Abstract
Background:
Preliminary evidence suggests that acupuncture applied proximally during a single bout of exercise can enhance exercise performance and/or expedite postexercise recovery. The purpose of this investigation was to review trials, systematically and critically, that have investigated such hypotheses and delineate areas for future research.
Method:
A systematic review using computerized databases was performed.
Results:
Four trials were found: Three involved within-subjects designs and one used a parallel group design. Few participants were enrolled (n=10–20). Fourteen acupuncture sites were used across the four trials: DU 20, LI 15, LI 13, PC 6, ST 36, SP 6, PC 5, LU 7, LI 4, GB 37, GB 39, GB 34, and LI 11, and LR 3. PC 6, and ST 36 were the most commonly used sites. Three trials evaluated the effect of acupuncture on exercise performance. One of these trials noted that electroacupuncture stimulation of either PC 5 and PC 6 or LU 7 and LI4 significantly increased peak power output, blood pressure, and rate pressure product (RPP) versus control. However, two trials documented no effect of acupuncture on exercise performance using point combinations of either DU 20, LI 15, LI 13, PC 6, ST 36, and SP 6 or DU 20, ST 36, GB 34, LI 11, LR 3. One trial evaluated the effect of acupuncture on postexercise recovery and found that heart rate, oxygen consumption, and blood lactate were significantly reduced secondary to acupuncturing of PC 6 and ST 36 versus control and placebo conditions at 30 or 60 minutes postexercise.
Conclusions:
There is preliminary support for the use of acupuncture as a means to enhance exercise performance and postexercise recovery, but many limitations exist within this body of literature. Adequately powered, RCTs with thorough and standardized reporting of research methods (e.g., acupuncture and exercise interventions) and results are required to determine more adequately the effect of acupuncture methods on exercise performance and postexercise recovery. Future investigations should involve appropriate placebo methods and blinding of both participants and investigators.
Introduction
Acute and chronic exposure to acupuncture treatment has been found to elicit cardiovascular adaptation. For example, ongoing acupuncture treatment has been shown to reduce the frequency of angina attacks significantly, reduce ST-segment depression, and raise the ischemic threshold in individuals with diagnosed angina pectoris; compared with a placebo pill. 3 Single sessions of acupuncture treatment have been shown to significantly reduce systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) from pre- to postinsertion in patients with hypertension. 4 Moreover, Park et al. 5 recently demonstrated that a single session of acupuncture treatment could improve endothelial function significantly, measured via flow mediated dilation (FMD), in individuals with hypertension. Studies evaluating the effect of acupuncture on cardiovascular outcome measures have utilized a number of different acupoints. However, two acupoints in particular, Neiguan (PC 6), and Zusanli (ST 36), have been used consistently. 4 –7 PC 6 has been found to improve arterial distensibility from pre- to postinsertion, 8 and ST 36 has been found an increase FMD, 9 supporting the possibility that these could be important points for altering cardiovascular function.
The physiologic mechanisms by which acupuncture induces cardiovascular benefits remain to be elucidated. Data suggest that acupuncture can induce release of endogenous opioids. 10 β-Endorphins, in particular, have a high affinity to the μ-receptor which appears to be a key mechanism for modulating blood pressure (BP). 11 –14 Downregulation of the sympathetic nervous system (SNS) has also been implicated. For example, acupuncture can trigger a somatoautonomic reflex, 15 which can induce vasodilation. 16 Clinical manifestations of these effects include relaxation, calmness, and reduced distress. 17
Evidence suggesting that acupuncture may treat specific cardiovascular conditions effectively, and the relevance of the proposed mechanisms mediating this effect (e.g., vasodilation), has led to speculation that acupuncture may enhance exercise performance and postexercise recovery. For example, preliminary evidence suggests that EA of Jianshi PC 5 and PC 6 just prior to a maximal exercise test can significantly increase peak workload. 18 This novel application of acupuncture treatment as an ergogenic aid could be of particular interest to elite athletes and coaches who train to optimize cardiovascular adaptation and performance. However, such application may also be of importance to people exercising to obtain health-related benefits, including amelioration of chronic disease risk factors, such as patients with obesity and type 2 diabetes mellitus.
