Multiple sclerosis epidemiology in Latin America: An updated survey

Abstract

Novel epidemiological data have appeared in recent years in Latin America (LATAM). The objective of this study was to perform an updated systematic review of the epidemiology of the disease reported in LATAM.

Methods

We conducted a systematic review of published epidemiological articles from January 1995 to December 2016.

Results

Incidence data were found in four studies and ranged from 0.3 to 3 annual cases per 100,000 person-years. Prevalence was reported in 13 studies and ranged from 0.83 to 38.2 cases per 100,000 inhabitants. Two studies showed an increase in prevalence and incidence in the last five years in specific regions.

Conclusion

The study provides updated information on epidemiological features of MS in the region. The frequency reported is lower compared with some European and North American countries; however, due to recent observations, studies including follow-up assessment of prevalence and incidence should be conducted in the region.

Keywords

Multiple sclerosis Latin America epidemiology incidence prevalence

Introduction

Systematic study of multiple sclerosis (MS) in populations started in 1929 when 40 cases in North Wales were ascertained, estimating a point prevalence of 13 per 100,000 inhabitants.¹ Today, there are several publications that deal with prevalence and incidence of MS throughout the world; nonetheless, despite this wealth of data, current knowledge of MS epidemiology in Latin America (LATAM) is limited.^2–5

An uneven distribution of MS in LATAM was described.³ LATAM presents different population genetics and environmental aspects around the region, with European and African immigrants resulted in a concentration of the Caucasian population in the southern regions of the continent whereas in the northern region, the population is predominately Mestizo.⁶ In terms of epidemiological observations in the region,^3,7 information regarding incidence, prevalence and other aspects were described and allowed us to understand and compare the disease in LATAM with other regions of the world; however, novel data have appeared over the last few years that make the updating of the information about the frequency of the disease in our region relevant in order to better understand the distribution of the disease.

Considering that the distribution of MS has substantial differences in LATAM regarding other world regions and that novel epidemiological data emerged during the last years, the objectives of the present study were to perform an updated systematic review of the epidemiology of the disease reported in LATAM and discuss the findings.

Material and methods

Search strategy and selection criteria

We conducted a systematic non-language-restricted literature search of LATAM MS reports from January 1995 to December 2016 using electronic databases included in Cochrane CENTRAL, MEDLINE, EMBASE, and LILACS with the following search terms:

multiple sclerosis and Latin America

multiple sclerosis and population*

multiple sclerosis and epidemiology

multiple sclerosis and prevalence

multiple sclerosis and incidence

multiple sclerosis and etiology*

Selection criteria

The review was restricted to published research articles in order to perform a complete evaluation of the quality of the studies included in our review (setting, type of study, study population, deﬁnition of MS, prevalence and incidence rate, and 95% conﬁdence interval). Population-based studies were included if data were collected through standardized questionnaires, if raw population numbers were available for data conﬁrmation and if MS was diagnosed, based on validated diagnostic criteria.^8–11 We also included studies involving a network of hospitals that fulﬁlled previous criteria. Studies that were based in a single institution or did not involve a network of hospitals serving a well-deﬁned general population were excluded.

Data extraction and assessment of study quality

Two of the authors agreed on the data to be extracted. Data included the study period, details of the study population and diagnostic selection criteria. One of the reviewers (JIR) extracted data using a data extraction form, while a second reviewer (EC) conﬁrmed the data. Each study was evaluated on the following items: type of study design; description of study population; and adequacy of case deﬁnition based on validated criteria.^8–11 Those studies in which the items were not reported or unclear were excluded.

Assessment of risk of bias

Methodological quality used in the reviewed studies and risk of bias was assessed by two reviewers using a modified checklist available in Strengthening the Reporting of Observational studies in Epidemiology (STROBE)¹² and in Fowkes and Fulton.¹³ We estimated a bias risk summary considering six criteria: methods for selecting study participants, methods for measuring exposure and outcome variables, methods to control confounding, design-specific sources of bias, comparability among groups and statistical methods and declaration of conflicts of interest.

