Call for Special Issue Papers: Chemical Probes and Pharmacological Tools for Kinase Signaling

Pharmacological and chemical probes are foundational tools for asking basic biological and translational questions. They complement genetic strategies, such as CRISPR and RNA interference technologies. Together, these strategies enable biologist and clinician scientist to advance biomedical research and accelerate discovery of the next generation of therapeutics.

This special issue focuses on chemical probes and pharmacological tools (CPPT) that target kinases. We encourage reports of kinase-targeted inhibitor and degrader molecules development and validation; studies of SAR for novel and existing kinase pharmacological tools; work that invalidates previously reported tools or describes new insights into systems and conditions that need to be taken into account when using a specific tool; development of assays to characterize small molecules across the kinome, both those aimed at selectivity profiling as well as those that measure proteomic/signaling effects of kinase inhibition; and developing tools and assays for visualization of kinase signaling networks and how they respond to genetic and/or small molecule perturbations. Moreover, studies that address questions related to polypharmacological effects, especially when accompanied by method and assay development work are also of interest. Work on non-human kinases (such as microbial kinases) would also be considered if addresses an important aspect of kinase CPPT development and validation.

Special Issue Editors, Milka Kostic, PhD, Dana-Farber Cancer Institute, and Bruce J. Melancon, PhD, Vanderbilt University, School of Medicine, will consider articles from the full breadth of research in the field from original research papers, reviews, and methods papers, to perspectives, profiles, commentaries, and exemplary front matter.

Areas of interest include, but are not limited to:

Kinase-targeted inhibitor and degrader molecules development and validation

Studies of SAR for novel and/or existing kinase-targeted pharmacological tools

Use cases that describe new systems and/or conditions for using existing tools, or invalidate the tool in a given context

Assays for developing and screening kinase

Assay development for studying kinase signaling, including imaging tools and probes, and probes for understudies kinases

Contributions will receive prompt and thorough peer review, feedback, and decision. Please refer to our Instructions for Authors before submitting your manuscript for consideration. Authors are encouraged to evaluate ideas directly with Milka Kostic, PhD (Milka_Kostic@DFCI.HARVARD.EDU).

ASSAY and Drug Development Technologies provides access to novel techniques and robust tools that enable critical advances in early-stage screening. This research published in the Journal leads to important therapeutics and platforms for drug discovery and development. This reputable peer-reviewed journal features original papers application-oriented technology reviews, topical issues on novel and burgeoning areas of research, and reports in methodology and technology application. Please visit our website at www.liebertpub.com/adt to view our Information for Authors.

Editorial or technical questions?

Contact Taylor Bowen (assay_eo@liebertpub.com)

Visit the Instructions for Authors: www.liebertpub.com/adt

Submit your paper for peer review online: https://mc.manuscriptcentral.com/assay