To date, a systematic review evaluating the effect of acute treatment on measures of exercise performance and postexercise recovery has not been undertaken. Therefore, the purpose of this investigation was threefold: (1) To review, systematically and critically, trials that have investigated the effect of acute acupuncture on measures of exercise performance and postexercise recovery (2) To summarize and contextualize the outcomes of these trials (3) To delineate areas for future investigation.
Method
Search
A literature review was conducted in July 2011 from the earliest available date to 2011, limited to the English language, using computerized databases: Medline,® Embase, PubMed, Google Scholar, and Scopus. The search combined key words related to acupuncture (i.e., acupuncture, electro-acupuncture, needle, and acupoint) and exercise (i.e., exercise, aerobic, training, sport, and physical activity). The articles retrieved were examined for further relevant references.
Criteria for considering studies
Study designs
Trials evaluating the effects of acute acupuncture on parameters of exercise performance and/or recovery were included, regardless of study design. Trials evaluating the effect of ongoing acupuncture treatment were excluded.
Participants
Trials involving adult participants (i.e., men and/or women age >18) were included. Trials enrolling children and/or adolescents were excluded.
Acupuncture interventions
Trials prescribing acute acupuncture needling or EA were included. Trials investigating other modalities of TCM or trials combining acupuncture with other therapies were excluded.
Exercise interventions
Trials evaluating the performance of, and/or recovery from, an aerobic exercise session (e.g., running or cycling) were included. Trials involving resistance exercises or combined exercise modalities (e.g., aerobic and resistance exercise) were excluded.
Outcome measures
Variables altered by physical exertion were considered. These outcomes were both physiologic and psychological in nature, including HR and rating of perceived exertion (RPE), for example.
Data extraction
Two authors (P.U. and B.C.) reviewed the retrieved articles and independently extracted information on sample characteristics, study design, outcome variables, relevant results, and if the study fulfilled the inclusion criteria. Sample characteristics included sample size, proportion of female and male participants, and if the participants had previously used acupuncture. Study design variables included experimental design, characteristics of the acupuncture treatment that was delivered, and how expectancies were either assessed or manipulated. Differences between the reviewers were discussed, and a final assessment was negotiated for each study.
Statistical analysis
Given the heterogeneity of the interventions and the paucity of robust RCTs, the pooling of effect sizes across studies for meta-analysis was not considered appropriate for this review. Instead, a descriptive review of the studies meeting the inclusion criteria was provided. Results were considered statistically significant when p was≤0.05.
Results
Studies retrieved and design
The search resulted in four articles presenting findings of independent trials. Three trials involved a within-subjects, crossover design with randomization, 18 –20 and one used a parallel group design. 21
Overview of the participants: Sample size, gender, age, and fitness level
An overview of participants, interventions and outcomes is presented in Table 1. Eighty-four (N=84) participants were enrolled in the four trials reviewed. Few participants were enrolled in each trial. One trial enrolled only 10 participants, 20 while the other trials enrolled between 20 and 30 participants. 18,19,21 Two trials were limited to male participants only, 19,21 while the other two trials included both men and women. 18,20 A total of 17 females and 67 males were enrolled across the trials reviewed. Age of the enrolled participants was expressed as mean±standard deviation in all trials, 18 –21 whereas two trials also presented an age range, in which the youngest and eldest participant enrolled were 18 and 54, respectively. 18,19 Two studies enrolled athletes, including semicompetitive and competitive cyclists, 19 and elite basketball players. 21 Two trials did not specify level of fitness of physical activity of the cohort other than being apparently healthy. 18,20
Min, minutes; W, watts; RPE, rating of perceived exertion; VO2, volume of oxygen consumption; RPM, revolutions per minute; SBP, systolic blood pressure; DBP, diastolic blood pressure; MBP, mean blood pressure; RPP, rate pressure product; HR, heart rate; RQ; respiratory quotient.