Results

A total of 645 citations were identified. After reviewing titles and abstracts, 65 studies were considered eligible. After full-text review, 14 met inclusion criteria and were selected for data abstraction and analysis of incidence-prevalence (Figure 1).^14–37 Information was obtained from nine countries (Figure 2). Regarding incidence, we found five studies (French West Indies, Argentina and Panama) that evaluated this issue.^16,19,24,38 Of these five studies, one reported incidence from a period of 16 years that was later extended to 22 years. This study identified an increase in incidence during the follow-up period.³⁸ Incidence values ranged from 0.15 to 3 annual cases per 100,000 person-years (Table 1). Regarding prevalence rates, 13 identified studies assessed prevalence in the region (Table 2). Reported prevalence ranged from 0.75 to 38.2 cases per 100,000 inhabitants (Table 2). The reported prevalence was lower in Ecuador, Colombia and Panama (range = 0.75 to 6.5 cases per 100,000 inhabitants) while Brazil and Argentina reported 12 to 38.2 cases per 100,000 inhabitants.

Figure 1.

Flow of studies through the review.

Figure 2.

City-country multiple sclerosis prevalence reported in the studies included in the review.

Table 1.

Reported multiple sclerosis (MS) incidence in Latin America and the Caribbean.

Author/year	City/country latitude	Number of MS patients (numerator)	Population of origin (denominator)	Incidence reported per 100,000 persons-year (95% CI)
Cabre 2005	West French Indies 14° 30′, N	47	683,000	1.4 (1–1.8)
Cabre 2005	Martinique West French Indies 14° 30′, N	35	343,000	1.9 (1.2–2.6)
Cabre 2005	Guadalupe West French indies 14° 30′, N	12	340,000	0.6 (0.3–0.9)
Gracia 2009 (period 1990–1999)	Panama Panama City 7°12′07′′	65	3,228,186	0.3 (0.15–0.4)
Gracia 2009 (period 2000–2005)	Panama Panama City 7°12′07′′	79	3,228,186	0.51 (0.28–0.61)
Cristiano 2010	Buenos Aires Argentina 34° S	18	145,000	1.76 (1.1–2.8)
Cristiano 2016	Buenos Aires Argentina 34° S	42	165,456	3 (2.1–3.5)

CI: confidence interval; N: north; S: south.

Table 2.

Reported multiple sclerosis (MS) prevalence in Latin America and the Caribbean.

Author/year	City/country	Number of people with MS (numerator)	Population of origin (denominator)	Prevalence reported per 100,000 inhabitants (95% CI)
Sánchez 2000^a	Colombia Risaralda	45	903,924	4.98 (3.52–6.43)
	Colombia Santander	48	1,900,121	2.53 (1.81–3.24)
	Colombia Caldas	17	1,074,856	1.58 (0.83–2.33)
Colombia Antioquia	75	5,182,839	1.48 (1.12–1.78)
Callegaro 2001	São Pablo Brazil	1483	10,114,632	15 (13.9–15.4)^b
Cabre 2005	West French Indies	101	683,000	14.8 (11.9–17.7)
Cabre 2005	West French Indies Martinique	72	343,000	21 (16.1–25.9)
West French Indies Guadalupe	29	340,000	8.5 (5.4–11.6)
Fragoso 2007	Santos Brazil	65	418,316	15.54 (12–19.8)^b
Toro 2007	Colombia Bogotá	296	6,712,247	4.41 (3.9–4.9)
Melcon 2008	Argentina Patagonia	72	417,666	17.2 (13.7–21.7)^b
Cristiano 2009^a	Buenos Aires Argentina	1833	12,594,974	17.8 (14–19.8)
Gracia 2009	Panama Panama City	193	3,228,186	5,24 (4.49–6.07)
Vizcarra 2009	Peru Lima	616	8,005,778	7.69 (7.03–8.3)
Abad 2010	Quito Ecuador	103	2,036,260	5.05 (4.03–6.03)
Abad 2010	Cuenca Ecuador	50	2,206,213	2.26 (1.62–2.91)
Guayaquil Ecuador	5	666,085	0.75 (0.024–0.175)
Ribeiro et al. 2011	Uberaba, Brazil	35	295,988	12.5 (8.7–17.4)
Lana-Peixoto et al. 2012	Belo Horizonte, Brazil	409	19,597,330	18.1 (16.4–19.9)
Cristiano 2016^a	Buenos Aires Argentina	4901	12,806,866	38.2 (36.1–41.2)

