonstrated that the prevalence of congenital hearing loss in newborns is high in our environment and those at-risk have a higher probability of developing hearing loss.
(1) Determine the association of a sleep endoscopy rating scale with pediatric obstructive sleep apnea (OSA) severity. (2) Assess the reliability of this rating scale.
This was a retrospective cohort study of pediatric patients who underwent drug-induced sleep endoscopy (DISE) from January to December 2013 at a tertiary care children’s hospital. DISE recordings were reviewed by 2 blinded senior pediatric otolaryngologists. Severity of obstruction was scored 0, 1, or 2 for no, partial, or complete obstruction at 6 levels: nasal airway, nasopharynx, velum, oropharynx, tongue base, and arytenoids. Ratings at each level were summed for a total score from 0-12. Associations of DISE scores with obstructive apnea-hypopnea index (OAHI) and OSA-18 scores were assessed using linear regression. Interrater and intrarater reliability were calculated using a kappa statistic with linear weighting.
Twenty patients were included (mean age 8.4 ± 5.1 years, 55% obese, mean OAHI 16.5 ± 15.6). Associations between OAHI and DISE scores were strongest for the nasopharynx (beta = 12.3,
Although observed associations did not reach statistical significance, this pilot study suggests clinically important associations between DISE ratings and OSA severity and showed promising interrater and intrarater reliability.
Quantify the incidence rate of tympanoplasty after tympanostomy tube (TT) insertion in children.
This was a retrospective cohort study of healthy children <18 years old using Medicaid Extract Files from 1999 to 2004. All subjects received TTs and had at least 6 months continuous Medicaid eligibility prior to TTs. We followed patients for 2 years after TTs. The Kaplan-Meier procedure was used to estimate time to tympanoplasty.
There were 270,408 children with billing records for TTs, and 141,243 met inclusion criteria with a follow-up time of 217,431 patient-years. Median age at TTs was 1.62 year, with 58.5% placed at <2 years. Subsequent tympanoplasty was performed in 963 (0.68%), with 324 at age 2-4 years. The median age at tympanoplasty was 5.1 years. Median time from TTs to tympanoplasty was 450 days. The incidence rate of tympanoplasty was 44 cases per 10,000 patient-years (95% confidence interval 41 to 47).
Tympanoplasty following TTs is not uncommon. These repairs are commonly performed in preschool children and often within 2 years of TT placement.
(1) Determine the internalization rates of different strains of Group A Streptococcus (GAS). (2) Determine whether statistically different internalization rates occur in patients who receive a tonsillectomy for sleep-disordered breathing/sleep apnea versus chronic/recurrent tonsillitis. (3) Facilitate the development of GAS vaccine
In vitro microbiology/tissue culture study at an academic tertiary referral center. All tonsillectomy specimens (performed for sleep disordered breathing spectrum and recurrent/chronic tonsillitis spectrum) were collected at the authors’ institution from September 2013 to November 2013. Each specimen was swabbed and bacteria cultured and emm typed. Only specimens with GAS were included in the study. The strains were grown in brain heart infusion (BHI) media to an optic density at 600 nm of 0.5. HeLa and nasopharyngeal carcinoma Detroit 562 cells were grown in tissue culture and subsequently infected with individual strains of GAS at a multiplicity of infection (MOI) of 1:10 for 2 hours. Cells were then washed with Dulbecco’s Modified Eagle Media (DMEM) and reincubated with DMEM plus gentamycin. The cells were then lysed, serial dilutions performed, and the lysate plated. Bacteria were counted and percent internalizations were calculated. This was repeated in triplicate for each strain.
Out of 396 eligible patients, 66 strains of GAS have been isolated. Both the Detroit and HeLa cells have been successfully grown in BHI. The bacterial strains have been subcultured. The authors plan on infecting the cells in March 2014 and will have have conclusive results by April 2014.
None provided.
(1) Demonstrate the prevalence rate of delayed-onset hearing loss in the early school-aged population for the academic year 2010-2011 in a single county of southeastern Michigan, and the state at large. (2) Describe the statewide hearing screening program used in the above population.
Audiometric records of the Oakland County Health Department and the Michigan Department of Community Health for children participating in school-based hearing screening during academic year 2010-2011 were identified. Cross-sectional review of school-based hearing screening results of children in kindergarten, first, second, and fourth grades was performed. Failures were identified and audiograms analyzed confirming hearing loss type. In individuals with sensorineural loss, state newborn screening registries were queried to determine those with true delayed-onset. Demographics and degree of hearing loss on these individuals were collected. Prevalence using official state-level enrollment and census data was calculated.
A total of 46,501 children (~83% of grade-based cohort) participated in school-based hearing screening. Of the 1701 children who failed screening pure tone audiometry, 119 were found to have delayed-onset sensorineural or mixed hearing loss. Male predominance was slight (53%), and 46% had bilateral losses. Newborn hearing screening occurred in the first week of life in the majority (85%). A prevalence of 1.7 to 2.1 out of 1000 in Oakland County was calculated. Delayed-onset hearing loss is projected to have affected between 1325 and 1347 children in this grade cohort statewide during the study period.
Delayed-onset hearing loss remains a not infrequent condition. School-aged hearing screening programs offer a valid mechanism to identify children with this condition.
Observe the effect and safety of sinus balloon catheter dilation (SBCD) on the management of chronic rhinosinusitis in children.
Twenty-seven children (8-14 years old) with chronic rhinosinusitis were randomized into 2 groups: 13 cases were carried out SBCD, and 14 cases treated with medication. The effect was assessed by disease-specific questionnaire (20-items sino-nasal outcome test, SNOT-20) and visual analog score (VAS).
At 3- and 6-month follow-up, the scores of SNOT-20 and VAS were significantly decreased compared with baseline in both SBCD group and controls (
SBCD is an effective and minimally invasive method for child chronic rhinosiunusitis
(1) Recognize that percutaneous implant stability in children can be measured using radio frequency analysis (RFA) to generate Implant Stability Quotients (ISQs) and guide sound processor loading. (2) Discuss sound processor loading of the Cochlear BahaÒ (BIA300, BA400) transcutaneous implants at 4-6 weeks in selected children and potential advantages of the transcutaneous ATTRACT implant.
We collected data prospectively on all children undergoing implantable BC implants at surgery and follow up appointments. We aimed to assess implant stability over time in children undergoing 1-stage surgery using RFA measurements and investigate the possible implications for earlier loading following surgery. Our experience and outcomes with the ATTRACT transcutaneous device as part of the controlled market release (3+ cases) will also be reviewed.
Nine children underwent 10 BI300 implants with a mean age of 9 years 4 months. 7 children received the BA400 percutaneous device without soft tissue reduction, with a mean age of 7 years 11 months. Using RFA the mean ISQ at surgery for BI300 implants was 60 and the corresponding unadjusted value for BA400 implants was 50. Changes in ISQs over time are discussed, showing the potential for processor loading at 4-6 weeks.
Greater implant stability has been demonstrated using the BI300 and BA400 implants, which would subsequently enable early Baha loading. The transcutaneous ATTRACT system potentially offers further improvement in cosmesis and skin inflammation and is likely to have greater acceptance in children with microtia and canal atresia and those who would have previously declined Baha.
Highlight the role of facial plastic and reconstructive surgery in the surgical management of pediatric head and neck lesions and assess cosmetic outcomes.
Retrospective case series of 13 pediatric head and neck lesions managed at a tertiary care children’s hospital. The charts of all patients were reviewed for clinical presentation, radiologic findings, surgical technique used for excision and reconstruction, preoperative and postoperative photography, pathology and cosmetic outcomes.
A total of 13 pediatric patients with ages ranging from 18 months to 12 years had adequate documentation for review. There were 4 naso-frontal dermoids, 4 head and neck skin lesions, 3 midface/orbital bony lesions, and 2 parotid/facial soft tissue lesions. Six patients were managed by soft tissue advancement flaps, 2 required complex linear closure and 2 had a surgical exposure achieved with cosmetically placed incisions. Two patients needed a midface degloving approach for exposure, one required medial osteotomies and bone pate for reconstruction and 2 were managed with calvarial bone grafts. At last follow-up cosmetically acceptable outcomes were photographically documented in all 13 patients. This was confirmed by parental satisfaction.
The involvement of facial plastic and reconstructive surgery is an important adjunct in the management of pediatric head and neck lesions. It leads to better cosmetic outcomes that can be documented and confirmed by parental satisfaction.
(1) Describe factors related to frequency-specific hearing outcomes after type I tympanoplasty in pediatric patients. (2) Describe the effect of powered bone drilling on frequency-specific hearing outcomes after type I tympanoplasty.
Retrospective medical chart review (February 2006 to October 2011) of 492 consecutive pediatric otolaryngology patients undergoing type I tympanoplasty for tympanic membrane (TM) perforation of any etiology at a tertiary-care pediatric otolaryngology practice. Data collected included air conduction at 250 to 8000 Hz, speech reception thresholds, bone conduction at 500 to 4000 Hz, and air-bone gap at 500 to 4000 Hz. Demographic data obtained included sex, age, size, mechanism, location of perforation, and operative repair technique, as well as the use of a powered bone drill during surgery.
A downtrend in sensorineural hearing at 2000 and 4000 Hz was noted with the use of a powered drill during surgery, although no significant difference in sensorineural hearing or air-bone gap was detected at 500, 1000, 2000, or 4000 Hz (
No correlation between high-frequency hearing loss and use of a powered drill during type I tympanoplasty was found in this pediatric population. Surgery was found to significantly improve conductive hearing at 200 and 500 Hz. Based on these results, use of a powered bone drill is not contraindicated during type I tympanoplasty.
(1) Analyze associated findings in patients with hemifacial microsomia. (2) Determine if a new classification of hemifacial microsomia is possible.
A retrospective chart of all patients diagnosed with hemifacial microsomia treated at Children’s Hospital of Minnesota. Each chart was reviewed for the presence of facial paralysis, microtia/anotia, aural atresia, mandibular hypoplasia, midface hypoplasia, dermoids, vertebral abnormalities, ocular abnormalities, sensorineural hearing loss, laterality, renal abnormalities, developmental delay, and skin tags.
A total of 75 patients with hemifacial microsomia were included in this study. There were 43 males and 32 females with an average age of 8.51 ± 5.45 years at the time of chart review. Occurrences for each defect were: facial paresis/paralysis (26.7%), microtia/anotia (73.3%), mandibular hypoplasia (72%), midface hypoplasia (57.3%), vertebral deformities (21.3%), ocular abnormalities (24%), dermoids (21.3%), renal abnormalities (12%), SNHL (17.3%), skin tags (42.7%), bilateral and developmental delay (24%). Regression models were used that showed the odds of having a spinal defect are 3.13 (
The number of craniofacial defects, not just type or severity, increase the risk of having extracranial abnormalities in patients with hemifacial microsomia.
(1) Compare the utility of high-speed video (HSV) versus videostroboscopy (VS) in the assessment of children with normal voices and glottic pathologies. (2) Evaluate the ease of assessment of children with HSV.
This study involved a retrospective assessment of 7 children who had previously undergone HSV and VS in the past 5 years. The 14 videos of these 7 patients were then randomized and presented to 4 groups of blinded evaluators: 2 trained laryngologists, 2 speech language pathologists (SLP) with voice training and experience in a voice clinic, 2 pediatric otolaryngologists, and 2 otolaryngology residents. Raters were asked to evaluate the videos using a standardized scoring tool and to complete a questionnaire assessing their opinion of HSV and VS.
Evaluators required more time to complete their assessment of VS (2.95 minutes ± 2.41 minutes) than HSV (2.31 minutes ± 1.92 minutes;
This is the first comparative study between HSV and VS in patients under 18 years of age. HSV permitted faster evaluation than VS with similar diagnostic accuracy between the 2 modalities. However, the evaluators in this study preferred VS to HSV.
Effective treatments for otitis media with effusion (OME) remain elusive as many patients have recurrence. Direct drug delivery to the middle ear has the potential to maximize efficacy, minimize side effects, and provide a sustained release treatment, which is particularly important in the treatment of biofilms. Polymer-based pellets are delivery vehicles for antibiotics and pellet placement in the middle ear is a potential future OME treatment. In vivo testing of these pellets in animal models is necessary prior to human application.
Twenty-four adult guinea pigs were divided into 3 (n = 8) treatment groups: biological controls, surgical controls, polylactic glycolic acid (PLGA) pellets inserted in middle ear. The surgical approach involved submandibular incision, dissection, and following digastric up to the middle ear bulla. Perforating the bulla wall facilitated a 2.5-mm diameter pellet insertion. Auditory brainstem responses (ABRs) were recorded at 0, 1, 2, 4, and 16 weeks at 6 frequencies over 8 to 30 kHz. Analysis was performed using a paired
Mean ABR thresholds across the 3 groups ranged between 42 and 49 dB SPL over 4 weeks. There were statistically significant threshold elevations between 4-10db SPL in the surgical control and pellet groups although these were not considered physiologically significant.
Using a guinea pig model, PLGA pellet insertion into the middle ear caused ABR threshold elevation of only 4-10 dB SPL, supporting their use as a potential vehicle for middle ear drug delivery.
Congenital cytomegalovirus (CMV) is the most common cause of newborn infections in developed countries, affecting up to 1% of newborn babies. Symptomatic CMV can occur in up to 10% of viral positive babies, including manifestations ranging from sensorineural hearing loss, microcephaly, developmental delays, and others. The aim of the study was to evaluate the incidence of congenital CMV in a general population of newborn babies.
Institutional review board approval was obtained. Newborn blood spots were obtained. The blood spots were evaluated using quantitative real time polymerase chain reaction (PCR) for CMV. The PCR primers and probes were purchased from Life Technologies and based on the sequences published by Schovoerer et al. A CMV standard curve was generated for each PCR run with a human cytomegalovirus (AD169) and a quantitated viral DNA PCR control (Advanced Biotechnologies, Inc). The DNA was serially diluted to obtain a quantitative curve.
Six hundred blood spots were analyzed: 50% were male; 50% were Caucasian; 50% were African American. One female African American baby was found to have CMV.
Our local data suggest a smaller incidence of CMV than the general population. The study is a small study and the implications are unclear. Further study is needed.
(1) Report our experience in children with sudden-onset sensorineural hearing loss (SSNHL). (2) Describe the etiology and management of children with SSNHL.
Retrospective review of 20 children with SSNHL, from 2000-2013 at a tertiary pediatric facility. Patients had the following inclusion criteria: history of normal hearing, hearing loss occurring in less than 3 days, and audiogram documentation.
The average age of patients presenting with SSNHL was 11 years 2 months (22 months-18 years). Only 6 (30%) presented prior to 2 weeks. Tinnitus (55%) was the most common associated symptom, followed by otalgia (25%), and vertigo (20%). Eight patients had bilateral hearing loss, 6 only right and 6 only left. Hearing loss severity ranged from profound (45%) being most common to mild. Etiology was unknown (30%), viral (30%), due to an anatomic abnormality (20%), endolymphatic hydrops (10%), autoimmune (5%), perilymphatic fistula (5%), and suppurative labyrinthitis (5%). Eight patients had initial treatment with oral steroids of which 50% had improvement on audiograms. Two patients underwent intratympanic injections, and both showed improvement. Of the 12 patients with no treatment, only 1 had improved hearing.
