Several studies have evaluated patch testing for the diagnosis of drug eruptions, but widespread acceptance of this procedure is lacking in North America. The objective of this review is to address patch testing for the evaluation of exanthematous drug eruptions due to systemic antibiotics, using a MEDLINE database search for articles in English on patch testing for systemic drug eruptions caused by antibiotics
Get full access to this article
View all access options for this article.
References
1.
BigbyM, JickS, JickH, ArndtK. Drug-induced cutaneous reactions: a report from the Boston Collaborative Drug Surveillance Program on 152,438 consecutive inpatients, 1975 to 1982. JAMA, 1986; 256:3358-63.
2.
HunzikerT, KunziU, BraunschweigS, et al.Comprehensive hospital drug monitoring: adverse drug reactions: a 20-year survey. Allergy, 1997; 52:388-93.
3.
Van ArsdelPPJr. Allergy and adverse reactions. J Am Acad Dermatol, 1982; 6:833-45.
4.
BigbyM. Rates of cutaneous reactions to drugs. Arch Dermatol, 2001; 137:765-70.
5.
CalkinJM, MaibachHI. Delayed hypersensitivity drug reactions diagnosed by patch testing. Contact Dermatitis, 1993; 29:223-33.
6.
CoombsPRA, GellPGH. Classification of allergic reactions responsible for clinical hypersensitivity and disease. In: GellRRA, editor. Clinical aspects of immunology. Oxford (UK): Oxford University Press; 1968. p. 575-96.
BarbaudA, GonçaloM, BruynzeelD, BircherA. Guidelines for performing skin tests with drugs in the investigation of cutaneous adverse drug reactions. Contact Dermatitis, 2001; 45:321-8.
11.
RomanoA, Di FonsoM, PapaG, et al.Evaluation of adverse cutaneous reactions to aminopenicillins with emphasis on those manifested by maculopapular rashes. Allergy, 1995; 50:113-8.
12.
WilkinsonDS, FregertS, MagnussonB, et al.Terminology of contact dermatitis. Acta Derm Venereol, 1970; 50:287-92.
13.
BarbaudA. Drug patch testing in systemic cutaneous drug allergy. Toxicology, 2005; 209:209-16.
14.
LammintaustaK, Kortekangas-SavolainenO. The usefulness of skin tests to prove drug hypersensitivity. Br J Dermatol, 2005; 152: 968-74.
15.
BruynzeelDP, van KetelWG. Skin tests in the diagnosis of maculopapular drug eruptions. Semin Dermatol, 1987; 6:119-24.
16.
GonçaloM, FernandesB, OliveiraHS. Epicutaneous patch testing in drug eruptions. Contact Dermatitis, 2000; 42Suppl 2:22.
17.
BarbaudA, Reichert-PenetratS, TrechotP, et al.The use of skin testing in the investigation of cutaneous adverse drug reactions. Br J Dermatol, 1998; 139:49-58.
18.
GrandheNP, KaurI, ParsadD, DograS. Role of patch testing in antimicrobial drug eruptions. Contact Dermatitis, 2004; 50:259-61.
19.
OsawaJ, NaitoS, AiharaM, et al.Evaluation of skin test reactions in patients with non-immediate type drug eruptions. J Dermatol, 1990; 17:235-9.
20.
LisiP, LapomardaV, StingeniL, et al.Skin tests in the diagnosis of eruptions caused by betalactams. Contact Dermatitis, 1997; 37:151-4.
21.
RomanoA, ViolaM, MondinoC, et al.Diagnosing nonimmediate reactions to penicillins by in vivo tests. Int Arch Allergy Immunol, 2002; 129:169-74.
22.
BarbaudA, TrechotP, Weber-MullerF, et al.Drug skin tests in cutaneous adverse drug reaction to pristinamycin: 29 cases with a study of cross-reaction between synergistins. Contact Dermatitis, 2004; 50:22-6.
23.
MayenceC, DompmartinA, VerneuilL, et al.Value of patch tests in pristinamycin-induced drug eruptions. Contact Dermatitis, 1999; 40:161-2.
24.
LammintaustaK, TokolaR, KalimoK. Cutaneous adverse reactions to clindamycin: results of skin tests and oral exposure. Br J Dermatol, 2002; 146:643-8.
25.
PatriarcaG, D'AmbrosioC, SchiavinoD, et al.Clinical usefulness of patch and challenge tests in the diagnosis of cell-mediated allergy to betalactams. Ann Allergy Asthma Immunol, 1999; 83:257-66.
26.
BruynzeelDP, von Blomberg-van der FlierM, ScheperRJ, et al.Penicillin allergy and the relevance of epicutaneous tests. Dermatologica, 1985; 171:429-34.
27.
TorresMJ, Sánchez-SabatéE, ÁlvarezJ, et al.Skin test evaluation in nonimmediate allergic reactions to penicillins. Allergy, 2004; 59:219-24.
28.
Pérez PimientoA, Gómez MartínezM, Mínguez MenaA, et al.Aztreonam and ceftazidime: evidence of in vivo cross allergenicity. Allergy, 1998; 53:624-5.
29.
RietschelRL, FowlerJF. Practical aspects of patch testing. In: RietschelRL, FowlerJF, editors. Fisher's contact dermatitis. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2001. p. 17-8.
30.