Studies used capture-recapture method to estimate global prevalence. Cases included were adjusted cases.

95% CI not reported in the original publication.

CI: confidence interval.

Discussion

During the last decade, there has been a surge of interest in the epidemiology of MS in LATAM, and several investigations have begun to provide a reasonable estimate of the disease in the region. In this updated review of the frequency of MS in LATAM, we found that the incidence reported ranged from 0.15 to 3 cases per 100,000 person-years. Prevalence ranged from 0.75 to 38.2 cases per 100,000 inhabitants in 13 studies analyzed.

Reported prevalence and incidence of MS in the region were substantially lower than data found in developed countries, even we observed significant differences between countries from LATAM.⁶ Reasons for these differences were attributed to certain environmental and genetic factors.^39,40 The distribution of population genetics in LATAM could account for the observed differences. As previously mentioned, a complex mixture between Andean natives with European and African immigrants resulted in a concentration of the Caucasian population in the southern regions of the continent whereas in Colombia and the northern region, the population is predominately Mestizo.⁶ It is possible that the Caucasian population has a higher risk of MS than the non-Caucasian population as previously described. Risco et al. found a continental South-North gradient in LATAM between Panama and Argentina; however, they did not find a clear trend of increasing MS prevalence and latitude within Colombia, Ecuador or Argentina, suggesting that other human factors such as ethnicity play an important role in determining the geographic distribution of MS regardless of the impact of latitude.⁶ Cabre et al. evaluated the role of migration in the frequency of the disease in French West Indies.⁴¹ They found that the prevalence of MS was twice as high in Caucasian migrants as in non-migrants and that the prevalence was very high if this stay in a temperate region occurred before the age of 15 years.⁴¹ A clear dose-response relationship between the duration of residence out of the French West Indies and the prevalence of MS was also found. A possible explanation provided by authors was that migration of Caucasian genes into the Afro-Caribbean population could serve as a vector for the introduction in the French West Indies of possible infectious environmental factors operating, in particular, before the age of 15 years. These environmental changes may either trigger or protect from the disease.⁴¹ Those findings were in line with other studies of Caucasian populations migrating from high-prevalence areas to low-prevalence areas, suggesting that the risk of acquiring the disease is determined before the age of 15 years (for populations from the United Kingdom who emigrated to South Africa⁴² and for Jewish populations emigrating to Israel, for example⁴³). It is important to mention that prevalence is not, however, the best epidemiological instrument for evaluating the change in risk induced by migration.

Interestingly, in the updated information gathered we found two studies that described an increase in prevalence of MS after 20 years as well as an increase in incidence of MS during follow-up, mainly in females. These findings are in line with previous studies performed in other regions of the world that showed an increase in MS incidence and prevalence.^44–46 Hirst et al. in South East Wales displays an increase of 45% in the prevalence of MS, from 101 to 146 per 100,000 population over 20 years,⁴⁷ while Svenningsson et al. in 2015 published research performed in Vasterbotten County, Sweden, in which a significant increase in the prevalence of MS over a period of 10 years was observed (from 188 to 215 per 100,000 inhabitants).⁴⁸ Fernández et al. reported in 2012 a prevalence of MS in Malaga, Spain, by using the capture-recapture method of 125 per 100,000 inhabitants, higher than previously published in the region.⁴⁹

