High-frequency ventilation is a general term that refers to a family of ventilator techniques that utilize respirator rates greater than 60 breaths/minute and tidal volumes that are usually less than or equal to the anatomical dead space of the airways. These techniques include high frequency positive-pressure ventilation, high frequency jet ventilation, high frequency flow interruption, high frequency oscillatory ventilation, and high frequency chest wall oscillation. I review the proposed mechanisms of gas transport during high-frequency ventilation and the different ventilators capable of delivering this mode of ventilation. In addition, clinical studies involving infants treated with this new technology are reviewed, along with long-term patient follow-up and reported complications.
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