Abstract
US 2010/0143346 A1 Patent application Published 10 Jun 2010
Treatment of Macular Degeneration
Inventors/Applicants
An agent having progesterone antagonist properties may be used to treat eye conditions associated with pathological blood vessel formation, for example, age-related macular degeneration, choroidal neovascularization, retinal neovascularization, or corneal neovascularization. The agent may be mifepristone.
WO 2010/060934 A2 Patent application Published 3 Jun 2010
CNNM Proteins and Uses Thereof
Inventors/Applicants
The present invention relates proteins from the group consisting of CNNM1, CNNM2, CNNM3, and CNNM4, its derivatives, or fragments thereof for use as a medicament, for treatment, and/or for diagnostic purposes. The invention further relates to a human genomic DNA, cDNA, or mRNA sequence encoding for a functional protein chosen from the group consisting of CNNM1, CNNM2, CNNM3, and CNNM4 and functional derivatives or fragments thereof.
WO 2010/059598 A1 Patent application Published 27 May 2010
Methods for Producing Fish with High Lipid Content
Inventors/Applicants
The invention provides methods for producing biofuel from algae that use fish that have a high capacity of producing and/or accumulating lipids to harvest algae from an algal culture. The invention also provides methods for growing fish that result in a high lipid content. The invention also provides methods for creating fish that have a high capacity of producing and accumulating lipids by breeding and/or recombinant DNA techniques. Also included are transgenic fish that have higher lipid content than wild-type fish.
US 7713925 Granted patent Published 11 May 2010
Syndecans and Angiogenesis
Inventors/Applicants
The invention provides methods and materials related to modulating syndecan levels and angiogenesis in an animal. The invention provides syndecan polypeptides and nucleic acids encoding syndecan polypeptides, including dominant negative syndecan polypeptides. The invention also provides polynucleotides and polynucleotide analogs for modulating angiogenesis, as well as cells and embryos containing the polynucleotides and polynucleotide analogs. The invention further provides methods for identifying syndecan- and angiogenesis-modulating agents.
WO 2010/049688 A1 Patent application Published 6 May 2010
Leukolectins and Uses Thereof
Inventors/Applicants
The present invention relates to a polypeptide, described as a lectin, its encoding nucleic acid sequence, and antibodies to the polypeptide and their use in various medical applications, particularly for treating or preventing an autoimmune disorder, an inflammatory disorder, or damaged skin in an animal.
US 2010/0104203 A1 Patent application Published 29 Apr 2010
Method and Apparatus for Acquisition, Compression, and Characterization of Spatiotemporal Signals
Inventors/Applicants
The present invention provides methods and apparatus for acquisition, compression, and characterization of spatiotemporal signals. In one aspect, the invention assesses self-similarity over the entire length of a spatiotemporal signal, as well as on a moving attention window, to provide cost-effective measurement and quantification of dynamic processes. The invention also provides methods and apparatus for measuring self-similarity in spatiotemporal signals to characterize, adaptively control acquisition and/or storage, and assign metadata for further detail processing. In some embodiments, the invention provides for an apparatus adapted for the characterization of biological units, and methods by which attributes of the biological units can be monitored in response to the addition or removal of manipulations, for example, treatments. The attributes of biological units can be used to characterize the effects of the abovementioned manipulations or treatments as well as to identify genes or proteins responsible for, or contributing to, these effects.
US 2010/0105140 A1 Patent application Published 29 Apr 2010
Plaice DNA Transposon System
Inventors/Applicants
This document describes the Passport transposon system and methods of making and using the same.
US 2010/0086532 A1 Patent application Published 8 Apr 2010
Chimeric Zinc Finger Recombinases Optimized for Catalysis by Directed Evolution
Inventors/Applicants
The present invention is directed to chimeric recombinases comprising a serine recombinase operatively linked to a zinc finger nucleotide binding domain such that the chimeric recombinase protein catalyzes site-specific recombination at a DNA site specifically bound by the zinc finger nucleotide binding domain. The serine recombinase can be one of several naturally occurring serine recombinases. The invention also includes nucleic acids encoding the chimeric recombinases, vectors including the nucleic acids, host cells transformed or transfected with the vectors, methods of using the chimeric recombinases to carry out recombination, methods of using substrate-linked protein evolution to generate additional chimeric recombinases, methods of using the chimeric recombinases for gene therapy, and pharmaceutical compositions.
Footnotes
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