Testing a Possible Cocataractogenic Potential of Befunolol (Glauconex R ) with Animal Cataract Models

ABSTRACT

Befunolol was tested in an animal experiment with 2 cataract models of the Sprague-Dawley-rat. The treatment scheme was designed with 8 different treatment groups, such that befunolol could be tested single and in combination with one or two cataract models. Over the 6 weeks experimental period, slit lamp microscopy and Scheimpflug photography were employed as observation and documentation methods, extensive post-mortem biochemistry was carried out after sacrifice of the animals. Neither the in-vivo observation and documentation nor the biochemistry showed pronounced effects pointing to a cocataractogenic potential of the drug. Slit density enhancing effects were found in combining UV-B irradiation and befunolol treatment. This effect has also been found in other experiments with timolol.