The true incidence of SSNHL is unknown. Younger children may be unable to express hearing loss. Unique aspects of pediatric SSNHL are delayed presentation and higher percent of anatomic findings. In our study, 70% presented more than 2 weeks after experiencing symptoms. Anatomic abnormalities are in 20% of patients. Hearing improvement occurred in 50% of children treated with oral steroids. Intratympanic steroid treatment is another option but may have practical limitation in the pediatric population.
(1) Analyze the data of our series of cases of infantile hemangiomas (IH). (2) Describe the clinical characteristics and contemporary treatment modalities of the disease to general and pediatric otorhinolaryngologists.
The medical records of children diagnosed with airway hemangiomas at Hacettepe University Hospital, Department of Otolaryngology between 2005 and 2013 were reviewed retrospectively. The study included 17 patients with IH of the airway. Four patients (23.5%) were male and 13 (76.5%) were female. All of the patients received medical treatment. Six patients (35%) did not respond to medical treatment and surgical intervention was needed. Five in the surgical group required tracheotomy.
All patients with tracheotomies were decanulated and stridor in all of them either disappeared or significantly improved. Endoscopic examinations of all of the patients revealed an open and safe lumen. After beginning propranalol as the medical agent, only one patient needed surgical intervention. None of the patients had any major complications.
Medical treatment with propranalol of subglottic hemangioma is the first line choice. If medical treatment options fail, surgical intervention should be considered. Overall purpose should be the patient’s airway safety.
(1) Describe the Connecticut Airway Risk Evaluation (CARE) system, an airway grading system describing the risk of a patient’s airway above the tracheotomy tube. The CARE was designed to improve handoffs between caregivers for tracheotomized patients. (2) Analyze the reliability of teaching and ease of learning the CARE system for otolaryngologists.
The CARE system is a simple, easy to use scale that divides patients into the following groups: 1, easily intubatable; 2, intubatable with specialized techniques or equipment; or 3, not intubatable. A brief tutorial was designed to introduce the system and was presented to a group of otolaryngologists. A 30-point questionnaire was administered in which patients’ airways and airway management techniques were described, and the participant was asked to grade each example according to the CARE system.
Fifteen participants completed the study, including 9 attending physicians and 6 resident physicians. Overall interrater reliability was calculated for all participants with a 90.3% agreement (Kappa = 0.837). Attending physicians had a 86.1% agreement (Kappa = 0.766). Resident physicians showed 98.9% agreement (Kappa = 0.981).
The CARE system is a reliable method of classifying airway risks in the event of an airway emergency in a tracheotomized patient. We have shown that the CARE system can be easily taught to otolaryngologists with high interrater reliability. The CARE system may help simplify handoffs between caregivers while emphasizing the important aspects of a patient’s airway. Adequate implementation of the CARE system may improve the understanding of airway management options in complex tracheotomized patients.
(1) Validate a low-fidelity mannequin model engineered to teach drainage of peritonsillar abscesses. (2) Pilot this mannequin model in instructing incoming otolaryngology residents on drainage of peritonsillar abscesses.
A peritonsillar abscess (PTA) simulator was constructed through modification of the Laerdal MegaCode Kid Mannequin head using inexpensive components. Tonsils were constructed from Dermasol, and the peritonsillar abscess was simulated by placing a balloon filled with a mixture of water and body lotion behind the appropriate soft palate region. A feedback electrode was placed behind this to create an audible buzz if the needle went too far, simulating entrance into the carotid artery. The model was validated by a panel of experts through survey, and subsequently used to teach PTA drainage to PGY2 otolaryngology residents.
The expert panel unanimously agreed that they would use the device to teach PTA drainage to trainees. The model was then used to instruct a novice group (N = 6). The majority of this novice group reported that the session was a vital part of their training experience, and it was important to practice drainage of a PTA on a mannequin.
We validated a mannequin task trainer for drainage of peritonsillar abscesses and successfully implemented it into a teaching session. Given the frequency of presentation of PTA, the need to become competent in the procedure early in residency, and the success demonstrated using our model, we believe the model could be inexpensively replicated at other institutions for more safely and effectively teaching the procedure.
(1) Understand the importance of an interdisciplinary approach to the selection of patients with Pierre Robin sequence for mandibular distraction osteogenesis. (2) Recognize that unfavorable outcomes can be linked to inaccurate preoperative assessment.
A retrospective review of 10 consecutive patients with Pierre Robin sequence who underwent mandibular distraction from July 2011 to July 2013 at Children’s Memorial Hermann Hospital was performed. Age at distraction, associated syndromes and medical conditions, pre- and postoperative sleep studies, and complications were evaluated. Follow-up ranged from 6 months to 2 years.
A total of 10 patients with Pierre Robin sequence underwent mandibular distraction. Two had defined syndromal diagnoses and two had undefined chromosomal abnormalities. Average pre and postoperative AHI were 31.5 and 4.5, respectively. Average distraction length was 24 mm. Eight of the 10 patients who underwent distraction had successful outcomes defined by relief of obstructive apnea, reduction in AHl, and improved feeding at 2 months. Two patients had unfavorable outcomes. One did not respond to the distraction procedure and had a delayed diagnosis of spinal muscular atrophy, ultimately resulting in death. The other patient had multiple congenital anomalies and failed to respond to the distraction. The patient had significant laryngomalacia on post distraction repeat L and B, required tracheostomy, and later died of cardiac shunt failure.
In the properly selected patient, mandibular distraction in patients with Pierre Robin sequence can be successful. Preoperative assessment involves both art and science, but ultimately determines the success or failure of the distraction procedure.
Compare the growth of infants with moderate to severe laryngomalacia who underwent supraglottoplasty to the growth of those treated with medical therapy alone.
Retrospective case-control chart review of patients treated between 2008 and 2013 in a tertiary care pediatric otolaryngology practice. 51 infants newly diagnosed with moderate to severe congenital laryngomalacia were included. A total of 17 infants underwent supraglottoplasty and 34 matched controls had medical management, which included acid suppression therapy, speech and swallowing therapy, and/or high-calorie formula. The primary outcome measure was weight percentile recorded at the second clinic visit and at the last available follow-up. The secondary outcomes were the need for tracheostomy or gastrostromy, development or persistence of failure to thrive, surgical complications, and new onset developmental delay. The management strategy was considered a success if none of the secondary outcomes occurred.
There was no difference in the mean weight percentile between the surgical and nonsurgical groups at the time of last follow-up (
Medical management and close observation of infants with moderate to severe congenital laryngomalacia may be a viable alternative to supraglottoplasty.
(1) Examine the current trends in neonatal tracheostomies and compare them to historic cohorts. (2) Determine and stratify the current risk factors for failed extubation in the neonatal intensive care unit (NICU).
We conducted a retrospective review of 34 consecutive neonatal tracheostomies performed over a 5-year period (2008-2012) in a university-based tertiary care hospital. Risk factors for failed extubation were identified and analyzed.
Sixty-two percent of the infants had identifiable anatomic causes of airway obstruction, whereas the remaining (38%) had significant isolated pulmonary disease (
Neonatal tracheostomies are currently being performed for anatomic airway abnormalities more frequently than primary pulmonary disease as previously documented. It suggests that current respiratory therapies have lowered the burden of chronic lung disease. Even as more low-birth-weight neonates are being rescued, the presence of multiple concurrent risk factors did not appear to increase the chances of extubation failure or need for tracheostomy within this population.
(1) Examine the birth prevalence of macroglossia, assessing for differences across sex, race, socioeconomic status, and geographic location. (2) Identify comorbidities associated with isolated and syndromic forms of macroglossia and determine how such factors may influence length of stay (LOS) and cost of admission.
Retrospective cross-sectional study using the 2006 and 2009 Kids’ Inpatient Databases (KID).
The national birth prevalence of macroglossia was 3.4 out of 10,000 births (n = 556) with a higher rate in females (3.9/10,000,
The birth prevalence of macroglossia varies by sex, race, and geographic location. Prolonged LOS and increased cost are associated with syndromic forms of macroglossia. Syndromic comorbidities rather than enlargement of the tongue in and of itself appear to be the chief contributors to increased LOS and cost in this population.
(1) Identify the current public health burden of pediatric temporal bone fractures. (2) Determine if the introduction of bicycle helmet and child safety seat laws has resulted in a change in national patterns.
The 2000 and 2009 Kids’ Inpatient Databases were used to gather data on a sample of all pediatric discharges in the United States during the years 2000 and 2009. Children diagnosed with basilar skull fractures were identified by corresponding ICD-9 codes. Database analyses generated national estimates of summary statistics and comparison of trends over the 9-year period.
The estimated prevalence of pediatric skull base fractures requiring hospitalization in the United States has remained essentially stable with 9641 (95% confidence interval [CI]: 8782, 10,501) admissions in 2000 and 10,581 (95% CI: 9532, 11,630) in 2009. Likewise, the mean age is unchanged from 10.02 (95% CI: 9.66, 10.38) years to 9.76 (95% CI: 9.44, 10.07). The proportion of female patients is the same (33%) (95% CI: 0.031, 0.34) and (95% CI: 0.0.32, 0.35) respectively. Total charges increased from $25,900,000 (95% CI: $22,200,000, $29,600,000) to $60,300,000 (95% CI: $53,100,000, $67,600,000) with a mean charge per admission increasing from $28,958 (95% CI: $26,302, $31,615) in 2000 to $57,596 (95% CI: $53,134, $62,058) in 2009. The mean length of stay remained stable at 6.04 (95% CI: 5.60, 6.48) to 5.31 (95% CI: 5.00, 5.62) hospital days.
The public health impact of pediatric skull base fractures continues to be substantial. Despite the institution of bicycle helmet and child safety seat laws, national trends demonstrate a stable prevalence of hospital admissions, age at admission, sex distribution, and mean hospital stays with an increasing economic burden over the past decade.
(1) Describe a novel technique for repair of type I laryngeal clefts. (2) Review the current literature on various techniques for repair of type I laryngeal clefts.
A retrospective review of patients under 18 years with a type I laryngeal cleft who underwent endoscopic laryngeal cleft repair (LCR) by a single surgeon at a tertiary care otolaryngology specialty hospital using a successful novel technique from July 1, 2013, to February 14, 2014, was conducted. This technique uses electrocautery to demucosalize the cleft on a setting of 6, followed by repair of the cleft with 2 endoscopically placed sutures. Charts were assessed for age at surgery, comorbidities, diet, length of stay, complications, and outcomes.
Eleven patients were identified, with an average age of 28 months (range, 9-68 months). Eight of 11 (73%) of patients were restricted to nectar thick-diet preoperatively, 2 out of 11 (19%) to honey thick-diet, and 1 out of 11 (9%) to half-strength honey thick-diet. Postoperative swallow results were available for 7 patients. Five of 7 patients demonstrated clinical or radiographic evidence of resolution of aspiration. One had improvement of aspiration but persistent penetration, and another had continued aspiration and is being evaluated for a neurologic disorder.
Although type I laryngeal clefts have traditionally been endoscopically addressed using either a cold technique or a laser to demucosalize the cleft, our technique offers an advantage over cold knife by providing improved hemostasis and broader demucosalization. In addition, when compared with the laser technique, it offers similar broad demucosalization without deeper thermal damage.
Adenoidal hypertrophy (AH) is the most common cause of pathologic mouth breathing in children. Medical treatment of adenoid hypertrophy includes treatment of allergies, nasal sprays, and antibiotics. However, in some cases AH continues to produce symptoms despite maximal medical therapy. Potential risks of anesthesia and complications of surgical procedures have led to the promotion of non-surgical alternatives. During the past 3 years, advances in expertise and technology led to the new advent of using office based setting for nonsurgical procedures by the author as an innovative method for treatment of AH.
Sixty five children who were definitive candidates for surgical adenoidectomy were managed with radiofrequency treatment under endoscopy control without any need of general anesthesia. The age range was between 4 and 15. All children underwent direct endoscopic examination of adenoid before and after procedure.
The period of follow-up was from 2 to 32 months. Patients experienced different degrees of improvement after nonsurgical procedure, according to a researcher-based questionnaire. The results were impressive for some parents because of marked improvement by very simple procedure as compared to surgery.
Nonsurgical radiofrequency reduction of adenoid size has multiple advantages: excellent magnified view of adenoid area, accurate reduction of central obstructing part of adenoid, nonbleeding, evaluation and treatment of other nonadenoid obstructing problems, complete preservation of normal nasopharyngeal structures, no general anesthesia, no operating room stress, no hospitalization, high safety, no complications, and better patient tolerance using this fast and easy procedure.
(1) Analyze the difference between prescribed doses and manufacturer recommended doses of acetaminophen and ibuprofen for pediatric otolaryngology patients in the postoperative setting. (2) Highlight a problem with manufacturer dosing advice for over-the-counter analgesics.
We selected 53 consecutive children who had otolaryngology operations requiring general anesthesia in 2013. These children were discharged with instructions to use over-the-counter analgesia, as per current departmental practice. We compared the manufacturer recommended doses of generic over-the-counter acetaminophen and ibuprofen with doses of the same analgesics that they would have had as inpatients during the postoperative period.
Manufacturers often recommend a range of doses. With acetaminophen, even when assuming the highest recommended doses were used, we found that children would have received on average 16% less acetaminophen than they would have had in hospital. (
Over-the-counter acetaminophen and ibuprofen come with dosing advice guided by age. Our analysis demonstrated that this could often be substantially different from the ideal dose, which is based on the child’s weight. With the global trend of increasing body weight, we can expect this disparity to get bigger in the future. Good pain management is important in pediatric otolaryngology, but this result is relevant to all clinicians caring for children.
Obstructive sleep apnea (OSA) has been hypothesized to be protective against postoperative tonsillectomy hemorrhage, presumably due to the upregulation of prothrombotic factors. This study investigates this possible correlation in patients at our institution.
A 6-year retrospective case control study of tonsillectomy only and adenotonsillectomy cases done on children up to 16 years of age, from the end of January 2007 through the end of January 2013. The number of postoperative bleeds that required return to the operating room for hemostasis were recorded.
There were 2320 tonsillectomy cases. A total of 1581 were adenotonsillectomies and 730 were bilateral tonsillectomies only. Thirty-four cases returned to the operating room for hemostasis. Overall postoperative hemostasis rate was 1.47%. A total of 450 cases were listed as recurrent tonsillitis, 383 listed as OSA (confirmed on polysomnography [PSG]), and 1487 listed as adenotonsillar hypertrophy (no PSG done, presumed OSA). Of the 34 cases that returned to theatre, 9 were OSA cases, 8 were recurrent tonsillitis, and 17 were for hypertrophied tonsils (presumed OSA), giving a postoperative hemostasis rate of 1.39% for the OSA patients and 1.78% for recurrent tonsillitis.
Despite the possible upregulation of prothrombotic factors in OSA, we found no real difference in postoperative tonsillectomy hemostasis rate in our patients, contrary to findings in other studies.