Overview of interventions
Acupuncture conditions
Two types of acupuncture were used in the trials reviewed. One of the trials used EA, 18 and three trials used traditional acupuncture needling. 19 –21 Three trials prescribed acupuncture for 20–30 minutes preexercise only, 18 –20 while one trial retained needles from 15 minutes preexercise until completion of the exercise test. 21
Fourteen acupuncture points were used across the trials reviewed: Baihui DU 20, Jianyu LI 15, Shouwuli LI 13, Neiguan PC 6, Zusanli ST 36, Sanyinjiao SP 6, Shangqui PC 5, Lieque LU 7, Hegu LI 4, Guangming GB 37, Xuanzhong GB 39, Yanglingquan GB 34, Quchi LI 11, and Taichong LR 3. The most common points used were PC 6 and ST 36, with each point being used in three trials. The other twelve sites (i.e., DU 20, LI 15, LI 13, SP 6, PC 5, LU 7, LI 4, GB 37, GB 39, GB 34, LI 11, and LR 3) were not shared across two or more studies. Two studies that utilized manual acupuncture stated the timing and frequency of manipulation. 19,20 One trial involved manipulating the needles once, halfway through the total duration of treatment, for 15–20 seconds per needle, 20 while the other involved manipulating needles every 5 minutes for 1 minute per needle. 19 The study using EA had a set frequency of 2 Hz and a current of 1–2 mA. 18 One trial did not describe the acupuncture manipulation technique that was used. 21
Placebo conditions
Three trials involved a placebo condition. 19 –21 Two trials achieved this by having the acupuncture needles placed and inserted 1–3 cm away from the intervention sites, 20,21 Another trial involved inserting the needles away from the usual sites and using minimal insertion. 19
Control conditions
A no-treatment control condition was included in all four trials. 18 –21
Overview of exercise interventions: Modality, protocol, and termination criteria
All four trials used a cycle ergometer as the exercise modality (Table 1). 18 –21 Two trials applied a ramped protocol in which the intensity of exercise was increased every 1–2 minutes, 18,21 whereas one trial involved a staged exercise protocol in which the intensity was increased every 3 minutes. 20 All three of these trials used volitional fatigue as the termination criteria. 18,20,21 One study enrolling male cyclists involved a 20-km timed trial performed on a cycle ergometer. 19
Outcome measures
Three trials evaluated the effect of acupuncture on exercise performance, 18 –20 while one trial evaluated the effect of acupuncture on postexercise recovery. 21 The outcome measures evaluated in these trials included: HR, RPE, volume of oxygen consumption (VO2), BP, RPP, workload, blood lactate, perception of pain, time to complete a 20-km timed trial, and time to return HR to preexercise (baseline) level (Table 1).
Effect of acupuncture on exercise performance
Li et al. 18 recruited 24 healthy adults who completed four preexercise conditions: (1) EA at PC 5 and PC 6; (2) EA at LU 7 and LI 4; (3) EA at GB 37 and GB 39; and (4) a no-treatment control condition. The trial demonstrated that EA at PC 5 and PC6 and LU 7 and LI 4 significantly reduced exercise-induced increases in mean BP and SBP and RPP versus control. Moreover, treatment at PC 5 and PC 6 and at LU 7 and LI 4 significantly increased peak power output versus control. By contrast, DBP and HR were not significantly different between conditions. Notably, however, Li et al. 18 limited their analyses to participants who were deemed to be responders (∼ 70% of their cohort).
Dhillon 19 also investigated the effect of preexercise acupuncture on exercise performance. Twenty (20) male cyclists completed a 20-km timed trial on a cycle ergometer under three conditions: (1) preexercise acupuncture at ST 36, GB 34, LI 11, LR 3, and DU 20; (2) preexercise placebo (i.e., needles inserted away from acupuncture sites); and (3) control. The investigators determined that RPE at the completion of the exercise protocol was significantly higher in the acupuncture condition versus the placebo and control conditions. However, no other treatment effects were noted. In particular, no effect was noted among conditions on time to complete the 20-km timed trial or the rating of pain or blood lactate concentrations immediately postexercise.
