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In this study, we investigated the feasibility of an intracranial catheter transducer with dual-mode capability of real-time 3D (RT3D) imaging and ultrasound hyperthermia, for application in the visualization and treatment of tumors in the brain. Feasibility is demonstrated in two ways: first by using a 50-element linear array transducer (17 mm × 3.1 mm aperture) operating at 4.4 MHz with our Volumetrics diagnostic scanner and custom, electrical impedance-matching circuits to achieve a temperature rise over 4°C in excised pork muscle, and second, by designing and constructing a 12 Fr, integrated matrix and linear-array catheter transducer prototype for combined RT3D imaging and heating capability. This dual-mode catheter incorporated 153 matrix array elements and 11 linear array elements diced on a 0.2 mm pitch, with a total aperture size of 8.4 mm × 2.3 mm. This 3.64 MHz array achieved a 3.5°C in vitro temperature rise at a 2 cm focal distance in tissue-mimicking material. The dual-mode catheter prototype was compared with a Siemens 10 Fr AcuNav™ catheter as a gold standard in experiments assessing image quality and therapeutic potential and both probes were used in an in vivo canine brain model to image anatomical structures and color Doppler blood flow and to attempt in vivo heating.

26:T44c,

An efficient ultrasound beamforming algorithm based on sigma-delta modulation (SDM) is proposed, which performs dynamic focusing at the Nyquist rate as in conventional delay-sum beamformers. Specifically, a block of consecutive SDM samples for each focal point is selected on each channel according to the focusing delay. The data blocks for all channels are then added up on a bit-to-bit basis and the resulting block of multibit samples is fed to the demodulation filter to produce the focused signal. Since the SDM samples in each data block are not altered at all, the proposed method does not cause any signal distortion. Two hardware structures are also proposed for minimum hardware implementation of the proposed error-free SDM beamforming method. It is verified that compared to the delay-sum beamformer using 10-bit ADCs, the proposed algorithm provides almost the same image quality with a greatly reduced hardware complexity. In addition, it can be implemented with a lower hardware complexity than that of the conventional SDM beamformer when the number of channels is 64 or less.

27:T488,

2-D spatial compounding has long been investigated to reduce speckle in ultrasound images. To further reduce speckle, several 3-D spatial compounding studies using 1-D and 1.5 D arrays with mechanical translation and position tracking have bee