(1) Describe current prescribing practices and opinions of membership of the American Society of Pediatric Otolaryngologists (ASPO) regarding analgesia after pediatric adenotonsillectomy. (2) Understand prevailing opinions about opioids and nonsteroidal anti-inflammatory drugs (NSAIDs) that influence medication selection in this setting.
Pain management after pediatric adenotonsillectomy is controversial. We conducted a web-based survey of ASPO membership to understand current post-adenotonsillectomy prescribing practices, with emphasis on attitudes regarding opioids and NSAIDs.
A total of 110 responses were received. Seventy-eight percent of respondents indicated that they sometimes or always prescribe an opioid as first line analgesic. A majority (74%) indicated they frequently prescribe NSAIDs, while 11% indicated they avoid them entirely. A total of 76% agreed or strongly agreed that opioids increase risk of respiratory events after tonsillectomy, versus 19% in regard to NSAIDs increasing risk of post-tonsillectomy hemorrhage. More than 10 years in practice was associated with increased concern that NSAIDs increase bleeding risk (24% vs 4%,
Significant heterogeneity exists among pediatric otolaryngologists regarding optimal pain management after adenotonsillectomy. Most respondents indicated they frequently prescribe opioids, though most expressed concern about respiratory suppression. We also found broad support for NSAID use among respondents, with comparatively few expressing concern regarding bleeding risk.
(1) Describe the most prevalent findings of anamnesis and physical otolaryngologic examination in patients with mucopolysaccharidoses (MPSs), which are a lysosomal storage disorder group caused by deficiency of enzymes involved in catabolism of glycosaminoglycans. (2) Evaluate the importance of a multidisciplinary approach for MPSs patients.
A descriptive cross-sectional (prevalence) study performed in January 2014. Thirty-four MPSs patients followed at a tertiary teaching hospital were invited, from which 25 participated from the study, with agreement of their families. Questionnaires were answered by their parents and a physical examination was done. The analyzed variables were otologic, pharyngolaryngeal, and nasal and respiratory signs and symptoms.
Among the evaluated patients, 52% (13/25) were male and 48% (12/25) female. The average age was 12.44 years at examination and 5.14 years at MPS diagnosis. The most frequent subtype was MPS VI (12/25). Hearing complaints were present in 60% (15/25) of patients, snoring in 44% (11/25), with witnessed sleep breathing pauses in 24% (6/25). The number of pharyngotonsillitis and upper airway infections was 1.68 and 3.36 episodes in the past year, respectively. Important findings on physical examination were: hyperplastic gums (60%-15/25), modified Mallampati score IV (64%-16/25), tonsil size grade III (60%-16/25), flattened nasal pyramid (80%-20/25), and tympanic retraction (24%-6/25).
There is a high prevalence of ear, nose, and throat manifestations that requires further investigation and possibly intervention, such as suspected respiratory sleep disturbances and hearing loss. There was a similar prevalence of respiratory tract infections as expected for age. Results support recommendation for multidisciplinary approach.
Review a single institution’s experience with parotidectomy in pediatric patients.
A retrospective chart review was performed on children undergoing parotidectomy between 1994 and 2013. Data included presenting symptoms, tumor histology, postoperative complications, facial nerve weakness, and disease recurrence.
Forty-two pediatric patients underwent parotidectomy. Preoperatively, 16 patients (38%) presented with an asymptomatic mass, 7 (17%) had pain, 18 (43%) had recurrent infection, and 6 (14%) had skin involvement. Surgical pathology revealed 20 (48%) infectious or inflammatory lesions, 15 (36%) benign lesions, and 7 (17%) malignant lesions. The infectious and inflammatory lesions included granulomatous infections (26%), hyperplastic lymphadenopathy (12%), and chronic sialadenitis (10%). Lymphangioma (14%) and pleomorphic adenoma (12%) were the most common benign lesions. Malignant lesions included one (2.4%) of each of the following: acinic cell carcinoma, adenoid cystic carcinoma, mucoepidermoid carcinoma, melanoma, scute lymphoblastic leukemia, Hodgkins lymphoma, and Langerhans histiocytosis. The patient with adenoid cystic carcinoma had recurrence of disease, and required a second extirpative surgery. Facial weakness occurred in 19 (45%) patients. Of these, 9 (47%) had infectious or inflammatory lesions. Permanent weakness occurred in 5 (12%) patients. The facial nerve was intentionally resected in one patient (recurrent adenoid cystic carcinoma); the other 4 had surgery for infectious or inflammatory lesions. Additional complications included facial pain (3 patients), wound infection, seroma, and Frey syndrome (one each).
Short-term facial paresis is common in pediatric parotidectomy, especially when surgery is for infectious or inflammatory disease. Parotid neoplasms are uncommon and malignancies are especially rare.
Analyze surgical treatment modalities for pediatric laryngotracheal stenosis.
We retrospectively reviewed patients that underwent laryngotracheal surgery for stenosis between 2002 and 2012. Age, sex, etiologic factors, stenosis grades, comorbidities, surgical techniques, decannulation rates, and complications were evaluated. There were subglottic stenosis (SGS), posterior glottis stenosis (PGS), and tracheal stenosis (TS). Surgical details and outcomes were examined for endolaryngeal procedures, laryngotracheal reconstruction (LTR), partial cricotracheal resection (PCTR), and tracheal resection (TR).
There were 44 patients. Prolonged intubation because of trauma was the leading primary cause of stenosis. Congenital stenosis and congenital heart disease operations were also present frequently. There were 20 LTRs, 13 endolaryngeal balloon dilatation, 7 PCTRs, and 4 TRs. Decannulation was successfully accomplished in 27 of 32 patients (84%). Overall success rate in airway management was 91% (40/44). Restenosis was observed after 8 LTRs and 2 PCTRs. Major complications were bilateral recurrent nerve paralysis, postoperative death due to sepsis, and accidental extubation with an overall rate of 6% (3/44).
Pediatric airway surgery needs good multidisciplinary cooperation. Correct indication and precise surgical technique are important factors in determining the results. Endolaryngeal procedures should be performed only for membranous and/or low grade stenosis cases, otherwise they cause more tissue damage, leading to fibrosis that complicates the pathology. LTR with anterior and/or posterior grafting is suitable for grade II and III stenosis, while PCTR should be the first choice of treatment for grade IV stenosis. Open surgical procedures should be performed as a single stage surgery if possible.
(1) Determine perinatal medical factors associated with auditory neuropathy spectrum disorder (ANSD). (2) Compare risk factors associated with ANSD to those in sensorineural hearing loss (SNHL).
Retrospective case-control study of children diagnosed with ANSD at an academic tertiary care center between July 2009 and January 2014. Inclusion criteria for the ANSD group were normal otoacoustic emissions, absent or elevated middle-ear muscle reflexes, and severely abnormal or absent auditory brainstem response waveforms. The ANSD group was compared with 2 age- and sex-matched control groups: (1) normal-hearing children and (2) children with SNHL.
Twenty-two patients (15 male, 7 female) met ANSD inclusion criteria, and were matched to 2 control groups as described above. Case and control groups were assessed for the following perinatal risk factors: prematurity, low birth weight, hyperbilirubinemia, mechanical ventilation, and administration of ototoxic antibiotics. On multivariate logistic regression between ANSD and normal-hearing groups, hyperbilirubinemia (
ANSD, a clinical spectrum of disease united by normal cochlear function but abnormal auditory pathway transduction, remains an enigmatic entity. In the present study, matched comparisons between ANSD versus normal-hearing and SNHL control groups identified perinatal hyperbilirubinemia and ototoxic antibiotics as significant risk factors. Diligent hearing evaluation to diagnose ANSD in infancy, particularly among patients with a perinatal history of hyperbilirubinemia, is critical.
There is substantial information regarding environmental and clinical risk factors for otitis media in young children; however, limited data exist in 6- to 12-year-old patients and specifically those in which surgical intervention is performed. This study investigated potential risk factors for de novo or refractory otitis media in this older age group who required pressure equalization tube (PET) insertion.
A retrospective study was performed at a tertiary care academic hospital for children 6 to 12 years old undergoing PET insertion between October 1, 2010, and September 30, 2011. The data were stratified into 2 separate age cohorts (6-7 versus 8-to 12-year-olds) for analysis.
A total of 263 patients met the inclusion criteria. PET insertion was more common in the 6-year-old age group (36%, 95/263), which decreased by age with a negative relationship. No significant sex-based difference was observed. Presence of siblings (
The older cohort (ages 8-12 years old) had more infectious symptoms including otalgia, otorrhea, and nasal discharge than the younger cohort (ages 6-7 years old). In contrast, history of RAOM, allergy, asthma, and atopy were not significantly different between these age groups. Overall, this study provides further understanding of pertinent risk factors in older children requiring new or recurrent PET insertion.
This cross-sectional study compared dental occlusion in 56 children (29 males and 27 females) between 5 and 7 years of age (mean of 5.8 years) enrolled in an ongoing, longitudinal study designed to characterize the changes in Eustachian tube (ET) anatomy and function between 3 and 8 years of age. Subjects with cleft palate, other syndromes predisposing to otitis media (OM), cholesteatoma, or past/current orthodontic treatment were excluded. Dental casts were made between 5 and 7 years of age and selected measurements on the casts from 29 children with a confirmed history of recurrent acute otitis media (rAOM) that required placement of ventilation tubes were compared to those from 27 children with no past history of middle ear disease.
The measurements included overbite (%), overjet (mm) and mandibular second primary molar crown height (mm) made using a calibrated perioprobe and occlusal relationships referenced to the first molar were assigned. A discriminant function analysis identified average crown height (Avg CH) only as a predictor of group assignment and this was confirmed using a general linear model where Avg CH controlled for age was significantly higher in the control group (
The results support those for a previously published study that reported a lesser vertical dimension of occlusion to characterize children with ET dysfunction and ME disease.
Investigate the applicability of 3DMIA software to upper airway modeling in children with obstructive sleep apnea hypopnea syndrome (OSAHS).
A total of 12 children diagnosed with OSAHS by polysomnography were included in this study. Data regarding upper airway structure were collected via spiral computed tomography (CT) while sleeping and awake, from which a 3-dimensional model of the upper respiratory tract from the nasopharynx to the supraglottic region using 3DMIA software was constructed. The upper airway volume and airway minimum cross-sectional area were measured employing software algorithms.
The upper airway volume and airway minimum cross-sectional area of the 12 children during sleep were significantly less than while awake (
3DMIA software modeling and software algorithm measurement were more objective than traditional radiology with respect to evaluation of the extent of the upper airway narrowing in OSAHS children, and showed good applicability to studying upper airway morphology and function in children with OSAHS.
The technique of transoral infant laryngoscopy was described a decade ago, but has not gained wide acceptance. We present a 10-year experience with the method as an alternative to transnasal examination in newborns and edentulous infants, focusing on practicality, safety, and quality of examination.
We queried a prospectively accrued database of 22,000 office examinations to identify all transoral flexible laryngoscopy examinations performed from 2001 to 2011 by the senior author. Records were reviewed for patient age, indication for laryngoscopy, diagnoses, and adverse events.
One hundred forty infants, aged 2 days to 10 months, were evaluated. Fifty-seven patients were female and 83 were male. Stridor was the most common indication for laryngoscopy (90.7%) and 89 (63.6%) patients were diagnosed with laryngomalacia. The larynx was well seen in 99.3% of examinations. There were no episodes of airway obstruction or bleeding. Two children experienced emesis (1.4%).
Transoral flexible laryngoscopy is a safe method for examining the infant larynx. It permits rapid, comfortable examination using a conventional-sized office fiberscope in most infants prior to dental eruption. It avoids the need for topical anesthesia, vasoconstrictors, sedation, or general anesthesia for most children. Office examination is not advised for infants with severe upper airway obstruction.
Investigate the role of cochlear microphonics (CM) that could be simultaneously acquired in auditory brain stem response (ABR) test in neonatal hearing screening.
From April 2013 to January 2014, hearing screening tests were performed on 51 newborns treated in neonate intensive care unit. The subjects underwent transient evoked otoacoustic emission (TEOAE) and auditory brain stem response (ABR). The amplitude of CM was acquired by applying 90 dB-click sound of condensating and rarefacting polarity.
There were 68 ears with normal results in ABR, CM and OAE. Auditory neuropathy was suspected in 2 ears that had presence of CM and OAE with abnormal ABR waveform. Amplitude of CM correlated with reproducibility of OAE (p<.01) inversely correlated with latencies of wave I and III (
Amplitude of CM had correlation with results of OAE and ABR test. CM might provide more stable information about cochlear hair cell than OAE test which could be easily influenced by condition of middle ear or external ear. We suggest CM as a useful supplementary tool for OAE test.
Sleep-disordered breathing (SDB) affects approximately 12% of children, ranging from snoring to obstructive sleep apnea (OSA). Polysomnography (PSG) is the gold standard for diagnosing SDB and has been increasingly obtained in children. Some feel PSG is underutilized given recent clinical guidelines; however, others believe that if the clinical indicators for OSA are present, a PSG is unnecessary. The purpose of this study was to determine the effectiveness of clinical indicators in predicting PSG results in children.
A retrospective review of PSG on children between 2 and 18 years old ordered by an otolaryngologist at West Virginia University between January 2011 and November 2013. Recorded variables included: age, sex, symptoms of gasping, snoring, restlessness, body mass index, previous adenoidectomy, tonsil size, and apnea-hypopnea index (AHI). Statistical analysis was used to compare positive PSG with clinical indicators.
Ninety-five patients were reviewed with 73 meeting inclusion criteria. Age range was 2 to 17 years (mean, 5.3 years) and mean AHI was 3.26. Gasping showed a statistical significant correlation with positive PSG (61.9% positive,
Gasping is an effective clinical indicator in predicting positive PSG and diagnosing OSA in children.
Compare success and complication rates of primary tracheocutaneous fistula closure compared with fistulectomy with secondary fistula healing.
A systematic literature search was performed on PubMed. All prospective and retrospective studies of tracheocutaneous fistula (TCF) closure techniques in pediatric patients were included for initial analysis. The authors’ unpublished cohort of 13 fistulectomy patients was also included in the overall analysis. Primary outcomes were surgical success rate and major complication rate. Fisher exact test was used for statistical analysis.
Thirteen studies were identified for inclusion in the systematic review; 8 studies reported both success rates and complications. The total number of patients in all included studies was 259 (median, 19; range, 8-98). Techniques included fistulectomy with multilayer closure (197), primary closure alone (2), and fistulectomy alone with healing by secondary intention (60). Success rates were comparable between fistulectomy alone (95.0%) and primary closure techniques (97.5%) (
While both primary closure techniques and secondary healing techniques for pediatric TCF closure have excellent success rates, fistulectomy with healing by secondary intent is associated with less reported major complications.
Congenital absent oval window is an uncommon condition that results in significant conductive hearing loss in the pediatric population. Treatment outcomes and results following surgery are still not well established in light of the limited cases that have been published in the literature. This study aims to evaluate the outcomes following surgical intervention of patients with congenital absent oval window in a single institution.
This is a retrospective review of patients who underwent surgical exploration and treatment for congenital absent oval window from 2000 to 2013 in a single institution.