Karvelas et al. 20 evaluated the effect of preexercise acupuncture at DU 20, LI 15, LI 13, PC 6, ST 36, SP 6 versus placebo (i.e., needles inserted away from acupuncture sites) and control conditions in a cohort of 10 healthy adults. Outcome measures, including HR, RPE, and VO2 were not significantly different between conditions at 3, 6, 9, and 12 minutes of the graded exercise test. HR and VO2 at peak exercise intensity were also not significantly different among conditions. 20
Effect of acupuncture on postexercise recovery
Lin et al. 21 evaluated an effect of acupuncture on postexercise recovery. Thirty (30) male athletes were randomly assigned to three conditions: (1) acupuncture; (2) placebo; and (3) control. The acupuncture needles were inserted at PC 6 and at ST 36 15 minutes preexercise and remained inserted during the graded exercise protocol to volitional fatigue. The acupuncture group had significantly reduced HR, VO2, and blood lactate versus the placebo and control groups at 30 minutes postexercise. Blood lactate was also significantly lower in the acupuncture group versus the other two groups at 60 minutes postexercise. No significant changes were noted among the groups at 5 minutes postexercise. Notably, however, the bodily positioning of the participants during the postexercise recovery period (e.g., seated, supine, etc.) was not reported.
Study quality assessment
Study quality assessment was based on the McMaster Critical Review Form for Quantitative Studies 22 with minor adjustments made to accommodate the acute study designs. A summary of the quality assessment is presented in Table 2. The authors of all four studies clearly stated the purposes of their research and reviewed the appropriate background literature, and samples were reasonably well-described, according to age, gender, and health status; however, the authors of the majority of trials did not describe their samples with respect to general body measures (e.g., height, weight, and body mass index), which can confound the exercise response. 18,19 Moreover, only one trial included participants who were acupuncture naïve, 19 whereas the authors of the other trials did not describe the acupuncture experience of their cohorts. Sample-size estimates were computed a priori in only one trial. 18 Outcome measures were generally reliable and valid across all trials. All three within-subjects studies controlled for time of day of repeated assessments. 18 –20 Exercise protocols and acupuncture interventions were described in sufficient detail to ensure replication with the exception of one trial that did not provide any details on acupuncture-needle manipulation. 21 All studies were unable to avoid contamination of results thoroughly through significant blinding of participants to the intervention, and the authors did not disclose if co-interventions, such as medication, massages, acupuncture, or other health/mental strategies were avoided during testing sessions. No studies reported on any potential adverse events caused by the acupuncture treatment. Only one study mentioned that outcome assessors were blinded to the intervention. 20 The findings of all trials were reported in terms of statistical significance. In general, appropriate statistical analyses were used, and the clinical importance of the findings were discussed in accordance with the outcomes. One trial limited statistical analyses to participants who responded favorably to the intervention (∼ 70% of the sample) rather than analysing the total cohort, which could be interpreted as a source of bias, although justification was provided a priori within the study methods. Participant attrition encountered prior to, or during, the testing sessions was not reported in any trial (Table 1).
Discussion
To the current authors' knowledge, this is the first systematic review to investigate the effect of acute acupuncture on exercise performance and postexercise recovery. The literature search identified four unique trials, the findings of which provide only some support for the use of acupuncture as a means of enhancing exercise performance, with only one trial finding a positive effect 18 and two finding no effect. 19,20 In terms of exercise recovery, however, there is preliminary support, as the only trial to date reported a positive finding. 21 Both trials reporting a positive finding 18,21 applied acupuncture at Neiguan (PC 6), whereas only one trial showing a null effect involved applying needles at PC 6. 20 However, this latter trial 20 involved only 10 participants and may have been underpowered. There was also heterogeneity with respect to the design of the acupuncture interventions, with especially regarding duration of the needling.
Enhancement of exercise performance and postexercise recovery may be of benefit to a broad spectrum of individuals, ranging from cohorts of patients with chronic diseases to elite, high-performance athletes. Increased exercise tolerance (i.e., the ability to tolerate higher workloads) within a given exercise session could enhance ongoing, training-induced adaptation, including improvement of health and performance-related fitness variables and amelioration of chronic disease–risk factors. Moreover, expeditious postexercise recovery could be particularly important for athletes who engage in heavy volumes of training, including many sessions per day, whereas people who perform exercise for health-related reasons and for rehabilitation may be able to experience better recovery and fewer exercise-related complications.
