
Abstract
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Upper tract urothelial carcinoma (UTUC) accounts for approximately 5% of all urothelial carcinoma. There are many risk factors for UTUC, including environmental and genetic risk factors, some of which are in common with bladder cancer. The gold standard surgical management of UTUC is radical nephroureterectomy (RNU) with excision of bladder cuff, which is increasingly being performed laparoscopically or robotically with various methods used for the distal ureter. There are increasing numbers of patients being treated endoscopically, with excellent oncological outcomes in low-grade disease. The use of topical BCG and chemotherapy agents has been extrapolated from bladder cancer and may be an adjunct to endoscopic management in those patients in whom it is imperative to avoid RNU.
We have reviewed articles published on penile prosthetic infection in Medline and EMBASE databases from 2000 to 2012 with the intention of signposting ‘best evidence’ for the UK prosthetic implanter. Using the Oxford Centre for Evidence-based Medicine Levels of Evidence (LE), no paper exceeded an LE of 2b and the majority were LE 4 (case series) and LE 5 (expert opinion). This is not surprising from a UK perspective since HES data for 2009 to 2010 reported 263 penile prosthetic surgeries performed in 35 hospitals, with only five hospitals performing 15 or more. Our literature review suggests that the use of antibiotic-coated IPPs and measures aimed at reducing inoculating bacteria into the surgical wound with alcohol skin preparation, a no-touch technique and peri-operative antibiotic use are most important in minimising the risk of device infection. The use of post-operative antibiotics is contentious (LE 5). It remains unproven whether diabetics have a higher rate of prosthetic infection compared to nondiabetics. In cases of re-implantation for mechanical failure, it remains debatable whether a washout technique should be used and indeed uncertainty remains regarding the pathological role of biofilm in the causation of device infection in this scenario. A washout technique during salvage penile prosthetic surgery for device infection is advocated. Further research on biofilm may offer the best chance of reducing the incidence of device infections overall.
Recent changes in practice standards and remuneration to UK Trusts have been refined to penalise institutions for patient readmission within 30 days of discharge. The purpose of this study was to determine if the target rate of less than 6.5% was attained within the setting of a district general hospital (DGH) and also to comment on readmission trends.
A retrospective study was performed over 12 months examining all unplanned readmissions to hospital 30 days following discharge from Urology. Elective as well as emergency cases were audited.
A total of 4124 patients were treated and discharged by the department over 12 months. One hundred and eighty-four (4.4%) patients were readmitted: 93 (51%) patients following acute presentations and 91 (49%) following elective procedures. The commonest causes for unplanned readmission were haematuria, 29 cases (16%), acute urinary retention, 28 cases (15%) and ureteric colic, 25 cases (14%). Readmission rates following flexible cystoscopy and TRUS biopsy were 1% and 3%, respectively. Only six of 70 patients (9%) were readmitted following TURP. Five (3%) of the 184 readmissions required a second procedure.
Our department met the predetermined standard in achieving an unplanned readmission rate of less than 6.5%. This study also highlighted the need for discharge policies for common acute presentations.
Laparoscopic radical prostatectomy (LRP) is an established treatment option for patients with prostate cancer in selected centres with appropriate expertise. The goal of LRP is to achieve excellent cancer control whilst attempting to preserve normal urinary continence and erectile function. We studied our single-centre experience evaluating the oncological outcomes in patients undergoing LRP.
Three hundred and six patients underwent LRP between 2005 and 2011. Patients were divided into D'Amico low-, intermediate- and high-risk groups.
The mean age was 61.9 years (range 46-74 years). The two most important factors predictive of positive surgical margins (PSMs) at LRP were the initial prostate-specific antigen (PSA) level and tumour stage at diagnosis. The overall PSM rate was 26.7%. For low D'Amico-risk patients, the PSM was 24.5%, intermediate-risk patients had a PSM of 32.4%, while high-risk patients had a PSM of 13.6%; 6.4% (nine of 139) of patients sampled had evidence of lymph node-positive disease. Five-year PSA progression-free survival rates were 83% in low-risk patients, 57% in intermediate-risk and 41% in high-risk patients.
LRP offers good oncological outcomes in the low- and intermediate-risk groups with low incidence of biochemical recurrence for patients with localised disease. Our high-risk group has a low incidence of PSM and a five-year PSA progression-free survival rate of 41%. Patients with high-risk, but non-metastatic, prostate cancer can be offered a minimally invasive prostatectomy in an experienced centre.