Twelve patients were diagnosed with congenital absent oval window. Six of these patients were affected bilaterally. Of the 19 ears affected, 13 were operated on. Eight ears were successfully treated following stapedotomy and insertion of prosthesis. The average pure-tone audiogram for these patients was 62.6 prior to the operation. Following surgery, the average pure-tone level was 22.4. Five of the ears that were operated on showed minimal improvement. Of these 5 ears, 3 were unsuitable for insertion of prosthesis due to unfavorable position of the incus. Two patients underwent stapedotomy with Teflon wire prosthesis insertion. However, this failed to improve hearing levels.
Congenital absence of oval window is an uncommon condition that can lead to significant disruption to hearing. Surgical intervention by means of stapedotomy and prosthesis insertion may lead to significant improvement in hearing levels selected patients. However, it may be technically unsuitable for others.
Otitis media with effusion (OME) is established to be universally present in children with cleft palate. It is found to be most prevalent during the age of 4 to 6 years. This problem may continue to recur in this group of patients, seeming to settle during adolescence. The aim of this retrospective study was to examine OME in cleft palate pediatric patients, with or without cleft lip, and determine the average number of ventilation tube insertions required for this group of patients from birth to 16 years of age.
This retrospective study reviewed 258 pediatric patients who have undergone cleft palate repair and myringotomy with ventilation tube insertions in KKWCH during the period from 1990 to 2012. Information to be collated included: type of cleft, when repair of the cleft was performed, when ventilation tubes were inserted, and how many ventilation tube insertion procedures were performed.
The period of follow-up ranged from 2 to 13 years. The ratio of boys to girls was 1.3 to 1. It was found that a large percentage of patients between 2 years to 13 years of age had 3 or less sets of ventilation tube insertions. The youngest to have received tube insertion was 7 weeks old. The oldest was 14 years old.
OME in cleft palate patients may be a recurrent problem. Knowing the likely progression of the disease is useful when counseling the parents involved.
Exome sequencing (ES) is a single platform test that screens the exons of nearly all genes and is increasingly being used in the clinical diagnosis of hearing loss due to the large number of genes etiologically implicated. Our goals were to explore (1) the utility and limitations of ES for diagnosis in children with sensorineural hearing loss (SNHL) and (2) its ability to discover novel genes causing SNHL.
Thirty-six children with bilateral SNHL underwent ES: 26 without an etiology for their SNHL after standard clinical testing, and a control group of 10 with known mutations. Exome variants were initially filtered using a list of 264 genes associated with hearing loss.
In the 10 children with known mutations, all were correctly identified by ES except 3 large deletions. Analysis of the 26 unknown samples found likely pathogenic mutations in 8 (31%). A definitive diagnosis was obtained in 1 additional child, who had an unusual MITF mutation that led to the diagnosis of Waardenburg syndrome. In one other family, a novel candidate gene was identified which previously has never been implicated in human disease. Affected children in that family had profound SNHL accompanied by malformation of the vestibular labyrinth. Mutations in this gene segregated as expected among the 8 family members.
ES is a powerful tool for both diagnosis and discovery for genetically heterogeneous conditions like SNHL. Despite limitations inherent to using gene lists and only sequencing exons, this technology has great promise for helping ascertain the etiology of SNHL in children.
(1) Appreciate the current diagnostic limitations and significant misinterpretation rate (nearly 50%) of acute otitis media (AOM) and otitis media with effusion (OME) by general practitioners and pediatricians using the conventional otoscope. (2) Recognize the optical properties of middle ear effusion (MEE) and this innovation’s ability to improve diagnosis using a concentrated (laser) light.
Laser otoscopes were developed and designed with class IIIa lasers. The laser propagates with the incandescent light to illuminate on the tympanic membrane (TM). An institutional review board–approved prospective pilot study was completed at a tertiary care hospital. Study patients were 1 to 18 years and undergoing ear tube placement. The laser otoscope was used on each ear for assessment of MEE prior to myringotomy. The simple objective presence or nonpresence of a glow of the laser on the TM surface was recorded. Presence of a glow signified MEE due to the dispersion quality of light through liquid versus air. True presence of MEE was then determined with myringotomy.
Fifty ears (25 patients) were enrolled. Assessing only for a simple objective glow without any further interpretation of the middle ear contents yielded an 89.4% accuracy for determining MEE.
The laser otoscope is a novel, simple, and potentially extremely useful tool for assisting in otoscopic determination of fluid in the middle ear. Particularly among primary care givers, MEE assessment may be able to be increased from nearly 50% to nearly 90%, by simply assessing for a laser glow or no-glow on the TM surface.
Nasal packing is commonly used to control postoperative bleeding in patients undergoing inferior turbinate surgery. During packing removal, patients usually undergo severe pain and bleeding. The objective of this study was to investigate the efficacy and safety of glove finger-coated polyvinyl acetate (PA) pack on hemostasis, pain levels, and wound healing after partial inferior turbinectomy.
A prospective, randomized, double-blinded controlled study was conducted on 30 patients undergoing partial bilateral inferior turbinectomy using microdebrider for hypertrophic rhinitis. Fifteen patients (control group) had both nasal cavities packed with PA pack (Merocel; Medtronic Xomed, Jacksonville, FL) and another 15 subjects (experimental group) had their nasal cavities packed with PA in a glove finger. Pain levels were assessed by patients on a visual analog scale 12 hours after surgery and at the time of packing removal. The amount of bleeding on removal was quantified by weighing it after removal.
Both nasal packs effectively prevented postoperative bleeding. However, bleeding on packing removal was statistically less frequent and less severe with PA pack in a glove finger (
PA packing in a glove finger is a recommendable method in terms of pain, bleeding on packing removal, compared with PA pack only.
Immunologic reactions to antigens released by Aspergillus fumigatus can cause infections such as allergic bronchopulmonary aspergillosis (ABPA). The mucosal surface of the respiratory tract provides host defense mechanism. The aim of this study was to investigate whether respiratory epithelial cells recognize A. fumigatus extract (AE) and initiate an immune response. We report inhibition of Th1 biased epithelial inflammation by an Aspergillus extract.
BEAS-2B epithelial cells were cultured in a 37°C incubator in media supplemented with 5% FBS. Cells were treated in duplicate with AE for 1 hour and were stimulated with the TLR3 activator dsRNA for 6 hours. RNA was isolated and was reverse transcribed to cDNA. Realtime polymerase chain reaction analysis was performed in the presence of specific primers and fluorescently labeled probes.
IFN-β and dsRNA both induced IP-10 mRNA expression in BEAS-2B cells (IFN-β 1081-fold; n = 3;
We found that AE inhibits the IP-10 mRNA and protein secretion in bronchial epithelial cells.
(1) Describe the first reported case in otolaryngology literature of a patient with Crouzon syndrome with late cerebrospinal fluid (CSF) rhinorrhea and encephalocele formation after prior Le Fort III facial advancement surgery. (2) Review the literature pertaining to the incidence and management of this complication in craniofacial dysostoses (CD). (3) Analyze issues surrounding repair of these complications, including occult elevations in intracranial pressure (ICP), the use of perioperative CSF shunts, and the importance of considering alternative repair schemes.
Literature review of studies describing CSF rhinorrhea and encephalocele formation following facial advancement in CD, focusing on management strategies.
CSF rhinorrhea and encephalocele formation are rare complications of craniofacial advancement procedures. Occult elevations in ICP complicate the prospect of permanent surgical repair, necessitating the use of transcranial repair and CSF shunts in addition to the now more common endoscopic approach. Though no consensus exists regarding the use of perioperative CSF drains, strong associations exist between elevated ICP and failed surgical repair. Additionally, the anatomic changes in the frontal and ethmoid sinuses after facial advancement present a challenge to endoscopic management.
Otolaryngologists should be aware of the possibility of occult elevations in ICP as well as sinonasal anatomic abnormalities when repairing CSF rhinorrhea in patients with CD. Clinicians should consider CSF shunt placement and carefully weigh the advantages of the open, transcranial approach versus endonasal, endoscopic techniques.
Ciclesonide is an intranasal corticosteroid for the treatment of allergic rhinitis. To date, concrete evidence to justify a definitive recommendation of intranasal corticosteroid over oral antihistamine has not been demonstrated. This study aimed to evaluate the efficacy and safety of once-daily ciclesonide in comparison to both levocetirizine alone, and a ciclesonide/levocetirizine combination in patients with seasonal (SAR) and perennial AR (PAR).
Subjects exhibiting moderate to severe allergic rhinitis for longer than 1 year were randomized in an open-label, 3-arm, parallel group, multicenter study. Subjects received 200 µg ciclesonide, 5 mg levocetirizine, or a combination of both. Changes from baseline until the end-of-study visit (2 weeks following) were evaluated by reflective total nasal symptom scores (rTNSS), reflective total ocular symptom scores (rTOSS), physician-assessed overall nasal signs and symptoms severity (PANS), and rhinoconjunctivitis quality-of-life questionnaires (RQLQ).
Significant improvements in rTNSS, PANS, and RQLQ in the ciclesonide monotherapy group were observed in comparison to the levocetirizine alone group. Three individual symptoms of rTNSS were improved in the ciclesonide-treated group. rTOSS scores for ciclesonide monotherapy improved from baseline, but no superiority over levocetirizine was shown. Ciclesonide spray was more effective than levocetirizine in reducing nasal symptoms in both SAR and PAR patients. Ciclesonide and levocetrizine were well tolerated alone and in combination.
Our results provide support for an AR and its Impact on Asthma (ARIA) recommendation stipulating that ciclesonide is superior to levocetirizine for the treatment of AR, with tolerable safety. Addition of levocetirizine to ciclesonide did not give further clinical benefit over monotherapy.
Investigate the histopathological effects of fat grafting harvested from lipoaspirate adipose tissue on atrophic rhinitis in an animal model.
An animal model of atrophic rhinitis was obtained by application of pasturella multocida toxin diluted with 0.9% NaCl into nasal cavities for 3 weeks. Eleven Wistar Hanover rats were included in this study and divided into 2 groups. The study group was composed of one side of nasal cavity with atrophic rhinitis. The fat grafting harvested from lipoaspirate adipose tissue was applied into nasal cavity submucosally. After 2 weeks of follow-up, rats were decapitated and nasal cavities were resected totally. A histopathological examination was done.
There was a significant improvement in the study group compared with other groups according to basal membrane degeneration and glandular atrophy. The vacuolar degeneration, squamous metaplasia, keratinization, vascular proliferation, inflammatory infiltration, and congestion were not significantly different between groups.
Our study showed that fat grafting harvested from lipoaspirate adipose tissue has a positive healing effect over degenerated mucosa on atrophic rhinitis, in addition to the volume enhancer effect of tissue itself. The adipose tissue may normalize the volume of large nasal cavities caused by atrophic rhinitis. In addition, histopathological disorders of atrophic rhinitis, such as glandular atrophy and basal membrane degeneration, are reversed significantly.
Chronic rhinosinusitis with nasal polyp is a clinically common disease, and cigarette smoking is a major risk factor for airway inflammation. However, little is known about the effects of smoking on eosinophilic rhinosinusitis (ERS) with nasal polyp. A histopathologic and molecular study was performed to investigate the effects of smoking using mouse model of ERS with nasal polyp.
Mice were divided into 4 groups: control group, smoking group, ERS group, and ERS + smoking group (N = 8, each). Histopathologic changes were investigated using several special stainings: Hemotoxylin and eosin for overall inflammation and polyp-like lesions, Sirius red for eosinophils, Toluidine blue for mast cells, Alcian blue for secretory goblet cells, and Masson’s trichrome for collagen fiber. Serum IgE levels and systemic cytokines were determined using enzyme-linked immunosorbent assay. The expression of vascular endothelial growth factor (VEGF) and HIF-1a were evaluated by immunohistochemical staining.
Smoking enhanced the degree of polyp-like lesions, eosinophil infiltrations, goblet cell deposition, and subepithelial fibrosis in ERS model. Total and OVA-specific IgE levels were increased in both ERS groups, however, smoking had no additive effect on them. The systemic cytokines (IL-4, IL-6, IL-17, and IFN-γ) were also elevated significantly by smoking. Smoking enhanced VEGF expression in nasal epithelial cells, suggesting underlying mechanism of increased polyp formation.
Smoking exposure had additive effects on experimental ERS. It resulted from increased local and systemic inflammation, and airway remodeling. Increased VEGF might be its underlying mechanism.
Evaluate and compare nasal symptom scores and quality of life (QOL) findings in allergic rhinitis patients.
A total of 426 adult allergic rhinitis patients’ medical records were evaluated retrospectively. Group A consisted of 188 patients and received mometasone furoate nasal spray (100 mcg daily/nostril). Group B consisted of 238 patients receiving cetirizine (10 mg oral/daily) for 30 days. Nasal symptoms (watery discharge from the nose, nasal congestion, sneezing and nasal pruritus) and QOL (Short Form-36) were recorded before and after treatment.
When compared before and after treatment, each group’s total nasal symptom scores reduced significantly (Group A,
Although intranasal mometasone furoate is a better choice than oral cetirizine, both of these medicines can be used to control allergic rhinitis symptoms and improve patient QOL.
(1) Describe a totally endoscopic-assisted technique for septoplasty. (2) Assess the outcomes of endoscopic-assisted technique according to subjective and objective criteria. (3) Compare the outcomes of the endoscopic-assisted approach with those obtained with the traditional headlight technique.
This prospective, randomized, controlled trial was conducted from September 2010 to September 2013 at the ENT University Unit of the A. Fiorini Hospital, Sapienza University of Rome. A total of 160 patients undergoing surgery for septal deviation meeting strict inclusion/exclusion criteria were recruited. Patients were randomly assigned to either the endoscopic (Group A) or the conventional group (Group B). Endoscopic evaluation and anterior rhinomanometry were carried out pre- and postoperatively. Nasal Obstruction Symptom Evaluation (NOSE) scale was used to measure the nasal obstruction before and after surgery. At the end of each procedure the junior residents compiled a 10 cm visual analog scale (VAS) which evaluated their overall understanding of the surgical procedure. Surgical times and complications were recorded.
All patients showed a significant improvement of nasal obstruction (
The endoscopic approach represents a viable alternative to traditional headlight septoplasty. Furthermore, endoscopic-assisted septoplasty may be considered to be better than the traditional approach in a teaching perspective.
Based on the close relationship between histamine and IL-6, we hypothesized that histamine plays a role in the production of cytokines such as IL-6 and is involved in the microenvironmental controls of the allergic inflammatory process. We describe in nasal fibroblasts the effect of histamine on the production of IL-6, the major histamine receptors, and the related underlying mechanisms.
Nasal fibroblasts from eight normal patients were incubated. Reverse transcriptase polymerase chain reaction was performed for histamine receptors (H1R, H2R, H3R, and H4R) to identify which histamine receptor is expressed in nasal fibroblasts. The fibroblasts were treated with histamine with or without a histamine-receptor antagonist, and IL-6 production was measured using ELISA. Three MAP kinases (p38, ERK, and JNK) and NF-κB were evaluated as downstream signaling molecules by Western blot analysis and Luciferase reporter assay.