BruynzeelDP, van KetelWG. Repeated patch testing in penicillin allergy. Br J Dermatol, 1981; 104:157-9.
31.
RomanoA, Di FonsoM, PietrantonioF, et al.Repeated patch testing in delayed hypersensitivity to beta-lactam antibiotics. Contact Dermatitis, 1993; 28:190.
32.
VaillantL, CamenenI, LoretteG. Patch testing with carbamazepine: reinduction of an exfoliative dermatitis. Arch Dermatol, 1989; 125: 299.
33.
SanchezTS, Sanchez-PerezJ, AraguesM, Garcia-DiazA. Flare-up reaction of pseudoephedrine baboon syndrome after positive patch test. Contact Dermatitis, 2000; 42:312-3.
34.
TombRR, LepoittevinJP, EspinassouzeF, et al.Systemic contact dermatitis from pseudoephedrine. Contact Dermatitis, 1991; 24:86-8.
35.
MachetL, VaillantL, DardaineV, LoretteG. Patch testing with clobazam: relapse of generalized drug eruption. Contact Dermatitis, 1992; 26:347-8.
36.
Gonzaol-GarijoMA, de ArilaD, Rodriguez-NevadoI. Generalized reaction after patch testing with metamizol. Contact Dermatitis, 2001; 45:180.
37.
MashiahJ, BrennerS. A systemic reaction to patch testing for the evaluation of acute generalized exanthematous pustulosis. Arch Dermatol, 2003; 139:1181-3.
38.
WüthrichB, FabroL, WältiM. “Soforttyp”-Reacktionen auf Pyrazol-Derivate: Ergebnisse von Hauttesten und Antikörperbestimmungen. Dermatologica, 1986; 173:24-8.
39.
JonkerMJ, BruynzeelD. Anaphylactic reaction elicited by patch testing with diclofenac. Contact Dermatitis, 2003; 49:114-5.
40.
MaucherOM. Anaphylaktische reaktionen beim Epicutantest. Hautarzt, 1972; 23:139.
41.
EriksenHC. Anaphylactic shock caused by neomycin treated with external cardiac message. Ugeskr Laeger, 1963; 125:1077.
42.
KozakovaM. Subsokovy stav vyvolany epikutannym testom na chloramfenikol. Cesk Dermatol, 1976; 51:82-4.
43.
HausteinUF. Anaphylactic shock and contact urticaria after the patch test with professional allergens. Allerg Immunol, 1976; 22:349.
44.
PietzckerF, KunerV. Anaphylaxie nach epicutanem Ampicillin-Test. Z Hautkr, 1975; 50:437-40.
45.
BrownJL. Incomplete labeling of pharmaceuticals: a list of “inactive” ingredients. N Engl J Med, 1983; 309:439-41.
46.
De GrootAC. Clinical relevance of positive patch test reactions to preservatives and fragrances. Contact Dermatitis, 1999; 41:224-7.
47.
BruynzeelDP, van KetelWG. Patch testing in drug eruptions. Semin Dermatol, 1989; 8:196-203.
48.
BarbaudA, TrechotP, Reichert-PenetratS, et al.Relevance of skin tests with drugs in investigating cutaneous adverse drug reactions. Contact Dermatitis, 2001; 45:265-8.
49.
WarrenE, GeorgeS, YouJ, KazanjianP. Advances in the treatment of Pneumocystis carinii pneumonia. Pharmacotherapy, 1997; 17:900-16.
50.
BarbaudA, BeneMC, FaureG, SchmutzJL. Tests cutanés dans l'exploration des taxidermies supposées de mécanisme immunoallergique. Bull Acad Natl Med, 2000; 184:47-63.
51.
EgawaY. Use of patch-scratch tests to determine penicillin and cephem allergies. Nippon Ika Daigaku Zasshi, 1994; 61:389-404.
52.
IsogaiZ, SunoharaA, TsujiT. Pustular drug eruption due to bacampicillin hydrochloride in a patient with psoriasis. J Dermatol, 1998; 25:612-5.
53.
De GrootAC, editor. Patch testing: test concentrations and vehicles for 3700 chemicals. 2nd ed. Amsterdam: Elsevier Science;. 1994.
54.
StraussRM, GreenST, GawkrodgerDJ. Rifampicin allergy confirmed by an intradermal test, but with a negative patch test. Contact Dermatitis, 2001; 45:108.
55.
RebolloS, SanchezP, VegaJM, et al.Hypersensitivity syndrome from isoniazid with positive patch test. Contact Dermatitis, 2001; 45: 306.
56.
Galindo BonillaPA, Garcia RodriguezR, Feo BritoF, et al.Patch testing for allergy to beta-lactam antibiotics. Contact Dermatitis, 1994; 31:319-20.
57.
KamphofWG, RustemeyerT, BruynzeelDP. Sensitization to clavulanic acid in Augmentin. Contact Dermatitis, 2002; 47:47.
VeinNK.Occupational dermatoses in farmers. In: MaibachHI, editor. Occupational and industrial dermatology. Chicago: Year Book Medical; 1987. p. 436-46.
60.
LeeAY, YooSH. Chloramphenicol induced acute generalized exanthematous pustulosis proved by patch test and systemic provocation. Acta Derm Venereol, 1999; 79:412-3.
61.
BernedoN, GonzalezI, GastaminzaG, et al.Positive patch test in vancomycin allergy. Contact Dermatitis, 2001; 45:43.