The evidence reviewed is preliminary and should be interpreted with caution. Many methodological limitations exist within this body of literature, and many research questions remain to be investigated. Limitations of the trials reviewed were evident with respect to sample sizes, study designs, participant blinding and placebo methods, clinical heterogeneity of the acupuncture interventions, and reporting of pertinent participant characteristics of co-interventions and adverse events. Addressing the shortcomings of these trials in future trials will enable collection of more-accurate and unbiased data.
Three of the four trials reviewed involved a within-subjects, crossover design with randomization. 18 –20 Researchers who plan future studies should be made aware that this type of design increases the likelihood of participants being able to differentiate among interventions, particularly the acupuncture condition and control (no intervention) condition. Although the intention is for participants to be blinded to what they they were receiving (i.e., sham or verum acupuncture), none of the researchers in the reviewed studies actually tested maintenance of blinding. Dissociating results from a placebo effect is an important factor to consider in studies involving acupuncture, given that a placebo effect may account for at least some of the treatment responses to acupuncture. 10,23,24 Therefore, resesearchers involved in future studies should be encouraged to use an RCT design to overcome this important limitation within this field of research.
Only one of the studies reviewed provided justification of the sample size. 18 It is important to conduct statistical analyses to reduce the possibility of committing errors when determining results. Conducting a power analysis in future studies would determine what sample size would be needed to determine the presence of an effect; studies can be underpowered or overpowered in this sense. The sample size in some of the studies could have been too small to produce significant results, which may have been the case in the study by Karvelas et al., 20 in which only 10 participants were enrolled. By contrast, a sample size that is too large might produce too much of an effect and increase the possibility of a Type 2 error.
Three of the studies reviewed involved a placebo condition that was achieved via placing needles 2–3 cm away from acupoints, for example. 19 –21 A placebo involves giving a participant a treatment that does not contain the specific treatment being tested. 24,25 In these cases, the placebo involved needling nonacupuncture points. The literature suggests that any penetration of the skin, even at nonacupoints, can induce physiologic responses, 27 –30 and, on this basis some researchers have argued that placebo acupuncture is not a valid control condition for acupuncture. 31 –33 It is, however, difficult to delineate treatment effects from placebo effects 24 and, as a result, there is some controversy regarding the best control condition for RCTs investigating acupuncture. Researchers involved in future studies should consider carefully which control condition is most appropriate to their particular study designs. Ideally, a study should include both a placebo control and a no-treatment control, so that responses to a verum acupuncture intervention and placebo acupuncture can be compared with each other and with no treatment.
Pertinent participants' characteristics, including previous acupuncture experience, were not well-described in the reviewed studies. 18,20,21 The involvement of participants who have previously experienced acupuncture could have increased the risk of failed blinding in the within-subject crossover trials. The inclusion of acupuncture naïve participants may be a suitable strategy for mitigating such risk, as attempted by Dhillon et al. 19 However, more-rigorous study designs (i.e., parallel-group RCTs) are also required.
All trials failed to report on, and control for, confounding interventions. Medications and nonpharmacologic factors (e.g., other therapies, supplements, diet, sleep patterns, etc.) can potentially alter responses to acupuncture and exercise, and should therefore be monitored. All trials also failed to report on adverse events that may have been caused by acupuncture and/or exercise. Although adverse events are not commonly experienced secondary to acupuncture treatment, 34,35 appropriate documentation within future trials is essential for establishing safety, which could potentially facilitate translation of research into clinical application.
Adequately powered RCTs with thorough and standardized reporting of research methods (e.g., acupuncture and exercise interventions) and outcomes are required to determine, more adequately, the effect of acupuncture methods on exercise performance and recovery. Future investigations should involve appropriate placebo methods and blinding of both participants and outcome assessors. Participant entry and exclusionary criteria should be clearly defined a priori, and the use of co-interventions (i.e., medications, other therapies, etc.) should be documented adequately. Participants with no prior experience with acupuncture should preferably be enrolled, as this will mitigate the risk of participants detecting the placebo condition(s).
Conclusions
This review found only preliminary evidence that acupuncture methods may enhance exercise performance and postexercise recovery. However, many limitations were also identified in the trials conducted to date, and further investigations involving more-rigorous study designs and methods of reporting are required. The potential translation of this research into practice in an attempt to enhance health and performance should remain the overall objective.
Footnotes
Disclosure Statement
The authors declare that they have no competing financial interests.