Expression levels of all histamine receptors were elevated. The level of IL-6 protein expression increased significantly with histamine stimulation. Among the histamine-receptor specific antagonists, only H1R antagonist significantly decreased IL-6 production in histamine-stimulated nasal fibroblasts. Histamine increased the level of phosphorylated p38 (pp38), pERK, pJNK expression, and NF-κB induction. H1R antagonist reversed the increased expression of pp38 and NF-κB in histamine-induced nasal fibroblasts, but not pERK and pJNK. p38 inhibitor markedly suppressed the increased production of IL-6 in histamine-stimulated nasal fibroblasts.
The results of the present study suggest that antihistamines could be involved in the regulation of cytokines such as IL-6, beyond the blockage of the histamine effect as an inflammatory mediator in nasal fibroblasts.
Voice is a person’s main communication tool and affected by many factors, including the upper respiratory tract. The upper respiratory tract influences mainly resonation, and the nose is one of the key points. Seasonal allergic rhinitis may affect voice quality via changing resonation. This study aims to evaluate the possible changes on voice caused by seasonal allergic rhinitis subjectively.
Between October 15, 2013, and January 15, 2014, 28 patients who applied to our out-patient clinic and diagnosed with seasonal allergic rhinitis were included in the study. Mean age of the patients was 28.4 and all were female. Patients were asked to complete voice handicap index 30. Control group was composed of 30 female patients who did not have seasonal allergic rhinitis. Values were analyzed in statistically nonpaired samples using Student
The mean voice handicap index score was 16.4 in the study group and 5.5 in the control group. There was a statistically significant difference between the 2 groups (
Seasonal allergic rhinitis has an adverse affect on vocal quality, subjectively.
Sublingual immunotherapy (SLIT) has recently received much attention around the world as a treatment of allergic rhinitis (AR). However, some patients experience early adverse events (EAE) during SLIT. This study aimed to investigate the predisposing conditions of EAE and the influence of EAE on treatment outcomes in the house dust mite (HDM) SLIT for AR.
As a retrospective cohort study, 226 patients diagnosed with AR and sensitized to HDM started HDM-SLIT in 2010. The symptomatic improvement was measured by a total nasal symptom score (TNSS) before and 6 months after SLIT. EAE were divided into 3 categories, local and systemic EAE and aggravation of nasal symptoms. The TNSS in the 3 groups of EAE were compared. The medical records and diaries of 125 patients were reviewed.
TNSS decreased from 9.7 to 3.9 six months after SLIT. There were 28 patients (22.4%) who experienced EAE. TNSS was improved in both non-EAE and EAE groups 6 months after SLIT, and there was no difference in the 6-month changes of TNSS between the non-EAE and EAE groups. Significant improvement of TNSS was found in local EAE or early aggravation of the symptoms. The rescue medication score in the group of local EAE stayed relatively low both 1 month and 6 months after SLIT.
Even though HDM-SLIT sometimes caused EAE, it did not affect SLIT. The cumbersome local EAE in SLIT was self-limited and neither gave an adverse influence to the symptomatic improvement nor elevated the frequency of the rescue medication.
Fibroblast migration is crucial for normal wound repair after sinonasal surgery. Prostaglandin E2 (PGE2) is a potent inhibitor of fibroblast functions including chemotaxis, proliferation, and matrix production. The purpose of this study was to determine whether PGE2 affects the migration of nasal fibroblasts and to investigate the mechanism of action of PGE2 on nasal fibroblasts.
Primary cultures of nasal fibroblasts were established from inferior turbinate samples. Fibroblast migration was evaluated with scratch assays. Reverse transcription-polymerase chain reaction was performed for E-prostanoid (EP)1, EP2, EP3 and EP4 receptors. EP receptor-selective agonists and antagonists were used to evaluate receptor functions. Stimulatory G (Gs) proteins were activated to evaluate mechanisms. Intracellular cyclic adenosine monophosphate (cAMP) levels were measured by enzyme-linked immunosorbent assay, and fibroblast cytoskeletal structures were visualized with immunocytochemistry.
PGE2 significantly reduced the migration of nasal fibroblasts. Agonists selective for the EP2 and EP4 receptors significantly reduced the nasal fibroblast migration. Antagonists of the EP2 and EP4 receptors inhibited the effect of PGE2 on nasal fibroblast migration. Activation of Gs protein and adenyl cyclase reduced nasal fibroblast migration.
PGE2 inhibited the migration of nasal fibroblasts via the EP2 and EP4 receptors, and this inhibition was mediated by cAMP elevation. Targeting specific EP receptors could offer therapeutic opportunities for conditions such as delayed wound healing after nasal surgery.
Many pro-inflammatory cytokines are regulated by acetylation and deacetylation of core histone. Since dysregulation of Th2 cytokine production is a key for the pathogenesis of allergic diseases, we examined the role of histone deacetylase (HDAC) on expression of IL-4 gene in mast cells. We also examined whether oxidative stress has some impact on HDAC activity.
RBL-2H3 cells, a rat mast cell line, were sensitized overnight with DNP-specific IgE. The cells were then treated with HDAC inhibitors (trichostatin A) for 15 min and stimulated with DNP-antigen. After 2 hour incubation, total RNA was isolated to determine the level of IL-4 gene transcription by real-time reverse transcriptase polymerase chain reaction (Taqman system). After incubated with H2O2 for 0 to 24 hours, HDAC activity was measured in nuclear extracts obtained from the RBL-2H3 cells with HDAC Fluorescent activity assay kit (BIOMOL) as well as the detection of IL-4 mRNA.
IL-4 mRNA expression was induced with antigen in IgE-sensitized RBL-2H3 cells. Pretreatment of trichostatin A and H2O2 enhanced IL-4 mRNA expression with dose-dependent manner. There is 5-fold induction of IL-4 mRNA by HDAC inhibitors. HDAC activity of RBL-2H3 cells were reduced with H2O2 treatment.
Our results suggest that oxidative stress may up-regulate IL-4 gene expression in mast cell via decrease of HDAC activity.
This study investigated the role of human papillomavirus (HPV) in malignant transformation of paranasal inverted papilloma (IP).
HPV presence and viral load and physical status of HPV-16 were examined by polymerase chain reaction-based methods using fresh frozen samples or paraffin-embedded samples obtained from 17 patients with IP (IP group), 5 with IP and squamous cell carcinoma (IP+SCC group), 16 with SCC (SCC group), and 67 with chronic inflammatory lesions (inflammatory group).
The presence of the HPV genome was detected in 29.4%, 40.0%, 25.0%, and 6.0% of patients in the IP, IP+SCC, SCC, and inflammatory groups, respectively. The IP group showed significantly higher HPV-positive rates than the inflammatory group. All types of HPV detected were high-risk HPV, especially HPV-16. The relative HPV-16 copy numbers varied from 2.5 to 7953 per 50 ng genomic DNA. Viral load was higher in the IP+SCC group than in the inflammatory group. In the IP group, no significant relationship was found between HPV-16 viral load and clinical characteristics. All patients with IP+SCC and SCC showed integration of HPV-16.
High viral load and integration of HPV have an important role in malignant lesion in association with IP.
Chronic rhinosinusitis with nasal polyposis (CRSwNP) is characterized by B cell inflammation. We sought to determine whether immunoglobulin class switch recombination (CSR) occurred locally within polyps and to quantify the expression of proteins involved in regulating CSR. Germline transcripts (GLTs) are produced during CSR, and activation-induced cytidine deaminase (AICD) is an enzyme that is required for CSR. Thus, GLT and AICD expression can be used as markers for CSR.
Polyp (n = 12-37), tonsil (n = 7), and uncinate tissue (UT) from patients with CRSwNP (n = 9), CRSsNP (n = 10), and normal controls (n = 11-12) were collected. Quantitative reverse transcriptase polymerase chain reaction for GAPDH, GUSB (housekeeping genes), AICD, IL-15, iNOS, BAFF, and A1, A2, G1, G4, and E GLT was performed using cDNA from tissue. Relative expression was calculated in relation to a housekeeping gene.
AICD expression was significantly increased in tonsils compared with all other groups (
These results suggest that local CSR is occurring in polyps of patients with CRSwNP.
Chronic rhinosinusitis (CRS) is a chronic inflammatory disease involving the mucosa of the nasal cavity and sinuses. It can be classified into CRS with nasal polyps (CRSwNP) and without nasal polyps (CRSsNP). It is often described as a chronic inflammatory condition of the sinonasal mucosa and followed by a continuous tissue remodeling process. The CXC chemokine such as CXCL1 and CXCL8 are primarily chemotactic for endothelial cells and neutrophils, whch are potent promoters of angiogensis and inflammation.
In this study, we examined the effects of kinin on CXC chemokine expression in human nasal fibroblasts from mucosa specimens of patients with CRSsNP.
We found kinin increased CXCL1 and CXCL8 release in a concentration- and time-dependent manner, as determined by enzyme-linked immunosorbent assay. In parallel, reverse transcriptase polymerase chain reaction analysis showed the kinin increased CXCL1 and CXCL8 mRNA level, suggesting this process involved transcriptional regulation. The increased CXCL chemokines appeared to have chemoattractive ability toward monocyte. We found monocyte migration increased as monocytes and fibroblasts were cocultured and the fibroblasts were stimulated with kinin in an indirect transwell co-culture system.
Our results suggest that kinin may play a role in causing chemokine release and recruit leukocytes infiltration in the nasal inflammation microenvironment during chronic rhinosinusitis.
Inverted papillomas are benign sinonasal tumors arising from Schneiderian mucosa. The inverted papillomas represent 0.5% to 4% of all sinonasal tumors. The purpose of this review was to analyze the patients with inverted papilloma treated in Hospital Prof. Doutor Fernando Fonseca, Portugal.
A retrospective review was performed of patients with inverted papilloma over a 10-year period.
The authors found 12 cases of inverted papilloma, mean age of 63 years old with male predominance. In collaboration with the neuroradiology department, the authors found 1 case in Stage I, 4 cases in stage II, 5 cases in stage III, and 2 cases in stage IV of Krouse’s Staging System. The endoscopic surgical approach was used in 11 cases (combined with external approach in 7 cases) and isolated external approach in 1 case. The meantime of follow-up was 28 months. There was recurrence in 4 cases and 1 had malignant transformation.
The treatment of inverted papilloma is surgical, with the endoscopic approach the choice in the majority of the cases. A follow-up for a long period is necessary. A larger number of cases for analysis would be necessary to confirm the review’s results.
The aim of this study is to depict changes in the nasal mucosa by studying transmission and scanning electron microscopic pictures.
This study was performed on 50 consecutive patients from the Department of Otolaryngology at Tanta University, Egypt between October 2008 and January 2013. Patients were candidates for total laryngectomy for advanced laryngeal cancer. Each patient was subjected to a biopsy from the nasal mucosa 1 cm behind the anterior end of the inferior turbinate using Blakseley forceps. Specimens were subjected to scanning as well as transmission electron microscopic examination.
All patients after total laryngectomy demonstrated at least 1 histopathologic abnormality. Focal or total atrophy in the nasal mucosal epithelium was found. The epithelial cells showed vacuolation, loss of cilia, and few short microvilli, as well as separation of epithelial cells with loss of junctional complexes. Widening of the binter-cellular spaces as well as focal disruption of the basement membrane, clear separation of epithelial cells from each other were also noted in some patients. In some patients marked thickening of basement membrane and angiogenesis of the lamina propria were seen. An increase in the number of active fibroblasts with increased collagen deposition, and swelling and degeneration of mitochondria was also evident.
Changes in the nasal mucosa after total laryngectomy would eventually result in lack of mucus synthesis and consequently, inadequate mucus secretion, and could disturb the mucociliary transport
Chronic rhinosinusitis (CRS) is one of the most common causes of olfactory dysfunction. After endoscopic sinus surgery (ESS), olfactory function may improve in most cases, but may not in others. The purpose of this study was to investigate the prognostic factors for olfaction improvement after endoscopic sinus surgery in CRS.
A total of 103 patients (175 nostrils) with CRS who underwent ESS were studied. We performed olfactory function test for all patients using the butanol threshold test (BTT) and Cross Cultural Smell Identification test (CC-SIT) preoperatively and postoperatively. The patients’ subjective symptoms were also recorded using the visual analog scale (VAS) pre- and postoperatively. We also analyzed the duration of disease and preoperative computed tomography by Lund-Mackay score.
The improvement of olfactory function after ESS in patients with longer duration of symptoms was not significantly lower than in patients with shorter duration. In multivariable study, anosmics had better improvement than hyposmics in recovery of olfaction. There were significant differences in anterior ethmoid involvement between responder and non-responder group.
The improvement of olfaction after ESS mainly depends on the degree of preoperative olfactory function and involvement of anterior ethmoid involvement. Therefore, for the better outcome of ESS especially in olfactory function, early and proper treatment (including ESS) for CRS will be necessary.
(1) Analyze the safety of using Propel mesh implant in revision sinus surgery. (2) Analyze the efficacy of maintaining a medial position of the middle turbinate without synechiae in the postoperative period.
This was a retrospective study between July 2012 and February 2014 in 16 patients with chronic rhinosinusitis undergoing revision sinus surgery and who underwent placement of a Propel mometasone implant into the ethmoid bowl at end of the procedure. Placement of the Propel was unilateral in some or bilateral in others. Surgery was conducted at outpatient surgical centers. Safety measures included incidence of bleeding, orbital migration of mesh, and chronic scabbing. Efficacy measures included incidence of synechiae and maintenance of medial position of the middle turbinate.
A total of 26 Propel implants were placed. The incidence of complications from the implant was zero and the efficacy of maintaining a medialized middle turbinate without synechiae was 100%.
In selected patients with chronic rhinosinusitis undergoing revision sinus surgery, the placement of a Propel mometasone implant into the ethmoid bowl is safe and effective at maintaining a medialized position of the middle turbinate without synechiae formation.
Nasopharyngeal carcinoma (NPC) local recurrence still represents a major clinical challenge and a high mortality and morbidity cause. The authors report a case of a 44-year-old male with clivus osteoradionecrosis (ORN) and dural radionecrosis who presented with cerebrospinal fluid (CSF) leak, 6 months after a boost of stereotactic radiosurgery using gamma knife for the treatment of locally recurrent NPC, following conventional external beam radiotherapy (EBRT) with chemotherapy.
A direct transnasal endoscopic-assisted approach with multiple reconstructive pedicled flap technique was used to achieve watertight dural reconstruction.
Despite CSF leak recurrence, after the second attempt we achieved a successful clivus reconstruction using a bilateral posterior pedicle inferior turbinate flap (PPITF). The reconstruction withstood a watertight seal for 1 month, until patient death from cardiopulmonary arrest as a result of ventilator-associated pneumonia.
We recommend an early diagnosis and surgical intervention in the setting of clivus ORN. Local debridement of necrotic bone is critical for local nasal graft adherence and survival. The evidence of dural radionecrosis is a predictor of bad prognosis. As a result, broad dural defect exposition should be the standard procedure with the use of a multi-layered technique combined with vascularized pedicle flaps regardless of the dural tear dimension.
