Abstract
Pharmacological and chemical probes are foundational tools for asking basic biological and translational questions. They complement genetic strategies, such as CRISPR and RNA interference technologies. Together, these strategies enable biologist and clinician scientist to advance biomedical research and accelerate discovery of the next generation of therapeutics.
This premier special issue of the series focuses
Some of the assays and technologies of interest include: (a) phenotypic, fragment-based or target-based screening for small molecule ligand discovery; (b) high-throughput biochemical, biophysical. And cell-based methods that accelerate probe characterization; (c) chemoproteomic and proteomic methods for probe discovery and validation; (d) computer-based methods if supported by extensive wet-lab follow up. We are also interested in strategies for screening library design and development, as well as advanced assays for target validation.
Special Issue Editors,
Vanderbilt University, School of Medicine, will consider articles from the full breadth of research in the field from original research papers, reviews, and methods papers, to perspectives, profiles, commentaries, and exemplary front matter.
Areas of interest include, but are not limited to: Phenotypic, fragment-based or target-based screening for small molecule ligand discovery High-throughput biochemical, biophysical, and cell-based methods that accelerate probe characterization Chemoproteomic and proteomic methods for probe discovery and validation Computer-based methods, if supported by extensive wet-lab follow up
Contributions will receive prompt and thorough peer review, feedback, and decision. Please refer to our
Editorial or technical questions?
Contact Taylor Bowen (