The other possible cause related to the low frequency and uneven distribution of the disease in the region could be attributed to environmental factors. As latitude increases, the intensity and duration of sunlight decrease. Many studies have suggested that a lower exposure to sunlight in high latitudes is associated with a greater risk of MS.^39,50 This may explain the increased risk observed in areas located at a greater distance from the equator. Also, it has been proposed that improved hygiene, which partially explains the reduced rate of infections in Western countries, might be a starting point to clarify the increased incidence of allergic and autoimmune diseases in a northern hemisphere population.⁵¹ Several factors could contribute to the so-called hygiene hypothesis;⁵¹ however, this social effect is observed in many areas of LATAM and could be a factor involved in the low prevalence of autoimmune diseases observed in the region.⁵² Finally, subdiagnosis may contribute to underestimating the MS prevalence found in LATAM.³ This situation occurs in several regions of the world and may be a factor in LATAM as well.

MS remains a complex disease that is likely caused by the interplay of still unknown genetic and environmental factors. Further efforts are required to determine the exact interplay between environmental factors, lifestyle modifications and genetic susceptibility.³⁹

In summary, this study provides updated information on epidemiological features of MS in the region, including incidence and prevalence. An increase in frequency should appear in the region, as shown by recent research; however, future studies including follow-up assessment of prevalence and incidence should be conducted in the region.

Footnotes

Conflicts of interest

None declared.

Funding

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

References

Allison

. Disseminated sclerosis in North Wales: An inquiry into its incidence, frequency, distribution and other etiological factors. Brain 1931; 53: 391–430.

Cristiano

Patrucco

Rojas

. A systematic review of the epidemiology of multiple sclerosis in South America. Eur J Neurol 2008; 15: 1273–1278.

Cristiano

Rojas

Romano

. The epidemiology of multiple sclerosis in Latin America and the Caribbean: A systematic review. Mult Scler 2013; 19: 844–854.

Kurtzke

. Epidemiology of multiple sclerosis. Does this really point toward an etiology? Lectio Doctoralis. Neurol Sci 2000; 21: 383–403.

Kurtzke

. Epidemiology and etiology of multiple sclerosis. Phys Med Rehabil Clin N Am 2005; 16: 327–349.

Risco

Maldonado

Luna

. Latitudinal prevalence gradient of multiple sclerosis in Latin America. Mult Scler 2011; 17: 1055–1059.

da Gama Pereira

Sampaio Lacativa

da Costa Pereira

. Prevalence of multiple sclerosis in Brazil: A systematic review. Mult Scler Relat Disord 2015; 4: 572–579.

Polman

Reingold

Banwell

. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol 2011; 69: 292–302.

Polman

Reingold

Edan

. Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria”. Ann Neurol 2005; 58: 840–846.

10.

McDonald

Compston

Edan

. Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol 2001; 50: 121–127.

11.

Poser

Paty

Scheinberg

. New diagnostic criteria for multiple sclerosis: Guidelines for research protocols. Ann Neurol 1983; 13: 227–231.

12.

von Elm

Altman

Egger

. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: Guidelines for reporting observational studies. Lancet 2007; 370: 1453–1457.

13.

Fowkes FG and Fulton PM. Critical appraisal of published research: introductory guidelines. BMJ 1991; 302: 1136–1140.

14.

Callegaro

Goldbaum

Morais

. The prevalence of multiple sclerosis in the city of São Paulo, Brazil, 1997. Acta Neurol Scand 2001; 104: 208–213.

15.

Abad

Pérez

Castro

. Prevalence of multiple sclerosis in Ecuador [article in Spanish] Prevalencia de esclerosis multiple en Ecuador. Neurologia 2010; 25: 309–313.

