Correction to: Assessing Experimental Uncertainty in Defined Approaches: Borderline Ranges for In Chemico and In Vitro Skin Sensitization Methods Determined from Ring Trial Data,by Kolle,et al. Appl In Vitro Toxicol 2021;7(3):102–111;doi: 10.1089/aivt.2021.0003

In the September 2021 issue of Applied In Vitro Toxicology (vol. 7, no. 3; 102–111), the article titled Assessing Experimental Uncertainty in Defined Approaches: Borderline Ranges for In Chemico and In Vitro Skin Sensitization Methods Determined from Ring Trial Data, by Kolle et al. requires three corrections.

In the original article, three formulas under the Statistics section appeared as:

The borderline range for an individual laboratory m participating in the ring trial (m = 1, … 7) round the prediction model's cutoff is then determined as follows (after exponentiation of the MADs for transformation to the assays' readout scale):

The number m of participating laboratories in the ring trials was 3 for the DPRA, 7 for the kDPRA, 5 for the KeratinoSens, 5 for the LuSens, and 4 for the h-CLAT, respectively. After the borderline range had been determined for the individual laboratories, the mean and median of the individual lower and upper ranges were determined for all laboratories. The mean of these values is then proposed as a borderline range to be used, as for example, now implemented in the OECD DA guideline¹² and the update of OECD TG 442C to include the kDPRA.¹⁹

It should have appeared as:

The borderline range for an individual laboratory m participating in the ring trial (m = 1, … 7) round the prediction model's cutoff is then determined as follows (after exponentiation of the MADs for transformation to the assays' readout scale):

The number m of participating laboratories in the ring trials was 3 for the DPRA, 7 for the kDPRA, 5 for the KeratinoSens, 5 for the LuSens, and 4 for the h-CLAT, respectively. After the borderline range had been determined for the individual laboratories, the mean and median of the individual lower and upper ranges were determined for all laboratories. The mean of these values is then proposed as a borderline range to be used, as for example, now implemented in the OECD DA guideline¹² and the update of OECD TG 442C to include the kDPRA.¹⁹

The online version has been corrected to reflect this. The authors apologize for this error.