Abstract
Biomaterials are employed for the repair, replacement, and regeneration of diseased or damaged tissues or organs. Nevertheless, their clinical success is still limited. The major limitation of available biomaterials is that their basic design does not simultaneously fulfill complex requirements such as regenerative capacity, mechanical stability, and clinical handling. In view of this, there is a strong demand for new and innovative biomaterials that can satisfy these often conflicting requirements.
The conventional approach to development of biomaterials is the top-down approach. In contrast, a bottom-up approach allows for superior control over the properties of the biomaterials and can enable the production of novel biomaterials with unprecedented features for applications in tissue regeneration. Recently, expanded use of fabrication methods such as 3D printing and electric-field-assisted techniques has opened up new avenues for bottom-up fabrication of tissue-regenerative biomaterial constructs. However, tremendous challenges remain to be overcome towards the development of the ideal tissue-regenerative biomaterials. These challenges concern not only the methods used for their fabrication, but also the methods used for their mechanical, physico-chemical and biological characterization.
This special issue on New Strategies in Biomaterials Design for Tissue Regeneration is dedicated to the development of novel methodologies for synthesis, fabrication, and characterization of tissue-regenerative biomaterials. We invite submission of articles from the full breadth of evidence: from original methods papers and reviews, to perspectives, opinions, commentaries, and exemplary front matter.
Areas of interest include, but are not limited to:
Novel bottom-up strategies for biomaterials design Mechanistic insight and modelling of novel biomaterials Mechanical robustness of novel biomaterials New characterization techniques for evaluation of regenerative biomaterials In vitro assessment of the tissue-regenerative capacity of novel biomaterials In vivo evaluation of the tissue-regenerative capacity of novel biomaterials
We also encourage submission of papers that have been published in conference proceedings, with the requirement that the authors have made significant extensions as compared to the already published version of the study.
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