Using hydroxyethyl starch (HES) 130/0.42 instead of crystalloid for fluid resuscitation of adult intensive care patients with severe sepsis increases mortality.
Level of evidence: 1B (RCT with narrow confidence intervals)
References
1.
ShortgenFLacheradeJCBruneelF. Effects of hydroxyethylstarch and gelatin on renal function in severe sepsis: a multicentre randomised study. Lancet2001;357: 911–16.
2.
BrunkhorstFMEngelCBloosF. Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med2008;358: 125–39.
3.
ReinhartKPernerASprungCL. European Society of Intensive Care Medicine. Consensus statement of the ESICM task force on colloid volume therapy in critically ill patients. Intensive Care Med2012;38: 368–83.
