Journal of Medical Biography

Jacob Winslow (1669–1760), a celebrated anatomist in his day, made his name publishing numerous medical treatises and writing the four-volume Anatomical exposition of the structure of the human body. He gives his name to the foramen of Winslow, and is credited with numerous significant findings in neuroanatomy and biomechanics. His life is characterised by meticulous devotion to his discipline and divided by a torturous religious conversion. In addition to his contributions to anatomy, he is famously remembered for his treatise on the uncertainty of the signs of death, which has influenced practices surrounding death down to the present day.

Kenneth Mellanby was a distinguished biologist specialising in entomology. He helped to establish the first university in Nigeria and undertook pioneering work on the use of insecticides in agriculture. However, he will best be remembered for a series of experiments which he undertook on human volunteers during the Second World War. These experiments established the mechanism of transmission of scabies and allowed its effective control at a time when the condition had reached epidemic proportions, causing a significant adverse effect on public morale and military effectiveness. Mellanby’s wartime monograph on scabies remains to this day the definitive work on the disease and is still studied by dermatologists. His subsequent book Human Guinea Pigs is a remarkable account of the privations to which wartime volunteers willingly submitted themselves in a way that would have never passed any current medical ethics committee.

John Hatton, LSA MRCS FRCS MD (1817–1871), was apprenticed from 1833 to Joseph Jordan, MRCS FRCS (1787–1873), a well-known Manchester surgeon. Jordan, who had been teaching anatomy since 1814, closed his Mount Street Medical School in 1834 and was elected as surgeon to the Manchester Royal Infirmary in 1835. He continued to lecture on surgery and surgical pathology at the Infirmary, and sometimes at the Pine Street Medical School run by Thomas Turner, LSA FRCS (1793–1873). During 1837–38 Hatton transcribed and illustrated these lectures in a bound manuscript and also added notes and drawings in his personal copy of The Dublin Dissector. He gained his Licentiate of the Society of Apothecaries (LSA) in 1836 and Membership of the Royal College of Surgeons (MRCS) in 1839 and set up in Manchester as surgeon from around 1840. This paper is based on three previously unrelated documents in the University of Manchester Archives: a handwritten catalogue of specimens in Jordan’s Anatomy Museum, Hatton’s annotated copy of The Dublin Dissector and his manuscript record of Jordan’s lectures. These documents provide a valuable insight into medical education during the 1830s.

Carl Cori and Gerty Cori elucidated basic biochemical mechanisms involved in the utilization of energy by muscle and liver, first at Roswell Park Cancer Institute and then at Washington University. In 1929, they formulated the Cori cycle, the process by which glycogen is converted to glucose in liver and is then reconverted to glycogen in muscle. They later found that glycogen breakdown yielded glucose-1-phosphate (Cori ester) and lactate, key intermediates in the cycle; they also established that lactic acid provided the energy employed in muscle contraction. They later discovered phosphorylase, the enzyme that catalyzed glycogen breakdown. After purifiying and crystallizing muscle phosphorylase, they identified two forms of the enzyme and defined their respective roles in metabolic regulation. These studies emboldened other scientists to advance our knowledge of fundamental regulatory processes such as the adenylate cyclase-cyclic AMP system and enzyme phosphorylation. The Coris also built a world-renowned Department of Biochemistry at Washington University, which included seven future Nobelists. In 1947, the Coris were awarded the Nobel Prize, with Gerty Cori being the first American woman to win this prestigious honor.

The Bristol School of Artists developed between 1800 and 1840 and was a collaboration between professional and amateur artists, one of whom was Dr John King. King started his professional life in Bristol as assistant to Thomas Beddoes where one of his colleagues was Humphry Davy and the three of them worked in the Pneumatic Institute, attempting to cure tuberculosis with gases. King subsequently became a popular general practitioner in Clifton and his correspondence with patrons of art, romantic poets and his friends gives much information about the social life in Bristol in the early part of the 19th century.

Dr Joseph Dudley ‘Benjy’ Benjafield qualified from University College Hospital Medical School, London in 1912. He joined the Royal Army Medical Corps during World War I and was in charge of the 37th Mobile Bacteriological Laboratory serving with the British Egyptian Expeditionary Force when the Spanish flu struck in late 1918. He observed the features and clinical course of the pandemic and published his findings in the British Medical Journal in 1919. On return to civilian life, he was appointed as Consultant physician to St George’s Hospital, Hyde Park Corner, London where he remained in practice for the rest of his career. He was a respected amateur gentleman racing driver frequently racing at the Brooklands circuit from 1924 after buying a Bentley 3-litre and entering the Le Mans 24 h race seven times between 1925 and 1935, winning in 1927. He was one of an elite club of young men known as The Bentley Boys and went on to become a founding member of the British Racing Drivers Club (BRDC) in 1927. He rejoined the Royal Army Medical Corps during World War II, serving briefly again in Egypt. He died in 1957.

Reinhard Hoeepli was a Swiss-German physician with a distinguished career as a researcher and historian of medical parasitology. He spent the majority of his career at the Peking Union Medical College in Beijing, China, where he undertook research on host responses to parasitic infections, in particular describing the ‘Splendore-Hoeppli phenomenon’, between 1929 and 1952. During the Second World War, he acted as the Swiss honorary Consul in Japanese-occupied Beijing. After leaving China following the militarization of the College in the wake of the Korean War, he subsequently worked in Singapore and Liberia before retiring to Switzerland. Hoeppli is most widely known for his association with Sir Edmund Backhouse, a controversial and enigmatic Chinese scholar, who was his war-time patient towards the end of his life. With Hoeppli's encouragement, Backhouse wrote two scandalous and unpublishable memoirs which remained in Hoeppli's safe-keeping until his own death in 1973. However, the revelations by the historian Hugh Trevor-Roper in 1976 that Backhouse was a fraudster and fantasist has had a detrimental effect on Hoeppli's posthumous reputation that has overshadowed his many lifetime achievements. Alongside a biography of his life, an examination of the controversies of the Backhouse revelations on Hoeppli's repute is presented.

A founder of paleopathology, the study of disease in ancient human remains, Sir Marc Armand Ruffer, MD (1859–1917) served in Egypt, from 1896 to 1917, as a public-health administrator, epidemiologist, and pathologist. He was professor of Bacteriology at the Cairo Medical School, President of the Sanitary, Maritime, and Quarantine Council, member of the Indian Plague Commission, and author or co-author of 40 papers in palaeopathology. However, little is known of his early professional life, which encompassed his education, medical training, and research in England and France. The pre-Egyptian period, 1878 to 1896, was a time of extraordinary activity. Acquiring four academic Degrees at Oxford University and clinical experience at the University College Hospital, London (1878–1889), he was the clinical assistant of Louis Pasteur during the anti-rabies campaign (autumn 1889), interim President of the British Institute of Preventive Medicine (1893–1896), and immunology researcher (1890–1895), in London and Paris, under the guidance of Élie Metchnikoff (1845–1916). Ruffer developed the diphtheria antitoxin in Britain. In addition to a dissertation on hydrocephalus, he composed or co-authored 34 papers. A prolific writer, linguist, clinician, and administrator, he explored several medical sub-disciplines before concentrating on palaeopathology.

Announced in 1855, the Désormeaux endoscope articulated a scope expansion in medical utility of the uréthroscope initially presented to the Académie de médecine in late 1853. The former epochal term was never formally claimed, and although evidencing creative thinking by Désormeaux himself, production was a poorly acknowledged but seemingly close collaboration with two leading Parisian instrument makers: Maison Chevalier for the optical parts and Maison Charrière for the accessory catheter.