(1) Describe the clinical caracteristics of postviral anosmia, comparing with anosmia related to chronic rhinosinusitis (CRS). (2) Analyze its response to corticosteroid treatment.
A retrospective study was performed on 66 patients with olfactory loss. Olfactory function was assessed at baseline using the Connecticut Chemosensorial Clinical Research Center test. Clinical records were reviewed to discharge CRS, post-traumatic and other certain etiologies. Computed tomography and magnetic resonance imaging were reviewed. Topical, oral corticosteroids, or both were used on postviral cases for at least 6 months.
Patients were evaluated after 6 and 12 months of follow-up. The mean age at diagnosis was 53.8 (standard deviation 12.92). There were 74.2% females (49/66) and 25.8% males. The most frequent etiology was postviral anosmia, 51.5% of cases (34/66). At the time of diagnosis, the mean combined olfactometry (threshold test + identification test/2) was 2.75 (standard deviation 2.36). After 12 months, the mean was 4.70 (standard deviation 3.21), a significant improvement compared to baseline. No significant differences between the improvement obtained with topical corticosteroid therapy and/or oral were found. No differences were found comparing to treatment response of anosmia related to CRS.
Postviral anosmia occurs most often in women. Olfactory recovery is uncommon, and topical or systemic corticosteroids were similarly ineffective.
Immunoglobulin (Ig) G4-related disease has been widely known to affect many organs including the lacrimal gland, salivary gland, pancreas, retroperitoneal, etc. There are a few reports concerning the nasal lesion of this disease. However, the difference between the nasal manifestation of IgG4-related disease and allergic rhinitis (AR) has not been clarified. We compared the pathological findings in nasal specimens of IgG4-related disease with those of allergic rhinitis.
Nasal mucosa was obtained from patients with IgG4-related disease and AR. We examined the infiltration of IgG4 positive cells and other infiltrating cells. These infiltrating cells in IgG4-related disease group were compared with those in the AR group. We also assessed the number of nasal glands in IgG4-related disease and the AR group.
The number of IgG4-positive plasma cells was significantly higher in the IgG4-related disease group than that in the AR group. CD3 and CD4 positive cells were also significantly higher in the IgG4-related disease group than in the AR group. The number of nasal glands was decreased in the IgG4-related disease group less than the AR group.
The number of IgG4, CD3, and CD4 positive cells was significantly higher in the IgG4-related disease group than that in the AR group. There is a possibility that the nasal manifestations of IgG4-related disease might be different from AR.
(1) Describe the presence of a skull base cerebrospinal fluid (CSF) leak that occurred in a patient after receiving radiation therapy for a residual pituitary adenoma. (2) Analyze possible factors contributing to this rare occurrence.
Case report with a retrospective chart review.
A 49-year-old African American female received 23.4 Gy in 13 fractions of definitive external beam radiotherapy for a residual nonfunctioning pituitary adenoma involving the left parasellar area for 16 days prior to developing a CSF leak. Cisternogram demonstrated a small focus of dehiscence in the right tuberculum sella, measuring 1.5 mm in diameter with a small amount of contrast present anterior to this dehiscence. This also demonstrated fluid in the right lateral aspect of the sphenoid sinus in communication with the intracranial CSF. CSF leak may occur after radiation as a tumor shrinks and leaves defects in the skull base and dura at the tumor site. Interestingly, the CSF leak in this patient occurred at a different location than that of the pituitary tumor. This suggests that radiation may weaken the skull base at sites other than tumor sites.
CSF leak is known to occur after skull base surgery, but has not previously been reported after radiation in regions of the skull base away from previous sites of surgical manipulation. This case report identifies a middle skull base CSF leak in a post-radiation patient.
Evaluate the effectiveness and biocompability of propylene mesh in an animal model of nasal septal perforations on rabbits.
A nasal septal perforation model was created on rabbits, then nasal septal perforations were closed via 2 different methods with open rhinoplasty technique. Some perforations were closed with mucosal flaps and propylene mesh as interpositional graft. The others were repaired with bilateral mucosal flaps. After 4 weeks, nasal septums were totally removed and histopathological evaluation was done for acute rejection, infection, inflammatory response, fibrosis, and granuloma formation.
No septal perforation was repaired in the mucosal flap-only group. In the second group, all perforations were repaired completely. Of 5 samples of study group, 1 showed +1 (62.5%) inflammatory response, 1 (12.5%) sample showed +2 and 2 samples showed +3 (25%), respectively. A total of 3 (37.5 %) samples of group 2 did not show any fibrosis, 4 (50%) samples showed mild fibrosis, and 1 (12.5%) sample showed moderate fibrosis. A total of 7 (87.5%) samples showed mild fibrosis at most. We did not see any severe fibrosis at all. We observed 6 (75%) samples that showed no granuloma formation as foreign body reaction and 2 (25%) samples showed few giant cells. Heavy vascular and epithelial proliferation was seen along borders of propylene mesh.
Propylene mesh showed good biocompability with septal mucosa and can be used for repair of septal perforation as interpositional graft safely.
Postsurgical stenosis of frontal sinus can be a challenging problem for the endoscopic sinus surgeon. Frontal sinus stents are often used in an attempt to maintain frontal outflow patency. The current study systematically reviews the literature to determine the safety and efficacy of frontal stents.
The Pubmed, Google Scholar, and Cochrane databases were reviewed and studies evaluating the usage and reliability of frontal sinus stents were extracted based on defined inclusion criteria.
Eleven studies comprising a total of 192 patients met inclusion criteria and were evaluated for stent material, stenting duration, surgical techniques, patient outcomes, and complication. All studies were classified as level 4 evidence provided by the Oxford Center for Evidence Based Medicine. Multiple stent materials were used with varying duration. Complications were generally minor and included stent migration, pain, epistaxis, and infection. Frontal sinus patency following stent replacement varied from 71.4% to 100%, however, the efficacy of stent placement in maintaining frontal sinus patency could not be evaluated due to a lack of controlled studies.
Current literature evaluating the use of frontal sinus stents is limited and comprised entirely of level 4 studies. The efficacy of frontal sinus stenting could not be accurately evaluated because of the small number of studies and variable outcome measures. Larger, high-quality studies are needed to support the use of stents in endoscopic surgery of frontal sinus.
Although allergic fungal rhinosinusitis (AFRS) is a well-recognized entity, few data are published concerning the prevalence of mold sensitization in patients with polypoid chronic rhinosinusitis (PCRS). Our aim was to determine the prevalence of fungal and common aeroallergen sensitization in a sample of adult patients with PCRS at an ear, nose, and throat clinical setting.
All adult patients with PCRS who underwent sinus surgery between September 2012 and December 2013 were invited to participate. Prick tests were done with
Sixty-three patients were included (60% men), mean age (SD) 45 (15.4) years old. Of the patients, 14.3% had at least 1 positive skin prick test for molds (9.5% for Aa, 4.8% for Ch, 6.3% for Af, 4.8% for Cl and 4.8% for Fm). Forty-percent were allergic to dust mite and 27% to pollen. We failed to detect an association between fungal sensitization and age (
Almost one-sixth of our patients were mold sensitized. The routine determination of fungal allergic profile may improve the assessment of patients with PCRS, increasing awareness to AFRS diagnosis.
IL-5-induced chemotaxis of eosinophils is an important feature for atopic diseases. Lipid lowering agents, statins, have been shown with inhibitory ability for inflammatory process and leukocyte accumulation. We herein investigate their effects on chemotaxis of eosinophils and the possible regulating mechanisms.
Eosinophils were derived by treating HL-60 clone 15 (HC15) with butyric acid in an alkaline condition. The 2 most potent chemokine and cytokine receptors for eosinophils, CC-chemokine receptor-3 (CCR3) and IL-5 receptor (IL5R), were verified on the cell line. Dose effect of IL-5 stimulation for chemotactic ability toward eotaxin and CCR3 presentation was measured. Simvastatin effect for IL-5 induced chemotaxis and these two receptors was analyzed in RNA and protein level. Mevalonate effect for the behaviors of simvastatin was also evaluated.
IL-5 in the dosage of 10 ng/mL had the most impressive enhancement on chemotaxis and CCR3 presentation for eosinophils harvested from HC15. Simvastatin inhibited IL-5-induced chemotaxis and CCR3 presentation in both mRNA and protein level but had no effect on IL5R. Mevalonate could reverse those inhibitory effects of simvastatin.
Simvastatin inhibited IL-5-induced chemotaxis of HC15-derived eosinophils by repression of CCR3 presentation instead of IL5R. This inhibitory effect of simvastatin acted via mevalonate pathway which could be reversed by mevalonate replacement.
Endoscopic dacryocystorhinostomy (DCR) is indicated for treatment of nasolacrimal duct obstruction, which manifests as a watery eye. Endoscopic techniques have gained popularity in recent years compared to open DCR, which leaves a facial scar. Success rates have been reported to be between 65-95%. We report the success rate of endoscopic DCR at our institution and analyze factors leading to revision surgery.
This is a retrospective analysis of endoscopic DCR performed at a district general hospital between August 2010 and December 2013. We perform this as a day case procedure using a DCR burr and leave silastic stents in situ. We do not routinely use anti-mitotic agents. We collected and analyzed demographic data (age, co-morbidity, medications), technical notes, rate of symptom resolution at follow-up, and need for revision surgery.
A total of 33 endoscopic DCRs were performed in this time period. The overall success rate (satisfactory resolution of symptoms at minimum 3 months follow up) was 76%. Rate of revision surgery was 15%. In 50% of cases scar tissue obstructing the DCR opening was the cause of surgical failure. Previous surgery (external DCR/punctoplasty) was not associated with a higher rate of endoscopic DCR failure (
Endoscopic DCR is a safe technique for treating nasolacrimal duct obstruction with local success rates of 76%. A common reason for failure is scar tissue obstructing the rhinostomy opening and greater attention is being given to surgical techniques that maintain wide patency of the opening, as this may reduce rates of failure.
S
In the mucin-producing human NCI-H292 airway epithelial cells and the primary cultures of normal nasal epithelial cells, the effect and signaling pathway of SEA on MUC5B expression were investigated using reverse transcriptase-polymerase chain reaction (RT-PCR), real-time PCR, enzyme immunoassay, and immunoblot analysis with several specific inhibitors and small interfering RNA (siRNA).
SEA increased MUC5B mRNA and protein expression. Toll-like receptor 2 (TLR2) mRNA expression was significantly increased after treatment with SEA. Knockdown of TLR2 by siRNA significantly blocked SEA-induced MUC5B mRNA expression. SEA significantly activated phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) and p38 mitogen-activated protein kinase (MAPK). U0126 (ERK1/2 MAPK inhibitor) and SB203580 (p38 MAPK inhibitor) significantly inhibited SEA-induced MUC5B mRNA expression. In addition, knockdown of ERK1/2 and p38 MAPK by siRNA significantly blocked SEA-induced MUC5B mRNA expression. Furthermore, the phosphorylation of ERK1/2 and p38 MAPK was significantly blocked by knockdown of TLR2 by siRNA.
These results show for the first time that SEA induces MUC5B expression via TLR2, ERK1/2, and p38 MAPK signaling pathway in human airway epithelial cells.
Evaluate the effect of functional endoscopic sinus surgery (FESS) for nasal polyposis on sleep efficiency and polysomnographic parameters.
This clinical trial was conducted on 15 patients with bilateral massive sinonasal polyposis who underwent FESS between August 2012 and September 2013. All participants were evaluated subjectively by employing the Pittsburgh Sleep Quality Index (PSQI) questionnaire and objectively (provided by polysomnographic parameters) before and 2 months after surgery.
The evaluation of subjective criteria of sleep quality assessed by PSQI showed significant improvement, particularly in nocturnal awakening (
This study documented the effect of resuming nasal cavity patency on improvement of sleep efficiency after FESS. In spite of insignificant effect of FESS on apnea index, alteration of other sleep parameters like arousal index following surgery may have a positive effect on sleep quality.
In order to study the role of vitamin D in the pathogenesis and manifestation of chronic rhinosinusitis with nasal polyposis, we designed the following study. In vivo: We tried to determine if serum vitamin D level was lower in patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) and if low serum vitamin D level correlated with the severity of CRSwNP. In vitro: We used the cultured nasal polyp–derived fibroblasts to investigate the in vitro effect of vitamin derivatives (calcitriol and tacalcitol) on the production of matrix metalloproteinase (MMP)-2 and MMP-9 .
Patients with latest diagnosis of CRSwNP undergoing elective endoscopic sinus surgery were recruited, and patients with malignancies or asthma were excluded. The severity of CRSwNP was assessed with the Lund-Mackay score and polyp grading system. Vitamin D status was assessed by measuring circulating 25-hydroxyvitamin D (25OHD) by using commercial chemiluminescence immunoassay. Resected polyps were used for primary fibroblast culture. The fourth to eighth passage of human fibroblasts were used for the experiments.
Serum 25OHD levels (ng/mL ± SD) were significantly lower in patients with CRSwNP (21.4 ± 5.7) than in those with CRSsNP (28.8 ± 6.2) (
A significantly lower vitamin D level was found in a group of Taiwanese CRSwNP patients, which revealed an association with greater nasal polyp size. The study on the influence of vitamin D on inflammatory processes in NP may shed a light not only on the mechanism of its etiology but also prove its potential use in the pharmacology of NP.
Septal perforation is one of the unwanted complications of septal surgery. The effects of perforation may change according to the location of the perforation, but anterior septal perforation may give rise to crusting and bleeding. Sometimes minor perforations may cause a whistling sound while breathing.
We included 9 patients who had septal perforation caused by septal surgery. All perforations were located anteriorly and their diameter was between 2 and 3 cm. In one case, the septum was almost totally perforated, and we closed the perforation with auricular conchal cartilage. This study was done in Canakkale Military Hospital between 2010 and 2013. All subjects were males between the ages of 20 and 23 years. All had previously been operated on for septal deviation. Their main complaint was nasal stuffiness and epistaxis. An open approach rhinoplasty was done. In order to expose both septal perforation flaps, we separated upper lateral cartilages. The cartilage graft harvested from conchal cartilage was trimmed and sutured transseptally that fits perforation dimensions.
Nasal tamponade for stabilizing the graft were kept in place for 10 days. The graft stability was examined monthly for 3 months. The main criteria for surgical success was mucosal integrity and postoperative crusting in nasal passages. Eight of 9 cases were fully closed by conchal graft. In 1 case, the partially posterior part of the perforation was left open, but this perforation was asymptomatic.
Auricular conchal graft usage in treatment of large septal perforations is an effective method.
(1) Effectiveness of intranasal ciclesonide 200 mcg qd (CIC). (2) Time-of-day predominance (TDP) of nasal and nonnasal AR symptoms. TDP is the main focus of this report.
Phase IV, open-label, noninterventional study. Patients aged 12 years with at least a 2-year history of AR were eligible; 1526 patients with active AR were enrolled and received CIC during 4 weeks. TDP was recorded by patients and classified as: Morning, noon, afternoon, night or none. TDP was evaluated at T0 (basal), once daily during the first treatment-week, and once a week during the rest of the study (weeks 2 to 4). Relative frequencies of AR symptoms were calculated with corresponding 95% confidence intervals. Differences between basal TDP-relative frequency and at treatment-days 7 and 28, were calculated using z test.
