Selection by immunohistochemical and cell cloning.
Heavy and Light Chains of Immunoglobulin
N/A.
Specificity
MG7 is a gastric cancer–specific MAb with high specificity and sensitivity. By using MG7 MAb, we found that MG7Ag was increasingly detected in superficial gastritis, atrophic gastritis, intestinal metaplasia, atypical hyperplasia, and gastric cancer, indicating that MG7Ag could be considered an important early warning molecule of gastric cancer and MG7 MAb could be used as a tool for screening gastric cancer.(1,2)
Specific Antigen Identified
Human heterogeneous nuclear ribonucleoprotein A2/B1 hnRNP A2/B1.3
Availability
Tissue culture supernatant
Yes
✓
No
Ascitic fluid
Yes
✓
No
Hybridoma cells
Yes
✓
No
References
1.
FanDM, ZhangXY, ChenXT, MuZX, HuJL, QiaoTD, ChenBJ. Mouse and human monoclonal antibodies against gastric cancer. Preparation and clinical application. Chin Med J, 1988; 101:488–489.
2.
LiuJ, HuJL, ZhangXY, QiaoTD, ChenXT, WuKC, DingJ, FanDM. The value of MG7Ag in predicting cancerous change in dysplastic gastric mucosa. Int J Clin Pract, 2002; 56:169–172.
3.
LeeCH, LumJH, CheungP, WongMS, ButtYK, TamMF, ChanWY, ChowC, HuiPK, KwokFS, LoSC, FanDM. Identification of the heterogeneous nuclear ribonucleoprotein A2/B1 as the antigen for the gastrointestinal cancer specific monoclonal antibody MG7. Proteomics, 2005; 5:1160–1166.