16.

Cabre

Signate

Olindo

. Role of return migration in the emergence of multiple sclerosis in the French West Indies. Brain 2005; 128: 2899–2910.

17.

Cristiano

Patrucco

Rojas

. Prevalence of multiple sclerosis in Buenos Aires, Argentina using the capture-recapture method. Eur J Neurol 2009; 16: 183–187.

18.

Fragoso

Peres

. Prevalence of multiple sclerosis in the city of Santos, SP. Rev Bras Epidemiol 2007; 10: 479–482.

19.

Gracia

Castillo

Benzadón

. Prevalence and incidence of multiple sclerosis in Panama (2000–2005). Neuroepidemiology 2009; 32: 287–293.

20.

Melcon

Gold

Carrá

. Argentine Patagonia: Prevalence and clinical features of multiple sclerosis. Mult Scler 2008; 14: 656–662.

21.

Sánchez

Aguirre

Arcos-Burgos

. Prevalence of multiple sclerosis in Colombia [article in Spanish] Prevalencia de la esclerosis multiple en Colombia. Rev Neurol 2000; 31: 1101–1103.

22.

Toro

Sarmiento

Díaz del Castillo

. Prevalence of multiple sclerosis in Bogotá, Colombia. Neuroepidemiology 2007; 28: 33–38.

23.

Vizcarra Escobar

Kawano Castillo

Castañeda Barba

. Prevalencia de esclerosis múltiple en Lima-Perú. Rev Méd Hered 2009; 20: 146–150.

24.

Cristiano

Patrucco

Giunta

. Incidence of multiple sclerosis in Buenos Aires: A 16-year health maintenance organization-based study. Eur J Neurol 2010; 17: 479–482.

25.

Cabrera-Gómez

Santana

Vals

. Clinical characteristics of patients with multiple sclerosis defined in Cuba [article in Spanish] Caracterización clinica de pacientes con esclerosis múltiple definida en Cuba. Rev Neurol 1998; 26: 723–728.

26.

Cabrera-Gómez

López-Saura

. Alpha interferon in the treatment of multiple sclerosis. Update and experience in Cuba [article in Spanish]. Rev Neurol 1999; 28: 849–858.

27.

Sánchez

Palacio

Uribe

. Clinical features of multiple sclerosis in a genetically homogeneous tropical population. Mult Scler 2001; 7: 227–229.

28.

Alves-Leon

Malfetano

Pimentel

. Multiple sclerosis outcome and morbi-mortality of a Brazilian cohort patients. Arq Neuropsiquiatr 2008; 66: 671–677.

29.

Arruda

Scola

Teive

. Multiple sclerosis: Report on 200 cases from Curitiba, Southern Brazil and comparison with other Brazilian series. Arq Neuropsiquiatr 2001; 59: 165–170.

30.

Ferreira

Machado

Vilela

. Epidemiology of 118 cases of multiple sclerosis after 15 years of follow-up on the reference center of Hospital da Restauracao, Recife, Pernambuco, Brazil. [article in Portuguese] Epidemiologia de 118 de casos de esclorose multipla com seguimento de 15 anos no centro de referencia do Hospital da Restauracao de Pernambuco. Arq Neuropsiquiatr 2004; 62: 1027–1032.

31.

Cardoso

Fukuda

Pereira

. Clinical and epidemiological profile of multiple sclerosis in a reference center in the State of Bahia, Brazil. Arq Neuropsiquiatr 2006; 64: 727–730.

32.

Cordova

Vargas

Sotelo

. Western and Asian features of multiple sclerosis in Mexican Mestizos. Clin Neurol Neurosurg 2007; 109: 146–151.

33.

Finkelsztejn

Cristovam Rdo

Moraes

. Clinical features of multiple sclerosis in the south of Brazil: A partial analysis. Arq neuropsiquiatr 2009; 67: 1071–1075.