All symptoms were of morning predominance at baseline, for example, runny nose 51%, nasal congestion 51%, sneezing 49%. Morning predominance remained the highest for all evaluated symptoms during CIC-treatment period, but its frequency decreased after 7 and 28 treatment-days; as a result, the no-predominance category increased in frequency during the follow-up. Symptoms showed relative lower probability density after treatment as compared with basal evaluation: Between 0.53 and 0.57 at treatment day 7, and between 0.34 and 0.38 at day 28. All
In this study, TDPs for individual AR symptoms are described in a Mexican population. Treatment with CIC helps to reduce morning predominance of AR symptoms, and increases the asymptomatic state after 4 weeks of treatment.
Sleep loss is problematic in adults and children. Decline in sleep duration has paralleled an increase in the prevalence of obesity and diabetes. The aim of this study was to analyze the association between sleep duration, severity of obstructive sleep apnea (OSA), and metabolic variables in obese children.
In this study, patients between the ages of 2 and 12 years who had overnight polysomnography (PSG) at a tertiary care medical center were included. Patients were identified from a xenobase search of medical records. All patients had lipid levels, blood glucose, and insulin evaluated within 3 months of PSG. The demographics, laboratory data, body mass index (BMI), and blood pressure were collected from the medical records.
A total of 31 patients were studied. Twenty-one (67.7%) were male, and the mean age of patients was 8.5 ± 1.9 years. The mean BMI z score was 2.7 ± 0.81. All patients were obese. Patients were categorized into groups with total sleep duration >6 hours and <6 hours. Sixteen patients slept <6 hours and 15 patients slept >6 hours. There was no statistical difference in the lipid variables and blood pressure in these patients. A nonsignificant trend of decreased sleep duration with an increase in severity of OSA was observed. Blood sugar was significantly increased in patients with sleep <6 hours (100.2 ± 8.1 mg/dL) when compared with patients with sleep >6 hours (95 ± 4.4 mg/dL;
Short sleep duration is associated with insulin resistance in obese children with OSA.
Determine the safety of ambulatory oropharyngeal surgery in adults with obstructive sleep apnea.
Retrospective cohort study. Relevant data were collected from patients aged 18+ years with obstructive sleep apnea (OSA) receiving head and neck airway surgery between September 1, 2005, and September 15, 2012.
Out of 315 patients with complete data, 243 (77.14%) were managed as inpatients and 72 (22.86%) in an ambulatory manner. The mean Apnea/Hypopnea Index (AHI) for the inpatient and ambulatory groups were 35.99 and 18.43, respectively (
When evaluating body habitus and polysomnographic data, OSA patients who underwent oropharyngeal procedures and were discharged on the same day were significantly different than those who were admitted to the hospital. It appears from this data that patients with mild-moderate sleep apnea, even for patients with mild obesity, are safe to have these procedures performed in an ambulatory setting. This data could potentially assist practitioners in determining which procedures could be safely planned for an ambulatory setting and therefore decrease health care expenditures and patient inconvenience while maintaining patient safety. Future studies investigating what, if any, inpatient interventions were provided for those patients that were admitted to the hospital could potentially further expand the group of patient who could be safely managed in an ambulatory setting.
Obstructive sleep apnea (OSA) is commonly associated with neuropsychological sequelae, presumably induced by brain injury resulting from intermittent hypoxia. Newer magnetic resonance imaging modalities allow a more accurate examination of fiber integrity of the brain microstructure. Diffusion tensor imaging (DTI) is sensitive to the microstructure of brain tissue. This study is to evaluate the integrity of white matter in OSA patients with DTI.
The subjects underwent a polysomnography study to determine the severity of OSA and DTI scans to detect fiber integrity. Fractional anisotropy (FA), a measure of fiber integrity, was derived from the diffusion tensor, resulting in a whole brain FA map. The FA maps were compared using voxel-based statistics to determine differences between severe OSA and control groups, with age and sex as a covariate. The correlation between FA value and clinical severity was performed.
Twenty patients with severe OSA (apnea/hypopnea index, AHI >30/h) and 14 sex- and age-matched healthy volunteers (AHI <5/h) were recruited. The exploratory group-wise comparison showed that severe OSA patients exhibited reduced FA values in several brain clusters, including the white matter underlying amygdala, superior temporal gyrus, inferior parietal lobule, precuneus, postcentral gyrus, anterior cingulate gyrus, claustrum, insula, basal ganglia, tapetum, and cerebral peduncle compared with controls. The FA values were negatively correlated with clinical disease severity.
This study indicates that OSA patients have impaired white matter integrity in vulnerable regions, associated with increased disease severity. The findings likely represent the pathological process of the brain in OSA patients.
Determine if performing drug-induced sleep endoscopy (DISE) and trans-oral robotic surgery (TORS) for the treatment of obstructive sleep apnea (OSA) is associated with improved outcomes and acceptable complication rates when compared to traditional surgical procedures without DISE.
A retrospective, nonrandomized chart review. Patients with OSA who underwent uvulopalatopharyngoplasty (UPPP) in 2011 were compared with a prospective, nonrandomized group of patients with OSA who underwent DISE with other indicated procedures from 2012-2013 at a major tertiary care center. The pre- and postoperative apnea-hypopnea index (AHI), pre- and postoperative Epworth Sleepiness Scale (ESS), and major complication rate were compared.
Forty patients underwent UPPP without DISE. These patients showed a significant reduction in AHI –20.1 (
There was no significant difference in AHI or ESS in patients who underwent UPPP without DISE compared to patients who underwent DISE with other indicated procedures including TORS. Patients who had DISE and TORS surgical interventions for OSA demonstrated an increase in the rate of major complications.
Evaluate the changes of sleep quality in patients using a mandibular advancement device (MAD) for obstructive sleep apnea (OSA) based upon cardiopulmonary coupling (CPC).
A total of 52 patients (mean age, 53.7 ± 9.6 years; range, 33-74 years) were included in this study. Of them, there were 47 males (90.4%). All subjects were diagnosed with OSA after in-laboratory full-night polysomnography and re-evaluated after 3-month use of a MAD. At baseline, apnea-hypopnea index (AHI) was 33.6 ± 17.0. We compared CPC parameters at baseline with those after 3 month use of a MAD.
Low frequency coupling (59.5 ± 16.1 to 47.7 ± 14.8%,
Low frequency coupling decreased as AHI improved while high frequency coupling increased as AHI improved. The CPC parameters showed that the sleep quality was improved by MAD therapy.
Prospectively investigate the cardiovascular autonomic function in patients with obstructive sleep apnea (OSA) and examine the relationship with OSA severity, since impaired cardiovascular autonomic response is independently associated with cardio- and cerebro-vascular disease.
Ninety-one subjects with symptoms of sleep-disordered breathing who underwent full-night polysomnography were recruited. Standard autonomic parameters which include heart rate response to deep breathing, Valsalva ratio, baroreflex sensitivity (BRS), and heart rate variability were obtained for further analysis and correlated to severity of OSA.
Seventy-three patients with OSA (apnea/hypopnea index, AHI ≥5/h) and 18 simple snore patients (AHI <5) as normal control were compared in this study. BRS was the only parameter with significant difference among the 2 groups (3.6 ± 1.2 in simple snore and 2.8 ± 1.4 in OSA patients,
This study shows OSA patients have blunted baroreceptor function compared to patients without OSA. Baroreceptor dysfunction may contribute to an increase in cardiovascular morbidity in OSA patients.
(1) Determine the effectiveness of expansion sphincter pharyngoplasty (ESP) in the treatment of moderate and severe obstructive sleep apnea (OSA). (2) Be able to analyze the effects of the ESP on the sleep stages of patients with moderate and severe OSA. (3) Confirm changes in oxygen saturation after surgery.
A retrospective review of a prospective data set of 20 patients with moderate and severe OSA who underwent ESP. Patients studied were adults with small tonsils, body mass index less than 30 kg/m2, Friedman stage II or III, and type I Fujita. Charts between 2010 to 2014 were reviewed, and preoperative and postoperative polysomnographic values were analyzed.
Eighteen patients (90%) undergoing ESP showed some improvement. The surgery was effective in the treatment of severe and moderate obstructive sleep apnea syndrome (OSAS;
ESP is a valid therapeutic option for the treatment of OSA, and showed better results in severe cases rather than moderate ones. There are variations in the sleep stages that must be considered after this surgery. The surgical technique can bring benefits in oxygen saturation in patients with OSAS.
Determine if hypopharyngeal surgery for obstructive sleep apnea is associated with significant morbidity in the early postoperative period.
Medical records review and retrospective telephone survey of patients who underwent hypopharyngeal surgery for obstructive sleep apnea between November 2012 and September 2013 at a tertiary care facility.
Twenty-two patients underwent hypopharyngeal surgery for obstructive sleep apnea. No patient experienced intraoperative complications, postoperative O2 desaturation <90%, prolonged admission for inadequate pain control, pulmonary edema, or airway compromise requiring re-intubation. Postoperative complications included 1 episode of nasal hemorrhage, 1 infection requiring hospitalization, and 1 episode of dehydration treated with IV fluids. Twenty-five percent of patients experienced some degree of postoperative dysphonia, and 87.5% of patients experienced postoperative dysphagia. The average rating for postoperative pharyngeal pain was 3.5 by week 3 and 1.75 by week 4. Most patients described decreased snoring (93.75%), improved feeling of overall health (75%), and increased daytime energy (62.5%). All patients undergoing hypopharyngeal airway surgery were discharged within 23 hours.
Hypopharyngeal surgery is a safe and well-tolerated procedure for the treatment of OSA. Our findings suggest that hypopharyngeal surgery may be performed on an outpatient basis.
Obstructive sleep apnea (OSA) is a common sleep disorder due primarily to upper airway obstruction. Certain ethnic groups, particularly Chinese, are more susceptible to a severe degree of OSA irrespective of body weight due in part to inherent narrow upper airway anatomy. In this study, we investigated the treatment outcome of combined upper airway surgeries: septoplasty (SP), turbinate reduction (TR), tonsillectomy, and uvulopalatoplasty (UVPP) on OSA in this ethnic group who have clinical identifiable upper airway anatomical obstruction and are unable to tolerate continuous positive airway pressure (CPAP) treatment.
A retrospective study to analyze the effect of either: (1) SP and TR (inferior turbinectomy) only or (2) in combination with UVPP (partial uvulectomy and lateralization of palatal pillars) and standard tonsillectomy, on Chinese patients diagnosed with OSA. Outcome measures were obtained from pre- and postoperative polysomnographs (PSG) where sleep parameters, AHI, and oxygen saturation were analyzed.
Patients with only SP and TR (n = 20) failed to produce significant changes in sleep efficiency, sleep arousal (either spontaneous or respiratory related), or AHI measures. Conversely, patients with UVPP and tonsillectomy in combination with TR and SP (n = 16) had nearly 50% reduction or more in all categories of AHI (supine, non-supine, REM, and non-REM) observed (
The current study supports a greater role of upper airway and palatal surgery as a primary treatment of choice for this ethnic group with definable upper airway obstruction who failed or are unable to tolerate CPAP treatment.
Apply a new method of analyzing swallowing biomechanics on postoperative obstructive sleep apnea (OSA) patients using parameters of the modified barium swallow (MBS) imaging.
This novel biometric analysis involved two patients following uvulopalatopharyngoplasty, relocation pharyngoplasty, and base of tongue resection for OSA. Postoperative MBS indicated mild swallowing impairment in both patients. Coordinates mapping 10 anatomical landmarks were collected from every frame of the oropharyngeal swallow using ImageJ software. A canonical variate analysis was performed using MorphoJ software with data pooled by subject (S1, S2) and swallowing phase (OP = oral phase, PP = pharyngeal phase). The Mahalobonis distances (D) of the pooled means from each group were defined. Eigenvectors of shape change in these patients were compared to previously published subjects (non-surgical) to document changes in swallowing mechanics.
Significant differences in shape change were found for all values: OP versus PP of S1(D = 9.2,
Tongue base retraction and reduced pharyngeal shortening was noted in this small cohort of patients. These observations are consistent with the postoperative goal of necessary tightening in these areas to avoid collapse. Future controlled studies should be performed to determine whether these changes in swallowing mechanics are specific to surgical interventions or the underlying morphology of OSA patients. This method could potentially be used to quantify the effectiveness of sleep surgical techniques.
Evaluate the tolerability and effectiveness of the Barbed Roman Blinds Technique (BRBT), a new non-resective procedure in which the tenso-structural modifications of the fibro-muscular tissues of the soft palate and the lateral pharyngeal walls, created by means of barbed sutures (QUILL), reduce the collapsibility of the retro-palatal space.
A prospective study was carried out at the Ospedale Maggiore Policlinico University of Milan, Italy, from September 2012 to June 2103. Twelve snoring patients with mild obstructive sleep apnea syndrome (OSAS; AHI <20) underwent drug-induced-sleep-endoscopy and contextual BRBT under general anesthesia. Patient satisfaction was measured with visual analog scale (VAS), snoring with linear-analog-scale (LAS) and snoring-scale-score (SSS), daytime sleepiness with Epworth Sleepiness Scale (ESS). Polysomno-graphy was repeated 6 months postoperatively.
Eight males and 4 females, median age 47.5 years (range, 38-61 months) had no significant postoperative morbidities or complications. The most common complaint was mild swallowing pain with spontaneous resolution within 5 to 7 days. After a median follow-up of 10 months (range, 15-8 months), a stable space-structural remodeling of the velo-uvulopharyngeal tissues was observed; improvement of snoring was confirmed by reduction in LAS and SSS; high VAS satisfaction values and reduction of ESS and AHI were recorded.
BRBT represents an effective, nonresective, reversible, repeatable and well-tolerated procedure to relieve snoring. Considering the observed reduction of AHI and ESS, the role of BRBT in moderate-severe OSAS is currently under study.
Up to 14% of the US population is estimated to have obstructive sleep apnea (OSA) related to obesity. Other than continuous positive airway pressure, treatments have had variable results since the exact site(s) of obstruction and the optimal method of modifying those sites with devices or surgery can be difficult to establish. We introduce a technique for modeling the upper airway that shows the behavior of the airway and predicts the location of collapse in OSA.
Accurate modeling of air to solid fluid-structure interaction, challenging to model in the past, was accomplished using ANSYS software applied to a 3-dimensional rendering of an OSA patient’s airway (with an AHI of 87.6/h) using thin-cut computed tomographic scan data. Viscoelastic properties of the pharyngeal walls, tongue and palate, not previously well characterized, were measured using 5 fresh porcine cadaver heads with a Bose ElectroForce test instrument with Dynamic Mechanical Analysis software. Various dynamic displacements were applied to tissue samples and associated forces measured simultaneously to obtain dynamic material properties.
Areas of lowest pressure during inspiration were identified as likely regions of collapse during apneic episodes, such as the base of the tongue with pressures as low as –4730 Pa (–48.23 cm H2O), similar to values reported in human esophageal pressure measurements in upper airway resistance syndrome.
