Colorimetric Study of Absorption and Excretion of 4-(p-Dimethylaminostyryl) Quinoline Methiodide and Related Compounds. ∗

Summary

1. A substantial portion, usually less than half, of the 4M2M, 4M2MCL 2E2E, and 2M2PM administered to rats and mice in the diet, was found by colorimetric measurements, in the feces. 2. Only a trace of dye color was detected in urine of rats that had received 4M2M or 4M2MC1 orally or subcutaneously. 3. Heating, or prolonged exposure to air, of samples of urine from animals that received 4M2M, 4M2MC1 or 2E2E orally, not subcutaneously, produced a pink color. The trace of material responsible for this color seemed to be formed from the dye in the digestive tract. 4. Very little unchanged dye was found in the tissues of rats and mice that had received 4M2M or 4M2MC1 orally. 5. A large part of the 4M2M or 4M2MC1 administered orally is evidently converted into other substances.