34.

Moreira

Felipe

Mendes

. Esclerose múltipla: Estudo descritivo de suas formas clínicas em 302 casos. Arq neuropsiquiatr 2000; 58: 460–466.

35.

Velázquez-Quintana

Macías-Islas

Rivera-Olmos

. Multiple sclerosis in Mexico: A multicentre study [article in Spanish]. Rev Neurol 2003; 36: 1019–1022.

36.

Ferreira

MLB

Machado

MíM

Vilela

. Epidemiologia de 118 casos de esclerose múltipla com seguimento de 15 anos no centro de referência do Hospital da Restauração de Pernambuco. Arq neuropsiquiatr 2004; 62: 1027–1032.

37.

Cristiano

Patrucco

Miguez

. Increasing prevalence of multiple sclerosis in Buenos Aires, Argentina. Mult Scler Relat Dis 2016; 9: 91–94.

38.

Cristiano

Patrucco

Miguez

. Increasing incidence of multiple sclerosis among women in Buenos Aires: A 22 year health maintenance organization based study. Neurol Sci 2016; 37: 1621–1626.

39.

Ebers

. Environmental factors and multiple sclerosis. Lancet Neurol 2008; 7: 268–277.

40.

Ascherio

Munger

. Environmental risk factors for multiple sclerosis. Part II: Noninfectious factors. Ann Neurol 2007; 61: 504–513.

41.

Cabre

Signate

Olindo

. Role of return migration in the emergence of multiple sclerosis in the French West Indies. Brain 2005; 128: 2899–2910.

42.

Dean

Kurtzke

. On the risk of multiple sclerosis according to age at immigration to South Africa. Br Med J 1971; 3: 725–729.

43.

Alter

Kahana Loewenson

. Migration and risk of multiple sclerosis. Neurology 1978; 28: 1089–1093.

44.

Sellner

Kraus

Awad

. The increasing incidence and prevalence of female multiple sclerosis—a critical analysis of potential environmental factors. Autoimmun Rev 2011; 10: 495–502.

45.

Debouverie

Pittion-Vouyovitch

Louis

. Increasing incidence of multiple sclerosis among women in Lorraine, Eastern France. Mult Scler 2007; 13: 962–967.

46.

Vukusic

Van Bockstael

Gosselin

. Regional variations in the prevalence of multiple sclerosis in French farmers. J Neurol Neurosurg Psychiatry 2007; 78: 707–709.

47.

Hirst

Ingram

Pickersgill

. Increasing prevalence and incidence of multiple sclerosis in South East Wales. J Neurol Neurosurg Psychiatry 2009; 80: 386–391.

48.

Svenningsson

Salzer

Vågberg

. Increasing prevalence of multiple sclerosis in Vasterbotten County of Sweden. Acta Neurol Scand 2015; 132: 389–394.

49.

Fernández

Guerrero

. Multiple sclerosis prevalence in Malaga, Southern Spain estimated by the capture-recapture method. Mult Scler 2012; 18: 372–376.

50.

Ascherio

Munger

. Environmental risk factors for multiple sclerosis. Part I: The role of infection. Ann Neurol 2007; 61: 288–299.

51.

Bach

. The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med 2002; 347: 911–920.

52.

Correale

Farez

. Association between parasite infection and immune responses in multiple sclerosis. Ann Neurol 2007; 61: 97–108.

53.

Ribeiro SB, Maia DF, Ribeiro JB, et al. Clinical and epidemiological profile of patients with multiple sclerosis in Uberaba, Minas Gerais, Brazil. Arq Neuropsiquiatr 2011; 69: 184–187.

54.

Lana-Peixoto MA, Frota ER, Campos GB, et al. Brazilian Committee for Treatment and Research in Multiple Sclerosis. The prevalence of multiple sclerosis in Belo Horizonte, Brazil. Arq Neuropsiquiatr 2012; 70: 102–107.