This novel investigation virtually and accurately models the upper airway in OSA, and allows virtual modification of the airway to predict effects of treatment.
Obstructive sleep apnea (OSA) is increasingly a concern for a risk factor of poor pregnancy outcomes. However, to date, most research studies have relied on subjective research such as Epworth Sleepiness Scale (ESS). Therefore, our research design used polysomnography, which is an objective measurement to define OSA in pregnancy. The study aimed to measure the incidence of OSA in pregnancy, to reveal clinical examination which will be objective screening tool for OSA in pregnancy, and prove that OSA is a risk factor of poor pregnancy outcomes.
Fifty healthy pregnant women who received antenatal care at Chiangmai University Hospital during October 2012 through April 2013 were measured by physical examination and polysomnography at GA 28th to 32nd weeks, and followed until the end of pregnancy to see the difference of poor pregnancy outcomes in OSA and non-OSA group.
The incidence of OSA in pregnancy was 12%. OSA related to more overall poor pregnancy outcomes (relative risk [RR] = 5.86 [2.16-15.96],
OSA could lead to a high-risk pregnancy, which should be screened by multidisciplinary teams, to establish diagnosis and treatment for maternal and child health.
Continuous positive airway pressure (CPAP) has become the standard of care for obstructive sleep apnea (OSA). However, CPAP compliance has been shown to be poor and surgical correction of upper airway may be an option for selected patients. The study aimed to assess the outcomes of patients presenting to sleep disorder clinic with OSA.
Subjects were identified by reviewing sleep laboratory records of patients presented for full polysomnography from 2010 to 2014. Case notes were traced and data collected retrospectively. The treatment prescribed include weight reduction, CPAP, surgery and oral appliance. The outcomes of treatment options offered were analyzed and full polysomnography parameters before and after treatment were compared.
Less than 20% of patients underwent surgical correction of the upper airway. Less than 50% of the patients used an oral appliance. More than 60% of patients showed improvement in the respiratory disturbance index (RDI) after the surgery. About 80% of patients defaulted treatment subsequently. A small proportion of patients were discharged from the sleep disorder clinic after significant improvement of symptoms.
Surgery is indicated in patients who have a specific underlying abnormality causing the OSA and if they refused or failed CPAP therapy. However, only a small proportion of patients have such correctible lesions.
(1) Describe each patient’s preoperative and postoperative experience in the treatment of obstructive sleep apnea (OSA). (2) Understand how the patients’ perceptions may influence their postoperative outcome and satisfaction.
To analyze the differences between quantitative and qualitative postoperative results, we developed a modified phenomenological qualitative study of OSA patients who failed continuous positive airway pressure use and underwent surgery. From May to August 2012, patients were interviewed using a semi-structured approach until thematic saturation was reached (n = 17). Of these interviews, 13 were held in-person while 4 were performed by phone. Through Moustakas’ analysis, the transcribed interviews were broken down into codes. These were grouped into overarching themes. Upfront debriefing, investigator triangulation, epoche, reciprocal coding, member checks, and thick, rich description ensured data trustworthiness. Additionally, the patient’s preoperative sleep studies and postoperative sleep studies were analyzed and compared to the subjective results.
The study identified 5 themes relating to patients and their OSA surgery: (1) Importance of OSA on personal and professional life; (2) Motivating factors for choosing surgery; (3) Patient knowledge; (4) Postoperative challenges; (5) Impact of OSA surgery.
Patients’ experiences going into the surgery can largely influence their perceived outcome and satisfaction. These experiences are individual and subjective, and the postoperative sleep studies do not capture the whole outcome of the patients’ response to surgery. This suggests when patient reported outcomes are combined with postoperative sleep studies, otolaryngologists can gain a much better perspective about their patients.
Determine the prevalence of high risk for obstructive sleep apnea (OSA) in general Thai population by using the STOP-Bang questionnaire.
Anonymous survey was conducted in Thailand at Health and Wellness exhibition. The exclusion criterion was age <18 years. The STOP-Bang questionnaire was used in the survey. This questionnaire consisted of 4 simple yes/no questions: snoring, tiredness, observed apneas, blood pressure, and 4 clinical characteristics which were dichotomized according to specified cutoffs; body mass index >35, age >50 years, neck circumference >40 cm, sex = male. Scores of at least 3 were considered high risk for OSA. Epworth sleepiness scale (ESS) as well as detailed demographic information related to several aspects of sleep was also obtained.
The study included 414 Thai adults. The mean age of participants was 51 years old. Of the 414 participants, 305 participants (76%) were classified as high risk for OSA. High risk for OSA group was observed to have more males (88%). The STOP-Bang yielded a mean score of 3.65. One hundred seventy-two participants (41%) were noted to have excessive daytime sleepiness (ESS score >10). There was a significant correlation between STOP-Bang questionnaire score and Epworth sleepiness scale score (
Over 70% of participants were identified as having high risk for OSA based on the STOP-Bang questionnaire. Considering the serious adverse health and quality of life consequences of OSA, screening for OSA in general populations should be attempted.
Few investigations have examined oral flow (OF) patterns during sleep. This study aimed to clarify the relationship between OF patterns, nasal airway obstruction, and obstructive respiratory events.
Nasal flow and OF were measured separately by polysomography. OF was measured 2 cm in front of the lips using a pressure sensor. Subjects were categorized into 2 groups: those with nasal obstruction (n = 44) and those without nasal obstruction (n = 41).
OF could be divided into 3 patterns: postapneic OF, OF during flow reduction (OF during FR), and spontaneous arousal-induced OF (SpA-induced OF). Postapneic OF refers to OFs that begin at the end of obstructive respiratory events (eg, flow limitation, hypopnea, and apnea), are preceded by respiratory arousals, and are accompanied by postapneic hyperventilation. OF during FR refers to OFs that occur during respiratory event-like nasal flow reduction. SpA-induced OFs are OFs that begin during stable breathing, are preceded by spontaneous arousal but not accompanied by apnea or hypopnea. Multivariate regression analysis showed that nasal obstruction was predictive of SpA-induced OF. Only 1.3% of SpA-induced OF led to apnea or hypopnea. SpA-induced OF showed a negative correlation with the apnea-hypopnea index.
Postapneic OF and OF during FR led to apnea or hypopnea and were typical patterns seen in patients with moderate and severe sleep-disordered breathing (SDB). By contrast, SpA-induced OF was not associated with apnea or hypopnea but functioned as a “nasal obstruction bypasser” seen mainly in normal subjects and patients with mild SDB.
Compare polysomnography (PSG) results before and after transoral robotic lingual tonsillectomy (TORLT) in patients with obstructive sleep apnea (OSA).
Lingual tonsillar or base of tongue hypertrophy can be a cause of OSA but has proven difficult to address because of difficulty in accessing this area of the oropharynx through traditional surgical techniques. TORLT provides a simple, minimally invasive surgical technique for lingual tonsillectomy. Patients with OSA symptoms were assessed with preoperative PSG and sleep endoscopy for base of tongue obstruction. Selected candidates underwent TORLT followed by repeat PSG and nasal endoscopy after full recovery from the procedure. The pre- and postoperative PSG data were compared for each patient. Nonparametric comparisons were made using the signed rank test becasue of small sample size.
Ten patients underwent preoperative PSG and subsequent TORLT. Postoperative polysomnography data as available for 8 patients. Pre- and postoperative PSG comparisons (pre, post,
Transoral robotic lingual tonsillectomy improved polysomnography measures but not to a level of significance. This study is limited by small sample size and associated limited statistical power. Further study with larger sample sizes should be undertaken to more definitively study outcomes for this surgical technique.
None provided.
In this prospective clinical study, 41 adult patients (32 males, 9 females) diagnosed for obstructive sleep apnea syndrome (OSAS) and operated at university hospital by anterior uvulopalatoplasty between December 2008 and December 2010 at least 6 months (median 10.0 months) before investigation, formed the study group. A total of 17 nonoperated OSAS patients matched by age, sex, smoking rate, and OSAS severity served as controls. Post service with questionnaires and telephone conversation was accomplished. Patient and control symptoms (hoarseness, nasality of voice, and dysphagia) were assessed using 10-point Likert scale (1-normal). Voice quality was assessed by voice handicap index (VHI), and hypernasality by auditory perceptual Gutzmann hypernasality test.
Hoarseness ratings for OSAS patients were similar before and after the surgery, with no significant impact on voice handicap. Moreover, total VHI score significantly dropped after the surgery from 9.2 points to 5.4 points out of maximum 120 (
Anterior uvulopalatoplasty does not result in significant changes in voice, nasality and swallowing when rated by OSAS patients and by clinical assessment.
(1) Identify surgeon dependent and temporal variations in indications and surgical interventions for obstructive sleep apnea (OSA) at a tertiary academic hospital. (2) Clarify if volume of sleep surgeries performed affects outcomes. (3) Determine if surgical volume correlates with technical variation (ie, do surgeons who perform more surgeries for OSA perform additional procedures beyond uvulopalatopharyngoplasty [UPPP]).
Retrospective chart review: Adult patients who had undergone UPPP since 2003 and had electronic medical records available were included. Quality of life (QOL) instruments included in the electronic medical record such as the Epworth Sleepiness Scale (ESS) and the Functional Outcomes of Sleep Questionnaire (FOSQ) were included. Pre- and postoperative results were compared using standard statistical analysis.
A total of 247 patients met inclusion criteria. Median AHI of all patients with available postoperative PSG decreased from 39.4 to 21.4. Patients of high-volume surgeons (>10 UPPP per year) were more likely to have a lower preoperative Friedman score (
UPPP contributes to objective improvement in PSG measures and quality of life. Nuances in patient selection and patient management are apparent between high volume surgeons and others, and may contribute to quality of life variations. Standardization of patient selection, timing of postoperative PSG, and increased utilization of QOL instruments may improve QOL outcomes among surgeons who do not perform UPPP regularly.
Investigate whether the retropalatal airway collapsibility defined by regular endoscopy with Müller’s maneuver could be used for predicting position independency and apnea-hypopnea index (AHI) in patients with obstructive sleep apnea (OSA).
This was a retrospective study and a total of 77 polysomnographies (mean AHI = 25.75 ± 22.69) and 77 awake endoscopies with Müller’s maneuver between January 2010 and October 2013 were reviewed from 45 OSA patients (40 men and 5 women; mean age, 40.7 ± 1.6 years). Transverse/longitudinal diameters and collapsibilities of the airway at the level of the uvular base were measured using a picture archiving and communication system. Intra- and interrater reliabilities were assessed. Associations among the retropalatal airway dimensions, AHI (total, supine, and lateral), and position independency (defined as a supine AHI of <2 times of the lateral AHI) were statistically analyzed.
Measurement of transverse diameters and transverse/longitudinal collapsibilities was highly reliable within and between raters (all intraclass correlation coefficients >0.8) but longitudinal diameters measurement was less reliable. Transverse collapsibility significantly correlated with position independency (
Regular endoscopy with Müller’s maneuver continues to be an important clinical tool to evaluate the upper airway among OSA patients and a high transversely retropalatal collapsibility is a hallmark of non-positional and/or severe OSA.
Recognize the correlation between WatchPAT and Polysomnography (PSG) results including the apnea-hypopnea index (AHI), respiratory disturbance index (RDI), and oxygen desaturation index (ODI).
A systematic literature review was performed by searching Pubmed, OVID Medline, and the Cochrane database for articles from June 2000 comparing WatchPAT to PSG. Meta-analysis of continuous measures using the fixed effect model was performed.
Twelve studies that directly compared the results of AHI, RDI, and ODI between WatchPAT and PSG were identified. Five of the 12 studies, involving a total of 476 patients, measured AHI. WatchPAT AHI was not found to be significantly different from PSG AHI (standardized mean difference [SMD], 0.10; 95% confidence interval [CI], –0.08 to 0.28). RDI values, obtained from 5 studies with a total of 612 patients, did not significantly differ between WatchPAT and PSG (SMD, 0.08; 95% CI, –0.07 to 0.24). No significant difference was found between WatchPAT ODI and PSG ODI values from 2 studies with a total of 298 patients (SMD, 0.11; 95% CI, –0.12 to 0.34).
The respiratory indices provided by WatchPAT are comparable to those obtained by PSG. This meta-analysis reinforces the validation of WatchPAT as an alternative to PSG in the diagnosis of obstructive sleep apnea (OSA). With WatchPAT, patients can be evaluated in their own habitual environment rather than in a sleep lab. Therefore, the use of WatchPAT provides a less stress-inducing option for patients and a more financially efficient method for the evaluation of OSA.
Obstructive sleep apnea affects over 15% of the population, presenting a major health burden. Research has focused on exploring imaging modalities that supplement polysomnography, eliciting potential sites of airway obstruction. While computed tomography (CT) imaging and sleep endoscopy have been used to accurately assess the posterior airway space (PAS), sedated endoscopy is invasive, and repeated CT imaging risks higher radiation exposure and does not assess the dynamics of the tongue base and PAS. We propose the use of modified barium swallow study as a simple modality to measure PAS. Advantages include its simplicity, lower radiation, and dynamic tongue base visualization, which may help predict surgical outcomes. We hypothesize cephalometric measurements obtained using modified barium swallow (MBS) will correlate well with CT.
Retrospective chart review, tertiary care hospital. Thirty-six adult patients who underwent both CT imaging and MBS for head and neck cancer were included. Cephalometric measurements of the PAS were obtained using each imaging modality. Statistical analysis focused on correlating measurements taken using CT or MBS.
The average PAS measurements were 12.53 ± 1.81 mm and 12.80 ± 1.75 mm when using MBS and CT imaging, respectively. There were no statistical differences based on age, sex, or cancer site. In comparing the 2 modalities, Pearson correlation between CT and MBS measurements revealed an extremely significant positive correlation between
Cephalometric measurement of the PAS using MBS appears to correlate well with CT imaging. These data suggest MBS may be an effective way to assess the PAS in patients with OSA.
Perform an updated systematic review and meta-analysis to determine the surgical success rate of multilevel upper airway surgery for patients with obstructive sleep apnea syndrome (OSA).
A systematic review was performed to identify English-language studies that evaluated the treatment of adult OSA patients with multilevel OSA surgery up to May, 2013. We used polysomnography as a metric of treatment success. Articles were included only if the surgery intervention involved at least 2 of the frequently involved anatomic sites: nose, oropharynx and hypopharynx. Seventy-three studies fit the inclusion criteria and a meta-analysis was performed to determine the overall success.
The meta-analysis included 3147 subjects with a mean age of 45.0 years. The originally reported success rate in the included literature was 59.8%. A meta-analysis was performed to redefine the success rate to be consistent with the commonly agreed upon criteria, “a reduction in AHI [apnea-hypopnea index] of 50% or more and an AHI of less than 20.” The recalculated success rate was 61.4%. Standard meta-analytic techniques for combining p-values between studies after weighting for sample size found significant improvements in AI, AHI, %REM sleep, LSAT, snoring visual analog scale, and Epworth Sleepiness Scale.
This study shows the significant benefits of multilevel surgery for OSA patients.
