Abstract
Objectives:
It has been proposed that the first step towards a closed-loop artificial pancreas might be to use a continuous glucose sensor to automatically suspend the basal insulin delivery based on projected low sensor glucose values.
Methods:
We reviewed our recent experience with an artificial pancreas system, utilizing a proportional-integrative-derivative (PID) algorithm, in 17 adolescents with type 1 diabetes (T1D) to assess the safety and efficacy of this maneuver.
Results:
During 34 h of closed-loop automated insulin delivery, 18 pump suspensions ≥60 min (90 ± 18 min) occurred in eight subjects. Sensor glucose levels fell from 159 ± 42 mg/dL to a nadir of 72 ± 13 mg/dL. Corresponding plasma glucose levels fell from 168 ± 51 to 72 ± 16 mg/dL, with values <60 mg/dL recorded in only four of the 18 events.
Conclusions:
These data suggest that automatic pump suspension using the PID algorithm may be an effective means to prevent hypoglycemia in youth with T1D.