Patient information leaflets (PILs) are commonly used to improve the understanding of conditions and treatments. The Flesch-Kincaid Grade Level (FKGL) is a test used to evaluate the readability of a text with the score corresponding to the grade level of a student in the United States. The objective of our study was to assess the readability of PILs produced by the British Association of Urological Surgeons (BAUS), patient.co.uk and the American Urological Association (AUA).
All PILs from the BAUS and AUA websites and urology-related PILs on the patient.co.uk site were assessed. PILs were individually analysed to derive the word count, number of characters per word and the FKGL (readability score). The mean values from each source were compared.
Patient.co.uk PILs were significantly the most readable on average with an FKGL of 8.09 (
Although PILs produced by these large organisations may be easily readable by well-educated adults, comprehension may be difficult for a significant proportion of the United Kingdom adult population.
To determine the role of staging pelvic magnetic resonance imaging (MRI) in men with intermediate risk prostate cancer.
We identified all patients diagnosed with intermediate risk (NICE definition: PSA 10-20 ng/ml, or Gleason score 7, or clinical stage T2b/T2c) prostate cancer between 1st January 2007 and 31st December 2008. Through retrospective case note review, we determined the number of patients who had undergone a pelvic MRI and whether such an investigation had altered the patient's management by increasing tumour stage.
A total of 222 men (mean age 66 years; range: 48-88) were diagnosed with intermediate risk prostate cancer during our study period. The mean PSA was 11.8 ng/ml (range: 3-20 ng/ml). Of these, 112 (50.5%) underwent an MRI. Overall, in 25/112 (22.3%) patients, pelvic MRI findings impacted significantly upon patient treatment by demonstrating either extra-prostatic extension of cancer, lymph node involvement or bone metastases.
Our retrospective study has demonstrated that a pelvic MRI in men diagnosed with intermediate risk prostate cancer may influence treatment decision in approximately a quarter of patients. Routine pelvic MRI is indicated in men with intermediate risk prostate cancer where radical treatment is contemplated.
To evaluate whether “cross-leg lithotomy” (CL) is better position for digital rectal examination (DRE) than left lateral (LL) position from urologist and patient's perspective.
Two urologists performed DRE in 120 patients in LL and CL positions. Each patient was randomised, sequentially examined in both positions and responses were objectively assessed using a questionnaire and statistically analysed.
Men found DRE uncomfortable [LL (81.7%), CL (85.0%)] and embarrassing [LL: (81.7%), CL (78.3%)] in both the positions. DRE was painful [LL (11.7%), CL (8.3%)] with a mean pain score of 1.92 and 1.85 respectively. Patient apprehension regarding pain was significantly higher [LL (62.5%) vs. CL (21.7%),
Men preferred CL to LL position for DRE and CL allowed more complete examination of the prostate from urologist perspective. CL position is a better alternative for performing DRE of the prostate.
A 65-year-old man presented with a rapidly enlarging pre-auricular lump, with pruritis and contact bleeding. The patient was referred to dermatology due to the high index of suspicion for malignancy. Following excision of the lump and histological analysis it was found to be a metastasis from renal cell carcinoma. The patient had had a T1bN0M0 renal cell carcinoma excised over two decades previously, representing low risk disease. This case report highlights the need for a high index of suspicion in the management of all patients with a past history of malignancy.


Fournier's gangrene is a severe necrotising infection of the perineum. It is believed that the thick penile fascia restricts the penetration of infection and spares the internal structures. We present an unusual case of a 59-year-old apparently healthy man presenting with penile corporal Fournier's gangrene with no known predisposing or precipitating factors. His initial presentation was peno-scrotal pain, swelling and priapism with normal-looking skin surrounding his genitals. After the imaging studies, he was discovered with gas in his genital tissues which was leading to the priapism. Upon debridement his corporal muscle was found to be necrosed and he ended up having a penectomy. Histopathology confirmed the diagnosis. The patient, however, made a good recovery and was referred to the plastic surgeons for functional reconstructive surgery.

Transitional cell carcinoma (TCC) of the bladder is the most common urothelial malignancy. Sites of metastatic spread are usually predictable; typically the pelvic and para-aortic lymphatics, followed by extra-vesical tissues, i.e. liver, lung, bone and adrenal glands. There is currently little literature describing metastatic spread to the head and neck region, and none to the authors’ knowledge, of spread to the parotid salivary glands. This report describes a rare case of parotid metastasis of bladder TCC in a 75-year-old Caucasian woman.


